Department of Department of PharmacologyPharmacology

Overview 2007-2008Overview 2007-2008

Heidi E. Hamm, Ph.D.Heidi E. Hamm, Ph.D.Earl W. Sutherland, Jr. Professor of Earl W. Sutherland, Jr. Professor of

PharmacologyPharmacologyChair, Department of PharmacologyChair, Department of Pharmacology

Pharmacology FacultyPharmacology Faculty

PHARMACOLOGY

NeuroscienceBlakelyEmesonLevittGurevichShiehStanwoodKonradi

Current searchSynaptic electro-physiologist

Drug Discovery

ConnForsterWeaverLindsley

Future searchDMPK with Clin Pharm

Clinical PharmacologyRobertsBrashRodenOatesBrownSchneiderKnollmanMundyDavies

Structural Biology

GurevichHammIverson Spiller

Systems Biology

ChungBrownHammForster

Receptors & Signal

TransductionHammSanders-BushConnGurevichBrownBarnettWadzinski

Pharmacology RecruitmentPharmacology Recruitment

• 20072007 Sean DaviesSean Davies• 20082008 Christine KonradiChristine Konradi

• Current Recruitment:Current Recruitment: neuroscience – neuroscience – synaptic electrophysiologistsynaptic electrophysiologist

• Targets of opportunity: Jon SchoeneckerTargets of opportunity: Jon SchoeneckerAna CarneiroAna CarneiroCarrie JonesCarrie Jones

• Future Recruitments: signal transduction Future Recruitments: signal transduction cancer pharmacologycancer pharmacologydrug dispositiondrug dispositionsystems biologysystems biology

Our New Our New FacultyFaculty Recruits Recruits

• Sean DaviesSean Davies studies the lipid studies the lipid products of oxidative stress, the products of oxidative stress, the isoketalsisoketals

• He is a joint recruit with Clinical He is a joint recruit with Clinical PharmacologyPharmacology

• He recently received the He recently received the 2007 NIH 2007 NIH Director’s New Innovator AwardDirector’s New Innovator Award to to develop better long-term treatment develop better long-term treatment strategies for chronic diseases using strategies for chronic diseases using probiotic bacteria engineered to produce probiotic bacteria engineered to produce therapeutic compounds. therapeutic compounds.

Our New Faculty RecruitsOur New Faculty Recruits

• Christine Konradi Christine Konradi is a new Faculty is a new Faculty Member in Pharmacology – she Member in Pharmacology – she joined us from the Psychiatry joined us from the Psychiatry DepartmentDepartment

• She trained in the Univ. of Vienna, She trained in the Univ. of Vienna, the Univ. of Wurzburg, Univ. of the Univ. of Wurzburg, Univ. of Medicine and Dentistry of New Medicine and Dentistry of New Jersey, and the Mass General Jersey, and the Mass General Hospital, Harvard Med. School.Hospital, Harvard Med. School.

• Christine works on the role of psychostimulants in gene regulation in psychiatric disorders

• She has two R01 grants

How are we doing?How are we doing?

• ReputationReputation

• CitationsCitations

• NIH fundingNIH funding

• National Responsibilities & HonorsNational Responsibilities & Honors

• Leadership rolesLeadership roles

0

5,000,000

10,000,000

15,000,000

20,000,000

25,000,000

30,000,000

35,000,000

1998 #2 1999 #1 2000 #6 2001 #15

2002 #2 2003 #4 2004 #6 2005 #4 2006 2007 2008 2009 est

Pending ApprovedFY09Other FundingNIH Funding to PharmPharmacology FundingPharmacology Funding

1998 - 20081998 - 2008

We’ve had an We’ve had an incredibleincredible year! year!

Pharmacology Funding withPharmacology Funding withDrug Discovery HighlightedDrug Discovery Highlighted

0

5,000,000

10,000,000

15,000,000

20,000,000

25,000,000

30,000,000

35,000,000

1998 #2 1999 #1 2000 #6 2001 #15

2002 #2 2003 #4 2004 #6 2005 #4 2006 2007 2008 2009 est

Drug Discovery Funding

"Pharm Funding"

Ratio of $ Awarded to Ratio of $ Awarded to Development $ SpentDevelopment $ Spent

(Average ROI is $8 awarded to every $1 spent in (Average ROI is $8 awarded to every $1 spent in development)development)

-5,000,000

0

5,000,000

10,000,000

15,000,000

20,000,000

25,000,000

30,000,000

FY01 FY02 FY03 FY04 FY05 FY06 FY07 FY08 FY09 Est

Development $ Spent Awards Growth from Base

New GrantsNew Grants

2007-8: Our Faculty Have 2007-8: Our Faculty Have Obtained National Grants Obtained National Grants

and Awardsand Awards

• Craig LindsleyCraig Lindsley is PI on a is PI on a MLPCN Chemistry Center MLPCN Chemistry Center Grant for $18M! This is one Grant for $18M! This is one of only two in the country.of only two in the country.

• He also has 2 new R01sHe also has 2 new R01s

National Grants and AwardsNational Grants and Awards

• Jeff ConnJeff Conn has received large grants has received large grants from the Michael J. Fox Foundation from the Michael J. Fox Foundation for Parkinson’s Research and from for Parkinson’s Research and from Seaside Therapeutics for studies of Seaside Therapeutics for studies of Fragile-X SyndromeFragile-X Syndrome

• He also has 5 R01 grantsHe also has 5 R01 grants

National Grants and National Grants and AwardsAwards

• Randy BlakelyRandy Blakely received a NIMH Conte received a NIMH Conte Center grant on Genes Controlling Center grant on Genes Controlling Assembly and Function of Serotonin Assembly and Function of Serotonin Systems. Participants include Elaine Systems. Participants include Elaine Sanders-Bush, Pat Levitt, Ron Emeson, Sanders-Bush, Pat Levitt, Ron Emeson, Doug McMahon and Evan Deneris Doug McMahon and Evan Deneris

• Randy also has a R37 MERIT award, a R01 Randy also has a R37 MERIT award, a R01 grant, and a PPG on Presynaptic Choline grant, and a PPG on Presynaptic Choline Transporters, Transporters, as well as a training grantas well as a training grant

National Grants and AwardsNational Grants and Awards

• Heidi HammHeidi Hamm is part of a Specialized is part of a Specialized Center of Clinically Oriented Research Center of Clinically Oriented Research (SCCOR) on Thrombosis from NHLBI (SCCOR) on Thrombosis from NHLBI to study Thrombin Signaling in to study Thrombin Signaling in PlateletsPlatelets

• She also has 3 R01sShe also has 3 R01s

National Grants and AwardsNational Grants and Awards

• Alex BrownAlex Brown received a new “Systems received a new “Systems Biology of Infectious Disease” Grant to Biology of Infectious Disease” Grant to study influenza virus interaction with study influenza virus interaction with its host, with Alan Aderem of the its host, with Alan Aderem of the Institute for Systems BiologyInstitute for Systems Biology

• He also received the renewal of the He also received the renewal of the Lipid MAPS Glue Grant Lipid MAPS Glue Grant

National Grants and National Grants and AwardsAwards

• Vsevolod GurevichVsevolod Gurevich received a new received a new grant from NIGMS entitled grant from NIGMS entitled “Conformational regulation of “Conformational regulation of arrestin-mediated signaling”arrestin-mediated signaling”

• He also has two other R01 grantsHe also has two other R01 grants

National Grants and AwardsNational Grants and Awards

• Joey BarnettJoey Barnett is a part of the Systems-based is a part of the Systems-based Consortium for Organ Design and Consortium for Organ Design and Engineering (SysCODE)Engineering (SysCODE)

• He also has an R01 and an AHA grant, as He also has an R01 and an AHA grant, as well as two training grantswell as two training grants

• Brian WadzinskiBrian Wadzinski – renewed his NIGMS – renewed his NIGMS R01 grant on protein kinase/PP2A R01 grant on protein kinase/PP2A complexescomplexes

• He also has another R01 grantHe also has another R01 grant

• Eugenia GurevichEugenia Gurevich received a Michael J. Fox received a Michael J. Fox Foundation Grant Foundation Grant

National Grants and AwardsNational Grants and Awards

National Grants and AwardsNational Grants and Awards

• Tony ForsterTony Forster received a Pilot Grant received a Pilot Grant from the Vanderbilt Diabetes Centerfrom the Vanderbilt Diabetes Center

• He also has an R01 and an ACS He also has an R01 and an ACS Research ScholarResearch Scholar grantgrant

National Grants and AwardsNational Grants and Awards

• Tina IversonTina Iverson received a NARSAD award on received a NARSAD award on “Allosteric Nucleotide Exchange in G protein “Allosteric Nucleotide Exchange in G protein subunits” subunits”

• She also has an R01 grant and a VICB pilot She also has an R01 grant and a VICB pilot grant grant

National AwardsNational Awards

• Randy BlakelyRandy Blakely –– 2008 ASPET Julius 2008 ASPET Julius Axelrod Award; 2008 ASPET-Axelrod Award; 2008 ASPET-Astellas Award in Translational Astellas Award in Translational

PharmacologyPharmacology

•Jeff ConnJeff Conn -- PhARMA -- PhARMA Foundation Award for Excellence Foundation Award for Excellence in Pharmacology and Toxicologyin Pharmacology and Toxicology

National AwardsNational Awards

• Dan RodenDan Roden -- 2008 Rawls -- 2008 Rawls Palmer Award for Progress in Palmer Award for Progress in Medicine, American Society for Medicine, American Society for Clinical Pharmacology and Clinical Pharmacology and Therapeutics Therapeutics

•Joey BarnettJoey Barnett -- AHA Southeast -- AHA Southeast Affiliate Science Integration AwardAffiliate Science Integration Award

Our Faculty are Our Faculty are Distinguished Leaders Distinguished Leaders

NationallyNationally• MERIT awards: MERIT awards: Randy Blakely, Elaine Sanders-Bush, Randy Blakely, Elaine Sanders-Bush, Jack Roberts Jack Roberts

• Editor of Molecular Pharmacology, Editor of Molecular Pharmacology, Jeff Conn Jeff Conn

• Associate Editors of Molecular Pharmacology, Associate Editors of Molecular Pharmacology, Alex Alex Brown, Randy Blakely, Al GeorgeBrown, Randy Blakely, Al George

• NIH Peer Review Advisory Committee, Heidi HammHeidi Hamm

• HHMI Review Board,HHMI Review Board, Heidi HammHeidi Hamm

• President, American Society for Biochemistry & President, American Society for Biochemistry & Molecular Biology Molecular Biology Heidi HammHeidi Hamm

Our Faculty are Our Faculty are Distinguished Leaders Distinguished Leaders

Nationally, cont’dNationally, cont’d• Pat Levitt – Pat Levitt – NINDS Strategic Plan Committee; Chair, High NINDS Strategic Plan Committee; Chair, High Risk/High Impact Program Committee, Autism Speaks Risk/High Impact Program Committee, Autism Speaks Foundation; NIMH Blue Ribbon Panel on Intramural Foundation; NIMH Blue Ribbon Panel on Intramural Research Programs Research Programs

• Joey BarnettJoey Barnett -- co-chair April 2008: -- co-chair April 2008: Pharmacology Education Pharmacology Education for the Next 100 Years, San Diego, CA; for the Next 100 Years, San Diego, CA; Chair, American Heart Chair, American Heart Association Greater Southeast Affiliate Research CommitteeAssociation Greater Southeast Affiliate Research Committee

• Alex BrownAlex Brown, Organizer/Chair for FASEB meeting on , Organizer/Chair for FASEB meeting on Phospholipases, July 2008Phospholipases, July 2008

Our Faculty are Our Faculty are Distinguished Leaders Distinguished Leaders

Nationally, cont’dNationally, cont’d• Heidi HammHeidi Hamm -- Member, FASEB Science Policy -- Member, FASEB Science Policy Committee Peer Review Subcommittee; Board Committee Peer Review Subcommittee; Board Advisor, FASEB Excellence in Science Awards Advisor, FASEB Excellence in Science Awards Committee, 2007-08; Member, AAMC Panel on Committee, 2007-08; Member, AAMC Panel on Safe and Effective Prescribing PracticesSafe and Effective Prescribing Practices

• Jeff ConnJeff Conn: Chair,: Chair, Division of Neuropharmacology, Division of Neuropharmacology,

ASPET; Scientific advisory board member, ASPET; Scientific advisory board member, Stanley Center for Psychiatric Research, Broad Stanley Center for Psychiatric Research, Broad Institute; Technical Evaluation Panel, NIMH Institute; Technical Evaluation Panel, NIMH Program ReviewProgram Review

Our Faculty Receive Kudos Our Faculty Receive Kudos at homeat home

• Jeff ConnJeff Conn – named Lee – named Lee E. Limbird Professor of E. Limbird Professor of PharmacologyPharmacology

•Nancy Brown Nancy Brown - 2008 Elaine - 2008 Elaine Sanders-Bush Faculty Award Sanders-Bush Faculty Award for Mentoringfor Mentoring

Our Faculty Receive Kudos Our Faculty Receive Kudos at Homeat Home

• Joey BarnettJoey Barnett was elected to was elected to the Vanderbilt Academy for the Vanderbilt Academy for Excellence in Teaching Excellence in Teaching

Our Faculty are Campus Our Faculty are Campus LeadersLeaders

• Randy BlakelyRandy Blakely - Director, Center for Molecular - Director, Center for Molecular Neuroscience, Director, Vanderbilt/NIMH Silvio O. Neuroscience, Director, Vanderbilt/NIMH Silvio O. Conte Center for Neuroscience ResearchConte Center for Neuroscience Research

• Pat Levitt – Director, Kennedy CenterPat Levitt – Director, Kennedy Center

• Jeff ConnJeff Conn - Director, Program in Drug Discovery, - Director, Program in Drug Discovery, Director, Program in Translational Neuropharmacology Director, Program in Translational Neuropharmacology

• Dan Roden Dan Roden - Director, Oates Institute of Therapeutic - Director, Oates Institute of Therapeutic Discovery, Asst. Vice-Chancellor for Personalized Discovery, Asst. Vice-Chancellor for Personalized Medicine, Principal Investigator, Vanderbilt DNA Medicine, Principal Investigator, Vanderbilt DNA DatabaseDatabase

• Jack RobertsJack Roberts – Faculty Senate Vice Chair-Elect – Faculty Senate Vice Chair-Elect

Our Faculty are Campus Our Faculty are Campus Leaders, ContinuedLeaders, Continued

• Nancy BrownNancy Brown - Associate Dean for Clinical and Translational Scientist - Associate Dean for Clinical and Translational Scientist Development, Director, Vanderbilt (K12) Clinical Research Scholars Development, Director, Vanderbilt (K12) Clinical Research Scholars ProgramProgram

• Heidi HammHeidi Hamm - Internal Advisory Board, Vanderbilt University Vanderbilt - Internal Advisory Board, Vanderbilt University Vanderbilt

Institute for Clinical and Translational Research, CTSA; Medical Scientist Institute for Clinical and Translational Research, CTSA; Medical Scientist Training Program Faculty Advisory CommitteeTraining Program Faculty Advisory Committee

• Ron EmesonRon Emeson – Chair, Institutional Animal Care and Use Committee; – Chair, Institutional Animal Care and Use Committee; University Faculty Senate Academic Programs and Services CommitteeUniversity Faculty Senate Academic Programs and Services Committee

• Tina IversonTina Iverson serves on the Center for Structural Biology Executive serves on the Center for Structural Biology Executive Committee, as well as theCommittee, as well as the Chemical Biology Interface Training Grant Executive Chemical Biology Interface Training Grant Executive Committee Committee

• Gregg StanwoodGregg Stanwood is Associate Director, Vanderbilt Mouse Neurobehavioral is Associate Director, Vanderbilt Mouse Neurobehavioral CoreCore

Study Section MembersStudy Section Members

• Full MembersFull MembersJoey BarnettJoey BarnettRandy BlakelyRandy BlakelyAlex BrownAlex BrownChang ChungChang ChungSeva GurevichSeva GurevichRon EmesonRon EmesonCraig LindsleyCraig LindsleyChristine Christine

KonradiKonradi

• Ad-hoc MembersAd-hoc MembersTony ForsterTony Forster

We are Highly CitedWe are Highly Cited

• Vanderbilt ranks # 5 in The Most-Vanderbilt ranks # 5 in The Most-Cited Institutions in Pharmacology & Cited Institutions in Pharmacology & Toxicology, 1996-2006Toxicology, 1996-2006

A New Faculty Scholarly A New Faculty Scholarly Productivity IndexProductivity Index

• The index uses only objective criteria to calculate The index uses only objective criteria to calculate the scholarly productivity of individual faculty.the scholarly productivity of individual faculty.

• It rates faculty members' scholarly output at nearly It rates faculty members' scholarly output at nearly 7,300 doctoral programs around the country. 7,300 doctoral programs around the country.

• The index was devised by Lawrence B. Martin, The index was devised by Lawrence B. Martin, graduate dean at the State University of New York graduate dean at the State University of New York at Stony Brook. at Stony Brook.

• It uses faculty publications, citations, awards and It uses faculty publications, citations, awards and grants which it obtains from the web. grants which it obtains from the web.

In 2007, Vanderbilt Pharmacology In 2007, Vanderbilt Pharmacology Ranks # 6 in the CountryRanks # 6 in the Country

• Use of the objective criteria of faculty Use of the objective criteria of faculty publications, citations, awards and grants publications, citations, awards and grants makes clear how strong our faculty are.makes clear how strong our faculty are.

• Main difference this year is # of faculty Main difference this year is # of faculty they found; 100 this year, 45 last yearthey found; 100 this year, 45 last year

Goodbye, we’ll miss Goodbye, we’ll miss you…you…• Pat LevittPat Levitt - Director, Vanderbilt - Director, Vanderbilt

Kennedy Center; will be moving Kennedy Center; will be moving in June 2009 to become the in June 2009 to become the Director of the Zilkha Director of the Zilkha Neurogenetic Institute, Chair of Neurogenetic Institute, Chair of Cell and NeurobiologyCell and Neurobiology

Goodbye, we’ll miss Goodbye, we’ll miss you…you…• Lou DeFeliceLou DeFelice has gone to has gone to

Virginia Commonwealth Virginia Commonwealth University to be Director of University to be Director of Graduate Studies in Physiology Graduate Studies in Physiology and Biophysics and Assistant and Biophysics and Assistant Dean for Graduate EducationDean for Graduate Education

Our ChallengesOur Challenges• Managing fast growthManaging fast growth – puts stress on faculty, – puts stress on faculty,

administration, spaceadministration, space

• Funding in a flat NIH environmentFunding in a flat NIH environment – faculty need – faculty need to be ever more adventuresome about finding to be ever more adventuresome about finding funding; bridge funding is SO appreciated!funding; bridge funding is SO appreciated!

• Economic crisisEconomic crisis affects us all, individually, the affects us all, individually, the department, the institution.department, the institution.

Pharmacology Administrative Pharmacology Administrative HeadcountHeadcount

92111

138

163 164

194214

1908

9

8

14

1111

1111

0

50

100

150

200

250

FY02 FY03 FY04 FY05 FY06 FY07 FY08 FY09

Faculty/Research Staff Count Admin Headcount