dna replication, repair, recombination
TRANSCRIPT
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Cell & Molecular
Biology
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DNA Replication,Repair andRecombination
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Chapter 6
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DNA Replication
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Three models of DNA replication
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Figure 6-6 Essential Cell Biology (© Garland Science 2010)
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Each strand of DNAin a double helixserves as a template
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Base Pairingis at the heartof DNA replication
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Figure 6-4 Essential Cell Biology (© Garland Science 2010)
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Replication Origins
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“...positions at which the DNAis first opened up... usually marked by a particular sequence of nucleotides.”
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Figure 6-5 Essential Cell Biology (© Garland Science 2010)
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Replication Forks
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Figure 6-9 Essential Cell Biology (© Garland Science 2010)
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DNA replicationis bidirectional
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DNA is synthesized5’ to 3’
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Figure 6-10 Essential Cell Biology (© Garland Science 2010)
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Figure 6-11 Essential Cell Biology (© Garland Science 2010)
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Leading and lagging strands
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Figure 6-12 Essential Cell Biology (© Garland Science 2010)
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DNA Polymerase
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Accuracy
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Nucleotide addition is catalyzed only when base-pairing is correct.
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Figure 6-13 Essential Cell Biology (© Garland Science 2010)
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Proofreading clips out added nucleotides thatdo not correctly base-pair.
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Figure 6-14 Essential Cell Biology (© Garland Science 2010)
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For proofreading to work,DNA must be synthesizedfrom 5’ to 3’.
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Figure 6-15 Essential Cell Biology (© Garland Science 2010)
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DNA polymerase can only add nucleotides to a base-paired nucleotidein a DNA double helix.
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So the synthesis of DNAbegins with RNA primers.
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Figure 6-17a Essential Cell Biology (© Garland Science 2010)
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Figure 6-16 Essential Cell Biology (© Garland Science 2010)
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Figure 6-17a Essential Cell Biology (© Garland Science 2010)
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Figure 6-17b Essential Cell Biology (© Garland Science 2010)
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The Replication Machine
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Helicase
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Single-Strand Binding Protein
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Sliding Clamp
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Clamp Loader
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DNA Primase
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Telomerase
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Figure 6-17b Essential Cell Biology (© Garland Science 2010)
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Figure 6-18 Essential Cell Biology (© Garland Science 2010)
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DNA Repair
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Replication Errors
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Figure 6-21a Essential Cell Biology (© Garland Science 2010)
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Figure 6-21b Essential Cell Biology (© Garland Science 2010)
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Figure 6-21c Essential Cell Biology (© Garland Science 2010)
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Mismatch Repair
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Figure 6-22 Essential Cell Biology (© Garland Science 2010)
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DNA Damage
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Depurination
Deamination
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Figure 6-23 Essential Cell Biology (© Garland Science 2010)
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Figure 6-25a Essential Cell Biology (© Garland Science 2010)
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Figure 6-25b Essential Cell Biology (© Garland Science 2010)
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ThymineDimerization
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Figure 6-24 Essential Cell Biology (© Garland Science 2010)
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Repair: 1. excision2. resynthesis3. ligation
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Figure 6-26 Essential Cell Biology (© Garland Science 2010)
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Double-Stranded Breaks
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Nonhomologous End-Joining
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Figure 6-27 Essential Cell Biology (© Garland Science 2010)
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HomologousRecombination
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“...the exchange of genetic information between a pair of homologous DNA molecules...”
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Double-strandedbreak repair
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Figure 6-31 (part 1 of 2) Essential Cell Biology (© Garland Science 2010)
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Figure 6-31 (part 2 of 2) Essential Cell Biology (© Garland Science 2010)
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Meiosis
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Page 183
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Figure 6-30 Essential Cell Biology (© Garland Science 2010)
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Figure 6-31 (part 1 of 2) Essential Cell Biology (© Garland Science 2010)
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Figure 6-31 (part 2 of 2) Essential Cell Biology (© Garland Science 2010)
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Mobile GeneticElements
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or,Transposons
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DNA-Only Transposons
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Figure 6-32 Essential Cell Biology (© Garland Science 2010)
3 Bacterial Transposons
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Transposase
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Figure 6-33 Essential Cell Biology (© Garland Science 2010)
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Retrotransposons
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Figure 6-34 Essential Cell Biology (© Garland Science 2010)
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Reverse Transcriptase
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