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CURRICULUM VITAE

A. Personal Details

Full Name SEOW Heng Fong

Title: Professor

Designation

Professor of Molecular Immunology

Research interest: cancer immunology and molecular biology for

cancer diagnostics and therapeutics

Administrative Appointment Deputy Dean, School of Graduate Studies (2010-2013)

Current Address Contact number and email

Immunology Unit,

Department of Pathology,

Faculty of Medicine and Health Sciences,

Universiti Putra Malaysia, Serdang,

Selangor 43400, Malaysia

Tel: 603-8947 2387

Mobile: +6012 248 9396

Fax:603-8946 4232

shf@upm.edu.my

seowhf@gmail.com

B. Academic Qualification

Certificate / Qualification

obtained

Name of School /

Institution

Year

obtained

Area of Specialization

PhD University of Auckland

New Zealand

1986 Biochemistry

BSc (Hons) Chelsea College,

University of London,

United Kingdom

1982 Biomedical Sciences

C. Scientific experience and Specialisation

Organization Position Start

Date

End

Date

Specialisation

Postdoctoral fellow

(Peter Parham’s lab)

Stanford

University,

California, USA

1986 1987 Molecular Cloning and Gene

Sequencing

Institute of Molecular and Cell

Biology, National University

of Singapore

Senior Research

Fellow

1987 1990 Cloning and gene expression

CSIRO Australia Senior Scientist

Project Leader,

Cytokines Group

1990 1995 Cytokines in nfectious

disease and vaccine

development

Macfarlane Burnet Institute Acting Head

Hepatitis Unit

1996 1997 Hepatitis E diagnostics and

vaccine development;

Hepatitis B antivirals

Washington State University,

Pullman, USA

Visiting Scientist May

1993

Sept

1993

Flow cytometry &

Γδ T cell identification

Centenary Institute, University

of Sydney, Australia

Visiting Scientist April

2003

Dec

2003

Genetics, Gene and Stem cell

therapy

Cancer Centre, Prince Alfred

Hospital, South Western

Health, Sydney, Australia

Research

administrator

August

2007

Dec

2007

Cancer

tel:603-8947mailto:shf@upm.edu.mymailto:seowhf@gmail.com

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D. Current research projects

Title of project StartingDate

Influence of cross talk between polarized macrophages and cancer stem-like cells on

tumorigenicity, metastasis and immune responses

March 2015

Effects of exosomes on angiogenesis March 2015

Identification of microRNAs associated with colon cancer metastasis and effects of

antagomirs on colon cancer cell invasion and metastasis in SW480

Sept 2013

Effects of silencing disheveled 1, 2 and 3 on cancer cell invasion, migration and

canonical WNT pathway-mediated TCF-LEF transcriptional activity

Sept 2012

Aberrations in WNT and NOTCH signaling pathways in primary colorectal carcinoma

tissues

Sept 2011

Relationship between M1/M2 macrophages with TGF-β and IL-17 expression in

primary colorectal carcinoma tissues

Sept 2011

E. Honours and Awards Name of awards Title Award Authority Award Type Year

Academic Awards Dean’s Fellowship Stanford

University

University 1986 & 1987

Non-Academic Awards

Fellowship Ministry of

Commerce ,

Australia

National 1993

Awards of Merit

Detection of medically

important Candida

species by semi-nested

PCR

A Molecular

Diagnostic Kit to

Monitor Response to

Standard

Chemotherapy.

Generation of Human

Umbilical Cord derived

Mesenchymal Stem

Cells: A Tool for Stem

Cell Therapy, 2010

Mesenchymal Stem

Cells Mediated Tumour

Cell Suppression: A

Potential Therapy for

Cancer

Generation and

Characterisation of

Mesenchymal stem

Cells Derived from

Myocardiac Tissues: A

potential Pool of

Cardiac Stem Cells

The Effect of Human

Universiti Putra

Malaysia

Universiti Putra

Malaysia

Malaysian

Technology

Expo (MTE)

Universiti Putra

Malaysia

UPM

UPM

Gold Medal,

Pameran Reka

Cipta, PRPI

2012

UPM

Gold Medal,

Pameran Reka

Cipta, PRPI

2010 UPM

SILVER Medal

National

GOLD Medal

Pameran Reka

Cipta, PRPI

2009

GOLD Medal

Pameran Reka

Cipta, PRPI

2009

UPM

SILVER Medal

Pameran Reka

Cipta, PRPI

2009

UPM

17-19 July

2012

20-22 July

2010

4-6 February

2010, Putra

Word Trade

Centre (PWTC)

28 July 2009

28 July 2009

28 July 2009

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Mesenchymal Stem

Cells on the

Proliferation and

Cytotoxicity of Natural

Killer Cells

F. List of publications

Papers relating to work on microRNA and qPCR

Pei Yuan He, Wai Kien Yip, Boon Lee Chai, Boon Yean Chai, Mohd Faisal Jabar , Noraini

Mohd Dusa, Norhafizah Mohtarrudin, Heng Fong Seow. Inhibition of cell migration and

invasion by miR-29a-3p in a colorectal cancer cell line through suppression of CDC42BPA

mRNA expression (manuscript in preparation)

Pei Yuan He, Wai Kien Yip, Mohd Faisal Jabar, Heng Fong Seow. miR-96-5p inhibitor blocks

migration but has no influence on cell invasion in colorectal cancer. (manuscript in preparation)

P.Y. He, W.K. Yip, H.F. Seow. Are miR-29 and miR-96 oncomirs or tumour suppressors?

20th World Congress on Advances in Oncology and 18th International Symposium on Molecular

Medicine, Metropolitan Hotel, Athens, Greece, October 8-10, 2015, A283.

Ng CT, Yip WK, Seow HF. Inhibition of MEK-ERK and PI3K-Akt pathways differentially

affects angiogenesis and microRNA expression. RNAi 2014: Short and long noncoding RNAs, 9

th International Conference RNAi 2014, 25-27 Mac 2014 , St Hilda’s College, Oxford, United

Kingdom. http://libpubmedia.co.uk/rnai-2014/speakers-agenda/

Other publications:

Seow HF, Yip WK, Fifis T. Advances in targeted and immunobased therapy for colorectal cancer.

OncoTargets and Therapy 2016, 9:2565-2574.

Yip WK, He PY, M Abullah, Yusof, Seow HF. Increased expression of phosphatidylinositol 3-kinase

p110α and gene amplification of PIK3CA in nasopharyngeal carcinoma. Path Oncol Res (2016), 2(2):413-

419.

Peyman Amini , Maha Abdullah, Lee Sing Seng, Thanusha Karunakaran, Norzhafarina Hani, Saraiza Abu

Bakar, Amir Hamzah Abdul Latiff, Seow Heng Fong and Yap Yoke Yeow. Ethnicity influences disease

characteristics and symptom severity in allergic rhinitis patients in Malaysia. International Forum of

Allergy & Rhinology. (2016) DOI: 10.1002/alr.21442.

Ayunidra, Yip WK, Seow HF. Combinatorial Treatments Targeting IGF-1R, PI3K, mTOR, or MEK

Signaling Pathways Synergize to Inhibit Cell Growth, Induce Apoptosis, and Arrest Cell at G1 Phase in

MDA-MB-231 cell line. Biomedicine and Pharmacotherapy (2015), 75, 40-50.

Ng CT, Yip WK, Seow HF. Comparison of endothelial cell invasion by SV40 large antigen and

telomerase- immortalized human microvascular endothelial cell lines in response to VEGF and bFGF in a

three-dimensional (3D) cell culture system. Malaysian J Path (2015) 37(3): 219 – 225.

Goh IWL, Yip WK, Seow HF. Characterization of tumorspheres generated from nasopharyngeal

carcinoma cell line, TW06 and chemoresistance to docetaxel and oxaliplatin. Malaysian J Med Health Sc

(2015) 11 (2): 9-20.

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SY Chew, YK Cheah, HF Seow, D Sandai, LTL Than. In vitro modulation of probiotic bacteria on the

biofilm of Candida glabrata. Anaerobe 34, 132-138.

SY Chew, YK Cheah, HF Seow, D Sandai, LTL Than. Probiotic Lactobacillus rhamnosus GR‐1 and Lactobacillus reuteri RC‐14 exhibit strong antifungal effects against vulvovaginal candidiasis‐causing Candida glabrata isolates. Journal of applied microbiology 118 (5), 1180-1190.

Koh RY, Lim CL, Ho CC, Uhal BD, Maha A, Vidyadaran S, Heng Fong Seow Inhibition of

transforming growth factor-β receptor via the activin 5 receptor- like kinase-5 inhibitor attenuates

pulmonary fibrosis. Molecular Medicine Reports (2015) 11: 3808-3813.

Than L, KP Ng, Chong PP, Seow HF. Detection of medically important Candida species by absolute real

time quantitative PCR. Jundisphapur J Med Microbiol (2015), 8 (1):e14940.

Kasi R, Koh RY, Lim CL, Yip YK, Seow HF and MM Ching. para-Phenylenediamine-induces apoptosis

via a pathway dependent on PTK-Ras-Raf-JNK activation but independent on PI3K/Akt pathway in

NRK-52E cells. Molecular Medicine Reports (2015), 11: 2262-2268.

Ooi SC, Ho CC, Seow HF. Isolation of a potential anticancer agent with protein phosphatase inhibitory

activity from soil-derived Penicillium sp. strain H9318. J Trop Pharm Res (2015), in press.

Koh RY, Lim CL, Ho CC, Uhal BD, Maha A, Vidyadaran S, Seow HF. Metabolites from

Actinomyces strain H6552 extract inhibit transforming growth factor-mediated pulmonary fibrosis. J Trop

Pharm Res (2014)13 (11):1815-1823.

Seow HF. Tumour immunology. Malaysian J Pathol 2014; 36(3) :226

Yip WK, Choo W, Leong PP, Leong V, Jabar F, Seow HF. (2013) Molecular alterations of Ras Raf

mitogen-activated protein kinase and phosphatidylinositol 3 kinase Akt signaling pathways in colorectal

carcinoma from a tertiary hospital in Kuala Lumpur Malaysia. Acta Pathologica Microbiologica e

Immunologica Scandinavica (APMIS),121: 954–966, IF 2.068, (Q1 Pathology)

Davoodi H, Hasemi SR, Seow HF. 5-Fluorouracil induce the expression of TLR4 on HCT116 colorectal

cancer cell line expressing different variants of TLR4. Iranian J Pharm Res (2013) 12, 453-460, IF 0.674,

ISSN: 17350328

Chye SM, Tiong YL, Yip WK, Koh RY, Len YW, Seow HF, Ng KY, Ranjit DA, Chen SC., Apoptosis

induced by para-phenylenediamine involves formation of ROS and activation of p38 and JNK in chang

liver cells. Environmental Toxicology (2012) 13, online: 22 NOV 2012. IF: 2.708.ISN 1522-7278

Yip WK and Seow HF. Activation of phosphatidylinositol 3-kinase/Akt signaling by EGF downregulates

membranous E-cadherin and β-catenin and enhances invasion in nasopharyngeal carcinoma cells Cancer

Letters (2012), 318, 115-234.(10 citations in Scopus)

Fonseka M, Ramasamy R, Yip WK, Tan BC and Seow HF. Human Umbilical Cord Blood-Derived

Mesenchymal Stem Cells (hUCB-MSC) Inhibits the Proliferation of K562 (Human Erythromyeloblastoid

Leukemic Cell Line). Internat. Cell Biol. (2012) 36, 793-801

Ramasamy R, Tong CK, Yip WK, Vellasamy S, Tan BC and Seow HF. bFGF modulate growth kinetic

of MSC Basic Fibroblast Growth Factor Modulates the Cell Cycle of Human Umbilical Cord Derived

Mesenchymal Stem Cells (2012) Cell Proliferation, 45, 132-139.

Than, L, Chong PP, Ng KP and Seow HF. Application of seminested PCR method for detection of ten

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medically important Candida species. Diagnostic Microbiology and Infection (2012) 72 (2) , pp. 196-198.

Yong, P.V.C., Seow, H.F., Rosli, R., Sidik, S.M., Chong, P.P. (2012). Histopathological Characteristics of

Experimental Candida tropicalis Induced Acute Systemic Candidiasis in BALB/c Mice. International

Journal of Zoological Research. (ePUB)

Davoodi H and Seow HF. (2011) Variant Toll-Like Receptor4 (Asp299Gly and Thr399Ile Alleles) and

Toll-Like Receptor2 (Arg753Gln and Arg677Trp Alleles) in Colorectal Cancer. Iran J Allergy Asthma

Immunol. 10(2): 91-99. (16 citations in Scopus)

Cheenpracha, S, Borris RP, Tran TT, Jee JM, Seow, HF, Cheah HY Ho CC and Chang LC. 2. Three

New Amides from Streptomyces sp. H7372 J. Braz. Chem. Soc., 2011, vol.22, n.2, pp. 223-229

Leong PP, Rohaizak M, Naqiyah, Cheong SK and Seow HF. (2011) HLA-A and breast cancer in West

Peninsular Malaysia. Medical Oncology 28, (1): 51-56

Seow HF. Molecular diagnostics for tumour genotyping in selecting cancer targeted therapies. Malaysian

Society of Genetics Jan-July 2011, 7-9.

Lim CSY, Rozita R, Seow HF, Chong PP. Candida and invasive candidiasis: back to basics. European

Journal of Clinical Microbiology, 2011, 1-11.

Tong CK, Vellasamy S, Tan BC, Abdullah M, Vidyadaran S, Seow HF and Ramasamy R. Generation

of mesenchymal stem cell from human umbilical cord tissue using a combination enzymatic and

mechanical disassociation method. Cell Biology International (2011) 35, 221–226

Abdullah M, Chai PS, Loh C-Y , Chong MY, Quay HW, Vidyadaran S, Seman Z, Kandiah M, Seow,

HF. Carica papaya increases regulatory T cells and reduces IFN- +CD4+ T cells in healthy human

subjects. Molecular Nutrition & Food Research 2011, 55 (5) , pp. 803-806

Lim CSY, Rozita R Seow HF, Chong PP. Transcriptome profiling of endothelial cells during

infections with high and low densities of C. albicans cells. International Journal of Medical

Microbiology, 2011 (online March) 301 (6) , pp. 536-546

1. Cheenpracha, S, Borris RP, Tran TT, Jee JM, Seow, HF, Cheah HY Ho CC and Chang LC. 2. Three New Amides from Streptomyces sp. H7372 J. Braz. Chem. Soc., 2011, vol.22, n.2, pp. 223-229

2. 3. Seow, H.F., Yip W.K,. Loh H.W., Ithnin H., Por P. and Rohaizak M. Immunohistochemical Detection of

Phospho-Akt, Phospho-BAD, HER2 and Oestrogen Receptors alpha and beta in Malaysian Breast Cancer

Patients. Pathology Oncology Research 2010, 16:239-248.

4. Leong PP, Rohaizak M, Naqiyah, Cheong SK and Seow HF. HLA-A and breast cancer in West Peninsular Malaysia. Medical Oncology, published online 13 Jan 2010.

5. Chong, P.P., Yong, P.V.C., Seow, H.F., Rosli, R. (2010). Gene expression profiling of mouse host response to Candida tropicalis infection. International Journal of Infectious Diseases 14 Supplement 1,

e189.

6. Yip WK, Cheenpracha S, Chang LC, Ho CC, Seow HF. 2010. Anti-proliferative and anti-invasive properties of a purified fraction from Streptomyces sp. H7372. Int J Oncol 2010, 37:1229-1241.

7. 8. Cheenpracha S., Zhang H., Mar A.M., Foss A.P., Foo S.H., Lai N.S., Jee J.M., Seow H.F. , Ho C.C. and

Chang L.C. Yeast glycogen synthase kinase-3beta pathway inhibitors from an organic extract of

Streptomyces sp. Journal of Natural Products. 2009; 72(8): 1520-1523

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9. Lim C.S., Wong W.F., Rosli R., Ng K.P., Seow H.F. and Chong P.P. 2-dodecanol (decyl methyl carbinol) inhibits hyphal formation and SIR2 expression in C. albicans. Journal of Basic Microbiology.

2009; 49 (6): 579-583.

10. Yong, P.V.C., Ong, K.W., Seow, H.F., Rosli, R., Sidik, S., Chong, P.P. (2009). A modified in situ RT-PCR method for localizing fungal-specific gene expression in Candida-infected mice renal cells. Journal

of Microbiological Methods. 2009, 79:242-245.

11. Vidyadaran S., Ooi Y.Y. Subramaiam H., Badiei A., Abdullah M., Ramasamy R., Seow H.F. Effects of macrophage colony-stimulating factor on microglial responses to lipopolysaccharide and beta amyloid.

Cellular Immunology. 2009; 259 (1): 105-110.

12. Yip W.K., Abdullah M.A., Yusoff S.M. and Seow H.F. Increase in tumour-infiltrating lymphocytes with regulatory T cell immunophenotypes and reduced zeta-chain expression in nasopharyngeal carcinoma

patients. Clinical Experimental Immunology. 2009; 155( 3): 412-422.

13. Ching-Shian Leong V, Jabal MF, Leong PP, Abdullah MA, Gul YA, Seow HF. PIK3CA gene mutations in breast carcinoma in Malaysian patients. Cancer Genet Cytogenet. 2008 ;187(2):74-9.

14. Tong CK, Seow HF, Ramasamy R. Cord blood-derived mesenchymal stem cell does not stimulate nor inhibits T lymphocytes activation. Med J Malaysia. 2008;63 Suppl A:77-8.

15. Maha A, Cheong SK, Leong CF, Seow HF. Cell viability of acute myeloid leukaemia blasts in culture correlates with treatment outcome. Hematology. 2008;13(1):13-20

16. Ramasamy R, Tong CK, Seow HF, Vidyadaran S, Dazzi F. The immunosuppressive effects of human bone marrow-derived mesenchymal stem cells target T cell proliferation but not its effector

function. Cell Immunol. 2008;251(2):131-6. (84 citations in Scopus)

17. See HS, Yap YY, Yip WK, Seow HF. Epstein-Barr virus latent membrane protein-1 (LMP-1) 30-bp deletion and Xho I-loss is associated with type III nasopharyngeal carcinoma in Malaysia. World J Surg

Oncol. 2008;6:18.

18. Yip WK, Leong VC, Abdullah MA, Yusoff S, Seow HF. Overexpression of phospho-Akt correlates with phosphorylation of EGF receptor, FKHR and BAD in nasopharyngeal carcinoma.Oncol Rep.

2008;19(2):319-28. (37 citations in Scopus)

19. Seow, HF. Biomarkers in cancer: an update (a review), Malaysian J of Medical and Health Sciences, 2008, 4: 23-32.

V.C. Yong, R. Rozita, H.F. Seow, P.P. Chong Identification of Candida tropicalis Immunoreactive

Proteins by Immunoproteomics International Journal of Infectious Diseases . December 2008 (Vol.

12Supplement 1, Pages e175-e176)

20. Chong PP, Abdul Hadi SR, Lee YL, Phan CL, Tan BC, Ng KP, Seow HF. Genotyping and drug resistance profile of Candida spp. in recurrent and one-off vaginitis, and high association of non-albicans

species with non-pregnant status. Infect Genet Evol. 2007, 7(4), 449-456 (28 citations in Scopus)

21. Tan GH, Yusoff K, Seow HF, Tan WS. A phage-displayed single chain variable fragment that interacts with hepatitis B core antigen: library construction, selection and diagnosis. J Clin Virol. 2007

Jan;38(1):49-56. Epub 2006 Oct 30. [impact factor = 2.63]

22. Leong PP, Rohaizak, Natiquah, H. Ithnin, Maha A., Davis W., Seow HF. Phenotyping of lymphocytes in infiltrating ductal breast carcinoma. Immunol. Letts., 2006, 102:229-236.

http://www.ncbi.nlm.nih.gov/pubmed/19810039?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2http://www.ncbi.nlm.nih.gov/pubmed/19810039?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2http://www.ncbi.nlm.nih.gov/pubmed/19577228?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=4http://www.ncbi.nlm.nih.gov/pubmed/19577228?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=4http://www.ncbi.nlm.nih.gov/pubmed/19220831?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=5http://www.ncbi.nlm.nih.gov/pubmed/19220831?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=5http://www.ncbi.nlm.nih.gov/pubmed/19220831?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=5http://www.ncbi.nlm.nih.gov/pubmed/19027487?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/19027487?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/19024992?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/19024992?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18534060?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18534060?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18502411?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18502411?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18502411?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18275617?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18275617?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18202777?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/pubmed/18202777?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17324639&query_hl=1&itool=pubmed_docsumhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17074533&query_hl=1&itool=pubmed_docsum

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[impact factor = 3.049]

23. Khor Tin Oo, Hairuszah Ithnin, Yunus Gul A. Gul, Heng Fong Seow. A comparative study of the expression of Wnt-1, WISP-1, survivin and cyclin D1 in colorectal carcinoma. Internat. J

Colorectal Disease. (2006) 55 (4): 423-428. ( 28 citations in Scopus)

24. Chong PP, Chieng DC, Low LY, Hafeez A, Shamsudin MN, Seow HF, Ng KP. Recurrent candidaemia in a neonate with Hirschsprung's disease: fluconazole resistance and genetic relatedness of eight Candida

tropicalis isolates. J Med Microbiol. 2006 Apr;55(Pt 4):423-8.

25. 26. Leong PP and Seow HF. Cancer Immunotherapy. Malaysian J of Medicine and Health Sciences. 2006, 2:

1-26.

27. 28. Yong, P.V.C., Chew, L.M., Kwan, C.L., Ng, K.P., Seow, H.F., Chong, P.P. (2006). Transcriptional and

sequencing analysis of CtCDR1, CtMDR1 and CtERG11 genes in fluconazole-resistant Candida

tropicalis isolates from candidemia patients. Journal of Medical Sciences 6(5):713-723

Ong HT, Duraisamy G, Ng KP, Tan WS and Seow HF. Genotyping of hepatitis B virus in Malaysia based on the nucleotide sequence of preS and S genes. Microbes and Infection (2005) 7: 494-500.[ impact factor = 3.154] factttor =3.154]

Looi CY, D' Silva EC, Seow HF, Rosli R, Ng KP and Chong PP. Increased expression and hotspot

mutations of the multidrug efflux transporter, CDR1 in azole-resistant Candida albicans isolates from

vaginitis patients. FEMS Microbiol Lett. 2005, 249(2):283-289.

Ng KP, Soo-Hoo TS, Na S, Tay ST, Hamimah H, Lim PC, Chong PP, Seow HF, Chavez AJ and Messer

SA. The mycological and molecular study of Hortaea werneckii isolated from blood and splenic abscess.

Mycopathologia. 2005, 159(4):495-500.

Tan, GH, Yusoff, K, Seow, HF and Tan, WS. Antigenicity and immunogenicity of the

immunodominant region of hepatitis B surface antigen displayed on bacteriophage T7. J Med Virol.

2005, 77(4):475-80.

Tan, WS, Tan, GH, Yusoff, K. and Seow, HF. A phage-displayed cyclic peptide that interacts tightly

with the immunodominant region of hepatitis B surface antigen. J Clin Virol. 2005, 34(1):35-41.

Heng F Seow, Stefan Bröer, Angelika Bröer, Charles G Bailey, Simon J Potter, Juleen A

Cavanaugh, John E J Rasko Hartnup disorder is caused by mutations in the gene encoding the

neutral amino acid transporter SLC6A19. (2004) Nature Genetics 36, 1003 – 1007. [impact factor

=25.277], 110 citations in Scopus.

KHOR, T.O., YUNUS A. G., HAIRUSZAH I. and SEOW, H.F. 2004. Positive correlation of pBAD

with pAkt-Ser 473 but not pAKT-Thr 308 expression in colorectal carcinoma. Cancer Letters

210: 139-150. [impact factor = 3.049]

Ban KC, Harjit Singh, R. Krishnan and Seow HF. Comparison of beta catenin expression in

hepatocellular carcinoma from areas of high and low aflatoxin exposure. J. Surgical Oncology 2004, 86,

Issue 3, 2004. Pages 157-163.

HONG, S.K., YUNUS ALIF GUL, HAIRUSZAH I., ARNI T. and SEOW, H.F. Expression of β-catenin,

COX-2 and iNOS in colorectal cancer – implications of the relevance of COX-2 and iNOS inhibitors for

treatment in Malaysia?’ Asian Journal of Surgery, 2004, 27, 10-17.

Kong LL, Omar AR, Hair-Bejo M, Aini I, Seow HF 2004. Comparative analysis of viral RNA and

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16533990&query_hl=1&itool=pubmed_docsum

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apoptotic cells in bursae following infection with infectious bursal disease virus. Comp.Immunol.

Microbiol. Infect. Dis 27(6) 433-443.

Kong, LL, Omar AR, Hair-Bejo M, Aini I, Seow HF. Sequence analysis of both genome segments of

two very virulent infectious bursal disease virus field isolates with distinct pathogenicity. Arch

Virol. 2004 Feb;149(2):425-34.

HO, K.L., YUSOFF, K., SEOW, H.F., TAN, W.S. Selection of high affinity ligands to hepatitis B core

antigen from a phage-displayed cyclic peptide library. J Med Virol. 2003 Jan; 69(1):27-32. [impact factor

= 2.3]

BAN K.C., HARJIT S., R. KRISHNAN2, SEOW, H.F. GSK-3β Phosphorylation and Alteration of

β-Catenin in Hepatocellular Carcinoma Cancer Letters (2003), 1999: 201-208.[impact

factor=3.049], 44 citations in Scopus.

CHIA, C.S., BAN K., HAIRUSZAH I., HARJIT, S., KRISHNAN, R., SURYATI M., MALIHAN, N.,

SEOW, H.F. Expression of IFN-γ, IL-18 and IL-10 in hepatocellular carcinoma. Immunology Letts.

(2002) 84:3 163-72 [impact factor=2.3]

HO, K.L., TAN, W.S., SEOW, H.F. and KHATIJAH, Y. Identification of peptides that bind Hepatitis B

core proteins by phage display library (Patent filed-Nov 2001).

LEONG C.O. and SEOW H.F. Telomere and telomerase: useful as prognostic factor and targets for

cancer therapy? Clinical BiochemReviews (2001), 23: 39-51.

LI FAN, MICHAELA A. RIDDELL, HENG-FONG SEOW, NAOKAZU TAKEDA, TATSUO

MIYAMURA, and DAVID A. ANDERSON Recombinant subunit ORF2.1 antigen induces antibody

against immunodominant epitopes in the hepatitis E virus capsid protein. J Med Virol. 2000, 60: 379-

386.

RIFFKIN M. C., H-F. SEOW, P. R. WOOD, L. E. BROWN, D. C. JACKSON and J.-P. Y.

SCHEERLINCK. Trichostrongylus colubriformis extract up-regulates TNF-a receptor expression and

enhances TNF-a mediated lysis of L929 cells. Immunol. Cell Biol. 2000 , 78:6, 575-579

BAN K. and SEOW H.F. Molecular Events associated with hepatocellular carcinoma. International

Journal for Medical Research (2000) , 4: 7-21.

SEOW HF, NIZAM MBM, MAK JW, RIDDELL, M., LI F and ANDERSON D. Seroprevalence of

antibodies to Hepatitis E Virus in the normal blood donor population and two aboriginal communities in

Malaysia. J. Med. Virol. 1999, 59:164-168.

ANDERSON DA, LI F, RIDDELL M, HOWARD T, SEOW HF, TORRESI J, PERRY G,

SUMARISIDI D, SHRESTHA SM, SHRESTHA IL. ELISA for IgG-class antibody to hepatitis E

virus based on a highly conserved conformational epitope expressed in Escherichia coli. J. Virol

Methods. 1999, 81, 131-142. (49 citations in Scopus)

WONG GW, MANAF A and SEOW HF. Cloning, expression of human interleukin-18 expression and

the effects of chemical stimuli. Asian Pacific J Biotech and Mol Biol, 1999, 7(2): 1-11.

SEOW, H.F. Cytokines and the immune response. Malaysian Journal of Clinical Biochemistry, 1999, 2:

42-46.

SEOW HF. Hepatitis B and C in pregnancy. Current Obstetrics and Gynaecology, 1999, 9, 216-223.

ROTHEL, J.S., CORNER, L.A., LIGHTOWLERS, M.W., SEOW, H.F., McWATERS, P., ENTRICAN,

9 / 2

G. and WOOD, P.R. Antibody and cytokine responses in efferent lymph following vaccination with

different adjuvants. Vet. Immunol. Immunopath. 1998, 63: 167-183.

ROTHEL, J.S., SEOW, H-F., LIGHTOWLERS, M.W., PARRY, B., GAUCI, C., HURST, L., MUCHA,

M-J., CORNER, L.A. and WOOD, P.R. The use of recombinant ovine IL- -

adjuvants and their physiological effects in vivo. Immunol. Cell Biol., 1998, 76:2, 167-172.

SEOW, H-F. Pathogen interactions with cytokines and host defense: an overview. Vet, Immunol.

Immunopath., 1998, 63, 139-148.

PERSSON K., COLDITZ I.G., FLAPPER P. and SEOW H-F. Leukocyte and cytokine accumulation in

the ovine teat and udder during endotoxin-induced inflammation. Veterinary Research Communications,

1997, 21:2, 101-115.

PERSSON K., COLDITZ I.G. and SEOW H-F Accumulation of leukocyte and cytokine in the lactating

ovine udder during Staphylococcus aureus and Escherichia coli mastitis. Research in Veterinary Science

1997, 62, 63-66.

WONG, C.W., SEOW, H-F., LIU, A.H., HUSBAND, A..J., SMITHERS, G.W. and WATSON, D.L.

Effects of purified bovine whey factors on cellular immune functions in ruminants. Vet. Immunol.

Immunopath., 1997, 56, 85-96.

ROTHEL, J.S., WATERKEYN, J., STRUGNELL, R.A., WOOD, P.R. SEOW, H-F. and

LIGHTOWLERS, M.W. Nucleic acid vaccination of sheep: use in combination with a conventional

adjuvanted vaccine against Taenia ovis. Immunol. Cell Biol., 1997, 75:41-46.

SEOW, H-F., DAVID, M-J., HURST, L., ROTHEL, J.S. and WOOD, P.R. Expression of ovine

interleukin-2 cDNA in Escherichia coli. Vet. Immunol. Immunopath. 1997, 56: 107-117.

ROTHEL, J.S., HURST, L., PEPIN, M., CORNER, L.A., BERTHON, P., SEOW, H-F., and WOOD,

P.R. Analysis of ovine IL-1ß production in vivo and in vitro by ELISA and immunohistochemistry. Vet.

Immunol. Immunopath. 1997 , 57, 267-278.

PEPIN, M, SEOW, H-F., CORNER, L.A., ROTHEL, J.S. HODGSON, A.L.M and WOOD, P.R.

Cytokine gene expression in sheep following experimental infection with various strains of

Corynebacterium pseudotuberculosis differing in virulence. Veterinary Research., 1997, 28 (2), 149-163.

ROTHEL, J.S., WOOD, P.R., SEOW, H-F. and LIGHTOWLERS, M.W. Urea/DTT solubilization of a

recombinant 45W-GST fusion protein results in enhanced protective immune response to the 45W moiety.

Vaccine, 1997, 15, 469-472.

LECHNER, F., MACHADO, J., BERTONI, G., SEOW, H-F., DOBBELAERE, D.A.E. and

PETERHANS, E. Caprine arthritis encephalitis virus dysregulates the expression of cytokines in

macrophages. J. Virol. 1997, 71: 7488-7497.

LECHNER, F., VOGT, H.R., SEOW, H.F., BERTONI, G., CHEEVER, W.P., voN BODUNGEN, U.,

ZUBRIGGEN, and PETERHANS, E. Expression of cytokine mRNA in lentivirus-induced arthritis.

American J. Pathology, 1997, 151: 1053-1065.

WOOD, P.R. and SEOW, H-F. T cell cytokines and disease prevention. Vet. Immunol. Immunopath.,

1997, 54, 33-44.

NASH, A., ANDREWS A., MARTIN, H., COLDITZ, I.G., WOOD, P. and SEOW, H-F .Methods for

detection and assay of ovine cytokines. In: Immunology Methods, Academic Press, 1997, Chapter 31.13,

edited by Ivan Lefkovits

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SEOW H-F., DAVID, M-J., MCWATERS, P, HURST, L. and P.R. WOOD. Cloning of ovine

interleukin-5 cDNA. DNA Sequence. J. of Sequencing and Mapping, 1996, 6, 331-335.

HAIG, D., DEANE D., PERCIVAL, A., MYATT, N., THOMSON, J., INGLIS, L., ROTHEL, J.S.,

SEOW H-F., WOOD, P.R., MILLER, H.R.P. and REID, H.W. The cytokine response of efferent lymph

following orf virus reinfection of sheep. Veterinary Dermatology, 1996, 7, 11-20.

HAIG, D.M., MCINNES, C., DEANE,D., LEAR, A., MYATT, N., REID, H., ROTHEL, J., SEOW, H-

F., WOOD, P., LYTTLE, D. and MERCER, A. Cytokines and their inhibitors in orf virus infection. Vet.

Immunol. Immunopath., 1996, 54: 261-267.

LECHNER, F., VOGT., HR., BERTONI, F., SEOW, H.F., ZUBRIGGEN, A. and PETERHANS, E.

Expression of TNF- Vet. Immunol. Immunopath., 1996, 54: 281-289.

ROTHEL, J.S., LIGHTOWLERS, M., SEOW, H-F. and WOOD, P.R., HEATH, D. and HARRISON, G.

Immune response associated with protection is sheep vaccinated with a recombinant antigen from Taenia

ovis, Parasite Immunology, 1996, 18: 201-208.

ROTHEL, J.S., CORNET, L.A., SEOW, H-F., WOOD, P.R. AND LIGHTOWLERS, M.W. Antigen-

specific IgA-secreting cells induced by peripheral vaccination. Immunology and Cell Biology, 1996, 74,

298-300.

WONG, C.W., SEOW,H-F., LIU, A.H.,HUSBAND, A.J., SMITHERS, G.W. AND WATSON,

D.L. Modulation of immune responses by bovine -casein. Immunol. Cell Biol.,1996, 74, 323-329.

MERTENS, B. and SEOW, H-F. The nucleotide sequence of bovine interleukin-5 cDNA. Gene,

1996, 176, 273-274.

PERSSON K., COLDITZ I.G., FLAPPER P., FRANKLIN N.A.F., SEOW H-F. Cytokine-

induced inflammation in the ovine teat and udder.Vet. Immunol. and Immunopath.1996, 53, 73-85.

EGAN, P.J., KIMPTON, W., SEOW, H-F., BOWLES, V.M., BRANDON, M.R. and NASH, A.D.

Inflammation-induced changes in the phenotype and cytokine profile of cells migrating through skin and

afferent lymph. Immunology, 1996, 89: 539-546.

HAIG, D.M., MCINNES, C.J., HUTCHISON, G., SEOW, H-F. And REID, H.W. Cyclosporin A

abrogates the acquired immunity to cutaneous reinfection with parapoxvirus orf virus. Immunology, 1996,

89: 524-531.

RIFFKIN, M., SEOW, H-F., BROWN, L., JACKSON,D. AND WOOD, P.R. Defense against immune

barrage: evasive strategies of helminth parasites. Immunol. Cell Biol. 1996 , 74: 564-574.

EGAN P.J., ROTHEL J.S., ANDREWS A.E., SEOW H-F., WOOD P.R. and NASH A.D.

Characterization of monoclonal antibodies to ovine tumor necrosis factor-10

sensitive immunoassay. Veterinary Immunology & Immunopathology, 1994, 41, 259-274.

SEOW H-F., YOSHIMURA T., WOOD P.R. and COLDITZ I.G. Cloning, sequencing, expression and

inflammatory activity in skin of ovine interleukin-8. Immunology and Cell Biology, 1994, 72, 398-405.

SEOW H-F., ROTHEL J.S. and WOOD P.R. Expression and purification of recombinant ovine

interleukin-1ß from Escherichia coli. Veterinary Immunology and Immunopathology, 1994, 41, 229-239.

ELHAY M.J., HANRAHAN, C.F., BOWLES, V.M., SEOW, H-F., ANDREWS, A.E. and NASH, A.D.

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Cytokine mRNA expression in skin in response to ectoparasite infection. Parasite Immunology, 1994, 16,

451-461.

HAIG D.M., McINNES C.J., WOOD P.R. and SEOW H.F. The cytokines: origin, structure and function.

In: Cell Mediated Immunity in Ruminants, pp. 75-92. (Eds. B. Goddeeris and I. Morrison). Boca Raton,

Fla., CRC Press, 1994.

WOOD P.R., SEOW H-F., ROTHEL, J.S. Cytokines and the regulation of immune response. In:

Vaccines in Agriculture: Immunological Applications to Animal Health and Production, pp. 49-56 (eds.

Wood,P.R., Willadsen, P., Vercoc, J.E., Hoskinson, R.M., Denmeyer, D.), East Melbourne, Victoria,

CSIRO, 1994

Patents filed (1)

ROTHEL J.S., SEOW, H-F, CORNER L.A., WOOD, P.R. International Patent Application No.

PM5438/94 on An Adjuvant.

SEOW H-F., ROTHEL J.S. and WOOD P.R. Cloning and sequencing an ovine interleukin-4-encoding

cDNA. Gene, 1993, 124, 291-293.

SEOW H.F., ROTHEL J.S., CORNER L.A. and WOOD P.R. Cloning of cervine interferon-gamma

cDNA by polymerase chain reaction. New Zealand Veterinary Journal, 1993, 41, 91-95.

O'BRIEN, SEOW, H-F., ROTHEL, J.S. and WOOD, P.R. Cloning and sequencing of an ovine

granulocyte-colony stimulating factor cDNA. DNA Sequence: J. Sequencing and Mapping, 1995, 4, 339-

342.

SEOW H-F., ROTHEL J.S., M. PEPIN, DAVID, M.J. and WOOD, P.R. Expression, biological activity

and kinetics of expression of ovine TNF- Veterinary Immunology and Immunpathology, 1995, 44, 279-

291.

O'BRIEN P.M., SEOW H.F., COUPAR, B., ENTRICAN G., WOOD, P.R. Production and

characterisation of ovine GM-CSF expressed in bacterial and mammalian cells. Vet. Immunol.

Immunopathol., 1995, 48, 287-298.

WOOD, P.R. AND SEOW, H-F. Ruminant cytokines and regulation of the immune system. Bulletin de

la Societe Franco-Japonaise des Sciences Veterinaaires, Tome 6, No.2 December , 1995, 50-52.

PERSSON, K., COLDITZ, I. and SEOW, H-F. Role of cytokines in inflammatory responses in the ovine

udder. Proceedings of the Third IDF International Mastitis Seminar, (1995) pp. 35-38

Patents (1)

Seow, H-F. and Wood, P.R. Immune response modulators and uses therefor. Provisional filed 14 June

1995

O'BRIEN P.M., ROTHEL J.S., SEOW H-F. and WOOD P.R. Cloning and sequencing of the cDNA for

ovine granulocyte- macrophage colony-stimulating factor (GM-CSF). Immunology and Cell Biology,

1991, 69, 51-55.

SEOW H-F., ROTHEL J.S., DAVID M-J. and WOOD P.R. Nucleotide sequence of ovine macrophage

interleukin-1 beta cDNA. J. DNA Sequence and Mapping, 1991, 1, 423-426.

Patents

Wood P.R., Seow H-F. and Rothel J.S.Ovine cytokine genes. International Patent Application No.

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2

PCT/AU91/00419 filed 12/9/91.

SEOW H-F., ROTHEL J.S., RADFORD A.J. and WOOD P.R. The molecular cloning of ovine

interleukin 2 gene by the polymerase chain reaction. Nucleic Acids Research, 1990, 18, 7175.

SEOW H-F., GOH C.R., KRISHNAN L. and PORTER A.G. Bacterial expression, facile purification and

properties of recombinant human lymphotoxin (tumor necrosis factor beta). Bio/technology, 1989, 7, 363-

368.

.SCOTT G.K., SEOW H.F. and TSE C.A.. Investigations into the nature of growth-related proteolysis in

human fibroblasts. Biochimica et Biophysica Acta, 1989, 1010, 160-165.

JACKSON A.P., SEOW H.F., HOLMES N., DRICKAMER K. and PARHAM P. Clathrin light

chains contain brain-specific insertion sequences and a region of homology with intermediate

filaments. Nature, 1987, 326, 154-159.

BRODSKY F.M., GALLOWAY C.J., BLANK G.S., JACKSON A.P., SEOW H-F., DRICKAMER K.

and PARHAM P.. Localization of clathrin light-chain sequences mediating heavy- chain binding and

coated vesicle diversity. Nature, 1987, 326, 203-205.

SCOTT G.K. and SEOW H.F. Does a fibroblast membrane proteinase affect the binding, uptake and

metabolism of epidermal growth factor? Comparative Biochemistry and Physiology, 1986, 84B, 595-599.

SCOTT G.K. and SEOW H.F. Further evidence for a cell surface proteinase essential to the growth of

cultured fibroblasts. Experimental Cell Research, 1985, 158, 41-52

HARPER L., SCOTT G.K. and SEOW H.F. Antibody affinity chromatography of human proteinases and

related proteins. Comparative Biochemistry and Physiology, 1984, 78B, 231-235

Books/Monographs Are there “Magic Bullets” for Cancer Therapy, UPM Press, 2011.

Chapter in book Immunomodulatory potential of mesenchymal stem cells on microglia

Recent Invited

Oral presentations

Tumour Immunology, Immunology Symposia, 15-16th October 2014,

Faculty of Medicine and Health Sciences, UPM.

Role of polarised macrophages in the tumour microenvironment. Cancer

Treatment: beyond a microscopic view. Taylor’s University 2-3rd

September 2014.

Are tumorspheres relevant as in vitro models for studying chemoresistance

by cancer stem cells? 3rd Universiti Tunku Abdul Rahman Stem Cell and

iPCS Seminar, 2nd December 2013.

Role of EGFR (epidermal growth factor receptor) and PI3K (phosphatidyl-

inositide-3-kinase)/Akt Signal Pathway in Nasopharyngeal Cancer Cell

Adhesion and Invasion. 6th Annual Conference of the Malaysian Society

for Biochemistry and Molecular Biology Society, 27-28 July 2011, Eastin

Hotel, Petaling Jaya, Selangor.

Research Ethics and Integrity. Postgraduate International Symposium. 16th

September 2011, Petronas University.

H. GRANTS APPROVED Project No. Project Title Role Year Source of Status

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2

fund

GP-IPS/2014/9433958 Identification of potential therapeutic targets for metastastic colon cancer by

inhibition of microRNA expression

Project

leader/Principal

Investigator

Sept

2014-

Aug

2016

Geran

Putra

Siswazah

Ongoing

04-01-14-1455 Cross talk between polarized

macrophages and cancer

stem-like cells influences

tumorigenicity, metastasis

and immune responses

Project

leader/Principal

Investigator

July

2014-

June

2016

FRGS Ongoing

02-01-04-SF1312

Cell migration and

angiogenesis inhibition by

targeting Wnt as a potential

cancer treatment strategy

Project

leader/Principal

Investigator

2012-

2014

MOSTI Completed

02-01-04-SF0347 Discovering signal

transduction inhibitors from

Actinomycetes for potential

anticancer drugs

Project leader/

Principal

Investigator

2007

&

2008

MOSTI Completed

04-01-07-104FR Characterisation of the mode

of action of signal

transduction inhibitors from

Actinomycetes extracts

Project leader

/Principal

Investigator

2007-

2008

MOHE Completed

04/01/07/0113RU

Immunomodulatory effects of

mesenchymal stem cells:

implications for cancer

therapy

Project leader/

Principal

Investigator

2007-

2009

RUGS Completed

(06-02-01-0000-

PR0054/06-04)

Identification of

nasopharyngeal carcinoma

specific Epstein-Barr virus

antigens towards the

development of

cytotoxic T lymphocyte-

based immunotherapy

Project Leader/

Principal

Investigator

2003-

2007

MOSTI Completed

(06-02-

04-005 BTK/ER/023)

Molecular Approaches to the

Diagnosis and Management

of Systemic Fungal

Infections

Program

Leader/

Principal

Investigator

2003-

2007

MOSTI Completed

(06-02-04-0373-

PR002/07-07)

Identification of novel

therapeutic targets for

treatment of breast cancer

Project Leader/

Principal

Investigator

2002-

2004

MOSTI Completed

(06-05-01-

003BTK/ER018)

Molecular studies on disease

biomarkers and pathogenesis

of cancer: colorectal

carcinoma as a model

Project Leader/

Principal

Investigator

2003-

2005

MOSTI Completed

( 09-02-04-0449-

EA001)

Comparison of tumour

markers from various

biological fluids

Project Leader/

Principal

Investigator

2004-

2006

MOSTI Completed

(06-04-02-0083) Characterisation of cytokines

and apoptotic/anti-apoptotic

molecule expression in acute

myeloid leukemia

Project Leader/

Principal

Investigator

2000-

2002

MOSTI Completed

I. TEACHING EXPERIENCE

Role Course/Module

14 /

2

Lecturer (1997-2001)

Module Co-ordinator/Lecturer

(1997-2001)

Lecturer

Module Co-ordinator/Lecturer

(1997-2003)

Course Co-ordinator/Lecturer

Lecturer (2004-2007)

Lecturer (2010-present)

Biochemistry II (MDP 3202; 4 credit hours) – Taught the topics in the

area of metabolism

Medical Microbiology I (MDL 3001; 3 credit hours) – Basic features of

DNA and RNA viruses; clinical diagnostics including serological and

molecular detection methods; antiviral drugs for treatment of viral

infections.

Immunology (MDL 3401; 2 credit hours)

Immunology (SPM 3200)- all 14 lectures; 5 tutorials and 1 practical)

Virology component of Medical Microbiology and Parasitology (SPM

3300)

Molecular Medicine (SPD 3104) – mechanism of cytokine action

Genetic Engineering for biomedical students (2 credits): realtime

quantitative PCR lecture

Immunology for Medical students. (35 contact hours per semester)

Immunology (BMS 3070) for BSc (Hons) Biomedical Sciences. (42

hours per semester)

Immunobiology (SMK5600) for Masters of Science Students.

Immunology in Biotechnology (3 credits: contact hours = 42 h per

semester)

Immunology for Medical Students ; problem-based learning sessions

Immunology for Medical Students

Nutritional Immunology for Nutrition and Dietetics Program

Masters of Medicine (Pathology)

Deputy Dean,

Learning Support Programme,

School of Graduate Studies

UPM (2010-2013)

Created the learning support program is designed with five clusters

towards the development of academic skills such as ethics, scholarly

integrity, writing for publishing and thesis, skills in software application

such as SPSS, SEM and also in soft skills such as in leadership,

communication and team building. In addition, the program includes

activities which involve engagement with the community and schools.

This program is designed to enhance the student experience and acquire

academic skills and emotional intelligence as well as awareness in the

importance of contributions to social and community activities.

Examples of seminars include “Enhancing the Postgraduate Student

Experience”, “Scientific Writing” and “Presentation Skills”. A total of

1300 students have attended these seminars.

Deputy Dean,

Thesis Unit

Oversee the examination process and conduct of the viva voce. Manage

the administration of the Graduate on Time and thesis submission and

conflict resolution. Involved in the preparation of the documents for

accreditation of postgraduate programs according to the MQF

requirements.

J. CONTRIBUTION TO UNIVERSITY

Member of grant evaluation panel for FRGS, eSc, Grant Putra

Member of Human Ethics Committee (2010-2012)

Chairperson of UPM Postgraduate Thesis Examination Committee Appointments (2011-2013)

Chairperson for UPM Thesis Titles (2011-2013)

Committee Member for University Postgraduate Studies (2010-2013)

15 /

2

Member of UPM School of Graduate Studies Management (2010-2013)

Chairperson for Course Evaluation Committee (2004-2006);

Head of Internal Audit for Quality Management System ISO 9001:2000 (2004-2007) : duties include

organizing internal audits at least three times a year with university auditors and staff members;

Committee member of the QMS ISO 9001:2000 to prepare documentation as required by ISO standards;

Committee Member for Faculty Research Committee (2004-2007);

Committee member involved in curriculum development for Master of Pathology postgraduate

programme for medical doctors. The first intake is in 2008;

Committee Member of Equipment Committee, Faculty of Medicine and Health Science, UPM (1997-

2000);

Member of the interviewing panel for new intake of medical students (Year 2000);

Committee member for the student project examination board (1998-1999);

Administrative contract officer responsible for the purchase of all equipment for the Immunology unit

and the Cancer Research Lab, Institute of Bioscience in the year 2000.

K. MEMBER OF EDITORIAL BOARD

Journal of Nasopharyngeal Carcinoma

Malaysian Journal of Pathology

L. REVIEWER OF MANUSCRIPTS FOR JOURNALS

Stem Cells

Clinical Cancer Research

Tumour Biology

International Journal of Cancer

International J. of Science Monitoring

Journal of Immunological Methods

International Immunopharmacology

Medical Journal of Malaysia

Diabetologia

Diabetes

M. EXTERNAL DUTIES

Reviewer of Malaysian Ministry of Science, Innovation and Technology Grants(Technofund, eScience

Fund, eSc grants)

External Examiner for UCSI Biotechnology Program

Member of Assessor Panel for Higher Education Centres of Excellence

N. MEMBERSHIP OF SOCIETIES

i. Australasian Society of Immunology

ii. Who’s Who of the Historical Society