d. james cooper russell gruen national health & medical research council (nhmrc) funding dates:...
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D. James CooperRussell Gruen
National Health & Medical Research Council (NHMRC)
Funding dates: 2014-2016
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The Alfred, Melbourne Australia
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supported
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ANZIC-Research Centre, Monash University
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High impact TBI research for 15 years
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Current multicenter RCTs
N=500Severe TBI, Prophylactic hypothermiaEarly/prolonged/slow
N=600Mod /severe TBIErythropoietin
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Overview
Primary research question or hypothesis Comparative Effectiveness Research approach will identify
most effective clinical interventions for TBI pts world-wideNumber of subjects
100 ICU at Alfred Hospital; (1800 ICU in CENTER)Study design
Prospective longitudinal observational cohort study Australian ICU stratum sites within global CER
Aus: Trauma system, multi-discipline ICU, intensivist led, high nursing ratios, outcomes Registries, collaborative research ethic
Living reviews / translation hub Complete Australian TBI RCTs with Europe sites
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Participation in InTBIR
What are your expectations for joining InTBIR? Help maximize strength of global TBI collaboration Maximize TBI patient diversity within InTBIR Working within InTBIR will enable Global results to
best inform our management, speed of translation, and guide research
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Participation in InTBIR
How might your participation contribute to achieving the mission of InTBIR ? Assist patient recruitment in ICU stratum of CENTER Assist generalizability European findings to another
first world center Broaden practice variation for the world-wide CER Link Australia into the global collaboration Compare Australian structures / therapies / outcomes
with other world centers
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Participation in InTBIR
Do you already have an ongoing collaboration with InTBIR projects? What successes and issues so far?
Collaboration with CENTER-TBI Success: Collaborative NHMRC-EC Funding Issues: Funding cut by 2/3 ($375K/3 yrs). CRE grant
for TBI research and OzENTER – not successful. Monash Co-ordination Centre and Translation Centre Planning for modified start up at Alfred late 2014
MRI/DTI technical issues tested over 2 years
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Participation in InTBIR
Is the funding agency currently supporting your project open to international collaboration under the umbrella of InTBIR?
In principle - Yes.