Devices And Combination Products For Neurodegenerative Diseases

Program Description Academic and, to a lesser extent, commercial researchers are providing game-changing perspectives for compelling commercial and clinical therapies as potential solutions. The recent MDG “Year of the Brain Symposium” addressed many of these groundbreaking developments.This MDG Neurodegenerative Forum will focus on the resources of active med device and life science entrepreneurs, clinical and R&D organizations addressing businesses that can make a difference. For this Forum, we will focus on Alzheimer’s Disease. Jim Wessler, President & CEO of the MA/NH Chapter of the Alzheimer’s Association, will address us from the perspective of an advocate for patients. Dr. Anil K. Nair, MD, Chief, Neurology and Director, The Alzheimer’s Center at Carney Hospital, whose opinion is recognized internationally, will speak as a clinician treating patients. Cornelia B. Reininger, MD, PhD, Senior Vice President and Chief Medical Officer, Navidea Biopharmaceuticals, an emerging company in the Boston Area, will discuss development of precision imaging agents for the diagnosis of neurologic disease.

The broad spectrum of neurodegenera-tive diseases (Lou Gehrig’s, Parkinson’s, Alzheimer’s Disease, Multiple Sclerosis, and others) represent a steep scientific and business challenge for medtech, biotech and pharmaceutical companies

Neurodegenerative diseases affect millions of people worldwide: for example, more than five million Americans are living with Alzheimer’s disease, and at least 500,000 with Parkinson’s disease.

The Harvard Neuro Discovery Center says: “The numbers … 5 million suffer from Alzheimer’s Disease, 1 million from Parkinson’s, 400,000 from Multiple Sclerosis (MS), 30,000 from amyotrophic lateral sclerosis (ALS), 30,000 from Huntington’s. These mid- to late-life diseases are expected to soar as the population ages.

Wednesday Feb 4, 2015 5:30 – 9:00 PMConstant Contact Waltham, MA

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Agenda5:30 Networking, Food, Refreshments6:00 Program Introduction-Moderator 6:20 – 7:15 Speaker Presentations 7:20 – 8:20 Audience Breakout Dis-cussions and Reports8:20 – 8:30 Moderated Panel Q&A8:30 Summation, Networking for all with Presenters and each other9:00 Depart

Upcoming EventsWed Mar 4: 5:30 – 8:30 PM Combination Products - Diversity in Type and Application (Constant Contact)

Wed, April 1: 5:30 - 8:30 PM The Surgical Suite Responds to the New Business Model of Healthcare (Constant Contact)

Wed April 29: 3:30 – 8:00 PM SPECIAL EVENT: Connecting Medical Products to the Internet of Things (IOT) (Foley Hoag Law Offices South Boston, MA)

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Jim Wessler President and CEO of the Alzheimer’s Association, Massachusetts/New Hampshire Chapter

Since he started there in 1998, the Massachusetts/New Hampshire Chapter has grown to one of the largest and most effective chapters of the Alzheimer’s Association, directly serving over 35,000 people annually. The MA/NH chapter is an independent, private, not-for-profit corporation with over 60 employees and an operating

budget of $7 million annually. For more than 35 years Jim has worked in the not-for-profit sector in New England, with leadership positions in the areas of community advocacy, affordable housing and elder health care. He received his bachelor’s from Harvard College and his MBA from Boston University. Jim is a resident of Newton.

Cornelia B. Reininger, MD, PhD SVP and Chief Medical Officer Navidea Biopharmaceuticals

Dr. Reininger is responsible for Pharmacovigilance, Clinical Operations and Medical Affairs at Navidea. Prior to Navidea, Dr. Reininger served as Senior Director of Clinical Research and Global Clinical Leader of Bayer Healthcare Pharmaceuticals’ Alzheimer’s and amyloid PET imaging development programs. Early in her career, Dr. Reininger served in roles of increasing responsibility with the global medical organizations of GE Healthcare and Amersham Health – Diagnostic Imaging. She holds an Associate Professor of Surgery and External Lecturer position

at Ludwig Maximillian University (LMU) in Munich, Germany, where she completed her medical education and residency in general and vascular surgery. During her residency, Dr. Reininger was on staff at the LMU Downtown Surgical Hospital and Outpatient Clinic, rotating as Chief Resident in vascular surgery and the intensive Care Unit. She later became the head of the hospital’s thrombosis research laboratory. Dr. Reininger is a member of the Society of Nuclear Medicine and the European Association of Nuclear Medicine.

Anil K. Nair MD Chief of Neurology and Director of Alzheimer’s Center Carney Hospital

Dr. Nair is a nationally recognized key opinion leader in neurodegenerative diseases. His interest area is in early and preclinical detection, prevention and treatment of Alzheimer’s disease and other neurocognitive disorders or dementias. He completed his fellowship at Mayo Clinic, Rochester, MN, and neurology residency at the

Cleveland Clinic and Temple University. In addition he is a neurologist for the Framingham Heart Study, is the Chairman of the Certification Exam Committee at United Council of Neurologic Sub-Specialities, and Councilor for the Geriatric Neurology Executive Committee at the American Academy of Neurology

Panelists

Co-Champions

Paul Hartung, Cognoptix President and CEO (Moderator)

Richard O’Brien, Principal, Nagog Hill Partners

ModeratorPaul Hartung Chairman, President and CEO Cognoptix, Inc.

Paul is a long-time life sciences executive with a proven track record in launching successful startup businesses and leading Fortune 500 organizations. As CEO of Cognoptix, he has raised over $32 million for the development of an innovative eye scan for early detection of Alzheimer’s disease, obtaining initial funding and moving the company from concept through clinical

trials. He has extensive experience in the laser and medical device industries, including managing manufacturing for Summit Technology, a leading developer of the LASIK procedure. Paul serves on the Board of Directors of MDG. He graduated from MIT with an MS Degree in Mechanical Engineering. He is an active speaker, author and inventor on a number of patents.

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MDG Officers, 2013-2014President Peter Madras pmadras@mdgboston.orgSecretary Jerrold M. Shaprio, PhD jshapiro@mdgboston.org Treasurer Peter Fuchs pfuchs@mdgboston.org

MDG Board of DirectorsPaul Hartung phartung@mdgboston.orgWilliam McIlhargey wmcilhargey@mdgboston.org Lisa Sasso lsasso@mdgboston.orgAshley Sherman asherman@mdgboston.orgAnna Xia axia@mdgboston.org

MDG Special Interest Groups Diagnostics John Wyatt john.wyatt02@gmail.comEntrepreneurial & Clinical Roy Coleman rcoleman@iandiorio.com Marketing & Sales SIG John Knott johnk@jdtechsales.comDavid Hamacher davidh@getbettersales.comMedical Software Eric Poole eric@rkt-tech.com Product Development SIG Michael Aprea, Co-Chair maprea-sdw@cox.netKevin Pelletier, Co-Chair kpelletier@massmaterials.com

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MDG Committee Co-ChairsProgram Central Ed Dolan, Co-Chair edolan@mdgboston.orgJoe Berkowitz, Co-Chair Networking jberkowitz@mdgboston.orgMichael Mills, Co-Chair Networking MJDMills@gmail.comEvent Operations David Ennen dennen@mdgboston.orgMembership Paul Hartung phartung@mdgboston.orgPartners & Alliances Alan Kivnik akivnik@mdgboston.orgSponsorship Joe Berkowitz jberkowitz@mdgboston.orgJon Nugent jnugent@mdgboston.orgAshley Sherman asherman@mdgboston.orgLeaders/Resources

Marie Cloutier (Membership) marie@mariec.com Jeff Karg (Program Central) jeff.karg@techen.con Sean Phillips (Membership) sean@rocketsd.comTom Rose (Membership) ftom.rose@gmail.comLife Science Nation: Dennis Ford,CEO, Jack Fuller, Bus Dev’t, tcrosby@lifesciencenation.com

FoleyHoag: David Pierson, Partner; Claire M. Lawless

MDG StaffDirector of Operations William Munger wmunger@mdgboston.org

MDG ConsultantsCPA Andrew S. GoloboyAdmin Support Patti Clark medicaldevicegroup4@gmail.comGraphic Design Bill Denison bill@denisondesigngroup.com

About MDG BostonMDG is the professional association for career building, knowledge acquisition and mutual support for New England medical technology professionals.

MDG sponsors Forums, Networking, SIGs (Special Interest Groups), Workshops and Special Events where diverse industry leaders can share their experience and knowledge as presenters and one-on-one.

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MDG Boston 2014-2015 Program Calendar

Forum Panels (Location: Constant Contact Headquarters, Waltham, unless noted otherwise)

Sept 10 Bringing Bionics To Life Co-Champions: Kevin Franck, Dan Healey

Oct 1 Intellectual Property Approaches To Safeguard Value Co-Champions: Rob Adelson, Roy Coleman, Stanley Chalvire

Nov 5 Optical Cancer Detection: 20 years of Lessons Learned and 20 Years Of Future Promise Co-Champions: Bob Andrews, Randy Chinnock

Dec 3 The Radical Transformation of Healthcare: The Rise Of Virtual Care Delivery Co-Champions: Kevin Fickenscher, MD, Shankar Krishnan, MD

Jan 7 Making Medical Technology More Human Co-Champions: Mike Wiklund, Sean Phillips

Feb 4 Devices And Combination Products For Neurodegenerative Disease Co-Champions: Paul Hartung, Richard O’Brien

Mar 4 Combination Devices: Diversity In Type And Application Co-Champions: John O’Gara, Rich Andrews

Apr 1 The Surgical Suite Responds to the New Business Model of Healthcare Co-Champions: Bill McIlhargey, Melvin Prenovitz

May 6 Advancing Women’s Health: Gender Centered Treatments for What Worries Women Co-Champions: Anna Xia, Jerry Shapiro

June 3 Keep It Agile – Keep It Legal Co-Champions: Eric Poole, Jeff Karg

Member NewsMDG welcomes these new members:

Tim Coonahan Thomas Farb Elizabeth Kelly Colm Lawler Prakash Manandhar Kristofer Munroe Adrian Timmers Geoff Waite Mikayla Pasciuto Jigar Parikh

In addition, we welcome back those who have renewed their MDG membership:

Robert Baker Roy Coleman Eric Cunningham Thomas Doucette Richard Hart Paul Hartung Gordon Hirschman

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Mike Mazzola Jigar Parikh Bennett (Ben) Rockney Thomas Root Ed Ross Peter Stokes Ashok Subramanian