CVM faculty on Bacterial Infectious Diseases

Yinduo JiDepartment of Veterinary Biomedical

Sciences

Faculty Expertise• Epidemiology• Bacterial pathogenesis• Mechanism of antibiotic resistance• Microbiome/metagenomics • Vaccine development• Novel antibacterial discovery• Diagnosis

Bacterial pathogenesis• Gram-negative pathogens:– Escherichia coli, Salmonella enterica, Lawsonia

intracellularis, Haemophilus parasuis

• Gram-positive pathogens:– Staphylococcus aureus, including MRSA,

Streptococcus suits, Mycobacterium avium subsp. paratuberculosis (MAP) and M. bovis

• Microbe-host interaction• Microbe-microbe interactions

Approaches

• Genetics• Genomics• Metagenomics• Proteomics• System biology• Cell culture• Animal Models

Current projects• Identification and validation of novel targets in vitro

and in vivo• Development of high throughput screening of

antibacterial inhibitor• Whole-cell screening of novel antibacterial small

molecules• Identification of mode of action for novel antibacterial

agents• Investigation of molecular mechanisms of antibiotic

resistance• Microbial population shifts in response to antibacterials