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DAFTAR ISI
HALAMAN JUDUL ................................................................................................ i
HALAMAN PENGESAHAN ................................................................................ ii
SURAT PERNYATAAN....................................................................................... iii
PRAKATA ............................................................................................................. iv
DAFTAR ISI .......................................................................................................... vi
DAFTAR SINGKATAN ....................................................................................... ix
DAFTAR TABEL ................................................................................................... x
DAFTAR GAMBAR ............................................................................................. xi
DAFTAR LAMPIRAN ......................................................................................... xii
INTISARI ............................................................................................................. xiii
BAB I PENDAHULUAN .................................................................................. 1
1.1 Latar Belakang .................................................................................. 1
1.2 Rumusan Masalah ............................................................................ 4
1.3 Tujuan Penelitian .............................................................................. 4
1.3.1 Tujuan Umum ......................................................................... 4
1.3.2 Tujuan Khusus ........................................................................ 4
1.4 Manfaat Penelitian ............................................................................ 5
1.4.1 Manfaat Teoritis ...................................................................... 5
1.4.2 Manfaat Praktis ....................................................................... 5
BAB II TINJAUAN PUSTAKA ......................................................................... 6
2.1 Malondialdehyde (MDA) ................................................................. 6
2.1.1 Definisi .................................................................................... 6
2.1.2 Cara Pengukuran ..................................................................... 7
2.1.3 Faktor-faktor yang Mempengaruhi MDA ............................... 7
2.1.4 Stress Oksidatif ....................................................................... 8
2.1.5 Proses Pembentukan ROS ....................................................... 9
2.2 Asupan Kalori ................................................................................. 10
2.2.1 Definisi .................................................................................. 10
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2.2.2 Faktor-faktor yang Mempengaruhi Asupan Kalori ............... 11
2.2.3 Asupan Kalori Berlebih ........................................................ 12
2.2.4 Pembatasan Asupan Kalori ................................................... 13
2.2.5 Variasi Asupan Kalori ........................................................... 13
2.3 Hewan Coba ................................................................................... 14
2.4 Pengaruh Pemberian Variasi Asupan Kalori Terhadap Kadar
MDA ............................................................................................... 14
2.5 Kerangka Teori ............................................................................... 16
2.6 Kerangka Konsep ........................................................................... 17
2.7 Hipotesis ......................................................................................... 17
BAB III METODE PENELITIAN ..................................................................... 18
3.1 Jenis Penelitian dan Rancangan Penelitian ..................................... 18
3.2 Variabel dan Definisi Operasional ................................................. 18
3.2.1 Variabel ................................................................................. 18
3.2.2 Definisi Operasional ............................................................. 18
3.3 Populasi dan Sampel ....................................................................... 19
3.3.1 Populasi Penelitian ................................................................ 19
3.3.2 Sampel Penelitian .................................................................. 19
3.4 Alat dan Bahan Penelitian .............................................................. 20
3.4.1 Alat ........................................................................................ 20
3.4.2 Bahan .................................................................................... 20
3.5 Cara Penelitian ................................................................................ 21
3.5.1 Adaptasi Hewan Coba ........................................................... 21
3.5.2 Randomisasi dan Pembagian Kelompok............................... 22
3.5.3 Pemberian Pakan ................................................................... 22
3.5.4 Pengambilan Sample Darah .................................................. 23
3.6 Tempat dan Waktu ......................................................................... 23
3.7 Analisis Hasil .................................................................................. 23
3.8 Alur Penelitian ................................................................................ 24
BAB IV HASIL PENELITIAN DAN PEMBAHASAN .................................... 25
4.1. Hasil Penelitian ............................................................................... 25
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4.2. Pembahasan .................................................................................... 28
BAB V KESIMPULAN DAN SARAN ............................................................ 32
5.1. Kesimpulan ..................................................................................... 32
5.2. Saran ............................................................................................... 33
DAFTAR PUSTAKA ........................................................................................... 34
LAMPIRAN ........................................................................................................... 42
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DAFTAR SINGKATAN
ADF : Alternate Day Fasting
ATP : Adenosin Tri Phosphate
BMR : Basal Metabolic Rate
CALARIE : The Comprehensive Assessment of Long-Term Effect of
Reduction Intake Energy Trial
DNA : Deoxyribo Nucleic Acid
DR : Dietary Restriction
ETC : Electron Transport Chain
FADH2 : Flavin Adenine Dinucleotide Hydride2
FR : Free Radical
HLPC : High Performance Liquid Chromatograpy
MDA : Malondialdehyde
NADH : Nicotinamide Adenine Dinucleotide Hydride
PUFA : polyunsaturated fatty acid
RM : Reactive Metabolites
ROS : Reactive Oxygen Species
TBARS : Thiobarbituric acid reactive substances
TGT : Toleransi Gula Terganggu
DMT2 : Diabetes Melitus Tipe 2
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DAFTAR TABEL
Tabel 3.1. Kompisisi AIN-93M ........................................................................... 20
Tabel 4.1. Hasil pengukuran kadar MDA serum pada kelima kelompok uji ...... 26
Tabel 4.2. Hasil analisis normalitas data dan homogenitas varian kadar MDA
serum antar kelompok ........................................................................ 27
Tabel 4. 3. Hasil uji Kruskall Wallis kadar MDA serum antar kelompok ........... 27
Tabel 4.4. Hasil uji Mann Whitney perbedaan kadar MDA antar dua kelompok 28
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DAFTAR GAMBAR
Gambar 4.1. Rata-rata kadar MDA Serum (nmol/ml) antar kelompok uji ........... 26
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DAFTAR LAMPIRAN
Lampiran 1. Data Penelitian .................................................................................. 37
Lampiran 2. Hasil analisis statistik dengan SPSS ................................................. 38
Lampiran 3. Ethical Clearance ............................................................................. 43
Lampiran 4. Surat Keterangan Bebas Peminjaman............................................... 44
Lampiran 5. Laporan Hasil Uji ............................................................................. 44
Lampiran 6. Dokumentasi Penelitian .................................................................... 47