1

Department of Pharmaceutical chemistry

list of publications

2

List of Publication of

KHALED ABOUZID MOHAMAD

Professor of Pharmaceutical Chemistry

Vice dean of educational and students affairs

Faculty of Pharmacy Ain Shams University

----------------------------------------------------------------------------------

1 ldquoSynthesis of 14-Disubstituted Piperazines as Potential Antihypertensive Agentsrdquo K A M Abou-Zeid K M Youssef F M Amine S Botros and Z Isaa Egypt J Pharm Sci Vol 30 No 1-4 pp 429-436 (1989)

2 ldquoSynthesis and Antihypertensive Activity of 14-Disubstituted Piperazinesrdquo K A M Abou-Zeid K M Youssef F M Amine and S Botros Egypt J Pharm Sci Vol 32 No 1-2 pp 165-174 (1991)

3 ldquo6-[4-(Substituted-Amino)Phenyl]-45-Dihydropyridazin-3(2H)-ones as Cardiotonic Agentsrdquo K A M Abou-Zeid K M Youssef MA Shaaban FA El-Telbany and SH Al-Zanfaly Bull Fac Pharm Cairo Univ Vol 33 pp 9-11 (1995)

4 ldquoSynthesis and Phosphodiesterase Inhibiting Activity of Some 6-Substituted-45-Dihydropyridazin-3(2H)-onesrdquo K A M Abou-Zeid K M Youssef MA Shaaban FA El-Telbany and SH Al-Zanfaly Bull Fac Pharm Cairo Univ Vol 33 pp 25-28 (1995)

5 ldquoSynthesis of Novel 45-Dihydropyridazin-3(2H)ones Derivatives with Benzoxazine and Benzoxazole Heterocycles at the 6- Position as Cardiotonic agentsrdquo K A M Abou-Zeid K M Youssef MA Shaaban FA El-Telbany and SH Al-Zanfaly Egypt J Pharm Sci 38 303 (1997)

6 ldquoSynthesis of 6-[4-(Substituted-amino)phenyl]-45-Dihydro-pyridazin-3(2H)ones as Potential positive Inotropic Agentsrdquo K A M Abou-Zeid K M Youssef MA Shaaban FA El-Telbany and SH Al-Zanfaly Egypt J Pharm Sci 38 319 (1997)

7 ldquoHead Group Analogs of Arachidonylethanolamide the Endogenous Cannabinoid Ligandrdquo A D Khanolkar V Abadji S Lin W A G Hill G Taha K Abouzid Z Meng P Fan and A Makriyannis J Med Chem 39 pp4515-4519 (1996) httpdxdoiorg101021jm960152y

8 Substrate Specificity And Stereoselectivity Of Rat Brain Microsomal Anandamide Amidohydrolaserdquo Lang W C Qin S Lin AD Khanolkar A Goutopoulos P Fan K Abouzid Z

3

Meng D Biegel and A Makriyannis J Med Chem 42 pp 896-902 (1999)

httpdxdoiorg101021jm980461j

9 ldquoSynthesis and Evaluation for Potential Antihypertensive Activity of a Series of Substituted Imidazolinone Oximes and Cyclohexanespiro-8-imidazo[51-c]-124-oxdiazinesrdquo Mohamed Abdel Hamid Ismail Khaled Abouzid Awatef E Farag and Amani E Khalifa Alex J Pharm Sci 14(2) pp 151-161 (2000)

10 Synthesis and Antihypertensive Activity of Novel benzimidazole benzoxazole and benzothiazole derivatives Khaled Abouzid Hanan Refaat Maha Abdel Hakeem and Ashraf B Abdel-Naim Bull Fac Pharm Cairo Univ 40(1) pp 7-12 (2002)

11 ldquoSynthesis of Certain Substituted Quinoxalines as Antimicrobial Agents (Part I)rdquo Mohga M Badran Khaled A M Abouzid and M H M Hussein Az J Pharm Sci 30 57 (2002)

12 ldquoSynthesis of Certain Thienopyrimidine Derivatives as Antimicrobial Agentsrdquo A A Mouneer Khaled A M Abouzid and M M Said Az J Pharm Sci 30 150 (2002)

13 ldquoSynthesis of Certain 5678-tetrahydrobenzo[b]thienopyrimidines Fused with Various Heterocyclic Ring Systems as Potential Antihypertensive Agentsrdquo Mohamed Abdel Hamid Ismail Mohammed Nabil Y Aboul-Einein Khaled Abouzid Sahar Kandil Alex J Pharm Sci 15(2) 143 (2002)

14 ldquoSynthesis and Antimicrobial Activity of Certain Substituted Quinoxalines (Part II) rdquo Mohga M Badran Khaled A M Abouzid and and M H M Hussein Arch Pharm Res 26 2 pp 107-113 (2003) httpaprpskorkr

15 ldquoSynthesis and Antiinflammatory Activity of Novel Indazolonesrdquo Khaled A M Abouzid and H S El-Abhar Arch Pharm Res 26 1 pp 1-8 (2003) (Springer) httpaprpskorkr

16 ldquoSynthesis and Biological Evaluation of New Thiazololpyrimidinesrdquo Makarem Said Khaled A M Abouzid

Ashraf Mouneer Arch Pharm Res 27 pp 471-477 (2004) (Springer) httpaprpskorkr

17 ldquoAntipyretic Antinoceceptive and Anti-inflammatory Activity of Certain oxbutanoic Acid Derivativesrdquo Khaled AM Abouzid Khairia M Youssef Amany A E Ahmed and Hanna Hussain Al-Zuhair Med Chem Res 141 pp 26-39 (2005)

2

List of Publication of

KHALED ABOUZID MOHAMAD

Professor of Pharmaceutical Chemistry

Vice dean of educational and students affairs

Faculty of Pharmacy Ain Shams University

----------------------------------------------------------------------------------

1 ldquoSynthesis of 14-Disubstituted Piperazines as Potential Antihypertensive Agentsrdquo K A M Abou-Zeid K M Youssef F M Amine S Botros and Z Isaa Egypt J Pharm Sci Vol 30 No 1-4 pp 429-436 (1989)

2 ldquoSynthesis and Antihypertensive Activity of 14-Disubstituted Piperazinesrdquo K A M Abou-Zeid K M Youssef F M Amine and S Botros Egypt J Pharm Sci Vol 32 No 1-2 pp 165-174 (1991)

3 ldquo6-[4-(Substituted-Amino)Phenyl]-45-Dihydropyridazin-3(2H)-ones as Cardiotonic Agentsrdquo K A M Abou-Zeid K M Youssef MA Shaaban FA El-Telbany and SH Al-Zanfaly Bull Fac Pharm Cairo Univ Vol 33 pp 9-11 (1995)

4 ldquoSynthesis and Phosphodiesterase Inhibiting Activity of Some 6-Substituted-45-Dihydropyridazin-3(2H)-onesrdquo K A M Abou-Zeid K M Youssef MA Shaaban FA El-Telbany and SH Al-Zanfaly Bull Fac Pharm Cairo Univ Vol 33 pp 25-28 (1995)

5 ldquoSynthesis of Novel 45-Dihydropyridazin-3(2H)ones Derivatives with Benzoxazine and Benzoxazole Heterocycles at the 6- Position as Cardiotonic agentsrdquo K A M Abou-Zeid K M Youssef MA Shaaban FA El-Telbany and SH Al-Zanfaly Egypt J Pharm Sci 38 303 (1997)

6 ldquoSynthesis of 6-[4-(Substituted-amino)phenyl]-45-Dihydro-pyridazin-3(2H)ones as Potential positive Inotropic Agentsrdquo K A M Abou-Zeid K M Youssef MA Shaaban FA El-Telbany and SH Al-Zanfaly Egypt J Pharm Sci 38 319 (1997)

7 ldquoHead Group Analogs of Arachidonylethanolamide the Endogenous Cannabinoid Ligandrdquo A D Khanolkar V Abadji S Lin W A G Hill G Taha K Abouzid Z Meng P Fan and A Makriyannis J Med Chem 39 pp4515-4519 (1996) httpdxdoiorg101021jm960152y

8 Substrate Specificity And Stereoselectivity Of Rat Brain Microsomal Anandamide Amidohydrolaserdquo Lang W C Qin S Lin AD Khanolkar A Goutopoulos P Fan K Abouzid Z

3

Meng D Biegel and A Makriyannis J Med Chem 42 pp 896-902 (1999)

httpdxdoiorg101021jm980461j

9 ldquoSynthesis and Evaluation for Potential Antihypertensive Activity of a Series of Substituted Imidazolinone Oximes and Cyclohexanespiro-8-imidazo[51-c]-124-oxdiazinesrdquo Mohamed Abdel Hamid Ismail Khaled Abouzid Awatef E Farag and Amani E Khalifa Alex J Pharm Sci 14(2) pp 151-161 (2000)

10 Synthesis and Antihypertensive Activity of Novel benzimidazole benzoxazole and benzothiazole derivatives Khaled Abouzid Hanan Refaat Maha Abdel Hakeem and Ashraf B Abdel-Naim Bull Fac Pharm Cairo Univ 40(1) pp 7-12 (2002)

11 ldquoSynthesis of Certain Substituted Quinoxalines as Antimicrobial Agents (Part I)rdquo Mohga M Badran Khaled A M Abouzid and M H M Hussein Az J Pharm Sci 30 57 (2002)

12 ldquoSynthesis of Certain Thienopyrimidine Derivatives as Antimicrobial Agentsrdquo A A Mouneer Khaled A M Abouzid and M M Said Az J Pharm Sci 30 150 (2002)

13 ldquoSynthesis of Certain 5678-tetrahydrobenzo[b]thienopyrimidines Fused with Various Heterocyclic Ring Systems as Potential Antihypertensive Agentsrdquo Mohamed Abdel Hamid Ismail Mohammed Nabil Y Aboul-Einein Khaled Abouzid Sahar Kandil Alex J Pharm Sci 15(2) 143 (2002)

14 ldquoSynthesis and Antimicrobial Activity of Certain Substituted Quinoxalines (Part II) rdquo Mohga M Badran Khaled A M Abouzid and and M H M Hussein Arch Pharm Res 26 2 pp 107-113 (2003) httpaprpskorkr

15 ldquoSynthesis and Antiinflammatory Activity of Novel Indazolonesrdquo Khaled A M Abouzid and H S El-Abhar Arch Pharm Res 26 1 pp 1-8 (2003) (Springer) httpaprpskorkr

16 ldquoSynthesis and Biological Evaluation of New Thiazololpyrimidinesrdquo Makarem Said Khaled A M Abouzid

Ashraf Mouneer Arch Pharm Res 27 pp 471-477 (2004) (Springer) httpaprpskorkr

17 ldquoAntipyretic Antinoceceptive and Anti-inflammatory Activity of Certain oxbutanoic Acid Derivativesrdquo Khaled AM Abouzid Khairia M Youssef Amany A E Ahmed and Hanna Hussain Al-Zuhair Med Chem Res 141 pp 26-39 (2005)

3

Meng D Biegel and A Makriyannis J Med Chem 42 pp 896-902 (1999)

httpdxdoiorg101021jm980461j

9 ldquoSynthesis and Evaluation for Potential Antihypertensive Activity of a Series of Substituted Imidazolinone Oximes and Cyclohexanespiro-8-imidazo[51-c]-124-oxdiazinesrdquo Mohamed Abdel Hamid Ismail Khaled Abouzid Awatef E Farag and Amani E Khalifa Alex J Pharm Sci 14(2) pp 151-161 (2000)

10 Synthesis and Antihypertensive Activity of Novel benzimidazole benzoxazole and benzothiazole derivatives Khaled Abouzid Hanan Refaat Maha Abdel Hakeem and Ashraf B Abdel-Naim Bull Fac Pharm Cairo Univ 40(1) pp 7-12 (2002)

11 ldquoSynthesis of Certain Substituted Quinoxalines as Antimicrobial Agents (Part I)rdquo Mohga M Badran Khaled A M Abouzid and M H M Hussein Az J Pharm Sci 30 57 (2002)

12 ldquoSynthesis of Certain Thienopyrimidine Derivatives as Antimicrobial Agentsrdquo A A Mouneer Khaled A M Abouzid and M M Said Az J Pharm Sci 30 150 (2002)

13 ldquoSynthesis of Certain 5678-tetrahydrobenzo[b]thienopyrimidines Fused with Various Heterocyclic Ring Systems as Potential Antihypertensive Agentsrdquo Mohamed Abdel Hamid Ismail Mohammed Nabil Y Aboul-Einein Khaled Abouzid Sahar Kandil Alex J Pharm Sci 15(2) 143 (2002)

14 ldquoSynthesis and Antimicrobial Activity of Certain Substituted Quinoxalines (Part II) rdquo Mohga M Badran Khaled A M Abouzid and and M H M Hussein Arch Pharm Res 26 2 pp 107-113 (2003) httpaprpskorkr

15 ldquoSynthesis and Antiinflammatory Activity of Novel Indazolonesrdquo Khaled A M Abouzid and H S El-Abhar Arch Pharm Res 26 1 pp 1-8 (2003) (Springer) httpaprpskorkr

16 ldquoSynthesis and Biological Evaluation of New Thiazololpyrimidinesrdquo Makarem Said Khaled A M Abouzid

Ashraf Mouneer Arch Pharm Res 27 pp 471-477 (2004) (Springer) httpaprpskorkr

17 ldquoAntipyretic Antinoceceptive and Anti-inflammatory Activity of Certain oxbutanoic Acid Derivativesrdquo Khaled AM Abouzid Khairia M Youssef Amany A E Ahmed and Hanna Hussain Al-Zuhair Med Chem Res 141 pp 26-39 (2005)

4

httpdxdoiorg101007s00044-004-0123-6

18 ldquoLigand Design and Synthesis of New Imidazo[51-b]quinazoline Derivatives as α1-Adrenoceptor Agonists and Antagonistsrdquo Mohamed A H Ismail Mohamed N Y Aboul-Enein Khaled A M Abouzid and Rabah A T Serya Journal of Bioorganic amp Medicinal Chemistry 14 pp 898-910 (2006) (Elsevier )httpdxdoiorg101016jbmc200507037

19 ldquoDesign and Synthesis of New Tetrazolyl and Carboxy-biphenyl methyl-quinazolin-4-one Derivatives as Angiotensin II AT1 Receptor Antagonistsrdquo Mohamed A H Ismail Stewart Baker Dalal A Abou El Ella Khaled Abouzid Rabab A Toubar and Matthew H Todd J Med Chem 49 pp 1526-1535 (2006) httpdxdoiorg101021jm050232e ISI Impact Factor 525

20 ldquoDesign Synthesis and Antihypertensive Activity of Certain Pyrazolopyrimidines with Arylpiperazine Side Chainsrdquo Khaled Abouzid Azza Taher Hanan H Kadry Bull Fac Pharm Cairo Univ 45(2) pp 87-97 (2007)

21 ldquoDesign Synthesis and Blood Pressure Lowering Activity of Certain Tetrahydrobenzo[b]thiophene Derivatives with

Arylpiperazinyl Side Chainsrdquo Khaled Abouzid Azza Taher Mona M Kamel Bull Fac Pharm Cairo Univ 45(2) pp 75-85 (2007)

22 ldquo6-Aryl-4-oxohexanoic Acids Synthesis Effects on Eicosanoid Biosynthesis and Anti-inflammatory in vivo -Activitiesrdquo Khaled Abouzid Petra Frohberg Jochen Lehmann and Michael Decker Medicinal Chemistry 3 pp 433-438 (2007) httpdxdoiorg102174157340607781745393

23 ldquoDesign Synthesis and in vitro Antitumor Activity of 4-Aminoquinoline and 4-Aminoquinazoline Derivatives Targeting EGFR Tyrosine Kinaserdquo Khaled Abouzid and Samia Shouman Bioorganic amp Medicinal Chemistry 16 7543ndash7551 (2008) (Elsevier ) httpdxdoi101016jbmc200807038

24 ldquoNovel Anti-Inflammatory Agents Based on Pyridazinone Scaffold Design Synthesis and in vivo Activityrdquo Khaled Abouzid and Salma A Bekhit Bioorganic amp Medicinal Chemistry 6 5547ndash5556 (2008) (Elsevier)

httpdxdoiorg101016jbmc200804007

25 ldquoPyridazinone Derivatives Design Synthesis and in vitro Vasorelaxant Activityrdquo Khaled Abouzid Maha Abdel Hakeem and Omnya Khalil Yosria Maklad Bioorganic amp Medicinal

5

Chemistry 16(1) pp 382-389 (2008) httpdxdoi101016jbmc200709031

26 Design synthesis and anti-inflammatory activity of 3-arylethenyl-6-substituted-pyridazines Khaled A M Abouzid Nadia A Khalil Eman M Ahmed Hekmat A Abd El-Latif Bull Fac Pharm Cairo Univ 46(3) pp 87-97 (2008)

27 ldquoLonazolac Analogues Molecular Modeling Synthesis and in vivo Anti-inflammatory Activityrdquo Mohamed A H Ismail Jochen

Lehmann Dalal A Abou El Ella Amgad Albohy and Khaled A M Abouzid Med Chem Res ( Springer) 18725-744 (2009) DOI 101007s00044-009-9163-2

28 ldquoACE inhibitors hypothesis generation for selective design synthesis and biological evaluation of 3-mercapto-2-methyl propanoylpyrrolidine-3-imine derivatives as antihypertensive agentsldquo Mohamed A H Ismail Mohamed N Y Aboul-Enein Khaled A M Abouzid Dalal A Abou El Ella and Naser Saad Bioorganic amp Medicinal Chemistry 17 3739ndash3746 (2009) (Elsevier)

DOI 101016jbmc200903008

29 Novel pyridine derivatives as anticancer agents and phosphodiesterase 3 inhibitorsrdquo Ashraf H Abadi Tamer M Ibrahim Khaled M Abouzid Jochen Lehmann Heather N Tinsley Bernard D Gary Gary A Piazza Bioorganic amp Medicinal Chemistry 17 (2009) 5974ndash5982 (Elsevier) doi101016jbmc20090606

30 Molecular Modeling Design Synthesis and Biological Evaluation of New Imidazoline Derivatives Linked as a1-AR Antagonists and AngII Receptor Antagonists Mohamed A H Ismail Dalal A R Abou El Ella Khaled A M Abouzid and Deena S M Lasheen Jordan Journal of Chemistry 4 (4) (2009) 329-347

31 Structure-Based Molecular Design Synthesis and in-vivo Anti-inflammatory Activity of Pyridazinone Derivatives as Non-Classic COX-2 Inhibitorsldquo Khaled A M Abouzid Nadia A Khalil Eman M Ahmed Hekmat A Abd El-Latif and Moustafa E El-Araby Med Chem Res 19 629-642 (2010) ( Springer) DOI 101007s00044-009-9218-4

32 Organic synthesis and biological evaluation of novel (3+1) mixed ligands of techntium-99m Gabapentin as receptor imaging agents A M Ami K Abou zid N A Bayoumi and M Abd El-hamid

6

J Radioanal Nucl Chem (2010) 28355ndash62

DOI 101007s10967-009-0059-x

33 Nitrat-Statin-Hybride eine neue Option zur Therapie der Alzheimerschen Krankheit Lengfelder Claudia Traber Heidi Roegler Carolin Khaled abuzid and Jochen Lehmann Herz

supplement (Munchen Print) 35 (2010) 12-17

34 Computer based drug design synthesis and biological evaluation of new pyrimidinone derivatives linked to arylpiperazine and 2-

carbethoxy-biphenylylmethyl moeities as 1-adrenoceptor antagonists and angiotensin II AT1 receptor antagonists Ismail M A H Abou El Ella D A Abouzid K A M Al-Ansary G H A

Pharmazie (2010) 65(11) 794-800 doi 101691ph20109732

35 Synthesis Binding Studies and Molecular Modeling of Novel Cannabinoid Receptor Ligands Noha A Osman Amr H Mahmoud Marco Allar Raimund Niess Khaled A Abouzid Vincenzo Di Marzo Ashraf H Abadi Bioorganic amp Medicinal Chemistry 18 (2010)

8463ndash8477 (Elsevier) doi101016jbmc20101005

36 Discovery of Novel Peptidomimetic Template for Hepatitis C Genotype 4

Inhibition Mohamed A H Ismail Dalal A Abou El Ella Eman M El labbad Waleed M El-Senousy and Khaled A M Abouzid Current Medicinal Chemistry (special issue abstracts for 3rd international Conference on Drug Discovery amp Therapy Feb 7-10 2011 Dubai UAE) pp 147 PO-149 (Bentham Science)

37 Molecular modeling study and synthesis of quinazolinone-

arylpiperazine derivatives as alfa1-adrenoreceptor antagonists Sahar

Mahmoud Abou-Seri Khaled Abouzid and Dalal A Abou El Ella

European Journal of Medicinal Chemistry 46 (2) 647-658 (2011)

(Elsevier)

doi101016jejmech201011045

38 Baclofen ester and carbamate prodrug candidates A simultaneous chromatographic assay resolution optimized with DryLab (Rasha Hanafia Salwa Mosada Khaled Abouzid Raimund Nieszlig Hilde Spahn-Langguth Journal of Pharmaceutical and Biomedical Analysis

56 (2011) 569ndash 576 (Elsevier) doi101016jjpba201106023

39 Synthesis and evaluation of antiproliferative activity of 14-disubstituted phthalazines Khaled A M Abouzid Nadia A Khalil and Eman M Ahmed Medicinal Chemistry Research 213288ndash3293

(2012) (Springer)

DOI 101007s00044-011-9874-z

40 Design synthesis and evaluation of anti-inflammatory and ulcerogenicity of novel pyridazinone derivatives K A M Abouzid N A Khalil E M Ahmed A Esmat and A M Al-Abd Medicinal Chemistry Research (2012) 213581-3590 (Springer)

7

DOI 101007s00044-011-9895-7

41 Preparation of 99mTc-Ceftazidime as a Model of Infection Imaging Agent M A Motaleb A A El-Mohty M A El Garhy Mohamed A H Ismail Khaled A M Abouzid and T M Sakr Arab Journal of Nuclear Sciences and Applications 44 (3) 57( 2011)

42 Labeling and Biological Evaluation of 99mTc-Cefotaxime for infective Inflammation Diagnosis M A Motaleb A A El-Mohty M A El Garhy Mohamed A H Ismail Khaled A M Abouzid and T M Sakr Arab Journal of Nuclear Sciences and Applications 44 67 ( 2011)

43 Synthesis and Binding Study of Certain 6-Arylalkanamides as

Molecular Probes for Cannabinoid Receptor Subtypes Azza T Taher Hanan H Kadry Marco AllaragraveVincenzo Di Marzo Ashraf H Abadi and Khaled A Abouzid Journal of Enzyme Inhibition and Medicinal

Chemistry 2013 Jun28(3)436-9 Informa) DOI 103109147563662011645241

44 Optimization of Benzoisothiazole dioxide inhibitory activity of the NS5B polymerase of HCV genotype 4 using ligand-steered homological modeling reaction-driven scaffold-hopping and E-novo workflow Amr Hamed Mahmoud Khaled Abouzid Mohamed Dalal Abd El Rahman Abou El Ella Mohamed Abdel Hamid Ismail Bioinformation 7(6) 328-333 (2011)

45 Integrated structure-based activity prediction model of benzothiadiazines against various genotypes of HCV NS5b polymerase (1a1b and 4) and its application in the discovery of new derivatives Mohamed AH Ismail Dalal A Abou El Ella Khaled AM Abouzid Amr H Mahmoud Bioorganic amp Medicinal Chemistry 20 (2012) 2455ndash2478

doi101016jbmc20120103 46 A Highly selective structure-based virtual screening model of Palm I

allosteric inhibitors of HCV Ns5b polymerase enzyme and its application

in the discovery and optimization of new analogues Amr H Mahmoud Dalal A Abou El Ella Mohamed AH Ismail Khaled AM Abouzid

European Journal of Medicinal Chemistry 57 2012 468-482

doi101016jejmech201204016 47 Synthesis and Anti-proliferative Activity of Substituted-

Anilinoquinazolines and Its Relation to EGFR Inhibition D A A El Ella

1 K A Saleh M Hassan N Hamdy M E El-Araby K A M

Abouzid Arzneimittelforschung 62(08) 360-366 (2012)

httpdxdoiorg 101055s-0032-1312601

48 Novel 2-thiopyrimidine derivatives as CDK2 inhibitors molecular

modeling synthesis and anti-tumor activity evaluation Omar Abd El-

Fattah M Fathalla Mohamed A H Ismail Manal M Anwar Khaled A

M Abouzid Aisha A K Ramadan Medicinal Chemistry Research 36(1)

41-5 April ( 2012)

DOI 101007s00044-012-0051-9 49 ldquoSubstitutedphthalazines and Phthalazinones Synthesis

Characterization and β- Adrenergic Blocking Activity Khaled A M

8

Abouzid Nadia Khalil and Eman M Ahmed Medicinal Chemistry

Research 22 Issue 3 (2013) 1057-1064

DOI 101007s00044-012-0099-6

50 Virtual screening and synthesis of new chemical scaffolds as VEGFR-2

kinase inhibitors Mohamed Saad Abdullah Elsayed Moustafa El-Sayed

El-Araby Rabah Ahmed Taha Serya and Khaled Abouzid

Arzneimittelforschung 2012 62 554ndash560 DOI101055s-0032-1323759 51 Structure-based design and synthesis of novel pseudosaccharine

derivatives as antiproliferative agents and kinase inhibitors Mohamed SA

Elsayed Moustafa E El-Araby Rabah AT Serya Ahmed H El-Khatib

Michael W Linscheid and Khaled A M Abouzid European Journal of Medicinal Chemistry vol 61 122-131 March (2013)

doi101016jejmech201209039

52 Design Synthesis and in vitro Anti-proliferative Activity of 46-

Quinazolinediamines as Potent EGFR-TK Inhibitors Samar Mowafy

Nahla A Farag Khaled A M Abouzid European Journal of Medicinal Chemistry vol 61 March 2013 132-145 (2013)

101016jejmech201210017

53 Ligand Design Synthesis and Biological Anti-HCV Evaluations for

Genotypes 1b amp 4a of Certain 4-3- amp 4-[3-(35-Dibromo-4-

hydroxyphenyl) propylamino] phenyl butyric acids and 3-(35-Dibromo-

4-hydroxyphenyl)-propylamino-acetamidobenzoic Acid Esters

Mohamed A H Ismail Khaled A M Abouzid Naser Saad and Eman M Elawady Dokla Journal of Enzyme Inhibition and Medicinal Chemistry Published online Oct 2012 DOI103109147563662012733384

54 3-[(6-Arylamino)pyridazinylamino]benzoic Acids Design Synthesis and in

vitro Evaluation of Anticancer Activity Khaled AM Abouzid Nadia A

Khalil Eman M Ahmed and Khaled Omar Mohamed accepted Arch Pharm Res (Springer) 3641ndash50 (2013) httpaprpskorkr

55 DESIGN SYNTHESIS AND VIRTUAL SCREENING OF CERTAIN 2-

PYRAZOLIN-5-ONE AND PYRAZOLIDINE-3 5-DIONE DERIVATIVES AS

POTENTIAL PPAR AGONISTS Mohamed A H Ismail Dalal A Abou El Ella Khaled A M Abouzid and Maiy Jaballah IJPSR 2012 Vol 3(10) 3746-3757

56 Molecular Design Synthesis and Cell Based HCV Replicon Assay of Novel

Benzoxazole Derivatives Mohamed A H Ismattil Mai Adel Nasser S M Ismail and Khaled A M Abouzid Drug Research 2013 63 109ndash120 DOI httpdxdoiorg101055s-0032-1331765

57 Synthesis and biological evaluation of new heteroaryl carboxylic acid

derivatives as anti-inflammatory-analgesic agents Khaled AM Abouzid Nadia A Khalil E M Ahmed and Sawsan A Zaitone Chemical Pharmaceutical Bulletin Japan 61 (2) 222-228 (2013)

9

58 Applying ligands profiling using multiple extended electron distribution based field templates and Feature trees similarity searching in the discovery of new generation of urea-based antineoplastic kinase inhibitors Eman M Dokla Amr H Mahmoud Mohamed S A Elsayed Ahmed H El-Khatib Michael W Linscheid Khaled A Abouzid PLOS ONE 2012 Vol 7 (11) e49284

wwwplosoneorg

59 Induced fit docking molecular dynamic simulation and QMMM scoring for

some new anti-HER2 compounds Marawan Ahmed Maiada M Sadek Rabah A Serrya Abdel-Hamid N Kafafy Khaled A Abouzid and Feng Wang Journal of Molecular Graphics and Modelling 40 2013 91-

98 doi101016jjmgm201212001

60 Discovery of new HER2EGFR dual kinase inhibitors based on the anilinoquinazoline scaffold as potential anti-cancer agents Maiada M Sadek Rabah A Serrya Abdel-Hamid N Kafafy Marawan Ahmed Feng Wang and Khaled A M Abouzid Journal of Enzyme Inhibition and Medicinal Chemistry Available online 12 February 2013 Apr29(2)215-22 (2014)

DOI 103109147563662013765417

61 Analogs Design Synthesis and Biological Evaluation of Peptidomimetics with Potential Anti-HCV Activity Deena S Lasheen Mohamed A H Ismail Dalal A Abou El Ella Nasser S M Ismail Sameh Eid Susan Vleck Jeffrey S Glenn Andrew G Watts Khaled A M Abouzid Bioorganic Medicinal Chemistry April (21) 2612-2755

2013 DOI 101016jbmc201303017

62 In Silico Design Extended Molecular Dynamic Simulations and Binding Energy Calculations for a New Series of Dually Acting Inhibitors against EGFR and HER2 Marawan Ahmed Maiada M Sadek Khaled A Abouzid Feng Wang Journal of Molecular Graphics

and Modelling July (44) 220-231 2013

httpdxdoiorg101016jjmgm201306004

63 Molecular Design and Synthesis of HCV Inhibitors Based on Thiazolone Scaffold Ghada H Al-Ansary Mohamed AH Ismail Dalal A Abou El Ella Sameh Eid Khaled AM Abouzid European Journal of Medicinal Chemistry October (68) 19-32 2013

httpdxdoiorg101016jejmech201307006

64 Molecular modelling and synthesis of quinazoline-based compounds as potential antiproliferative agents Asmaa S Yassen Hosam A El Shihawy Mohamed M Said and Khaled AM Abouzid Chem Pharm Bulletin (Japan) 62(5) 1-13 (2014)

65 Molecular design and synthesis of 14-disubstituted piperazines as α-adrenergic receptor blockers Dalal A Abou El-Ella Mohammed MHussein Rabah AT Serya Rana MAbdel Naby Ahmed MAl-Abd

10

Dalia O Saleh Wafaa I El-Eraky Khaled M Abouzid Bioorganic Chemistry (2014) 54 June 2014 Pages 21-30

doi httpdxdoiorg101016jbioorg201403005

Patents 1-New Targeted Therapy For Cancer Treatment Samar Mohamed Ahmed Mowafy and Khaled Abouzid Mohamed Abouzid 1371 appl date 2972012 Scientific Research Academy Cairo Egypt 2- Novel Curcumin analogs with anticancer activity PCTEG2013000028 appl date 17112013

11

Publication of Prof Dalal A Abou El Ella

Molecular design and synthesis of HCV inhibitors based on thiazolone scaffold Ghada H

Al-Ansary Mohamed A H Ismail Dalal A Abou El Ella Sameh Eid Khaled A M Abouzid

European journal of medicinal chemistry 072013 68C19-32 middot

6-Aryl and Heterocycle Quinazoline Derivatives as Potent EGFR Inhibitors with Improved

Activity toward Gefitinib-Sensitive and -Resistant Tumor Cell Lines Mostafa M Hamed

Dalal A Abou El Ella Adam B Keeton Gary A Piazza Ashraf H Abadi Rolf W Hartmann

Matthias Engel ChemMedChem 072013 middot

Analogs design synthesis and biological evaluation of peptidomimetics with potential anti-

HCV activity Deena S Lasheen Mohamed A H Ismail Dalal A Abou El Ella Nasser S M

Ismail Sameh Eid Susan Vleck Jeffrey S Glenn Andrew G Watts Khaled A M Abouzid

Bioorganic amp medicinal chemistry 032013 middot

Analogs design synthesis and biological evaluation of peptidomimetics with potential anti-

HCV activity Deena S Lasheen Mohamed AH Ismail Dalal A Abou El Ella Nasser SM

Ismail Sameh Eid Susan Vleck Jeffrey S Glenn Andrew G Watts Khaled AM Abouzid

Bioorganic amp Medicinal Chemistry 032013 2013 Mar 24

Quinazoline and tetrahydropyridothieno[23-d]-pyrimidine derivatives as irreversible EGFR

tyrosine kinase inhibitors influence of the position 4 substituent Mostafa M Hamed Dalal

A Abou El Ella Adam B Keeton Gary A Piazza Matthias Engel Rolf W Hartmann

Ashraf H Abadi Medicinal Chemistry Communication 012013 4(7)1202-1207

Synthesis and anti-proliferative activity of substituted-anilinoquinazolines and its relation to

EGFR inhibition D A A El Ella K A Saleh M Hassan N Hamdy M E El-Araby K A M

Abouzid Arzneimittel-Forschung 062012 62(8)360-6 middot

A highly selective structure-based virtual screening model of Palm I allosteric inhibitors of

HCV Ns5b polymerase enzyme and its application in the discovery and optimization of new

analogues Amr H Mahmoud Dalal A Abou El Ella Mohamed A H Ismail Khaled A M

Abouzid European journal of medicinal chemistry 042012

Integrated structure-based activity prediction model of benzothiadiazines on various

genotypes of HCV NS5b polymerase (1a 1b and 4) and its application in the discovery of

new derivatives

Mohamed A H Ismail Dalal A Abou El Ella Khaled A M Abouzid Amr H Mahmoud

Bioorganic amp medicinal chemistry 012012 20(7)2455-78

Molecular modeling study and synthesis of quinazolinone-arylpiperazine derivatives as α1-

adrenoreceptor antagonists Sahar Mahmoud Abou-Seri Khaled Abouzid Dalal A Abou El

Ella

11

Publication of Prof Dalal A Abou El Ella

Molecular design and synthesis of HCV inhibitors based on thiazolone scaffold Ghada H

Al-Ansary Mohamed A H Ismail Dalal A Abou El Ella Sameh Eid Khaled A M Abouzid

European journal of medicinal chemistry 072013 68C19-32 middot

6-Aryl and Heterocycle Quinazoline Derivatives as Potent EGFR Inhibitors with Improved

Activity toward Gefitinib-Sensitive and -Resistant Tumor Cell Lines Mostafa M Hamed

Dalal A Abou El Ella Adam B Keeton Gary A Piazza Ashraf H Abadi Rolf W Hartmann

Matthias Engel ChemMedChem 072013 middot

Analogs design synthesis and biological evaluation of peptidomimetics with potential anti-

HCV activity Deena S Lasheen Mohamed A H Ismail Dalal A Abou El Ella Nasser S M

Ismail Sameh Eid Susan Vleck Jeffrey S Glenn Andrew G Watts Khaled A M Abouzid

Bioorganic amp medicinal chemistry 032013 middot

Analogs design synthesis and biological evaluation of peptidomimetics with potential anti-

HCV activity Deena S Lasheen Mohamed AH Ismail Dalal A Abou El Ella Nasser SM

Ismail Sameh Eid Susan Vleck Jeffrey S Glenn Andrew G Watts Khaled AM Abouzid

Bioorganic amp Medicinal Chemistry 032013 2013 Mar 24

Quinazoline and tetrahydropyridothieno[23-d]-pyrimidine derivatives as irreversible EGFR

tyrosine kinase inhibitors influence of the position 4 substituent Mostafa M Hamed Dalal

A Abou El Ella Adam B Keeton Gary A Piazza Matthias Engel Rolf W Hartmann

Ashraf H Abadi Medicinal Chemistry Communication 012013 4(7)1202-1207

Synthesis and anti-proliferative activity of substituted-anilinoquinazolines and its relation to

EGFR inhibition D A A El Ella K A Saleh M Hassan N Hamdy M E El-Araby K A M

Abouzid Arzneimittel-Forschung 062012 62(8)360-6 middot

A highly selective structure-based virtual screening model of Palm I allosteric inhibitors of

HCV Ns5b polymerase enzyme and its application in the discovery and optimization of new

analogues Amr H Mahmoud Dalal A Abou El Ella Mohamed A H Ismail Khaled A M

Abouzid European journal of medicinal chemistry 042012

Integrated structure-based activity prediction model of benzothiadiazines on various

genotypes of HCV NS5b polymerase (1a 1b and 4) and its application in the discovery of

new derivatives

Mohamed A H Ismail Dalal A Abou El Ella Khaled A M Abouzid Amr H Mahmoud

Bioorganic amp medicinal chemistry 012012 20(7)2455-78

Molecular modeling study and synthesis of quinazolinone-arylpiperazine derivatives as α1-

adrenoreceptor antagonists Sahar Mahmoud Abou-Seri Khaled Abouzid Dalal A Abou El

Ella

12

European journal of medicinal chemistry 022011 46(2)647-58

New inhibitors of VEGFR-2 targeting the extracellular domain dimerization process

Mohammad Amin Elgamacy Raed Ahmed Shalaby Ahmad Tawfik Elkodsh Amr Fawzy

Kamel Mohamed Saad Abdullah Elsayed Dalal Abd El Rahman Abou-El-Ella

Bioinformation 012011 7(2)52-8

Optimization of Benzoisothiazole dioxide inhibitory activity of the NS5B polymerase of

HCV genotype 4 using ligand-steered homological modeling reaction-driven scaffold-

hopping and Enovo workflow Amr Hamed Mahmoud Khaled Abouzid Mohamed Abouzid

Dalal Abd El Rahman Abou El Ella Mohamed Abdel Hamid Ismail Bioinformation 012011

7(7)328-33

Computer--based drug design synthesis and biological evaluation of new pyrimidinone

derivatives linked to arylpiperazine and 2-carbethoxy-biphenylylmethyl moeities as alpha1-

adrenoceptor antagonists and angiotensin II AT1 receptor antagonists M A H Ismail D A

Abou El Ella K A M Abouzid G H A Al-Ansary Pharmazie 112010 65(11)794-800 middot

ChemInform Abstract Bridged Derivatives of Phenyl and Naphthylethylamine and Nitrogen

Analogous Compounds Part 5 Synthesis Structure and Pharmacological Effects of N3-

Substituted 12-Dihydrobenzo(f)quinolin-3-amines W WENDELIN J ZARFL E

GOESSNITZER D A EL ELLA ChemInform 012010 28(18)

Synthesis docking studies and anti-inflammatory activity of some 2-amino-5678-

tetrahydroquinoline-3-carbonitriles and related compounds

O I Abd El-Salam D A Abou El Ella N S M Ismail M Abdullah Pharmazie 042009

64(3)147-55

ACE inhibitors hypothesis generation for selective design synthesis and biological

evaluation of 3-mercapto-2-methyl-propanoyl-pyrrolidine-3-imine derivatives as

antihypertensive agents

Mohamed A H Ismail M Nabil Aboul-Enein Khaled A M Abouzid Dalal A Abou El Ella

Nasser S M Ismail

Bioorganic amp medicinal chemistry 042009 17(10)3739-46 middot 282 Impact Factor

Molecular Modeling Design Synthesis and Biological Evaluation ofNew Imidazoline

Derivatives Linked as α1-AR Antagonists and AngII Receptor Antagonists

Mohamed A H Ismail Dalal A R Abou El Ella Khaled A M Abouzid Deena S M

Jordan Journal of Chemistry 012009 4(4)329-347

ChemInform Abstract Synthesis Docking Studies and Antiinflammatory Activity of Some

2Amino5678-tetrahydroquinoline-3-carbonitriles and Related Compounds O I Abd El-

Salam D A Abou El Ella N S M Ismail M Abdullah ChemInform 012009 40(27)

Molecular modeling study and synthesis of novel pyrrolo[23-d]pyrimidines and

pyrrolotriazolopyrimidines of expected antitumor and radioprotective activities

13

Dalal A Abou El Ella Mostafa M Ghorab Eman Noaman Helmy I Heiba Amira I Khalil

Bioorganic amp medicinal chemistry 042008 16(5)2391-402 middot 282 Impact Factor

Computer-Based Ligand Design and Synthesis of Some New Sulfonamides Bearing Pyrrole

or Pyrrolopyrimidine Moieties Having Potential Antitumor and Radioprotective Activities

Mostafa M Ghorab Helmy I Heiba Amira I Khalil Dalal A Abou El Ella Eman Noaman

[show abstract]

Phosphorus Sulfur and Silicon and The Related Elements - PHOSPHOR SULFUR SILICON

012007 183(1)90-104

Design and synthesis of new tetrazolyl- and carboxy-biphenylylmethyl-quinazolin-4-one

derivatives as angiotensin II AT1 receptor antagonists

Mohamed A H Ismail Stewart Barker Dalal A Abou el-Ella Khaled A M Abouzid Rabab A

Toubar Matthew H Todd

Journal of Medicinal Chemistry 042006 49(5)1526-35 middot

Synthesis structural analysis and pharmacological effects of N2-substituted 34-

dihydrobenzo[h]quinolin-2-amines

W Wendelin H Keimelmayr E Goumlssnitzer D Abou el Ella

Pharmazie 121996 51(11)816-22

Synthesis of some new thiazolopyrane and thiazolopyranopyrimidine derivatives bearing a

sulfonamide moiety for evaluation as anticancer and radiosensitizing agents

Dalal A Abou El Ella Mostafa M Ghorab Helmy I Heiba Aiten M Soliman Medicinal

Chemistry Research Request full-text Bookmark

Lonazolac analogues molecular modeling synthesis and in vivo anti-inflammatory activity

Mohamed A H Ismail Jochen Lehmann Dalal A Abou El Ella Amgad Albohy Khaled A

M Abouzid Medicinal Chemistry Research 18(9)725-744

14

List of Publications of Dr Nasser S M Ismail (2007-2014)

Peer-reviewed articles

1 Computer based design synthesis and biological evaluation of novel indole derivatives

as HCV NS3-4A serine protease inhibitors N S M Ismail R S El Dine M Hattori

K Takahashi M Ihara Bioorg Med Chem 16 7877-7887 (2008)

2 ACE inhibitors hypothesis generation for selective design synthesis and biological

evaluation of 3-mercapto-2-methyl-propanoyl-pyrrolidine-3-imine derivatives as

antihypertensive agents M A H Ismail M N Aboul-Enein K A M Abouzid D A

Abou El Ella N S M Ismail Bioorg Med Chem 17 3739-3746 (2009)

3 Synthesis docking studies and anti-inflammatory activity of some 2-amino-5678-

tetrahydroquinoline-3-carbonitriles and related compounds O I Abd El-Salam D A

Abou El Ella N S M Ismail M Abdullah Pharmazie 64 147-155 (2009)

4 A convenient synthesis and molecular modeling study of novel purine and pyrimidine

derivatives as CDK2cyclin A3 inhibitors A S H Elgazwy N S M Ismail H S A

Elzahabi Bioorg Med Chem 18 7639-7650 (2010)

5 Regioselective synthesis and molecular modeling study of vasorelaxant active 79-

dioxa-12-diaza-spiro[45]dec-2-ene-610-diones A S Girgis N S M Ismail H

Farag W I El-Eraky D O Saleh S R Tala A R Katritzky Eur J Med Chem 45

4229-4238 (2010)

6 Discovery of novel benzo[a]phenoxazine SSJ-183 as a drug candidate for malaria J F

Ge C Arai M Yang M Abu Bakar J Lu N S M Ismail S Wittlin M Kaiser R

Brun S A Charman T Nguyen J Morizzi I Itoh M Ihara ACS Medicinal

Chemistry Letter 1 360-364 (2010)

7 Computer aided design synthesis and biological evaluation of novel acridine

derivatives as topoisomerase I Inhibitors G M El Taliawi1 E I Ali G Hegazy N S

M Ismail W Ramadan J American Science 6 11 (2010)

8 Molecular modeling based approach synthesis and in vitro assay to new indole

inhibitors of hepatitis C NS34A serine protease N S M Ismail M Hattori Bioorg

Med Chem 19 374-383 (2011)

9 Facile synthesis vasorelaxant properties and molecular modeling studies of 2-amino-

8a-methoxy-4H-pyrano[32-c]pyridine-3-carbonitriles A S Girgis N S M Ismail H

Farag Eur J Med Chem 46 2397-2407 (2011)

15

10 Synthesis hypnotic properties and molecular modeling studies of 1279-tetraaza-

spiro[45]dec-2-ene-6810-triones A S Girgis H Farag N S M Ismail R F

George Eur J Med Chem 46 4964-4969 (2011)

11 Design synthesis and biological study of novel pyrido[23-d]pyrimidine as

antiproliferative CDK2 inhibitors A I Diaa N S M Ismail Eur J Med Chem 46

5825-5832 (2011)

12 Synthesis and QSAR study of novel cytotoxic spiro[3H-indole-32(1H)-pyrrolo[34-

c]pyrrole]-235(1H2aH4H)-triones A S Girgis J Stawinski N S M Ismail H

Farag Eur J Med Chem 47 312-322 (2012)

13 Palladacycles as antimicrobial agents AS S H Elgazwy N S M Ismail S R Atta-

Allah M T Sarg D H S Soliman M Y Zaki M A Elgamas Current Med Chem

19 3967-3981 (2012)

14 Dopamine D2 receptor antagonist activity and molecular modeling of certain new

cyclohexane derived arylcarboxamides structurally related tometoclopramide M N

Aboul-Enein A A EL-Azzouny M I Attia Y A Maklad M A Ismail N S M

Ismail W H A Abdel-Hamid Digest J Nanomaterials and Biostructures 7 537-553

(2012)

16 Molecular design synthesis and cell based HCV replicon assay of novel benzoxazole

derivatives M A H Ismail M Adel N S M Ismail K A M Abouzid Drug

Research 63 109-120 (2013)

17 Ligand design synthesis and biological anti-HCV evaluations for genotypes 1b and 4a

of certain 4-(3- amp 4-[3-(35-dibromo- 4-hydroxyphenyl)-propylamino]phenyl) butyric

acids and 3-(35-dibromo-4-hydroxyphenyl)-propylaminoacetamidobenzoic acid esters

M A Ismail K A M Abouzid N S M Ismail E M E Dokla J Enzyme Inhibition

and Med Chem 28 6 1274-1290 (2013)

18 Molecular modeling study bioactive natural product of khellin analogues as a novel

potential pharmacophore of EGFR inhibitors A S H Elgazwy M M Edrees N S M

Ismail J Enzyme Inhibition and Med Chem 28(6)1171-81(2013)

19 Analogs design synthesis and biological evaluation of peptidomimetics with potential

anti-HCV activity M A H Ismail D S Lashin N S M Ismail K A M Abouzid

Bioorg Med Chem 21 2742ndash2755 (2013)

20 Design synthesis and QSAR studies of dispiroindole derivatives as new

16

antiproliferative agents R F George N S M Ismail J Stawinski A S Girgis Eur

J Med Chem 68 339-351 (2013)

21 Design and synthesis of certain substituted cycloalkanecarboxamides structurally related

to safinamide with anticonvulsant potential M N Aboul-Enein A A El-Azzouny Y

A Maklad M A Ismail N S M Ismail R M Hassan Research on Chemical

Intermediates DOI 101007s11164-013-1488-2 (in press)

2 Patents (indicate registration date)

Ge J F Arai C Yang M Ismail N S M Brun R Itoh I Ihara M Medicinal

composition containing benzo[A]phenoxazine compound as the active ingredient for

preventing or treating protozoal disease Japanese Patent Application PCT JP2009054634

(Hoshi University Tokyo) PCT (International Patent)17 September 2009 WO

2009113569 A1

15

10 Synthesis hypnotic properties and molecular modeling studies of 1279-tetraaza-

spiro[45]dec-2-ene-6810-triones A S Girgis H Farag N S M Ismail R F

George Eur J Med Chem 46 4964-4969 (2011)

11 Design synthesis and biological study of novel pyrido[23-d]pyrimidine as

antiproliferative CDK2 inhibitors A I Diaa N S M Ismail Eur J Med Chem 46

5825-5832 (2011)

12 Synthesis and QSAR study of novel cytotoxic spiro[3H-indole-32(1H)-pyrrolo[34-

c]pyrrole]-235(1H2aH4H)-triones A S Girgis J Stawinski N S M Ismail H

Farag Eur J Med Chem 47 312-322 (2012)

13 Palladacycles as antimicrobial agents AS S H Elgazwy N S M Ismail S R Atta-

Allah M T Sarg D H S Soliman M Y Zaki M A Elgamas Current Med Chem

19 3967-3981 (2012)

14 Dopamine D2 receptor antagonist activity and molecular modeling of certain new

cyclohexane derived arylcarboxamides structurally related tometoclopramide M N

Aboul-Enein A A EL-Azzouny M I Attia Y A Maklad M A Ismail N S M

Ismail W H A Abdel-Hamid Digest J Nanomaterials and Biostructures 7 537-553

(2012)

16 Molecular design synthesis and cell based HCV replicon assay of novel benzoxazole

derivatives M A H Ismail M Adel N S M Ismail K A M Abouzid Drug

Research 63 109-120 (2013)

17 Ligand design synthesis and biological anti-HCV evaluations for genotypes 1b and 4a

of certain 4-(3- amp 4-[3-(35-dibromo- 4-hydroxyphenyl)-propylamino]phenyl) butyric

acids and 3-(35-dibromo-4-hydroxyphenyl)-propylaminoacetamidobenzoic acid esters

M A Ismail K A M Abouzid N S M Ismail E M E Dokla J Enzyme Inhibition

and Med Chem 28 6 1274-1290 (2013)

18 Molecular modeling study bioactive natural product of khellin analogues as a novel

potential pharmacophore of EGFR inhibitors A S H Elgazwy M M Edrees N S M

Ismail J Enzyme Inhibition and Med Chem 28(6)1171-81(2013)

19 Analogs design synthesis and biological evaluation of peptidomimetics with potential

anti-HCV activity M A H Ismail D S Lashin N S M Ismail K A M Abouzid

Bioorg Med Chem 21 2742ndash2755 (2013)

20 Design synthesis and QSAR studies of dispiroindole derivatives as new

16

antiproliferative agents R F George N S M Ismail J Stawinski A S Girgis Eur

J Med Chem 68 339-351 (2013)

21 Design and synthesis of certain substituted cycloalkanecarboxamides structurally related

to safinamide with anticonvulsant potential M N Aboul-Enein A A El-Azzouny Y

A Maklad M A Ismail N S M Ismail R M Hassan Research on Chemical

Intermediates DOI 101007s11164-013-1488-2 (in press)

2 Patents (indicate registration date)

Ge J F Arai C Yang M Ismail N S M Brun R Itoh I Ihara M Medicinal

composition containing benzo[A]phenoxazine compound as the active ingredient for

preventing or treating protozoal disease Japanese Patent Application PCT JP2009054634

(Hoshi University Tokyo) PCT (International Patent)17 September 2009 WO

2009113569 A1

16

antiproliferative agents R F George N S M Ismail J Stawinski A S Girgis Eur

J Med Chem 68 339-351 (2013)

21 Design and synthesis of certain substituted cycloalkanecarboxamides structurally related

to safinamide with anticonvulsant potential M N Aboul-Enein A A El-Azzouny Y

A Maklad M A Ismail N S M Ismail R M Hassan Research on Chemical

Intermediates DOI 101007s11164-013-1488-2 (in press)

2 Patents (indicate registration date)

Ge J F Arai C Yang M Ismail N S M Brun R Itoh I Ihara M Medicinal

composition containing benzo[A]phenoxazine compound as the active ingredient for

preventing or treating protozoal disease Japanese Patent Application PCT JP2009054634

(Hoshi University Tokyo) PCT (International Patent)17 September 2009 WO

2009113569 A1