Diabetes Insipidus

By: Abigail Wells and Samantha Wright

What is it?

Loss of control of water balance

Kidneys do not reabsorb excess fluid

Tubules are not permeable to water

Person experiences excessive thirst & urination

Cause

Results from lack of vasopressin

Damage to hypothalamus or pituitary caused by histiocytes

Cause

Tumor in pituitary or hypothalamus

Inflammation of hypothalamus and pituitary

Osmoreceptors fail to work.

Diagnosis

Blood Glucose Levels

Bicarbonate Levels

Calcium Levels

Diagnosis

Fluid Depravation Test

Excessive fluid intake

Defect in ADH production

Defect in kidney response to ADH

Diagnosis

Changes in body weight

Urine output Urine composition No fluid given,

dehydration occurs

Diagnosis

Normal Response = more concentrated urine, less frequent urination

DI response = urinate large amounts of undiluted urine

Treatments

Desmopressin

Synthetic replacement for Vasopressin

Nasally, intravenously, pill

Treatments

Carbamazepine

Anti-convulsive medication

Had some success

Works Cited

http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/K/Kidneys.gif http://www.3dchem.com/imagesofmolecules/Vasopressin.jpg http://www.health-choices-for-life.com/images/

Pituitary_hypothalamus.jpg http://assets.aarp.org/external_sites/adam/graphics/images/en/

19825.jpg http://www.health.bcu.ac.uk/physiology/ADH2.gif http://scienceblogs.com/startswithabang/upload/2009/04/

putting_the_yellow_in_your_uri/urine-contents.jpg http://wwwdelivery.superstock.com/WI/223/1598/PreviewComp/

SuperStock_1598R-198877.jpg http://www.drugs.com/images/pills/mtm/DDAVP%200.1%20mg.jpg http://www.healthcentral.com/common/images/l/

LMM01090_46124_5.JPG