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DNAk = HSP70. Anfinsen Cage. 1-2) SRP binds leader peptide (pausing translation), which will take it to the proper location 3) Once in place SRP falls off and the ribosome continues to translate protein 4) A peptidase cleaves the leader peptide and then BIP - PowerPoint PPT Presentation

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DNAk = HSP70

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Anfinsen Cage

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“Leader peptide”

1-2) SRP binds leader peptide (pausing translation), which will take it to the proper location

3) Once in place SRP falls off and the ribosome continues to translate protein

4) A peptidase cleaves the leader peptide and then BIP (an HSP70 like protein) binds to facilitate proper folding.

5) Dissociation of complex

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Nobel Prize2004

Cancer treatmentTargeting the proteasome

Ubiquitin tagging

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