data analysis of strip-line board for...
TRANSCRIPT
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Data Analysis of Strip-Line Board forTOF-PET
Abhinav Prem1,2
1University of Southern CaliforniaLos Angeles, CA
2Fermi National Accelarator LaboratoryBatavia, IL
8th August 2012
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Overview
I Brief Introduction to PET PhysicsI Experimental SetupI Data AnalysisI ConclusionsI ReferencesI Acknowledgements
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First, Some Biology
I Cancer cells have higher than average rate of glucosemetabolism.
I Certain radiotracers, such as 18F-fluoro-deoxy-glucose(18F-FDG) follow metabolic path similar to glucose.
I Unlike glucose, tracers don’t metabolise to CO2 and waterbut remain trapped in tissue.
I Higher density of tracers near cancerous sites.
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Detection
I Positron Emission Tomography (PET) is a radiotracerimaging technique.
I Patient is injected with radionuclide (18F compoundscommon in oncology).
I Trapped radio-tracers decay (t1/2 for 18F = 110 mins).
p→ n + e+ + νe (1)
I e+ annihilates with e− after travelling ∼ 1mm, producing apair of 511 keV γ.
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Coincidences
Figure: Coincidence Detection in PET
I When the photo-detectors placed around patient detect γ, each of themproduces a timed pulse.
I Pulses fed into coincidence circuitry and if two pulses close enough, acoincidence event is recorded.
I Constrains annihilation event along a line.I Spatial resolution of ∼ 10cm attainable with PET technology.
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Limitations of Conventional PET
I In conventional PET, location of individual events is constrained along aline, the Line of Resolution (LOR), and not a point.
I Not all photons pass through undeviated - scattering, random coincidences,
multiple coincidences.I Scattered coincidences - γ undergoes Compton scattering before
detection. Event assigned to wrong LOR. Adds statistical noise tosignal.
I Random coincidences - γ not from same event reach detectors withincoincidence window. Also add statistical noise.
I Multiple coincidences - More than two γ detected within coincidencewindow. Causes event mis-positioning.
Figure: Types of CoincidencesA. Prem PET-TOF Analysis 6/23
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Health Effects
I ∼ 15 mSv is allowed level of radiation exposure forradiation workers at Fermilabs.
I For adults, exposure from single PET scan ∼ 8 mSv.I From PET+CT ∼ 30 mSv.I Radiation effects cumulative in nature.I Probability of developing oncological complications from a
single PET scan on order of 0.1%I Use of PET as a diagnostic tool limited.
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Layout
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Strip-Line Board
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Conclusions
I Strip-Line boards provide cost effective method ofidentifying which crystals detect γ
I Timing Resolution of 30ps reproducible using describedfitting procedure.
I Corresponds to spatial resolution of ∼ 2.1 mm (FWHM).I For SiPM pitch of 5mm, this resolution allows us to identify
the SiPM on the Strip-Line at a level of σ ∼ +/- 2mm.
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References
I Moses, William W. ‘Recent Advances and Future Advancesin Time-of-Flight PET’. Nucl Instrum Methods Phys ResA. 2007 October 1. 580(2): 919924.
I http://depts.washington.edu/nucmed/IRL/pet intro/index.html
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Acknowledgements
I Pavel MuratI Anatoly RonzhinI Eric RambergI Roger DixonI Carol Angarola
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