Dose and Time-Dependent Effects of Cyclooxygenase-2 Inhibition on Fracture-Healing

by Ann Marie Simon, and J. Patrick O'Connor

J Bone Joint Surg AmVolume 89(3):500-511

March 1, 2007

©2007 by The Journal of Bone and Joint Surgery, Inc.

Histograms illustrating the effects of celecoxib dose on fracture-healing.

Ann Marie Simon, and J. Patrick O'Connor J Bone Joint Surg Am 2007;89:500-511

©2007 by The Journal of Bone and Joint Surgery, Inc.

Histograms illustrating the effects of celecoxib treatment duration on fracture-healing.

Ann Marie Simon, and J. Patrick O'Connor J Bone Joint Surg Am 2007;89:500-511

©2007 by The Journal of Bone and Joint Surgery, Inc.

Histograms illustrating the effects of delayed celecoxib treatment on fracture-healing.

Ann Marie Simon, and J. Patrick O'Connor J Bone Joint Surg Am 2007;89:500-511

©2007 by The Journal of Bone and Joint Surgery, Inc.

Histograms illustrating that nonsteroidal anti-inflammatory drug treatment reduces fracture callus prostaglandin levels.

Ann Marie Simon, and J. Patrick O'Connor J Bone Joint Surg Am 2007;89:500-511

©2007 by The Journal of Bone and Joint Surgery, Inc.