disspresentation 0419
TRANSCRIPT
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THE ROLE OF THE HPC-PFC PATHWAY AND SCHEMA MECHANISMS IN
PSYCHIATRIC DISEASES
By Siobhan Campbell
Honours Neuroscience Dissertation- Library Project
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Introduction
The HPC-PFC Pathway:vHPC vmPFC
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The Stress Response - HPA
Walker et al. (2008)
MRs/GRsHPC/PFC
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Hypothesis
The HPC-PFC pathway is damaged by stress, disrupting neural function and cognition in psychiatric disease
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Outline
Schema
Pathway
Stress & Structure
Stress & Function
Cognition & Disease
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Cognition in Disease - Schemas
• Previous knowledge networks• Increase rate of consolidation• Facilitate decision-making• Built upon HPC-PFC interactions
Lewis et al. (2011)
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History of ResearchTract-Tracing
1977 – 1995 Electrophysiology
1996 – 2000 Lesions
2004 – 2011
The HPC-PFC
Pathway
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Lesions Disrupt Oscillations
vHPC lesions reduces oscillations in vmPFC
Brockmann et al. (2011)
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Brain Oscillations
Lewis et al. (2011)
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Stress Disrupts Oscillations
Oliveria et al. (2013)
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Stress Disrupts Structure
vHPC vPFC @ Layer2
• Stress affects pathway input
• PFC atrophy
Cerqueria et al. (2007)
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Stress Disrupts Function@HPC-PFC synapses
LTP memory traces
@CA1 synapses
Booth et al. (2014)
Cerqueria et al. (2007)
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Memory in Disease - Depression@HPC-PFC synapses:Stress impairs LTPAntidepressants restore LTP
Rocher et al. (2004)
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Memory in Disease - Schizophrenia
Suh et al. (2013)
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Memory in Disease - Schizophrenia
Sigurdsson et al. (2010)
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Pathway in Disease - Schema
ACC/PrL: • schema• decision-making• stress
Conclusion:Pathway damage could prevent activation of schemas
Tse et al. (2011)
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SummaryThe HPC-PFC pathway:1. Exists2. Interacts with stress and disease3. Is involved in creating and updating
schemas
Hypothesis:The HPC-PFC pathway is damaged by stress, disrupting neural function and cognition in psychiatric disease.
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Future StudiesSchema & Schizophrenia
Animals - Tse et al. (2007) Humans – Van Kesteren et al. (2010)
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Author: Siobhan CampbellSupervisor: Lisa Genzel
Morris LabCCNS
1 George Sq.Edinburgh