Senior Post-doctoral Fellow

Ph.D. of Molecular Cell Biology

04/2017- 02/2020

Achievements

Expertise

Professional Experience

Education

CRISPR-Cas9 Cancer Genetic Screening Regulatory DNA NGS

korkmazgozde@gmail.com

The Netherlands Cancer Institute - Reuven Agami

Biological Sciences and Bioengineering program, Sabanci University

Istanbul, TURKEY

Amsterdam, The Netherlands

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Istanbul, TURKEY

+31 6 52 72 69 57+90 538 361 21 51

in https://www.linkedin.com/in/gözde-korkmaz-445b1647/

https://scholar.google.com/citations?user=QYPsL78AAAAJ&hl=tr

Post-doctoral Fellow

10/2012- 04/2017

2007-2012

The Netherlands Cancer Institute - Reuven Agami

Guidance: 1 PhD student, 5 Master studentsTalks: NKI CRISPR meetings (2014&2017), NKI Staff meeting (2016), Keystone Conference (2016)

Gözde KorkmazAssistant Professor

- Specialized on the application and development of unbiased functional genetic screening approaches (RNAi, CRISPR-Cas9, etc.) to define the importance of non-coding part of the genome by using different biological systems.- Performed the first CRISPR-based functional genomic screen that targets enhancer regions.- Highly ambitious, result-driven professional with proven track record.- Focused on the soft skills to advance leadership and communication.

Certificates: Influence and Impact, Collaboration and Ownership, Strategic Thinking and Entrepreneurship, Communication and Cooperation, Creating Your Future

GPA: 3.85 / 4.00

Autophagy

PhD Thesis: Regulation of autophagy through miRNAs.Under the supervision of Devrim Gözüaçık, PhD

M.Sc. of Plant ScienceBiological Sciences and Bioengineering program, Sabanci University

Istanbul, TURKEY

2005-2007GPA: 3.78 / 4.00 Molecular analysis of historical variety candidates discovered in Urla.

Under the supervision of Selim Çetiner, PhD

gkorkmaz@ku.edu.tr

Reviewing manuscripts for Autophagy journal

Asistant ProfessorSchool of Medicine, Koç University, Istanbul Turkey02/2020 - ...

İstanbul, Turkey

Amsterdam, The Netherlands

ranked 8th out of 22

Bachelor of ScienceMajor, Molecular Biology and Genetics Program, Istanbul Technical University

Istanbul, TURKEY

2000-2005GPA: 3.18 / 4.00 Graduation Project: Dye decolourisation using white rotter

Trametes versicolor 52J and possible role of redox mediatorsUnder the supervision of Hakan Bermek, PhD

Patent

Publications (* shared first authorship, # corresponding authors)

Gozuacık D and Korkmaz G (PhD Student). Use of miRNAs for the diagnosis, propylaxis, treatment and follow- up of diseases involving macroautophagy abnormalities. World Intellectual Property Organization (WIPO)-Patent Cooperation Treaty (PCT). Patent Number: PCT/TR2010/000192. April 05, 2012-2015. Status: Pending (Country evaluation phase in the US, Canada, Asia). Gozuacık D and Korkmaz G (PhD Student). Use of miRNAs for the diagnosis, propylaxis, treatment and follow- up of diseases involving macroautophagy abnormalities. European Patent Office Patent Number: EP10777121.4. April 05, 2012-2015. Status: Approved (European Union).

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1: Korkmaz G#, Manber Z, Lopes R, Prekovic S, Schuurman K, Kim Y, Teunissen H, Flach K, de Wit E, Galli GG, Zwart W, Elkon R#, Agami R#. A CRISPR-Cas9 screen identifies essential CTCF anchor sites for the mitogenic function of ER-alpha in breast cancer. Nucleic Acids Research, Volume 47, Issue 18, 10 October 2019, Pages 9557–9572, https://doi.org/10.1093/nar/gkz675

2: Lopes R*, Korkmaz G#*, Aristin SA, van Vliet R, Nagel R, Custers L, Kim Y, van Breugel PC, Zwart W, Moumbeini B, Manber Z, Elkon R, Agami R#.CUEDC1 is a primary target of ERα essential for the growth of breast cancer cells. Cancer Letters. 2018 August, 23;436:87-95. doi:10.1016/j.canlet.2018.08.018.

3: Li L, van Breugel PC, Loayza-Puch F, Ugalde AP, Korkmaz G, Messika-Gold N, Han R, Lopes R, Barbera EP, Teunissen H, de Wit E, Soares RJ, Nielsen BS, HolmstrømK, Martínez-Herrera DJ, Huarte M, Louloupi A, Drost J, Elkon R, Agami R. LncRNA-OIS1 regulates DPP4 activation to modulate senescence induced by RAS.Nucleic Acids Res. 2018 Feb 22. doi: 10.1093/nar/gky087.

4: Lopes R*, Agami R#, Korkmaz G#*. GRO-seq, A Tool for Identification of Transcripts Regulating Gene Expression. Methods Mol Biol. 2017;1543:45-55. doi:10.1007/978-1-4939-6716-2_3. PubMed PMID: 28349421.

5: Lopes R*, Korkmaz G#*, Agami R#. Applying CRISPR-Cas9 tools to identify and characterize transcriptional enhancers. Nat Rev Mol Cell Biol. 2016 Sep;17(9):597-604. doi: 10.1038/nrm.2016.79.

6: Korkmaz G*, Lopes R*, Ugalde AP, Nevedomskaya E, Han R, Myacheva K, Zwart W, Elkon R, Agami R. Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9. Nat Biotechnol. 2016 Feb;34(2):192-8. doi:10.1038/nbt.3450.

7: Elkon R, Loayza-Puch F, Korkmaz G, Lopes R, van Breugel PC, Bleijerveld OB, Altelaar AF, Wolf E, Lorenzin F, Eilers M, Agami R. Myc coordinates transcription and translation to enhance transformation and suppress invasive-ness. EMBO Rep. 2015 Dec;16(12):1723-36. doi: 10.15252/embr.201540717.

8: Léveillé N, Melo CA, Rooijers K, Díaz-Lagares A, Melo SA, Korkmaz G, Lopes R, Akbari Moqadam F, Maia AR, Wijchers PJ, Geeven G, den Boer ML, Kalluri R, de Laat W, Esteller M, Agami R. Genome-wide profiling of p53-regu-lated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA. Nat Commun. 2015 Mar 27;6:6520. doi: 10.1038/ncomms7520.

9: Korkmaz G*, Tekirdag KA*, Ozturk DG, Kosar A, Sezerman OU, Gozuacik D. MIR376A is a regulator of starvation induced autophagy. PLoS One. 2013 Dec 16;8(12):e82556. doi: 10.1371/journal.pone.0082556. eCollection 2013. Erratum in: PLoS One. 2014;9(7):e103385.

10: Tekirdag KA*, Korkmaz G*, Ozturk DG, Agami R, Gozuacik D. MIR181A regulates starvation- and rapamycin-in-duced autophagy through targeting of ATG5. Autophagy. 2013 Mar;9(3):374-85. doi: 10.4161/auto.23117.

11: Kuzuoglu-Ozturk D, Cebeci Yalcinkaya O, Akpinar BA, Mitou G, Korkmaz G, Gozuacik D, Budak H. Autophagy related gene, TdAtg8, in wild emmer wheat plays a role in drought and osmotic stress response. Planta. 2012 Oct;236(4):1081-92. Epub 2012 May 9. PubMed PMID: 22569921.

12: Korkmaz G, le Sage C, Tekirdag KA, Agami R, Gozuacik D. miR-376b controls. starvation and mTOR inhibition related autophagy by targeting ATG4C and BECN1. Autophagy. 2012 Feb 1;8(2):165-76. doi: 10.4161/auto.8.2.18351.

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Scholarships & Awards2020 - 2023: TUBITAK - 2232 International fellowship for outstanding researchers

PhD:2007-2010 – TUBITAK Project Scholarship and Tuition Scholarship from Sabanci University.2010-Summer TAGEV Scholarship for attending a congress2010-2012 - Yousef Jameel Scholarship(Covers the tuition fee, technology fee, housing and monthly stipend.)2011-Fall Scholarship for attending a congress (from Sabanci University)PhD student who published a paper applied to this scholarship in order to present his/her data in congress.

Oral Presentations“CRISPR-Cas9 based functional genetic screens for enhancer elements”, Seminar, Molecular Biology and Genetic Department – Bosphorus University, 06 May 2016.“Noncoding DNA is in charge: Regulation of autophagy and cell proliferation”, 2nd Autophagy Practical Course and Symposium in Istanbul, Karakoy Minerva Han, Istanbul, Turkey, 2-3 May 2016.Selected for short talk: “Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9”, Noncoding RNAs in Health and Disease (Keystone Symposia), Santa Fe, New Mexico, USA, 21-21 February 2016.

Poster PresentationsKorkmaz G*, Lopes R*, Ugalde AP, Nevedomskaya E, Han R, Myacheva K, Zwart W, Elkon R, Agami R. “Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9”, Noncoding RNAs in Health and Disease, Keystone Symposia, Santa Fe, New Mexico, USA, 21-21 February 2016.Korkmaz G, Sage C, Tekirdag AK, Agami R and Gozuacik D. Microrna-376b controls autophagy by targeting Atg4C and Beclin 1. EACR, Cell Death in Cancer, Amsterdam, The Netherlands, 26-28 January 2012.Korkmaz G, Sage C, Agami R, Gozuacık D. Autophagy-regulating miR-B as a novel nanoparticle deliverable drug. 7th Nanoscience and Nanotechnology Conference, Sabanci University, Istanbul, Turkey, 27 June-01 July 2011.Korkmaz G, Sage C, Agami R, Gozuacık D. miRNA regulation of autophagy”. International Cell Death Society, Multidisciplinary Approaches in Cell Death Research From Yeast to Man, Antalya, Turkey, 28-31 May 2010.Korkmaz G, Agami R and Gozuacik D. miRNA regulation of autophagy. The 17th Euroconference on Apoptosis: Destruction, Degradation and Death, Institut Pasteur, Paris, France, 23-26 September 2009.Korkmaz G, Boz Y, Celik S, Budak H and Cetiner S. Molecular Analysis of Historical Wine Grape Variety Candidates Found in Urla. European Molecular Biology Organization (EMBO) International Forum, Bogazici University, Istanbul, Turkey, 20-22 February 2008.

Professional TrainingLearning Activity Postdoc Career Development Advanced Program - Influence and Impact (19.03.2018)Certificate – Postdoc training career program: “Workshop: Collaboration and Ownership” (09.02.2016)Certificate – Postdoc training career program: basic program (07.05.2015)Module 1-Strategic thinking and entrepreneurshipModule 2-Communication and cooperationModule 3-Creating your futureCertificate – Training Radiation Protection Level 5B (11.03.2013)Training Course – Testing Food and Feed Samples for the Presence of GMOs in Sofia, Bulgaria (25-29.06.2007)