DEPARTMENT OF BIOSTATISTICS Biostatistics Resource and Training Centre Advanced Clinical Data Management Centre Christian Medical College, Vellore - 632 002, India.

Dr. L. JEYASEELAN, Ph.D., F.R.S.S.,F.S.M.S., Professor and Head Course Coordinator

March 29, 2018

Dear Friends,

Greetings from Vellore. The Biostatistics Resource and Training Center, Department of Biostatistics at Christian Medical College, Vellore is glad to announce the commencement of thirty-seventh Short course in Biostatistics. The course is scheduled from May 28 – June 07, 2018.

The course is mainly designed to train researchers of varied profession and statisticians to competently handle health/medical data and be in a better position to function effectively in a research team.

Christian Medical College has conducted series of workshops in collaboration with faculty from McMaster University, Canada and University of North Carolina, Chapel Hill, USA since 1996. The course materials of those workshops are incorporated in this program.

The current Courses is:

Course Date Last Date

Multiple Linear Regression, Logistic Regression & Survival Analysis May 28-June 01, 2018 May 21, 2018

Multilevel Modeling (MLM) and Longitudinal / Repeated Measure data analyses using Linear Models & Generalized Estimating Equations (GEE)

June 04 - 07, 2018 May 28, 2018

The number of participants for each course is limited to 45, and admission will be purely on first come first served basis. Attached herewith and brochure and registration form and also it can be downloaded from our website: www.cmc-biostatistics.ac.in I will be very happy to provide more information, if necessary.

Looking forward to hearing from you.

Sincerely,

Dr. L. Jeyaseelan Course Coordinator

Telephone: 91 416 2284205, 2262703 Fax No: 91-416-2262703 E-mail: biostats@cmcvellore.ac.in Website: www.cmc-biostatistics.ac.in

Course Fee : Rs. 5,000/-

Multiple Linear Regression, Logistic Regression & Survival Analysis

May 28 - June 01, 2018 Venue: Biostatistics Resource and Training Center (BRTC),

Department of Biostatistics, (Adjacent to College Chapel),

Christian Medical College, Bagayam, Vellore 632 002.

This course is intended to improve participant's ability to conduct regression analyses and

study the relationship between response variable and multiple predictor variables. This

course is also intended to sharpen the skills of analyzing binary outcome data and

interpreting regression coefficients.

This course is targeted towards epidemiologist, biostatisticians, Demographers and other

medical researchers.

Participants will have to bear their own expenses for travel, boarding and lodging. The

Organizers will provide Course kit, Lunch and Snacks. However, the organizers may

arrange basic accommodation with A/C facility in the college campus on request. Only

limited accommodation is available in the campus and priority will be given to the female

participants.

Course Fee should be paid in full by May 21, 2018.

Payment can be made by Demand Draft in favor of “Christian Medical College

Vellore Association Account”, payable at Vellore.

The cost of the nMaster software is fixed for Rs.2500/- for Academic / Government

institutions and Rs.5000/- for Commercial. However, those who would participate in

this workshop from the Academic / Government institutions, a concession price is

Rs.1500/- and Commercial is Rs.4000/-.

Please use the attached “Application Format” for registration to be sent, along with the

required Demand Draft (DD).

Note: After Registration if cancelled the course fee will not be refunded. The number of

participants for each course is limited to 45 and admission will be purely on first come

first served basis.

Course Content

Regression Analysis

Introduction to Regression

Simple Linear Regression

Assumptions

Tests of Slop and intercept

Multiple Linear Regression

Model Building strategy

Assessing Best Fit

Multicollinearity Problem and Diagnostics

Logistic Regression

Introduction to Logistic Regression, Rationale

Single & Multiple Logistic Regressions

Creating dummy variables

Model Building

Assessing Best Fit

Diagnostics

Matched Data Analysis

Ordinal response logistic regression

Survival Analysis

Introd. to Survival Analysis

Kaplan Meier Survival Curves

Comparison of two Survival Curves

Cox Proportional Hazards Model

Proportional Hazards Assumption (Graphical Approach and Goodness of Fit)

Statistical Software: SPSS & STATA (Analyses)

Course Fee : RS. 7,670/- (Inclusive of 18% GST)

nMaster 2.0 (Sample Size calculation software - Developed by Dr.L.Jeyaseelan and Team)

Short Course in Biostatistics

Accommodation

HOW TO APPLY

www.cmc-biostatistics.ac.in

Course Coordinator Secretariat / Contact person Dr. L. Jeyaseelan, Mr. C. Jayaprakash / Mr. Shankar

Professor and Head Email: biostats@cmcvellore.ac.in

Biostatistics Resource and Training Centre (BRTC) Phone: (0416) 2262703, 2284205

Advanced Clinical Data Management Centre (ACDMC)

Department of Biostatistics, Christian Medical College, Bagayam, Vellore 632 002. India.

Faculty

Dr. L. Jeyaseelan Professor

Course Fee : Rs. 5,000/-

Repeated measures: In medical research repeated measures (Longitudinal) data analyses are very common. Diabetes patients are followed periodically over time (every 6 month for example two years) to study the impact of treatment in HbA1c level. The usual regression analyses assumes that the repeated measure data is independent, while they are dependent (correlated) in nature. or the observations within an individual are correlated. Assuming independence while the observations are correlated would provide a narrow CI for the regression coefficients thus paving the way for highly significant results. Therefore the right analyses would be to capture the amount of correlation within the individual level and adjust that correlation in the regression analyses. This procedure is cal led Generalized Estimating Equation (GEE).

Multilevel models are basically regression models of data that have a hierarchical or clustered structure. Such kind of data arises routinely in many fields, for instance in growth studies (where students are nested within class rooms and class rooms are nested within schools. Thus the first level is class room and the higher level is school), family studies (with children nested within families), and in medical research (with patients nested within physicians or hospitals). Clustered data may also arise based on specific research design. For example, in large scale survey research the data collection is usually organised in some sort of multistage sampling design that results in clustered design. Hierarchical linear models, Random coefficient models, Variance component models or multilevel random coefficient models are other names for the multilevel models. Repeated measures analyses is a single level MLM.

Practicals and Software: Practical will be followed by a lecture and real time data will be used for practicals. Practicals will be taught using SPSS, MLWIN (copy will be provided) and STATA.

Who should attend: Biostatisticians/ Statisticians, Epidemiologists, Medical Researchers and Social Scientists who have basic knowledge in Regression analyses.

Participants will have to bear their own expenses for travel, boarding and lodging. The Organizers will provide Course kit, Lunch and Snacks. However, the organizers may arrange basic accommodation with A/C facility in the college campus on request. Only limited accommodation is available in the campus and priority will be given to the female participants.

Course Fee should be paid in full by May 28, 2018. Payment can be made by Demand Draft in favor of “Christian Medical College Vellore Association Account”, payable at Vellore. Please use the attached “Application Format” for registration to be sent, along with the required Demand Draft (DD). Note: After Registration if cancelled the course fee will not be refunded. The number of participants for each course is limited to 45 and admission will be purely on first come first served basis.

Course Content

Multilevel Modeling (MLM)

Multi-stage sampling and multilevel

theories : Macro, micro level units and

cross-level relations

Statistical treatment of clustered data :

Aggregation, disaggregation, Intra-cluster

correlation coefficient (ICC), design effect

in two stage sampling

The random intercept model : Definition,

within and between group regressions,

simple and multiple regression models

The random slope model: Introduction,

analyses and interpretation, explanation

of random intercept and slope

Generalized Estimating Equations (GEE)

Introduction to longitudinal data:

Traditional methods: Repeated measures

Analysis of Variance, summary measures

and relationship with other variables

Generalized estimating equations-The

best approach: Introduction, working

correlation structures, GEE for continuous

and categorical outcome, interpretation

and diagnostics (QIC)

MLM versus GEE: Comparison between

random coefficients and GEE

Statistical Software: SPSS, MlWin &

STATA

Course Fee : RS. 6,490/- (Inclusive of 18% GST)

Short Course in Biostatistics

Accommodation

HOW TO APPLY

Course Coordinator & Faculty Secretariat / Contact person Dr. L. Jeyaseelan, Mr. C. Jayaprakash / Mr. Sankar

Professor and Head Email: biostats@cmcvellore.ac.in

Phone: (0416) 2262703, 2284205

Multilevel Modeling (MLM) and Longitudinal / Repeated Measure data analyses using Generalized Estimating Equations (GEE) June 04 - 07, 2018 Venue: Biostatistics Resource and Training Center (BRTC), Department of Biostatistics, (Adjacent to College Chapel), Christian Medical College, Bagayam, Vellore 632 002.

Faculty

Dr. L. Jeyaseelan Professor

www.cmc-biostatistics.ac.in

NAME IN CAPITAL : D R / M R / M S / M R S _______________________________________

(FOR CERTIFICATE PURPOSE)

AGE : ______ SEX : M / F

EDUCATIONAL BACKGROUND :________________________________________________________

DESIGNATION : ________________________________________________________

DEPARTMENT :________________________________________________________

INSTITUTION :________________________________________________________

ADDRESS :________________________________________________________

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STATE : ________________________________________________________

PHONE & MOBILE : ________________________________________________________

PERSONAL EMAIL : ________________________________________________________

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ACCOMMODATION : REQUIRED / NOT REQUIRED

(PRIORITY WILL BE GIVEN TO THE FEMALE PARTICIPANTS)

IF REQUIRED, TENTATIVE DATE & TIME: ARRIVAL _________________________________________

DEPARTURE _______________________________________

COURSES OPTED FOR : (PLEASE ENCIRCLE)

1. MULTIPLE LINEAR REGRESSION, LOGISTIC REGRESSION & SURVIVAL ANALYSIS (RS. 7,670)

2. MULTILEVEL MODELING (MLM) AND LONGITUDINAL / REPEATED MEASURE DATA ANALYSES USING LINEAR

MODELS & GENERALIZED ESTIMATING EQUATIONS (GEE) (RS. 6,490)

DD AMOUNT : RS. ____________ DATE : ____________

DD NUMBER : _______________ BANK : __________________________

NOTE: AFTER REGISTRATION IF CANCELLED THE COURSE FEE WILL NOT BE REFUNDED

Department of Biostatistics, CMC, Vellore-2

SHORT COURSE IN BIOSTATISTICS MAY 28 – JUNE 07, 2018

REGISTRATION FORM

SIGNATURE

List of Hotels available in Vellore

Vellore city STD code is +91- 416

Hotel name Single

non AC

Double

non AC

Single

AC

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Distance

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Note: Rates may be subject to revision