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Department of Pharmaceutical Sciences

2016 Annual Report*

* Report is for the calendar year 2016

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Table of Contents

I. Executive Summary 4

II. Who We Are and What We Do: At a Glance 5

Who we are 5

What we do 5

III. 2016 in Review 5

Short Term Goals 5

S1: Increase faculty satisfaction regarding administrative support for research 5

through added personnel, strengthened policies, & advocacy.

S2: Revitalize the graduate curriculum by improving course content, offering 6

development opportunities, and advancing curricular assessment.

S3: Recognize individual differences in strengths, interests, and careers in 8

part by implementing a differential workload policy and by workload

recognition to maximize scholarly, instructional, and service-related goals.

Long-Term Goals 8

L1: Plan for and position the department for increased collaborative research. 8

L2: Offer excellent foundational training in the pharmaceutical sciences to 9

PharmD students by working with Pharmacy Practice, sharing in the

governance and operation of this program, and achieving successful re-

accreditation in 2016.

L3: Position programs to earn acclaim within the university, regionally and 9

nationally as world class training programs for high caliber graduate students,

postdoctoral fellows, and other trainees.

Other Progress 9

IV. Departmental Faculty and Staff 9

Faculty 9

Adjunct Faculty 10

Emeritus Faculty 11

Staff 11

V. Research Personnel in Training 11

Pharmaceutical Sciences Ph.D. Candidates 11

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Ph.D. Candidates Training with PSC Faculty 12

MD / Ph.D. Candidates 12

Pharmaceutical Sciences M.S. Candidates 12

M.S. Candidates Training with PSC Faculty 13

Postdoctoral Scholars 13

Research Assistants / Associates / Scientists 13

PharmD / SURF / Undergraduate / Intern / Volunteer / Others 13

VI. Graduate Degrees Conferred 15

Ph.D. Degrees 15

M.S. Degrees 16

VII. Honors and Awards 16

University 16

College 17

VIII. Professional, Scientific and Other Leadership 17

External to the University 17

Internal (External to College) 17

IX. Scientific Review Panels 18

X. Editorial Boards 20

XI. Grants Awarded 22

Federal Grants 22

Foundation Grants 23

University / College Awards 23

Table of Grants 23

XII. Invited Presentations 25

XIII. Journal Publications 26

XIV. Book Chapters and Books 31

XV. Patents 31

XVI. Abstracts Presented / Published 32

XVII. Departmental Seminars 35

Winter 2016 35

Fall 2016 36

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I. Executive Summary The Department of Pharmaceutical Sciences (PSC) is a

multidisciplinary academic unit formed from pharmacy faculty in 1982 to house the disciplines of medicinal chemistry, pharmacology/toxicology and pharmaceutics. The Department offers MS and Ph.D. degrees in Pharmaceutical Sciences. In addition, our Faculty provide extensive instruction in the professional Doctor of Pharmacy (PharmD) program. In 2016, the Department had 22 exceptional Faculty members and 45 productive graduate students. The Faculty have broad interests, with notable strengths in diabetes, neuroscience, cancer, environmental toxicology and infectious disease research.

Dr. George Corcoran has served as chair and chief administrative officer of the department since 1996. Additional leadership and management are provided by Directors, the faculty, and critical standing committees. Many policies critical to the running of the Department are proscribed by a collectively bargained union contract and the Department is guided by our strategic plan.

In 2016, the Faculty within the Department were highly productive. According to the American Association of Colleges of Pharmacy (AACP) 2014 Research Survey, the Department ranks 37th in NIH funding, with 63% of Faculty are funded. The total number of research publications/abstracts in 2016 from our Department (113) is greater than those of our comparator and aspirational schools. In 2016, the PSC Faculty had a national presence while at the same time embracing the urban mission of the University.

The Department’s graduate program includes degrees offered at both the Ph.D. and MS levels. The Ph.D. program in Pharmaceutical Sciences continues to be highly multi-disciplinary and all students are required to take courses in each of the three disciplines. In 2016, the Department had 23 students in our Ph.D. program, many of whom were funded on a combination of Departmental and Graduate School resources, or through mentor grant support. The Department is unique among similarly ranked institutions in also offering a multi-disciplinary, research-intensive, entry-level MS program. In 2016, there were 22 MS students in the program. These students are consistently highly successful and the academic quality of MS students is comparable to those entering the Ph.D. program.

The Department does not have an undergraduate program. The primary non-graduate teaching is conducted in the PharmD program. Our faculty coordinate courses in the PharmD program and contribute to teaching throughout the curriculum. The Department offers the Summer Undergraduate Research Fellowship (SURF) program, which provides a research- intensive program for highly motivated students. The majority of our SURF students are from Michigan and SURF graduates have been successful in advancing to graduate or professional programs. In 2016, the department hosted 8 SURF students.

Chair:Dr.GeorgeCorcoran

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II. Who We Are and What We Do: At a Glance

Who We Are Faculty: 50 (22 Full-Time, 1 Part-Time, 23 Adjunct, 4 Emeritus). Staff: 3 Graduate Students: 45 (21 Ph.D. Candidates and 2 MD/Ph.D. Candidates, 22 MS Candidates) Postdoctoral Fellows: 12 Research Assistants / Associates / Scientists: 8 PharmD / SURF / Undergraduate / Intern / Volunteer / Other Researchers: 50 What We Do Degrees Granted: 9 (4 Ph.D., 5 M.S.) Honors / Awards: 4 (2 University, 2 College) Professional / Scientific Leadership: 42 (16 External, 26 Internal) Scientific Review Panels: 54 (9 NIH) Editorial Boards: 46 (2 Editors, 3 Associates, 1 Senior, 1 Review, 1 Regional, 1 Honorary, 1

Guest, 20 Board Members) Grants: 13 (8 Federal, 3 Foundation, 2 University/College) Invited Presentations: 25 Publications: 92 (54 Papers, 3 Book Chapters, 3 Patents/Disclosures, 32 Abstracts) Department Seminars: 27

III. 2016 in Review This review attempts to capture essence of the department in 2016 through its programs, activities, accomplishments, progress, culture and life and is organized under the framework of the Department Strategic Plan 2012-2016 short-term and long-term goals. The Chair oversees implementation of the PSC 2012-2016 Strategic Plan by champions and lead stakeholders in all areas, Short Term Goals 1. Increase faculty satisfaction regarding administrative support for research through added personnel, strengthened policies, & advocacy.

In the area of key personnel, the department has been able to maintain administrative

support despite staff turnover. PSC had complete turnover of its staff in 2016, including Administrative Assistant, Secretary, and an experienced Student Assistant. All positions have been filled and high productivity has been maintained.

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A challenge we continue to face is high office workload, and added workload associated with the maturation of four relatively recent faculty additions and their growing laboratories. Competition for department time and other resources expanded at an unprecedented rate in 2016. Major activities included the PharmD ACPE reaccreditation Self-Study assessment and Interim Accreditation Reports, full roll out of the renewed PharmD curriculum, the first-ever NCA HLC Self-Study Evaluation Reports of the Pharmaceutical Sciences PhD and MS programs, and an Academic Program Review for PhD and MS programs. The PharmD and HLC reviews are high stakes and are essential for successful re-accreditation. Other competition for resources included university-wide implementation of online performance assessment systems and a new research grants management system. Advancement of the department research mission has also been hindered due to recurring budget cuts.

The college added an Accounting Specialist, to serve as a new research position focused on researcher post-award support. Dr. Stemmler, who served as the PSC Director of Research, was appointed Associate Chair, our first since 2002. Dr. David Pitts was appointed as the first PSC Director of Curriculum, and Dr. Steven Firestine continues service as the Director of the Graduate Program.

A new department task force was formed to enhance faculty nomination for 8 top university awards, including the Academy of Scholars, the Academy of Scholars Junior Faculty Award, the Board of Governors Faculty Recognition Award, the Career Development Chair Award, multiple Distinguished Faculty Fellowship Awards, the President’s Award for Excellence in Teaching, the Distinguished Graduate Faculty Award, and the Outstanding Graduate Mentor Award. In 2016, Dr. Kowluru received a University Distinguished Professor Award and Dr. Firestine received a University Outstanding Graduate Mentor Award.

2. Revitalize the graduate curriculum by improving course content, offering development opportunities, and advancing curricular assessment.

The faculty approved a new admission policy and a new recruitment plan developed by

the Graduate Program Committee. The class of 2016 PhD candidates included 4 department supported GRAs and 4 PhD candidates on other support. Our first MD/PhD candidate is nearing graduation. The Awards Committee recognized the 2016 George C. Fuller Endowed Scholarship recipient, Mr. Vaibhav Sidarala from the Kowluru lab, and two 2016 Frank O. Taylor Scholarship recipients Ms. Yuran Xie from the Merkel lab and Ms. Shaimaa Yousef from the Iyer lab.

The program completed the fourth year of a redesigned graduate curriculum. Curricular restructuring has increased course rigor but also produced a small increase the number of dismissals. The Doctor of Pharmacy curriculum continued to evolve, including the first offerings of PSC 4115 Pharmaceutics I, and PSC 4125 Introduction to Pharmaceutical Sciences in Fall 2016. Pharmaceutical Sciences played an active role in all areas of the development and roll out of the renewed PharmD curriculum in August 2016. To support and achieve the goal of university reaccreditation by the Higher Learning Commission, and to meet the needs of preparing an extensive Department self-study evaluation in support of a

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2016 Pharmaceutical Sciences Academic Program Review, the Chair created the Pharmaceutical Sciences Assessment Committee guided by Chair Fusao Hirata and Co-Chair Justine Gortney. It prepared materials for a comprehensive self-study report for the Academic Program Reviews, created and mapped learning outcomes for the PhD and the MS curricula and developed tools, metrics and methods for collecting and analyzing data needed to strengthen education outcomes. The committee will review the Assessment Plan yearly and propose plan revisions to the Department Chair in May. The committee will submit an Assessment Report to the Department Chair annually.

The Assessment Committee completed the preparation of the Pharmaceutical Sciences Self-Study 2009-2014 in late 2015 and presented it to the faculty for approval in February 2016. Internal and external evaluation team reports cited strengths including: 1. superb students who are comparable to those in nationally elite programs, 2. outstanding and growing research program driven by a well-funded faculty with productivity that meets or exceeds both comparator and aspirational schools, 3. research-intensive entry level MS program that is unique among Pharmaceutical Sciences programs, 4. outstanding time-to-graduation (one year shorter than WSU average) as well as outstanding retention (25% above WSU and 30% above national average), 5. maintenance of program quality and growth in size despite nearly annual budget cuts, and 6. program leadership and administrative structure. Areas requiring attention or investment were 1. The number of GRAs / faculty member, 2. staff support, 3. numbers of domestic and diverse students and systematic recruiting. 4. some policies and procedures, 5. replacement of retired and departed faculty, and 6. opportunities for student teaching. The department was among the most active in the BEST and ReBuild programs, extending experiences to careers outside academics. Revised formal descriptions, policies and charges were prepared for the Appointment, Awards, Budget, Faculty Search, Promotion, and Tenure committees, and the Biosafety Officer and Associate Chair.

New deadlines were established for forming thesis and dissertation committees, completing written qualifying examinations, completing the prospectus and oral qualifying examinations, and transferring from MS to the PhD program and the Graduate Program Policies and Procedures manual underwent major revision. The 16th Summer Undergraduate Research Fellowship (SURF) program was held.

The department appointed its first Director of Education, Dr. David Pitts in July 2016. His responsibilities of the Director include 1) overseeing planning for improving PhD, MS, SURF, Postdoctoral, PharmD/PhD, MD/PhD, and future curricula, 2) assisting in assessing effectiveness and outcomes of curricula, 3) advising on teaching workload, 5) coordinating faculty mentoring, and 6) serving as education liaison outside the department. He has taken a leadership role in the PharmD Research Scholars track, and preparing materials for the HLC review. A most significant and sad milestone was reached in February of 2016 when Dr. Richard Slaughter passed away after a brief illness. He served at the University of Buffalo before coming to Wayne State 1989 as Chair of Pharmacy Practice. He became Assistant Dean in 2002, and Associate Dean for Pharmacy in 2009. While at the forefront of several

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innovations in the pharmacy profession, he was an incomparable educator, servant and friend to all. 3. Recognize individual differences in strengths, interests, and careers in part by implementing a differential workload policy and by workload recognition to maximize scholarly, instructional, and service-related goals.

Department faculty and the Division of Pharmacy Workload Committee implemented

the new workload policy in 2013. The policy was used in 2013 and 2014, with the understanding that it was provisional and would be revised. Dr. Dutta took a leadership role in advancing the workload committee activities in 2016. Long-Term Goals 1. Plan for and position the department for increased collaborative research.

External funding and internal collaboration among PCS faculty increased substantially

over the past ten years. For the first time two years ago, three PSC faculty earned two or more large federal awards as PIs. In 2016, this number increased to four. The number of research active laboratories reached a historic high at 15, and all 20 department roster positions were filled. Dr. Wormser retired and was appointed Emeritus Professor, and Dr. Merkel went on a leave of absence. Funding in FY 2016 was $2,745,102 of which $2,345,151 was from NIH. Most grant funding to the college comes from highly competitive NIH investigator-initiated R01 awards and other federal agencies to pharmaceutical sciences faculty. In January, Drs. Serrine Lau and Terry Monks joined the department from the University of Arizona, bringing NIH funding. In May 2016, Dr. Jiemei Wang was recruited into the Louis-Ferdinand faculty line from the WSU Center for Molecular Medicine and genetics. She brought a new 5 year NIH R01 and American Heart Association funding.

The department reinvigorated new research partnerships with KCI, Engineering, Infectious Diseases, iBio and companies. A diabetes working group involves Drs. Kowluru, Yi, Chen, Stemmler, Wang, Lau, and Monks. The department approved a revised Research Enhancement Plan in 2016 to increase the number and ratio of supported GRAs.

Our NIH awards are complemented by funding from the Veterans Administration, American Heart and American Diabetes foundations, and competitive internal research programs supported by Wayne State. A top goal of the department and college is to establish one or more multi-investigator grants. Areas that are existing strengths and poised for national competitiveness include diabetes / obesity / metabolic syndrome, neurosciences, cancer, infection, and drug discovery and design. The pharmacy program has taken several steps to advance this goal.

Our partnership with Pune University was advanced significantly by visits by Drs. Iyer and Stemmler to Pune in 2016 where they participated in teaching and symposia, and visited 8 of the top pharmacy programs to describe opportunities within PSC, to plan future faculty

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exchanges, and to identify promising PhD and SURF candidates. A second PhD candidate from Pune was admitted in 2016. 2. Offer excellent foundational training in the pharmaceutical sciences to PharmD students by working with Pharmacy Practice, sharing in the governance and operation of this program, and achieving successful re-accreditation in 2016.

Our faculty play leadership roles on the PharmD Accreditation Steering Committee and

other PharmD committees including chairing the curriculum and co-chairing the admissions committees. The PharmD program was successfully reaccredited in 2016 through 2018 by ACPE. The Department co-hosted a visiting delegation from the Centro Escolar University College of Pharmacy, the Philippines in 2016, with the goal of develop bidirectional teaching and research collaborations. 3. Position programs to earn acclaim within the university, regionally and nationally as world class training programs for high caliber graduate students, postdoctoral fellows, and other trainees.

The PhD program attracts and graduates excellent scientists. Recent PhD graduates

have taken postdoctoral positions in top programs including at Harvard, MIT the Pennington Institute, and MSU. The number of graduate students doubled over the previous two years is expected increase slightly again next year. Further growth by introducing new MS and BS programs is under consideration. This includes admitting Plan B or Plan C MS candidates. Pharmacy worked with the Registrar to create a mechanism for admitted PharmD students to earn a BS in Health Sciences with a concentration in Pharmaceutical Sciences upon completion of their P1 year and accruing at least 120 credit hours of courses work. Other Progress:

Communication: Department faculty meetings remain at a frequency of 5-7 per year to cultivate more interaction, deliberation, and collective decision-making. A significant number of Congratulations email are distributed to make department members aware of the successes of their colleagues.

IV. Departmental Faculty and Staff

Faculty Hanley N. Abramson, Ph.D., Professor Deepak K. Bhalla, Ph.D., Professor and Interim Dean of the College Fei Chen, Ph.D., Professor Randall L. Commissaris, Ph.D., Associate Professor George B. Corcoran, Ph.D., Professor and Chairman

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Aloke K. Dutta, Ph.D., Professor Steven M. Firestine, Ph.D., Professor Fusao Hirata, Ph.D., Professor Arun K. Iyer, Ph.D., Assistant Professor Anjan Kowluru, Ph.D., Professor and Associate Dean for External Scientific Affairs Serrine Lau, Ph.D., Professor and Dean of EACPHS Olivia M. Merkel, Ph.D., Assistant Professor Terrence Monks, Ph.D., Professor and Assistant Vice President of Integrative Biosciences Anna B. Moszczynska, Ph.D., Associate Professor David K. Pitts, Ph.D., Associate Professor Philip L. Pokorski, Ph.D., Assistant Professor (Clinical) Zhihui Qin, Ph.D., Assistant Professor Duska M. Separovic, Ph.D., Associate Professor (Research) Timothy L. Stemmler, Ph.D., Professor, Assoc. Chair of PSC, Asst. Dean of the Grad School Jiemei Wang, Ph.D., Assistant Professor Zhengping Yi, Ph.D., Professor Hani Zaher, Ph.D., Part-Time Instructor Xiangmin Zhang, Ph.D., Assistant Professor (Research)

Adjunct Faculty Jacob V. Aranda, Adjunct Professor, SUNY Downstate, New York Hossam Ashour, Adjunct Assistant Professor, Pharmacy Practice Amit Banerjee, Past Assistant Professor Research David J.P. Bassett, Adjunct Professor, Family Medicine Michael R. Bleavins, Adjunct Associate Professor, MI Technology & Research Institute Kyle Burghardt, Adjunct Assistant Professor, Pharmacy Practice Christine Davie, Adjunct Assistant Professor, Pharmacy Practice Merlin E. Ekstrom, Adjunct Associate Professor, WSU Peter D. Frade, Associate Professor, Fundamental and Applied Sciences Bradford R. Hepler, Adjunct Assistant Professor, Wayne County Office of Medical Examiner Daniel Isenschmid, Adjunct Assistant Professor, NMS Laboratories, Willow Grove, PA. Edward Kerfoot, Adjunct Professor, Occupational and Environmental Health Sciences Paul Kilgore, Adjunct Professor, Pharmacy Practice Ladislau C. Kovari, Adjunct Associate Professor, Biochemistry Robert E. Levine, Adjunct Professor, Wellness and High-Performance Strategies Jing Li, Adjunct Associate Professor, Karmanos Cancer Institute Emily T. Martin, Adjunct Assistant Professor, University of Michigan Howard J. Normile, Adjunct Associate Professor, Health Care Sciences Allen J. Rosenspire, Adjunct Associate Professor, Microbiology and Immunology Michael J. Rybak, Adjunct Professor, Pharmacy Practice Paul M. Stemmer, Associate Professor, Institute of Environmental Health Sciences Bonita G. Taffe, Adjunct Assistant Professor, State of Michigan Bureau of Laboratories

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David M. Thomas, Adjunct Professor, Oakland University William Beaumont School of Medicine

William D. Watt, Adjunct Professor, Occupational and Environmental Health Sciences Emeritus Faculty Martin Barr Raymond J. Dauphinais Janardan B. Nagwekar Henry Wormser Staff Angela Bumphus, Secretary Latoya Rice, Administrative Assistant Dhanashri Pawale, Student Assistant

V. Research Personnel in Training Pharmaceutical Sciences Ph.D. Candidates Alsaab, Hashem: Graduate Research Assistant, Advisor Dr. Arun Iyer Alzharni, Rami: Graduate Research Assistant, Advisor Dr. Arun Iyer Alzhrani, Majed: Graduate Research Assistant, Advisor Dr. Zhengping Yi Bhise, Ketki: Graduate Research Assistant, Advisor Dr Arun. Iyer Batelu, Sharon: Graduate Research Assistant, Advisor Dr. Timothy Stemmler Damacharla, Divyasri: Graduate Research Assistant, Advisor Dr. Zhengping Yi and Anjan Kowluru Elmabruk, Asma: Graduate Research Assistant, Advisor Dr. Aloke Dutta Killinger, Bryan: Graduate Research Assistant, Advisor Dr. Anna Moszczynska Lewis, Brianne: Graduate Student, Advisor Dr. Timothy Stemmler Li, Lingzhi: Graduate Research Assistant, Advisor Dr. Fei Chen Liao, Yi: Graduate Research Assistant, Advisor Dr. Zhihui Qin Lin, Qian: Graduate Research Assistant, Advisor Dr. Steven Firestine Luo, Dan: Graduate Research Assistant, Advisor Dr. Aloke Dutta Nguyen, Huong: Graduate Research Assistant, Advisor Dr. Terrence Monks Qi, Yue: Graduate Research Assistant, Advisor Dr. Zhengping Yi Sarma, Akil: Graduate Research Assistant, Advisor Dr. Anna Moszczynska Sidarala, Vaibhav: Graduate Research Assistant, Advisor Dr. Anjan Kowluru (Graduated in 2016) Wadgaonkar, Priya: Graduate Research Assistant, Advisor Dr. Anjan Kowluru Wu, Kai: Graduate Research Assistant, Advisor Dr. Fei Chen (Graduated in 2016) Xie, Yuran: Graduate Research Assistant, Advisor Dr. Olivia Merkel Zhang, Qian: Graduate Research Assistant, Advisor Dr. Fei Chen

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Ph.D. Candidates Training with PSC Faculty Barupala, Dulmini: NIH Pre-Doctorial Fellow in the Department of Biochemistry, Advisor Dr.

Timothy Stemmler (Defended in 2016) Feldmann, Daniel: Graduate Research Assistant in Cancer Biology, Advisor Dr. Olivia Merkel Jones, Steven: Graduate Research Assistant in Cancer Biology, Advisor Dr. Olivia Merkel Kusowski, April: Graduate Research Assistant in the Department of Biochemistry, Advisor Dr.

Timothy Stemmler Tremoniti, Annette: Ph.D. Candidate in Civil and Environmental Engineering, Co-Advisor Dr. David

Pitts Wang, Wei: Ph.D. Candidate, Public Health, Joint Training with the Wuhan University, Advisor Dr.

Fei Chen MD / Ph.D. Candidates Dzul, Stephen: NIH Pre-Doctorial Fellow in the Department of Biochemistry, Advisor Dr. Timothy

Stemmler (Graduated in 2016) Streeter, Cale: Graduate Research Assistant, Advisor Dr. Steven Firestine Pharmaceutical Sciences M.S. Candidates Alharbi, Majed: Advisor Dr. Zhengping Yi Alla, Lakshmi: Advisor Dr. David Pitts Ashok Kumar, Srinivas: Advisor Dr. Fei Chen Baidwan, Sartaj: Advisor Dr. Anjan Kowluru Gawde, Kaustubh: Advisor Dr. Arun Iyer Li, Ying: Advisor Dr. Olivia Merkel (Graduated in 2016) Luong, Duy: Advisor Dr. Arun Iyer (Graduated in 2016) Monshi, Manahil: Advisor Dr. David Pitts Ou, Siyu: Advisor Dr. Zhihui Qin Patel, Anjali: Advisor Dr. Timothy Stemmler Pawale, Dhanashri: Advisor Dr. Zhengping Yi Ravipati, Pranay: Advisor Dr. Aloke Dutta Shah, Nishit: Advisor Dr. Zhengping Yi (Graduated in 2016) Simon, Matthew: Advisor Dr. Steven Firestine Singh, Nivedita: Advisor Dr. Michael Rybak (Graduated in 2016) Sulaiman, Shukurat: Advisor Dr. Zhengping Yi Taneja, Rimzim: Advisor Dr. Randall Commissaris Tatiparti, Katyayani: Advisor Dr. Arun Iyer Wang, Yihan: Advisor Dr. Jiemei Wang Wang, Zhaoxian: Advisor Dr. Arun Iyer Yousef, Shaimaa: Advisor Dr. Arun Iyer (Graduated in 2016) Yu, Dongyue: Advisor Dr. Anna Moszczynska

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M.S. Candidates Training with PSC Faculty Hipp, Meridith: MS Public Health, Department of Family Medicine & Public Health Sciences,

Advisor Dr. David Pitts Sale, Derek: BS Education, Michigan Technological University, Advisor Dr. Randall Commissaris Postdoctoral Scholars Caruso, Michael: Ph.D., Advisor Dr. Zhengping Yi Chekuri, Anil: Ph.D., Advisor Dr. Anjan Kowluru Chen, Bailing: Ph.D., Advisor Dr. Zhihui Qin Deshmukh, Rahul: Ph.D., Advisor Dr. Arun Iyer Dinda, Bidyut: Advisor Dr. Aloke Dutta Flack, Amanda: Ph.D., Advisor Dr. Anna Moszczynska Gemechu, Jickssa: Ph.D., Advisor Dr. Anna Moszczynska Kersharwani, Prashant: Ph.D., Advisor Dr. Arun Iyer Ma, Danjun: Ph.D., Advisor Dr. Zhengping Yi Mekala, Naveen: Ph.D., Advisor Dr. Anjan Kowluru Poudel, Anil: Ph.D., Advisor Dr. Anjan Kowluru Thakur, Chitra: Ph.D., Advisor Dr. Fei Chen Yedlapudi, Deepthi: Advisor Dr. Aloke Dutta Research Assistants / Associates / Scientists Das, Banibrata: Ph.D., Research Associate, Supervisor Dr. Aloke Dutta Govindarajan, Barani: MS, Research Scientist, Supervisor Dr. Olivia Merkel Kandegedara, Ashoka: Ph.D., Research Scientist, Supervisor Dr. Timothy Stemmler Lu, Yongju: MS, Research Assistant, Supervisor Dr. Fei Chen Sharma, Shiv: Ph.D. Research Scientist, Supervisor Dr. Steven Firestine Thompson, Lindsey: BS, Laboratory Director, Supervisor Dr. Timothy Stemmler Veluthakal, Rajakrishnan: Ph.D., Research Scientist, Supervisor Dr. Anjan Kowluru Xu, Liping: Ph.D., Research Technician, Supervisor Dr. Aloke Dutta PharmD / SURF / Undergraduate / Intern / Volunteer / Other Researchers PharmD Althabte, Anas Jamal: Advisor Dr. Fei Chen Al-Ameen, Rashad: Advisor, Dr. Randall Commissaris Berak, Bradley: Advisor, Dr. Randall Commissaris Bint, Brian: Advisor, Dr. Randall Commissaris Calme, Griffin Robert: Advisor Dr. Zhengping Yi DeLor, Jeremy: Advisor Dr. Duska Separovic Haddad, Justin: Dr. Arun Iyer Hana, Rand: Dr. Arun Iyer Hanna, Andrew: Dr. Arun Iyer

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Ho, Dung: Advisor, Dr. Randall Commissaris Hu, Alice: Advisor Dr. Zhengping Yi Isert, Lorenz: German Pharmacy Resident, Advisor Dr. Olivia Merkel Khalil, Ali: Dr. Arun Iyer Koka, Arjol: Advisor Dr. David Pitts Kraetzig Donini, Eduardo: Advisor Dr. David Pitts Makki, Helena: Advisor, Dr. Randall Commissaris Matti, Faddy Yousif:Advisor Dr. Fei ChenMikhail, Sandra:Advisor Dr. Fei Chen Nahle, Bilal: Advisor Dr. David Pitts Odisho, Nicole: Advisor Dr. Zhengping Yi Pasovic, Amir: Advisor Dr. David Pitts Patel, Jessica: Advisor Dr. Anna Moszczynska Pavlik, Lauren: Advisor Dr. Zhengping Yi Reslan, Ahmad: Advisor Dr. David Pitts Salameh, Mariam: Advisor Dr. Randall Commissaris Waldron, Sylvia: Advisor Dr. Anna Moszczynska SURF (Summer Undergraduate Research Fellow) Ferger, Kelly: Advisor Dr. Timothy. Stemmler Reid, Niyla: Advisor Dr. David Pitts Rhinesmith, Tyler: Advisor Dr. Anna Moszczynska Santilli, Nicollete: Advisor Dr. Terry Monks Sorenson, Katie: Advisor Dr. Zhihui Qin Varghese, Danny: Advisor Dr. Serrine Lau Wikens, Jenny: Advisor Dr. Arun Iyer Zhu, Yilin: Advisor Dr. Fei Chen Undergraduate Antonczak, Luke: Undergraduate Researcher, Wayne State University, Supervisor Dr. Timothy

Stemmler Belavek, Kayla: Undergraduate Researcher, Advisor Dr. Olivia Merkel Malone, Ki-Jana: Undergraduate Researcher, Wayne State University, Supervisor Dr. Randall

Commissaris Mohommad, Mohommad B: Undergraduate Researcher, Wayne State University, Supervisor, Dr.

Randall Commissaris Nwamba, Chima: Undergraduate Researcher, Wayne State University, Supervisor Dr. Timothy

Stemmler Parker, Jasmine: Undergraduate Researcher, Wayne State University, Supervisor Dr. David Pitts Reid, Niyla: Undergraduate Researcher, Wayne State University, Supervisor Dr. David Pitts Rhinesmith, Tyler:Undergraduate Researcher, Wayne State University, Supervisor Dr. Anna

Moszczynska Intern Baier, Sabrina: German Pharmacy Summer Intern, Advisor Dr.Olivia Merkel

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Gerpheide, Anna-Lena: German Pharmacy Summer Intern, Advisor Dr.Olivia Merkel Nofar, Thomas: Intern, Advisor Dr. Fei Chen Zimmermann, Christop: German Pharmacy Summer Intern, Advisor Dr.Olivia Merkel Volunteer Denton, Sara: Volunteer, Supervisor Dr. Anna Moszczynska Hauseman, Andrea: Volunteer, Supervisor Dr. Anna Moszczynska Wang, Shu: BS, Volunteer, Advisor Dr. Olivia Merkel Other Researchers Ahmed, Aisha: Port Hurn Norther High School, Supervisor Dr. David Pitts Ammar, Amina: Research Assistant, University of Michigan Dearborn, Supervisor Dr. Randall

Commissaris Banchette, Ashley: Student Research Assistant, WSU Honors College, Supervisor Dr. Randall

Commissaris Sitto, Brenda: Supervisor Dr. Zhengping Yi Willis, Rebecca: Supervisor Dr. Zhengping Yi

VI. Graduate Degrees Conferred in 2016

PhD Conferred

Dr. Dulmini Barupala: Advisor: Dr. Timothy Stemmler Thesis Title: Characterization of the Yeast Cysteine Desulfurase Complex within Mitochondrial Fe-S Cluster Biogenesis. Current: Director Med-Direct Program, Wayne State University, Detroit, MI Dr. Stephen Dzul: Advisor: Dr. Timothy Stemmler Thesis Title: Insights into De Novo Fe-S Cluster Biogenesis via the Eukaryotic Fe-S Cluster Pathway (ISC) In Vitro. Current: Third Year Medical Student at WSU in the MD/PhD Program Dr. Vaibhav Sidarala: Advisor: Dr. Anjan Kowluru Thesis Title: Mechanisms of pancreatic beta cell dysfunction in diabetes. Current: Post-Doctoral Fellow, Diabetes Center, University of Michigan, Ann Arbor, MI Dr. Kai Wu: Advisor: Dr. Fei Chen Thesis Title: Exploration of cancer proliferative signaling in chemotherapy drug resistance and mdig-induced tumorigenesis. Current: Postdoctoral Fellow, University of Michigan, Ann Arbor, MI

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MS Conferred

Ying Li: Advisor: Dr. Olivia Merkel Thesis Title: Folate receptor targeted three-layered micelles and hydrogels for gene delivery to activated macrophages. Current: Duy Luong: Advisor: Dr. Arun Iyer Thesis Title: Denrimer-coated iron oxide theranostic nanoparticles for cancer imaging and therapy. Current: Volunteer Research Assistant in U-BiND Systems Lab; Will be joining University of Michigan, Ann Arbor, MI for PhD in Fall 2017 Siyu Ou: Advisor: Dr. Zhihui Qin Thesis Title: Design and synthesis of enzalutamide-isothiocyanate hybrid drug as anti-prostate cancer agents. Current: Research Assistant in Dr. Zhihui Qin's lab, Department of Pharmaceutical Sciences, WSU, MI. Nivedita Singh: Advisor: Dr. Michael Rybak Thesis Title: Impact of cefazolin co-administration with vancomycin to reduce development of vancomycin intermediate staphylococcus aureus. Current: Research Assistant, Anti-Infective Research Laboratory, Department of Pharmacy Practice, WSU Shaimaa Yousef: Advisor: Dr. Arun Iyer Thesis Title: Targeted delivery of Nrf2 siRNA using modular polymeric micellar nanodelivery system for efficient target gene knockdown in hepatocellular carcinoma. Current: Research and Teaching Assistant, Faculty of Pharmacy, Cairo University, Egypt. VII. Honors and Awards

University

Dutta, Aloke: Outstanding Graduate Mentor, Wayne State University. Firestine, Steven: Faculty Recognition Award in Pharmaceutical Sciences, Wayne State

University

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College

Zaher, Hani: Teacher of the Year award, WSU College of Pharmacy 2016. Pitts, David: Professor of the Year award, WSU College of Pharmacy, Class of 2018.

VIII. Professional, Scientific and Other Leadership External to University

Corcoran, George: Workshop Organizer and Chair, Cannabis in the Courtroom, 55th Annual

Meeting of the Society of Toxicology, New Orleans, LA Corcoran, George: Member, National Toxicology Program Board of Scientific Counselors Corcoran, George: Board Member Representative, National Toxicology Program Report on

Carcinogens: Cobalt Iyer, Arun: Member, Molecular Therapeutics Program, Karmanos Cancer Institute, WSU

School of Medicine. Iyer, Arun: Member, WSU-Pune University, Research Collaboration and Student Review

Panel. Iyer, Arun: Member, PhD Thesis committee, NIRMA University, Ahmedabad, India. Kowluru, Anjan: Member, Selection Committee for SFRBM 2016 Lifetime Achievement Awards Kowluru, Anjan: Member, Selection Committee for SFRBM 2016 Fellows Selection Committee Lau, Serrine: Member, Executive Committee, HESI Lau, Serrine: Treasurer, HESI. Lau, Serrine: Toxicology Forum Program Planning Committee Lau, Serrine: Chair, Symposium “Fortuitous Protein Modification in Disease Pathogenesis and

Treatment”, Division of Toxicology, ASPET, San Diego April 5, 2016. Lau, Serrine: Member, International Life Sciences Institute (ILSI) Board of Trustees. Lau, Serrine: Vice-President, Board of Trustees, HESI. Monks, Terrence: Professor and Chair, Department of Pharmacology and Toxicology, College

of Pharmacy, University of Arizona Health Sciences Center, Tucson, AZ. Monks, Terrence: Director, ROS and Disease Prevention Research Core, Southwest

Environmental Health Sciences Center. Monks, Terrence: Associate Dean for Research & Graduate Studies, College of Pharmacy,

University of Arizona Health Sciences Center, Tucson, AZ. Monks, Terrence: Chairman, Special Emphasis Panel (ZRG1 DKUS C 54) evaluating RO1 &

R21 applications responding to PAR-14-203/204 “Environmental Contributors to Autism Spectrum Disorders”

Internal (External to College)

Bhalla, Deepak: Joint appointments in Karmanos Cancer Institute, Wayne State University,

Detroit, MI

18

Commissaris, Randall: Associate Professor, Psychiatry and Behavioral Neurosciences (Adjunct), School of Medicine, Wayne State University.

Corcoran, George: Co-Chair, WSU Chairs and Directors Development Committee. Corcoran, George: Member, Technology Transfer and Commercialization Review Committee Corcoran, George: Member, OVPR Research Enhancement Program Review Panel Corcoran, George: Member, Postdoctoral Office Advisory Board Corcoran, George: Academic Departments and Programs Review Committee Corcoran, George: Chairs and Directors: Higher Learning Commission Accreditation /

Educational Assessment (Co-Org) Corcoran, George: Chairs and Directors: Performance Evaluation (Co-Organizer) Corcoran, George: Chairs and Directors: Team Scholarship (Co-Organizer) Hirata, Fusao: Chair, WSU Radiation Safety and Radioisotope Committee. Hirata, Fusao: Member, University Fellowship Review Committee Kowluru, Anjan: Adjunct Professor, Institute for Environmental Health Sciences [IEHS] Kowluru, Anjan: Professor of Internal Medicine, Division of Endocrinology and Metabolism,

Wayne State School of Medicine. Kowluru, Anjan: Member, Diabetes and Obesity Team Science [DOTS] Program Kowluru, Anjan: Acting ACOS-Research and Development, JDD VA Medical Center Kowluru, Anjan: Research Integrity Officer, JDD VA Medical Center Kowluru, Anjan: Secretary/Treasurer [acting], Metropolitan Detroit Research and Education

Foundation [MDREF], John D. Dingell VA Medical Center, Detroit Kowluru, Anjan: Deputy ACOS-Research Kowluru, Anjan: Member, Outstanding Graduate Mentor Award and the Distinguished

Graduate Faculty Award Selection Committee, Graduate School, Wayne State University Kowluru, Anjan: Judge, Graduate and Post-Doctoral Research Symposium, Wayne State

University Pitts, David: Co-Director, Urban Watershed Environmental Research Group (UWERG). Pitts, David: Member, Healthy Urban Waters (HUW) Advisory Board Stemmler, Timothy: Brookhaven National Laboratory/Case Western Reserve P30 Advisory

Committee Stemmler, Timothy: Faculty Mentoring Committee, Department of Chemistry, College of

Charleston, Charleston, SC Stemmler, Timothy: Asst. Dean of Grad School, Assoc. Dir of Postdoctoral Studies Stemmler, Timothy: Director, WSU Graduate Admissions Director Search Committee.

IX. Scientific Review Panels Bhalla, Deepak: Member, National Research Council Committee on Toxicology Chen, Fei: External Assessor of Research Grants Council of Hong Kong Chen, Fei: Reviewer, the Israel Science Foundation Chen, Fei: Reviewer, National Medical Research Council of Singapore

19

Chen, Fei: Reviewer, Italian Ministry of Health in association with NIH Chen, Fei: Member, Data and Safety Monitoring Board, School of Medicine, Wayne State

University Chen, Fei: Ad hoc, NIH Cancer Genetics Study Section Commissaris, Randall: Member Addiction Research Institute of Michigan. Commissaris, Randall: American Society for Pharmacology and Therapeutics (ASPET) Dutta, Aloke: Ad hoc reviewer of DDNS “Drug Discovery for the Nervous System” Dutta, Aloke: Ad hoc reviewer Molecular Probes, ZRG1 MDCN-C (58) Firestine, Steven: Grant Reviewer, National Institutes of Health, ZRG1 IDM-X(10)B. Hirata, Fusao: Member, National Foundation of Sciences (USA) Scientific Council. Hirata, Fusao: National Institutes of Health, Ad hoc Reviewer. Hirata, Fusao: Member, North Atlantic Treaty Organization Scientific Council. Hirata, Fusao: Member, Neurological Sciences, NIH Study Section 1988 Hirata, Fusao: Member, Veterans Administration, Medical Sciences Iyer, Arun: Grant Reviewer, KCI Small Molecule Drug Discovery and Development, Karmanos

Cancer Institute, Detroit, MI Iyer, Arun: Reviewer, EACPHS Annual Research Forum, Wayne State University, Detroit, MI Iyer, Arun: Grant Reviewer, Faculty Research Awards Program (FRAP), EACPHS, Wayne

State University, Detroit, MI Iyer, Arun: Grant Reviewer, National Science Centre in Poland, Government of Poland,

Karakov, Poland. Iyer, Arun: Member, American Association of Pharmaceutical Scientists (AAPS) Iyer, Arun: Member, American Chemical Society (ACS) Iyer, Arun: Member, American Association of Colleges of Pharmacy (AACP) Iyer, Arun: Member, Society of Nuclear Medicine (SNM) Iyer, Arun: Member, The Controlled Release Society (CRS) Iyer, Arun: Member, Japanese Society of Drug Delivery System (DDS) Iyer, Arun: Member, Society of Polymer Science, Japan (SPSJ) Iyer, Arun: Member, Society of Polymer Science, India (SPSI) Iyer, Arun: Member, Society of Molecular Imprinting, Sweden (SMI) Kowluru, Anjan: Member, Center for Urban Resources to Environmental Stressors [CURES],

Wayne State University Kowluru, Anjan: Member, Advisory Committee for the Annual Research Day Symposium on

“Precision translational medicine for improving veteran’s health care” held at Harry S. Truman Veterans Hospital, Columbia in May, 2016

Kowluru, Anjan: Voting Member, Detroit Research and Development Committee Kowluru, Anjan: Voting Member, Subcommittee on Research Safety Kowluru, Anjan: Voting Member, Institutional Biosafety Committee Kowluru, Anjan: Member, Scientist Promotion Review Panel Kowluru, Anjan: Recognized Reviewer, Biochemical Pharmacology Kowluru, Anjan: Member, Department of VA VISN 11 Research Council [Detroit, Ann Arbor

and Indianapolis VA Medical Centers]

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Kowluru, Anjan: Board Member, Metropolitan Detroit Research and Education Foundation [MDREF], John D. Dingell VA Medical Center, Detroit

Merkel, Olivia: Reviewer, National Institutes of Health Innovative Research in Cancer Nanotechnology (IRCN).

Merkel, Olivia: Reviewer, Oak Ridge Associated Universities (ORAU), NASA Postdoctoral Program (NPP).

Merkel, Olivia: Reviewer, Oak Ridge Associated Universities (ORAU), Pennsylvania Department of Health (PADOH).

Merkel, Olivia: Reviewer, Kentucky Science & Engineering Foundation. Moszczynska, Anna: Grant application reviewer, National Institutes of Health (NIH):

Neurobiology of Motivated Behavior (NMB) Study Section. Moszczynska, Anna: Ad hoc grant application reviewer, National Institutes of Health (NIH):

K99/R01 Pathway to Independence Award panel. Moszczynska, Anna: Ad hoc grant application reviewer, Belgian Research Foundation

Flanders (FWO). Moszczynska, Anna: Ad hoc grant application reviewer for the Czech Science Foundation Stemmler, Timothy: Grant Reviewer, French National Research Agency (ANR) Stemmler, Timothy: Grant Reviewer, German Research Foundation (DFG) Stemmler, Timothy: Grant Reviewer, NIH – ZRG1 BCMB-D (02)M Special Emphasis Panel Stemmler, Timothy: Grant Reviewer, NSF – Biomolecules Study Section (Ad Hoc). Stemmler, Timothy: Grant Reviewer, Friedreich’s Ataxia Research Alliance (Ad Hoc). Stemmler, Timothy: Grant Reviewer, Reviewer, Petroleum Research Fund (Ad Hoc). Stemmler, Timothy: Grant Reviewer, Stanford Synchrotron Radiation Laboratory. Yi, Zhengping: Member, American Diabetes Association's Research Grant Review Committee. Yi, Zhengping: Member, NIH/NIDDK, Clinical and integrative Diabetes and Obesity (CIDO)

Study Section.

X. Editorial Boards Bhalla, Deepak: Editorial Board Member, Journal of Toxicology and Environmental Health Bhalla, Deepak: Associate Editor, Inhalation Toxicology Chen, Fei: Senior Editorial Board Member, American Journal of Cancer Research. Chen, Fei: Editorial Board Member, Journal of Cancer Therapeutics and Research. Chen, Fei: Editorial board member, Occupational Diseases and Environmental Medicine. Chen, Fei: Editorial board member, Journal of Hepatocellular Carcinoma. Chen, Fei: Editorial Board Member, Annals of Cancer Research. Chen, Fei: Editorial Board member, International Journal of Respiratory and Pulmonary

Medicine. Chen, Fei: Editorial Board Member, Toxicology and Applied Pharmacology. Corcoran, George: Editor, Journal of Pharmaceutical Sciences and Pharmacology. Corcoran, George: Editor, MO Journal Toxicology.

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Corcoran, George: Associate Editor, Toxicology and Applied Pharmacology. Corcoran, George: Guest Editor, Toxicology and Applied Pharmacology Dutta, Aloke: Honorary Editorial Board Member, Research and Reports in Medicinal Chemistry. Dutta, Aloke: Editorial Board Member, Current Medicinal Chemistry-Central Nervous System. Dutta, Aloke: Editorial Board Member, The Open Bioactive Compounds Journal. Dutta, Aloke: Editorial Board Member, Pharmaceutics. Dutta, Aloke: Editorial Board Member, Journal of Drug Discovery, Development and Delivery. Dutta, Aloke: Editorial Board Member, Neurotransmitter. Firestine, Steven: Editorial Board Member, ACS Combinatorial Science. Hirata, Fusao: Editorial Board Member, DNA and Biology. Hirata, Fusao: Editorial Board Member, Journal of System Biology. Hirata, Fusao: Editorial Board Member, International Journal of Clinical Pharmacology and

Toxicology. Hirata, Fusao: Editorial Board Member, SOJ Pharmacy & Pharmaceutical Sciences. Hirata, Fusao: Editorial Board Member, Versita in Medicine, Pharmacy and Public Health. Hirata, Fusao: Editorial Board Member, Austin Journal of Pharmacology and Therapeutics. Hirata, Fusao: Editorial Board Member, J. Pharmacology Toxicology Research. Iyer, Arun: Editorial Board Member, Annals of Pharmacology and Pharmaceutics Journal. Iyer, Arun: Editorial Board Member, The Scientific Pages of Pancreatic Cancer Journal. Iyer, Arun: Editorial Board Member, The Scientific Pages of Pharmacology and

Pharmaceutical Science Journal. Iyer, Arun: Editorial Board Member, The Scientific Pages of Nanotechnology. Kowluru, Anjan: Editorial Board Member, Recent Patents on Endocrine, Metabolic and

Immune Drug Discovery. Kowluru, Anjan: Editorial Board Member, Biochemical Pharmacology. Kowluru, Anjan: Editorial Board Member, Metabolic & Functional Research on Diabetes. Kowluru, Anjan: Editorial Board Member, Islets. Kowluru, Anjan: Editorial Board Member, JOP- Journal of Pancreas. Kowluru, Anjan: Editorial Board Member, Journal of Membrane Science and Technology. Kowluru, Anjan: Editorial Board Member, Journal of Diabetes and Metabolism. Kowluru, Anjan: Editorial Board Member, OA Diabetes [London]. Kowluru, Anjan: Review Editor, Frontiers in Diabetes. Kowluru, Anjan: Editorial Board Member, International Journal of Diabetology and Vascular

Disease Research. Kowluru, Anjan: Regional Editor, Recent Patents on Endocrine, Metabolic and Immune Drug

Discovery. Merkel, Olivia: Editorial Board Member, Drug Delivery Letters. Merkel, Olivia: Editorial Board Member, European Journal of Pharmaceutics and

Biopharmaceutics. Monks, Terrence: Editorial Board Member, Chemical-Biological Interactions. Monks, Terrence: Associate Editor - Toxicology & Applied Pharmacology. Moszczynska, Anna: Editorial board member, Scientific Reports (Nature Publishing Group)

22

Yi, Zhengping: Editorial Board Member, Journal of Proteomics & Bioinformatics. Yi, Zhengping: Editorial Board Member, Journal of Data Mining in Genomics & Proteomics. Yi, Zhengping: Editorial Board Member, International Journal of Clinical Pharmacology and

Toxicology.

XI. Grants Awarded (Summarized in Table 1)

Federal Chen, Fei: NIH R01 ES020137 Titled “MicroRNA-190 and Oxidative Stress in Arsenic

Carcinogenesis” Chen, Fei (Kowluru Co-I): NIH RO1DK110314 Titled “Proinsulin ER Export and Beta-Cell

Homeostasis in Diabetes” Chen, Fei (Kowluru Co-I): NIH R56DK102039 Titled “Proinsulin ER Export and Beta-Cell

Homeostasis in Diabetes” Kowluru, Anjan: Department of VA MERIT Review 1O1BX00281 Titled “Novel Regulators of

Islet Beta-Cell Function in Health and Diabetes”. Kowluru, Anjan: Department of VA Senior Research Career Scientist Award 13S-RCS-006 Kowluru, Anjan: NIH RO1EY022230 titled “NADPH Oxidase, Mitochondrial Dysfunction and

Diabetic Retinopathy”. Kowluru, Anjan: NIH RO1EY022230 [supplemental award] titled “NADPH Oxidase,

Mitochondrial Dysfunction and Diabetic Retinopathy”. Kowluru, Anjan: Shared Equipment [ShEEP] Award from VA to purchaseVevo 3100

Ultrasound instrument. Kowluru, Anjan: VA Merit Award [101BX002019] Titled “Diabetes: ERK5 and Vascular

Inflammation” Moszczynska, Anna: NIH R01DA034783 Titled “Proteasome and Parkin as Drug Targets

Against Methamphetamine Toxicity” Pitts, David: NSF-FSML 1624761, Co-PI, “HEART Field Station Improvements for Urban

Watershed Research and Education” Pitts, David: NIH R21- ES027199, Co-PI, Project Titled: “Rapid response to contaminants in

Flint drinking water” Stemmler, Timothy: NIH R01 GM107542 Titled “Mitochondria Cytoplasm Interaction for

Cytosolic Fe-S Cluster Assembly” Stemmler, Timothy: NIH R01 DK068139 Titled “Structural Insights into the Function of

Frataxin” Stemmler, Timothy: NIH F30 DK101230 Titled “Characterizing Isu Scaffolding Protein and ISC

Multiprotein Complex Structure and Function In Vitro” Wang, Jiemei: NIH DK109036 Titled “Role of Inositol requiring enzyme 1 in regulating

angiogenesis for diabetic wound repair” Yi, Zhengping (Kowluru Co-I): NIH R01DK081750 Titled “Human Skeletal Muscle Proteome

and Phosphoproteome in Obesity and Type 2 Diabetes”

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Yi, Zhengping (Kowluru Co-I): NIH R01DK107666 Titled “Serine/threonine Protein Phosphatase 1 in Insulin resistance and Type 2 Diabetes”

Foundation Wang, Jiemei: American Heart Association 13SDG16930098 Titled “MicroRNA regulation of

endothelial progenitor cell apoptosis in diabetic wound healing” Yi, Zhengping: American Diabetes Association 300385387 Titled “Protection against insulin

resistance in obesity” Zhang, Xiangmin: MDRC Titled “Recombinant attenuated bacteria as drug to initiate insulin

synthesis in vivo”

University/College Dutta, Aloke: New York University Titled “Biogenic Amine Transporters: Mechanisms of Ligand Interactions” Firestine, Steve: University of Las Vegas Titled “Prophylaxis of Clostridium difficile infection” Table 1: PSC Grant Detailed Information (*Total Award)

PSC Faculty

Sponsor Grant Title Start Date End Date Project Amount*

Chen, Fei

NIH MicroRNA-190 and Oxidative Stress in

Arsenic Carcinogenesis

9/1/12 5/31/17 $2,048,592

Chen, Fei

NIH Proinsulin ER Export and Beta-Cell Homeostasis in

Diabetes

9/1/16 8/31/21 $1,746,357

Chen, Fei

NIH Proinsulin ER Export and Beta-Cell Homeostasis in

Diabetes

9/15/15 8/31/16 $152,958

Dutta, Aloke

NYU Biogenic Amine Transporters:

Mechanisms of Ligand Interactions

4/1/16 3/31/17 $20,000

Firestine, Steve

UNLV Prophylaxis of Clostridium difficile infection

12/1/14 11/30/19 $1,308,864

Kowluru Anjan

VA Novel Regulators of Islet Beta-Cell Function in Health and Diabetes

7/1/15 6/30/19 $650,000

Kowluru Anjan

VA Senior Research Career Scientist Award

9/1/13 8/31/20 $1,320,000

Kowluru Anjan

NIH NADP Oxidase, Mitochondrial Dysfunction and Diabetic Retinopathy

4/1/12 3/31/18 $1,520,000

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Kowluru Anjan

NIH NADP Oxidase, Mitochondrial Dysfunction and Diabetic Retinopathy

[Administrative Supplement]

4/1/12 3/31/18 $50,500

Kowluru Anjan [Co-I]

VA-Merit Diabetes:ERK5 and Vascular Inflammation

10/1/14 9/30/18 $1,113,000

Kowluru Anjan [Co-I]

VA-ShEEP Vevo 3100 Ultrasound Instrument

2016 Not applicable

$556,000

Moszczynska, Anna

NIH Proteasome and Parkin as Drug Targets Against

Methamphetamine Toxicity

9/15/13 5/31/18 $2,029,580

Pitts, David

NIH Rapid response to contaminants in Flint

drinking water

4/1/16 3/31/18 $422,110

Pitts, David

NSF HEART Field Station Improvements for Urban

Watershed Research and Education

8/1/16 1/31/18 $251,996

Stemmler, Timothy

NIH Structural Insights into the Function of Frataxin

8/1/11 7/31/16 $1,995,386

Stemmler, Timothy

NIH Mitochondria Cytoplasm Interaction for Cytosolic Fe-S Cluster Assembly

7/1/14 4/30/17 $79,637

Stemmler, Timothy

NIH Characterizing Isu Scaffolding Protein and ISC Complex Structure and Function In Vitro

8/1/14 7/31/19 $281,534

Wang, Jiemei

NIH Role of Inositol requiring enzyme 1 in regulating

angiogenesis for diabetic wound repair

3/1/16 2/28/21 $1,702,343

Wang, Jiemei

AHA MicroRNA regulation of endothelial progenitor cell

apoptosis in diabetic wound healing

7/1/13 6/30/17 $231,000

Yi, Zhengping

NIH Serine/threonine Protein Phosphatase 1 in Insulin resistance and Type 2

Diabetes

9/25/15 8/31/20 $2,583,325

Yi, Zhengping

NIH Human Skeletal Muscle Proteome and

Phosphoproteome in Obesity and Type 2

Diabetes

8/1/14 4/30/18 $1,349,133

25

Yi, Zhengping

ADA Protection against insulin resistance in obesity

1/1/16 12/31/18 $148,158

Zhang, Xiamging

NIH Recombinant attenuated bacteria as drug to initiate insulin synthesis in vivo

12/1/16 11/30/17 $36,000

XII. Invited Presentations Chen, Fei: “Mdig and cancer, 20 years of mining and digging.” Department of Biomedical

Sciences, City University of Hong Kong Chen, Fei: “Metabolic reprogramming of the arsenic-induced cancer stem cells.” 9th Metal

Toxicology & Carcinogenesis, Lexington, Kentucky Corcoran, George: “Cannabis in the Courtroom.” Itinerary Planner, 55th Annual Meeting of the

Society of Toxicology, New Orleans, LA Dutta, Aloke: “Implication of multifunctional d3 preferring agonists as therapeutic agents in

Parkinson’s disease”, 33rd Camerino-Cyprus Symposium, Camerino, Italy Iyer, Arun: “Hyaluronic Acid Engineered Nanomicelles for Targeting CD44 Overexpressing

Cancers.” Polymer Science and Engineering Division, National Chemical Laboratory, Pune, India.

Iyer, Arun: “Hyaluronic Acid Engineered Nanomicelles loaded with 3,4-difluorobenzylidine Curcumin for Targeted Pancreatic Cancer Therapy.” 3rd International Conference on Herbal and Synthetic Drug Studies. Allana College of Pharmacy, University of Pune, Pune, India.

Iyer, Arun: “Graduate Studies and Higher Education Opportunities in the United States and WSU.” Sinhgad college of Pharmacy, University of Pune, Pune, India.

Iyer, Arun: “Graduate Studies and Higher Education Opportunities in the United States and WSU.” Allana College of Pharmacy, University of Pune, Pune, India.

Merkel, Olivia: “Smart dosage forms for siRNA delivery as therapy of inflammatory diseases.” Department of Clinical Pharmacy, Medical University of Vienna

Merkel, Olivia: “Smart dosage forms for targeted siRNA delivery.” Boehringer-Ingelheim, Biberach,

Merkel, Olivia: “Smart dosage forms for targeted siRNA delivery.” Nanosystems Initiative Munich, Munich

Merkel, Olivia: “New Approaches in Current Asthma Therapy.” German Pharmaceutical Society (DPhG), LMU Munich

Merkel, Olivia: “In-situ forming gel devices as local depot therapeutic for Rheumatoid Arthritis.” 14th European Symposium on Controlled Drug Delivery, Egmond aan Zee, The Netherlands

Merkel, Olivia: “Targeted nanoparticles for siRNA delivery” Winter School, Nanosystems Initiative Munich

Merkel, Olivia: “Smart dosage forms for siRNA delivery as therapy of inflammatory diseases.” Department of Biochemistry, WSU

Moszczynska, Anna: 9th Symposium on Neuroprotection and Neurorepair. Leipzig, Germany

26

Stemmler, Timothy: “Monitoring Biomolecules that Direct Mitochondrial Fe Homeostasis.” Department of Chemistry, University of Michigan, Ann Arbor, MI

Stemmler, Timothy: “Molecular Factors that Drive Mitochondrial Fe-S Cluster Biosynthesis.” 3rd International Conference on Herbal and Synthetic Drug Studies, Pune, India

Stemmler, Timothy: “Molecular factors that drive mitochondrial Fe-S cluster biosynthesis.” Metals in Biology Gordon Conference, Ventura, CA

Stemmler, Timothy: “Molecular factors that drive mitochondrial Fe-S cluster biosynthesis.” Chemistry Department, Wayne State University, Detroit, MI

Stemmler, Timothy: “Fe-S Clusters in Gene Regulation.” American Chemical Society National Meeting, San Diego, CA

Stemmler, Timothy: “Molecular factors that drive mitochondrial Fe-S cluster biosynthesis.” American Chemical Society National Meeting, San Diego, CA

Stemmler, Timothy: “Molecular factors that drive mitochondrial Fe-S cluster biosynthesis.” FASEB Meeting, Big Sky, MT

Stemmler, Timothy: “Molecular factors that drive mitochondrial Fe-S cluster biosynthesis.” Chemistry Department, Nanjing University, China

Stemmler, Timothy: “Molecular factors that drive mitochondrial Fe-S cluster biosynthesis.” Chemistry Department, Institute for Environmental Science, Chinese National Academy, Xiamen, China

XIII. Journal Publications Abramson, H.N.: Kinase Inhibitors as Potential Agents in the Treatment of Multiple Myeloma.

Oncotarget; 7:81926-68. doi: 10.18632/oncotarget.10745, 2016. Li, L., Chen, F. Oxidative stress, miRNAs and cancer stem cells in arsenic carcinogenesis and

prevention. Current Pharmacology Reports, 2:57-63, doi:10.1007/s40495-016-0049-y, 2016. Ammar, A., Blanchette, A., Sale, D., LaForest, D., Palumbo, T., Swift, A., Head, D. and

Commissaris, R. Texting, Drugs and Driving: A “Triple Threat” to Driving Safety. Journal of Ergonomics, 6:154. doi:10.4172/2165-7556.1000154, 2016.

Zhen, J., Antonio, T., Dutta, AK., Salley, D., Reith, MEA., Efficacy of hybrid tetrahydrobenzo[d]thiazole based aryl piperazines D-264 and D-301at D2 and D3 receptors. Neurochemical Research;41(1-2):328-39, doi: 10.1007/s11064-015-1808-6, 2016

Dholkawala, F., Voshavar, C., Dutta, AK. Synthesis and Characterization of Brain Penetrant Prodrug of Neuroprotective D-264: Potential Therapeutic Application in the Treatment of Parkinson’s Disease. Journal of Pharmaceutics and Biopharmaceutics. 103, 62–70, doi: 10.1016/j.ejpb.2016.03.017.2016.

Yedlapudi, D., Joshi, G., Luo, D., Todi, S., Dutta, AK. Inhibition of alpha-synuclein aggregation by multifunctional dopamine agonists assessed by a novel in vitro assay and an in vivo Drosophila synucleinopathy model. Scientific Reports 6, Article number: 38510, doi:10.1038/srep38510, 2016.

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Luo, D., Sharma, H., Yedlapudi, D., Antonio, T., Reith, MAE., Dutta, AK, Novel multifunctional dopamine D2/D3 receptors agonists as modulator of aggregation of alpha synuclein protein with potential neuroprotective property. Bioorganic & Medicinal Chemistry, 24, 5088–5102, doi: 10.1016/j.bmc.2016.08.021. 2016.

Amjad, W., Kesharwani, P., Cairul Iqbal Mohd Amin, M., and Iyer, AK.*. Recent advances in the design, development, and targeting mechanisms of polymeric micelles for delivery of siRNA in cancer therapy. Progress in Polymer Science., 64, 154-181. doi: 10.1016/j.progpolymsci.2016.09.008, (*Corresponding author), 2016.

Luong, D., Sau, S., Kesharwani, P. and Iyer, AK*. Polyvalent Folate-Dendrimer-Coated Iron Oxide Theranostic Nanoparticles for Simultaneous Magnetic Resonance Imaging and Precise Cancer Cell Targeting. Biomacromolecules, 18 (4), pp 1197–1209, doi: 10.1021/acs.biomac.6b01885 (*Corresponding Author), 2016.

Wickens, JM., Alsaab, HO., Kesharwani, P., Bhise, K., Cairul Iqbal Mohd Amin, M., Tekade, RK., Gupta, U. and Iyer, AK.*. Recent Advances in Hyaluronic Acid Decorated Nanocarriers for Targeted Cancer Therapy. Drug Discovery Today, doi: 10.1016/j.drudis.2016.12.009 (*Corresponding Author), 2016.

Sharma, AK., Gothwal, A., Kesharwani, P., Alsaab, H., Iyer, AK., Gupta, U. Dendrimer Nano-Architectures for Cancer Diagnosis and Anticancer Drug Delivery. Drug Discovery Today, http://doi.org/10.1016/j.drudis.2016.09.013, 2016.

Mishra, M., Mishra, VK., Kashaw, V., Iyer, AK., Kashaw, SK. Comprehensive review on current strategies for antimalarial drug discovery. European Journal of Medicinal Chemistry, doi: 10.1016/j.ejmech.2016.11.025, 2016.

Wickens, JM., Alsaab, HO., Kesharwani, P., Bhise, K., Cairul Iqbal Mohd Amin, M., Tekade, RK., Gupta, U., Iyer, AK.*. Recent Advances in Hyaluronic Acid Decorated Nanocarriers for Targeted Cancer Therapy. Drug Discovery Today. doi: 10.1016/j.drudis.2016.12.009, 2016.

Gawde, K., Kesharwani, P., Sau, S., Sarkar, FH., Padhye, S., Kashaw, SK., Iyer, AK.*. Synthesis and Characterization of Folate Decorated Albumin Bio-conjugate Nanoparticles loaded with a Synthetic Curcumin Difluorinated Analogue. Journal of Colloid and Interface Science, DOI:10.1016/j.jcis.2017.01.092 *Corresponding Author, 2016.

Eng Ng, K., MCIM Amim, Katas, H., Wahab, M., Butt, AM., Kesharwani, P., Iyer, AK. pH-Responsive Triblock Copolymeric Micelles Decorated with a Cell-Penetrating Peptide Provide Efficient Doxorubicin Delivery. Nanoscale Research Letters. DOI: 10.1186/s11671-016-1755-4 2016.

Nitin Dwivedi, Jigna Shah, Vijay Mishra, Mohd Cairul Iqbal Mohd Amin, Arun K. Iyer, Prashant Kesharwani. Dendrimer Mediated Approaches for Treatment of Brain Tumor. Journal of Biomaterials Science, Polymer Edition; 27(7) 557-580, DOI:10.1080/09205063.2015.1133155 2016.

Jain, A., Jain, A., Jain, AK., Garg, NK., Raj Singh, TR., Iyer, AK., Kesharwani, P. Cationic Bovine Serum Albumin (CBA) conjugated Poly Lactic-co-Glycolic Acid (PLGA) nanoparticles for extended delivery of methotrexate into brain tumor. RSC Advances, 6, 89040-89050, doi: 10.1039/C6RA17290C 2016.

28

Luong, D., Kesharwani, P., Deshmukh, R., Cairul Iqbal Mohd Amin, M., Gupta, U., Greish, K., Iyer, AK.* PEGylated PAMAM Dendrimers: Enhancing Efficacy and Mitigating Toxicity for Effective Anticancer Drug and Gene Delivery. Acta Biomaterilia ,43:14-29. http://doi.org/10.1016/j.actbio.2016.07.015 (*corresponding author), 2016.

Khan I, Gothwal A, Sharma AK, Kesharwani P, Gupta L, Iyer AK, Gupta U. PLGA nanoparticles and their versatile role in anticancer drug delivery. Critical Reviews in Therapeutic Drug Carrier Systems.33(2) 159-193. doi: 10.1615/CritRevTherDrugCarrierSyst.2016015273, 2016.

Kowluru, A. A lack of glue misplaces Rab27A to cause islet dysfunction in diabetes. J Pathol 238:375-377, doi:10.1002/path.4671, 2016.

Zhang, X., Damacharla, D., Ma, D., Qi, Y., Tagett, R., Draghici, S., Kowluru, A. and Yi, Z,: Quantitative proteomics reveals novel protein interaction partners of PP2A catalytic subunit in pancreatic β-cells, Molecular and Cellular Endocrinology, 424:1-11, doi: 10.1016/j.mce.2016.01.008, 2016.

Veluthakal, R., Sidarala, V., Kowluru, A.: NSC23766, a known inhibitor of Tiam1-Rac1 signaling module, prevents the onset of type 1 diabetes in the NOD mouse model. Cell Physiol Biochem 39:760-767, https://doi.org/10.1159/000445666, 2016.

Kowluru, RA., Mishra, M., Kowluru, A., Kumar, B.: hyperlipidemia and the development of diabetic retinopathy: Comparison between type1 and type 2 animal models. Metabolism 65:1570-1581, DOI:10.1016/j.metabol.2016.07.012, 2016.

Veluthakal, R., Arora, DK., Goalstone, ML., Kowluru, RA. and Kowluru, A.: Metabolic stress induces caspase-3 mediated degradation and inactivation of farnesyl and geranylgeranyl transferase activities in pancreatic β-cells. Cell Physiol Biochem 39:2110-2120, DOI: 10.1159/000447907, 2016.

Sidarala, V. and Kowluru, A.: The regulatory roles of mitogen-activated protein kinase (MAPK) pathways in health and diabetes: Lessons learnt from the pancreatic beta-cell Recent Patents on Endocrine, Metabolic and Immune Drug Discovery, E-published in 2016.

Cohen, J.D., Labenski, M.T., Mastrandrea, N.J., Canatsey, R.D., Monks, T.J. and Lau, S.S. Transcriptional and post-translational modifications of B-Raf in quinol-thioether induced tuberous sclerosis renal cell carcinoma. Mol Carcinogenesis, 55:1243-1250, DOI: 10.1002/mc.22366 2016.

Kinsky, O.R., Hargraves, T.L., Anumol, T. Jacobsen, N.E., Dai, J., Shane A. Snyder, S.A., Monks, T.J. and Lau, S.S. Metformin scavenges methylglyoxal to form a novel imidazolinone metabolite in humans. Chem Res Toxicol, 29(2):227-234, DOI: 10.1021/acs.chemrestox.5b00497, 2016.

Cholanians A.B., Phan A.V., Ditzel E.J., Camenish T.D., Lau S.S., and Monks T.J. Arsenic induces accumulation of a-Synuclein: Implications for synucleinopathies and neurodegeneration. Toxicol Sci. DOI: https://doi.org/10.1093/toxsci/kfw117, 2016.

Xu, H., Radabaugh, T., Lu, Z., Billheimer, D., Vercelli, D., Wright, A.L., Halonen, M. and Lau, S.S. Exploration of early life candidate biomarkers for childhood asthma using antibody arrays. Ped Allergy and Immunology. NIHMS804887., DOI: 10.1111/pai.12613, 2016.

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Xie, Y., Killinger, B., Moszczynska, A., Merkel, OM.*: Targeted Delivery of siRNA to Transferrin Receptor Overexpressing Tumor Cells via Peptide Modified Polyethylenimine. Molecules, 21 (10), pii: E1334*Corresponding Author, DOI: 10.3390/molecules21101334, 2016.

Mohammadi, M., Li, Y., Abebe, DG., Xie, Y., Kandil, R., Kraus, T., Gomez-Lopez, N., Fujiwara, T., Merkel, OM.*: Folate receptor targeted three-layered micelles and hydrogels for gene delivery to activated macrophages. Journal of Controlled Release, 244 (Pt B), 269-279*Corresponding Author, DOI: 10.1016/j.jconrel.2016.08.020, 2016.

Movassaghian, S., Hildebrandt, C., Xie, Y., Li, Y., Rosati, R., Yang, Z., Merkel, OM.*: Post-transcriptional regulation of the GASC1 oncogene with active tumor-targeted siRNA-nanoparticles Molecular Pharmaceutics, 13 (8), 2605-21, DOI: 10.1021/acs.molpharmaceut.5b00948, *Corresponding Author, 2016.

Zhong, Q., Merkel, OM., Reineke, JJ., R da Rocha, S.: Effect of the Route of Administration and PEGylation of Poly(amidoamine) Dendrimers on Their Systemic and Lung Cellular Biodistribution. Molecular Pharmaceutics, 13 (6), 1866-78, DOI: 10.1021/acs.molpharmaceut.6b00036, 2016.

Xie, Y., Kim, NH., Nadithe, V., Thakur, A., Lum, L., Bassett, DJP., Merkel, OM.*: Targeted delivery of siRNA to activated T cells via transferrin-polyethylenimine (Tf-PEI) as a potential therapy of asthma, Journal of Controlled Release, 229, 120-9, DOI: 10.1016/j.jconrel, 2016.

Jones, S., Lizzio, V., Merkel, OM.*: Folate Receptor Targeted Delivery of siRNA and Paclitaxel to Ovarian Cancer Cells via Folate Conjugated Triblock Co-polymer to Overcome TLR4 Driven Chemotherapy Resistance Biomacromolecules, 17 (1), 76-87 *Corresponding Author, DOI: 10.1021/acs.biomac.5b01189, 2016.

Liu, L., Zheng, M., Librizzi, D., Renette, T., Merkel, OM.*, Kissel, T.: Efficient and tumor targeted siRNA delivery by polyethylenimine-graft-polycaprolactone-block-poly (ethylene glycol)-folate (PEI- PCL-PEG-Fol) Molecular Pharmaceutics, 13 (1), 134-43, DOI:10.1021/acs.molpharmaceut.5b00575, *Corresponding Author, 2016.

Cho, S., Islas-Robles, A., Nicolini, A.M., Monks, T.J., and Yoon, J-Y. In situ, dual-mode monitoring of organ-on-a-chip with a smartphone-based fluorescence microscope. Biosensors and Bioelectronics PMID 27474967 (IF 7.47), 86, 697-705, DOI: 10.1016/j.bios.2016.07.015, 2016.

Killinger, B.A.* and Moszczynska, A. Epothilone D prevents binge methamphetamine-mediated loss of striatal dopaminergic markers. J. Neurochem. 136:510-25, DOI: 10.1111/jnc.13391, 2016.

Tong J, Fitzmaurice PS, Moszczynska A, Mattina K, Ang LC, Boileau I, Furukawa Y, Sailasuta N, Kish SJ. Do glutathione levels decline in ageing human brain? Free Radic. Biol. Med. 93:110-7, DOI: 10.1016/j.freeradbiomed.2016.01.029, 2016.

Killinger, B.A.* and Moszczynska, A. The Characterization of α-synuclein multimer assembly and stoichiometry in complex biological samples by electrophoresis. ACS Anal. Chem. 88:4071-84, DOI: 10.1021/acs.analchem.6b00419, 2016.

Luong D, Kesharwani P, Killinger BA*, Moszczynska A, Sarkar FH, Padhye S, Rishi AK, Iyer AK. Solubility enhancement and targeted delivery of a potent anticancer flavonoid analogue to

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cancer cells using folate decorated dendrimer nano-architectures. J. Colloid Interface Sci. 484:33., DOI:10.1016/j.jcis.2016.08.061, 2016.

Moszczynska, A. Methamphetamine Neurotoxicity. Psychiatr. Times 33:16-8, 2016. Liao, Y., Niu, X., Chen, B., Edwards, H., Xu, L., Xie, C., Lin, H., Polin, L., Taub, LW., Ge, Y.,

Qin, Z. Synthesis and antileukemic activities of piperlongumine and HDAC Inhibitor hybrids against acute myeloid leukemia cell, Journal of Medicinal Chemistry, 7974-7990, DOI: 10.1021/acs.jmedchem.6b00772, 2016.

Rosati, R., Chen, B., Patki, M., McFall, T., Ou, S., Heath, E., Ratnam, M., Qin, Z. Hybrid enzalutamide derivatives with histone deacetylase inhibitor activity decrease heat shock protein 90 and androgen receptor levels and inhibit viability in enzalutamide-resistant C4-2 prostate cancer cells Molecular Pharmacology, 90(3), 225-237, DOI: https://doi.org/10.1124/mol.116.103416, 2016.

Boppana, NB., DeLor, JS., Van Buren, E., Bielawska, A., Bielawski, J., Pierce, JS., Korbelik, M., Separovic D. Enhanced apoptotic cancer cell killing after Foscan photodynamic therapy combined with fenretinide via de novo sphingolipid biosynthesis pathway. Journal of Photochemistry & Photobiology B: Biology, 159:191-195, DOI: 10.1016/j.jphotobiol.2016.02.040, 2016.

Korbelik, M., Banáth, J., Zhang, W., Saw, KM., Szulc, ZM., Bielawska, A., Separovic, D. Interaction of acid ceramidase inhibitor LCL521 with tumor response to photodynamic therapy and photodynamic therapy-generated vaccine. International Journal of Cancer, 139: 1372-1378, DOI: 10.1002/ijc.30171, 2016.

Barupala, D.P.*; Dzul, S.P.*; Riggs-Gelasco, P.J.; Stemmler, T.L. “Synthesis, Delivery and Regulation of Eukaryotic Heme and Fe-S Cluster Cofactors” Archives In Biochem. Biophys., 15, 60-75, DOI:10.1016/j.abb.2016.01.010, 2016.

Walter, M.R.; Dzul, S.P.*; Rodrigues, A.V.*; Stemmler, T.L.; Tesler, J.; Conradie, J.; Ghosh, A.; Harrop, T.C. “Synthesis of Co(II)-NO(-) Complexes and their reactivity as a Source of Nitroxyl” J. Am. Chem. Soc., 138, 12459-71. DOI: 10.1021/jacs.6b05896, 2016.

Bostelaar, T.; Vitvitsky, V.; Kumutima, J.; Lewis, B.E.*; Yadav, P.K.; Brunold, T.C.; Filipovic, M.; Lehnert, N.; Stemmler, T.L.; Banerjee, R. “Hydrogen Sulfide Oxidation by Myoglobin” J. Am. Chem. Soc., 138, 8476-88, DOI: 10.1021/jacs.6b03456, 2016.

Patel, S.J.; Lewis, B.E.*; Long, J.E.; Nambi, S.; Sassetti, C.M.; Stemmler, T.L.; Arguello, J.M. “Fine Tuning of Substrate Affinity Leads to Alternative Roles of Mycobacterium tuberculosis Fe(III) ATPases” J. Biol. Chem., 291, 4700-5. DOI: 10.1074/jbc.M116.718239, 2016.

Shimberg, G.D.; Michalek, J.L.; Oluyadi, A.D.; Rodrigues, A.V.*; Beth E. Zucconi, B.E.; Neu, H.; Ghosh, S.; Sureschandra, K.; Wilson, G.M.; Stemmler, T.L.; Michel, S.L.J. “Cleavage and Polyadenylation Specificity Factor 30: An RNA binding Zinc Finger Protein with an unexpected 2Fe-2S cluster” Proc. Natl. Acad. Sci, U.S.A., 113, 4700-5, DOI: 10.1073/pnas.1517620113, 2016.

Dandekar, A., Qiu, Y., Kim ,HB., Wang, JM., Xia, H., Zhang, XB., Zheng, Z., Roberto, M., Kim, HB., Yu, FS., Kumar, A., Fang, D., Sun, F., Zhang, K.. TLR Signaling Interacts with CREBH to Modulate HDL in Response to Bacterial Endotoxin. J Biol Chem 291:23149-23158, doi: 10.1074/jbc.M116.755728, 2016.

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Wang, JM*., Chen, AF., Zhang, KZ. Isolation and primary culture of mouse aortic endothelial cells. J Vis Exp 118:e52965, doi: 10.3791/52965 (* Corresponding author), 2016

Wu, K., Li, L., Thakur, C., Lu, Y., Zhang, X., Yi, Z. and Chen, F., "Proteomic Characterization of the World Trade Center dust-activated mdig and c-myc signaling circuit linked to multiple myeloma", Scientific Reports, Nov 11;6;36305. Doi: 10.1038/srep36305, 2016.

Xie, X., Yi, Z., Sinha, S., Madan, M., Bowen, BP., Langlais, P., Ma, D., Mandarino, L. and Meyer, C. "Proteomics Analyses of Subcutaneous Adipocytes Reveal Novel Abnormalities in Human Insulin Resistance". Obesity (Silver Spring). 24 (7):1506-14. doi: 10.1002/oby.21528, 2016.

Liu, Q., Liu, Q., Yi, J., Liang, K., Hu, B., Zhang, X., Curtiss III, R. and Kong, Q. Outer membrane vesicles from flagellin-deficient Salmonella enterica serovar Typhimurium induce cross-reactive immunity and provide cross-protection against heterologous Salmonella challenge. Scientific Reports (5.228); 6: 34776, 2016.

XIV. Book Chapters and Books Abebe, DG., Kandil, R., Kraus, T., Elsayed, M., Fujiwara, T., Merkel, OM.*: Stealth polyplexes:

biodegradable three-layered micelles and injectable hydrogels, Methods Mol Biol. 2016, 1445, 175-85. *Corresponding Author

Jones, SK., Merkel, OM.*: Indium-labeling of siRNA for small animal SPECT imaging, Methods Mol Biol. 2016, 1372, 79-88. *Corresponding Author

Moszczynska, A. Methamphetamine Neurotoxicity and the Ubiquitin-Proteasome System, Neuropathology of Addiction and Substance Misuse. Publisher: Elsevier; Editor: Victor R. Preedy., http://doi.org/10.1016/B978-0-12-800212-4.00017-0, 2016.

XV. Patents Issued or Pending Iyer, AK. and Alsaab, H., Ligand anchored anti PD-1 antibody for efficient targeting and therapy of

cancers Tech ID 16-1390 Invention Disclosure filed under Wayne State University. August 2016. Iyer, AK., An off the shelf method to prepare well protected siRNA nanoplexes using novel 'clickable'

polymers and their targeted delivery to diseased sites for effective gene delivery." Tech ID 16-1360 Invention Disclosure filed under Wayne State University. July 2016.

Qin, Z., Ratnam, M., Anticancer drugs including the chemical structures of an androgen receptor ligand and a histone deacetylase inhibitor; Provisional submission, U.S. patent 62/288,810, submitted by WSU in January 2016.

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XVI. Abstracts Head, D., Botz, A., Lenhardt, S., Murphy, K. and Commissaris, R. The effects of texting on driving

performance in a driving simulator: The influence of driver age. American Occupational Therapy Association (AOTA Conference), 2016.

Luo, D., Das, B., Rajagopalan, S., Xu, L., Joshi, G., Reith, M., Todi, S., Andersen, JK., Dutta, AK. A novel iron (II) preferring dopamine agonist chelator D-607 significantly suppresses α-Syn- and MPTP-induced toxicities in vivo. Grand Challenges in Parkinson’s Diseases, Vanandel Research Institute, Grand Rapids, 2016.

Yedlapudi, D., Joshi, GS., Luo, D., Todi, SV., Dutta, AK. Assessment of inhibition of alpha synuclein aggregation and toxicity by multifunctional dopamine agonists by a novel in vitro assay and an in vivo drosophila synucleinopathy model. Grand Challenges in Parkinson’s Diseases, Vanandel Research Institute, Grand Rapids, 2016.

Kesharwani, P., Alsaab, HO., Sarkar, FH., Iyer, AK., Hyaluronic Acid Conjugated Dendrimers Based Nano-Formulation for Targeted Therapy of Pancreatic Cancer. Cancer Metabolism Symposium, University of Michigan, 2016.

Alsaab, H., Kesharwani, P., Cheryan, VT., Rishi, AK. and Iyer, AK. CARP-1 functional mimetic loaded in Vitamin E-TPGS micellar nano-formulation for treating renal cell carcinoma. 13th Annual Research Forum, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 2016.

Alsaab, HO., Streeter, C., Gadgeel, S., Firstine, SM. and Iyer, AK. Ligand Anchored Anti PD-1 Antibody for Targeting and Imaging of Disease Sites. 13th Annual Research Forum, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 2016.

Alsaab, H. O., Streeter, C., Gadgeel, S., Firestine, SM. and Iyer, AK. Ligand Anchored Anti PD-1 Antibody for Targeting and Imaging of Disease Sites. Graduate Student Research Day, Wayne State University, 2016.

H. O. Alsaab, P. Kesharwani , S. Padhye, F.H. Sarkar, A.K. Iyer. Hyaluronic Acid Anchored PAMAM Dendrimer Mediated Delivery of 3,4-difluorobenzylidene Diferuloylmethane to CD44 Overexpressing Pancreas Cancer Cells. AAPS Meeting at Denver, CO, 2016.

Kesharwani, P., Alsaab, H. O., Padhye, S., Sarkar, F.H., Iyer. A.K. Hyaluronic Acid Decorated Nanomicelles Loaded with a Potent Anticancer Flavonoid Analogue to CD44 Expressing Stem- Like Pancreatic Cancer Cells. AAPS at Meeting Denver, CO, 2016.

Luong, D., Kesharwani, P., Iyer, AK. Multifunctional Dendrimer-Coated Iron Oxide Theranostic Nanoparticles for Active Targeting Magnetic Resonance Imaging and Cancer Therapy. The 13th Annual EACPHS Research Forum, 2016.

Alsaab, H. O., Kesharwani, P., Padhye, S., Sarkar, F.H., Iyer, A.K. Folic acid-Decorated Polymeric Nanomicelles for Targeted Delivery of a Potent Flavonoid Analogue to Folate Overexpressing Cancers. AAPS Meeting at Denver, CO, 2016.

Luong, D., Kesharwani, P., Deshmukh, R., Iyer, AK. Dendrimer-Coated Iron Oxide Theranostic Nanoparticles for Cancer Imaging and Therapy. AAPS Meeting at Denver, CO, 2016.

Alsaab, H., Kesharwani, P., Cheryan, VT., Rishi, AK. and Iyer, AK. CARP-1 functional mimetic loaded in Vitamin E-TPGS micellar nano-formulation for treating renal cell carcinoma. Graduate Student Research Day, Wayne State University, 2016.

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Luong, D., Kesharwani, P., Iyer, AK. Dendrimer-Coated Iron Oxide Theranostic Nanoparticles for Cancer Imaging and Therapy. Cancer Metabolism Symposium, University of Michigan, Ann Arbor, MI, 2016.

Gawde, K. and Iyer, AK. Albumin Bioconjugate Nanoparticles for the Treatment of Ovarian Cancer. The 13th Annual EACPHS Research Forum, 2016.

Wang, Z., Iyer, AK. Redox Responsive Cerium Oxide Nanoparticles for Lung Cancer Therapy. The 13th Annual EACPHS Research Forum, 2016.

Luong, D., Wang, Y., Kesharwani, P., Iyer, AK. Polyamidoamine Dendrimer Decorated Iron Oxide Theranostic Nanoparticles for Cancer Imaging and Therapy. The 13th Annual EACPHS Research Forum, 2016.

Wang, Z., Iyer, AK. Redox Responsive Cerium Oxide Nanoparticles for Lung Cancer Therapy. Graduate Student Research Day, Wayne State University, Detroit, MI, 2016.

Luong, D., Wang, Y., Kesharwani, P., Iyer, AK. Polyamidoamine Dendrimer Decorated Iron Oxide Theranostic Nanoparticles for Cancer Imaging and Therapy. Graduate Student Research Day, Wayne State University, 2016.

Luong, D., Kesharwani, P., Alsaab, H., Alzhrani, R., Sarkar, FH., Padhye, S., Rishi, AK. and Iyer, AK. Folic Acid Decorated Polymeric Micelles Loaded with 3,4-Difluorobenzylidene Diferuloylmethane for Targeting Cervical and Ovarian Cancers. The 13th Annual EACPHS Research Forum, 2016.

Gawde, K. and Iyer, AK. Albumin Bioconjugate Nanoparticles for the Treatment of Ovarian Cancer. Graduate Student Research Day, Wayne State University, 2016.

Luong, D., Kesharwani, P., Alsaab, H., Alzhrani, R., Sarkar, FH., Padhye, S., Rishi, AK. and Iyer, AK. Folic Acid Decorated Polymeric Micelles Loaded with 3,4-Difluorobenzylidene Diferuloylmethane for Targeting Cervical and Ovarian Cancers. Graduate Student Research Day, Wayne State University, 2016.

Luong, D., Kesharwani, P., Iyer, AK. Multifunctional Dendrimer-Coated Iron Oxide Theranostic Nanoparticles for Active Targeting Magnetic Resonance Imaging and Cancer Therapy. Graduate Student Research Day, Wayne State University, 2016.

Kashaw, SK., Agrawal, S. and Iyer. AK. Development of in-silico QSAR models of 1,2,4 Oxadiazole derivatives as potential apoptosis inducer and anticancer agents. The 13th Annual EACPHS Research Forum, October 2016.

Yousef,SM., Bhise, KS., and Iyer, AK. Modular Bio-orthogonal Click Reaction for Designing Multifunctional Nanoparticles for Targeted Cancer Therapy. The 13th Annual EACPHS Research Forum, 2016.

Monks, T.J., Cholanians, A.B., Lizarraga, L.L., Phan A.V. and Lau, S.S. Concurrent inhibition of vesicular monoamine transporter 2 does not protect against 3,4-methylenedioxymethamphetamine (MDMA; Ecstasy) induced neurotoxicity. Toxicologist, 150: 57, 2016.

Cholanians, A.B., Lau S.S. and Monks, T.J. Arsenic induces in vitro and in vivo accumulation of alpha-synuclein: implications in Parkinson’s disease. Toxicologist, 150: 140, 2016.

Lau, S.S., Cholanians, A.B. and Monks, T.J. Dopamine and L-DOPA induced post-translational modifications of alpha-synuclein. Toxicologist, 150: 326, 2016.

Sapiro, J.M., Burrell, K.L. and Lau, S.S. All-trans-retinoic acid mediated stress protein induction and modification afford cytoprotection against renal injury. Toxicologist, 150: 376, 2016.

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Le, G.T., Canatsey, R.D., Tran, K., Monks, T.J. and Lau, S.S. Pentoxifylline modulates the AKT/mTOR/AMPK pathway: potential role as an adjunct in cancer chemotherapy. The FASEB Journal, 30: 633.9, 2016.

Sapiro, J.M., Burrell, K.L. and Lau, S.S. Molecular mechanisms of all-trans-retinoic acid mediated cytoprotection against renal cell injury. The FASEB Journal, 30: 711.4, 2016.

Islas-Robles, A, (Frances M. Muñoz, F.M., Lau, S.S., and Monks, T.J. Relative abundance comparative analysis of ROS-induced Poly(ADP-ribose)-associated proteins by LC-MS/MS Spectral Counting. J. Am. Soc. Mass. Spec., 2016.

Mehta, A.,Stathopoulos, GT., Merkel, OM.: Inhalable Nanoparticles for In Vivo Genome Editing Mediated by CRISPR-CAS9 Delivery for Undruggable KRAS Driven Lung Cancers

Mohammadi, M., Li, Y., Kandil, R., Abebe, DG., Xie, Y., Fujiwara, T., Merkel, OM: In-situ forming gel devices as local depot therapeutic for Rheumatoid, 2016.

Kandil, R., Xie, Y., Kim, NH., Nadithe, V., Thakur, A., Lum, LG., Bassett, DJP., Merkel, OM.: Transferrin-Polyethylenimine Nanoparticles for T Cell Targeted siRNA Delivery as Novel Anti-inflammatory Asthma Therapy, 2016.

Mohammadi, M., Li, Y., Kandil, R., Abebe, DG., Xie, Y., Fujiwara, T.,Merkel, OM.: In-situ forming gel devices as local depot therapeutic for Rheumatoid, 2016.

Kandil, R., Xie, Y., Kim, NH., Nadithe, V., Thakur, A., Lum, LG., Bassett, DJP., Merkel, OM.: Transferrin-Polyethylenimine Nanoparticles for T Cell Targeted siRNA Delivery as Novel Anti-inflammatory Asthma Therapy, 2016.

Steven Jones, Vincent Lizzio, Kirk Douglas, Xin Lu, Ramandeep Rattan, Anthony Shields, Olivia M Merkel: Receptor Targeted Delivery of siRNA and Paclitaxel to Ovarian Cancer Cells via Folate Conjugated Triblock Copolymer to Overcome TLR4 Driven Chemotherapy Resistance, 2016.

Xie, Y., Kim, NH., Thakur, A., Lum, L., Bassett, D., Merkel, OM: In vivo siRNA delivery to activated T cells as novel anti-inflammatory asthma therapy, 2016.

Feldmann, D., Xie, Y., Merkel, OM.: Synthesis and Characterization of Oligospermine Nanoparticles for Inhaled siRNA Delivery System, 2016.

Jones, S., Lizzio, V., Douglas, K., Lu, X., Rattan, R., Shields, A., Merkel, OM.: Receptor Targeted Delivery of siRNA and Paclitaxel to Ovarian Cancer Cells via Folate Conjugated Triblock Copolymer to Overcome TLR4 Driven Chemotherapy Resistance, 2016.

Feldmann, D., Xie, Y., Merkel, OM.: Microfluidic Mixing of Nanoparticle-based siRNA Therapeutics, 2016.

Jones, S., Lizzio, V., Douglas, K., Lu, X., Rattan, R., Shields, A., Merkel,OM.: Receptor Targeted Delivery of siRNA and Paclitaxel to Ovarian Cancer Cells via Folate Conjugated Triblock Copolymer to Overcome TLR4 Driven Chemotherapy Resistance, 2016.

Moszczynska, A., Gemechu, J.M. and Killinger*, B.A. Knockout of Park2 Gene Alters dopamine and phenylethylamine signaling in the rat striatum: the insight into the role of E3 ligase parkin in neuroprotection. 9th Symposium on Neuroprotection and Neurorepair. Leipzig, Germany, 2016.

Moszczynska, A. and Killinger*, B.A. Knockout of Park2 gene alters dopamine and phenylethylamine signaling in the rat striatum: the insight into the role of E3 ligase parkin in neuroprotection. 43rd Annual Pharmacology Research Colloquium, Ann Arbor, MI, USA, 2016.

Moszczynska, A., Rhinesmith, T.* and Killinger, B.A.* Multimer-PAGE: A method for capturing and resolving protein complexes in biological samples. WSU Undergraduate Students Poster Day. Detroit, USA. 2016.

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Moszczynska, A., Jickssa M. Gemechu and Bryan A. Killinger*. Parkin knockout rats develop parkinsonian-like motor impairments upon exposure to psychostimulant methamphetamine. Dopamine 2016, Vienna, Austria. 2016.

Sharma, A.* and Moszczynska, A. Effects of chronic meth administration in parkin-deficient rats. Brain Storm 2016. Detroit, USA, 2016.

Yu, D.* and Moszczynska, A. Methamphetamine-induced increases in LINE-1 in cell death (oral presentation). Brain Storm 2016. Detroit, USA, 2016.

Sharma, A.* and Moszczynska, A. Effects of chronic meth administration in parkin-deficient rats. Eugene Applebaum College of Pharmacy and Health Sciences, Detroit, MI, USA, 2016.

Yu, D.* and Moszczynska, A. Methamphetamine-induced increases in LINE-1 in cell death. Eugene Applebaum College of Pharmacy and Health Sciences, Detroit, MI, USA, 2016.

Killinger, B.A. and Moszczynska, A. Multimer-PAGE: A method for capturing and resolving protein complexes in biological samples. The 46th Annual Meeting of the Society for Neuroscience”. San Diego, CA, USA, 2016.

McElmurry, S.P., Zahran, S., Pitts, D.K., Sperone, F.G.: Triazines in surface and groundwater enhance risk of congenital birth defects Fifth International Conference on Emerging Contaminants (EmCon2016) and Micropollutants (WiOW2016), University of Technology, Sydney, Australia, 2016.

Pitts, D.K., Matta, V., Albanese, K.A., Gall, C., McElmurry, S.P., Chin, Y-P, Lanno, R.: Triclosan and triclocarban antibiotics: Toxicity of parent compounds and photodegredates in Daphnia, Fifth International Conference on Emerging Contaminants (EmCon2016) and Micropollutants (WiOW2016), University of Technology, Sydney, Australia, 2016.

XVII. Departmental Seminars Winter 2016 January 13: Approach towards the development of symptomatic and disease modifying therapeutics

for Parkinson's disease. Dan Luo, Year 3 PhD Student Seminar January 20: Design, synthesis and antimicrobial activity of N5-CAIR synthetase inhibitors. Qian

Lin, Year 3 PhD Student Seminar January 27: Global Kinome Interactome in human skeletal muscle from lean and obese participants.

Yue Qi, Year 3 PhD Student Seminar February 3: Investigating the mechanism of Isatin inhibition of the microbial enzyme N5-CAIR

Synthetase. Cale Streeter, Year 3 PhD Student Seminar February 10: Unveiling the underlying mechanisms of arsenic induced tumorigenesis: from the view

of epigenetics and metastasis. Lingzhi Li, Year 3 PhD Student Seminar February 17: Targeted delivery of siRNA to activated T cells via Transferrin-Polyethylenimine (Tf-

PEI) as a potential therapy of asthma. Yuran Xie, Year 3 PhD Student Seminar February 24: Mechanisms of pancreatic beta-cell dysfunction in diabetes. Vaibhav Sidarala, Year 3

PhD Student Seminar March 2: Adventures in antimicrobial drug discovery. Dr. Steven Firestine, Associate Professor,

Department of Pharmaceutical Sciences, Wayne State University; University

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March 9: Advancing lipid gene discoveries to innovative targets for CVD. Dr. Eugene Chen, Frederick Huetwell Professor of Cardiovascular Medicine, University of Michigan Medical Center

March 16: Natural products and nanomedicine to eliminate cancer stem cells. Dr. Duxin Sun, Department of Pharmaceutical Sciences, University of Michigan

March 23: Serving the best interests of our students, our teaching programs, and the future faculty, all in one fell swoop. Dr. Brian Coppola, Department of Chemistry, University of Michigan

March 30: Phenotypic and serotoninergic targets for therapeutics in addictive disorders. Dr. Kathryn Cunningham, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX

April 6: Oxidative Damage and Environmental Carcinogenesis. Dr. Tom Hei, Center for Radiological Research, Columbia University

April 12: Approaches for localized delivery to solid tumors. Dr. Hamid Ghandehari, Departments of Pharmaceutics & Pharmaceutical Chemistry, and Bioengineering, University of Utah

April 13: Insights on DNA repair enzymes from computational simulations. Dr. C. Andres Cisneros, Department of Chemistry, Wayne State University

Fall 2016 September 7: New Hsp90 Inhibitors from Old Drugs Dr. Brian Blagg, Professor of Medicinal

Chemistry, University of Kansas, Lawrence, Kansas September 14: Challenges for the Toxicologist in the Courtroom: the 5 Question Approach to

Specific Causation Dr. Sol Bobst, Senior Regulatory Compliance & Toxicology Advisor, NEXEO Solutions, The Woodlands, TX

September 21: Frataxin, mitochondrial energetics and heart failure. Dr. Rajesh Amin, Assistant Professor of Drug Discovery and Development, Auburn University, Auburn, AL

September 28: Nrf2 in Environmental Response and Disease Intervention Dr. Donna Zhang, Professor, Departments of Pharmacology and Toxicology, University of Arizona, Tuscon, AZ

September 30: When metalloproteins go rogue: application of metalloproteomics to discover drug mechanism of action in neurodegenerative diseases Dr. Blain Roberts, Associate Professor, Department of Medicine, the University of Melbourne, Melbourne, Australia

October 19: Novel Role for a Bone-related Pathway in the Pancreatic Beta Cell Dr. Rupangi Vasavada, Assoc. Professor of Medicine, Icahn School of Medicine at Mount Sinai, Ney York, NY

October 26: Proteolytic Control of DNA Repair, Reproduction and Tumorigenesis Dr. Pengbo Zhou, Professor of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, Ithaca, NY

November 2: Targeting TXNIP as a potential therapy for diabetes Dr. Anath Shalev, Professor of Medicine, Endowed Chair in Juvenile Diabetes Research, University of Alabama at Birmingham, Birimgham, AL

November 16: Don’t put all your eggs in one basket: A possible role for Riboflavin Binding in Copper Transport and Storage in Oviparous Species. Dr. Sheila Smith, University of Michigan, Dearborn, Dearborn, MI

November 30: Metals in Medicine: From zinc sites in biology to iron nanoparticle based drugs, Dr. Sarah Michel, Department of Pharmaceutical Sciences, University of Maryland, Baltimore, MD

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December 7: Shaping Next Generation Aminoglycoside Antibiotics for Treatment of Multidrug-Resistant Diseases Dr. David Crich, Schaap Professor of Organic Chemistry, Department of Chemistry, Wayne State University, Detroit, MI

December 14: "Methamphetamine Induces Anhedonic-Like Behaviour and Impairs Frontal Cortical Energetics in Mice" Akhil Sharma, 2nd Year PhD Student Seminar (PSC 7870), Department of Pharmaceutical Sciences, Wayne State University, Detroit, MI

December 21: "Overview of Photodynamic therapy (PDT) of cancer". Hashem Alsaab, 2nd Year PhD Student Seminar (PSC 7870), Department of Pharmaceutical Sciences, Wayne State University, Detroit, MI