cytokines slackers facts by mike ori. disclaimer the information represents my understanding only so...
Post on 19-Dec-2015
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TRANSCRIPT
Cytokines
Slackers Facts by Mike Ori
Disclaimer
The information represents my understanding only so errors and omissions are probably rampant. It has not been vetted or reviewed by faculty. The source is our class notes.
The document can mostly be used forward and backward. I tried to mark questionable stuff with (?).
If you want it to look pretty, steal some crayons and go to town.
Finally…
If you’re a gunner, buck up and do your own work.
IL-1 Secretor
Macrophage
IL-1 effects
PyrogenicAcute inflammatory signal
IL-2 Secretor
Activated T helpers
IL-2 effects
Growth of T helpers and cytotoxic T’s
IL-3 secretor
Activated T cells
IL-3 effects
Stem cell growth in marrow similar to GM-GSF
IL-4 Secretor
TH2 cellsMast cells
IL-4 effects
Growth of B cellsIg class switching
IL-5 Secretor
TH2 cellsMast cells
IL-5 Function
B cell differentiationIgA class switch (notes have IgG1)
Eosinophil production and activation
IL-6 Secretor
T helpers and macrophages
Il-6 function
Stimulates acute phase reactants and Ig
IL-7 Secretor
Thymic and bone marrow stromal cells
IL-7 function
Survival signal for immature T and B cells
IL-8 secretor
Macrophages
IL-8 Function
Major neutrophil chemotactic factor
IL-10 Secretor
T regNOTE: Table in notes is different. See
Mechanisms of immunity 12.
IL-10 function
Inhibits activated T cells
IL-12 secretor
B cells and macrophages
IL-12 function
Activates TH1 cells and NK cells
IL-13 Secretor
TH2 cells
Il-13 Function
Stimulates allergic response
IFN-gamma Secretor
TH1 cells
IFN-gamma function
Activates macrophages
IFN-I Secretor
Dendritic cells
IFN-I effects
General antiviral effectsAntiproliferative action for somatic cells
Signal 3 for T Cells
CD3 cell
T cells
CD 4 cells
T helper (TH1, TH2, TH17)
CD28 cell
T Helper
CD40L cell
T Helper
CD8 cell
Cytotoxic T cells
CD19 cell
B cells
CD20 cells
B cells
CD 40 cells
APC’sB cells, dendritic cells, macrophages
MHC-II cells
APC cells
TNF Alpha Secretor
Macrophages
TNF alpha function
Proinflammatory cytokineApoptosis signal (weak?)
GM-CSF secretor
MonocytesT cells
GM-CSF function
Stimulates the marrow to produce monocytes and granulocytes
FAS receptor cells
Most (all?) human cells
Fas ligand cells
CD8 Cytotoxic T cells
FAS function
Induces apoptosis in host cells when signaled by CD8 cells.
Signal 1 components
TCR interacts with MHC-II along with CD4
Signal 2 components
B7 molecule on APC interact with CD-28 on T cells.
Signal 3
IL-12, IFN-I