discovery mi€¦ · the lcd measured in 0.625 mm slices and tested for both head and body modes...

DISCOVERY™ MI

Discovery is a trademark of General Electric Company.

Meaningful insights. From your patient to every patient.

TRUE DISCOVERY DISCOVERY MI LIGHTBURST DIGITAL QUANTITATION DIGITAL INDUSTRIAL SHAPING THE FUTURECLINICAL IMAGES DISCLAIMERSREVOLUTION EVOSCALABILITY

2 5 Y E A R S O F I N N O V A T I O N

Discovery LS

Discovery STDiscovery STE

Discovery VCT

Discovery 690Discovery 600

Discovery 710

Discovery 610

SIGNA PET/MR

Discovery IQ

Discovery MI/DR

Advance


Continue your efforts to diagnose and stage disease earlier with technology that detects smaller lesions1

CLINICAL WORK THAT EXCELS BEYOND WHAT YOU THOUGHT WAS POSSIBLE

Expand your diagnostic service offerings

1Improved detectability as demonstrated in phantom testing


I N T R O D U C I N G D I S C O V E R Y M I

Q . C L E A R

• Up to 2x improvement in quantitative accuracy (SUVmean)

• Up to 2x improvement in image quality (SNR)

• Q.CorePower+ Dual reconstruction for advanced needs

D I G I T A L M O T I O N F R E E

• Q.Static – MotionFree for all patients

• Q.Freeze – 100% counts, 100% motion correction

• Q.Flow – Patient centric workflow

L I G H T B U R S T D I G I T A L D E T E C T O R

• Up to 2x improvement in volumetric resolution1

• Highest NEMA sensitivity of any TOF PET/CT system2

• Highest NECR of any TOF PET/CT system3

R E V O L U T I O N T M E V O

• HiLight Clarity Detector – 0.28 mm resolution

• Up to 82% reduction in CT dose with ASIR-VTM 4,5

• Smart MAR – One stop shop PET/CT

3 Comparing Discovery MI to other TOF PET/CT scanners reported in ITN online comparison charts (May 2016), Up to 20 kBq/ml

4 In clinical practice, the use of ASiR-V may reduce CT patient dose depending on the clinical task, patient size, anatomical location, and clinical practice. A consultation with a radiologist and a physicist should be made to

determine the appropriate dose to obtain diagnostic image quality for the particular clinical task. Low Contrast Detectability (LCD), Image Noise, Spatial Resolution and Artifact were assessed using reference factory protocols

comparing ASiR-V and FBP. The LCD measured in 0.625 mm slices and tested for both head and body modes using the MITA CT IQ Phantom (CCT183, The Phantom Laboratory), using model observer method.

5 Image quality as defined by low contrast detectability.


LightBurst Digital Detector

ENGINEERED FOR PRECISION


L I G H T B U R S T D I G I T A L

E N G I N E E R E D F O R P R E C I S I O N


Large to medium scintillator crystal array share a common light guide

Photomultiplier (QUAD-PMT) without electronics

LightBurst Digital DetectorConventional PET

L I G H T B U R S T D I G I T A L D E T E C T O R

E N G I N E E R E D F O R P R E C I S I O N

Silicon Photomultiplier (SiPM) with ASIC

Excellent timing and energy resolutions

Digital Compton scatter recovery with no resolution trade off

High thermal conductive pad

Extracts heat from detector improving stability

Small Scintillator crystal and Enhanced Spectral Reflectors

Excellent count-rate performance and system resolution


15

.6cm

20

.0 c

m

Conventional PET

Sensitivity

7.5 cps/kBq

30 kcps @ 2.3 kBq/ml (FDG)

Coverage

15.6 cm axial FOV

7-8 bed per whole-body

Technology

Analog TOF – 1024x PMT

549 ps TOF resolution

Crystal - LBS

4.2 x 6.3 x 25 mm3


Sensitivity

13.5 cps/kBq NEMA

46,6 cps/kBq Effective

53 kcps @ 2.4 kBq/mL (FDG)

Technology

Digital TOF – 9792x SiPM

385 ps TOF resolution

Coverage

20.0 cm axial FOV

5-6 bed per wholebody

Crystal – LBS

3.95 x 5.3 x 25 mm3

L I G H T B U R S T D I G I T A L D E T E C T O RE N G I N E E R E D F O R P R E C I S I O N


LightBurst Digital Detector Conventional PET

3.95 x 5.3 x 25 mm3

4.2 mm typical resolution

385 ps timing resolution

up

to

5c

m

16

mm

L o w e r R e s o l u t i o n H i g h e r R e s o l u t i o n

S M A L L E R B L O C K D E S I G NR E S O L U T I O N & S E N S I T I V I T Y


Conventional PET

S1 S2 S1 + S2

✗ ✗ ✓

L o w R e s o l u t i o n

H i g h S e n s i t i v i t y

• U P T O 7 5 % O F T H E 5 1 1 K E V P H O T O N C O M P T O N S C AT T E R W I T H I N T H E B L O C K D E T E C T O R

• L O S S O F S E N S I T I V I T Y O N T H E

D E T E C T O R E D G E

• L O S S O F R E S O L U T I O N

C O M P T O N R E C O V E R YR E S O L U T I O N & S E N S I T I V I T Y



S1 = E1 ; T1 ; X1Y1

E1: 211keV

S2 = E2 ; T2 ; X2Y2

E2: 300keV

E1 + E2 ; T1 ; X1Y1✗E1 + E2 = 511keV

H i g h e r R e s o l u t i o n

H i g h e r S e n s i t i v i t y

✗

✓

C o n v e n t i o n a l C o m p t o n R e c o v e r y

Conventional PET

S1 S2 S1 + S2

✗ ✗ ✓

L o w R e s o l u t i o n

H i g h S e n s i t i v i t y



Analog Compton recovery within

the block

Digital Compton recovery from adjacent block

Without Compton

scatter recovery

✓ 20% Sensitivity boost

✓ 20% Peak NECR recovery

✓ 385 ps TOF resolution

✓ ~9.6% energy resolution

L I G H T B U R S T D I G I T A L



18°C PET detector liquid cooling

Temp. sensor & gain control


Q . T E M PA C C U R A C Y & S T A B I L I T Y


A B R I L L I A N T I N T R O D U C T I O N T O A L L D I S C O V E R Y M I C A N D O

White is the primary copy color

Tertiary color

Light gray can be used as a secondary color on dark backgrounds

Dark gray can be used as a secondary color on lighter backgrounds

S i g n i f i c a n t l y b e t t e r s m a l l l e s i o n d e t e c t a b i l i t y 1

U p t o 2 x i m p r o v e m e n t i n v o l u m e t r i c r e s o l u t i o n 1

H i g h e s t N E M A s e n s i t i v i t y o f a n y T O F P E T / C T s y s t e m 2

H i g h e s t N E C R o f a n y T O F P E T / C T s y s t e m 3


2 X I M P R O V E M E N T I N V O L U M E T R I C R E S O L U T I O N 1

Anthropomorphic (Torso) Phantom with 5, 6 and 8 mm spheres in various regions

Reconstruction: VPFXS

D I S C O V E R Y M I

8mm Ø objects clearly visible5 mm Ø clearly visible

65 mm3 volumetric resolution

5 mm

8 mm

6 mm

5 mm


D I S C O V E R Y P E T / C T 7 1 0

8mm Ø objects clearly visible5 mm Ø not visible

268 mm3 volumetric resolution

5 mm

8 mm

6 mm

5 mm

Conventional PET


S M A L L L E S I O N

D E T E C T A B I L I T YConventional PETLightBurst Digital Detector

SUVmax: 4.5Lesion Size: 1cm

SUVmax: 2.1

DISCOVERY MI sensitivity and LightBurst Digital detector simultaneously provides excellent image quality and resolution. Discovery MI provides more confidence when looking for small metastatic disease in difficult areas such as the liver.

1 5 m i n u t e s

2 9 8 M B q / 8 m C i F D G

9 6 m i n u t e u p t a k e

A c q u i s i t i o n

P a t i e n t w i t h h i s t o r y o f

M e l a n o m a r e f e r r e d t o

P E T / C T f o r r e s t a g i n g

a n d m e t a s t a t i c

e v a l u a t i o n

P a t i e n t H i s t o r y

2 2 . 6

P a t i e n t B M I

Follow-up CT

Courtesy Stanford University, A. Iagaru, MD



D E T E C T A B I L I T Y

Courtesy University of Zurich

2 m i n u t e s / F O V

3 2 9 M B q / 8 . 9 m C i F D G




H e a d a n d N e c k C a n c e r

r e f e r r e d t o P E T f o r

e v a l u a t i o n o f l y m p h

n o d e i n v o l v e m e n t .


2 5 . 6

P a t i e n t B M I

OSEM 70CM DFOV Hi Res Q.Clear

SUVmax: 5.71 g/ml SUVmax: 10.16 g/ml


U L T R A F A S T A C Q U I S I T I O N



32

GE 2 min / bed14 min Scan

GE 30 sec / bed210 sec Scan

GE 15 sec / bed105 sec Scan

Discovery MI

Size & weight of patient 1.75 m / 80 kg

Injected activity 3.08 MBq/kg

# bed positions / scan length 7 / 1.12 m

A C C E L E R AT E R E S E A R C H

NEMA Sensitivity13.5 cps/kBqNEMA Peak NECR180 kcps @ 20 kBq/mL

NEMA Sensitivity7.5 cps/kBqNEMA Peak NECR130 kcps @ 30 kBq/ml

▪ I N C R E A S E L O W - Y I E L D T R A C E R

C A P A B I L I T Y W I T H O U T

I M P A C T I N G I M A G E Q U A L I T Y

A N D S M A L L L E S I O N

D E T E C TA B I L I T Y 1

▪ P U R S U E G R O U N D B R E A K I N G

R E S E A R C H W I T H F A S T E R

D E C A Y I N G T R A C E R S


R E V O L U T I O N E V O

Dual Energy

Performix 40 Plus tube

HighlightClarity detector

P e r f o r m i x 4 0 P l u s t u b e

A S i R - V

D u a l E n e r g y

S m a r t M A R

H i L i g h t C l a r i t y D e t e c t o r

D e s i g n e d f o r t h e m o s t d e m a n d i n g e x a m s – 0 . 3 5 s i n r o u t i n e

U p t o 8 2 % r e d u c t i o n i n C T d o s e a t s a m e i m a g e q u a l i t y 4 , 5

T i s s u e c h a r a c t e r i z a t i o n u s i n g C T D u a l E n e r g y t e c h n i q u e w i t h A W

M e t a l A r t i f a c t R e d u c t i o n f o r e v e r y P E T / C T e x a m

4 4 % l o w e r e l e c t r o n i c n o i s e t h a n p r e v i o u s g e n e r a t i o n


0 . 3 5 s e cI N R O U T I N E E X A M S

Gated acquisition

• 0.35 sec/rot

• Cardiac pitch

• 63-68 BPM

Helical acquisition:• 0.35 sec/rot• 1.531 pitch• 2.5 sec scan

Total acquisition• 4.43 mGy CTDIvol• 942 mGy-cm DLP• Iodine: 80 cc @ 4.0 cc/s • Saline: 40 cc @ 3.0 cc/s

Gated

Non-gated

TAVI planning in 14 sec with single contrast injection


Ultra-low-dose chest (0.08 mSv) reconstruction with filtered back-projection

Same study reconstructed using ASiR-V

Up to 82% reduced dose 4,5

In routine imaging, ASiR-V has been shown to reduce dose by up to 82% compared to standard FBP reconstruction at the same image quality.

82%Lower dose

Obtained using a chest factor of 0.014*DLP

A S I R - VI N R O U T I N E E X A M S


Acquisition09/09/14

100 kV

BMI 24

Helical

Standard kernel

ASiR-V 40%

5.0 mGy-cm DLP

Acquisition 09/02/14

120 kV

BMI 24

Helical

Standard kernel

ASiR 50%

12.2 mGy-cm DLP

ASiR-V – Revolution EVOASiR - Optima CT 660)

A S I R - VI N R O U T I N E E X A M S


Smart MARConventional CT

A V A I L A B L E F O R A L L E X A M S

• O N L Y O N E S C A N , R E A L T I M E R E C O N T R U C T I O N

• P R O J E C T I O N B A S E D T E C H N I Q U E F O R B E S T

A C C U R A C Y

• F U L L V E R S AT I L I T Y : H I P I M P L A N T S , D E N TA L F I L L I N G S , S C R E W S O R O T H E R M E TA L I N T H E B O D Y

S M A R T M A RM E T A L A R T I F A C T R E D U C T I O N



D E T E C T A B I L I T YConventional PETLightBurst Digital Detector

SUVmax: 4.5Lesion Size: 1cm

SUVmax: 2.1

DISCOVERY MI sensitivity and LightBurst Digital detector simultaneously provides excellent image quality and resolution. Discovery MI provides more confidence when looking for small metastatic disease in difficult areas such as the liver.

1 5 m i n u t e s

2 9 8 M B q / 8 m C i F D G







e v a l u a t i o n


2 2 . 6

P a t i e n t B M I

Follow-up CT




D E T E C T A B I L I T Y


1 5 m i n u t e s

2 9 8 M B q / 8 m C i F D G







e v a l u a t i o n


2 2 . 6

P a t i e n t B M I

OSEM 70CM DFOV Hi Res Q.Clear


C L I N I C A L E X C E L L E N C E

A N D E X P A N S I O N


Conventional CTSmart MAR

(metal Artefact Reduction)

Seamlessly apply SmartMAR on every patient to improve CT image quality and confidence in localizing disease in the pelvis.


C O N T R A S T A N D R E S O L U T I O N

F O R A L L P E T T R A C E R S


Low noise imaging demonstrate excellent image Quality

Excellent image quality and small lesions detectability

Ga-68 DOTATATE

Left- 6 mCi / 222 MBq Injection- 78 min uptake- 2.6mCi / 96 MBq at Scan Time

Right- 6.7 mCi / 248 MBq Injection- 104 min uptake- 2.2 mCi / 81 MBq at scan time

PET Radiopharmaceutical may not be approved by ministers of health in all regions


½ T I M E , N O C O M P R O M I S E


½ acquisition time6 min

Full acquisition time12 min

SUVmax: 7.45 Liver SUVmean: 2.07 SUVmax: 7.53 Liver SUVmean: 2.01

½ acquisition time6 min

Full acquisition time12 min

DISCOVERY MI sensitivity and LightBurst Digital detector provide reliable and consistent image quality, resolution and quantitative accuracy. With Discovery MI, research center will be able to free up scanner time for their research study without impact their daily clinical workload.


S M A L L L E S I O N D E T E C T A B I L I T Y


SUVmax: 3.7SUVmax: 7.4

LightBurst Digital Conventional PETLightBurst Digital Conventional PET

DISCOVERY MI sensitivity and LightBurst Digital detector provide improvement in small lesion detectability giving you increased confidence in your communications to referring physicians.


E X C E L L E N T I M A G E Q U A L I T Y

A N D C L I N I C A L R E S O L U T I O N


Liver SUVmean: 2.22 g/ml

Liver Noise (STD): 0.17 g/ml

DISCOVERY MI sensitivity and 20cm Axial Field of View LightBurst Digital detector provide the ability to perform fast 2 meter scans without sacrificing image quality or resolution and improve patient comfort with shorter scan times.

2 0 m i n u t e s

3 8 3 M B q / 1 0 . 3 5 m C i F D G



P a t i e n t r e f e r r e d t o P E T / C T f o r

R e s t a g i n g o f M a n t l e C e l l N o n -

H o d g k i n ’ s L y m p h o m a


2 8 . 4

P a t i e n t B M I





1 0 m i n u t e s

3 8 8 M B q / 1 0 . 5 m C i F D G



P a t i e n t r e f e r r e d t o P E T / C T f o r

e v a l u a t i o n a n d l o c a l i z a t i o n o f

e p i l e p s y f o c i


3 0 . 1

P a t i e n t B M I DISCOVERY MI sensitivity and 20cm Axial Field of View LightBurst Digital detector provide the excellent image quality and clinical resolution necessary for complex neurology cases where the slightest changes in uptake can be the guide for Neurosurgeons.


C O N T R A S T A N D R E S O L U T I O N

F O R A L L P E T T R A C E R S

Low noise imaging demonstrate excellent image qualityCourtesy PET Center Uppsala



Patient referred to PET/CT for evaluation of Alzheimer’sdiseases

1 9 6 M B q / 5 . 3 m C i F D G






2 0 m i n u t e s

2 7 0 M B q / 7 . 3 m C i 1 8 F - N a F

1 1 3 m i n u t e u p t a k e


P a t i e n t w i t h h i s t o r y o f P r o s t a t e

c a n c e r r e f e r r e d t o P E T / C T f o r

H i s t o r y o f p r o s t a t e c a n c e r w i t h

n e w b o n e p a i n . E v a l u a t i o n o f

m e t a s t a t i c d i s e a s e .


2 7 . 4

P a t i e n t B M I

DISCOVERY MI sensitivity and clinical resolution provide small lesion detectability for small bone lesions.



S M A L L L E S I O N D E T E C T A B I L I T Y

Courtesy PET Center Uppsala



P a t i e n t r e f e r r e d t o P E T / C T f o r e v a l u a t i o n o f m e t a s t a t i c p r o s t a t e c a n c e r .

2 6 . 7

P a t i e n t B M I

1 2 m i n u t e s

2 7 0 M B q / 7 . 3 m C i 1 8 F - N a F

1 1 3 m i n u t e u p t a k e



Grow patient volumes as referring physicians value the accurate, reproducible results and diagnostic confidence you deliver

QUANTITATIVE SUV YOU AND YOUR PATIENTS CAN TRUST

Improve communication with improved quantitation

More accurately assess treatment response to guide your treatment planning decisions with more accurate SUVs


Instrumentation

Physiology~15%

~35%

SUV

Calibration/QC

PVE

Motion

Reconstruction

Segmentation

Q.SUV

Q U A N T I T A T I V E P E T C H A L L E N G E S


FBP

2D/3D

VUE POINT

OSEM - HD OSEM - TOF OSEM - TOF + PSF

Q.CLEAR

BSREM

I M A G E Q U A L I T YI M A G E Q U A L I T Y

& Q U A N T I T A T I O N

I T E R A T I V E R E C O N S T R U C T I O N


IMAGE QUALITY DETERIORATES WITH MORE THAN A FEW ITERATIONS

1 Iteration 2 Iterations 15 terations 25 Iterations

BMI: 52.5 | ROI: 15mm | OSEM

SNR: 14.0 SNR: 8.0 SNR: 7.1

SUV 4.2 SUV 8.2 SUV 12.8

SNR : 16.4

SUV 13.5

I T E R A T I V E R E C O N S T R U C T I O N C H A L L E N G E S


FULL CONVERGENCE PET RECONSTRUCTION

2 Iterations 25 Iterations 25 Iterations

SUV 8.2 SUV 13.5 Q.SUV 14.0

BMI: 52.5 | ROI: 15mm | OSEM

SNR: 16.4 SNR: 35.0SNR : 7.1

Q . C L E A R A N D Q . S U V


MORE ACCURATE AND CONSISTENT QUANTITATION WITHINTELLIGENT NOISE CONTROL. EVERY VOXEL. EVERY STEP.

No noise control

One-size-fits-all noise control

Scanner Modeling

Object Modeling Filter

Partially converged SUVs

Recon LoopRecon Loop-3x 25x

Compromised image quality

Conventional Iterative Reconstruction Q.Clear

C O N S I S T E N T Q U A N T I T A T I O N

Noise Modeling

Scanner Modeling

Object Modeling


UP TO 2X IMPROVEMENT IN IMAGE QUALITY (SNR)

Standard

Q.Clear

Q.Clear

18F-FDG 3D MIP PET View

Images acquired on Discovery IQ equivalent system

• I N C R E A S E C L I N I C A L S E N S I T I V I T Y

• C O N F I D E N T L Y D E T E C T S M A L L M E TA S TAT I C D I S E A S E

• I M P R O V E D Q U A N T I TAT I V E A C C U R A C Y

C O N S I S T E N T Q U A N T I T A T I O N


SUV difference between Q.Clear and OSEM (TOF+PSF)

Partial volume error reduction

-2.0 g/mL 2.0 g/mL

F U L L C O N V E R G E N C E

N O C O M P R O M I S E


Q . S T A T I C

One-click PET protocolwith prospective reconstruction

Based on static WB workflowfor a static image series output

Reduces motion blurringfor quantitative consistency


Static PET 4D-PET Q.Freeze

SPHERES MOTIONSPHERES SUV RECOVERY SPHERES VOLUME RECOVERY

Q . F R E E Z EO N E I M A G E . A L L T H E C O U N T S . M O T I O N E L I M I N A T E D .


Q.FreezeWhole-body PET/CT Integrated 4D PET/CT

SUV = 4.2 g/mL SUV = 12 g/mL

10 min 24 min 12 min

Axial FOV: 15.6 cm Overlap: 23%TotalFOV: 28 cm

Q . F R E E Z EF U L L T H O R A X C O V E R A G E F O R E V E R Y P A T I E N T


SUV 3.8 g/mL SUV 3.7 g/mL

Best 4D bin

Whole-body PET/CT Integrated 4D PET/CT Q.Freeze

Q . F R E E Z EF U L L T H O R A X C O V E R A G E F O R E V E R Y P A T I E N T


discovery mi€¦ · the lcd measured in 0.625 mm slices and tested for both head and body modes...

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