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DENTAL PROBLEMS DELAYING THEINITIATION OF INTERFERON THERAPY FOR

HCV-INFECTED PATIENTSYUMIKO NAGAO, MICHIO SATA

NAGAO AND SATA VIROLOGY JOURNAL 2010, 7:192HTTP://WWW.VIROLOGYJ.COM/CONTENT/7/1/192

Oleh :Isni Puji Lestari1007101230008

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INTRODUCTION

Interferon (IFN )therapy for chronic hepatitis C isthe

only treatment for chronic hepatitis C

Combination therapy with pegylated IFN (Peg-

IFN) and ribavirin has been recommendedwidely as the first choice for chronic hepatitis Cpatients with high viral loads

Side effects from therapy are fatigue, influenza-like syndrome and neuropsychiatric symptoms

it has been reported that hepatitis C infectedpatients have significant oral health needs

dental caries is significantly worse for HCV-infected patients than patients in general

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OBJECTIVES

To determine whetherdental problem

delayed the initiation

of IFN therapy forHCV-infected patient

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METHODS

570 HCV-infected patienttreat with Peg-IFN

monotherapy or Peg-IFN/ribavirin combination

therapy required to

undergo hospitalization fortwo weeks

Xerostomia detection,which requires chewing ona piece of gauze for 2 min

Serum samples wereexamined for the presenceor absence of markers ofHCV and HBV infection,analyzed by quantitative

PCR assay

PATIENT

SALIVARY

FLOW

SEROLOGICAL ASSAYS

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RESULT

From 570 patients with HCV-related liverdiseases, documented six whose dentalproblems delayed the initiation of Peg-IFNtherapy ages ranged from 25 to 67 years.

Dental problem found that delayed initiation ofIFN therapy : periapical periodontitis acute alveolar abcess

periodontal disease pulpitis wisdom tooth

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...CONT RESULT

All dental problem has been treatedsuccesfully and after that received IFNtreatment was completed.

The outcome of the patient have HCV RNAnegative for six month or more aftertreatment.

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DISCUSSION

The results indicate that oral health care may be required before HCV-infectedpatients undergo IFN therapy.

In a Japanese Phase III trial of Peg-IFN, 100 patients after IFN therapy still havethe HCV RNA with the oral side effects: gingival bleeding and gingival swelling (6%), Toothache (4.5%), gingivitis and periodontitis (3%), dental caries (1.5%), stomatitis and cheilitis (19.1%), disorder of taste (15.6%), dry mouth (6.5%), glossalgia and glossitis (4.5%), perioral paresthesia (2.5%), oral pain (0.5%), Oral mucosal damage (0.5%), oral lichen planus (0.5%), Oral hemorrhage (0.5%), dry lip (0.5%), and bulla of lip (0.5%).

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...CONT DISCUSSION

These findings indicate that dentalmanagement of HCV-infected patients isrequired before IFN therapy

health education is also required for HCV-infected patients and dental practitioners formaintanance the oral hygiene to lessen the

oral side effect

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CONCLUSION

the results of this study show that thetreatment of dental infection is requiredbefore IFN therapy for HCV infection

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THANK YOU