curriculum vitae updated may 2015phydatabase.med.miami.edu/documents/cv/nawaz.zafar_2739_cv.pdf ·...

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CURRICULUM VITAE Updated May 2015

I. PERSONAL

Name: Zafar Nawaz

Home Phone:

Cellular Phone:

954-499-0531

954-632-7352

Office Phone:

Fax:

305-243-1456

305-243-6170

Home Address: 3850 Windmill Lakes Road

Weston, FL 33332

Current Academic Rank: Professor

Current Track of Appointment: Tenure

Primary Department: Biochemistry & Molecular Biology

University of Miami School of Medicine

Joint Appointment: UM/SCCC Braman Family Breast Cancer

Institute

Citizenship: United States of America

II. HIGHER EDUCATION

Institutional

December 1992- April 1995 Post Doctoral Fellow

Cell Biology, Baylor College of Medicine, Houston, Texas, USA.

Area of Research: To unravel the Molecular Mechanism of Action

of Nuclear Hormone Receptors with Specific Emphasis on

Estrogen and Progesterone Receptors, Coactivators and

Corepressors and to study the role of the ubiquitin-proteasome

pathway in steroid hormone receptor functions.

1987- 1992 Ph.D.

University of North Texas, Denton, Texas, USA.

Thesis: Molecular Mechanism of Action of Steroid Hormone

Receptors.

1983- 1985 Master of Science

University of Karachi, Pakistan

Major- Genetics

Minor- Bacterial Genetics

Thesis: Isolation, Characterization and Genetic Studies of

Rhizobium Species.

1981- 1983 Bachelor of Science, University of Karachi, Pakistan

Major- Biology

Minor- Chemistry

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III. EXPERIENCE

Academic

University of Miami Miller School of Medicine, Office of Graduate & Postdoctoral Studies, Senior

Associate Dean, July 2012 – Present.

University of Miami Miller School of Medicine, Department of Biochemistry and Molecular

Biology, Director BS/PhD Program (developed first of its kind in biological sciences in the

nation accelerated dual BS/PhD program), September 2011 – June 2012.


Biology, Professor, June 1, 2010 – Present.


Biology, Graduate Program Director, 2009 – June 2012.

University of Miami Miller School of Medicine SCCC Braman Family Breast Cancer Institute,

Associate Research Director, December 1, 2004 - To date.

Allama Iqbal Medical College, Lahore, Pakistan. Foreign Professor, January 2010 – Present.

University of the Punjab, Lahore, Pakistan. Foreign Professor, 2004 -Present.

Jilian University, China. Visiting professor, 2004 -To date.


Biology, Associate Professor, December 1, 2004 – May 31, 2010.

Creighton University, Omaha, Nebraska, Associate Professor-Department of Surgery, Medical

Microbiology & Immunology and Cancer Center, 2002 - 2004.

Creighton University, Omaha, Nebraska, Director, Cancer Center Molecular Biology Core Lab,

2002 - 2004.

Baylor College of Medicine, Houston, Texas, Assistant Professor - Department of Cell Biology,

1997 - 2002.

Baylor College of Medicine, Houston, Texas, Instructor - Department of Cell Biology, 1995 - 1997.

Baylor College of Medicine, Houston, Texas, Research Associate - Department of Cell Biology,

1989 – 1995.

University of the Punjab, Lahore, Pakistan, Lecturer - Center for Advanced Molecular Biology,

1986 – 1987.

University of the Punjab, Lahore, Pakistan, Research Fellow - Center for Advanced Molecular

Biology, 1985 – 1986.

IV. PUBLICATIONS

Books and Monographs (9 Book Chapters)

1. Buffa L and Nawaz Z. (2012) Estrogen receptor coregulators and breast cancer. In press for The

Research and Biology of Cancer. Editors: iConcept Press Ltd. Brisbane, Australia.

2. Sun J, Zhou W, Nawaz Z, Slingerland JM. (2011) Cross Talk between ERα and Src signaling and

its relevance to ER status and hormone responsiveness. In: Advances in Rapid Sex-Steroid Action:

New Challenges and New Chances in Breast and Prostate Cancers. Editors: Gabriella Castoria and

Antimo Migliaccio, Springer, New York.

3. Srinivasan S and Nawaz Z. (2009) Molecular biology of estrogen receptor. In: Molecular

Mechanisms of Hormone Actions on Behavior. Editors: Anne M. Etgen and Donald W. Pfaff.

Elsevier Inc.

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4. Srinivasan S, and Nawaz Z. (2009) Molecular Biology of Estrogen Receptor Action. In: Hormones,

Brain and Behavior, 2nd edition, Vol 2. Editors: Donald W. Pfaff, Arthur P. Arnold, Anne M.

Etgen, Susan E. Fahrbach and Robert T. Rubin. San Diego: Academic Press; pp. 1187-1218.

5. Ismail A., Catoe H., Dhananjayan S. and Nawaz Z. (2008) The Ubiquitin-Proteasome Pathway:

Regulation of Nuclear Hormone Receptor Functions. In: Nuclear Receptor Coregulators and

Human Diseases. Editors: Rakesh Kumar and Bert O’Malley. World Scientific Publishing Co. Pte.

Ltd. pp.163-193

6. McKenna N.J., Nawaz Z., Tsai S.Y., and Tsai M.J. (2000) Coactivators and Corepressors. In:

Principles of Molecular Regulation. Editors: P.M. Conn, and A.R. Means. Humana Press, Totowa,

New Jersey. pp.385-394.

7. Lonard, D.M., and Nawaz Z. (2000) Coactivators and Corepressors. In: Nuclear Receptors and

Genetic Disease. Editors; T.P. Burris and E. McCabe. Academic Press Ltd. pp. 389-408.

8. Nawaz Z., Smith D.W. and McDonnell D.P. (1991) Expression of Functional Vitamin D3 Receptor

in E. coli. In: Vitamin D; Gene Regulation, Structure-Function Analysis and Clinical Application.

Editors: A. W. Norman, R. Bouillon and M. Thomasset. Walter De Gruyter Inc. pp. 50-51.

9. Santiso-Mere D., Nawaz Z., McDonnell D.P. and O'Malley B.W. (1991) The Development of

Saccharomyces Cerevisiae as a Host System for Steroid Hormone Action Studies. In: Hormone

Action and Molecular Endocrinology, 15th edition. Editors: M. R. Huges, W. T. Schrader and B.

W. O'Malley. Houston Biological Associates Inc. pp. 23-1- 23-24.

Refereed Journal Articles (81 Articles)

1. Zhou W., Srinivasan S., Nawaz Z., and Slingerland J.M. 2013. ERα, SKP2 and E2F-1 form a feed

forward loop driving late ERα targets and G1 cell cycle progression. Oncogene. Jun 17 [Epub ahead

of print]

2. El Hokayem J. and Nawaz Z. 2014. E6AP in the Brain: One Protein, Dual Function, Multiple

Diseases. Mol. Neurobiol. 49(2):827-39. Cover article.

3. El Hokayem J. and Nawaz Z. 2013. The Transcriptional Coactivation Function of E6-Associated

Protein in the Brain: Novel Insights into the Pathobiology of Debilitating Neurogenetic Diseases.

Mol. Cell. [In Preparation]

4. Srinivasan S. and Nawaz Z. 2013. Transcriptional Profiling Reveals Cell Cycle Regulation by an

E3 Ligase Enzyme, E6-Associated Protein in Breast Cancer Cells. PLOS One. [Submitted]

5. Buffa L., Saeed A. and Nawaz Z. 2013. Molecular mechanism of WW-Domain Binding Protein-2

Coactivation Function in Estrogen Receptor Signaling. IUBMB. 65(1):76-84

6. Sun J., Zhou W., Kaliappan K., Nawaz Z. and Slingerland J.M. 2012. ERα phosphorylation at

Y537 by Src Triggers E6-AP-ERα Binding, ERα Ubiquitylation, Promoter Occupancy, and Target

Gene Expression. Mol. Endo. 26(9):1567-77

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7. McDonald C., Buffa L., Bar-Mag T., Salah Z., Bhat V., Mikles D.C., Deegan B.J., Seldeen K.L.,

Malhotra A., Sudol M., Aqeilan R.I., Nawaz Z. and Farooq A. 2012. Biophysical Basis of the

Binding of WWOX Tumor Suppressor to WBP1 and WBP2 Adaptors. J. Mol. Biol. 422(1):58-74.

8. Andreev V.P, Petyuk V., Brewer H., Karpievitch Y.V., Xie F., Clarke J., Camp D.G., Smith R.D.,

Lieberman A.P., Albin R.L., Nawaz Z., Hokayem J.E. and Myers A.J. 2012. Label-Free

Quantitative LC-MS Proteomics of Alzheimer’s Disease and Normally Aged Human Brains. J

Proteome Res. 2012 May 5. [Epub ahead of print]

9. Kausar H., Gull S., Ijaz B., Ahmad W., Sarwar MT., Iqbal Z., Nawaz Z., Riazuddin S. and Hassan

S. 2011. Huh-7 cell line as an alternative cultural model for the production of human like

erythropoietin (EPO). J Transl Med. 9(1):186.

10. Ashfaq U.A., Masoud M.S., Nawaz Z. and Riazuddin S. 2011. Glycyrrhizin as antiviral agent

against Hepatitis C Virus. J Transl Med. 9:112.

11. McDonald C., McIntosh S.K.N., Mikles D., Bhat V., Deegan B.J., Seldeen K.L., Saeed A.M., Buffa

L., Sudol M., Nawaz Z. and Farooq A. 2011. Biophysical Analysis of Binding of WW Domains of

the YAP2 Transcriptional Regulator to PPXY Motifs within WBP1 and WBP2 Adaptors.

Biochemistry. 50(44):9616-27.

12. Ramamoorthy S., Tufail R., El Hokayem J., Jorda M., Zhao W., Reis I. and Nawaz Z. 2011.

Overexpression of ligase defective E6-associated protein, E6-AP, results in mammary

tumorigenesis. Breast Cancer Research and Treatment 132(1):97-108.

13. Tufail R., Jorda M., Zhao W., Reis I. and Nawaz Z. 2011. Loss of Yes-associated protein (YAP)

expression is associated with estrogen and progesterone receptors negativity in invasive breast

carcinomas. Breast Cancer Research and Treatment. 131(3):743-50.

14. Catoe, H.W. and Nawaz, Z. 2011. E6-AP Facilitates p300 Recruitment to Estrogen Responsive

Promoter to Allow Efficient Transcription. Steroids. 76(9):897-902.

15. Abdeen S.K., Salah Z. Maly B., Smith Y., Tufail R., Abu-Odeh M., Zanesi N., Croce C.M., Nawaz

Z. and Aqeilan R.I. 2011. Wwox inactivation enhances mammary tumorigenesis.

Oncogene. 30(36):3900-6. doi: 10.1038/onc.2011.115.

16. Ashfaq U.A., Masoud M.S., Khaliq S., Nawaz Z. and Riazuddin S. 2011. Inhibition of Hepatitis C

Virus 3a genotype entry through Glanthus Nivalis Agglutinin. Virol J. 8:248.

17. Ashfaq U.A., Javed T., Rehman S., Nawaz Z. and Riazzudin S. 2011. Lysosomotropic agents as

HCV entry inhibitors. Virol J. 8(1):163.

18. Ashfaq U.A., Javed T., Rehman S., Nawaz Z. and Riazuddin S. 2011. An overview of HCV

Molecular biology, replication and immune responses. Virol J. 8:161.

19. Ashfaq U.A., Khan S.N., Nawaz Z. and Riazuddin S. 2011. In-vitro model systems to study

Hepatitis C Virus. Genet Vaccines Ther. 9:7.

20. Ashfaq U.A., Javed T., Rehman S., Nawaz Z. and Riazuddin S. 2011. Inhibition of HCV 3a core

gene through Silymarin and its fractions. Virol J. 8:15.

http://www.ncbi.nlm.nih.gov/pubmed/21981024



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21. Ramamoorthy S., Dhananjayan S.C., DeMayo F.J. and Nawaz Z. 2010. Isoform specific

degradation of PR-B by E6-AP is critical for normal mammary gland development. Mol.

Endocrinol. 24(11):2099-113.

22. Srinivasan S. and Nawaz Z. 2010. E3 Ubiquitin Protein Ligase, E6-Associated Protein (E6-AP)

Regulates PI3K-Akt Signaling and Prostate Cell Growth. Biochim Biophys Acta. 1809(2):119-27.

23. Fu W., Ma Q., Chen L., Li P., Zhang M., Ramamoorthy S., Nawaz Z., Shimojima T., Wang H.,

Yang Y., Shen Z., Zhang Y., Zhang X., Nicosia S.V., Zhang Y., Pledger J.W., Chen J. and Bai W.

2009. MDM2 Acts Downstream of p53 as an E3 Ligase to Promote FOXO Ubiquitination and

Degradation. J Biol Chem. 284(21):13987-4000.

24. Ramamoorthy, S., and Nawaz, Z. 2008. E6-associated protein is a dual function coactivator of

steroid hormone receptors. The Nuclear Receptor Signaling. 6:e006.

25. Sun J., Nawaz Z. and Slingerland J. 2007 Long-Range Activation of GREB1 by Estrogen Receptor

via Three Distal Consensus Estrogen-Responsive Elements in Breast Cancer Cells. Mol

Endocrinol. 21(11): 2651-2662.

26. Chu I., Arnaout A., Loiseau S., Sun J., Seth A., McMahon C., Chun K., Hennessy B., Mills G.B.,

Nawaz Z. and Slingerland J. 2007 Src promotes estrogen-dependent estrogen receptor alpha

proteolysis in human breast cancer. J Clin Invest.; 117(8):220.

27. Burjonrappa S.C., Reddimasu S., Nawaz Z., Gao X., Sharma P. and Loggie B. (2007) Mucin

expression profile in Barrett's, dysplasia, adenocarcinoma sequence in the esophagus.

Indian J Cancer, 44(1):1-5.

28. Rapuri P.B., Gallagher J.C., and Nawaz Z. (2007) Caffeine decreases vitamin D receptor protein

expression and 1,25(OH)(2)D(3) stimulated alkaline phosphatase activity in human osteoblast

cells. J Steriod Biochem Mol Biol., 103(3-5):368-71.

29. Dhananjayan S.C., Ramamoorthy S., Khan O.Y., Ismail A., Sun J., Slingerland J., O'Malley B.W.,

and Nawaz Z.. (2006) WW-domain binding protein-2 (WBP-2), an E6-AP interacting protein acts

as a coactivator of estrogen and progesterone receptors. Mol. Endocrinol., 20(10):2343-54.

30. Khan O.Y., Fu G., Ismail A., Srinivasan S., Cao X., Tu Y., Lu S. and Nawaz Z. (2006)

Multifunction steroid receptor coactivator, E6-associated protein, is involved in development of the

prostate gland. Mol Endocrinology, 20(3):544-59.

31. Wu J., Liang Y., Nawaz Z., and Hyder S.M. (2005) Complex agonist-like properties of ICI 182,780

(Faslodex) in human breast cancer cells that predominantly express progesterone receptor-B:

implications for treatment resistance. International Journal of Oncology, 27(6):1647-59.

32. Dhananjayan S., Ismail A. and Nawaz Z. (2005) Ubiquitin and the control of transcription. Essays

in Biochem., 41:69-80. Review.

33. Ismail A. and Nawaz N. (2005) Nuclear hormone receptor degradation and gene transcription: An

Update. IUBMB Life Sciences, 57(7):483-90. Review.

34. Dennis A.P., Lonard D.M., Nawaz Z., O'Malley B.W. (2005) Inhibition of the 26S proteasome

blocks progesterone receptor-dependent transcription through failed recruitment of RNA

polymerase II. J Steroid Biochem Mol Biol., 94(4):337-46.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16254014&query_hl=2&itool=pubmed_docsum



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35. Gao X., Mohsin S.K., Gatalica Z., Fu G., Sharma P., and Nawaz Z. (2005) Decreased expression

of e6-associated protein in breast and prostate carcinomas. Endocrinology, 146(4):1707-12.

36. Verma S., Ismail A., Li X., O’Malley B.W. and Nawaz Z.. (2004) Ubiquitin-Conjugating Enzyme,

UBCH7 acts as a coactivator for steroid hormone receptors. Mol Cell Biol., 24(19):8716-26.

37. Liu Z., Shi H.Y., Nawaz Z. and Zhang M. (2004) Tamoxifen induces the expression of maspin

through estrogen receptor-alpha. Cancer Lett., 209: 55-65.

38. Nawaz Z. and O’Malley B.W. (2004) Urban Renewal In The Nucleus: Is Protein Turnover by

Proteasomes Required for Transcription? Mol. Endo., 18(3):493-9. Review.

39. Khan O.Y. and Nawaz Z. (2003) Nuclear hormone receptor co-regulators. Current Opinion in

Drug Discovery & Development, 6(5):692-701. Review.

40. Yan F., Gao X., Lonard D. and Nawaz Z. (2003) Specific ubiquitin-conjugating enzymes promote

degradation of specific nuclear receptor coactivators. J Steroid Biochem Mol Biol., 17(7):1315-31.

41. Pearce V., Nawaz Z., Xiao W., Wiedenfled D., Boyle N. and Smith D. (2003) 4-

Ethoxymethylphenol: A novel estrogen that acts as an agonist for human estrogen receptors. Steroid

Biochem. And Mol. Biol., 84: 431-439.

42. Gao X., Loggie B.W. and Nawaz Z. (2002) The roles of sex steroid receptor coregulators in cancer.

Molecular Cancer, 1: 1-7.

43. Gao X. and Nawaz Z. (2002) Role of steroid receptor coactivators and corepressors of progesterone

receptors in breast cancer. Breast Cancer Res., 4(5):182-6.

44. Smith C.L., DeVera D.G., Lamb D.J., Nawaz Z., Jiang Y.H., Beaudet A.L. and O’Malley B.W.

(2002) Genetic Ablation of the Steroid Receptor Coactivator-Ubiquitin Ligase, E6-AP, Results in

Tissue-Selective Steroid Hormone Resistance and Defects in Reproduction. Molecular and

Cellular Biology, 22(2):525-35.

45. Dennis A.P., Haq R.U., and Nawaz Z. (2001) Importance of the regulation of nuclear receptor

degradation. Front. Bioscience, 6:D954-9.

46. Zhao H., Herrera R.E., Coronado-Heinsohn E., Yang M.C., Ludes-Meyers J.H., Seybold-Tilson

K.J., Nawaz Z., Yee D., Barr F.G., DiabS.G., Brown P.H., Fuqua S.A., and Osborne C.K. (2001)

Forkhead homologue in rhabdomyosarcoma functions as a bifunctional nuclear receptor-

interacting protein with both coactivator and corepressor functions. J Biol Chem., 276(30):27907-

12.

47. Sivaraman L., Nawaz Z., Medina D., Conneely O.M., and O’MalleyB.W. (2000) The novel dual

function steroid receptor coactivator/ubiquitin protein-ligase integrator E6-AP is overexpressed in

mouse mammary tumorigenesis. Breast Cancer Research and Treatment, 62(3):185-95.

48. Hyder S.M., Huang J.C., Nawaz Z., Tong H.B., Makela S., Chiappetta C. and Stancel G. (2000)

The Regulation of vascular endothelial growth factor expression by estrogens and progestins.

Environmental Health Prospectives, 108 Suppl 5:785-90.

49. Li J., Wang J., Wang J., Nawaz Z., Liu J.M., Qin J., and Wong J. (2000) Both corepressors SMRT

and N-CoR proteins exist in large protein complexes containing HDAC3. EMBO, 19(16):4342-50.

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50. *Lonard D.M., *Nawaz Z., Smith C.L., and O’Malley B.W. (2000) The 26S proteasome is required

for estrogen receptor- and coactivator turnover and for efficient estrogen receptor-

transactivation. Molecualr Cell, 5(6):939-48.

*Equal contribution.

51. Hyder S.M., Nawaz Z., Chiappetta C., and Stancel G. (2000) Detection of classical and atypical

estrogen response elements in the untranslated regions of the rat VEGF gene. Cancer Research,

60(12):3183-90.

52. McKenna N.J., Xu J., Nawaz Z., Tsai S.Y., Tsai M.J. and O’Malley B.W. (1999) Nuclear receptor

coactivator: Multiple enzymes, multiple complexes, multiple functions. J. Steroid Biochem. Mol.

Bio., 69(1-6):3-12.

53. Robinson C.E., Wu X., Nawaz Z., Onate S.A. and Gimble J.M. (1999) A corepressor and chicken

ovalbumin upstream promoter transcription factor proteins modulate peroxisome proliferator-

activated receptor-gamma2/retinoid X receptor alpha-activated transcription from the murine

lipoprotein lipase promoter. Endocrinology, 140(4):1586-93.

54. Nawaz Z., Lonard D. M., Dennis A. P., Smith C. L. and O’Malley B.W. (1999) Proteasome-

dependent degradation of the human estrogen receptor. Proc. Natl. Acad. Sci. USA, 96(5):1858-

62.

55. Nawaz Z., Standcel G.M. and Hyder S.M. (1999) The pure antiestrogen ICI 182780 inhibits

progestin-induce transcription. Cancer Res., 59(2):372-6.

56. Nawaz Z., Lonard D.M., Smith C.L., Lev-Lehman E., Tsai S.Y., Tsai M.J. and O’Malley B.W.

(1999) The Angelman syndrome-associated gene, E6-AP, is also a coactivator for nuclear hormone

receptor superfamily. Mol. Cell. Bio., 19(2):1182-9.

57. McKenna N.J., Nawaz Z., Tsai S.Y., Tsai M.J. and O’Malley B.W. (1998) Distinct steady state

nuclear receptor coregulator complexes exist in vivo. Proc Natl Acad Sci U S A. 95(20):11697-702.

58. Shibata H., Nawaz Z., Tsai S.Y., O’Malley B.W. and Tsai M.J. (1997)Gene silencing by chicken

ovalbumin upstream promoter-transcription factor I (COUP-TFI) is mediated by transcriptional

corepressors, nuclear receptor-corepressor (N-CoR) and silencing mediator for retinoic acid

receptor and thyroid hormone receptor (SMRT). Mol Endocrinol. 11(6):714-24.

59. Smith C.L., Nawaz Z. and O’Malley B.W. (1997) Coactivator and corepressor regulation of the

agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen. Mol Endocrinol.

11(6):657-66.

60. Xu J., Nawaz Z., Tsai S.Y., Tsai M.J. and O’Malley B.W. (1996) The extreme carboxyl-terminus

of progesterone receptor contains a transcriptional repressor domain that functions through a

putative corepressor. Proc Natl Acad Sci U S A. 93(22):12195-9.

61. Nawaz Z., Tsai M.J. and O’Malley B.W. (1995) Specific mutations in the ligand binding domain

selectively abolish the silencing function of human thyroid receptor ß. Proc. Natl. Acad. Sci. USA.,

92(25):11691-5.

62. Burris T.P., Nawaz Z., Tsai M.J. and O'Malley B.W. (1995) A nuclear hormone receptor-

associated protein that inhibits transactivation by the thyroid hormone and retinoic acid receptors.

Proc. Natl. Acad. Sci. USA, 92(21):9525-9.

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63. Hyder S., Nawaz Z., Chiappetta C., Yokoyama K. and Stancel G.M. (1995) Protooncogene c-jun

contains an unusual estrogen inducible enhancer within the coding sequences. J. Biol. Chem.,

92(21):9525-9.

64. Baniahmad C., Nawaz Z., Baniahmad A., Gleeson M., Tsai M.J. and O'Malley B.W. (1995)

Enhancement of human estrogen receptor activity by SPT6: A potential Co-activator. Mol. Endo.,

9(1):34-43.

65. Nawaz Z., Baniahmad C., Stillman D.J., Burris T., O'Malley B.W. and Tsai M.J. (1994) The yeast

SIN3 gene negatively regulates the activity of the human progesterone receptor and positively

regulates the activities of GAL4 and the HAP1 activator. Mol. General Genetics, 245(6):724-33.

66. Fuqua S.A.W., Allred D.C., Elledge R.M., Krieg S.L., Benedix M.G., Nawaz Z., O'Malley B.W.,

Green G.L. and McGuire W.L. (1993) The ER-positive/ PgR-negative breast cancer phenotype is

not associated with mutations within the DNA binding domain. Breast Cancer Res. and Treatment,

26(2):191-202.

67. Nawaz Z., Stancel G.M., McDonnell D.P. and Hyder S.M. (1993) Creation of an active estrogen-

responsive element by a single base change in the flanking sequence of a cellular oncogene: A

possible mechanism for hormonal carcinogenesis? Mol. Carcinogenesis, 7(2):76-82.

68. Hyder S.M., Stancel G.M., Nawaz Z., McDonnell D.P. and Loose-Mitchell D.S. (1992)

Identification of an estrogen response element in the 3'-flanking region of the murine c-fos

protooncogene. J. Biol. Chem., 267(25):18047-54.

69. Nawaz Z., Tsai M.J., McDonnell D.P. and O'MalleyB.W. (1992) Identification of novel steroid

responsive elements. Gene Expression, 2(1):39-47.

70. Fuqua S.A.W., Fitzgerald S.D., Allred D.C., Elledge R.M., Nawaz Z., McDonnell D.P., O'Malley

B.W., Green G.L. and McGuire W.L. (1992) Inhibition of estrogen receptor action by naturally

occurring variant in human breast tumors. Cancer Res., 52(2):483-6.

71. McDonnell D.P., Nawaz Z. and O'Malley B.W. (1991) In situ distinction between steroid receptor

binding and transactivation at a target gene. Mol. Cell. Bio., 11(9):4350-5.

72. McDonnell D.P., Nawaz Z., Densmore C., Weigal N.L., Pham T.A., Clark J.H. and O'Malley B.W.

(1991) High level expression of biologically active estrogen receptor in Saccharomyces cerevisiae.

J. Steroid Biol. and Mol. Biol, 39(3):291-7.

73. Pham T.A., Elliston J.F., Nawaz Z., McDonnell D.P., Tsai M.J. and O'MalleyB.W. (1991)

Antiestrogen can established nonproductive receptor complexes and alter chromatin structure at

target enhancers. Proc. Natl. Acad. Sci. USA. 88(8):3125-9.

74. Fuqua S.A.W., Fitzgerald S.D., Chamness G.C., Tandon A.K., McDonnell D.P., Nawaz Z.,

O'Malley B.W. and McGuire W.L. (1991) Variant human breast tumor estrogen receptor with

constitutive transcriptional activity. Cancer Res., 51(1):105-9.

75. Witliff J.L., Wenz L.L., Dong J., Nawaz Z. and Butt T.R. (1990) Expression and characterization

of an active human estrogen receptor as a ubiquitin fusion protein from Escherichia coli. J. Biol.

Chem., 265(35):22016-22.

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76. Riazuddin S., Sohail A. and Nawaz Z. (1987) Isolation of temperate bacteriophage phi R7 specific

for Pseudomonas aeruginosa. Pak. J. of Zool., 19(3), 290-298.

77. Raufa A., Nawaz Z., Riazuddin S. and Shakoori A.R. (1987) Isolation, characterization and genetic

studies of Rhizobium meliloti. Pak. J. of Zool., 19(2), 120-124.

78. Neelam M., Nawaz Z. and Riazuddin S. (1987) Hydrocarbon Biodegradation: Biochemical

characterization of bacteria isolated from local soils. Pak. J. of Sci. and Indus., Res. 30, 282-285.

79. Neelam M., Nawaz Z., Shakoori A.R. and Riazuddin S. (1987) Isolation and characterization of

R- factor (plasmids) from antibiotic resistant strains collected from local hospitals. Pak. J. of Zool.,

19(1), 17-26.

80. Nawaz Z. and Ahmad N. (1987) Isolation and characterization of Rhizobium species as nitrogen

fixing symbionts in Guar (Cymopsis tetragonoloba (L) Taub). Pak. J. of Zool., 19(1), 9-15.

81. Riazuddin S., Shakoori A.R. and Nawaz Z. (1986) Mutagenicity testing of children’s consumables.

Pak. J. of Zool., 18(3), 325- 334.

Abstracts

1. El Hokayem J. and Nawaz Z. 2014. The transcriptional coactivation function of E6AP in Angelman

syndrome and related diseases. Miami Winter Symposium 2014, Miami, FL

2. El Hokayem J., Garcia A., Obeid J.P., Weeber E. and Nawaz Z. 2012. The Angelman Syndrome

protein E6AP transcriptionally regulates the expression of the retinoic acid catabolizing enzyme

CYP26B1 through Estrogen Receptor Signaling. FASEB, Snowmass Village, CO

3. El Hokayem J., Garcia A., Obeid J.P., Weeber E. and Nawaz Z. 2012. The Angelman Syndrome

protein E6AP transcriptionally regulates the expression of the retinoic acid catabolizing enzyme

CYP26B1 through Estrogen Receptor Signaling. Endocrine Society Annual Meeting. Houston, TX

4. Buffa L. and Nawaz Z. 2012. Molecular mechanism of WBP-2 coactivation function in Estrogen

Receptor transactivation. AACR annual Meeting. Chicago, IL

5. El Hokayem J. and Nawaz Z. 2011. The Angelman Syndrome protein E6AP transcriptionally

regulates the expression of the retinoic acid metabolizing enzyme CYP26B1 through Estrogen

Receptor Signaling. Keystone Symposia: Environmental Epigenomics. Asheville, NC

6. Srinivasan S. and Nawaz Z. 2010. Steroid Hormone Receptor Coactivator, E6-Associted Protein

(E6-AP) Regulates PI3K-Akt Signaling and Cell Growth. FASEB, Snowmass Village, CO

7. Catoe H.W. and Nawaz Z. 2010. E6-AP Facilitates p300 Recruitment to an Estrogen Responsive

Promoter to Allow Efficient Transcription. Endocrine Society Annual Meeting. San Diego, CA

8. Kilroy G., Burk D.H., Ramamoorthy S., Nawaz Z. and Floyd E. 2010. Identification of Ubiquitin

Ligases that Regu

SUMO, Ubiquitin, UBL Proteins: Implications for Human Diseases. Houston, TX.

9. Ramamoorthy S. and Nawaz Z. 2009. RE6-AP Mediated Proteolysis of PR-B Regulates Mammary

Gland Tumorigenesis by Modulating the Wnt Signaling Pathway. Endocrine Society Annual

Meeting. Washington, D.C.

10

10. Srinivasan S., Pedroso I.M. and Nawaz Z. 2009. Role of E6-AP in Estrogen Dependent

Transcriptome of MCF-7 Breast Cancer Cells. Endocrine Society Annual Meeting. Washington,

D.C.

11. Dhananjayan S., Ramoorthy S. and Nawaz Z. 2008. WWOX, a Tumor Suppressor Negatively

Regulates the Coactivation Functions of WBP-2 and Oncoprotein YAP. Cold Spring Harbor Lab,

NY.

12. Ramamoorthy S., Dhananjayan S. and Nawaz Z. 2008. E6-Associated Protein (E6-AP) Regulates

Mammary Gland Morphogenesis by Modulating the Ubiquitin-Mediated Proteolysis of the

Progesterone Receptor. Cold Spring Harbor Lab, NY.

13. Dhananjayan S., Ramamoorthy S. and Nawaz Z. 2008. WWOX, a Tumor Suppressor Negatively

Regulates the Coactivation Functions of WBP-2 and Oncoprotein YAP. DOD – Era of Hope

Meeting.

14. Srinivasan S., Ismail I., Rudd K.E., Zhou J. and Nawaz Z. 2008. Genome Wide Analysis of

Estrogen DependentE6-AP Binding Sites in MCF-7 Breast Cancer Cells. Endocrine Annual

Meeting.

15. Ramamoorthy S., Dhananjayan S.C., Zafar S. and Nawaz Z. 2007. E6-Associateed Protein is a Cell

Growth Regulator in Mammary Gland. The Endocrine Society Annual Meeting.

16. Dhananjayan S.C., Ramamoorthy S. and Nawaz Z. 2007. Oncogenic WW-domain containing

oxidoreductase negatively regulates the coactivation functions of WW-domain binding protein-2

and yes-associated protein 1. The Endocrine Society Annual Meeting.

17. Srinivasan S., Zafar S. and Nawaz Z. 2007. Transcriptional Regulation of MUC2 by Estrogen.

ASCO Gastrointestinal Cancers Symposium.

18. Zafar S., Srinivasan S. and Nawaz Z. 2007. E6-associated protein (E6-AP): A potential tumor

suppressor protein. AACR Annual Meeting.

19. Fu G., Srinivasan S., Dhananjayan S., Zafar S. and Nawaz Z. 2007. Steroid Hormone Receptor

Coactivator, E6-Associated Protein (E6-AP) Regulate P13K-Akt Signaling and Prostate Cell

Growth. AACR Annual Meeting.

20. Zafar S., Srinivasan S. and Nawaz Z. 2007. E6-Associated Protein (E6-AP): A Potential Tumor

Suppressor Protein. AACR Annual Meeting.

21. Srinivasan S., Zafar S., Nawaz Z. and Loggie B.W. 2006. Transcriptional Regulation of MUC2 by

Estrogen. ASCO GI Annual Meeting.

22. Zafar S., Srinivasan S., and Nawaz Z. 2006. E6-Associated Protein (E6-AP): A Potential Tumor

Suppressor Protein for Colorectal Cancer. ASCO GI Annual Meeting.

23. Zafar S., Srinivasan S. and Nawaz Z. 2006. E6-Associated Protein (E6-AP): A Potential Tumor

Suppressor Protein for Non-Hodgkin Lymphoma. ASH Annual Meeting.

24. Dhananjayan S., Khan O.Y. and Nawaz Z. 2005. Identification and characterization of WW-

domain binding proteins as E6-AP interacting proteins and their role in steroid hormone receptor

functions. The Endocrine Society Annual Meeting.

11

25. Srinivasan S., Khan O.Y., Fu G., Ismail A., Tu Y., Lu S. and Nawaz Z. 2005. Multifunction steroid

receptor coactivator, E6-associated protein, E6-AP is involved in development of the prostate

gland. The Endocrine Society Annual Meeting.

26. Nawaz Z. 2004. Ubiquitin-Conjugating Enzyme, UBCH7 Modulates Steroid Hormone Receptor

Functions. 2nd Ubiquitin Conference.

27. Verma S., Ismail A., Li X., O’Malley B.W. and Nawaz Z. 2004. Ubiquitin-Conjugating Enzyme,

UBCH7 modulates steroid hormone receptor function by forming a multiprotein complex with

SRC-1 and E6-AP. Key Stone Symposia on Nuclear hormone receptors.

28. Loggie B.W., Nawaz Z., Gatalica Z., Silvaand E., and El-Ella G.A. 2004. Inhibition of Mucin 2

production: Implications for treatment of Pseudomyxoma Peritonei. The Surgical Society of

Oncology.

29. El Ella G.A., Gatalica Z. and Nawaz Z. 2004. Inhibition of Mucin production: Implications for

treatment of breast cancer. AACR Meeting.

30. Zafar S., Gao X., Khalid M., Gatalica Z. and Nawaz Z. 2004. E6-associated protein, E6-AP is

involved in the carcinogenesis of human breast and prostate. AACR Meeting.

31. Loggie B.W., El-Ella G.A., Gatalica Z., Silvaand E. and Nawaz Z. 2003. Promising new strategies

for treatment of Pseudomyxoma Peritonei. The Surgical Society of Oncology.

32. Nawaz Z. 2003. Steroid hormone receptor coregulators. Nuclear Receptors as Drug Targets.

33. Verma1 S., Li X., O’Malley B.W. and Nawaz Z. 2003. Ubiquitin Conjugating Enzyme, UBCH7

Act As a Coactivator For Steroid Hormone receptors. The Endocrine Society.

34. Nawaz Z. 2003. Role of Ubiquitin-Proteasome Pathway Enzymes in Steroid Hormone Receptors

Transactivation. NIH meeting on Ubiquitin and Ubiquitin like pathways.

35. Ul Haq R. and Nawaz Z. 2002. Identification and characterization of WW-domain binding proteins

as E6-AP interacting proteins and their role in steroid hormone receptor functions. The Endocrine

Society.

36. Gao X., Mohsin S.K., Wheeler T.M., Yan F. and Nawaz Z. 2002. E6-associated protein, E6-AP,

is involved in the tumorigenesis of both mammary gland and prostate gland. The Endocrine

Society.

37. Verma S., Liu Z., Haq R., O’Malley B.W. and Nawaz Z. 2002. UBCH7, an E2 ubiquitin-

comjugating enzyme: Its possible role in the steroid receptor transactivation. The Key Stone

Symposia.

38. Hopp T.A., Wang C., Pestell R.G., Nawaz Z., Wang M. and Fuqua S.A.W. 2001. A hypersensitive

mutation of estrogen receptor a occurring in premalignant breast disease influences co-activator

binding, receptor acetylation, and stability. The Endocrine Society.

39. Gao X. and Nawaz Z., 2001. The nuclear hormone receptor coactivator, E6-AP is overexpressed

in human mammary tumors. The Endocrine Society.

12

40. Hopp T., Allred D.C., Hilsenbeck S., Mohsin S., Nawaz Z., O’Connell P., Pestell R.G. and Fuqua

41. O’Malley B.W., Xu J., Nawaz Z., Lanz R., Barron N., Liu Z., Rowen B., Cavarretta I., Smith C.,

Wong J., Tsai S. and Tsai M.J.. 2000. In vivo roles of steroid receptor coactivators in gene

regulation. The Endocrine Society.

42. Barron N., Nawaz Z., Qin J. and O’Malley B.W. 2000. Effects of the Ccr4/Not complexes on

steroid receptor-dependent transcription. The Endocrine Society.

43. Smith C., De Vera D., Nawaz Z., Jiang Y.H., Beaudet A.L. and O’Malley B.W.. 2000. A null

mutation of the steroid receptor coactivator/ubiquitin ligase E6-AP, negatively impact selected

tissues of the male and female reproductive tract in mice. . The Endocrine Society.

44. Dennis A., Nawaz Z. and O’Malley B.W. 2000. Characterization of UBA3: A novel type of nuclear

hormone receptor coactivator. The Endocrine Society.

45. Nawaz Z., Lonard D.M., Smith C.L. and O’Malley B.W. 2000. Regulation of Gene Expression by

the Nuclear Hormone Receptor-Coactivator Complex Requires the Ubiquitin-Proteasome Pathway.

The Endocrine Society.

46. O’Malley B.W., Xu J., Nawaz Z., Lanz R., Wu R., Leonard D.M., Liu Z., Cavarretta I., Smith C.,

Wong J., Tsai S. and Tsai M.J. 2000. Roles of steroid receptor co-activators in transcriptional

regulation in vitro and in vivo. The Key Stone Symposia.

47. Cox G.W., Nawaz Z. and Johnson G.V.W. 2000. Analysis of a unique nuclear transglutaminase

(TGase) substrate expressed in macrophages. American Association of Immunology Meeting.

48. Lonard D.M., Smith C.L., Nawaz Z. and O’Malley B.W. 2000. Ligand-mediated down-regulation

of estrogen receptor-alpha depends upon intact AF-2 coactivator-binding surfaces. The Key Stone

Symposia.

49. Nawaz Z. and O’Malley B.W. 2000. The Nuclear Hormone Receptor Coactivators are Targets of

the Ubiquitin-Proteasome Pathway. The Key Stone Symposia.

50. O’Malley B. W., Lanz R., Xu J., Nawaz Z., Lonard D., Smith C. L., Tsai S. Y., and Tsai M. J.

1999. Role of steroid receptor coactivators in transcriptional regulation. The Endocrine Society.

51. Hyder S. Nawaz Z., and Stancel G. 1999. A novel antiprogestin activity associated with the pure

antiestrogen ICI 182,780: Inhibition of progesterone receptor mediated gene expression. The

Endocrine Society.

52. Hyder S. M., Chiappetta, Nawaz, Z., and Stancel G. 1999. Detection of two estrogen receptor

binding sites located in the 5’ and 3’ untranslated regions of the VEGF gene. The Endocrine

Society.

53. Zhao H.H., Heinsohn E.C., Tilson K.S., Yang M.C., Ludes-Meyers J.H., Nawaz Z., Herrera R.E.,

Yee D., Brown P.H., Diab S.G., Barr F.G., O’Malley B.W., Fuqua S.A.W. and Osborne K. 1999.

FKHR, a bifunctional nuclear receptor intermediary protein, inhibits estrogen-dependent human

breast cancer cell growth. The Endocrine Society.

13

54. Nawaz Z., Lonard D.M., Dennis A. P., Smith C.L., and O’Malley B.W. 1999. Proteasome-

dependent degradation of the human estrogen receptor. The Endocrine Society.

55. Zhao H.H., Heinsohn E.C., Tilson K.S., Yang M.C., Nawaz Z., Herrera R.E., Yee D., Brown P.H.,

Diab S.G., Barr F.G., O’Malley B.W., Fuqua S.W.A. and Osborne K. 1999. FKHR, a novel nuclear

receptor interacting protein that functions as both a coactivator and corepressor. AACR Meeting

(The Steroid Receptor Superfamily).

56. Lonard D.M., Nawaz Z., Smith C.L. and O’Malley B.W. 1999. Involvement of ubiquitin-

proteasome mediated protein degradation in steroid receptor function. AACR Meeting (The Steroid

Receptor Superfamily).

57. Hyder S., Nawaz Z., Stancel G.M. 1999. The pure antiestrogen ICI182,780 exhibits a novel

antiprogestin activity and inhibits progesterone receptor dependent gene expression. AACR Annual

Meeting.

58. Lehman E.L., Nawaz Z., Benton C., Dicks D. and Beaudet A. 1998. Analysis of mutations causing

Angelman Syndrome: mRNA stability and UBA3 activity. American Society of Human Genetics.

59. Nawaz Z., Lonard D., Smith C.L., Tsai S.Y., Tsai M.J. and O’Malley B.W. 1998. The angelman

syndrome-associated gene, E6-AP, is a coactivator for nuclear hormone receptor superfamily. The

Endocrine Society.

60. Lonard D., Nawaz Z., Smith C.L., Tsai S.Y., Tsai M.J. and O’Malley B.W. 1998. The ubiquitin-

protein ligase E6-AP, mutated in angelman syndrome, is a steroid receptor coactivator. The Key

Stone Symposia.

61. Nawaz Z., Lonard D., Smith C.L., Tsai S.Y., Tsai M.J. and O’Malley B.W. 1998. The angelman


Key Stone Symposia.

62. Smith C.L., Nawaz Z., and O’Malley B.W. 1997. Transcriptional coregulators modulate the

relative ability of a mixed agonist/ antagonist, 4-hydroxytamoxifen to activate the estrogen

receptor. The Endocrine Society.

63. Shibata H., Nawaz Z., Tsai S.Y., O’Malley B.W. and Tsai M.J. 1997. Gene silencing by COUP-

TFI mediated by transcriptional corepressors N-CoR and SMRT. The Endocrine Society.

64. Shibata H., Nawaz Z., Tsai M.J. and O’Malley B.W. 1996. Cloning of corepressors for the thyroid

hormone receptor with yeast two-hybrid system. The Endocrine Society.

65. Nawaz Z., Tsai M.J. and O’Malley B.W. 1996. Specific mutations in the ligand binding domain

selectively abolish the silencing function of human thyroid receptor ß. The Key Stone Symposia.

66. Burris T.P., Nawaz Z., Tsai S.Y., Tsai M.J. and O'Malley B.W. 1995. Interaction cloning of a

protein, TRIP, which inhibits transactivation by the thyroid hormone and retinoic acid receptors.

The Endocrine Society.

67. Chiappetta C., Nawaz Z., Stancel G.M., and Hyder S.M. 1994. Different nucleotide requirements

for estrogen receptor binding and hormone dependent transcriptional activation defines a novel

estrogen responsive element within the coding sequence of c-jun. IX International Congress on

Hormonal Steroids.

14

68. Nawaz Z., Stillman D., Burris T., O'Malley B.W. and Tsai M.J. 1994. The yeast SIN3 gene

negatively regulates the transcriptional activity of the human progesterone receptor and positively

regulates the activities of GAL4 and the HAP1 activator. The Endocrine Society.

69. Hyder S.M., Nawaz Z. and Stancel G.M. 1993. A single base change in the flanking sequence of

a cellular oncogene creates an active estrogen response element- A possible mechanism of

hormonal carcinogenesis? The Endocrine Society.

70. Baniahmad C., Nawaz Z., Tsai M.J. and O'Malley B.W. 1992. Identification and isolation of co-

activator for steroid hormone receptors using a yeast host system. Santa Cruiz Summer Conference.

71. Hyder S.M., Loose-Mitchell D.S., Nawaz Z. and Stancel G.M. 1992. A 32 base pair

deoxyoligonucleotide derived from murine c-fos protooncogene binds estrogen receptor. The

Endocrine Society.

72. Fuqua S.A.W., Allred D.C., McDonnell D.P., Nawaz Z., O'Malley B.W., Green G.L. and McGuire

W.L. 1992. A dominant-positive variant estrogen receptor conferes resistance to endocrine therapy

in human breast cancer cells. The Endocrine Society.

73. Paslidis N., Baniahmad C., Nawaz Z., McDonnell D.P., Tsai M.J. and O'Malley B.W. 1992.

Identification of an 102 KDa protein which interacts with the estrogen receptor in yeast. American

Association of Cancer Research.

74. Nawaz Z., Tsai M.J., McDonnell D.P. and O'Malley B.W. 1992. A system to identify novel steroid

response elements. ASBMB/Biophysical Society.

75. Fuqua S.A.W., Allred D.C., Qui M., Fitzgerald S.D., Benedix M.G., Krieg S.L., McDonnell D.P.,

Nawaz Z., O'Malley B.W., Green G. and McGuire W.L. 1991. Transcriptionally active estrogen-

independent variant estrogen receptors in human breast tumors. Breast Cancer Symposium.

76. Nawaz Z., McDonnell D.P. and O'Malley B.W. 1991. A novel system to identify steroid responsive

elements. Eight Workshop on Vitamin D.

77. Nawaz Z., Smith D.W., McDonnell D.P. and O'Malley B.W. 1991. Expression of functional

vitamin D3 receptor in E. coli. Eight Workshop on Vitamin D.

78. Fuqua S.A.W., Allred D.C., Elledge R.M., Green G.L., Nawaz Z. and McGuire W.L. 1991

Estrogen receptor mRNA variants in breast cancer. The Endocrine Society.

79. McDonnell D.P., Nawaz Z. and O'Malley B.W. 1991. In situ distinction between steroid receptor

binding and transactivation at a target gene. The Endocrine Society.

80. Densmore C.L., McDonnell D.P., Nawaz Z. and Clark J.H. 1990. Expression and characterization

of human estrogen receptor in yeast Saccharomyces cerevisiae. The Cell Biology Society.

81. Fuqua S.A.W., McDonnell D.P., Nawaz Z., O'Malley B.W. and McGuire W.L. 1990. Variant

estrogen receptor RNA transcripts in breast tumors. The Endocrine Society.

82. Butt T.R., McDonnell D.P., Nawaz Z., Bowdin L., Green G. and Drutz D. 1989. Human estrogen

receptor expression in yeast and its regulation by non-steroidal ligands. Yeast Cell Biology. Cold

Spring Harbour.

15

V. PROFESSIONAL

Funded Research Performed

Active Grants

University of Miami Sylvester Comprehensive Cancer Center

Title: “Role of WWOX1 in Estrogen Receptor Level and Function in Breast Cancer”

Funding Period: 2014

Role: PI

Annual Direct: $50,000

Karen Mullen Breast Cancer Foundation

Title: “A Phase II clinical trial of Bortezomib (Velcadeᵀᴹ) in combination with tamoxifen in the

treatment of patients with metastatic triple negative breast cancer previously treated with

chemotherapy”

Funding Period: 2013 – 2015

Role: Co-PI


Total Annual Cost: $50,000

Foundation for Angelman Syndrome Therapeutics GIA2012005 [Grant in aid]

Title: “E6-AP transcriptional targets in the pathogenesis and therapy of AS”

Funding Period: 2/1/2013 – 1/31/2014

Role: PI

Annual Direct: $ 41,460

Total Annual Cost: $ 41,460

NIH-NIDDK RO1 1R01DK079217-01A2

Title: “Roles of Novel Protein Complexes in Estrogen and Progesterone Receptor Signaling”

Funding Period: 1/1/2009 – 12/31/2013

Effort: 40%

Role: PI

Annual Direct: $243,719.19

Total Annual Cost: $342,729.54

NIH-NCI RO1 (Joyce Slingerland) 1R01CA123415-01A2

Title: “Mechanisms whereby Src activates estrogen stimulated ER proteolysis and ER target.”

Funding Period: 4/1/2009 – 3/31/2014

Effort: 15% Role: Co-PI



NIH -NIGMS RO1 (Amjad Farooq) 1R01GM083897-01

Title: “Structural and Functional Studies of the Novel DBD Domain of MKP5.”

Funding Period: 4/1/2008 – 3/31/2013

Role: Co-PI



16

NIH-NCI T32 (Joyce Slingerland)

Title: “Training in Translational Breast Cancer Research”

Funding Period: 9/19/2007 – 8/31/2013 NCE

Role: Mentor



Pending

NIH RO1

Title: “Role of WWOX and Chemical Environmental Factors in Estrogen Receptor Signaling”

Proposed Funding Period: 4/1/2014 – 3/31/2019

Percentile:

Role: Co-PI with Dr. Rami Aqeilan from Ohio State University

Total Direct: $250,000

Research Completed

Bankhead-Coley Pre-SPORE (Joyce Slingerland)

Title: “Role of E6-Associated Protein, E6-AP in the regulation of estrogen receptor turnover and

functions”

Funding Period: 7/1/2009 – 6/30/2011

Effort: 10%

Role: Project Leader



NIH-NIDDK RO1 ARRA

Title: “Roles of Novel Protein Complexes in Estrogen and Progesterone Receptor Signaling “

Funding Period: 2/5/2010 – 12/31/2010

Effort: 40%

Role: PI



DOD (Sivapriya Ramamoorthy)

Title: “Role of the PY motif containing protein, WBP-2 in ER, PR signaling and breast tumorigenesis.”

Funding Period: 12/1/2005-6/30/2009

Role: Mentor (Z. Nawaz)

Annual Direct Cost: $27,778


NIH - R01 (Baxter, Timothy)

Title: MMP-2 Regulation in Aortic Aneurysm

Funding Period: 01/01/05-12/31/2010

Effort: 5%

Role: Collaborator



NIH/NIDDK/NCI - R01 Title: “Role of E6-AP in the Development of Prostate Cancer.”

Funding Period: 09/30/01-08/31/2006

Effort: 35%

17

Role: PI (Z. Nawaz)


Total Cost: $878,632

NIH -R01 Title: “Nuclear Hormone Action: Role of Ubiquitin Pathways”.

Funding Period: 02/01/00-06/30/2006

Effort: 40%

Role: Principal Investigator



NIH (Wheeloch and J. Margaret)

Nebraska Center for Cellular Signaling

Funding Period: 2003-2004

Effort: 10%

Role on project: Mentor

Direct Cost: $11,500

Total Amount: $16,387

DOD (Gao Xiuhua)

(Breast Cancer Research Grant, DAMD17-02-1-0281)

Title: Involvement of steroid receptor coactivator/ubiquitin pathway enzymes in mammary gland

tumorigenesis.

Funding Period: 5/13/02-05/12/04

Role: Mentor



DOD

(Breast Cancer Research Grant, DAMD17-00-1-0142)

Title: Ubiquitin pathway enzymes: Coactivator of nuclear hormone receptors and their role in the

development of breast cancer


Effort: 15%




DOD

(Breast Cancer Research Grant, DAMD17-99-9075)

Title: Role of nuclear hormone receptor coactivator, E6-associated protein (E6-AP) in the development

of breast cancer


Effort: 20%




18

Editorial Responsibilities

Ad-hoc Reviewer

1. Molecular Endocrinology (1999-Present)

2. Endocrinology (2000-Present)

3. Cancer Research (2004-Present)

4. Molecular and Cellular Biology (2002-Present)

5. Molecular Cell (2006-2008)

6. PNAS (2002-Present)

7. Oncology (2005-Present)

8. Journal of Biological Chemistry (2002-Present)

9. NURSA (2007-Present)

10. J. of Molecular Endocrinology (2006-2009)

11. Molecular Pharmacology (2009-Present)

Editorial Board

1. Journal of Carcinogenesis

2. Frontiers in Cancer Endocrinology (2013-Present)

Professional and Honorary Organizations

The Endocrine Society (1999-Present)

American Society of Microbiology (1994-1995)

The American Cancer Society (2005-Present)

American Association for the Advancement of Science (2002-Present)

Phi Beta Delta Honor Society (1988-1990)

Tri Beta Biological Honor Society (1989-1991)

Phi Kappa Phi Honor Society (1988-1992)

Honor Society of International Scholars (1990-1992)

Who’s Who (1995)

Honors and Awards

Scholarship awarded by US Academy for Educational Development, 1987-1991.

Competitive Botany Research Award, University of North Texas, 1991-1992.

Ronald K. Harmon Dissertation Award for Research Achievement in the Applied Life Sciences,

University of North Texas, 1992.

Davenport/Flaming Award, Texas Medical Center, 1998.

Travel Award from Endocrine Society, 1999.

Distinguish Alumni Award from University of North Texas, 2000.

Post- Doctoral Fellowship

December 1992- April 1995: Post Doctoral Fellow

Cell Biology, Baylor College of Medicine, Houston, TX, USA

Area of Research: To unravel the Molecular Mechanism of Action of

Nuclear Hormone Receptors with Specific Emphasis on

Estrogen and Progesterone Receptors, Coactivators and Corepressors and

to study the role of the ubiquitin-proteasome pathway in steroid hormone

receptor functions

19

Other Professional Activities

Clinical Trials

SCCC 2009029: 2012. A Phase II Clinical Trial of BORTEZOMIB (Velcade) in combination with

Tamoxifen in the treatment of patients with metastatic triple negative breast cancer previously

treated with chemotherapy. [PI: Stephan Glück; Co-PI: Zafar Nawaz]

Poster presentations

1. Buffa L. and Nawaz Z. 2012. Molecular mechanism of WBP-2 coactivation function in Estrogen

Receptor transactivation. AACR annual Meeting. Chicago, IL.

2. El Hokayem J. and Nawaz Z. 2011. The Angelman Syndrome protein E6AP transcriptionally

regulates the expression of the retinoic acid metabolizing enzyme CYP26B1 through Estrogen

Receptor Signaling. Keystone Symposia: Environmental Epigenomics. Asheville, NC.

3. Catoe H.W. and Nawaz Z. 2010. E6-AP Facilitates p300 Recruitment to an Estrogen Responsive

Promoter To Allow Efficient Transcription. Endocrine Society Annual Meeting. San Diego, CA.

4. Srinivasan S., Pedroso I.M. and Nawaz Z. 2009. Role of E6-AP in Estrogen Dependent

Transcriptome of MCF-7 Breast Cancer Cells. Endocrine Society Annual Meeting. Washington,

DC.

5. Catoe H. and Nawaz Z. 2009. The Role of E6-Associated Protein in Estrogen Receptor Alpha

Protein Regulation. University of Miami’s 2009 Department of Biochemistry and Molecular

Biology Retreat. Miami, FL.

6. Pedroso I.M. and Nawaz Z. 2009. Effects of E6-AP and Hormone Induction on miRNA Expression

Levels in MCF7 Cells. 2009 Annual Sylvester Cancer Research Poster Session. Miami, FL.

7. Srinivasan S., Ismail A., Pedroso I.M., Rudd K.E., Zhou J. and Nawaz Z. 2009. Genome Wide

Analysis of Estrogen Dependent E6-AP Binding Sites in MCF-7 Breast Cancer Cells. Miami

Winter Symposium. Miami, FL.

8. Dhananjayan S., Ramoorthy S. and Nawaz Z. 2008. WWOX, a Tumor Suppressor Negatively

Regulates the Coactivation Functions of WBP-2 and Oncoprotein YAP. Cold Spring Harbor Lab,

NY.

9. Ramamoorthy S., Dhananjayan S. and Nawaz Z. 2008. E6-Associated Protein (E6-AP) Regulates

Mammary Gland Morphogenesis by Modulating the Ubiquitin-Mediated Proteolysis of the

Progesterone Receptor. Cold Spring Harbor Lab, NY.

10. Dhananjayan S., Ramamoorthy S. and Nawaz Z. 2008. WWOX, a Tumor Suppressor Negatively

Regulates the Coactivation Functions of WBP-2 and Oncoprotein YAP. DOD – Era of Hope

Meeting.

11. Srinivasan S., Ismail I., Rudd K.E., Zhou J. and Nawaz Z. 2008. Genome Wide Analysis of

Estrogen DependentE6-AP Binding Sites in MCF-7 Breast Cancer Cells. Endocrine Annual

Meeting.

20

12. Zafar S., Srinivasan S. and Nawaz Z. 2007. E6-associated protein (E6-AP): A potential tumor

suppressor protein. AACR Annual Meeting.

13. Dhananjayan S., Ramamoorthy S. and Nawaz Z. 2007. Oncogenic WW-domain containing

oxidoreductase negatively regulates the coactivation functions of WW-domain binding protein-2

and yes-associated protein 1. Endocrine Society Annual Meeting.

14. Ramamoorthy S., Dhananjayan S., Zafar S. and Nawaz Z. 2007. E6-Associated Protein is a Cell

Growth Regulator in Mammary gland. Endocrine Society Annual Meeting.

15. Srinivasan S., Zafar S., Nawaz Z. and Loggie B.W. 2006. Transcriptional Regulation of MUC2 by

Estrogen. ASCO GI Annual Meeting.

16. Dhananjayan S., Khan O.Y. and Nawaz Z. 2005. Identification and characterization of WW-

domain binding proteins as E6-AP interacting proteins and their role in steroid hormone receptor

functions. The Endocrine Society Annual Meeting.

17. Srinivasan S., Khan O.Y., Fu G., Ismail A., Tu Y., Lu S. and Nawaz Z. 2005. Multifunction steroid

receptor coactivator, E6-associated protein, E6-AP is involved in development of the prostate

gland. The Endocrine Society Annual Meeting.

18. Verma S., Ismail A., Li X., O’Malley B.W. and Nawaz Z. 2004. Ubiquitin-Conjugating Enzyme,

UBCH7 modulates steroid hormone receptor function by forming a multiprotein complex with

SRC-1 and E6-AP. Key Stone Symposia on Nuclear hormone receptors.



20. Loggie B.W., Nawaz Z., Gatalica Z., Silvaand E. and El-Ella G.A. 2003. Inhibition of

Mucin 2 production: Implications for treatment of Pseudomyxoma Peritonei. The Surgical

Society of Oncology.

21. El Ella G.A., Gatalica Z. and Nawaz Z. 2003. Inhibition of Mucin production: Implications for

treatment of breast cancer. AACR Meeting.



23. Loggie B.W., El-Ella G.A., Gatalica Z., Silvaand E. and Nawaz Z. 2003. Promising new

strategies for treatment of Pseudomyxoma Peritonei. The Surgical Society of Oncology.

24. Haq R.U. and Nawaz Z. 2002. Identification and characterization of WW-domain binding proteins

as E6-AP interacting proteins and their role in steroid hormone receptor functions. The Endocrine

Society.

25. Gao X., Mohsin S.K., Wheeler T.M., Yan F. and Nawaz Z. 2002. E6-associated protein, E6-AP,

is involved in the tumorigenesis of both mammary gland and prostate gland. The Endocrine

Society.

26. Verma S., Liu Z., Haq R., O’Malley B.W. and Nawaz Z. 2002. UBCH7, an E2 ubiquitin-

comjugating enzyme: Its possible role in the steroid receptor transactivation. The Key Stone

Symposia.

21

27. Hopp T.A., Wang C., Pestell R.G., Nawaz Z., Wang M. and Fuqua S.A.W. 2001. A hypersensitive

mutation of estrogen receptor a occurring in premalignant breast disease influences co-activator

binding, receptor acetylation, and stability. The Endocrine Society.

28. Gao X. and Nawaz Z., 2001. The nuclear hormone receptor coactivator, E6-AP is overexpressed

in human mammary tumors. The Endocrine Society.

29. Hopp T., Allred D.C., Hilsenbeck S., Mohsin S., Nawaz Z., O’Connell P., Pestell R.G. and Fuqua

S.A.W. 2000.

30. Barron N., Nawaz Z., Qin J. and O’Malley B.W. 2000. Effects of the Ccr4/Not complexes on

steroid receptor-dependent transcription. The Endocrine Society.

31. Dennis A., Nawaz Z. and O’Malley B.W. 2000. Characterization of UBA3: A novel type of nuclear

hormone receptor coactivator. The Endocrine Society.

32. Cox G.W., Nawaz Z. and Johnson G.V.W. 2000. Analysis of a unique nuclear transglutaminase

(TGase) substrate expressed in macrophages. American Association of Immunology Meeting.

33. Lonard D. M., Smith C.L., Nawaz Z. and O’Malley B.W. 2000. Ligand-mediated down-regulation

of estrogen receptor-alpha depends upon intact AF-2 coactivator-binding surfaces, The Key Stone

Symposia.

34. Zhao H.H., Heinsohn E.C., Tilson K.S., Yang M.C., Nawaz Z., Herrera R.E., Yee D., Brown P.H.,

Diab S.G., Barr F.G., O’Malley B.W., Fuqua S.A.W. and Osborne K. 1999. FKHR, a novel nuclear

receptor interacting protein that functions as both a coactivator and corepresso. AACR Meeting

(The Steroid Receptor Superfamily)

35. Lonard D. M., Nawaz Z., Smith C. L. and O’Malley B. W. 1999. Involvement of ubiquitin-

proteasome mediated protein degradation in steroid receptor function. AACR Meeting (The Steroid

Receptor Superfamily).

36. Lonard D., Nawaz Z., Smith C. L., Tsai S. Y., Tsai M.-J. and O’Malley B. W. 1998. The ubiquitin-

protein ligase E6-AP, mutated in Angelman syndrome, is a steroid receptor coactivator. The Key

Stone Symposia.

37. Nawaz Z., Lonard D., Smith C. L., Tsai S. Y. , Tsai M.-J. and O’Malley B. W. 1998. The angelman


Key Stone Symposia.

38. Nawaz Z., Tsai M.J. and O’Malley B.W. 1996. Specific mutations in the ligand binding domain

selectively abolish the silencing function of human thyroid receptor ß. The Key Stone Symposia,

USA.

39. Burris T.P., Nawaz Z., Tsai S.Y., Tsai M.J. and O'Malley B.W. 1995. Interaction cloning of a

protein, TRIP, which inhibits transactivation by the thyroid hormone and retinoic acid receptors.

The Endocrine Society, USA.

40. Nawaz Z., Stillman D., Burris T., O'Malley B.W. and Tsai M.J. 1994. The yeast SIN3 gene

negatively regulates the transcriptional activity of the human progesterone receptor and positively

regulates the activities of GAL4 and the HAP1 activator. The Endocrine Society, USA.

22

41. Hyder S.M., Nawaz Z. and Stancel G.M. 1993. A single base change in the flanking sequence of a

cellular oncogene creates an active estrogen response element- A possible mechanism of hormonal

carcinogenesis? The Endocrine Society, USA.

42. Nawaz Z., Tsai M.J., McDonnell D.P. and O'Malley B.W. 1992. A system to identify novel steroid

response elements. ASBMB/Biophysical Society, USA.

43. Nawaz Z., McDonnell D.P. and O'Malley B.W. 1991. A novel system to identify steroid responsive

elements. Eight Workshop on Vitamin D, Paris, France

44. Nawaz Z., Smith D.W., McDonnell D.P. and O'Malley B.W. 1991. Expression of functional

vitamin D3 receptor in E. coli. Eight Workshop on Vitamin D, Paris, France.

Invited Oral Presentations

Nawaz, Z. 2014. New Trends in Biomedical Research Workshop. Six lectures: Mechanisms of

Bacterial Pathogenesis and Venues for Novel Therapeutics; Steroid Hormone Receptor Signaling in

Cancer and Neurological Diseases; Targeted Molecular Imaging and Drug Delivery Systems; Targeting

Cancer Stem Cells – A New Era in Tumor Therapeutics; Grant Writing; Reading and Writing a

Scientific Paper versus Poster Presentations. Center of Excellence in Molecular Biology, University of

the Punjab. Lahore, Pakistan. Nawaz, Z. 2012. The Transcriptional Coactivation Function of E6-Associated Protein in the Brain:

Novel Insights into the Pathobiology of Debilitating Neurogenetic Diseases. Scripps Florida. Jupiter, Florida, USA.

Nawaz, Z. 2010. Steroid Hormone Receptor Coactivator, E6-Associted Protein (E6-AP) Regulates

PI3K-Akt Signaling and Cell Growth. FASEB: The Physiology of Integrated Nuclear and Extranuclear Steroid Signaling, Snowmass Village, Colorado, USA.

Nawaz, Z. 2009. Tumor suppressor, WWOX1, attenuates oncogenic YAP1 and WBP-2 mediated ER

and PR transactivation functions. The HIPPO Tumor Suppressor Pathway: A Brainstorming Workshop. Rome, Italy

Nawaz, Z. 2009. E6-AP Mediated Proteolysis of PR-B Regulates Mammary Gland Tumorigenesis by

Modulating the Wnt Signaling Pathway. Endocrine Society Annual Meeting, Washington, D.C. Nawaz, Z. 2008. Regulation of Estrogen and Progesterone Receptor Coactivators by a Novel

Tumor Suppressor. University of South Florida. Tampa, Florida. Nawaz, Z. 2008. Bench to Bed: Molecular Strategies for Targeted Cancer Therapies. International Symosium on Applications of Molecular Biological Research in Health, University of Punjab, Lahore, Pakistan. Nawaz, Z. 2008. Mechanism of action of siRNAs – An Overview. International Symosium on Applications of Molecular Biological Research in Health, University of Punjab, Lahore, Pakistan. Nawaz, Z. 2007. Steroid Hormone Receptor Coactivator, E6-Associated Protein (E6-AP) Regulates PI3K-Akt Signaling and Prostate Cell Growth. AACR Annual Meeting, Los Angeles, California. Nawaz, Z. 2006. Estrogen receptor degradation: Implications in breast cancer treatment. Eli Lilly Pharmaceuticals.

23

Nawaz, Z. 2006. Determinants of estrogen receptor stability. University of Missouri, Columbia, Missouri. Nawaz, Z. 2006. Ubiquitin-proteasome pathway and gene transcription. The Pennington Biomedical Research Center, Baton Rouge, Louisiana. Nawaz, Z. 2006. Role of E6-AP in the development of prostate gland. Creighton University, Omaha, Nebraska. Nawaz, Z. 2006. Steroid hormone receptor coactivator, E6-associated protein (E6-AP) regulates P13K-Akt signaling and prostate cell growth. Baylor College of Medicine, Houston, Texas. Nawaz, Z. 2006. Novel roles of steroid receptor coactivator E6-associated protein (E6-AP) in cellular signaling. Baylor College of Medicine, Houston, Texas. Nawaz, Z. 2005. Ubiquitin-proteasome pathway enzymes police the estrogen receptor alpha-mediated gene activation. Louisiana State University. Baton Rouge, Louisiana. Nawaz, Z. 2005. Molecular determinants of estrogen receptor stability and transactivation. Pakistan. Nawaz, Z. 2005. Role of multifunction steroid receptor coactivator, E6-associated protein (E6-AP) in prostate gland development. Pakistan. Nawaz, Z. 2005. Role of multifunction steroid receptor coactivator, E6-associated protein (E6-AP) in prostate gland development. China. Nawaz, Z. 2005. Role of multifunction steroid receptor coactivator, E6-associated protein (E6-AP) in prostate gland and mammary gland development. China. Nawaz, Z. 2004. Ubiquitin-Proteasome Pathway Enzymes act as Modulators of Steroid Hormone Receptors. Cancer Center, Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama. Nawaz, Z. 2004. Ubiquitin-Conjugating Enzyme, UBCH7 modulates steroid hormone receptor function by forming a multiprotein complex with SRC-1 and E6-AP. MD Anderson. Houston, Texas. Nawaz, Z. 2003. Novel modulators of steroid hormone receptors. Biomedical Sciences. Creighton University, Omaha, Nebraska. Nawaz, Z. 2003. Ubiquitin Conjugating Enzyme, UBCH7 a coactivator for steroid hormone receptors. Endocrine Meeting. Philadelphia, Pennsylvania. Nawaz, Z. 2003. Role of the ubiquitin-proteasome pathway in nuclear hormone receptor functions. NIH. USA. Nawaz, Z. 2003. Novel coactivators of steroid hormone receotprs. IBC meeting on Nuclear Receptors as Targets for Drug Development, Philadelphia, Pennsylvania. Nawaz, Z. 2003. Steroid hormone receptor cactivators and gene transcription. Center for Advanced Molecular Biology. Lahore, Pakistan. Nawaz, Z. 2002. Steroid hormone receptor cactivators. Cancer Center, Creighton University. Omaha, Nebraska.

24

Nawaz, Z. 2002. Steroid hormone receptor coregulators. Department of Pharmacology. Texas Tech University, Amarillo, Texas. Nawaz, Z. 2002. E6-Associated Protein (E6-AP) and Steroid Hormone Receptor Functions. Department of Pharmacology and Cell Biophysics. University of Cincinnati Medical School. Cincinnati, Ohio. Nawaz, Z. 2000. Regulation of Gene Expression by the Nuclear Hormone Receptor-Coactivator

Complex Requires the Ubiquitin-Proteasome Pathway. The Endocrine Society. Nawaz, Z. 2000. The Angelman syndrome-associated gene, E6-AP, is a coactivator for nuclear

hormone receptor superfamily. University of North Texas. Denton, Texas.

Nawaz, Z. 1999. Impact of the ubiquitin-proteasome pathway on nuclear hormone action. Tumor

Biology Section, University of Texas, M.D. Anderson Cancer Center. Houston, Texas.

Nawaz, Z. 1999. Proteasome-dependent degradation of the human estrogen receptor. The Endocrine

Society Meeting. San Diego, California.

Nawaz, Z. 1998. The angelman syndrome-associated gene, E6-AP, is a coactivator for nuclear

hormone receptor superfamily. University of Oklahoma Health Science Center. Oklahoma City,

Oklahoma.

Nawaz, Z. 1998. The Angelman syndrome-associated gene, E6-AP, is a coactivator for nuclear

hormone receptor superfamily. The Endocrine Society Meeting. New Orleans, Louisiana.

Nawaz, Z. 1997. The Angelman syndrome-associated gene, E6-AP, is a coactivator for nuclear

hormone receptor superfamily. Baylor College of Medicine. Houston, Texas.

Nawaz, Z. 1997. A novel host system to study steroid hormone receptor action. Nuclear Institute of

Biotechnology and Genetic Engineering (NIBGE). Faisalabad, Pakistan

Nawaz, Z. 1997. A novel host system to study steroid hormone receptor action. National Institute of

Biotechnology and Genetic Engineering. Faisalabad, Pakistan.

Nawaz, Z. 1996. Mechanism of gene silencing by thyroid hormone receptor. University of Texas

Health Science Center at San Antonio. San Antonio, Texas.

Nawaz, Z. 1995. Molecular mechanism of gene silencing by thyroid hormone receptor. Baylor College

of Medicine. Houston, Texas.

Nawaz, Z. 1995. Molecular mechanism of action of steroid hormone receptors. University of North

Texas. Denton, Texas.

Nawaz, Z. 1994. The yeast SIN3 gene negatively regulates the transcriptional activity of the human

progesterone receptor and positively regulates the activities of GAL4 and the HAP1 activator. Proc.

76th Ann Mtg Endocrine Soc. Anaheim, California.

Nawaz, Z. 1993. Cloning of steroid hormone receptors in yeast (Saccharomyces cerevisiae). University

of North Texas. Denton, Texas.

25

Patents Applied

1. Use of “Pure” Antiestrogen Synthetic Steroids to Inhibit Progestin-Induced Transcription and

Method for Administrating Same to Humans and Animals; No. 60/090,074; G&S No. 25630/04

(2004)

2. Novel Coactivator Overexpressed in Endocrine Tumors; OTA# 98-83; P-01750 (2002)

3. Production of antibodies against a novel coactivator, E6-associated protein (E6-AP). (2001)

4. siRNAs mediated reduction of expression of mucin proteins in neoplasms. (2003)

5. Development of New Therapeutic Agents for the Treatment of Breast Cancer. (2003)

Courses and Workshops Attended

Thirteenth Annual Molecular Endocrine Workshop, USA (1999)

Eight Workshop on Vitamin D, Paris, France (1991)

The ASBMB/Biophysical Society Workshop, USA (1992)

The Forty-sixth Annual Symposium on Fundamental Cancer Research, USA (1998)

The Welch Foundation Conference on Chemical research, USA (1990)

The Endocrine Society Annual Meeting, USA (1993-Present)

The Key Stone Symposium, USA (1998-Present)

Study Sections

1. Department of Veterans Affairs (1999-2002)

2. PA DOH CURE Program (2000-2009)

3. US Army Prostate Cancer Research Program (2001-2002)

4. US Army Breast Cancer Research Program (2002-2009)

5. NIH (2006)

6. Texas A&M University, Center for Environmental and Rural Health, Pilot Project Grant

Application (2006)

7. University of Missouri Seed Grants (2007)

8. NIH Molecular and Cellular Endocrinology [MCE] (2010)

9. US Army Prostate Cancer Research Program [USAMRMC/CDMRP] (2010-Present)

10. DoD/CDMRP Breast Cancer Research Program Idea Award/Chair, Study Section (2012)

VI. TEACHING

BMB Graduate Program Director (2009 – 2012)

Director dual BS/PhD Program (2011-Present)

Mentoring Junior Faculty

o KO1 Awards

Dr. Elizabeth Floyd, PBRC, Louisiana State University

Dr. Prema Rampuri, Creighton University

o Komen Catalyst

Dr. Seema Gupta, Department of Radiation Oncology, University of

Miami/Sylvester Comprehensive Cancer Center

Post Doctoral Fellows

o Mentor/Co-PI on Post Doctoral Fellow UM/SCCC Braman Family Breast Cancer

Institute Training Grant - “Training in Translational Breast Cancer Research”

26

Graduate Teaching

o Regulation of Eukaryotic Gene Transcription – BMB610, Department of

Biochemistry & Molecular Biology, UM Miller School of Medicine

o Advanced Biochemistry & Molecular Biology – BMB609, Department of

Biochemistry & Molecular Biology, UM Miller School of Medicine

o Journal Club – BMB601, Department of Biochemistry & Molecular Biology, UM

Miller School of Medicine

o Scientific Reasoning and Logic in Clinical Cancer Biology – CAB 602, Cancer

Biology, UM Miller School of Medicine/SCCC

o Colloquia in Clinical Cancer Research – CAB 630, Cancer Biology, UM Miller

School of Medicine/SCCC

o Seminar in Cell & Molecular Biology – 242-466

o Readings – 242-548

Medical School Teaching

o MBL Module

Carbohydrate Metabolism (11 lectures per year)

Energy and Carbohydrate Metabolism and Their Regulation 1

Essential Requirements for Metabolism/Factors that Regulate

Metabolism

Digestion and Absorption of Carbohydrates and Proteins

Glycolysis

Pentose Phosphate Pathway/Pyruvate Dehydrogenase Complex

Citric Acid Cycle/Electron Transport Chain

Ketosis, Roles of Other Carbohydrates

Glycogenesis/Glycogenolysis/Glycogen Storage Disease

Glucose/Membrane Transport/Signal Transduction

Glucose Homeostasis Introduction/Gluconeogenesis

Integration of Metabolism

Undergraduate and Summer Students

Past

o Naomi Desrosiers (Summer 2012)

o Raj Parikh (Summer 2012)

o Rhiya Mittal (Summer 2012)

o Alexander Garcia (Fall 2011)

o Michelot Michel (Summer 2011)

o Obianuju Akaniru (Summer 2011)

o Jean-Pierre Obeid (Summer 2011)

o Jude Chan (Summer 2011)

o Ilona Juan (Summer 2009)

o Shannon Hahn (Summer 2008)

o Courtney Griffiths (Spring/Summer 2008)

o Ali Abbas (Spring 2008)

o Najia Hamid (Summer/Fall 2007)

o Mahera Anjum (Summer 2007)

o Nitin Aggarwal (Spring 2007)

27

o Monica Gonzalez (Fall 2006)

o Sumit Jain (Fall 2006)

o Leticia A. Polite (Summer 2006)

o Adante Hart (Summer 2006)

Current Medical Students

Jennifer McLeod (2012)

Current Graduate Students

Celeste Amadei (2015)

Kelsey Moody (2014)

Current Postdoctoral Fellows

Jimmy El Hokayem (2013)

Laura Buffa (2010)

Rozina Tufail (2008)

Ph.D. Thesis Advisor

Patricia Boothe (2010)

Heath Catoe (2006-2010)

Sivapriya Ramamoorthy (2004-2009)

Sathish Srinivasan (2004-2009)

Sarath Dhananjayan (2003-2007)

Andrew Dennis (1999-2004)

Virginia Pearce (1997-2002)

Ph.D. Thesis Committees

Ankita Thakkar (2013-Present)

Ashley Melchior (2011-2012)

Amy Plotkin (2010-2014)

Cale Fahrenholtz (2010-2014)

Nirav Patel (2010-2014)

Wensi Tao (2010-Present)

Ali Saeed (2009-2011)

Jimmy El Hokayem (2009-2013)

Diana Azzam (2009-2012)

Fangfang Lai (2009-2012)

Melvys Valledor Ceballos (2009-2011)

Salil Sharma (2008-2011)

Jeffim Kuznetsov (2008-2012)

Qiuping Ma (2008 External Comm. Chair)

Kevin Curtis (2007-2010)

Megan Rieger (2007-2010)

Kenneth Seldeen (2007-2009)

Iliana Soto (2007-2011)

28

Sophia Kyriacou (2006-2008)

Heath Catoe (2006-2010)

Shuyun Rao (2005-2009)

Names of

Mentor &

Trainees

(include training

level)

Training

Period Degree(s) Prior to Entering Training

Title of Research Project

While Training with this Mentor

Type(s)

Award

Date(s)

Awarding

Institution

Z. Nawaz /

Kibeom Jang

(pre)

2012 - 2013 MS 2010

Hanyang

University, S.

Korea

Mechanisms whereby Src activates

estrogen stimulated ER proteolysis

and ER target gene expression

Z. Nawaz /

Patricia Boothe

(pre)

2010

MUC4, the Integral Membrane

Modulator of ERBB2: The Effects

of MUC4 Expression on ERBB2 &

ERBB3 Phosphorylation, Receptor

Levels and Sub-Cellular

Localization in Breast Cancer Cells

Treated with Neuregulin

Z. Nawaz /

Jimmy El

Hokayem

(pre)

2009 -

2013 M.S. 8/2007

American

University of

Beirut

Role of the Coactivation Function

of E6AP and ER in Angelman

Syndrome Pathogenesis

Z. Nawaz /

Ali Saeed

(pre)

2009 -

2011 B.S. 5/2005

University of

Miami,

Florida

The Role of WBP1 in Steroid

Hormone Receptor Regulation

Z. Nawaz /

Heath Catoe

(pre)

2006 -

2010 B.S. 5/2004

University of

South Carolina,

Columbia

Role of E6-AP in Estrogen Receptor

Alpha Functional Modulation

Z. Nawaz /

Sivapriya

Ramamoorthy

(pre)

2004 -

2009 M.S. 8/2001

Bharathidasam

University

Role of E6-AP in Mammary

Gland Development and Breast

Carcinogenesis

Z. Nawaz /

Sathish

Srinivasan

(pre)

2004 -

2009 M.S. 8/2001

Birla Institute of

Technology and

Science

Role of E6-AP in Prostate Gland

Development and Carcinogenesis

Z. Nawaz /

Sarath

Dhananjayan

(pre)

2003 -

2007 M.S. 8/2001

Bharathidasam

University

Role of WBP-2 in Steroid Hormone

Receptor Function and Breast

Carcinogenesis

Z. Nawaz /

Andrew Dennis

(pre)

1999 -

2004 Ph.D. 12/2004

Baylor College

of Medicine

Function of Protein Degradation

by 26S Proteasome During

Progesterone Receptor

Dependent Transcription

29

Z. Nawaz /

Virginia Pearce

(pre)

1997 -

2002 Ph.D. 6/1997

University of

North Texas

Isolation and Characterization of

New Phytoestrogen(s) That

Modulate Human Estrogen

Receptor Activity

Z. Nawaz /

Jimmy El

Hokayem

(post)

2013 -

Present Ph.D. 4/2013

University of

Miami

“E6-AP transcriptional targets in the

pathogenesis and therapy of AS”

Z. Nawaz /

Laura Buffa

(post)

2010 -

Present Ph.D. 2/2007

IMPRS,

Dresden,

Germany

Role of E6-Associated Protein, E6-

AP in the regulation of estrogen

receptor turnover and functions

Z. Nawaz /

Kosalai

Kaliappan

(post)

2009 -

2012 Ph.D. 2009

ICGEB, New

Delhi, INDIA

Mechanisms whereby Src activates

estrogen stimulated ER proteolysis

and ER target

Z. Nawaz /

Rozina Tufail

(post)

2008 -

Present Ph.D. 2003

University of

Punjab

Pakistan

Genome Wide Analysis of

Estrogen-Dependent E6-Associated

Protein Binding Sites in MCF-7

Breast Cancer Cells

Z. Nawaz /

Sathish

Srinivasan

(post)

2009 -

2010 Ph.D. 11/2009

University of

Miami

Roles of Novel Protein Complexes

in Estrogen and Progesterone

Receptor Signaling

Z. Nawaz /

Ilene Pedroso

(post)

2008 -

2009 Ph.D. 2007

University of

Miami

Role of E6-associated protein in the

Development of Tamoxifen

Resistant Breast Cancer

Z. Nawaz /

Sarath

Dhananjayan

(post)

2008 -

2009 Ph.D. 2007

University of

Miami

Role of WBP-2 in Steroid Hormone

Receptor Function and Breast

Carcinogenesis

Z. Nawaz /

Ayesha Ismail

(post)

2003 -

2007 Ph.D. 12/1999

National

Institute of

Nutrition, India

Role of the Ubiquitin-Proteasome

Pathway in Breast Carcinogenesis

Z. Nawaz /

Guilian Fu

(post)

2003 -

2007 M.D. 8/1980

Julin Medical

College


Development and Carcinogenesis

Z. Nawaz /

Obaid Y. Khan

(post)

2002 -

2004 Ph.D. 5/1998

University of

Glasgow


Development

Z. Nawaz /

Seema Verma

(post)

2001 -

2003 Ph.D. 2000

University of

Punjab

Characterization of UbcH7 as a

Coactivator for Steroid

Hormone Receptors.

Z. Nawaz /

Minawar Sattar

(post)

2001 -

2002 Ph.D. 12/2000 Texas A&M

Role of E6-AP in the Development

of Normal Prostate Gland and

Prostate Gland Cancer

30

Z. Nawaz /

Riaz-ul-Haq

(post)

2000 -

2002 Ph.D. 1996

University of

Punjab

Role of the Ubiquitin-Proteasome

Pathway in Nuclear Hormone

Receptor Function

Z. Nawaz /

Xiuhual Gao

(post)

1999 -

2004 Ph.D. 9/1993

Torai

University,

Japan

Role of E6-AP in Breast

Carcinogenesis

VII. SERVICE:

Committees and Administrative Responsibilities:

Administrative:

BMB Graduate Program Director, 2009-2012

Director Dual BS/PhD Program, 2011-2012 (Developed and received the approval of the program)

Associate Research Director of the Braman Family Breast Cancer Institute/ SCCC, Miami, Florida,

2004-Present.

Committees:

CAB Steering Committee, 2008-Present

Member of PIBS Curriculum Committee for the Umbrella Program, University of Miami, 2008-

2012

UM/Sylvester Lymphoma Research Career Development Grant Reviewer, 2008.

Member of IBS Curriculum Committee, University of Miami, 2007-Present.

UM/Sylvester Pap Corps Developmental Cancer Research Grant Reviewer, 2007-Present.

Member ACS Institutional Grant Review Committee, University of Miami School of Medicine,

2006-Present.

Braman Developmental Grants Program Director, 2005-Present

Member SCCC Scientific Steering Committee, University of Miami School of Medicine, 2005-

Present.

Member SAC Committee, University of Miami School of Medicine, 2005-2008.

American Cancer Society Grant Reviewer, 2008.

Member COBRE, Pennington Biomedical Research Center LA, 2006-Present.

NIH Molecular and Cellular Endocrinology [MCE] Grant Reviewer, 2006-2008

NIH Endocrinology, Metabolism, Nutrition and Reproductive Sciences [EMNR] Grant Reviewer,

2006.

DOD Breast Cancer Research Program [BCRP] Grant Reviewer, 2002-2006.

DOD Prostate Cancer Research Program Grant Reviewer, 2002.

New Graduate Degree Programs:

In the process of developing proposals and approval of following new graduate programs:

1. MS Degree Program in Biochemistry and Molecular Biology

2. Executive MS Degree Program in Biochemistry and Molecular Biology

a. Approved and implemented Fall 2013

3. Executive PhD Degree Program in Biochemistry and Molecular Biology

a. Approved and implemented Spring 2014

curriculum vitae updated may 2015phydatabase.med.miami.edu/documents/cv/nawaz.zafar_2739_cv.pdf ·...

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