dic(disseminated intravascular...

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DIC(Disseminated intravascular coagulation) 4A2 王春月 2006-7-1 ㄧ、定義: DIC 是由於某些原因產生足以活化血液凝固的東西,進入血流內引發全身性 血管內凝血現象。例如嚴重敗血症和急性腫瘤產生 Thromboplastin-like 物質, 或引起血管內皮細胞受損,進而活化血管內異常血液凝固;所產生的纖維蛋白造 成瀰漫性的血管末梢血栓、溶血性貧血,同時發生消耗性出血現象。急性 DIC 常 常併發出血和組織器官壞死衰竭的症狀。 二、病理機轉: 1

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DICDisseminated intravascular coagulation

4A2 2006-7-1

DIC

Thromboplastin-like

DIC

1

Systemic activation of coagulation systemdiffuse thrombosishemolysisthrombolysis

Excessive consumption of coagulation factor >70bleeding tendency

()

1. thrombosisMOF

2. ()

2

DIC

tissue factor DIC :

ARDS

DIC

DICPT/PTT fibrinogenfactor 5

8 FDPD-Ddimmer3P test +

3

DIC ALP PT/PTT

fibrinogen factor 58

FDPD-Ddimmer3P test +

DICPT/PTT

fibrinogenfactor 58

D-Ddimmer3P test +

DIC PT/PTT Low antithrombin

Low fibrinogen

58FDP10- 20mg/mlpositive 3P Test

High D-D dimmer concertration DIC

DIC :

: SIRSDIC

(MODS)

SIRSDICMODS

DIC DIC

4

PLTFFPCryo

Heparin therapy heparin

2,0000U/24hrs

DIC heparin

fibrinolytic process

transamin

FOY thrombin and PLT aggregation 20-40mg/kg/24hr

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