Do Now

WRITE the QUESTIONS and ANSWER!!!

1. GALLERY WALK

GALLERY WALK

PROTEIN SYTHESIS ANALOGY: A NECKLACE FACTORY

The RIBOSOME is like…

A necklace factory.

Because… The whole purpose of the factory is to make necklaces (proteins)

The DNA is like…

The Boss

Because… it tells the factory workers which type of necklaces to make.

The mRNA is like…

The Secretary

Because… it delivers the necklace recipes and orders to the factory

The Boss (DNA) tells the secretary (mRNA) which necklaces (proteins) need to be made

The secretary (mRNA) delivers the Boss’s (DNA) necklaces order to the factory (Ribosome)

The tRNA is like…

The Delivery trucks

Because… it drops off the ingredients to the factory for the correct necklaces to be made

The trucks (tRNA) drop off the ingredients – the beads (amino acids) - to make the necklaces (proteins) that the Boss (DNA) ordered

So…

The Boss (DNA) gives the necklace orders and recipes to the Secretary (mRNA) to bring to the necklace factory (ribosomes).

The Delivery Trucks (tRNA) bring the ingredients (amino acids) to the necklace factory (ribosome), where the necklaces (proteins) are made and then shipped out

With your partner..

Take 1 minutes to discuss the analogy and how the necklace factory relates to protein synthesis

But…

What does this actually look like?

http://www.youtube.com/watch?v=NJxobgkPEAo

http://www.youtube.com/watch?v=B6O6uRb1D38

Annotate your drawing along with me…

Check Point

1) The diagram above depicts the process of ______________________________ synthesis, or how the cell makes proteins from DNA.

2) What is the name of the process happening inside the nucleus?

3) In one sentence, explain what happens in the nucleus.

4) To what organelle does mRNA go to after the first step of protein synthesis?

5) What step of protein synthesis happens here?

6) Explain what happens during the process you identified above.

PS Overview Practice

Using your knowledge of Protein Synthesis and the Necklace Analogy, Independently complete Protein Synthesis Review practice

Now…

We know that the mRNA brings the recipe to make the proteins

And, the tRNA brings the right ingredients (amino acids) to make the proteins

And, the Ribosome actually puts the ingredients together to make the proteins

BUT… How does the tRNA know which amino acids to bring…?

How does tRNA know which amino acid to bring?

1. Breaks mRNA into groups of 3 called CODON.

 2. Use a Codon Chart to TRANSLATE mRNA

CODON into AMINO ACID. 3. Amino acids linked together by the

RIBOSOME to form a polypeptide (PROTEIN) chain.

LET’S TRY IT…

DNA mRNA = TRANSCRIPTION

mRNA amino acids = TRANSLATION

So…

DNA RNA Protein

GUIDED PRACTICETranslation

TRANSCRIPTION RACE

DNA Complementary StrandmRNAAmino Acids

TRANSCRIPTION RACE

DNA CTA Complementary StrandmRNAAmino Acids

TRANSCRIPTION RACE

DNA GCAComplementary StrandmRNAAmino Acids

TRANSCRIPTION RACE

DNA GGTComplementary StrandmRNAAmino Acids

TRANSCRIPTION RACE

DNA TTC CACComplementary StrandmRNAAmino Acids

TRANSCRIPTION RACE

DNA GTA CATComplementary StrandmRNAAmino Acids

TRANSCRIPTION RACE

DNA CCT GTA TCAComplementary StrandmRNAAmino Acids

PRACTICE Protein synthesis

TAT

Protein Synthesis in Action

Pre-lab

ROLES: DNA: Reads the codes 1-10 to the mRNA. Can’t let mRNA see the code! mRNA: Needs a pencil and 10 long strips of paper, numbered 1-10. DNA

is transcribed…A=U, T=A, G=C, and C=G. Keep codes in groups of three letters.

Ribosome: Needs a pencil and the codon word chart. Using the mRNA codons, find the corresponding words, and write a sentence. Each sentence should begin with START and finish with STOP.

You will switch roles every 3 sentences (in this order…) DNA mRNA mRNA Ribosome Ribosome DNA

What does this look like in action..?

Autoville Practice

Using your knowledge of Protein Synthesis and the Cookie Analogy, Independently complete Autoville practice