Dionisia M. Quiroga, D.O, Ph.D Dionisia.Quiroga@osumc.edu

POST-GRADUATE TRAINING Resident Physician, Physician Scientist Training Program/Internal Medicine Program (June 2016 - present) The Ohio State University, Columbus, Ohio EDUCATION D.O., Doctor of Osteopathic Medicine (May 2016) Michigan State University, East Lansing, Michigan Ph.D., Cell and Molecular Biology (October 2014) Michigan State University, East Lansing, Michigan Dissertation: Enhancement of recombinant adenovirus vector vaccine efficacy by innate immune modulation Advisor: Andrea Amalfitano, D.O., Ph.D. B.S., Physiology (May 2007) Specialization in Bioethics, Humanities, and Society Michigan State University, East Lansing, Michigan ACADEMIC AND PROFESSIONAL HONORS

American Society of Clinical Oncology/Conquer Cancer Foundation Rotation Award (2015-2016) One of seven students nationally to receive fellowship funding for a two-month clinical research rotation; work will specifically involve patients receiving therapeutic cancer vaccines (including the vector utilized in Ph.D dissertation) at Duke University

National Institutes of Health NIGMS Ancillary Training Program Travel Scholarship (2015) One of two students nationally to receive this scholarship to present their translational research at “The Modes of Action of Vaccine Adjuvant” Keystone Symposia in Seattle, WA

American Medical Association Seed Grant Recipient (2013-2014) Competitive scholarship in which 28 total medical students, interns, and residents were selected to receive funds for initiation of novel research projects in the areas of cardiovascular/pulmonary disease, HIV/AIDS, or pancreatic cancer

Michigan State University Rasmussen Doctoral Recruitment Fellowship (2007) Incentive fellowship received upon enrolling in the Michigan State University Physician Scientist D.O./Ph.D program for medical and graduate school training

MEMBERSHIPS IN PROFESSIONAL SOCIETIES

- American Society of Clinical Oncology (ASCO) Member, 2015 – Present - American Medical Association (AMA) Member, 2009 – Present - American Osteopathic Association (AOA) Member, 2007 – 2016 - American Physician Scientist Association (APSA) Member, 2007 – Present - APSA Public Relations Committee Member/Newsletter Editor, 2008 – 2009 - American Association for the Advancement of Science (AAAS)/Science Program for Excellence in Science,

Member, 2008 – 2009

ACADEMIC POSITIONS AND ACTIVITIES The Ohio State University Editor, Reactome (2017)

- Edited an online database module describing interleukin-12 signaling for an open-access curated pathway database

Michigan State University Graduate Research Assistant, Cell and Molecular Biology Program (2007-2014) - Conducted basic and translational research focused on the development of novel cancer and HIV vaccine

platforms; under the direction of Dr. Andrea Amalfitano - Other research topics investigated include: HIV/AIDS patients poorly responsive to current therapies,

immunogenetics of ankylosing spondylitis, and mammalian Toll-like receptor innate immune responses - Taught >10 undergraduate and junior graduate students the methodology of preparing biological samples,

running genetic and immunologic laboratory tests, and analyzing/presenting/reporting data obtained from these experiments

Vice President of External Affairs, Council of Graduate Students (2013-2014) - Elected as academic government board member to represent the >11,000 graduate, medical, and other

professional students at the university (also served as program representative for 2 years prior) - Met with the university president, deans, and other faculty members to advocate for a wide variety of

graduate/professional student rights, resources, and representation - Specific accomplishments include:

o Helped to obtain a $6.2 million renovation to re-open a historic campus building as a graduate/professional student center by speaking to and receiving approval from the Michigan State University Board of Trustees

o Served as an initial committee member on the Tobacco Free MSU Task Force, which has since successfully enacted a university-wide tobacco-free ordinance (effective August 2016)

o Lobbied for appropriate university student health insurance coverage/services following passage of the Affordable Care Act

Site Staff Advisor, Alternative Spring Break Program (2010, 2011) - Led groups of eleven undergraduate students on volunteer projects involving HIV/AIDS prevention and

patient advocacy through local groups in Birmingham, AL and Washington, DC

Teaching Assistant, HM 561 – Basic Principles of Pathology (2010) - One of two medical students selected to help teach the laboratory component of a first-year allopathic and

osteopathic medical student pathology course - Answered student questions involving the identification and analysis of gross and microscopic human

pathology specimens - Reviewed interactive pathology laboratory media and quiz material with course instructors

State/National Organizations

National Fellowship Application Reviewer, Graduate Women in Science (2013-2014) - Appointed as a senior graduate student researcher to review and critique graduate and post-doctoral

fellowship applications for a national women’s professional organization

Research Judge, Michigan Osteopathic Association Spring Scientific Convention (2012, 2015) - Reviewed abstracts and critiqued student, intern, and resident poster presentations at annual medical

research conference - Participated in convention planning committee for months prior to conference

PUBLICATIONS Peer-reviewed manuscripts

McMichael EL, Courtney NB, Duggan MC, Wesolowski R, Quiroga D, Kondadasula SV, Atwal LS, Bhave N, Luedke E, Jaime-Ramirez AC, Campbell AR, Mo X, Byrd JC, Carson, WE 3rd. Activation of the FcgammaReceptorIIIa on human natural killer cells leads to increased expression of functional interleukin-21 receptor. Oncoimmunology. 2017; 6(5): e1312045. Quiroga D, Aldhamen YA, Godbehere S, Harding L, Amalfitano A. Decreased vector gene expression from second generation, E2b-deleted Ad5 vaccines paradoxically intensifies pro-inflammatory immune responses. Clin Vaccine Immunol. 2017; 24(6): pii: e00061-17. Quiroga D, Lyerly HK, Morse MA. Deficient mismatch repair and the role of immunotherapy in metastatic colorectal cancer. Curr Treat Options Oncol. 2016; 17(8): 41.

Quiroga D, Aldhamen YA, Appledorn D, Godbehere S, Amalfitano A. Strengthened tumor antigen immune recognition by inclusion of a recombinant Eimeria antigen in therapeutic cancer vaccination. Cancer Immunol Immunother. 2015; 64(4): 479-491.

Aldhamen YA, Pepelyayeva Y, Rastall DPW, Seregin SS, Zervoudi E, Koumantou D, Aylsworth CF, Quiroga D, Godbehere S, Georgiadis D, Stratikos E, Amalfitano A. Autoimmune disease-associated variants of extracellular endoplasmic reticulum aminopeptidase 1 induce altered innate immune responses by human immune cells. J Innate Immun. 2015; 7(3): 275-289.

Seregin SS, Rastall DPW, Evnouchidou I, Aylsworth CF, Quiroga D, Kamal R, Godbehere-Roosa S, Blum CF, York IA, Stratikos E, Amalfitano A. Endoplasmic reticulum aminopeptidases-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens. Autoimmunity. 2013; 46(8): 497-508.

Seregin S, Aldhamen YA, Appledorn DM, Aylsworth CF, Godbehere S, Liu CJ, Quiroga D, Amalfitano A. TRIF is a critical negative regulator of TLR agonist mediated activation of dendritic cells in vivo. PLoS ONE. 2011; 6(7): e22064.

Appledorn D, Aldhamen YA, DePas W, Seregin S, Liu CJ, Schuldt N, Quach D, Quiroga D, Godbehere S, Zlatkin I, Kim S, McCormick JJ, Amalfitano A. A new adenovirus based vaccine vector expressing an Eimeria tenella derived TLR agonist improves cellular immune responses to an antigenic target. PLoS ONE. 2010; 5(3): e9579.

National conference presentations Quiroga D, Aldhamen YA, Appledorn D, Godbehere S, Amalfitano A. Strengthened tumor antigen immune recognition by inclusion of a recombinant Eimeria antigen in therapeutic cancer vaccination. Keystone Symposia – The Modes of Action of Vaccine Adjuvants. Seattle, WA. October 2014; poster presentation.

Quiroga D, Uhal BD. Evaluating siRNA-mediated gene knockdown to study angiotensin-converting enzyme 2 function in mouse lung epithelial cells. National McNair Research Conference. Delavan, WI. November 2006; oral presentation.