CHARITÉ - UNIVERSITÄTSMEDIZIN BERLIN Charitéplatz 1 ⏐ 10117 Berlin ⏐ Telefon +49 30 28460-760 ⏐ www.charite.de

CV Univ.-Prof. Dr. rer. nat. Max Löhning Pitzer Professor of Osteoarthritis Research & Immunology Head of Pitzer Laboratory of Osteoarthritis Research Charité – Universitätsmedizin Berlin Department of Rheumatology and Clinical Immunology German Rheumatism Research Center Berlin (DRFZ) Charitéplatz 1 | D-10117 Berlin | Germany Tel./Fax: +49 (0)30 / 28460-760 / -773 E-mail: max.loehning@charite.de / loehning@drfz.de

Scientific education and positions 2015–today University Professor (W3) of Osteoarthritis Research and Immunology at Charité and

Head of Pitzer Laboratory of Osteoarthritis Research at DRFZ, Berlin 2013 Primo loco and offer of full professorship (W3) and Head of Department of Immunology

at Universitätsmedizin Greifswald; 2014 declined 2012–2014 University Professor of Experimental Immunology at Charité, Berlin 2006–2011 Lichtenberg Professor at Charité, funded by Volkswagen Foundation 2003–2006 Postdoc fellow of Ernst Schering Foundation with R.M. Zinkernagel & H. Hengartner at

the Inst. of Experimental Immunology, ETH and University Hospital Zurich, Switzerland 2000–2002 Postdoc fellow with A. Radbruch at the German Rheumatism Research Center, Berlin 1999–2000 Research fellow with W.E. Paul at the NIH, NIAID, Bethesda, MD, and with K.M. Murphy

at the Washington University-School of Medicine, St. Louis, MO, USA 1996–2000 PhD thesis at the Inst. of Genetics, University of Cologne; 2000 Dr. rer. nat. 1990–1996 Biology studies at the University of Mainz; 1996 Diploma in biology

Scientific self-administration and scientific interactions 2014–today Founder spokesperson of the board of BIH Young Science at Berlin Institute of Health 2013–today Head of the integrated graduate program of SFB 650 at Charité, Berlin 2012–today Vice Director of Research Center ImmunoSciences (RCIS) at Charité; executive board

member of RCIS since 2006 2009–today Executive board member of ZIBI Graduate School (Interdisciplinary Center for Infection

Biology and Immunity) at Humboldt-Universität zu Berlin 2009–today Executive board member and scientific secretary (2009–2011) of SFB 650, Charité 2008–2011 Head of the section Immunology and Infectious Diseases of the Life Science School of

the Studienstiftung des deutschen Volkes 2007–today Executive board member of the International Max Planck Research School for Infectious

Diseases and Immunology (IMPRS-IDI), Berlin

Honors, awards, fellowships 2015–today Pitzer Professorship funded by Willy Robert Pitzer Foundation 2013–today Member of Berlin-Brandenburg Academy of Sciences (BBAW); Vice Secretary of the

Class Biosciences & Medicine since 2014 2010 Georges-Köhler-Prize of the German Society for Immunology 2006–2014 Lichtenberg Professorship funded by Volkswagen Foundation 2004–2009 Member of Die Junge Akademie (The German Young Academy) at the BBAW and the

German National Academy of Sciences Leopoldina 2004 Robert-Koch-Postdoctoral-Prize of Robert Koch Foundation 2003–2004 Postdoctoral fellowship of Ernst Schering Foundation 2000 Avrion-Mitchison-Prize for Rheumatology of Ernst Schering Foundation 2000 Otto-Westphal-PhD-Prize of the German Society for Immunology 1993–2000 Diploma and PhD fellowships of the Studienstiftung des deutschen Volkes

Max Löhning - CV, Dec. 2015

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20 most recent original publications 1. Bhattacharya, A., A.N. Hegazy, N. Deigendesch, L. Kosack, J. Cupovic, R.K. Kandasamy, A. Hildebrandt, D. Merkler, A.A.

Kühl, B. Vilagos, C. Schliehe, I. Panse, K. Khamina, H. Baazim, I. Arnold, L. Flatz, H.C. Xu, P.A. Lang, A. Aderem, A. Takaoka, G. Superti-Furga, J. Colinge, B. Ludewig, M. Löhning* and A. Bergthaler*. 2015. Superoxide dismutase 1 protects hepatocytes from type I interferon-driven oxidative damage. Immunity 43, 974-986 )*Co-senior authors.

2. Honke, N., N. Shaabani, K. Merches, A. Gassa, A. Kraft, K. Ehrhardt, D. Häussinger, M. Löhning, U. Dittmer, H. Hengel, M. Recher, P.A. Lang, and K.S. Lang. 2015. Immunoactivation induced by chronic viral infection inhibits viral replication and drives immunosuppression through sustained IFN-I responses. Eur. J. Immunol. doi: 10.1002/eji.201545765.

3. Baumann, C., W.V. Bonilla, A. Fröhlich, C. Helmstetter, M. Peine, A.N. Hegazy, D.D. Pinschewer, and M. Löhning. 2015. T-bet– and STAT4–dependent IL-33 receptor expression directly promotes antiviral Th1 cell responses. Proc. Natl. Acad. Sci. USA 112, 4056-4061.

4. Xu, H.C., J. Huang, V. Khairnar, V. Duhan, A.A. Pandyra, M. Grusdat, P. Shinde, D.R. McIlwain, S.K. Maney, J. Gommerman, M. Löhning, P.S. Ohashi, T.W. Mak, K. Pieper, H. Sic, M. Speletas, H. Eibel, C.F. Ware, A. Tumanov, A. Kruglov, S. Nedospasov, D. Häusinger, M. Recher, K.S. Lang, and P.A. Lang. 2015. Deficiency of the B cell-activating factor receptor results in limited CD169+ macrophage function during viral infection. J. Virol. 89, 4748-4759.

5. Helmstetter, C., M. Flossdorf, M. Peine, A. Kupz, J. Zhu, A.N. Hegazy, M.A. Duque-Correa, Q. Zhang, Y. Vainshtein, A. Radbruch, S.H. Kaufmann, W.E. Paul, T. Höfer, and M. Löhning. 2015. Individual T helper cells have a quantitative cytokine memory. Immunity 42, 108-122.

6. Haftmann, C., A.-B. Stittrich, J. Zimmermann, Z. Fang, K. Hradilkova, M. Bardua, K. Westendorf, G.A. Heinz, R. Riedel, J. Siede, E.E. Weinberger, D. Zimmel, U. Lauer, T. Häupl, J. Sieper, M. Backhaus, C. Neumann, U. Hoffmann, M. Porstner, W. Chen, J.R. Grün, R. Baumgrass, M. Matz, M. Löhning, A. Scheffold, J. Wittmann, H.-D. Chang, N. Rajewsky, H.-M. Jäck, A. Radbruch, and M.-F. Mashreghi. 2015. miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim. Eur. J. Immunol. 45, 1192-1205.

7. Schiering, C., T. Krausgruber, A. Chomka, A. Fröhlich, K. Adelmann, E.A. Wohlfert, A.N. Hegazy, O. Harrison, T. Griseri, J. Bollrath, M. Löhning, Y. Belkaid, P.G. Fallon, and F. Powrie. 2014. The alarmin interleukin-33 promotes regulatory T cell function in the intestine. Nature 513, 564-568.

8. Xu, H.C., M. Grusdat, A.A. Pandyra, R. Polz, J. Huang, P. Sharma, R. Deenen, K. Köhrer, R. Rhabar, A. Diefenbach, K. Gibbert, M. Löhning, L. Höcker, Z. Waibler, D. Häusinger, T.W. Mak, P.S. Ohashi, K.S. Lang, and P.A. Lang. 2014. Type I interferon protects anti-viral CD8+ T cells from NK cell cytotoxicity. Immunity 40, 949-960.

9. Honke, N., N. Shaabani, D.-E. Zhang, G. Iliakis, H.C. Xu, D. Häussinger, M. Recher, M. Löhning, P.A. Lang, and K.S. Lang. 2013. Usp18 driven enforced viral replication in dendritic cells contributes to break of immunological tolerance in autoimmune diabetes. PLoS Pathog. 9, e1003650.

10. Peine, M., S. Rausch, C. Helmstetter, A. Fröhlich, A.N. Hegazy, A.A. Kühl, C.G. Grevelding, T. Höfer, S. Hartmann, and M. Löhning. 2013. Stable T-bet+GATA-3+ Th1/Th2 hybrid cells arise in vivo, can develop directly from naive precursors, and limit immunopathologic inflammation. PLoS Biol. 11, e1001633.

11. Hanazawa, A., K. Hayashizaki, K Shinoda, H. Yagita, K. Okumura, M. Löhning, T. Hara, S. Tani-Ichi, K. Ikuta, B. Eckes, A. Radbruch, K. Tokoyoda, and T. Nakayama. 2013. CD49b-dependent establishment of T helper cell memory. Immunol. Cell Biol. 91, 524-531.

12. Raifer, H., A.J. Mahiny, N. Bollig, F. Petermann, A. Hellhund, K. Kellner, A. Guralnik, K. Reinhard, E. Bothur, M. Huber, S. Bauer, M. Löhning, E.A. Kiss, S.C. Ganal, A. Diefenbach, T. Korn, and M. Lohoff. 2012. Unlike αβ T cells, γδ T cells, LTi cells and NKT cells do not require IRF4 for the production of IL-17A and IL-22. Eur. J. Immunol. 42, 3189-3201.

13. Fangradt, M., M. Hahne, T. Gaber, C. Strehl, R. Rauch, P. Hoff, M. Löhning, G.-R. Burmester, and F. Buttgereit. 2012. Human monocytes and macrophages differ in their mechanisms of adaptation to hypoxia. Arthritis Res. Ther. 14, R181.

14. Oefner, C.M., A. Winkler, C. Hess, A.K. Lorenz, V. Holecska, M. Huxdorf, T. Schommartz, D. Petzold, J. Bitterling, A.-L. Schoen, A.D. Stoehr, D.V. Van, Y. Darcan, V. Blanchard, I. Schmudde, Y. Laumonnier, H.A. Ströver, A.N. Hegazy, S. Eiglmeier, C.T. Schoen, M.M.M. Mertes, C. Loddenkemper, M. Löhning, P. König, U. Jappe, A. Petersen, E. Luger, M. Collin, J. Köhl, A. Hutloff, E. Hamelmann, M. Berger, H. Wardemann, and M. Ehlers. 2012. Tolerance induction with T cell-dependent protein antigens induces regulatory sialylated IgGs. J. Allergy Clin. Immunol. 129, 1647-1655.

15. Bonilla, W.V., A. Fröhlich, K. Senn, S. Kallert, M. Fernandez, S. Johnson, M. Kreutzfeldt, A.N. Hegazy, C. Schrick, P.G. Fallon, R. Klemenz, S. Nakae, H. Adler, D. Merkler, M. Löhning* and D.D. Pinschewer*. 2012. The alarmin interleukin-33 drives protective antiviral CD8+ T cell responses. Science 335, 984-989 )*Co-senior authors.

16. Honke, N., N. Shaabani, G. Cadeddu, U.R. Sorg, D.E. Zhang, M. Trilling, K. Klingel, M. Sauter, R. Kandolf, N. Gailus, N. van Rooijen, C. Burkart, S.E. Baldus, M. Grusdat, M. Löhning, H. Hengel, K. Pfeffer, M. Tanaka, D. Häussinger, M. Recher, P.A. Lang, and K.S. Lang. 2011. Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus. Nature Immunol. 13, 51-57.

17. Chu, V.T., A. Fröhlich, G. Steinhauser, T. Scheel, T. Roch, S. Fillatreau, J.J. Lee, M. Löhning, and C. Berek. 2011. Eosinophils are required for the maintenance of plasma cells in the bone marrow. Nature Immunol. 12, 151-159.

18. Stittrich, A.-B., C. Haftmann, E. Sgouroudis, A.A. Kühl, A.N. Hegazy, I. Panse, R. Riedel, M. Flossdorf, J. Dong, F. Fuhrmann, G.A. Heinz, Z. Fang, N. Li, U. Bissels, F. Hatam, A. Jahn, B. Hammoud, M. Matz, F.-M. Schulze, R. Baumgrass, A. Bosio, H.-J. Mollenkopf, J. Grün, A. Thiel, W. Chen, T. Höfer, C. Loddenkemper, M. Löhning, H.-D. Chang, N. Rajewsky, A. Radbruch, and M.-F. Mashreghi. 2010. The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes. Nature Immunol. 11, 1057-1062.

19. Flatz, L., A.N. Hegazy, A. Bergthaler, A. Verschoor, C. Claus, M. Fernandez, L. Gattinoni, S. Johnson, F. Kreppel, S. Kochanek, M. van den Broek, A. Radbruch, F. Lévy, P.-H. Lambert, C.-A. Siegrist, N.P. Restifo, M. Löhning, A. Ochsenbein, G.J. Nabel, and D.D. Pinschewer. 2010. Development of replication-defective lymphocytic choriomeningitis virus vectors for induction of potent CD8+ T cell immunity. Nature Med. 16, 339-345.

20. Hegazy, A.N., M. Peine, C. Helmstetter, I. Panse, A. Fröhlich, A. Bergthaler, L. Flatz, D.D. Pinschewer, A. Radbruch, and M. Löhning. 2010. Interferons direct Th2 cell reprogramming to generate a stable GATA-3+T-bet+ cell subset with combined Th2 and Th1 cell functions. Immunity 32, 116-128.