c.v george dedoussis short 20183 supervisor!of!the!following!phd!thesis! 1)...
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GEORGE V.Z DEDOUSSIS, PHD
DATE AND PLACE OF BIRTH: 25TH OF MAY 1966 IN ATHENS
PROFESSOR OF HUMAN MOLECULAR GENETICS
NATIONALITY: GREEK
DEPARTMENT OF NUTRITION AND DIETETICS, HAROKOPIO UNIVERSITY, 70 EL. VENIZELOU
STR, 17671 KALLITHEA –ATHENS, TEL: 0030-‐210-‐9549304, CELL: 0030-‐6973536730, EMAIL: [email protected]
Diplomas and Awards
1988 Bachelor of Biology, University of Patras
1989 Erasmus fellowship for post-‐graduate studies in Compiegne, France.
1990 D.E.A of Biotechnology, Microbiology et Bioconversion, University of Compiegne, France. Title of
research project: “Production of human monoclonal antibodies against tumor antigens in breast
cancer”, Compiegne, France
1990-‐1994 Participation in the EEC program “Production of Monoclonal Antibodies against cancer” Saint Savas
Anticancer Hospital of Athens
1995 PhD Thesis. “Phenotypic and functional characterization of tumor infiltrating lymphocytes in breast
cancer”. Medical School of Athens.
1996-‐1998 Post-‐Doctoral research in the laboratory of Molecular Biology in the Center of Thalassaemia in
Athens. Participation in the EEC program EPET I “Development of new biotechnological approaches
for the diagnosis and therapy of genetic disorders.
2004
2010-‐today
2009-‐today
2000-‐today
2018
Fulbright Fellow for three months at Harvard Medical School, Department of Genetics, Boston
Guest Editor in Genetics: Current Nutrition Reports
Grant reviewer for the Greek General Secretary of Research and Technology GREECE, Institute
National de la santé et de la recherché medicale, 101. Rue de Tolbiac, 75654 Paris Cedex 13,
FRANCE, Romanian National Council for Scientific Research, Schitu Magureanu Blvd, 3rd floor, 5th
sector, 050025 Bucharest, Romania.
Grants awarded from National funding, private sector and European Union, in total >4.000.000
Euros.
Among the higly cited scientists for the last decade
Professional situation
1990-‐1994 Participation in the EEC program “Production of Monoclonal Antibodies against cancer” Saint Savas
Anticancer Hospital of Athens
1991=2000 Lecturer at the Department of Psychology, University of Rouen, and the Department of Sociology,
University of Strasburg, France in collaboration with the Francophone college (CFES)
2000-‐2004 Lecturer of Molecular Biology
2004-‐2008 Assistant Professor of Human Cellular and Molecular Biology
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2009-‐2013 Associate Professor of Human Cellular and Molecular Biology
2013-‐today Full Professor
Administration assignements
Institutional coordinator of the Erasmus program (2011-‐2018)
Board Member of the University Council (2012-‐2016)
Member of the National Research and Innovation Council (2016-‐2020)
Director of the Laboratory of Biology/Biochemistry/Microbiology/Physiology (2017-‐2020)
Invited speaker in international meetings
1. 8th International Seminar of the Greek Institute of Osteoporosis, Athens, November 2003. Speaker in
roundtable on "The role of genetics in the pathogenesis of osteoporosis."
2. Biologie Prospective -‐ Santorini Conference 2004 From Human Genetic Variations to Prediction of Risks
and Responses to the Environment.
3. ESPT (European Society of Pharmacogenetics and Theranostics) Summer School, Lyublyana 2012. Two
lectures: Introduction to Human Genetics, Nutrigenetics/Nutrigenomics.
4. 6th Santorini Conference Biology Prospective “Systems Biology and Personalised Health Science and
Translation” Title of Lecture: Gene Environment Interactions, Santorini, 30/09-‐02/10/2012.
5. 3rd congress of the European Society of Preventive Medicine (EUSPM), Riolo Terme, Italy, 9-‐10 March,
2013. Title of Lecture: Genetic predisposition of childhood obesity. The impact of nutrition.
6. EASD NAFLD Study Group Meeting NewCastle, 11th-‐12th May 2015. The Hellenique NAFLD study.
Genetics and Lifestyle determinants. Nutritional intervention with Corinthian raisins.
7. 7th Santorini Conference Biology Prospective “Systems Biology and Personalised Health Science and
Translation” Title of Lecture: Non-‐alcoholic fatty liver disease. Genetic etiology and nutritional
intervention, Santorini, 25-‐27/9/2014.
8. 8th Santorini Conference: Systems Medicine and Personalized Health and Therapy, Title of Lecture:
Nutritional interventions in Non-‐alcoholic fatty liver disease. The MAST4HEALTH program. Santorini,
Greece, 3-‐5 October 2016.
Visiting Professor abroad
[1] Visiting Professor, (2004, 2007, 2009, 2010, 2018), at INSERM U525 Equipe 4, Faculté de Pharmacie -‐
UHP Nancy 1 (Director: Professor Gérard SIEST), 30 rue Lionnois -‐ 54000 NANCY – France.
[2] Visiting Professor at the University of Tartu, Estonia, under the auspices of bilateral collaborations
Greece-‐Estonia, 6/2006.
Academic duties
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Supervisor of the following PhD thesis
1) Mutation analysis in Familial Hypercholesterolemia patients of Greek and German origin. (Status: completed).
2) Mutation analysis of SLC3A1 and SLC7A9 genes in Greek patients with cystinuria. (Status: completed). 3) Interactions of genes, nutrition and lifestyle determinants in ageing people. (Status: completed). 4) Interactions of genetic and nutrition determinants in childhood obesity. (Status: completed). 5) Dietary patterns and genetic predisposition on phenotypes associated with cardiovascular disease.
(Status: completed). 6) Cardiometabolic indices in isolated cohorts: Genetic predisposition and environmental modifiers.
(Status: completed). 7) Genomics in extreme obesity. (Status: in progress, expected to defend soon). 8) Interactions of genetic variants with lifestyle determinants in bone metabolism indices. (Status:
expected to defend soon). 9) Non alcoholic fatty liver disease. Genetic aetiology and interactions with dietary factots. (Status:
completed). 10) Functional Biology in cardiovascular disease. (Status: in progress). 11) Design of prognostic computational tools in Non-‐Alcoholic Fatty Liver Disease. (Status: in progress).
Research Grants awarded (>4,000,000 Euros)
Project acronym Title Funding Agency Duration (years)
Budget (Euros)
PAVET 2000 (coordinator)
Methods for the analysis recording and saving of genetic data in Familial Hypercholesterolemia (FH)
Secretary of research and innovation of
Greek ministry (GSRT)
2 255.320
IKYDA 2001 (coordinator)
Mutation analysis of LDL-‐R gene in Greek and German patients with FH.
IKY 2 15.000
Private (coordinator)
Association of CTR genotype with responsiveness to therapy with calcitonin in meta-‐menopausal females with osteoporosis.
Novartis 1 5.000
PENED 2003 (coordinator)
Study of polymorphisms in endothelium inflammation. Dietary determinatns as modifiers in gene expression in cardiovascular disease.
GSRT 3 67.500
ZINCAGE (partner)
Nutritional zinc, oxidative stress and immunosenescence: biochemical, genetic and lifestyle implications for healthy ageing
FP6-‐FOOD European Community
3 115.000
EUGINDAT (partner)
European Genomics Initiative on Disorders of Plasma membrane Amino acid Transporters
FP6-‐2002-‐LIFESCIHEALTH
3 25.000
GENDAI (coordinator)
Gene nutrient interactions in childhood obesity
Coca Cola 2 100.000
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WilsonIndia (partner)
Novel opportunities for diagnosis and therapy of Wilson’s disease in India
FP7-‐PEOPLE-‐2009-‐IRSES. Marie Curie
3 7.500
Androgenetic Alopecia (coordinator)
Genetic predisposition of androgenetic alopecia
DHI Global Medical Group
1 11.800
HELIC (co-‐coordinator)
Study of cardiometabolic indices in Hellenic Isolated Cohorts
Wellcome Trust Sanger Institute
2 147.000
HRAKLEITOS ΙΙ (coordinator)
Gene-‐dietary patterns interactions in childhood obesity
Ministry of Education and religion affairs
3 38.750
Cooperation 2011 (partner)
Obesity and metabolic syndrom: Nutritional intervention with Corinthian raisins in NAFLD/ NASH patients. Exploration of molecular mechanisms.
GSRT 3 245.000
Erasmus 2011-‐16 (coordinator)
Placements of Harokopio University students and staff members
ΙΚΥ 4 350.000
THALIS (coordinator)
Genomic study in morbid obesity. Genetic risk varinats, the role of nutrition and the lifgestyle.
Ministry of Education and religion affairs
3 585.000
Marie-‐Curie RISE (coordinator)
Mastiha treatment for healthy obese with NAFLD diagnosis (MAST4HEALTH).
EU 4 2.124.000
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Publications (15 out of 275)
1. Giri A, Hellwege JN, Keaton JM, ...Dedoussis G,... Edwards TL. Trans-‐ethnic association study of blood pressure determinants in over 750,000 individuals. Nat Genet. 2019 Jan;51(1):51-‐62. doi: 10.1038/s41588-‐018-‐0303-‐9.
2. Gilly A, Southam L, Suveges D, Kuchenbaecker K, Moore R, Melloni GEM, Hatzikotoulas K, Farmaki AE, Ritchie G, Schwartzentruber J, Danecek P, Kilian B, Pollard MO, Ge X, Tsafantakis E, Dedoussis G, Zeggini E. Very low depth whole genome sequencing in complex trait association studies. Bioinformatics. 2018 Dec 21. doi: 10.1093/bioinformatics/bty1032.
ACADEMIC SCORING Citations h-factor Total impact factor Mean impact factor Publications
>45000 70 >6000 21 275
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3. Hackinger S, Prins B, Mamakou V, Zengini E, Marouli E, Brčić L, Serafetinidis I, Lamnissou K, Kontaxakis V, Dedoussis G, Gonidakis F, Thanopoulou A, Tentolouris N, Tsezou A, Zeggini E. Evidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia. Transl Psychiatry. 2018 Nov 23;8(1):252. doi: 10.1038/s41398-‐018-‐0304-‐6.
4. Gilly A, Suveges D, Kuchenbaecker K, Pollard M, Southam L, Hatzikotoulas K, Farmaki AE, Bjornland T, Waples R, Appel EVR, Casalone E, Melloni G, Kilian B, Rayner NW, Ntalla I, Kundu K, Walter K, Danesh J, Butterworth A, Barroso I, Tsafantakis E, Dedoussis G, Moltke I, Zeggini E. Cohort-‐wide deep whole genome sequencing and the allelic architecture of complex traits. Nat Commun. 2018 Nov 7;9(1):4674. doi: 10.1038/s41467-‐018-‐07070-‐8.
5. Mahajan A, Taliun D, Thurner M, Dedoussis G,..McCarthy MI. Fine-‐mapping type 2 diabetes loci to single-‐variant resolution using high-‐density imputation and islet-‐specific epigenome maps. Nat Genet. 2018 Nov;50(11):1505-‐1513. doi: 10.1038/s41588-‐018-‐0241-‐6.
6. Turcot V, Lu Y, Highland HM,…Dedoussis G…Loos RJF.Protein-‐altering variants associated with body
mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet. 2018 Jan;50(1):26-‐41. doi: 10.1038/s41588-‐017-‐0011-‐x.
7. Kraja A, Cook JP, Warren HR,...Dedoussis G,…. Howson J. New Blood Pressure Associated Loci
Identified in Meta-‐Analysis of 475.000 individuals. Circ Cardiovasc Genet. 2017 Oct. doi: 10.1161/CIRCGENETICS.117.001.778.
8. Mozaffarian D, Dashti HS, Wojczynski MK,… Dedoussis G, Chasman DI, Raitakari O, Tanaka T.
Genome-‐wide association meta-‐analysis of fish and EPA+DHA consumption in 17 US and European cohorts. PLoS One. 2017 Dec 13;12(12):e0186456. doi: 10.1371/journal.pone.0186456.
9. Marouli E, Kanoni S, Mamakou V, Hackinger S, Southam L, Prins B, Rentari A, Dimitriou M, Zengini E,
Gonidakis F, Kolovou G, Kontaxakis V, Rallidis L, Tentolouris N, Thanopoulou A, Lamnissou K, Dedoussis G, Zeggini E, Deloukas P. Evaluating the glucose raising effect of established loci via a genetic risk score. PLoS One. 2017 Nov 10;12(11):e0186669. doi: 10.1371/journal.pone.0186669.
10. Stathopoulou M, Xie T, Ruggiero D,…,Dedoussis G,..,Visvikis-‐Siest S. -‐ The VEGF ConsortiumA
transnational collaborative network dedicated to the study and applications of the Vascular Endothelial Growth Factor–A in medical practice: The VEGF Consortium". Clin Chem Lab Med. 2017 Oct 31. pii: /j/cclm.ahead-‐of-‐print/cclm-‐2017-‐0838/cclm-‐2017-‐0838.xml. doi: 10.1515/cclm-‐2017-‐0838.
11. Liu DJ, Peloso GM, Yu H…Dedoussis G,…,Kathiresan S. Exome-‐wide association study of plasma lipids
in >300,000 individuals. Nat Genet. 2017 Dec;49(12):1758-‐1766. doi: 10.1038/ng.3977.
12. Tachmazidou I, Süveges D, Min JL, …Dedoussis G,…,Zeggini E. Whole-‐Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits. Am J Hum Genet. 2017 Jun 1;100(6):865-‐884. doi: 10.1016/j.ajhg.2017.04.014.
13. Nelson CP, Goel A, Butterworth AS,…Dedoussis G,…,Deloukas P. Association analyses based on false
discovery rate implicate new loci for coronary artery disease. Nat Genet. 2017 Sep;49(9):1385-‐1391. doi: 10.1038/ng.3913.
14. Kaliora AC, Kalafati IP, Gioxari A, Diolintzi A, Kokkinos A, Dedoussis GV. A modified response of
NAFLD patients with non-‐significant fibrosis in nutritional counseling according to GCKR rs1260326. Eur J Nutr. 2017 Jul 10. doi: 10.1007/s00394-‐017-‐1499-‐7.
15. Xue Y, Mezzavilla M, Haber M, McCarthy S, Chen Y, Narasimhan V, Gilly A, Ayub Q, Colonna V,
Southam L, Finan C, Massaia A, Chheda H, Palta P, Ritchie G, Asimit J, Dedoussis G, Gasparini P, Palotie A, Ripatti S, Soranzo N, Toniolo D, Wilson JF, Durbin R, Tyler-‐Smith C, Zeggini E. Enrichment of low-‐frequency functional variants revealed by whole-‐genome sequencing of multiple isolated European populations. Nat Commun. 2017 Jun 23;8:15927. doi: 10.1038/ncomms15927.