diversity plus panel of biomap® systems
DESCRIPTION
This presentation describes the set of 12 BioMAP® systems that comprise the Diversity Plus panel. The BioMAP® systems platform is a drug discovery technology from BioSeek, LLC.TRANSCRIPT
Bridging the Gap From In Vitro to In Vivo
BioMAP® Diversity Plus Profiling
1
BioMAP® Diversity Plus Panel
12 Systems include a variety of immune and tissue cell types
• Primary human vascular cells (endothelial and smooth muscle), epithelial cells (skin
and lung), fibroblasts, myofibroblasts, T cell, B cell, monocytes, macrophages
• Good blend of co-culture and single cell type BioMAP® Systems
• Format: > 140 biomarker readouts; 4-dose, single well format
• Useful for:
• Mechanism of action studies
• Covers most mechanisms represented in BioMAP Database
• Safety-related compound properties
• Efficacy-related activities for autoimmune or inflammatory disease areas
• Business terms
• Single compound profiling with Terms and Conditions, per compound pricing
• Competitive terms for ongoing profiling agreements or large studies
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3
BioMAP® Diversity Plus Panel (1-6)
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BioMAP® Diversity Plus Panel (7-12)
BioMAP® Diversity Plus – Cell Types & Co-cultures
B cells
Endothelial Cells
Bronchial Epithelial Cells
Keratinocytes
Smooth Muscle Cells
Dermal Fibroblasts
Lung Fibroblasts
Peripheral Blood Mononuclear Cells
Macrophages
BioMAP Systems
5
10 primary human cell types
12 assay systems
• Different cell types, co-culture combinations
• Different activation conditions – disease models
BioMAP® Diversity Plus – Biology Covered
Vascular Biology
Wound Healing
Th1 Inflammation
Skin Biology
Th2 Responses
Immune Biology
Th17 Biology
Lung Biology
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BioMAP® Profiling – Process
7
Compounds
are ShippedCell Culture Data Analysis
Report
Delivery
BioMAPDatabase
Readout Assays
6-8 weeks (12 systems) 1-2 weeks
Automated, Validated
ProceduresSpecially trained staff
Proprietary Database
and Analysis Software
High Throughput Lab
Program Manager
Bridging the Gap From In Vitro to In Vivo
BioMAP® Diversity Plus ProfilingContact
Carmen Bryant
Program Manager
BioSeek, LLC
650-416-7647
BioSeek, LLC310 Utah, #100South San Francisco, CA 94080