dna: structure and function -...
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![Page 1: DNA: Structure and Function - cbsflab.comcbsflab.com/wp-content/uploads/2017/03/RNAestrutura-cbsf.pdf · Estrutura do DNA e RNA •Purinas –Adenina e Guanina •Pirimidinas –Citosina,](https://reader034.vdocuments.mx/reader034/viewer/2022051510/5c20f65409d3f2ef478c2e77/html5/thumbnails/1.jpg)
RNA: Estrutura
Prof. Dr. Marcelo Ricardo Vicari
![Page 2: DNA: Structure and Function - cbsflab.comcbsflab.com/wp-content/uploads/2017/03/RNAestrutura-cbsf.pdf · Estrutura do DNA e RNA •Purinas –Adenina e Guanina •Pirimidinas –Citosina,](https://reader034.vdocuments.mx/reader034/viewer/2022051510/5c20f65409d3f2ef478c2e77/html5/thumbnails/2.jpg)
RNA
• Ribose
• Timina é trocada pela Uracila
• Hélice de fita simples
Prof. Dr. Marcelo Ricardo Vicari
![Page 3: DNA: Structure and Function - cbsflab.comcbsflab.com/wp-content/uploads/2017/03/RNAestrutura-cbsf.pdf · Estrutura do DNA e RNA •Purinas –Adenina e Guanina •Pirimidinas –Citosina,](https://reader034.vdocuments.mx/reader034/viewer/2022051510/5c20f65409d3f2ef478c2e77/html5/thumbnails/3.jpg)
Estrutura do DNA e RNA
• Purinas – Adenina e Guanina
• Pirimidinas – Citosina, Timina, Uracil
Desoxiadenosina
5´monofostato
Desoxiguanosina
5´monofostato
Desoxicitidina
5´monofostato
Desoxitimidina
5´monofostatoDesoxiuracila
5´monofostato
Prof. Dr. Marcelo Ricardo Vicari
![Page 4: DNA: Structure and Function - cbsflab.comcbsflab.com/wp-content/uploads/2017/03/RNAestrutura-cbsf.pdf · Estrutura do DNA e RNA •Purinas –Adenina e Guanina •Pirimidinas –Citosina,](https://reader034.vdocuments.mx/reader034/viewer/2022051510/5c20f65409d3f2ef478c2e77/html5/thumbnails/4.jpg)
Estrutura química do DNA
E RNARNA DNA
Prof. Dr. Marcelo Ricardo Vicari
![Page 5: DNA: Structure and Function - cbsflab.comcbsflab.com/wp-content/uploads/2017/03/RNAestrutura-cbsf.pdf · Estrutura do DNA e RNA •Purinas –Adenina e Guanina •Pirimidinas –Citosina,](https://reader034.vdocuments.mx/reader034/viewer/2022051510/5c20f65409d3f2ef478c2e77/html5/thumbnails/5.jpg)
Prof. Dr. Marcelo Ricardo Vicari
![Page 6: DNA: Structure and Function - cbsflab.comcbsflab.com/wp-content/uploads/2017/03/RNAestrutura-cbsf.pdf · Estrutura do DNA e RNA •Purinas –Adenina e Guanina •Pirimidinas –Citosina,](https://reader034.vdocuments.mx/reader034/viewer/2022051510/5c20f65409d3f2ef478c2e77/html5/thumbnails/6.jpg)
RNA - tipos
Prof. Dr. Marcelo Ricardo Vicari
![Page 7: DNA: Structure and Function - cbsflab.comcbsflab.com/wp-content/uploads/2017/03/RNAestrutura-cbsf.pdf · Estrutura do DNA e RNA •Purinas –Adenina e Guanina •Pirimidinas –Citosina,](https://reader034.vdocuments.mx/reader034/viewer/2022051510/5c20f65409d3f2ef478c2e77/html5/thumbnails/7.jpg)
Tipos de RNA e Funções:
a- RNA mensageiro (mRNA)
• Transporte da informação genética do núcleo para o citoplasma onde ocorrerá a síntese
proteica
b- RNA ribossômico (rRNA)
* Transcrito a partir do DNA, na região organizadora do nucléolo. Associa-se com proteínas
ribossômicas do núcleo e migra para o citoplasma para formar o RIBOSSOMO
c- RNA transportador (tRNA)
• Moléculas pequenas de RNA c/ 73 – 93 nucleotídeos
• transporte de aminoácidos p/ síntese proteica
• pelo menos 1 t-RNA para cada um dos 20 aminoácidos
• estrutura diferente dos demais tipos de RNA
• fita do t-RNA apresenta regiões de complementariedade, fita enrola-se dando o formato de
folha de trevo modificado
•Folíolo Central (anticódon) Reconhece Códon
Prof. Dr. Marcelo Ricardo Vicari
![Page 8: DNA: Structure and Function - cbsflab.comcbsflab.com/wp-content/uploads/2017/03/RNAestrutura-cbsf.pdf · Estrutura do DNA e RNA •Purinas –Adenina e Guanina •Pirimidinas –Citosina,](https://reader034.vdocuments.mx/reader034/viewer/2022051510/5c20f65409d3f2ef478c2e77/html5/thumbnails/8.jpg)
Prof. Dr. Marcelo Ricardo Vicari
![Page 9: DNA: Structure and Function - cbsflab.comcbsflab.com/wp-content/uploads/2017/03/RNAestrutura-cbsf.pdf · Estrutura do DNA e RNA •Purinas –Adenina e Guanina •Pirimidinas –Citosina,](https://reader034.vdocuments.mx/reader034/viewer/2022051510/5c20f65409d3f2ef478c2e77/html5/thumbnails/9.jpg)
tRNA
-Estrutura secundária com grampos e alças formando um trevo
-Alto número de bases modificadas
depois da sua transcrição
Prof. Dr. Marcelo Ricardo Vicari
![Page 10: DNA: Structure and Function - cbsflab.comcbsflab.com/wp-content/uploads/2017/03/RNAestrutura-cbsf.pdf · Estrutura do DNA e RNA •Purinas –Adenina e Guanina •Pirimidinas –Citosina,](https://reader034.vdocuments.mx/reader034/viewer/2022051510/5c20f65409d3f2ef478c2e77/html5/thumbnails/10.jpg)
Ribossomo Eucariótico
80S (4,6 x 106)
rRNAs:
Prof. Dr. Marcelo Ricardo Vicari
![Page 11: DNA: Structure and Function - cbsflab.comcbsflab.com/wp-content/uploads/2017/03/RNAestrutura-cbsf.pdf · Estrutura do DNA e RNA •Purinas –Adenina e Guanina •Pirimidinas –Citosina,](https://reader034.vdocuments.mx/reader034/viewer/2022051510/5c20f65409d3f2ef478c2e77/html5/thumbnails/11.jpg)
Prof. Dr. Marcelo Ricardo Vicari
![Page 12: DNA: Structure and Function - cbsflab.comcbsflab.com/wp-content/uploads/2017/03/RNAestrutura-cbsf.pdf · Estrutura do DNA e RNA •Purinas –Adenina e Guanina •Pirimidinas –Citosina,](https://reader034.vdocuments.mx/reader034/viewer/2022051510/5c20f65409d3f2ef478c2e77/html5/thumbnails/12.jpg)
outros tipos de RNAs
• RNA telomerase
• Interferência - RNAi
• Pequenos RNAs - snRNA
• RNA anti-senso
• RNA heterogêneo
• Interferência pequeno – siRNA
• Micro-RNA
Prof. Dr. Marcelo Ricardo Vicari
![Page 13: DNA: Structure and Function - cbsflab.comcbsflab.com/wp-content/uploads/2017/03/RNAestrutura-cbsf.pdf · Estrutura do DNA e RNA •Purinas –Adenina e Guanina •Pirimidinas –Citosina,](https://reader034.vdocuments.mx/reader034/viewer/2022051510/5c20f65409d3f2ef478c2e77/html5/thumbnails/13.jpg)
RNA de Interferência - RNAi
• Pequenas moléculas – 21 nucleotídeos
• Controle da expressão gênica
• Repressão tradução
• Degradação RNAm
• Alteram a estrutura da cromatina
• Inativam vírus e transposons
Prof. Dr. Marcelo Ricardo Vicari
![Page 14: DNA: Structure and Function - cbsflab.comcbsflab.com/wp-content/uploads/2017/03/RNAestrutura-cbsf.pdf · Estrutura do DNA e RNA •Purinas –Adenina e Guanina •Pirimidinas –Citosina,](https://reader034.vdocuments.mx/reader034/viewer/2022051510/5c20f65409d3f2ef478c2e77/html5/thumbnails/14.jpg)
RNA de Interferência pequenos -
siRNA
• Pequenas moléculas – 21-23 nucleoídeos
• Associam-se a complexos enzimáticos, formam o RNAi específicos
• Controle da expressão gênica
• Repressão tradução
• Degradação RNAm
Prof. Dr. Marcelo Ricardo Vicari
![Page 15: DNA: Structure and Function - cbsflab.comcbsflab.com/wp-content/uploads/2017/03/RNAestrutura-cbsf.pdf · Estrutura do DNA e RNA •Purinas –Adenina e Guanina •Pirimidinas –Citosina,](https://reader034.vdocuments.mx/reader034/viewer/2022051510/5c20f65409d3f2ef478c2e77/html5/thumbnails/15.jpg)
Micro RNA - miRNA
• Importantes na repressão da expressão gênica eucarioto
• 21 a 24 nucleotídeos
• Atuam negativamente para regular a expressão de um grande número de genes celulares
Prof. Dr. Marcelo Ricardo Vicari
![Page 16: DNA: Structure and Function - cbsflab.comcbsflab.com/wp-content/uploads/2017/03/RNAestrutura-cbsf.pdf · Estrutura do DNA e RNA •Purinas –Adenina e Guanina •Pirimidinas –Citosina,](https://reader034.vdocuments.mx/reader034/viewer/2022051510/5c20f65409d3f2ef478c2e77/html5/thumbnails/16.jpg)
RNA nuclear pequeno - snRNA
• 100 – 200 nucleotídeos
• Associam-se a proteínas - formam
pequenas ribonucleoproteínas nucleares
(snRNPs)
• Processamento mRNA
Prof. Dr. Marcelo Ricardo Vicari
![Page 17: DNA: Structure and Function - cbsflab.comcbsflab.com/wp-content/uploads/2017/03/RNAestrutura-cbsf.pdf · Estrutura do DNA e RNA •Purinas –Adenina e Guanina •Pirimidinas –Citosina,](https://reader034.vdocuments.mx/reader034/viewer/2022051510/5c20f65409d3f2ef478c2e77/html5/thumbnails/17.jpg)
Prof. Dr. Marcelo Ricardo Vicari
![Page 18: DNA: Structure and Function - cbsflab.comcbsflab.com/wp-content/uploads/2017/03/RNAestrutura-cbsf.pdf · Estrutura do DNA e RNA •Purinas –Adenina e Guanina •Pirimidinas –Citosina,](https://reader034.vdocuments.mx/reader034/viewer/2022051510/5c20f65409d3f2ef478c2e77/html5/thumbnails/18.jpg)
Prof. Dr. Marcelo Ricardo Vicari
![Page 19: DNA: Structure and Function - cbsflab.comcbsflab.com/wp-content/uploads/2017/03/RNAestrutura-cbsf.pdf · Estrutura do DNA e RNA •Purinas –Adenina e Guanina •Pirimidinas –Citosina,](https://reader034.vdocuments.mx/reader034/viewer/2022051510/5c20f65409d3f2ef478c2e77/html5/thumbnails/19.jpg)
Prof. Dr. Marcelo Ricardo Vicari
![Page 20: DNA: Structure and Function - cbsflab.comcbsflab.com/wp-content/uploads/2017/03/RNAestrutura-cbsf.pdf · Estrutura do DNA e RNA •Purinas –Adenina e Guanina •Pirimidinas –Citosina,](https://reader034.vdocuments.mx/reader034/viewer/2022051510/5c20f65409d3f2ef478c2e77/html5/thumbnails/20.jpg)
Prof. Dr. Marcelo Ricardo Vicari
![Page 21: DNA: Structure and Function - cbsflab.comcbsflab.com/wp-content/uploads/2017/03/RNAestrutura-cbsf.pdf · Estrutura do DNA e RNA •Purinas –Adenina e Guanina •Pirimidinas –Citosina,](https://reader034.vdocuments.mx/reader034/viewer/2022051510/5c20f65409d3f2ef478c2e77/html5/thumbnails/21.jpg)
Prof. Dr. Marcelo Ricardo Vicari
![Page 22: DNA: Structure and Function - cbsflab.comcbsflab.com/wp-content/uploads/2017/03/RNAestrutura-cbsf.pdf · Estrutura do DNA e RNA •Purinas –Adenina e Guanina •Pirimidinas –Citosina,](https://reader034.vdocuments.mx/reader034/viewer/2022051510/5c20f65409d3f2ef478c2e77/html5/thumbnails/22.jpg)
Prof. Dr. Marcelo Ricardo Vicari
![Page 23: DNA: Structure and Function - cbsflab.comcbsflab.com/wp-content/uploads/2017/03/RNAestrutura-cbsf.pdf · Estrutura do DNA e RNA •Purinas –Adenina e Guanina •Pirimidinas –Citosina,](https://reader034.vdocuments.mx/reader034/viewer/2022051510/5c20f65409d3f2ef478c2e77/html5/thumbnails/23.jpg)
Prof. Dr. Marcelo Ricardo Vicari
![Page 24: DNA: Structure and Function - cbsflab.comcbsflab.com/wp-content/uploads/2017/03/RNAestrutura-cbsf.pdf · Estrutura do DNA e RNA •Purinas –Adenina e Guanina •Pirimidinas –Citosina,](https://reader034.vdocuments.mx/reader034/viewer/2022051510/5c20f65409d3f2ef478c2e77/html5/thumbnails/24.jpg)
Prof. Dr. Marcelo Ricardo Vicari
![Page 25: DNA: Structure and Function - cbsflab.comcbsflab.com/wp-content/uploads/2017/03/RNAestrutura-cbsf.pdf · Estrutura do DNA e RNA •Purinas –Adenina e Guanina •Pirimidinas –Citosina,](https://reader034.vdocuments.mx/reader034/viewer/2022051510/5c20f65409d3f2ef478c2e77/html5/thumbnails/25.jpg)
Prof. Dr. Marcelo Ricardo Vicari