day 1. june 07, 2016. tuesday big hall 9.00 musical...

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DAY 1. June 07, 2016. Tuesday BIG HALL 9.00 Musical greeting 9.30 Opening of the XXIX International Congress with Endoscopic Course “New Technologies for Diagnosis and Treatment of Gynecologic Diseases” x Greeting from the Ministry of Health of the Russian Federation Chairman of the Congress Organizing Committee, Director of the Research Center for Obstetrics, Gynecology and Perinatology, Academician of RAS, professor Sukhikh G.T. x President of the Congress, Deputy Director of the Research Center for Obstetrics, Gynecology and Perinatology, Head Specialist in Obstetrics and Gynecology of the Ministry of Health of Russia, Academician of RAS, professor L.V.Adamyan 10.50 Problematic lecture Assisted reproductive technologies and their impact both positive and negative on obstetrics V. Senikas, Ottawa, Canada Plenary Session I ENDOMETRIOSIS ONE OF THE KEY PROBLEMS IN GYNECOLOGY Chairmen G.T. Sukhich, O.S. Philippov, L.V. Adamyan, E.L Ailamazyan, G.M. Savelieva, A.N. Strizhakov, V.N. Serov, V.I. Krasnopolsky, L.A. Ashrafyan, M.A. Kurtser, A.D. Makatsaria, I.S. Sidorova, Ph. Koninckx, A. Ebert, Ch. Köhler, Y.Ota, A. Setúbal, I.Ota, А.Ussia, W. Pauker, H.Soleymani 10.30 Challenges in the treatment of endometriosis L.V. Adamyan, Moscow, Russia 10.50 Epidemiology of endometriosis ? Should we change the definition of endometriosis? Ph. Koninckx, Leuven, Belgium 11.10 Endometriosis and pain new chapters of a neverending story A. Ebert, Berlin, Germany 11.30 Deep infiltrating endomezriosis of the rectum - best surgical treatment? Ch. Köhler, Hamburg, Germany 11.50 Deep infiltrating endometriosis: a gynecological perspective Y. Ota, Okayama, Japan 12.10 Complications of deep endometriosis during ART or pregnancy A. Setúbal, Lisbon, Portugal 12.30 Evaluation of effect of modern hormonal therapy on pre-existing endometrioma and prevention of postoperative recurrence I. Ota, Okayama, Japan 12.50 Discussion 13.00-13.30 Lunch break. Exhibition School COMPLICATIONS IN ENDOSCOPIC SURGERY 13.30 Prevention and treatment of vascular complication in laparoscopic surgery А. Ussia, Rome, Italy

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Page 1: DAY 1. June 07, 2016. Tuesday BIG HALL 9.00 Musical ...ceiclinic.pt/wp-content/uploads/2013/04/CONGRESS-PROGRAM.pdf · 11.50 Deep infiltrating endometriosis: a gynecological perspective

DAY 1. June 07, 2016. Tuesday

BIG HALL 9.00 Musical greeting 9.30

Opening of the XXIX International Congress with Endoscopic Course “New Technologies for Diagnosis and Treatment of Gynecologic Diseases”

x Greeting from the Ministry of Health of the Russian Federation Chairman of the Congress Organizing Committee, Director of the Research Center for Obstetrics, Gynecology and Perinatology, Academician of RAS, professor Sukhikh G.T.

x President of the Congress, Deputy Director of the Research Center for Obstetrics, Gynecology and Perinatology, Head Specialist in Obstetrics and Gynecology of the Ministry of Health of Russia, Academician of RAS, professor L.V.Adamyan

10.50 Problematic lecture Assisted reproductive technologies and their impact both positive and negative on obstetrics V. Senikas, Ottawa, Canada

Plenary Session I

ENDOMETRIOSIS – ONE OF THE KEY PROBLEMS IN GYNECOLOGY

Chairmen G.T. Sukhich, O.S. Philippov, L.V. Adamyan, E.L Ailamazyan, G.M. Savelieva, A.N. Strizhakov, V.N. Serov, V.I. Krasnopolsky, L.A. Ashrafyan, M.A. Kurtser, A.D. Makatsaria, I.S. Sidorova, Ph. Koninckx, A. Ebert, Ch. Köhler, Y.Ota, A. Setúbal, I.Ota, А.Ussia, W. Pauker, H.Soleymani

10.30 Challenges in the treatment of endometriosis L.V. Adamyan, Moscow, Russia

10.50

Epidemiology of endometriosis ? Should we change the definition of endometriosis? Ph. Koninckx, Leuven, Belgium

11.10 a. Endometriosis and pain – new chapters of a neverending story b. A. Ebert, Berlin, Germany

11.30 Deep infiltrating endomezriosis of the rectum - best surgical treatment?

Ch. Köhler, Hamburg, Germany

11.50 Deep infiltrating endometriosis: a gynecological perspective Y. Ota, Okayama, Japan

12.10 Complications of deep endometriosis during ART or pregnancy A. Setúbal, Lisbon, Portugal

12.30

Evaluation of effect of modern hormonal therapy on pre-existing endometrioma and prevention of postoperative recurrence I. Ota, Okayama, Japan

12.50 Discussion

13.00-13.30 Lunch break. Exhibition

School COMPLICATIONS IN ENDOSCOPIC SURGERY

13.30

Prevention and treatment of vascular complication in laparoscopic surgery А. Ussia, Rome, Italy

José Sutre
José Sutre
José Sutre
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13.50 Complications of laparoscopic gynecologic surgery

W. Pauker, Bremen, Germany

14.10 Round table: ONCOLOGY AND REPRODUCTIVE HEALTH

14.10 Fertility sparing in patients with gynaecologic cancer H. Soleymani

14.30 Laparoscopic radical hysterectomy Sh. Puntambekar, Pune, India

14.50 Early carcinogenesis and metastatic disease in cancer of reproductive organs L.A. Ashrafyan, Moscow, Russia

15.05 Cyto-reproductive operations with the use of specific surgical techniques A.G. Abdullaev, K.I. Zhordania, Moscow, Russia

15.20 Endoscopic accesses in gynaecological oncology: benefits and limits G.N. Khabas, Moscow, Russia

15.35 Discussion

15.45 – 17.45 Master class: ENDOSCOPIC SURGERY Direct transmission from operating rooms Ph. Koninckx M. Kurtulus Sh. Puntambekar A. Ussia A.S. Arakelyan A. Yu. Danilov A.V. Kozachenko

DAY 2. June 8, 2016. Wednesday

School of experts IMPROVEMENT OF SURGICAL TECHNIQUES FOR TREATMENT OF ENDOMETRIOSIS/ADENOMYOSIS

Chairmen I.S. Sidorova, V.G. Breusenko, A.M. Torchinov, J. Hamou, A. Wattiez, S. Gordts, G. Keckstein, M. Malzoni L. Mencaglia, A. Ebert, A.Setúbal

9.00 Adenomyosis: approach and hysteroscopic treatment J. Hamou, Paris, France

9.20 Nerve Sparing surgery in DIE: Myth or reality? Strasbourg, France

9.40 Ovarian endometrioma: does size matters? S. Gordts, Leuven, Belgium

José Sutre
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10.00 Adenomyosis: diagnosis and conservative surgical treatment

G. Keckstein, Villach, Austria

10.20 Preoperative indications to laparoscopic bowel segmental resection for deep infiltrating endometriosis: the M-rules M. Malzoni, Avellino, Italy

10.40 Hysteroscopy today L.Mencaglia, Сortona, Italy

11.00 Discussion

11.10-12.40 Master class: ENDOSCOPIC SURGERY Direct transmission from operating rooms J. Hamou A. Wattiez S. Gordts G. Keckstein M. Malzoni L. Mencaglia J. Deprest D.V. Valsky A. Ebert A. Setúbal, V. Senikas А.S.Arakelyan А Yu. Danilov А.V.Kozachenko

12.40 Problematic lecture Urogynaecology: why mesh is here to stay? J. Deprest, Lueven, Belgium

13.00-13.30 Lunch break. Exhibition

Round table FETAL MEDICINE

Moderators N.K. Tetruashvili, A.I. Gus

13.30 Fetal surgery for spina bifida - the limits of fetoscopic surgery J. Deprest, Lueven, Belgium

13.50 The fetus as a patient D. Valsky, Jerusalem, Israel

14.10 Discussion

14.20-16.20 Master class: ENDOSCOPIC SURGERY Direct transmission from operating suites J. Hamou A. Wattiez S. Gordts

José Sutre
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G. Keckstein M. Malzoni L. Mencaglia J. Deprest D.V. Valsky A. Ebert A. Setúbal V. Senikas А.S.Arakelyan А Yu. Danilov А.V.Kozachenko

Seminar

WAYS OF OPTIMIZATION OF THE OUTCOMES OF GYNAECOLOGICAL SURGERY

16.20 The possible impact of SPRM in the treatment of different benign gynecological conditions A. Ebert, Berlin, Germany

16.40 The morcellation issue: up to date and impact on European surgeons A. Setúbal, Lisbon, Portugal

17.00 Rare forms of ectopic pregnancy S.I.Kiselev, Moscow, Russia

17.15 Specifities of laparoscopic operations in pregnancy S.A. Martynov, A.Yu. Danilov, V.G. Vardanyan, Moscow, Russia

17.30 New facts about mullerian malformations L.V. Adamyan, Moscow, Russia

17.40 Reproductive surgery of female genital anomalies Z.N.Makiyan, L.V.Adamyan, V.G.Bychenko, A.A.Stepanyan, N.A.Miroshnikova, K.N.Farkhat, Moscow, Russia

17.50 Surgical technologies in ART programs I.F. Kozachenko, A.Yu. Danilov, Z.R. Zurabiani, Moscow, Russia

18.05 Scar condition after reconstructive uterine surgery: problems of niches A.S. Arakelyan, A.A. Martynov, P.M. Khirieva, Moscow, Russia

18.20 Discussion

SMALL HALL

School for young scientists 8.00-9.00

How to write articles for peer-reviewed journals? V. Senikas, Orrawa, Canada

17.30 Working meeting of regional Head Specialists in obstetrics and gynecology

José Sutre
José Sutre
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DAY 3. June 9, 2016. Thursday

Experts school in

cooperation with Centers miVIP (USA)

Modern possibilities of robotic surgery

Chairmen

V.I.Krasnopolskiy,V.B.Nosov, M.Kurtulus, V.Cela

9.00 Advances and latest in robotic surgery M.Kurtulus, Tastin, USA

9.20 Firefly technologies and ICG in robotic surgery V.Cela, Pisa, Italy

9.40 Concept of robotics surgical treatment of gynecological patients V.I.Krasnopolskiy, Moscow, Russia

9.55 Place of robotic surgery in operative gynecology V.B.Nosov, Yu.V.Maksimova, M.M.Sonova, Moscow, Russia

10.10 Technique and tricks for the treatment of endometriosis and myoma with robotic surgery M.Kurtulus, Tastin, USA

10.30 Discussion

10.40 – 12.30 Workshop on endoscopic surgery Direct transmission from operation rooms of the Center and Oxford University Clinics

12.30 – 13.00 Break. Lunch

Research and

education session in

cooperation with

Endometriosis and combined hyperplastic uterus processes: new trends

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European league of

endometriosis

Chairmen

E.N.Andreeva, V.F.Bezhenar, U.E.Dobrokhotova, M.A.Kurtser, S.Renner, H.Tinneberg, M. Friedman

13.00 Modern surgical approaches in endometriosis – what is standard? S.Renner, Erlangen, Germany

13.20 Is endometriosis a risk factor for infertility?

H.Tinneberg, Giessen, Germany

13.40 Association of uterine adenomyosis and pelvic endometriosis in women of reproductive age M. Friedman, Haifa, Israel

14.00 New approaches to ovarian reserve prevention in patients with ovarian endometriosis V.F.Bezhenar, Moscow, Russia

14.15 Surgical treatment of endometriomas. What is important to remember? Yu.E.Dobrokhotova, Moscow, Russia

14.30 What do we know about endometriosis pathogenesis and uterine fibroids - accents for the practitioner M.I.Yarmolinskaya, Moscow, Russia

14.45 How to prevent premature ovarian failure? The surgeon's view V.V.Korennaya, Moscow, Russia

15.00 Preservation of fertility as a mandatory element of the treatment of patients of reproductive age with adenomyosis I.V.Kuznetsova, Moscow, Russia

15.15 Management of patients with combined hyperplastic uterine diseases in 2016 A.Z.Khashukoeva, Moscow, Russia

15.30 Treatment of endometriosis without ovarian reserve reduction in routine practice V.E.Balan, Moscow, Russia

15.45 New medication option for treatment of patients with infertility and small forms of endometriosis A.K.Krasilnikova, A.I.Malyshkina, N.Yu.Sotnikova, A.S.Antsiferova, Ivanovo, Russia

16.00 Combined hyperplastic uterine and uterine bleeding processes: individualized approach E.N.Andreeva, Moscow, Russia

16.15 Complicated course of deep infiltrative endometirosis M.V.Melnikov, V.D.Chuprynin, A.V.Veredchenko, V.V.Chursin, Moscow, Russia

16.30 ART in patients with endometriosis and uterine myoma V.Yu.Smolnikova, E.A.Kalinina, Moscow, Russia

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16.45 Assessment of endometriomas medical treatment effectiveness S.A.Gasparyan, O.S.Popov, I.A.Vasilenko, V.B.Metelin, A.B.Kuznetsov, Stavropol, Russia

17.00 Pathogenic mechanisms of pelvic pain in adenomyosis M.R.Orazov, Moscow, Russia

17.15 Endometriosis-associated chronic pelvic pain: morphological, molecular and immunohistochemical markers A.S.Ovakimyan, Zh.R.Gardanova, E.L.Yarotskaya, L.V.Adamyan, Moscow, Russia

17.30 Research of eutopic and ectopic endometrium of various localization by direct mass spectrometry A.V.Borisova, A.V.Kozachenko, N.L.Starodubtseva, V.V.Chagovets, D.F.Salimova, A.S.Kononikhin, V.E.Frankevich, L.V.Adamyan, Moscow, Russia

17.45 The analysis of activation of signal pathways in eutopic and ectopic endometrium with endometriosis Ya.B.Aznaurova, M.M.Sonova, Moscow, Russia

18.00 Discussion DAY 4. June 10, 2016. Friday

BIG HALL

7.30 LAPAROSCOPIC TRAINING COURSE A.Wattiez, G.Kekstein, Ph.Konninx, M.Kurtulus

9.00 Problematic lecture

Optimization of medical treatment in operative gynecology L.V.Adamyan, Moscow, Russia

Experts’ lectures 9.15

Standards of medical care for uterine scar after cesarean section and placenta ingrowth V.Senikas, Ottawa, Canada

9.35

The role of new organizational approaches and technologies in the prevention of maternal morbidity and mortality A.V.Samoylova, Cheboksary, Russia

Debating Club

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REPRODUCTIVE HEALTH OF ONCOLOGY PATIENTS Moderators

G.N.Khabas, A.Z.Khashukoeva

9.55 Is pregnancy a life threatening risk after breast cancer?

H.Tinneberg, Giessen, Germany

10.15 Endoscopic strategy in patients with endometrial and ovarian cancer H.Soleymani, Oxford, United Kindom

Master-class and demonstration of operations

Current approaches to prolapses correction

Chairmen

A.I.Ischenko. D.A.Pushkar, U.A.Shelygin

10.35 Mini-slings in urogynecology: place and time? D.A.Pushkar, Moscow, Russia

10.50 Laparoscopic vaginal correction of enterocele with mesh implants A.I.Ischenko. A.A.Ischenko, I.D.Khokhlova, L.S.Aleksandrov, Yu.N.Tarasenko, Moscow, Russia

11.05 Gynecological pelvic surgery: coloproctology aspects U.A.Shelygin, U.A.Titov, Moscow, Russia

11.20 New approaches to prosthetic reconstruction of pelvic floor via vaginal access N.V.Ermolova, V.A.Linde, Rostov-on-Don, Russia

11.35 New methods for surgical correction of urogenital prolapse. The first experience in Russia A.N.Nikitin, Moscow, Russia

11.50 New Russian model of obstetric-gynecologic pessary – new possibilities M.G.Shneyderman, Moscow, Russia

12.05 Discussion 12.15-12.45 Break. Lunch

Research and Education Session

Improvement of surgical techniques in uterine fibroids treatment

Chairmen L.V. Adamyan, V.G. Breusenko, I.A.Salov, O.G.Pekarev, B.L.Tsyvyan

12.45 Controversial issues of uterine fibroids treatment Ph.I.Fatkullin, N.A.Ilizarova, Kazan, Russia

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13.00 Laparoscopic myomectomy for large, multiple or transmural myomas: surgical technique, reproductive outcomes K.A.Ovchinnikov, Voronezh, Russia

13.15 Shaver hystero-resectoscopy of submucous myoma I.A.Salov, V.A.Morozova, N.A.Chunikhin, Moscow, Russia

13.30 Features of surgical treatment in women of reproductive age after ineffective UAE and MRI-FUS ablation I.E.Porotikova, T.Yu.Gavrilova, L.V.Adamyan, T.A.Demura, Moscow, Russia

13.45 Complex approach to uterine fibroids treatment in patients of reproductive age Z.V.Revazova, M.M.Sonova, A.V.Kozachenko, L.T.Urumova, E.N.Andreeva, Moscow, Russia

14.00 Vaginal access to cervical myoma treatment B.L.Tsyvyan, S.V.Vardanyan, V.S.Syntsov, E.V.Konstantinova, M.V.Afanasyeva, S.V.Rumyantsev, A.V.Tusikov, Saint-Petersburg, Russia

14.15 Differentiated approach to uterine fibroids treatment: uterus-preserving possibilites O.G.Pekarev, Moscow, Russia

14.30 The molecular mechanisms of pathogenesis of uterine fibroids: gene Med 12 mutation in women with burdened anamnesis N.S.Sagoyan, E.Yu.Tikhonchuk, D.Yu.Trofimov, O.V.Burmenskaya, Moscow, Russia

14.45 Modern roentgen-surgical technologies in treatment of uterine fibroids K.D.Murvatov, Moscow, Russia

15.00 The role of dynamic contrast-enhanced MRI in planning of conservative treatment of uterine fibroids V.G.Bychenko, D.M.Akinfiev,T.Yu.Gavrilova, I.E.Porotikova, Moscow, Russia

15.15 Discussion

Workshop INTERDISCIPLINARY APPROACH TO SURGICAL TREATMENT OF GYNECOLOGICAL PATIENTS

Chairmen

A.Popov, S.V.Shtyrov, O.V.Rogachevskiy

15.20 25 years of operative laparoscopy in urgent gynecology S.V.Shtyrov, Moscow, Russia

15.40 Laparoscopy in obese patients A.Popov, Moscow, Russia

15.55 The advantages of single-port surgery in simultaneous operations in gynecology N.V.Bashmakova, A.A.Lukach, Ekaterinburg, Russia

16.05 Correction of anemia in gynecological patients - an important component of successful surgical treatment O.V.Rogachevskiy, Moscow, Russia

16.20 Cardio-vascular effects of CO2 pneumoperitoneum during laparoscopic surgery: international research project O.A.Mynbaev, A.Tinelli, A.Malvasi, Z.Shi, S.S. Simakov, T. Benhidjeb, M. Stark, Moscow,

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Russia

16.35 Pathogenic features of adhesions formation in patients of reproductive age with uterine myoma L.M.Kondrativich, A.V.Kozachenko, K.S.Mailova, Moscow, Russia

16.50 Discussion 17.00 Congress closing

DAY 4. June 10, 2016. Friday

SMALL HALL

7.30-9.00

Young Scientists’

Contest

Jury L.V.Adamyan, I.I.Baranov, S.V.Pavlovich, T.Yu, Smolnova

Workshop Breast pathology in practice of a gynecologist

Chairmen

V.V.Rodionov, Yu.P.Gaylish

9.00 Integral prognostic indices in the morphological diagnosis of breast cancer V.V.Kometova, Moscow, Russia

9.15 Current aspects of the diagnosis of breast cancer: benefits and implications Yu.P.Gaylish, Moscow, Russia

9.30 Individualization of surgical intervention in the of regional metastases in patients with breast cancer V.V.Rodionov, Moscow, Russia

9.45 Art-psycho-therapy in medical rehabilitation after mastectomy for breast cancer G.R.Gigineyshvili, A.Kh.Gaydarov, O.V.Garshina, Moscow, Russia

10.00 Medical rehabilitation of patients with postmastectomy syndrome A.Kh.Gaydarova, N.V.Kotenko, M.I.Monzhesova, Moscow, Russia

10.15 Discussion

School

Acute problems of pediatric and adolescent gynecology

Chairmen L.V.Adamyan, E.A.Bogdanova, E.V.Sibirskaya, E.V.Uvarova

10.25 Reproductive health of girls and young women in Moscow. Topical issues and solutions E.V.Sibirskaya, L.V.Adamyan, E.A.Bogdanova, I.E.Koltunova, T.A.Smal, Moscow, Russia

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10.40 Features of ovarian reserve in teenage girls and possibility of adjuvant correction of menstruation N.A.Buralkina, I.A.Kiseleva, Moscow, Russia

10.55 Congenital ovarian masses in newborn girls: 10 years of experience in diagnosis and treatment Yu.L.Podurovskaya, E.I.Dorofeeva, A.O.Chelnak, A.P.Panin, E.A.Filatova, N.V.Mashinets, M.I.Pykov, V.N.Demidov, L.V.Adamyan, Moscow, Russia

11.10 Diagnosis and treatment of ovarian masses in girls. Experience of the Department of Gynecology of the Morozov Children's City Hospital E.V.Sibirskaya, I.E.Koltunov, E.E.Petryaykina, E.A.Bogdanova, S.A.Korotkova, Moscow, Russia

11.25 Genital malformations with menstrual outflow obstruction L.V.Adamyan, E.V.Sibirskaya, S.A.Zhuravleva, Moscow, Russia

11.40 The method of surgical treatment of patients with vaginal and cervical aplasia V.D.Chuprynin, N.A.Buralkina, E.V.Uvarova, D.A.Kruglyak, N.Kh.Latypova, Z.K.Batyrova, Moscow, Russia

11.55 Injuries of external genitalia in girls and young women. Treatment and prevention of complications E.V.Sibirskaya, I.E.Koltunova, E.G.Moksyakova, Moscow, Russia

12.10 Discussion 12.20-12.55 Break. Lunch Workshop NEW TECHNOLOGIES IN OBSTETRICS PROBLEMS SOLVING

Chairmen V.E.Radzinskiy, R.G.Shmakov, N.Ya.Kan

12.55

Combined treatment of cervical pregnancy - organ-preserving approach A.V.Kozachenko,V.G.Bychenko, D.A.Akinfiev, Moscow, Russia

13.10 Laparoscopic cerclage in patients with cervical incompetence after operations on the cervix O.V.Aziev, G.M.Savelyeva, Moscow, Russia

13.25 Diagnostics and management of fetal ovarian masses N.V.Mashinets, V.N.Demidov, A.I.Gus, Moscow, Russia

13.40 Complications of multiple pregnancy: possibilities of intrauterine surgical correction K.V.Kostyukov, K.A.Gladkova, N.K.Tetruashvili, A.I.Gus, Moscow, Russia

13.55 Modern technologies of solving the problem of placenta ingrowth V.D.Chuprynin, R.G.Shmakov, N.E.Kan, Moscow, Russia

14.10 Discussion Research and

Education Session

Chairmen A.D.Makatsariya, V.N.Prilepskaya 14.20 Cancer and thrombosis (thrombosis pathogenesis in cancer patients)

A.D.Makatsariya, Moscow, Russia 14.35 The role of intraepithelial changes of fallopian tube in early stages of pathogenesis of

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serous ovarian tumors A.V.Asaturova, A.R.Rakhmatullina, I.F.Kozachenko, Moscow, Russia

14.50 Difficulties in diagnosis of squamous intraepithelial neoplasia G.R.Bayramova, L.S.Ezhova, Moscow, Russia

15.05 Modern method of HPV, uterine dysplasia and cervical cancer treatment M.A.Afanasyev, Moscow, Russia

15.20 Discussion School Hysteroscopy and intrauterine surgery

Chairmen L.M.Kappusheva, Л.М.Каппушева

15.30 Complicated cases in hysterocsopist’s practice S.E.Sarkisov, Omsk, Russia

15.45 Hysteroscopy: the most common mistakes L.M.Kappusheva, Moscow, Russia

16.00 Growth of the importance of hysteroscopy in infertility treatment programs S.A.Martynov, A.S.Arakelyan, I.F.Kozachenko, Z.R.Zarubiani, Moscow, Russia

16.15 Treatment of menorrhagia using thermal destruction of endometrium by a balloon catheter V.Sorkin, Moscow, Russia

16.30 Intrauterine adhesions - treatment and prevention of recurrence T.A.Dzhibladze, Moscow, Russia

16.45 Discussion 16.50 Congress closing