diabetic foot ulcers diabetic foot ulcer treatment and prevention
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Diabetic Foot Ulcer Treatment and
PreventionAlexander Reyzelman DPM, FACFAS
Associate Professor California School of Podiatric Medicine at
Samuel Merritt University
Diabetic Foot Ulcers
� One of the most common complications of diabetes
� Annual incidence 1% to 4%1-2
� Lifetime risk 15% to 25%3-4
� ~15% of diabetic foot ulcers result in lower extremity amputation3,5
� ~85% of lower limb amputations in patients with diabetes are proceeded by ulceration6-7
� Peripheral neuropathy is a major contributing factor in diabetic foot ulcers1-7
� Other factors: foot deformity, callus, trauma, and peripheral vascular disease
1. Reiber and Ledoux. In The Evidence Base for Diabetes Care. Williams et al, eds. Hoboken, NJ: John Wiley & Sons 2002:641.
2. Boulton et al. NEJM. 2004;351:48.3. Sanders. J Am Podiatry Med Assoc. 1994;84:322.
4. Boulton et al. Lancet. 2005;366:1719.5. Ramsey et al. Diabetes Care 1999;22:382.6. Pecoraro et al. Diabetes Care. 1990;13:513.7. Apelqvist and Larsson. Diabetes Metab Res Rev.
2000:16:S75.
5-Year Mortality Rates
Armstrong et al. Int Wound J. 2007;Dec;4(4):286.
CA = Carcinoma.PAD = Peripheral artery disease.
In order to treat wounds, we must understand the factors associated with the etiology of those
wounds
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Wagner Classification
� Stage 0- pre-ulcerative lesion� Stage I- superficial with exposed sub Q� Stage II- down to tendon, ligament or
bone, not infected� Stage III- infected� Stage IV- localized gangrene of forefoot� Stage V - extensive gangrene
UT Diabetic Wound Classification System
0 1 2 3
A Pre orpostulcerative
lesion(epithelialized)
Superficial, notinvolving tendon,capsule or bone
Penetrates totendon orcapsule
Penetrates toBone
B INFECTION INFECTION INFECTION INFECTION
C ISCHEMIA ISCHEMIA ISCHEMIA ISCHEMIA
D INFECTION andISCHEMIA
INFECTION andISCHEMIA
INFECTION andISCHEMIA
INFECTION andISCHEMIA
1. Consensus Development Conference on Diabetic Foot Wound Care. ADA. Diabetes Care. 1999;22:1354-1360.
STANDARD TREATMENT FOR
DIABETIC FOOT ULCERS
Standard treatment modalities 1
� Sharp debridement of nonviable tissue
� Treatment of infection
� Saline-moistened dressings
� Off-loading to decrease pressure on extremity
� Arterial revascularization if indicated
� A wound that remains unhealed after 4 weeks is cause for concern, as it is associated with unfavorable outcomes, including amputation
Debridement
1) Debridement reduces the bio-burden2) potentially prevents an infection3) allows for better visualization and inspection of the wound. Steed and coworkers reported in their multi-center study that the patients that underwent debridement showed an improved healing response compared to the patients who did not undergo
debridement.
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� Continue until healthy bleeding soft tissue and/or bone are encountered
� Callus tissue surrounding the ulcer must be removed
� Regular debridement, typically weekly, can expedite the rate of wound healing and increase the probability of wound closure
Infection
� Secondary Signs of Infection
� Chronic exudate� Delayed healing� Friable granulation
tissue� Discolored
granulation tissue� Malodor� pocketing
Risk Factors for Foot Infections in Individuals with Diabetes
Lavery, et al Diabetes Care, Vol 29, Number 6, June 2006
Statistically significant risk factors for foot infection
� Wound depth to bone� Wound duration >30 days� Recurrent foot wound� Traumatic wound etiology� Peripheral vascular diseaseThe risk of developing an infection was 2,193 times greater in
subjects who develop a foot wound than in those without a wound
Pressure
� Is there too much pressure on the wound/ulcer
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Unaffected Limb S/P Partial First Ray and Charcot Af fected Limb
Photograph and scans courtesy of John S. Steinberg, DPM, University of Texas Health Science Center at San Antonio, San Antonio, Tex.
PLANTAR PRESSURES AND ULCERATION
Gold-Standard
� TCC� Multiple reports in
literature discussing reduction of peak plantar pressure on the forefoot and midfoot.
Removable Walker Boots
� Aircast
� Bledsoe
� DH Walker
DH Walker CROW
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Healing of Neuropathic Ulcers: Results of a Meta-analysis
� These data provide clinicians with a realistic assessment of their chances of healing neuropathic ulcers
� Even with good, standard wound care, healing neuropathic ulcers in patients with diabetes continues to be a challenge
Margolis et al. Diabetes Care. 1999;22:692.
GOOD WOUND CARE x 4 weeks
50% Healed?
Continue with treatment
Change to “Advanced Wound Healing”
YES NO
Advanced Wound Management
Types of Products
� Negative Pressure � Collagen� Growth Factor
� Acellular Dermal Matrix� Bioengineered Skin
� Dermagraft� Apligraf
Protective Footwear:Permanent Shoes
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Thank YouTissue Engineering
Dermal fibroblasts are seeded ontoa bioabsorbable scaffold
After 2 weeks, a living dermal substitute has formed which can support the migration, proliferation and stratification of an epidermis
Growing living human dermal substitutes
*The persistence of Apligraf cells on the wound and the safety of this device in venous ulcer patients beyond 1 year and in diabetic foot ulcer patients beyond 6 months have not been evaluate
What is Apligraf?Product Description
� Supplied as a living, bi-layered skin substitute*Indications :
� Venous Leg Ulcers� Diabetic Foot Ulcers
Well-tolerated in over 12,000 patient applications
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Histological cross-section of DERMAGRAFT
DERMAGRAFT from the Package
Dermagraft ®