dennis l. molfese, ph.d. mildred francis thompson professor director: center for brain, biology...
TRANSCRIPT
Dennis L. Molfese, Ph.D.Mildred Francis Thompson Professor
Director: Center for Brain, Biology & BehaviorDirector: Big Ten/CIC Traumatic Brain Injury Research Consortium
Editor-In-Chief: Developmental NeuropsychologyDirector: Developmental Neuroscience Lab
University of Nebraska -Lincoln
Interdisciplinary Research Center
Center for Brain, Biology, & Behavior
Acknowledgements
–Cathryn Cortesa, BA
–Nicole Earnest
–Caitlin Hudac, MA
–Kathleen Kelsey, MA
–Srinivas Kota, Ph.D.
–Christopher Rudasill, MFA
–Nathan Petro, B.A.
–Victoria Molfese, Ph.D.
Philosophy of The Center
• Foster Interdisciplinary Collaborations. • Provide Assess to BOTH Equipment & Training.• Lead Paradigm Shift Within The Neurosciences:
–- Move from “neural phrenology” to Understanding Brain’s Neural Spatial & Temporal Interconnectivty.–- Address Characteristics of Processing In and Between Brain Regions.
New Stadium Additions
Center for Brain, Biology, & Behavior Health & Performance
Research Lab
Athletics/Academics Collaboration: An Unprecedented Initiative
• Informs:
–Medical & Behavioral Science
–Athletic & Academic Training & Competition
–Safety
–Innovations
• Consortium of 13 University Research & Sport Programs with BIG 10 CIC + 8 Ivy League Schools
• Coaches
• Trainers
• Behavior & Brain Imaging Researchers
• Shared data base for images, behavior data, test procedures & programs
• Increasing external grant funding.
BIG 10 - Ivy League Concussion Research Collaboration
Unprecedented New Information
• Screen Athletes Before Season (baseline)
• Track Performance, Neurocognition & Brain Measures
•Head Injured & Matched Controls
•Assess Impact of Multiple Concussion
•Shared Database Across Conferences
• Design Interventions
• Improve Equipment Design
• Develop Concussion Awareness Programs
Facilities
1st Floor
2nd FloorReception
2nd Floor
Internal Stairway Connecting 2nd and 3rd Floors
3rd Floor
Science Work Group Areas for 2nd and 3rd Floors
Training Plan
Model for Training in Brain Imaging Techniques
1. Workshop Introduction to Theory, Methods, Literature, Analyses (2-days)
2. Consult on research design3. Hands-on training with equipment for
setup, data collection, data processing & analysis.4. Assistance with:
a. Data analysesb. Conference presentationsc. Journal article drafts
5. Grant submissionsGOAL: Establish Dominance in Mainstream Research Areas Through Research & Grant Activities.
CB3 Training To DateOctober 1, 2010 - August, 2012
• 8 Two-Day Workshop: 227 Faculty & Students
• Advanced Imaging Training: 69 Faculty & Students
• Current Research Studies: 12 Projects
• Department Presentations: 38
Current Trainees = 2608-22-2012
Available TechnologiesfMRI
High Density Infant & Adult NIRSHigh-Density EEG/ERP
Transcranial Magnetic Stimulation -TMSBehavior Science Labs
Balance LabsComputer Labs
Developmental LabsEndocrine Lab
Eye Tracking LabsGenetics Lab
Political Science Lab
fMRI - functional Magnetic Resonance Imaging
Siemens 3 Tesla70 cm bore
Structure
Function
DTI
fMRI - functional Magnetic Resonance Imaging
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Diffusion Tensor Imaging
Magnetic Resonance Spectroscopy
fMRI Imaging
Attachment
Dyslexia
Balance Lab
Gait Testing
Videonystagmography (VNG)
Rotational Chair
Subjective Visual Vertical
Functional Evaluation of Vestibulo-Ocular Reflex (VOR)
Balance Function Testing
NIRS - Near-Infrared Spectroscopy
TMS - Transcranial Magnetic Stimulation Machine
High-Density ERP/EEG
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Event-Related Potentials (ERP)
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Newborn Infant Adult
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Front of Head
Left Side Right Side
Back of Head
NEWBORN
+
-
Front of Head
Left Side Right Side
Back of Head
Adult
+
-
Learning alters brain organization for acquisition of new information
Shape Matching Task
Different
Same
Molfese et al, 2008
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Low GRTR[GRTR less than 11]
High GRTR[GRTR more than 11]
Eye Tracker
Eye Tracker + ERP net Eye Tracking Information
Intervention
Ability to discriminate /da/ from /ga/
ERPs in 2 to 4-Year-Old Preschool SLI Children Predict Subsequent Language Gains Following 4 Month Intervention
Yoder, Molfese & Camarata, In Press
Training Task Results
Training TaskTraining Task
Additional Benefits
Concussion Intervention
Concussion
Issues in Assessing Sports Concussion• 1. Little information on brain & behavior prior to
concussion.
• 2. Little long-term follow-up following concussion using standardized testing.
• 3. Tests not comprehensive (e.g., ImPACT not effective in measuring attention, working memory).
• 4. Little information available regarding prior head injuries.
• 5. Falsification of pre-season tests by athletes.
• 6. Pressure to resume play following possible head injury.
• 7. No research-based information regarding when players can be safely returned to play.
Brain Deformation Following Side “Hit”
Pellman et al., 2006
Top View
Side View <__Directionof
Force
<__Directio
nof
Force
Brain Deformation Following Side “Hit”
Pellman et al., 2006
Top View
Side View <__Directionof
Force
<__Directio
nof
Force
Force canproduceshearing
Vestibular Tests May Help to Identify and Manage Concussion
Julie Honaker, Ph.D.
Working Memory: 2-back
N400N400
N2N2
Match Nonmatch
Match Nonmatch
Sports Concussion
Self-reported symptoms & N2
N2N2
Mat
chN
onm
atch
2.5 nA
.01 nA
No history of persistent headache (n=16)
History of persistent headache (n=19)
Normal Visual World
World at an Angle
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20-40% with TBI experience vision-disorders
Hudac et al, 2011
Post-Trauma Vision SyndromeVisual Midline Shift Syndrome
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Future Possibilities
• Use brain imaging procedures to identify distortions produced by brain injury.
• Identify intervention that can produce more normal neural processing.
• Use the successful intervention to enable individual to perceive and interact with the world in more normal fashion.
©2012 The Board of Regents of the University of Nebraska. All rights reserved.
Questions ???
fMRI - functional Magnetic Resonance Imaging
High-Density ERP/EEG: Newborn Infant
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Event-Related Potentials (ERP)
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High-Density ERP/EEG: Adult
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fMRI
DTI
Structure
Function
TracksBlood Flow inBrain
ERP
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Key et al., In press