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    Lecture 15

    BIOL L100Indiana University Southeast

    David Partin, Instructor

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    Todays Plan:

    Announcements/Questions

    Lecture 15: Physiology overview(immunity, digestion, urination, support &

    locomotion)

    One Minute paper

    Lab: Dissection!

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    Layout of the Lymphatic System

    Path of lymph?

    Where are lymphocytesmade?

    What are lymph nodes?

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    Part I

    Chapter 35:

    Immune System

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    Tissues of the Immune System

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    The Immune Response

    1

    2

    3

    4

    5

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    B lymphocytes are made in the bone marrow and mature in lymph nodes.

    Definitions: antigen vs antibody

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    T lymphocytes are madeand mature in the thymus.

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    T cells puncture target cells, causing damage to their cell membranes andeventually death of the target cell.

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    ABO blood antigens: your plasma containsno antibodies against the antigens foundon your blood cells.

    Rh + or - ??

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    The same

    principleapplies torejectedorgantransplantsand blood

    transfusions.

    Moms immune system recognizes

    that these cells are not like hers, sothe babys blood cells are attacked.

    Example of the immune system gonewrong

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    Part II

    Chapter 36:

    Digestive System

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    Digestive System

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    peristalsis

    Breathing orswallowing, butnot at the same

    time...

    Digestion begins inthe mouth:amylase breaksdown starch

    (carbohydrates).

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    made up of gastricglands

    coated with mucusproduces acid (killsmost bacteria)

    Enzymes breakdown protein

    Stomach

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    Large intestine

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    Nutrients enter the bloodstream

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    Other organs of the digestive system

    Liver Bile production assists in fat, carbohydrate and

    protein digestion

    Monitors blood immediately after digestion Gall bladder

    Holds livers bile and releases into theduodenum

    Pancreas Secretes juices into duodenum that assist in

    digesting fats, carbohydrates and proteins.

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    Need a break?

    Thanks for your attention!

    Take 10 minutes.

    Whats next?

    Urinary system

    Locomotion & Support

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    Part III

    Chapter 38:

    Urinary System

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    Urinary system

    Very importantfor themaintenance ofhomeostasis

    1- Fluidregulation(hydration &blood pressure)

    2- rids body ofwaste

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    Kidney structure

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    Bowmans capsule-

    Glomerulus-

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    Kidney structure

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    Renin-angiotensin-aldosterone system of blood pressure regulation

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    Part IV

    Chapter 41:

    Musculoskeletal System

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    The Human Skeletal System

    The skeleton supports and protects thebody.

    The skeleton also allows for flexiblemovements.

    Bones serve as storage units for calcium

    and phosphate. Blood cells are produced in some bones.

    Calcium & phosphate are stored in a solid

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    Important cells inbone formation:

    -osteoblasts:immature cells.

    -osteocytes:mature bone-producing cells.

    -osteoclasts:mature bone-

    degrading cells.

    Calcium & phosphate are stored in a solidform (bone) by osteocytes.

    When low levels of free calcium orphosphate are detected in the blood,osteoclasts break down bone and release

    these minerals into the bloodstream.

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    The Human Muscular System

    There are 3 main types of muscle cells:

    Skeletal

    Smooth

    Cardiac

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    Muscle cell = muscle fiber =myoctye

    Myofibril = bundleof contractileproteins

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    Step 1- An action potential causes

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    the motor neuron to dump itssynaptic vesicles into the synapticcleft.

    Step 2- Neurotransmitters from thesynaptic vesicles bind to receptorson the muscle cell membrane,opening Na+ channels.

    Step 3- The charge inside themuscle cell changes because of allthe Na+ rushing in. SR releases

    stored Ca+ which helps actin &myosin to form cross bridges.

    Step 4- K+ rushes out of the musclecell to help bring the charge back tonormal. SR stops releasing Ca+

    because charge is normal again.

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    Need a break?

    Thanks for your attention!

    Take 10 minutes.

    Whats next?

    1-minute paper

    Lab

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    Preparation for Lecture 16

    Read Ch 39 (starting with human nervoussystem on page 699)

    Ch. 40: pages 720-21, 723-26, 728-30