cynthia czajkowski, ph.d. education · czajkowski cv 3 2011 – 2016 cassie theusch, postdoctoral...

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CYNTHIA CZAJKOWSKI, Ph.D. University of Wisconsin Madison Department of Neuroscience 1111 Highland Drive Madison, WI 53711 (608) 265-5863 (Office); (608) 265-7821 (FAX) [email protected] EDUCATION 1987 State University of New York, Health Science Center at Brooklyn Ph.D., Anatomy and Cell Biology; Thesis advisor: Dr. David H. Farb Thesis title: “Transmembrane topology, subcellular distribution and turnover of the GABA A /benzodiazepine receptor in chick brain cell culture.” 1979 New York University B.A., Biology (Dean’s List) PROFESSIONAL POSITIONS 2011 pres Professor, University of Wisconsin-Madison, Dept. of Neuroscience 2005 2011 Professor, University of Wisconsin-Madison, Dept. of Physiology 2005 2006 Interim Chair, Neuroscience Training Program, University of Wisconsin 2000 - 2005 Associate Professor, University of Wisconsin-Madison, Dept. of Physiology 1994 - 2000 Assistant Professor, University of Wisconsin-Madison, Dept. of Physiology 1992 - 1994 Associate Research Scientist, Columbia University, Center for Molecular Recognition, Dept. of Biochemistry and Molecular Biophysics 1987 - 1992 Postdoctoral Research Scientist in the laboratory of Dr. Arthur Karlin, Columbia University, Dept. of Biochemistry and Molecular Biophysics HONORS 2012 UW- Vilas Distinguished Achievement Professor 2008 Dr. Brenda Pfaehler Award of Excellence, TRIO program for mentoring undergraduate students from underrepresented backgrounds 2004 College de France: Distinguished Lecturer 2001 The National Alliance for Research on Schizophrenia and Depression, Independent Investigator Award 1996 Burroughs Wellcome Fund, New Investigator Award 1996 Basil O’Connor Starter Scholar, March of Dimes Foundation 1989 - 1991 NSRA Training Fellowship, Columbia University 1985 - 1987 Predoctoral graduate research fellowship, SUNY, Health Science Ctr. at Brooklyn 1986 Sigma Xi, Scientific Research Society 1975 - 1979 New York University, Four-Year Scholastic Scholarship 1975 New York State Regent’s Scholarship (declined)

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Page 1: CYNTHIA CZAJKOWSKI, Ph.D. EDUCATION · Czajkowski CV 3 2011 – 2016 Cassie Theusch, Postdoctoral Scientist (Honors: Biophysical Society Travel Award 2015, Papers: primary author

CYNTHIA CZAJKOWSKI, Ph.D.

University of Wisconsin – Madison

Department of Neuroscience

1111 Highland Drive

Madison, WI 53711

(608) 265-5863 (Office); (608) 265-7821 (FAX)

[email protected]

EDUCATION

1987 State University of New York, Health Science Center at Brooklyn

Ph.D., Anatomy and Cell Biology; Thesis advisor: Dr. David H. Farb

Thesis title: “Transmembrane topology, subcellular distribution and turnover of

the GABAA/benzodiazepine receptor in chick brain cell culture.”

1979 New York University

B.A., Biology (Dean’s List)

PROFESSIONAL POSITIONS

2011 – pres Professor, University of Wisconsin-Madison, Dept. of Neuroscience

2005 – 2011 Professor, University of Wisconsin-Madison, Dept. of Physiology

2005 – 2006 Interim Chair, Neuroscience Training Program, University of Wisconsin

2000 - 2005 Associate Professor, University of Wisconsin-Madison, Dept. of

Physiology

1994 - 2000 Assistant Professor, University of Wisconsin-Madison, Dept. of

Physiology

1992 - 1994 Associate Research Scientist, Columbia University, Center for Molecular

Recognition, Dept. of Biochemistry and Molecular Biophysics

1987 - 1992 Postdoctoral Research Scientist in the laboratory of Dr. Arthur Karlin,

Columbia University, Dept. of Biochemistry and Molecular Biophysics

HONORS

2012 UW- Vilas Distinguished Achievement Professor

2008 Dr. Brenda Pfaehler Award of Excellence, TRIO program for mentoring

undergraduate students from underrepresented backgrounds

2004 College de France: Distinguished Lecturer

2001 The National Alliance for Research on Schizophrenia and Depression,

Independent Investigator Award

1996 Burroughs Wellcome Fund, New Investigator Award

1996 Basil O’Connor Starter Scholar, March of Dimes Foundation

1989 - 1991 NSRA Training Fellowship, Columbia University

1985 - 1987 Predoctoral graduate research fellowship, SUNY, Health Science Ctr. at

Brooklyn

1986 Sigma Xi, Scientific Research Society

1975 - 1979 New York University, Four-Year Scholastic Scholarship

1975 New York State Regent’s Scholarship (declined)

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Czajkowski CV

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PROFESSIONAL SOCIETIES

American Society for Pharmacology and Experimental Therapeutics (ASPET)

Biophysical Society

Society of Neuroscience

TEACHING ACTIVITIES - CLASSROOM

2016 Instructor, Chemistry 872, Topics in Biophysics, (predoctoral instruction)

U. of Wisconsin-Madison

2010 - 2014 Course Director, Cell and Molecular Neuroscience 610, (predoctoral

instruction) Dept. of Physiology, U. of Wisconsin-Madison

2001 - pres Instructor, Neuroscience 675, Undergraduate neurobiology seminar

1997 - 2014 Instructor, Cell and Molecular Neuroscience 610, (predoctoral instruction)

Dept. of Physiology, U. of Wisconsin-Madison

1995 - 2011 Instructor, Biochemical Pharmacology711: Neurotransmitter

Receptor/Ion Channels (predoctoral instruction) Dept. of Pharmacology,

U. of Wisconsin-Madison

1997 - pres Instructor, Professional Development Course (predoctoral instruction)

Neuroscience Training Program, U. of Wisconsin-Madison

2011 Instructor, Chemistry 872, Topics in Biophysics, U. of Wisconsin-

Madison

Spring 2010 Seminar Moderator, Neuroscience 990,Topics in Neuroscience,

(predoctoral instruction) Neuroscience Training Program, U. of

Wisconsin-Madison

2007 Instructor, Neurobiology 500, undergraduate seminar series

2005 Instructor, Neurobiology 500, undergraduate seminar series

2004 Instructor, Neuroscience 990, Neuroscience –Channelopathy subgroup

2001 - 2008 Instructor (small groups), Medical Physiology 711 (medical student

instruction) Dept. of Physiology, U. of Wisconsin-Madison

1995 - 1997 Instructor, Medical Neurosciences, (medical student instruction) Dept. of

Neurophysiology, U. of Wisconsin-Madison

Fall 1996 Seminar Moderator, Topics in Neuroscience, (predoctoral instruction)

Neuroscience Training Program, U. of Wisconsin-Madison

1991 - 1993 Lecturer, Neurobiology of Disease course for PGY2 psychiatry residents,

Columbia University, NY, NY

1987 - 1989 Instructor, Neurobiology summer course, Marine Biological Laboratories,

Woods Hole, MA

1980 - 1983 Graduate Teaching Assistant, Neuroscience and Gross Anatomy courses

SUNY, Health Science Center at Brooklyn, College of Medicine

1978 - 1979 Laboratory Instructor, Biology, Chemistry and Physics, Elizabeth Irwin

High School, NY, NY

TEACHING ACTIVITIES - MENTORING

Postdoctoral Trainees:

2014 - pres Namrta Purwar, Postdoctoral Research Fellow

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2011 – 2016 Cassie Theusch, Postdoctoral Scientist (Honors: Biophysical Society

Travel Award 2015, Papers: primary author 2 papers in preparation,

Currently - Instructor, Life Sciences, University of Arkansas

2008 – 2013 Cosma Dellisanti, Postdoctoral Research Fellow (Papers: primary author

two papers. Currently: Assistant Editor: Nature Molecular and Structural

Biology)

2011 – 2012 Kurt Laha, Postdoctoral Research Fellow (Papers: primary author one

paper. Currently: Scientific Proposal Leader, Catalent Pharma Solutions,

Madison, Wisconsin.

2006 – 2009 Susan Hanson, Postdoctoral Trainee, Dept. of Physiology, U. of

Wisconsin (Honors: Awarded individual postdoctoral NRSA from NIH,

awarded Society for Neuroscience Travel Award, 2007; Papers: primary

author three papers, co-author one paper, 3 abstracts) Currently: Asst.

Professor Lecturer, Carroll University, Waukesha, WI

2005- 2006 Spencer Ericksen, Postdoctoral Trainee, Dept. of Physiology, U. of

Wisconsin (Papers: co-author two papers) Currently: Assistant Scientist -

Small Molecule Screening Facility, Carbonne Cancer Center, University

of Wisconsin - Madison.

2005- 2006 Leonardo Hernandez Hernandez, Postdoctoral Trainee, Dept. of

Physiology, U. of Wisconsin. Currently: Profesor Tiempo Completo

Titular "A" at Universidad de Guadalajara, CUCS, Mexico

2001 - 2003 Glen Newell, Postdoctoral Trainee, Dept. of Physiology, U. of Wisconsin

(Honors: Awarded postdoctoral NSERC fellowship from Canada; Papers:

primary author of three papers, 1 review article, 2 abstracts) Currently:

Associate Director Clinical Pharmacology, Biovail Contract Research

Ontario, Canada

1997 - 2001 David Wagner, Postdoctoral Trainee, Dept. of Physiology, U. of

Wisconsin (Honors: Awarded individual postdoctoral NRSA from NIH;

Papers: primary author one paper, coauthor three papers, 5 abstracts)

Previous: Assistant Professor at Marquette University, Currently:

unknown

1994 - 1997 Andrew Boileau, Postdoctoral Trainee, Dept. of Neurophysiology, U. of

Wisconsin (Papers: primary author 3 papers, coauthor of 2 papers, 7

abstracts) Currently: Assoc. Prof. and Director of Neuroscience, Saba

University of Medicine, Netherlands Antilles,

1994 - 1996 Nicholas Cozzi, Postdoctoral Trainee, Dept. of Neurophysiology, U. of

Wisconsin-Madison. Currently: Associate Scientist and Lecturer, Cell &

Regenerative Biology Department, School of Medicine & Public Health,

University of Wisconsin – Madison (Papers: 1 abstract)

Predoctoral Student Trainees:

2015 - pres Jennifer Borchardt, Cell and Molecular Biology

2013 - pres Tzu-Wei (Vicki) Tsao, Physiology Graduate Training Program (Papers:

primary author one paper in preparation, 2 abstracts)

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2013 - pres Varun Tiwari, Biophysics Training Program (Honors: Biophysical

Society Travel Award, 2016; Papers: primary author 1 paper in

preparation, 2 abstracts)

2009 - 2014 Borna Ghosh, Biophysics Training Program (Awarded Ph.D. Honors:

Biophysical Society Travel Award, 2013; Papers: primary author 1 paper,

co-author 2 papers, 4 abstracts, primary author 1 paper in preparation;

Currently: post-doc in lab of Chris Lingle at Washington University, St.

Louis)

2008 - 2012 Elaine Morlock, Molecular and Cellular Pharmacology Program (Awarded

Ph.D. Honors: awarded individual predoctoral NIH-NRSA, Vilas travel

award, Papers: primary author 1 paper, co-author 1 paper, 2 abstracts,

Currently: Patent agent at Mintz Levin Law Firm, San Francisco, CA,

admitted to law school)

2009 - 2011 Valerie Grant, Neuroscience Training Program (Awarded M.S. Papers:

coauthor one paper. Honors: awarded individual NSF predoctoral

fellowship, Currently in Med. School)

2005 - 2011 Kelly Christopherson, Molecular and Cellular Pharmacology Program.

(Awarded Ph.D. Honors: awarded individual predoctoral NIH-NRSA,

awarded Vilas 2008 Travel Grant, Papers: Primary author 1 paper, co-

author 1 paper, 2 abstracts) Currently: stay at home Mom when husband

took position at Astrazeneca in England

2004 - 2010 Cassandra Theusch, Cell and Molecular Biology Training Program

(Awarded Ph.D., Papers: co-author 1 paper, primary author of 4 abstracts)

Currently, Instructor, Life Sciences, University of Arkansas.

2004 - 2008 Srinivasan Venkatachalan, Physiology Training Program (Awarded Ph.D.

Papers: primary author 2 papers, 5 abstracts; Honors: Awarded Society for

Neuroscience Travel Award, 2007; Biophysical Society Travel Award,

2008, FASEB Travel Award, 2008) Currently, Senior Research Scientist,

Cromocell Corporation, New Jersey.

2003 - 2007 Jose Mercado, Neuroscience Training Program (Awarded Ph.D. Papers:

primary author of 2 papers, 2 abstracts; Honors: Awarded Predoctoral

Fellowship from American Psychological Society, Biophysical Society

Travel Award) Currently, Scientist at Kineta Inc. Seattle, Washington.

2002 - 2006 Feyza Sancar, Neuroscience Training Program (Awarded Ph.D. Papers:

primary author of 3 papers, 2 abstracts; Honors: Awarded Predoctoral

Fellowship from Epilepsy Foundation of America; Awarded Eli Lilly

Outstanding Graduate Student in Neuroscience Travel Fellowship - 2005)

Currently, Director of Medical News and Perspectives, Journal of the

American Medical Association.

2000 - 2004 Lisa Sharkey, Neuroscience Training Program (Awarded Ph.D. Papers:

primary author of 1 paper, coauthor of 1 paper, 3 abstracts; Honors:

Awarded Eli Lilly Outstanding Graduate Student in Neuroscience Travel

Fellowship – 2002). Currently - Research Investigator in Dr. Henry

Paulson laboratory, Univ. of Michigan

1998 - 2003 Jessica Holden-Kloda, Molecular and Cellular Pharmacology Training

Program (Awarded Ph.D. Honors: Awarded predoctoral fellowships from

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Epilepsy Foundation of America and from Pharmaceutical Manufacturers

of America Papers: primary author of 2 papers, 5 abstracts.) Currently:

Regulatory Compliance Specialist, Technical Resources International Inc.

Bethesda, MD

1997- 2001 Jeremy Teissere, Neuroscience Training Program (Awarded Ph.D.

Honors: Awarded individual predoctoral NRSA from NIH Papers:

primary author two papers, coauthor of one paper, 4 abstracts) Currently:

Associate Professor at Muhlenberg College, Stanley Road Endowed Chair,

Director Neuroscience Program, Allentown, PA.

1997-1998 Jolien Connor, Neuroscience Training Program (left program, Papers:

primary author of 1 paper and 1 abstract; Currently: Scientist – facility

manager of confocal microscope facility, University of Wisconsin –

Madison.

Predoctoral Sponsored Laboratory Rotations:

2014 Caitlin Short Neuroscience Training Program

John Cowgill Biophysics Training Program

Harrison Pantera Molecular and Cellular Pharmacology Program

Jenn Borchardt Cell and Molecular Biology

2013 Joseph Wszalek Neuroscience Training Program (JD/PhD)

2012 Khoa Tran Molecular and Cellular Pharmacology Program

Emily Grant Molecular and Cellular Pharmacology Program

Joe Pasquarelle Molecular and Cellular Pharmacology Program

Erin Hannigan Neuroscience Training Program

Tzu-Wei Tsao Physiology Training Program

Sonalee Bathakur Physiology Training Program

Varun Tiwari Biophysical Training Program

2011 Ewa Bomba Neuroscience Training Program

2010 Kevin Oesltrom Molecular and Cellular Pharmacology Program

Mike Devinney Neuroscience Training Program

2008 Nima Ghitani Neuroscience Training Program

Borna Ghosh Biophysical Training Program

Valerie Grant Neuroscience Training Program

2007 Lindsay Pascal Neuroscience Training Program

Elaine Morlock Molecular and Cellular Pharmacology Program

Deborah Capes Molecular and Cellular Pharmacology Program

Andrew Petersen Molecular and Cellular Pharmacology Program

Joe Esquibel Molecular and Cellular Pharmacology Program

2005 Neil Daily Molecular and Cellular Pharmacology Program

Kelly Christopherson Molecular and Cellular Pharmacology Program

2003 Dominique Fontanilla Molecular and Cellular Pharmacology Program

Cynthia Koziol Molecular and Cellular Pharmacology Program

Cassie Theusch Cell and Molecular Biology Program

2002 Jose Mercado Neuroscience Training Program

2001 Feyza Sancar Neuroscience Training Program

Reema Jasuja Molecular and Cellular Pharmacology Program

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Ashley Doane Molecular and Cellular Pharmacology Program

2000 Lisa Sharkey Neuroscience Training Program

Xue Han Department of Physiology Training Program

Qi-Qi Cui Department of Physiology Training Program

Jill Sakai Neuroscience Training Program

1999 Anthony Guillen Department of Physiology Training Program

1998 Jessica Holden Molecular and Cellular Pharmacology Program

Allison Friedlein Molecular and Cellular Pharmacology Program

Gail Seabold Molecular and Cellular Pharmacology Program

Eric Peden Molecular and Cellular Pharmacology Program

Michel Parsons Neuroscience Training Program

1997 Jolien Connor Neuroscience Training Program

Regan Thieller MD/PhD Training Program

Scott Doughman Molecular and Cellular Pharmacology Program

Jeremy Teissere Neuroscience Training Program

1996 Monika Davare Molecular and Cellular Pharmacology Program

John C. Zella Department of Neurophysiology Training Program

1995 Soren Leonard Molecular and Cellular Pharmacology Program

Predoctoral Thesis Committees:

1994 - 1996 HaiGuang Zhang , Physiology Training Program (M. Jackson -advisor)

1995 - 1996 Inyeong Choi, Developmental Biology Training Program ( B. Chiu -

advisor)

1995 - 1998 Jeannie David, Neuroscience Training Program (L. Trussel - advisor)

1995 - 1998 Matthew Trudeau, Physiology Training Program (G. Robertson - advisor)

1995 - 1999 Xiao-Shen Li , Zoology Training Program (R. Pearce - advisor)

1995 - 2000 Tongbin Li, Neuroscience Training Program (R. Pearce - advisor)

1995 - 2000 Brian Spencer, Medical Microbiology & Immunology Training Program

(C. Brandt - advisor)

1996 - 2001 Jinling Wang, Physiology Training Program (G. Robertson - advisor)

1997 - 2000 Monika Devare, Molecular and Cellular Pharmacology Program (J. Hell –

advisor)

1997 - 2001 David Thiriot, Molecular and Cellular Pharmacology Program (A. Ruoho

- advisor)

1998 - 2000 Sean O’Shea, (University of Chicago, Dr. Neil Harrison - major professor)

1999 - 2001 Bimal Vyas, Neuroscience Training Program (E. Chapman - advisor)

1999 - 2002 Chris Ahern, Physiology (R. Coronado – advisor)

1999 - 2003 Gail Seabold, Molecular and Cellular Pharmacology Program (J. Hell -

advisor)

2000 - 2003 Jihong Bai, Biophysics Training Program (E. Chapman - advisor)

2001 - 2003 David Sheridan, Physiology (R. Coronado – advisor)

2002 - 2004 Christine Angevine, Biomolecular Chemistry (R. Fillingame – advisor)

2000 - 2004 Min Dong, Neuroscience Training Program (E. Chapman - advisor)

2000 - 2004 Eric Kinzler, Cell and Molecular Biology (Teresa Compton – advisor)

2003 - 2005 Xue Han, Physiology Training Program (M. Jackson – advisor)

2000 - 2005 Jason Hardie, Neuroscience Training Program (R. Pearce – advisor)

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2001 - 2006 Yukiko Muroi, Molecular and Cellular Pharmacology Program (M.

Jackson – advisor)

2002 - 2006 Weijun Chang, Physiology Training Program (R. Coronado – advisor)

2002 - 2006 Adam Feire, Cell and Molecular Biology (Teresa Compton – advisor)

2003 – 2005 Adam Rucker, Neuroscience Training Program (G. Robertson – advisor)

2002 - 2006 Rebekah Jakel, Neuroscience Training Program (J. Johnson – advisor)

2003 - 2006 Reema Jasuja, Molecular and Cellular Pharmacology Program (D.

Greenspan – advisor)

2003 - 2007 Pallavi Phartiyal, Cell and Molecular Biology (G. Robertson – advisor)

2006 – 2008 Shu Mao, Physiology Training Program (G. Marriot – advisor)

2003 – 2008 Subramaniam Ramachandran, Molecular and Cellular Pharmacology

Program (A. Ruoho – advisor)

2005 – 2009 Sarah Wynia, Cell and Molecular Biology (G. Robertson – advisor)

2005 - 2009 Enfu Hui, Biophysics Training Program (E. Chapman - advisor)

2004 – 2009 Elon Roti Roti, Cell and Molecular Biology (G. Robertson – advisor)

2004 – 2010 Dominique Fontanilla, Molecular and Cellular Pharmacology Program (A.

Ruoho – advisor)

2005 – 2010 Chuenchanok Frasier, Neuroscience Training Program (T. Martin –

advisor)

2006 – 2010 Cabell Jonas, Cell and Molecular Biology (L. Puglielli– advisor)

2006 – 2010 Michelle Perry, Molecular and Cellular Pharmacology Program (A. Kelley

– advisor)

2007 – 2010 Molly Johannessen, Physiology Training Program (M. Jackson – advisor)

2009 – 2010 Sarah Baisley, Neuroscience Training Program (C. Auger – advisor)

2005 - 2011 Felix Yeh, Molecular and Cellular Pharmacology Program (E. Chapman -

advisor)

2005 – 2011 Brian Torres, Molecular and Cellular Pharmacology Program (A. Ruoho –

advisor)

2007 – 2012 Jesus Mena, Neuroscience Training Program (B. Baldo – advisor)

2007 – 2012 Corinne Vokoun, Molecular and Cellular Pharmacology Program (M.

Basso – advisor)

2008 – 2012 Deborah Capes, Molecular and Cellular Pharmacology Program (B.

Chanda – advisor)

2008 – 2012 Sung (Sam) E Kwon, Physiology Training Program (E. Chapman -

advisor)

2008 – 2013 Shilpashree Balakrishnan, Neuroscience Training Program (R. Pearce –

advisor)

2006 – 2013 Neil Daly, Molecular and Cellular Pharmacology Program (T. Martin –

advisor)

2008 – 2015 Joseph Esquibel, Molecular and Cellular Pharmacology Program (T.

Martin – advisor)

2010 – 2015 Lindsey Roper, Molecular and Cellular Pharmacology Program (E.

Chapman - advisor)

2011 – 2015 Che-wei Chang, Physiology Training Program (M. Jackson, advisor)

2013 – 2015 Joe Pasquarella, Molecular and Cellular Pharmacology Program (R.

Kalejta – advisor)

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2011 – 2015 Kevin Oelstrom, Molecular and Cellular Pharmacology Program (B.

Chanda – advisor)

2011 – 2015 Yun Ding, Neuroscience Training Program (L. Puglielli– advisor)

2011 – 2016 Brandon Wright, Physiology Training Program (M. Jackson, advisor)

2012 – pres Yaxian Zhao, Physiology Training Program (G. Robertson, advisor)

2013 - pres Sofiya Hupalo, Neuroscience Training Program (C. Berridge– advisor)

2013 - pres Ben Haehnel, Biophysics Training Program (B. Chanda - advisor)

Undergraduate Research Training:

2015 - pres Teja Karimikonda, Neuroscience 699, Independent Research Training

(Honors: “University of Wisconsin Sophomore Research Fellowship”)

2013- 2014 Stephen Emmerling, Neuroscience 699, Independent Research Training

2011 - 2013 Abby Schuh, Physiology 699, Independent Research Training (Papers:

coauthor one paper) Currently: Medical Student - Univ. Wisconsin

2009 – 2012 Lamin Manneh, Independent Research Training

2008 - 2009 Erik Vaklyes, Independent Research Training

2007 Heather Meiselman, Biology 335 – Entering research, independent

research training

2005 – 2007 Say Thao, Minority Summer Research Program, Independent Research

Training (Papers: coauthor of 2 abstracts)

2005 – 2006 Pedro Warff, Minority Summer Research Program, Independent Research

Training (Papers: coauthor of 1 abstract)

2003 - 2004 Whitney Pafford, Independent Research Training, Senior Honors Thesis

2002 - 2004 Jeremy Bushman, Independent Research Training (Honors: “2003 Pfizer

Fellowship for Undergraduate Research”)

2001- 2002 Ross McDermitt, Molecular Biology Program, Senior Honors Thesis

(Honors: “2001 Trewartha Undergraduate Research Grant” and

“Outstanding Undergraduate NeuroscienceThesis Award” Papers:

coauthor of 1 paper, 1 abstract)

2000 - 2002 James Clark, Dept of Chemical Engineering, Independent Study (Papers:

coauthor of 1 paper)

1997 - 2000 Lisa Ann Wheeler, Dept. of Bacteriology, Independent Study

1998 - 1999 Jeff Malik, Dept. of Zoology and Psychology, Independent Study

1997 - 1998 Amy Evers, Senior Honors Thesis, Molecular Biology Program (Honors:

“University Bookstore Academic Excellence Award” and “Outstanding

Undergraduate NeuroscienceThesis Award”; Papers: coauthor of 2

papers)

1997 - 1998 Peter Ward, Senior Honors Thesis, Molecular Biology Program, (Honors:

“1997 Trewartha Undergraduate Research Grant”; Papers: coauthor of 1

paper, 1 abstract)

1996 - 1997 Robert Chang, Honors Senior Thesis, Molecular Biology Program,

(Honors: “1996 Trewartha Undergraduate Research Grant”)

1996 - 1997 Amy Evers, Independent Study-GABAA Receptors,

1995 - 1996 Anson Davis, Senior Honors Thesis, Molecular Biology Program, Papers:

coauthor of 1 paper)

Summer ‘96 Joy Price, Visiting Minority Undergraduate Research Fellow

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1994 - 1995 Anson Davis, Independent Study - Ligand-Gated Ion Channels

Summer ‘95 Polo Chen, Medical Scholars Undergraduate Research Trainee, U. of

Wisconsin-Madison (Papers: 1 abstract)

Outreach Training:

2014 Teja Karimikonda, Summer Research Internship for High School students,

Madison Metropolitan School District

2015 - 2016 Bailey Connery, Wisconsin Youth Apprenticeship Program, educating

high school senior student in biotechnology.

PUBLICATIONS (primary journal articles)

1. Borden, L. A., CZAJKOWSKI, C., Chan, C. Y. and Farb, D. H. (1984)

Benzodiazepine receptor synthesis and degradation by neurons in culture. Science

226: 857-859.

2. Gibbs, T. T., Chan, C. Y., CZAJKOWSKI, C., and Farb, D. H. (1985)

Benzodiazepine receptor photoaffinity labeling: Correlation of function with

binding. Eur. J. Pharmacol. 110: 171-180.

3. CZAJKOWSKI, C. M. and Farb, D. H. (1986) Transmembrane topology and

subcellular distribution of the benzodiazepine receptor. J. Neurosci. 6:2857-2863.

4. CZAJKOWSKI, C., Gibbs, T. T., and Farb, D. H. (1989) Transmembrane

topology of the gamma-aminobutyric acidA/benzodiazepine receptor: Subcellular

distribution and allosteric coupling determined in situ. Mol. Pharmacol. 35:75-84.

5. CZAJKOWSKI, C. and Farb, D. H. (1989) Identification of an intracellular pool

of gamma-aminobutyric acidA/benzodiazepine receptors en route to the cell

surface of brain neurons in culture. Mol Pharmacol 35:183-188.

6. CZAJKOWSKI, C., DiPaola, M., Bodkin, M., Salazar-Jimenez, G., Holtzman, E.,

and Karlin A. (1989) The intactness and orientation of acetylcholine

receptor-rich membrane from Torpedo californica electric tissue. Arch. Biochem.

Biophys. 272:412-420.

7. DiPaola, M., CZAJKOWSKl, C., and Karlin, A. (1989) The sidedness of the

C-terminus of the acetylcholine receptor delta subunit. J. Biol. Chem. 264:

15457-15463.

8. CZAJKOWSKI, C. and Karlin, A. (1991) The agonist binding site of Torpedo

electric tissue nicotinic acetylcholine receptor: A negatively charged region of the

delta subunit within 0.9 nm of the alpha subunit binding site disulfide. J. Biol.

Chem. 266:22603-22612.

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9. CZAJKOWSKI, C., Kaufmann, C., and Karlin, A. (1993) Negatively charged

amino acid residues in the nicotinic receptor delta subunit that contribute to the

binding of acetylcholine. Proc. Natl. Acad. Sci. USA 90:6285-6289.

10. CZAJKOWSKI, C., and Karlin, A. (1995) Structure of the nicotinic receptor

acetycholine binding site: Identification of acidic residues in the delta subunit

within 0.9 nm of the alpha subunit binding site disulfide. J. Biol. Chem.

270:3160-3164.

11. Martin, M., CZAJKOWSKI, C., and Karlin, A. (1996) The contributions of

aspartyl residues in the acetylcholine receptor and subunits to the binding of

agonists and competitive antagonists. J. Biol. Chem. 271:13497-13503.

12. Krasowski, M.D., O’Shea, S. M., Rick, C. E., Whiting, P.J., Hadingham, K. L.,

CZAJKOWSKI, C., and Harrison, N. L. (1997) Alpha subunit isoform influences

GABAA receptor modulation by propofol. J. Neuropharmacol. 36(7): 941-949.

13. Boileau, A.J., Evers, A.R., Kucken, A.M. & CZAJKOWSKI, C. (1998)

Molecular dissection of benzodiazepine binding and allosteric coupling

using chimeric GABAA receptor subunits. Mol. Pharmacol. 53: 295-303.

14. Connor, J. X., Boileau, A. J., CZAJKOWSKI, C. (1998) GABAA receptor

1-EGFP fusion protein requires a subunit for functional surface

expression. J. Biol. Chem. 273:28906-28911.

15. Boileau, A.J., Evers, A. R., Davis, A. F. and CZAJKOWSKI, C. (1999)

Mapping the agonist binding site of the GABAA receptor: Evidence for a

beta-strand. J. Neurosci. 19: 4847-4854.

16. Boileau, A.J. and CZAJKOWSKI, C. (1999) Identification of transduction

elements for benzodiazepine modulation of the GABAA receptor: three

residues are required for allosteric coupling. J. Neurosci. 19: 10213-

10220.

17. Li, X., CZAJKOWSKI, C. and Pearce, R. A. (2000) Rapid and direct

modulation of GABAA receptors by halothane. Anesthesiology 92:1366-

1375.

18. Kucken, A. M., Wagner, D, Ward, P.,Teissére, J.A., Boileau, A.J. and

CZAJKOWSKI, C. (2000) Identification of Benzodiazepine Binding Site

Residues on the 2 Subunit of the GABAA Receptor. Mol. Pharmacol.

57:932-939.

19. Wagner, D. A. and CZAJKOWSKI, C. (2001) Structure and dynamics of

the GABA binding pocket: a narrowing cleft that constricts during

activation. J. Neurosci. 21:67-74

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20. Horenstein, J., Wagner, D.A., CZAJKOWSKI, C. and Akabas, M.H.

(2001) Protein mobility and GABA-induced conformational changes

detected in the GABA-A receptor channel-lining M2 segment. Nature

Neuroscience 4:477-485.

21. Teissére, J.A and CZAJKOWSKI, C. (2001) A -strand forms part of the

benzodiazepine binding site of the GABA-A receptor: Structural

rearrangements detected during channel activation. J. Neurosci. 21: 4977-

4986.

22. *Boileau, A.J., *Newel, J. G., CZAJKOWSKI, C. (2002) GABAA Receptor 2

Y97 and L99 Line the GABA Binding Site: Insights into Mechanisms of Agonist

and Antagonist Actions (* co-first authors). J. Biol. Chem. 277:2931-2937.

23. Holden, J. H. and CZAJKOWSKI, C. (2002) Different residues in the GABA-A

receptor 1T60-1K70 region mediate GABA and SR-95531 actions. J. Biol.

Chem. 277: 18785-18792.

24. Boileau, A.J., Baur, R., Sharkey, L. M., Sigel, E. & CZAJKOWSKI, C. (2002)

The relative amount of cRNA coding for [gamma]2 subunits affects stimulation

by benzodiazepines in GABAA receptors expressed in Xenopus oocytes.

Neuropharmacology 43: 695- 700.

25. *Bowser, D.N., *Wagner, D.A., CZAJKOWSKI, C., Cromer, B.A., Parker,

M.W., Wallace, R.H., Harkin,L.A., Mulley, J.C., Marini, C., Berkovic, S.F.,

Williams, D.A., Jones, M.V. and Petrou, S. (2002) Altered kinetics and

benzodiazepine sensitivity of a GABA-A receptor subunit mutation(-R43Q)

found in human epilepsy (* co-first authors). Proc. Natl. Acad. Sci. 99: 15170-

15175.

26. *Kucken, A.M., *Teissére, J.A., Seffinga-Clark, J., Wagner, D.A. and

CZAJKOWSKI, C. (2003) Structural requirements for imidazobenzodiazepine

binding to GABA-A receptors (* co-first authors). Mol. Pharmacol. 63: 289 -296.

27. Newell, J. G. and CZAJKOWSKI, C. (2003) The GABA-A receptor 1 subunit

Pro174-Asp191 segment is involved in GABA binding and channel gating. J.

Biol. Chem. 278:13166-13172.

28. Boileau, A.J., Li, T., Benkwitz, C, CZAJKOWSKI, C and Pearce, R.A. (2003)

Effects of 2S Subunit Incorporation on GABAA Receptor Macroscopic Kinetics.

Neuropharmacology 44: 1003-1012.1.

29. Wagner, D.A., CZAJKOWSKI, C., and Jones, M.V. (2004) An arginine involved

in GABA binding and unbinding but not gating of the GABA-A receptor. J.

Neurosci. 24: 2733-2741.

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30. Sancar, F. and CZAJKOWSKI, C. (2004) A GABA-A receptor mutation linked to

human epilepsy (2 R43Q) impairs cell surface expression of receptors. J.

Biol. Chem. 279: 47034-47039

31. Newell, J. G., McDevitt, R. A. and CZAJKOWSKI, C. (2004) Mutation of

Glutamate 155 of the GABAA Receptor 2 Subunit Produces a Spontaneously

Open Channel: A Trigger for Channel Activation. J. Neurosci. 24: 11226-11235.

(Paper was highlighted in “This Week in the Journal” in the December 15th issue

as a new and important paper in the field).

32. CZAJKOWSKI, C. (2005) Triggers for channel opening. Nature 438: 167-168.

33. Boileau, A.J., Pearce, R. A. and CZAJKOWSKI, C. (2005) Tandem subunits

effectively constrain GABA-A receptor stoichiometry and recapitulate receptor

kinetics but are insensitive to GABA-A receptor-associated protein. J. Neurosci.

25:11219-11230.

34. Mercado, J. and CZAJKOWSKI, C. (2006) Charged residues in the 1 and 2

pre-M1 regions involved in GABA-A receptor activation. J. Neurosci. 26:2031-

2040.

35. Muroi, Y., CZAJKOWSKI, C. and Jackson, M.B. (2006) Local and global ligand-

induced changes in the structure of the GABA-A receptor. Biochemistry 45: 7013-

7022.

36. Sancar, F., Ericksen, S.S., Kucken, A.M., Teissere, J.A. and CZAJKOWSKI, C.

(2007) Structural determinants for high affinity zolpidem binding to GABA-A

receptors. Mol. Pharmacol 71: 38-46. Epub 2006 Sep 29.

37. Kloda, J. H. and CZAJKOWSKI, C. (2007) Agonist-, antagonist-, and

benzodiazepine-induced structural changes in the 1Met113-Leu132 region of the

GABA-A receptor. Mol. Pharmacol 71: 483-493. Epub 2006 Nov 15.

38. Hanson, S. M. and CZAJKOWSKI, C. (2008) Structural mechanisms underlying

benzodiazepine modulation of the GABAA receptor. J. Neurosci. 28: 3490-3499.

PMCID: PMC2410040

39. Mercado, J. and CZAJKOWSKI, C. (2008) GABA and pentobarbital induce

different conformational rearrangements in the GABAA receptor 1 and 2 pre-

M1 regions. J. Biol. Chem. 283: 15250-15257. PMCID: PMC2397470 [Available

on 2009/05/30]

40. Sharkey, L. M. and CZAJKOWSKI, C. (2008) Individually monitoring ligand-

induced changes in the structure of the GABA-A receptor at benzodiazepine

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binding site and non-binding site interfaces. Mol. Pharmacol. 74: 1-10. PMCID:

PMC2552402 [Available on 2009/07/01]

41. Venkatachalan, S. and CZAJKOWSKI, C. (2008) A conserved salt-bridge critical

for GABAA receptor function and loop C dynamics. Proc. Natl. Acad. Sci. 105:

13604-13609. PMCID: PMC2533236

42. Hanson, S.M., Morlock, E.V., Satyshur, K.A., and CZAJKOWSKI, C. (2008)

Structural requirements for eszopiclone and zolpidem binding to the GABAA

receptor are different. J. Med. Chem. 51: 7243-7252. PMCID: PMC2645942

[Available on 2009/11/27]

43. Muroi, Y., Theusch, C.M., CZAJKOWSKI, C., and Jackson, M.B. (2009) Distinct

structural changes in the GABA-A receptor elicited by pentobarbital and GABA.

Biophysical Journal. 96: 499-509. PMCID: PMC2716461 (Paper was one of five

highlighted papers for the January 21st issue. Paper received a Faculty of 1000

Medicine citation

http://www.f1000medicine.com/article/sdbcckcvdv120fk/id/1157215).

44. Boileau, A.J., Pearce, R. A. and CZAJKOWSKI, C. (2010) The short splice

variant of the 2 subunit acts as an external modulator of GABAA receptor

function. J. Neurosci. 30: 4895-4903 PMCID: PMC2891256

45. Wagoner, K.R. and CZAJKOWSKI, C. (2010) Stoichiometry of Expressed

42 -aminobuytric acid type A receptors depends on the ratio of subunit

cDNA transfected. J. Biol. Chem. 285: 14187-14194 PMCID: PMC2863200

[Available on 2011/5/7]

46. Hanson, S.M. and CZAJKOWSKI, C. (2011) Disulfide trapping of the GABA-A

receptor reveals the importance of the coupling interface in benzodiazepine

action. British J. Pharmacol. 162:673-687. PMCID: PMC3041256

47. Sancar, F. and CZAJKOWSKI, C. (2011) Allosteric modulators induce distinct

movements at the GABA-binding site interface of the GABA-A receptor.

Neuropharmacology 60:520-528. PMCID: PMC3026633 [Available on 2012/2/1]

48. Dellisanti, C.D., Hanson, S.M., Chen, L. and CZAJKOWSKI, C. (2011) Packing

of the extracellular domain hydrophobic core has evolved to facilitate pentameric

ligand-gated ion channel function. J. Biol. Chem. 286: 3658-3670. PMCID:

PMC3030369 [Available on 2012/2/4]

49. Morlock, E. V. and CZAJKOWSKI, C. (2011) Different residues in the GABA-A

receptor benzodiazepine binding pocket mediate benzodiazepine efficacy and

binding. Mol. Pharmacol. 80: 14-22 PMCID: PMC3127544 [Available on

2012/7/1]

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50. Venkatachalan SP and CZAJKOWSKI, C. (2012) A structural link between the

GABA-A receptor’s agonist binding site and inner -sheet governs channel

activation and allosteric drug modulation. J. Biol. Chem. 287: 6714-6724

PMCID: PMC3307325

51. Ghosh, B. and CZAJKOWSKI, C. (2013) Propofol binding to the resting state of

the Gloeobacter violaceus ligand gated ion channel (GLIC) induces structural

changes in the inter and intra-subunit trans-membrane domain (TMD) cavities. J.

Biol. Chem. 288: 17420-17431.

52. Dellisanti, C.D., Ghosh, B. Hanson, SM, Raspanti, JM, Grant, VA, Diarra, GM,

Schuh, AM, Satyshur, K, Klug, CS and CZAJKOWSKI, C. (2013) Site-directed

spin labeling reveals pentameric ligand-gated ion channel gating motions. PLoS

Biol 11(11): e1001714. doi:10.1371/journal.pbio.1001714 (Paper highlighted in

editor’s weekly pick)

53. Laha, K.T., Ghosh, B and CZAJKOWSKI, C. (2013) Macroscopic Kinetics of

Pentameric Ligand Gated Ion Channels: Comparisons between Two Prokaryotic

Channels and One Eukaryotic Channel. PLoS ONE 8(11): e80322.

doi:10.1371/journal.pone.0080322

54. Ding, Y., Dellisanti, C., Ko, M., CZAJKOWSKI, C. and Puglielli, L. (2014) The

Er-Based Acetyltransferases, Atase1 And Atase2, Associate With The Ost

Complex To Acetylate Correctly Folded Polypeptides. Journal of Biological

Chemistry 289: 32044-32055 PMCID: PMC4231681

PUBLICATIONS (review articles and book chapters)

1. Farb, D. H., Borden, L. A., Chan, C. Y., CZAJKOWSKI, C., Gibbs, T. T., and

Schiller, G. D. (1984) Modulation of neuronal function through benzodiazepine

receptors: Biochemical and electrophysiological studies of neurons in primary cell

culture. Annals of the New York Academy of Sciences 435: 1-31.

2. Farb, D. H., CZAJKOWSKI, C. M., Borden, L. A., Schiller, G. D., and Gibbs, T.

T. (1986) Turnover of the benzodiazepine/GABA receptor complex determined

in situ. In: “Advances in Biochemical Psychopharmacology”. Eds.: Biggio, G. and

Costa, E. Raven Press, 51-66.

3. Andrew J. Boileau, Amy Kucken, Amy R. Evers and Cynthia CZAJKOWSKI

(1999) Molecular dissection of the GABAA receptor: The N-terminal domain of

the 2 subunit is essential for benzodiazepine binding and subunit assembly.

Peptides: Frontiers of Peptide Science, pp 508-511, Kluwer Academic Publishers,

The Netherlands.

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4. Newell, J. G. and CZAJKOWSKI, C (2005) Scanning Cysteine Mutagenesis:

Mapping Binding Sites of Ligand-gated Ion Channels (Chapter 21) in Handbook

of Neurochemistry and Molecular Biology, Vol 18. Abel Lajtha, Editor in Chief,

Published by Springer. New York, NY.

PUBLICATIONS (abstracts)

1. Borden, L. A., C. CZAJKOWSKI, and Farb, D. H. (1981) Distribution of GABA

transport sites in embryonic chick spinal cord neurons in cell culture. Soc.

Neurosci. Abstr. 7: 367.

2. CZAJKOWSKI, C. and Farb, D. H. (1983) Analysis of benzodiazepine receptor

turnover in cell culture by SDS gel electrophoresis. Soc. Neurosci. Abstr. 9: 365.

3. CZAJKOWSKI, C. and Farb, D. H. (1985) Evidence for cell surface and

sequestered benzodiazepine receptors in chick brain cell cultures. Soc. Neurosci.

Abstr. 11: 278.

4 CZAJKOWSKI, C. M., Mierlak, D., and Farb, D. H. (1986) Transmembrane

topology and distribution of the benzodiazepine receptor: Ro7-0213 as a probe for

cell surface receptors. Soc. Neurosci. Abstr. 12:664.

5. CZAJKOWSKI, C. M. and Farb, D. H. (1986) Subcellular distribution and

turnover of the benzodiazepine receptor in chick brain cell culture. J. Cell Biol.

Abstr. 103:375a.

6. Karlin, A., DiPaola, M., Kao, P., Wang, L., CZAJKOWSKI, C., Chak, A. (1988)

Functional sites of the nicotinic acetylcholine receptor. Puerto Rico Health

Science Journal, 7:75.

7. DiPaola, M., CZAJKOWSKI, C., Bodkin, M., and Karlin, A. (1988) The

C-terminus of the Torpedo acetylcholine receptor delta subunit is extracellular.

Soc. Neurosci. Abstr. 14:640.

8. CZAJKOWSKI, C. and Karlin, A. (1991) Mapping the negative subsite of the

nicotinic acetylcholine receptor agonist binding site. Soc. Neurosci. Abstr. 17:23.

9. CZAJKOWSKI, C., Kaufmann, C., and Karlin, A. (1992) Nicotinic receptor

delta subunit D180 and E189 contribute to the binding of acetylcholine. Soc.

Neurosci. Abst. 18: 597.

10. Karlin, A., Akabas, M.H., CZAJKOWSKI, C., Kaufmann, C., Stauffer, D. and

Xu, M. (1994) Structures involved in binding, gating, and conduction in

nicotinic acetylcholine receptors. Renal Physiol. Biochem. 17: 184-186.

11. Martin, M., CZAJKOWSKI, C. and Karlin, A. (1995) Acetylcholine receptor

gamma subunit ASP174 contributes to the binding of acetylcholine and curare.

Soc. Neurosci. Abst. 21:1583.

12. Boileau, A.J., Cozzi, N.V., Chen, P., and CZAJKOWSKI C. (1996)

Identification of GABA and Diazepam-responsive regions of the GABAA

receptor using 2/1 subunit chimeras. Soc. Neurosci. Abst. Vol. 22, Part 2, p.

1284.

13. O’Shea, S.M., Krasowski, M.D., Rick, C.E., Whiting, P.J., Hadingham, K.L.,

CZAJKOWSKI, C., and Harrison,N.L. (1996) Subunit-dependent modulation of

recombinant GABAA receptors by general anesthetics. Soc. Neurosci. Abst. Vol.

22, Part 2, p. 1289.

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14. Li, X, Banks, M., CZAJKOWSKI, C., and Pearce, R. A. (1997) Effect of

halothane on GABAA receptors studied using rapid application techniques.

American Society of Anesthesiologists Annual Meeting October 1997, San

Diego, CA.

15. Li, X.S., CZAJKOWSKI, C., and Pearce R.A. (1997) Patch excision alters

responses of expressed GABAA receptors to halothane. Soc. Neuroscience

Abstracts 23:104.

16. Boileau, A.J., Kucken, A.M. & CZAJKOWSKI, C. (1997) Uncoupling of GABA

and benzodiazepine responsive regions of the GABAA receptor using 2

subunit chimeras. Soc. Neurosci. Abstr., Vol. 23, Part 1, p. 951

17. Connor, J. X., Boileau, A.J. & CZAJKOWSKI, C. (1997) GABAA 1/EGFP

fusion protein requires a subunit for functional surface expression. Soc.

Neurosci. Abstr., Vol. 23, p. 112

18. Boileau, A.J. & CZAJKOWSKI, C. (1999) Uncoupling of BZD binding from

potentiation: Identification of GABAA receptor domains required for BZD

allosteric modulation. Soc. Neurosci. Abstr., Vol. 25, Part 1, p. 964.

19. Kucken, A.M., Teissére, J.A., Wagner D.A., Boileau A.J. & CZAJKOWSKI, C.

(1999) Identification of benzodiazepine binding site residues in the 2 subunit of

the GABAA receptor. Soc. Neurosci. Abstr., Vol. 25, Part 1, p. 964.

20. Teissére, J.A., Boileau, A.J. & CZAJKOWSKI, C. (1999) Elucidating the

structure of the benzodiazepine binding site on the GABAA receptor by

engineered sulfhydryl modification. Soc. Neurosci. Abstr., Vol. 25, Part 1, p. 964.

21. Holden, J.H., Boileau, A.J., Teissére, J.A., Wagner, D.A. & CZAJKOWSKI, C.

(1999) Mapping the agonist binding site of the GABAA receptor: Evidence for a

beta-strand. Soc. Neurosci. Abstr., Vol. 25, Part 1, p. 459.

22. Horenstein, J., Wagner, D.A., CZAJKOWSKI, C. & Akabas, M.H. (1999)

Relative mobility of the GABAA receptor M2 membrane-spanning segments

inferred by disulfide trapping. Soc. Neurosci. Abstr., Vol. 25, Part 2, p. 1712

23. Wagner, D.A., and CZAJKOWSKI, C. (2000) Cysteine mutagenesis of the V199

– S209 region of the GABA-A 2 subunit reveals a mobile domain of the GABA

binding pocket. Soc. Neurosci. Abstr.

24. Holden, J.H., Boileau, A.J. and CZAJKOWSKI, C. (2000) Characterization of

1F64, 1R66, and 1S68 of the GABA-A receptor:Their roles at the GABA

binding site. Soc. Neurosci. Abstr.

25. Teissere, J.A., Kucken, A.M., Wagner, D.A., Wheeler, L. and CZAJKOWSKI C.

(2000) A new model for orientation of class III ligands in the benzodiazepine

binding pocket of the GABA-A receptor. Soc. Neurosci. Abstr.

26. Banks, M.I., Saad, A.A., Czajkowski, C.M., and Pearce, R.A. (2001) Subunit-

specific modulation of recombinant GABA-A receptors by isoflurane. American

Society of Anesthesiologists Annual Meeting.

27. Holden, JH and CZAJKOWSKI C. (2001) Mapping agonist and antagonist

binding site subdomains in the 1M113-T125 region of the GABA-A receptor.

Soc. Neurosci. Abstr.

28. Newell, JG and CZAJKOWSKI, C (2001) Mutational analysis reveals the

importance of a novel domain of the GABA-A receptor 1 subunit for

agonist/antagonist binding. Soc. Neurosci. Abstr.

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29. Wagner, D.A. CZAJKOWSKI, C. and Jones, M.V. (2002) A putative binding

pocket residue in the GABA-A receptor selectively mediates unbinding kinetics

but not channel gating. Biophys J. 82:257a, poster# 1244.

30. Wagner, D.A., Bowser, D.N., CZAJKOWSKI, C., Cromer, B.A., Berkovic, S.F.,

Williams, D.A., Petrou, S. and Jones, M.V. (2002) The GABA-A receptor

mutation2(R43Q), found in humans with epilepsy, slows current decay and

increases desensitization. American Epilepsy Society Abstr. 2.042

31. Wagner, D.A., CZAJKOWSKI, C.M., Jones, M.V. (2002) Arginine 207 of the

beta2 subunit of the GABA-A receptor selectively mediates unbinding kinetics

but not channel gating. Soc. Neurosci. Abstr. 40.6.

32. Newell, J.G., McDevitt, R.A. and CZAJKOWSKI, C (2002) Mutation of a

GABA-A receptor bindng site residue produces a constitutively open channel.

Soc. Neurosci. Abstr. 40.3.

33. Sharkey, L.M. and CZAJKOWSKI, C (2002) Evidence that the two subunit

interfaces ( and ) of the GABA-A receptor are structurally different and

play different roles in receptor function. Soc. Neurosci. Abstr. 40.4.

34. Holden, J.H. and CZAJKOWSKI, C. (2002) Identification of residues involved in

allosteric crosstalk between the GABA and benzodiazepine binding sites. Soc.

Neurosci. Abstr. 40.2.

35. Kucken, A.M. and CZAJKOWSKI, C. (2002) GABA-A receptor binding site

structure examined by intermolecular thiol cross-linking. Soc. Neurosci. Abstr.

40.1.

36. Boileau, A.J., Pearce, R.A. and CZAJKOWSKI, C (2002) Heterologous

expression of GABAA receptor subunits: What are we really making? Presented

at: GABA-A Receptors in Cellular and Network Excitability, Satellite symposium

of the 2002 Annual Meeting of the Society for Neuroscience, Orlando, Oct 31 -

Nov 2.

37. Sancar, F. and CZAJKOWSKI, C (2003) A GABA-A receptor mutation linked to

human epilepsy (2 R43Q) impairs receptor expression. Soc. Neurosci. Abstr.

38. Mercado, J. L. and CZAJKOWSKI, C (2003) Charged residues in the pre-M1

region of the GABA-A receptor play a role in coupling binding to gating. Soc.

Neurosci. Abstr.

39. Holden, J.H. and CZAJKOWSKI, C. (2003) 1Gly124-1Leu132: A novel binding

site region on the GABA-A receptor that undergoes distinct conformational

rearrangements during ligand binding and allosteric modulation. Soc. Neurosci.

Abstr.

40. Sharkey, L.M. and CZAJKOWSKI, C (2004) Asymmetric movements in the 1

and 2 subunits of the GABA-A receptor during channel gating. Biophysical Soc.

Abstr.

41. Kucken, A.M. and CZAJKOWSKI, C. (2004) GABA-A receptor binding site

dynamics examined by intermolecular thiol crosslinking. Soc. Neurosci. Abstr.

42. Sharkey, L.M. and CZAJKOWSKI, C (2004) 1V107-T112: A region that links

the GABA-A receptor’s BZD and GABA binding sites. Soc. Neurosci. Abstr.

43. Muroi, Y., Boileau, A.J., CZAJKOWSKI, C and Jackson, M.B. (2004)

Fluorescence probing of conformational transitions in the extacellular domain of

the GABA-A receptor. Soc. Neurosci. Abstr.

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44. Venkatachalan S., Sharkey L and CZAJKOWSKI C. (2005) Disruption of 2

K102-T110, a region that links the GABA-A receptor’s agonist binding site to the

inner -sheet domain, impairs channel activation. Gordon conference “Inhibition

in the Brain” July 2005.

45. Sancar F., Kucken A.M., Teissere J.A. and CZAJKOWSKI, C. (2005)

Determinants of high affinity zolpidem binding in the 2 subunit of the GABA-A

receptor. Soc. Neurosci. Abstr.

46. Theusch, CM and CZAJKOWSKI, C (2005) Mutation of M55 in the GABAA

receptor -induced activation. Soc. Neurosci.

Abstr.

47. Muroi Y, Boileau A J., CZAJKOWSKI C, and Jackson M. B. (2005) Agonists,

antagonists, and allosteric modulators produce different structural changes in the

GABAA receptor Soc. Neurosci. Abstr.

48. Venkatachalan S., Thao, S, Warff, P. and CZAJKOWSKI, C. (2006)

Identification of a 2 intra-subunit salt bridge critical for GABA-A receptor

activation. Biophysical Society Meeting, Biophys J. 90: 2629

49. Mercado, J. L. and CZAJKOWSKI, C (2007) GABA and pentobarbital induce

different conformational rearrangements in the 1 and 2 pre-M1 regions of the

GABAA receptor. Biophysical Society Meeting

50. Kucken, A.M. and CZAJKOWSKI C (2007) Motion of the GABA-A receptor

loop C binding site region. Soc. Neurosci. Abstr.

51. Hanson, S.M. and CZAJKOWSKI, C (2007) Loop F of the GABA-A receptor

gamma2 subunit is a determinant for benzodiazepine efficacy. Soc. Neurosci.

Abstr.

52. Theusch, C.M., Muroi, Y., CZAJKOWSKI, C. and Jackson, M (2007)

Pentobarbital-induced structural changes in the GABA-A receptor. Soc. Neurosci.

Abstr.

53. Mercado, J. and CZAJKOWSKI, C. (2007) Dynamics of the GABA-A receptor

beta2 Loop 9. Soc. Neurosci. Abstr.

54. Venkatachalan, S. and CZAJKOWSKI, C. (2007) Disruption of 2 K102-T110, a

region that links the GABA-A receptor’s agonist binding site to the inner b-sheet

domain, impairs channel activation. Soc. Neurosci. Abstr.

55. Venkatachalan, S., Thao, S. and CZAJKOWSKI, C. (2008) An intrasubunit salt-

bridge linking Loop A and Loop 2 is critical for GABA-A receptor activation.

Biophysical Society Meeting

56. Hanson, S.M., Morlock, E.V., Satyshur, K.A., and CZAJKOWSKI, C. (2008)

Defining the pharmacophore for eszopiclone and zolpidem in 1-containing

GABAA receptors. Society for Neuroscience Annual Meeting, Washington, D.C.,

2008.

57. Raspanti, J. and CZAJKOWSKI, C. (2008) Benzodiazepine association and

dissociation binding kinetics to the GABA-A receptor. 18th Neuropharmacology

conference ‘Ligand-gated ion channels’, Washington, D.C., 2008.

58. Christopherson, K. R. and CZAJKOWSKI, C. Using the alpha-bungarotoxin

binding site tag to determine stoichiometry of alpha4-beta2-delta GABA-A

receptors. 18th Neuropharmacology conference ‘Ligand-gated ion channels’,

Washington, D.C., 2008.

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59. Theusch, CM, Hernandez, LH, Boileau, AJ, Jackson, MB, and CZAJKOWSKI, C

(2008) Voltage clamp fluorometry reveals M2 -helix conformational changes in

-aminobutyric acid receptor-type A 1 and 2 subunits. Society for Neuroscience

Annual Meeting, Washington, D.C., 2008, abstract 530.9.

60. Venkatachalan, S., Zimprich, C, Los, G.V. and CZAJKOWSKI, C. Live cell

imaging of mutant and wild-type GABA-A receptor trafficking using a novel

reporter protein. Society for Neuroscience Annual Meeting, Washington, D.C.,

2008.

61. Theusch, CM, Jackson, MB, and CZAJKOWSKI, C (2009) Site-specific

fluorescence reveals GABA-induced structural movements near the extracellular

end of the pore-lining M2 -helices of the GABA-A receptor. Biophysical

Society Meeting

62. Ghosh, B. and CZAJKOWSKI, C (2009) Mapping structural changes in the

GABAA receptor transmembrane domain using site-specific fluorescent labeling.

Society for Neuroscience Annual Meeting, Chicago, IL, 2009

63. Hanson, SM and CZAJKOWSKI, C (2009) Disulfide trapping of the GABA-A

receptor reveals the importance of the coupling interface in benzodiazepine

modulation. Society for Neuroscience Annual Meeting, Chicago, IL, 2009

64. Raspanti, J and CZAJKOWSKI, C (2009) Allosteric interactions between the

benzodiazepine and GABA binding sites of the GABAA receptor. Society for

Neuroscience Annual Meeting, Chicago, IL, 2009

65. Christopherson, KR and CZAJKOWSKI, C (2009) Stoichiometry of

42GABAA receptors expressed in HEK293T cells. Society for Neuroscience

Annual Meeting, Chicago, IL, 2009

66. Morlock, EV and CZAJKOWSKI, C (2009) Defining residues involved in the

efficacy of benzodiazepine modulation of GABAA receptor current. Society for

Neuroscience Annual Meeting, Chicago, IL, 2009

67. Ghosh, B., Hanson, SM and CZAJKOWSKI, C (2010) Mutational analysis of the

prokaryotic pentameric ligand-gated ion channel GLIC. Biophysical Society

Meeting

68. Dellisanti, CD, Hanson, SM, Chen, L and CZAJKOWSKI, C (2010) Packing of

the extracellular domain hydrophobic core is evolutionarily optimized to facilitate

pentameric ligand-gated ion channel activation. Biophysical Society Meeting

69. Morlock, EV and CZAJKOWSKI, C (2010) Defining residues involved in the

efficacy of benzodiazepine modulation of GABAA receptor current. Society for

Neuroscience Annual Meeting, San Diego, CA, 2010

70. Ghosh, B. and CZAJKOWSKI, C (2011) Mapping anesthetic induced

movements in the prokaryotic ligand-gated ion channel GLIC. Society for

Neuroscience Annual Meeting, Washington, DC, 2011

71. Dellisanti, C and CZAJKOWSKI, C (2011) Site-directed spin labeling reveals

pentameric ligand-gated ion channel gating motions. Society for Neuroscience

Annual Meeting, Washington, DC, 2011

72. Laha, KT and CZAJKOWSKI, C (2012) Prokaryotic ligand gated ion channels

exhibit distinct kinetic properties compared to the related eukaryotic cys-loop

receptors. Society for Neuroscience Annual Meeting, New Orleans, LA, 2012

73. Ghosh, B. and CZAJKOWSKI, C (2013) Propofol induced structural changes in

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the TMD of the prokarylotic pLGIC GLIC. Biophysical Society Meeting

74. Ghosh, B. and CZAJKOWSKI, C (2013) Allosteric modulators induce

asymmetric motions in the inter- and intra-subunit TMD cavities of GABAARs.

Society for Neuroscience Annual Meeting, 2013

75. Ghosh, B., Tiwari, V and CZAJKOWSKI, C (2014) Construction and

characterization of a functional GLIC-GABArho ligand-gated ion channel

chimera. Biophysical Society 58th Annual Meeting

76. Dellisanti, C and CZAJKOWSKI, C (2014) Loose packing of the extracellular

domain core of pentameric ligand-gated ion channels is important for fast

activation and desensitization. Biophysical Society 58th Annual Meeting

77. Ghosh, B. Tsao, T. and CZAJKOWSKI C (2014) Allosteric modulation of

GABA-A receptors by different drugs. Biophysical Society 58th Annual Meeting

78. Teusch, C and CZAJKOWSKI C (2015) Disulfide trapping the GABA-A

receptor extracellular beta-5/beta-5' loop. Biophysical Society 59th Annual

Meeting

79. Tsao, T, Ghosh, B and CZAJKOWSKI C (2015) Monitoring motions in GABA-A

receptor intersubunit transmembrane cavities. Biophysical Society 59th Annual

Meeting

80. Tiwari, V, Schuh A., Klug, C. and CZAJKOWSKI C (2016) Radial tilting of the

extracellular domain of GLIC revealed by EPR spectroscopy Biophysical Society

60th Annual Meeting

MANUSCRIPTS IN PREPARATION

1. Kucken, A.M. and CZAJKOWSKI, C. GABA-A receptor binding site dynamics

examined by intermolecular thiol crosslinking.

2. Tsao, T, Ghosh, B and CZAJKOWSKI C. Monitoring drug-induced motions in

GABA-A receptor intersubunit transmembrane cavities.

3. Theusch, CM, Jackson, MB, and CZAJKOWSKI, C. Site-specific fluorescence

reveals GABA-induced structural movements near the extracellular end of the

pore-lining M2 -helices of the GABA-A receptor.

4. Tiwari, V, Klug, C. and CZAJKOWSKI C. Radial tilting of the extracellular

domain of GLIC revealed by EPR spectroscopy.

5. Ghosh, B., Tiwari, V and CZAJKOWSKI, C. Construction and characterization of

a functional GLIC-GABArho ligand-gated ion channel chimera.

INVITED RESEARCH PRESENTATIONS

1993 Einstein University, School of Medicine, Dept. of Anatomy

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1993 University of Miami, Dept. of Physiology

1993 Cornell University, School of Medicine, Dept. of Pharmacology

1993 University of Chicago, Depts. of Anesthesiology and Pharmacology

1993 University of Vermont, School of Medicine, Dept. of Physiology

1993 University of Wisconsin, School of Medicine, Dept. of Neurophysiology

1994 Cornell University, School of Medicine, Dept. of Physiology

1996 Vanderbilt University, Department of Pharmacology, School of Medicine

1997 The American Peptide Symposium, Nashville, TN, invited symposium speaker

1998 Burroughs Wellcome Fund “1998 New Investigators Meeting” Invited Speaker

1998 University of Chicago, Dept. of Anesthesia & Critical Care and Dept. of

Physiology

1999 Winter Brain Conference, Invited Panel Speaker on GABAA receptors

1999 University of Alberta, Edmonton, Canada, Department of Pharmacology and

Division of Neuroscience

1999 University of Vermont, School of Medicine, Department of Biochemistry

2000 Boston University, Department of Pharmacology and Experimental Therapeutics

2000 University of Utah, Department of Neuroscience

2001 Winter Brain Conference, Invited Panel Speaker on GABAA receptors

2001 University of Puerto Rico in Cayey, RISE Program

2001 Ponce School of Medicine – Puerto Rico, Graduate program

2001 Pontificia Universidad Catolica de Puerto Rico, NIH Marc Honor Program

2001 University of Alabama, Neurobiology Seminar Program

2001 Marquette University, Dept. of Chemistry

2002 University of Colorado Health Sciences Center, Dept. of Pharmacology

2002 National Institutes of Health, NIAAA, Invited Symposium Speaker on Ion

Channel Structure/Function

2002 State University of New York, Health Science Center at Brooklyn, Department of

Physiology

2003 Louisiana State University, School of Medicine, Center for Neuroscience

2003 Neurion, Pasadena, CA (private company interested in targeted drug development

for ion channels)

2004 Biophysical Society Annual Meeting, Invited Symposium Speaker on Ion Channel

Gating

2004 Gordon Research Conference on Ligand Recognition and Molecular Gating,

Invited Symposium Speaker

2004 College de France, Paris, France, Distinguished Lectureship

2004 Merck Sharpe & Dohme, Harlow, Essex – England, Invited speaker on the

contribution of LGIC structure to channel function

2004 UCLA, Invited speaker in GABA-A receptor symposium

2004 College of London, School of Pharmacy

2004 University of Chicago, Neurobiology Seminar Series

2004 Gordon Research Conference on Ion Channels, Invited Panel Speaker

2004 University of Iowa, Department of Pharmacology and Neuroscience

2005 American Society of Neurochemisty, Invited Host Committee/Organizer, declined

2005 20th Biennial Meeting Int. Soc. Neurochem. & the European Soc. for

Neurochem.,Vienna – Austria Invited Symposium Speaker

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2005 Gordon Research Conference on Inhibition in the CNS, Invited Panel Speaker

2005 Tufts Medical School, Department of Neuroscience

2006 Sepracor, Marlborough, MA

2007 Emory University, Neuroscience Program

2007 University of Chicago, Neurobiology Seminar Series

2007 Gordon Research Conference on Inhibition in the CNS, Invited Panel Speaker

2007 State University of New York at Buffalo, Dept. of Physiology and Biophysics

2008 Washington University School of Medicine, Dept. of Anesthesiology

2008 University of North Carolina at Chapel Hill, Neuroscience Center

2008 Neuropharmacology Satellite Meeting “Ligand-gated Ion Channels”, Invited

symposium speaker (satellite meeting at Society of Neuroscience Annual

Meeting)

2009 Biochemical Society Focused Meeting “Neuronal glutamate and GABA(A)

receptor function in health and disease”, St. Andrews, Scotland, UK, Invited

Speaker

2009 Journal of Physiology Symposium “Advances and hold-ups in the study of

structure, function and regulation of Cys-loop ligand-gated ion channels and

receptors”, Chicago, Invited Speaker (satellite meeting at Society of

Neuroscience Annual Meeting)

2010 Gordon Research Conference on Ion Channels, Invited Panel Speaker

2010 Promega Corporation, Madison, WI, Invited Speaker

2010 GABA 2010, San Servolo, Italy, Invited Symposium speaker, declined

2010 Mechanisms of Anesthesia Conference, Toronto, Canada, Invited Symposium

speaker

2011 University of Copenhagen, Denmark, Department of Medicinal Chemistry

PHARMA

2011 Ligand-gated Ion Channel Symposium, Montreal, Canada, Invited Symposium

speaker

2011 Medical College of Wisconsin, Department of Biophysics

2012 Biophysical Society Annual Meeting, Chair and Organizer of Minisymposium on

“Ligand-gated Ion Channels”.

2012 The University of Texas Medical School, Center for Membrane Biology

2013 Gordon Research Conference on Inhibition in the CNS, Invited Panel Speaker

2013 Morani College of Medicine, University of South Florida, Mol. Pharmacol. and

Physiol. Department

2013 Texas Tech University Health Sciences Center, Lubbock, TX, Department of Cell

Physiology and Molecular Biophysics

2014 Gordon Research Conference on Ion Channels, Invited Panel Speaker

2014 Frontiers in Membrane Protein Structural Dynamics Conference, Chicago, IL,

Invited Speaker

2014 Dart Neuroscience, San Diego, CA, Invited speaker

2014 Barrow Neurological Institute, Phoenix, AZ, invited speaker

2015 9th IBRO World Congress, Rio de Janeiro, Brazil, invited speaker

2015 Polish Neuroscience Society Congress, Gdansk, Poland, invited speaker

2016 Biophysical Society Annual Meeting, Speaker and Co-chair, Ligand-gated Ion

Channel Session

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2016 UCSD, invited speaker

2016 10th Conference on Electrophysiological Techniques: From Ion Channels to

Neural Networks Krakow, Poland, invited speaker

2017 Biophysical Society - Emerging Concepts in Ion Channel Biophysics Mexico City,

Mexico, invited speaker

2017 Case Western Reserve University - Dept. of Physiology and Biophysics, invited

speaker

UNIVERSITY OF WISCONSIN PRESENTATIONS

1994 MD/PhD training program

1994 Neuroscience training program

1996 MD/PhD training program

1996 Department of Neurophysiology

1997 Promega - Second UW Madison Neuroscience Retreat, invited speaker

1997 Chemistry and Biology Interface Training Program

1997 Department of Pharmacology

1998 UW/HHMI 1998 Summer Conference: New Approaches to Membrane Protein

Structure and Function: Invited Speaker.

1999 Life Sciences Careers Day, invited speaker

2000 Department of Physiology

2001 MD/PhD training program

2005 Department of Physiology

2014 Department of Neuroscience

EXTRAMURAL RESEARCH SUPPORT - ACTIVE

1. Agency: NIH, NINDS (NS34727-16)

Role: Principal Investigator

Dates: 03/01/13 – 02/28/2017

Award: $325,000.00/ year (total direct costs)

Title: Structure of the GABAA receptor binding sites.

2. Agency: NIH/NINDS

Type: R21 - NINDS

Period: 12/01/2016 - 11/30/2018

Award: $ 275,000 direct costs

Submitted: Feb. 2016

Review Date: June 2016

Title: Endogenous Benzodiazepines in the Brain

EXTRAMURAL RESEARCH SUPPORT - PENDING

1. Agency: NIH, NINDS (NS34727-COMPETITIVE RENEWAL)

Role: Principal Investigator

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Dates: 03/01/17 – 02/28/2022

Award: $325,000.00/ year (total direct costs)

Title: Pentameric Ligand Gated Ion Channel Activation and Drug

Modulation.

Submitted: July 2016

2. Agency: NIH - NINDS

Type: F31 individual NRSA

Role: mentor for graduate student Jennifer Borchardt

Award: stipend for three years

Submitted: August 2016

EXTRAMURAL RESEARCH SUPPORT - COMPLETED

1. Agency: NIH, NINDS (NS34727)

Role: Principal Investigator

Dates: 03/15/12 - 02/28/2013 (bridge award)

Award: $385,469.00/ year (total direct costs)

Title: Structure of the GABAA receptor binding sites.

2. Agency: NIH, NINDS (NS059854)

Role: Principal Investigator

Dates: 02/15/2008 – 03/31/2013

Award: $218,750.00/ year (total direct costs)

Title: Structural Rearrangements in GABA-A Receptors.

3. Agency: NIH-NINDS predoctoral NRSA Award (F31-NS071995)

Role: Project Director (Elaine Morlock - pre-doctoral recipient)

Dates: 07/01/10 – 06/30/12

Award: $27,2058.00/ year

Title: “Structural elements involved in GABA-A receptor kinetics”

1. Agency: NIH, NINDS (NS34727)

Role: Principal Investigator

Dates: 01/01/08 - 11/30/2011

Award: $218,750.00/ year (total direct costs)

Title: Structure of the GABAA receptor binding sites.

2. Agency: Sepracor (ESRC104)

Role: Principal Investigator

Dates: 08/01/07 – 07/31/10

Award: $342,766.00 (total direct + indirect costs)

Title: Structural requirements for zolpidem and eszopiclone binding to

GABA-A receptors

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3. Agency: NIH, NINDS (NS34727-S)

Role: Principal Investigator

Dates: 09/01/09 - 08/31/2011

Award: $125,000.00/ year (total direct costs)

Title: “ARRA competitive supplement for “Structure of the GABA-A

Receptor Binding Sites”

3. Agency: NIH-NIAAA predoctoral NRSA Award (F31-AA016898)

Role: Project Director (Kelly Christopherson - pre-doctoral recipient)

Dates: 07/01/07 – 06/30/10

Award: $27,2058.00/ year

Title: “Mapping the putative ethanol binding site on 42 GABA-A

receptors”

4. Agency: NSF Graduate Research Fellowship award

Role: Project Director (Valerie Grant - pre-doctoral recipient)

Dates: 09/01/09 – 08/31/12

Award: $30,000/ year

5. Agency: NIH, NINDS (NS34727)

Role: Principal Investigator

Dates: 12/01/03 - 11/30/2007

Award: $250,000.00/ year (total direct costs)

Title: Structure of the GABAA receptor binding sites.

6. Agency: NIH, NIMH (MH66406)

Role: Principal Investigator

Dates: 07/01/02 – 06/30/07

Award: $200,000.00/ year (total direct costs)

Title: Benzodiazepine modulation of GABA-A receptor kinetics

7. Agency: Alcohol Beverage Medical Research Association

Role: Principal Investigator (5% salary)

Dates: 01/01/07 - 12/30/08

Award: $50,000.00/ year (total direct costs)

Title: Mapping the ethanol binding site on 42 GABA-A receptors

8. Agency: NIH-NIMH postdoctoral NRSA Award (MH082504)

Role: Project Director (Dr. Susan Hanson - post-doctoral recipient)

Dates: 09/30/07 – 09/29/09

Award: $49,646.00/ year

Title: “Structural requirements for benzodiazepine modulation of

GABA-A receptors”

9. Agency: NIH, NIGMS, R01

Role: Collaborator (5% salary)

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Dates: 07/01/02 - 06/30/06

Title: Volatile Anesthetic Actions on Synaptic GABA-A receptors

P.I. Robert A. Pearce, M.D., Ph.D

10. Agency: NIH, NINDS (NS34727)

Role: Principal Investigator

Dates: 12/01/99 - 11/30/03

Award: $190,000.00/ year (total direct costs)

Also received an additional $50,000.00 supplementary equipment

grant

Title: Structure of the GABAA receptor binding sites.

11. Agency: National Alliance for Schizophrenia and Affective Disorders

Role: Project Director

Dates: 9/15/01 - 9/14/03

Title: Mapping The GABA-A receptor: Molecular determination of

binding sites for psychotherapeutic agents

Award: $50,000/year

12. Agency: Epilepsy Foundation of America

Role: Project Director (Feyza Sancar - pre-doctoral recipient)

Dates: 07/01/03 - 06/30/04

Award: $16,000

Title: Role of GABA-A receptors in epilepsy: Characterization of three

mutations in the GABA-A receptor that are linked to human

epilepsy.

13. Agency: Pharmaceutical Research and Manufacturers of America

Role: Project Director (Jessica Holden - pre-doctoral recipient)

Dates : 01/01/01 – 12/31/02

Award: $12,500/ year

Title: “Mapping the GABA binding site on the GABA-A receptor”

14. Agency: NSERC – Canada (Postdoctoral Award)

Role: Project Director (Dr. Glen Newell - post-doctoral recipient)

Dates: 12/1/00 - 12/1/02

Award: $70,000/ 2 years

15. Agency: Burroughs Wellcome Fund

Role: Principal Investigator

Dates: 07/01/96 - 06/30/01

Award: $195,000

Title: Molecular determination of the benzodiazepine and GABA

binding sites of the GABAA Receptor

16. Agency: NIH-NINDS predoctoral NRSA Award

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Role: Project Director (Jeremy Teissere - pre-doctoral recipient)

Dates: 12/1/00 - 12/1/02

Award: $16,000/ year

Title: “Mapping benzodiazepine binding sites on GABA-A receptors”

17. Agency: NIH-NINDS NRSA Award

Role: Project Director (Dr. David Wagner - post-doctoral recipient)

Dates: 3/1/98 - 3/1/01

Award: $24,292.00/ year

Title: “Assembly of GABA-A Receptor Subunits”

18. Agency: NIH, NINDS, R01

Role: Principal Investigator

Dates: 12/01/96 - 11/30/99

Award: $565,940 (total direct costs)

Title: Structure of the GABAA receptor binding sites.

19. Agency: March of Dimes Foundation- Basil O’Conner Award

Role: Principal Investigator

Dates: 02/01/96 - 01/31/98

Award: $80,000

Title: Mapping the GABAA receptor: Molecular determination of

binding sites for psychotherapeutic agents.

20. Agency: Alcoholic Beverage Medical Research Foundation

Role: Principal Investigator

Dates: 06/01/96 - 05/31/98

Award: $79,996

Title: Mapping an alcohol antagonist binding site on the GABAA

receptor.

21. Agency: Epilepsy Foundation of America

Role: Principal Investigator

Dates: 07/01/96 - 06/30/97

Award: $29,983

Title: Molecular Recognition of Anti-Epileptic Drugs.

22. Agency: NIH-NINDS predoctoral NRSA Award (F31-NS071995)

Role: Project Director (Elaine Morlock - pre-doctoral recipient)

Dates: 07/01/10 – 06/30/12

Award: $27,2058.00/ year

Title: “Structural elements involved in GABA-A receptor kinetics”

INTRAMURAL RESEARCH SUPPORT – ACTIVE

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1. Agency: UW-Madison (Office of the Provost and SMPH Dean’s office)

Role: Awardee

Dates: 7/1/2012 - 6/30/2017

Award: $75,000 (total) funding is distributed throughout the award period

Title: Vilas Distinguished Achievement Professor

2. Agency: UW-Madison - WISELI

Role: Awardee

Dates: 07/01/2015 - 06/30/2016

Award: $40,000

Title: Vilas Life Cycle Professorship

3. Agency: UW-Madison - Graduate School Fall Competition

Role: Awardee

Dates: 07/01/2016 - 6/30/2017

Award: $48,414.00

Title: Structural basis of benzodiazepine recognition

INTRAMURAL RESEARCH SUPPORT - COMPLETED

1. Agency: UW-Madison School of Medicine/Howard Hughes Medical

Institute

Role: Faculty Investigator

Dates: 11/01/99 - 11/31/01

Award: $30,000

Title: UW/HHMI Program in Molecular Mechanisms of Disease – Pilot

Project

2. Agency: UW-Madison School of Medicine/Howard Hughes Medical

Institute

Role: Faculty Investigator

Dates: 03/01/96 - 12/31/97

Award: $50,000

Title: UW/HHMI Career Development Program in Molecular

Mechanisms of Disease

3. Agency: Univ. of Wisconsin Foundation – Graduate School

Role: Principal Investigator

Dates: 07/01/96 - 06/30/97

Award: $15,750

Title: Fundamental studies of the GABAA receptor.

4. Agency: Univ. of Wisconsin Foundation – Graduate School (WARF)

Role: Principal Investigator

Dates: 07/01/07 - 06/30/08

Award: $34,266

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Title: Structural Rearrangements in GABA-A receptors

5. Agency: University of Wisconsin - School of Medicine and Public

Health

Role: Principal Investigator

Dates: 07/01/07 - 06/30/08

Award: $23,470

Title: Structural Rearrangements in GABA-A receptors

6. Agency: University of Wisconsin – MERC - WID

Role: Collaborator

Dates: 07/01/07 - 06/30/09

Award: $9,191.00/yr

Title: A novel method for high-throughput drug screening of ligand-

activated ion channels based on tethered ligand force measurement

SERVICE – UNIVERSITY

2016 - 2019 Member, Academic Planning Council, UW - Graduate School (meets

monthly)

2013 - 2017 Member, UW – Graduate Faculty Executive Committee (meets monthly -

conducts and approves graduate program reviews, approves new graduate

programs, reviews and decides graduate student learning goals, stipends)

2016 - 2019 Member, Space Committee, UW - SMPH (meets monthly)

2016 - Peer Mentor, faculty mentor for new Assistant Professor, Darci Moore,

Department of Neuroscience, UW-SMPH

2016 - 2017 Faculty Coordinator, Department of Neuroscience Fall and Spring

Seminar Series

2016 Member, Search Committee, Associate Dean of UW - Graduate School

2015 - 2016 Member, Department of Neuroscience, Faculty Search Committee

2014 Member, Basic Sciences Strategic Planning Committee in UW-SMPH

2013 - 2016 Member, Neuroscience Training Program Steering Committee

2013, 2015 Member, UW – Internal Review Committee - Brain Research Foundation

Grants

2012 – 2013 Member, UW - Faculty Consultative Committee on Financial Emergency

2010 – 2013 Member, UW-Biological Sciences Tenure Committee

2013 Member, Post-tenure review committee (Bill Chiu)

2013 Chair, Physiology Graduate Program Prelim Committee

2012 Member, Physiology Graduate Program Prelim Committee

2012 Member, Post-tenure review committees (June Dahl and Lea Ziskind

Conhaim)

2012 Member, Review Committee Endocrinology & Reproductive Physiology

Program

2011 - 2012 Member, Search Committee for Department of Biomolecular Chemistry

Chair

2011 – 2013 Member, Department of Neuroscience, Task Force Committee

2011 Member, Department of Neuroscience, Tenure Guideline Committee

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2009 – 2012 Member, Graduate Admissions Committee, Neuroscience Training

Program

2009 Member, Basic Science Department Restructuring in UW-SMPH Task

Force

2009 – 2010 Member, Faculty Search Committee, Department of Physiology

2009 – 2011 Member, Dept. of Physiology Awards Committee

2009 Member, C06 Construction Grant Leadership Group, co-wrote grant

proposal to NIH for building one floor of WIMRII for neuroscience and

regenerative medicine (grant did not get funded)

2008 Member, Search Committee for Department of Medicine Chair

2008 Member, Search Committee for Dept. Anesthesiology tenure track faculty

2006 – 2012 Chair, faculty mentoring committee for Dr. Baron Chanda, Physiology

Dept.

2006 – 2009 Member, University of Wisconsin - Medical Education and Research

Committee

2006 – 2007 Member, Search Committee for Chair of Anesthesiology Department

2005 - 2006 Acting Chair, Neuroscience Training Program

2005 Member, Campus Review Panel for the Searle Scholars Program

2004, 2005 Member, Faculty Search Committee, Department of Physiology

2004 – 2012 Member, Fellowship Committee, Molecular and Cellular Pharmacology

Training Program

2003 – 2006 Member, Carnegie Initiative on the Doctorate

2003 – 2016 Member, Jerzy Rose Neuroscience Award committee

2003 - 2004 Member, Strategic Planning Committee for the Medical School –

Research Subcommittee

2001 – 2004 Member, UW - Graduate School Research Committee. This committee

reviews and decides on the funding of research proposals from

investigators in the biological sciences and selects University

Distinguished Professorships (Romnes, Kellett Mid-Career, and WARF

Professorships for the Biological Sciences).

2000 – 2007 Member, faculty mentoring committee for Dr. Matt Jones, Dept. of

Physiology

2002 – 2010 Member, affiliate faculty appointment committee, Dept. of Physiology

2001 – 2004 Member, fall seminar series committee, Dept. of Physiology

2000 – 2006 Member, executive committee, Neuroscience Training Program

1999 – 2002 Chair, Graduate Admissions and Recruiting Committee, Neuroscience

Training Program

1996 – 2002 Member, Steering Committee, Molecular and Cellular Pharmacology

Training Program

1996 - 2001 Faculty Senator for Department of Physiology

1999 – 2001 Member, 1st year advisory committee, Neuroscience Training Program

1999 Member, Graduate Admissions Committee, Molecular and Cellular

Pharmacology Training Program

1998 Member, Faculty Search Committee, Department of Physiology

1997 - 1998 Member, Organizing Committee, UW/HHMI 1998 Summer Symposium

on Membrane Proteins

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1997 Member, Graduate Admissions Committee, Department of Physiology

1996 - 1997 Member, Graduate Admissions Committee, Neuroscience Training

Program

1996 – 1997 Co-chair, Graduate Admissions Committee, Molecular and Cellular

Pharmacology Training Program

1994 - pres Faculty Trainer: Biophysics Training Program, Cell & Molecular Biology

Training Program, Chemistry/Biology Interface Training Program,

MD/PhD Training Program, Molecular Biosciences Training Program,

Molecular and Cellular Pharmacology Training Program, Neuroscience

Training Program, Physiology Training Program

SERVICE – NATIONAL and INTERNATIONAL

Review Boards and Study Sections

1) NIH Study Section MDCN3/BSCT (Oct. 1999 – June 2004) full-time member

2) Canadian Institutes of Health Research grant reviewer (Nov. 2004)

3) NSF grant reviewer (May 2001)

4) NIH Study Section (special review committee) Dec 1999

5) NIH–NIGMS Special Emphasis Panel (1998) Member of site-visit and review of

program project grant on volatile and general anesthetics

6) NIH–NIAA Special Review Committee (1998) Member of site-visit and review of an

alcohol research center grant

7) NIH–NIGMS Special Emphasis Panel (1997) Member of site-visit and review of a

center grant on volatile and general anesthetics

8) NIH Study Section - Special Emphasis Panel (July 2007)

9) NIH Study Section - Special Emphasis Panel (ZRG1 MDCN-C (02) Feb. 2009) –

Chair

10) NIH Study Section – BPNS – June 2009 – adhoc member

11) Biotechnology and Biological Sciences Research Council (UK) – grant reviewer

9/2010

12) NIH Study Section – Chair - Special Emphasis Panel (ZRG1 MDCN-N (02) Oct.

2010

13) Wellcome Trust (UK) – grant reviewer 12/2011

14) NIH Study Section – Special Emphasis Panel (2012) review of a center grant on

volatile and general anesthetics

15) Wellcome Trust (UK) – grant reviewer 2/2012

16) Research Foundation – Flanders (FWO) – Belgian – grant reviewer 9/2012

17) Institut Pasteur – France – grant reviewer 11/2012

18) Biotechnology and Biological Sciences Research Council (BBSRC) – UK – grant

reviewer 1/2013

19) Austrian Science Fund – grant reviewer – 3/2013

20) Research Council - University of Leuven, Belgium – grant reviewer – 3/2013

21) NIH Study Section – Special Emphasis Panel (2013) reviewer for grants submitted in

response to Exceptional Unconventional Research Enabling Knowledge Acceleration

(EUREKA) for Neuroscience and Disorders of the Nervous System (R01)

announcement.

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Czajkowski CV

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22) Neurological Foundation of New Zealand - grant reviewer 11/2013

23) NIH Study Section - Reviewer- PPG on mechanisms of anesthesia 3/2014

24) MRC (UK) - grant reviewer 4/2014

25) NIH Study Section - Reviewer - Study section panel phone reviewer 6/2014

26) NIH Study Section - Reviewer - R13 Conference Review panel 2/2015

27) NIH Study Section - Reviewer - pre and postdoctoral NRSAs 11/2016

Editorships

2007 – 2013 Associate Editor – Journal of Neuroscience

2010 – pres Editorial Board – Biophysical Journal

2014 - pres Editorial Board - Journal of General Physiology

Consultant

1) Neurion Pharmaceutical, Pasedena, CA (August 2003 – 2006)

2) Sepracor (2006-2008)

3) Ironwood Pharmaceuticals (2013 – 2015)

Board Memberships:

1) Advisory Board Member - Biophysical Society - Institute of Physics Publishing

Manuscript Reviewer – Reviewer for the following journals: Nature, Nature

Neuroscience, Nature Communications, Nature Structural Biology, Neuron, Journal of

Neuroscience, Molecular Pharmacology, Journal of Biological Chemistry, Journal of

Neurochemistry, Biophysical Journal, Biochemistry, Journal of General Physiology,

PNAS, FASEB J, EMBO J, Journal of Physiology, Plos Biology, Plos One, British

Journal of Pharmacology, e-Life.