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Curriculum Vitae Personal Name: Urs Emanuel Albrecht Work Address: Universität Fribourg Biochemisches Institut rue du Musée 5 Pérolles CH-1700 Fribourg Tel: ++41 26 300 8636 Fax:++41 26 300 9735 e-mail: urs.albrecht@unifr.ch Home Address: Dorfstrasse 35 1792 Cordast, Switzerland Date of Birth: February 3, 1962 Marital Status: Married, 4 children Nationality: Swiss Education: 1983-1988 Department of Biochemistry, University of Zürich, Switzerland.

Awarded the degree of Dipl. Phil. II in Biochemistry for a thesis entitled “Isolation and partial structural characterization of a novel Heparin-Binding, non FGF-like endothelial cell growth factor”. Advisor: Prof. P. Böhlen.

1989-1993 Department of Zoology, University of Bern, Switzerland. Awarded the degree of Dr. phil. nat. for a thesis entitled “Partial purification of the small nuclear ribonucleoprotein particle U7 and Polydnavirus in the parasitic wasp Chelonus inanitus”.

Advisor: Prof. D. Schümperli Research and professional experience: 1993-1998 Postdoctoral Fellow and Research Associate at the Department of

Biochemistry, Baylor College of Medicine, Houston, USA. (Prof. G. Eichele)

1998-1999 Assistant Professor, Department of Biochemistry, Baylor College of Medicine, Houston, USA.

1999- 2001 Assistant Professor at the Max-Planck Institue for experimental Endocrinology, Hannover, Germany.

2001-present Associate Professor, Dept. of Biochemistry, University of Fribourg, Switzerland

2006-2011 Subproject leader in the integrated project EUCLOCK of the 6th framework program of the European Commission.

2008 Visiting Associate Professor, Dept. of Pediatrics, Unit of Neurology, Baylor College of Medicine, Houston, USA. March 24 – June 31.

2008 Fellow of the Japanese Society for the Promotion of Science (JSPS), November 5 – 20.

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2008-2011 Head of Biochemistry Unit, Department of Medicine, University of Fribourg.

Honors: 1996 V.C. Joshi Memorial Award, Dept. of Biochemistry, Baylor College

of Medicine 1997 “Science”, in the top ten breakthroughs of the year 1998 V.C. Joshi Memorial Award, Dept. of Biochemistry, Baylor College

of Medicine 2005 Cloëtta-Prize for Medicine Funding Awards: 1992 USGEB/USSBE Travel Award 1995-1996 Swiss National Science Foundation Fellowship for advanced

researchers (No. 823A-042999) 2000-2002 Award from the DFG (Deutsche Forschungs Gemeinschaft) for a

project entitled “Molecular Mechanisms of the Circadian Clock”. (AL 549/1-1) 2000-2002 Award toghether with E. Maronde from the DFG for a project

entitled “Mammalian circadian synchronizers”. (MA 2277/2-1) 2000-2002 Award from the DFG for a project entitled “Genetic interaction

between mammalian per and cry genes” (AL 549/3-1) as part of the Schwerpunktprogramm “Funktionelle und adaptive Mechanismen circadianer Systeme”(SPP 1002)

2001-2004 Award from the SNF (Swiss National Science Foundation) for a project entitled “Circadian Rhythms: from Genes to Behavior”.

(3100-063653.00/1) 2001-2002 Award from the AETAS foundation for a project entitled: “The

circadian clock and ageing”. 2001-2002 Award from the Novartis foundation for a project entitles: “Genetic

interaction between Per and Cry genes” 2002-2005 Award from the European Union and the Swiss Office for Education

and Science for a joint project in the 5th Framework program entitled: "BRAINTIME: The biological clock in the brain: circadian genes and the sense of time" Contract Number QLG3-CT-2002-01829

2004-2007 Award from the SNF (Swiss National Science Foundation) for a project entitled “The circadian clock, transcriptional regulation and aging”. (3100A0-104222/1)

2005 Programme d’action intégrées franco-suisse ‘Germaine de Staël’ for a project entitled ‘Molekulare und funktionelle Synchronisation der inneren Uhr durch Nahrung’ SANW-04-01

2006-2011 Award from the European Union for a joint project in the 6th Framework program entitled: "EUCLOCK: entrainment of the circadian clock". Contract Number LSHG-CT-2006-018741

2007-2009 Award from the Velux-Foundation for a project entitled “The circadian clock, light and depression”.

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2007 Award from the SNF (Swiss National Science Foundation) in the R’Equip program for a project entitled “Flow cytometry opens new avenues for cell-based anaylses in biomedical reserach” toghether with R. Schneiter et al.

2007-2010 Award from the SNF (Swiss National Science Foundation) for a project entitled “Adaptation mechanisms of the circadian clock to light and temperature” (3100A0-115984/1).

2009-2010 Award from the Novartis foundation for a project entitled: “Restoration of Food Anticipatory Activity in Mice with Defective Period Genes”

2010-2013 Award from the Japanese-Swiss Science and Technology Programm for a project entitled: "The circadian clock and mood disorders - from animal models to human disease".

2010-2013 Award from the SNF (Swiss National Science Foundation) for a project entitled “Adaptation mechanisms of the circadian clock to light and temperature” continuation 'bonus of excellence' (31003A_131086/1).

2010 Award from the SNF (Swiss National Science Foundation) in the R’Equip program for a project entitled “Fluorescence-Mediated Tomography (FMT) to study cellular and molecular events in physiology and pathology: application to cancer, cardiovascular and circadian biology” toghether with Curzio Rüegg et al.

2012-2015 Award from the Velux-Foundation for a project entitled “Influence of light on brain clocks and mood related behavior”.

2012-2015 Award from the SNF (Swiss National Science Foundation) in the Sinergia program (Coordinator: Nelly Pitteloud, Lausanne), for a project entitled “FGF21 is a link between reproduction and energy balance” with a subproject entitled “Circadian clocks – regulation of FGF21 to integrate metabolism and reproductive fitness?” CRSII3_141960/1

2013-2016 Award from the SNF (Swiss National Science Foundation) for a project entitled: “Clock synchronization: from brain to periphery or periphery to brain?” 31003A_146265/1

2014 Award from the SNF (Swiss National Science Foundation) in the R’Equip program for a project entitled “Microchip-based flow cell sorting in biomedicine and material sciences” toghether with Curzio Rüegg et al.

Publication ID: (Google Scholar) 12459 citations, h-factor: 49 Patents: 2001 Mammalian circadian rhythm-like gene. United States Patent: 6,190,882 EC: C07K14/47 Inventors: C.C. Lee, U. Albrecht, G. Eichele, Z.S. Sun 2001 Mammalian circadian regulator M-RIGUI2 (MPER2)

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United States Patent: 6,210,923 EC: C07K14/47A1 Inventors: C.C. Lee, U. Albrecht, G. Eichele, Z.S. Sun 2002 Method for using transfectable constructs from luciferase and from

the promoter of the human Period1 gene for identifying novel active substances that influence the day/night rhythm and sleep. EC: A61K38/20F; A61K38/22 Inventors: D. Motzkus, E. Maronde, S. Loumi, U. Albrecht

Editorial Board: 2007 Chronobiology International 2009 Review Editor Frontiers in Molecular Neuroscience 2010 Genetics Research International 2013 Journal of Circadian Rhythms 2014 Academic Editor PLOS One Professional Associations: 2002-2005 Vice President of USGEB/USSBE (Union of Swiss Societies for Experimental

Biology) Member of: Swiss Society of Molecular and Cellular Biosciences (SSMCB) LS2 (former USGEB) Swiss Society for Neuroscience Society for research on biological rhythms Indian Society for Chronobiology Organization of Meetings and Courses: 2002 Course and minisymposium entitled 'Making sense of genes: Analysis of mouse

mutants'. 3ème cycle Romand en Sciences Biologiques. 2003 Mentor in the Mentoring Program 1 for the support of women in science. 2004 Organization Committee of USGEB meeting 2004 in Fribourg. 2006 Organization Committee for BENEFRI workshop in Neuroscience 2007 Advisor for EU Integrated Action Program Proust 2008 Organization Committee for BENEFRI workshop in Neuroscience 2009 Organization Committee for the Annual Meeting of the Swiss Society for

Neuroscience 2010 Organization Committee for BENEFRI workshop in Neuroscience 2012 Organization Committee for BENEFRI workshop in Neuroscience 2012 Organization of the 1st Swiss Chronobiology Meeting in Fribourg 2013 Organization of the 2nd Swiss Chronobiology Meeting in Fribourg 2014 Organization of Symposium in the 26th Annual Meeting of the SLTBR, Vienna,

Austria Rewiewing panels:

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a) Granting Agencies

Deutsche Forschungsgemeinschaft (DFG) INSERM, Paris, France Agence National de la Recherche (ANR), France Israeli Science Foundation (ISF) German Israeli Foundation for Scientific Research and Development (GIF) Netherlands Organisation for Scientific Research (NWO) The Wellcome Trust, UK Medical Research Council (MRC), UK Biotechnology and Biological Sciences Research Council (BBSRC), UK National Science Foundation (NSF), USA Austrian Science Fund Japanese Society for the Promotion of Science (JSPS) Swiss National Science Foundation (SNF) Velux Foundation, Switzerland European Research Council (ERC) Academy of Finland b) Scientific Journals BMC Neurosci, BMC Mol Biol, Biochem J, Chronobiol Int, Genes Dev, EMBO J, EMBO reports, Curr Biol, J Biol Chem, J Biol Rhythms, FASEB J, Front. Mol. Neurosci., Eur J Neurosci, J Neurosci, J Neurochem, Mol. Cell. Biol., Nature, Neuron, Neurosci Res, Neurosci Lett, PLoS Biol, PLoS One, Proc Natl Acad Sci USA, Science, Science Transl. Med. Teaching University of Fribourg: Biochemistry Cell Biology Chronobiology Bachelor, Master, Medical School and PhD level

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Peer reviewed publications: 1. P. Böhlen, T. Müller, P. Gautschi-Sova, U. Albrecht, C. G. Rasool, M. Decker, A. Seddon, V.

Fafeur, I. Kovesdi, P. Kretschmer. “Isolation from bovine brain and structural characterization of HBNF, a heparin-binding neurotrophic factor”. Growth Factors 4, 97-107, 1991.

2. H.O. Smith, K. Tabiti, G. Schaffner, D. Soldati, U. Albrecht, and M.L. Birnstiel. “Two- step affinity purification of U7 small nuclear ribonucleoprotein particles using complementary biotinylated 2’-O-methyl oligoribonucleotides”. Proc. Natl. Acad. Sci. USA 88, 9784-9788, 1991.

3. R. Mital, U. Albrecht and D. Schümperli. “Detection of UV-induced RNA:protein crosslinks in snRNPs by oligonucleotides complementary to the snRNA”. Nucl. Acids Res. 21, 1049-1050, 1993.

4. U. Albrecht, T. Wyler, R. Pfister-Wilhelm, A. Gruber, P. Stettler, P. Heiniger, E. Kurt, D. Schümperli and B. Lanzrein. “Polydnavirus of the parasitic wasp Chelonus inanitus (Braconidae): characterization, genome organization and time point of replication”. J. Gen. Virol. 75, 3353-3363, 1994.

5. O. Reiner, U. Albrecht, M. Gordon, K. A. Chianese, C. Wong, O. Gal-Gerber, T. Sapir, L.D. Siracusa, A. M. Buchberg, C. T. Caskey and G. Eichele. “Lissencephaly gene (LIS1) expression in the CNS suggests a role in neuronal migration” (Cover). J. Neurosci. 15, 3730-3738, 1995.

6. U. Albrecht, R. Abu-Issa, B. Rätz, M. Hattori, J. Aoki, H. Arai, K. Inoue and G. Eichele. “Platelet-activating factor acetyl hydrolase expression and activity suggest a link between neuronal migration and platelet-activating factor”. Dev. Biol. 180, 579-593, 1996.

7. S.K. Sharan, M. Morimatsu, U. Albrecht, D.-S. Lim, E. Regel, C. Dinh, A. Sands, G. Eichele, P. Hasty and A. Bradley. “Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2” (Cover). Nature 386, 804-810, 1997.

8. U. Albrecht, J.S. Sutcliffe, B.M. Cattanach, C.V. Beechey, D. Armstrong, G. Eichele, A.L. Beaudet. “Imprinted expression of the murine Angelman syndrome gene Ube3a in hippocampal and Purkinje neurons”. Nature Genetics 17, 75-78, 1997.

9. Z. S. Sun, U. Albrecht, O. Zhuchenko, J. Bailey, G. Eichele, C. C. Lee. “RIGUI, a putative mammalian ortholog of the Drosophila period gene”. Cell 90, 1003-1011, 1997.

10. U. Albrecht, Z.S. Sun, G. Eichele, C. C. Lee. “A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light”. Cell 91, 1055-1064, 1997.

11. S. M. Morris, U. Albrecht, O. Reiner, G. Eichele, L.-y. Yu-Lee. “The lissencephaly gene product Lis1, a protein involved in neuronal migration, interacts with a nuclear movement protein, NudC”. Curr. Biol. 8, 603-606, 1998.

12. Y. Jiang, D. Armstrong, U. Albrecht, C.M. Atkins, J.L. Noebels, G. Eichele, J.D.Sweatt, A.L. Beaudet. “Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation”. Neuron, 21, 799-811, 1998.

13. R. B. Lanz, N.J. McKenna, S.A. Onate, U. Albrecht, J. Wong, S.Y. Tsai, M.-J. Tsai and B.W. O’Malley. “A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex”. Cell, 97, 17-27, 1999.

14. B. Zheng, D.W. Larkin, U. Albrecht, Z.S. Sun, M. Sage, G. Eichele, C.C. Lee and A. Bradley. “The mPer2 gene encodes a functional component of the mammalian circadian clock”. Nature 400, 169-173, 1999.

15. P. Liu, M. Wakamiya, M.J. Shea, U. Albrecht, R.R. Behringer and A. Bradley. “Requirement for Wnt3 in vertebrate axis formation”. Nature Genetics 22, 361-365, 1999.

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16. D. Motzkus, E. Maronde, U. Grunenberg, C.C. Lee, W.-G. Forssmann and U. Albrecht. “The human PER1 gene is transcriptionally regulated by multiple signalling pathways”. FEBS Lett., 486, 315-319, 2000.

17. S. Daan, U. Albrecht, G.T.J. Van der Horst, H. Illnerova, T. Roenneberg, T.A. Wehr, W.J. Schwartz. “Assembling a clock for all seasons: are there M and E oscillators in the genes?”. J. Biol. Rhythms, 16, 105-116, 2001.

18. U. Albrecht, B. Zheng, D. Larkin , Z.S. Sun and C.C. Lee. “mPer1 and mPer2 are essential components for normal resetting of the circadian clock”. J. Biol. Rhythms, 16, 100-104, 2001.

19. R. Brandstätter, U. Abraham and U. Albrecht. “Initial demonstration of rhythmic Per gene expression in the hypothalamus of a non-mammalian vertebrate, the house sparrow”. NeuroReport, 12, 1167-1170, 2001.

20. B. Zheng, U. Albrecht, K.Kaasik, M. Sage, W. Lu, S. Vaishnav, Q. Li, Z.S. Sun, G. Eichele, A. Bradley, C.C. Lee. “Non-redundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock”. Cell, 105, 683-694, 2001.

21. H. De Leersnyder, M.C. De Blois, B. Claustrat, S. Romana, U. Albrecht, J.C. Von Kleist-Retzow, B. Delobel, G. Viot, S. Lyonnet, M. Vekemans, A. Munnich. “Inversion of the circadian rhythm of melatonin in the Smith-Magenis syndrome”. J. Pediatr., 139, 111-116, 2001.

22. U. Albrecht and Henrik Oster. “The circadian clock and behavior”. Behav. Brain. Res., 125, 89-91, 2001.

23. A. Avivi, U. Albrecht, H. Oster, A. Joel, A. Beiles and E. Nevo. “Biological clock in total darkness: The Clock/MOP3 circadian system of the blind subterranean mole rat. Proc. Natl. Acad. Sci., 98, 13751-13756, 2001.

24. D. Motzkus, U. Albrecht, E. Maronde. “The human PER1 gene is inducible by interleukin-6”. J. Mol. Neurosci., 18, 105-109, 2002.

25. S. Steinlechner, B. Jacobmeier, F. Scherbarth, H. Dernbach, F. Kruse, U. Albrecht. "Robust circadian rhythmicity of Per1 and Per2 mutant mice in constant light and dynamics of Per1 and Per2 gene expression under long and short photoperiods". J. Biol. Rhythms 17, 202-209, 2002.

26. C. Abarca, U. Albrecht, R. Spanagel. "Cocaine sensitization and reward are under the influence of circadian genes and rhythm". Proc. Natl. Acad. Sci. 99, 9026-9030, 2002.

27. N. Preitner, F. Damiola, L. Lopez-Molina, J. Zakany, D. Duboule, U. Albrecht and U. Schibler. "The orphan nuclear receptor rev-erbα controls circadian transcription within the positive limb of the mammalian circadian oscillator". Cell 110, 251-260, 2002. F1000

28. A. Avivi, H. Oster, A. Joel, A. Beiles, U. Albrecht, E. Nevo. "Circadian genes in a blind subterranean mammal II: Conservation and uniqueness of the three Period homologs in the blind subterranean mole rat, Spalax ehrenbergi". Proc. Natl. Acad. Sci. 99, 11718-11723, 2002.

29. U. Abraham, U. Albrecht, E. Gwinner, R. Brandstätter. "Spatial and temporal variation of passerPer2 gene expression in the suprachiasmatic hypothalamus of the house sparrow (Passer domesticus)". Eur. J. Neurosci. 16, 429-436, 2002.

30. H. Oster, A. Yasui, G.T.J. van der Horst, U. Albrecht. "Disruption of mCry2 restores circadian rhythmicity in mPer2 mutant mice". Genes Dev., 16, 2633-2638, 2002. F1000

31. C. Kopp, U. Albrecht, B. Zheng, I. Tobler. "Homeostatic sleep regulation is preserved in mPer1 and mPer2 mutant mice". Eur. J. Neurosci., 16, 1099-1106, 2002.

32. H. Oster, A. Avivi, A. Joel, U. Albrecht, E. Nevo. "A switch from diurnal to nocturnal activity in the mole rat Spalax ehrenbergi superspecies is accompanied by an uncoupling of the ligth input and the circadian clock". Curr. Biol., 12, 1919-1922, 2002.

33. H. Oster, C. Werner, M.C. Magnone, H. Mayser, R. Feil, M.W. Seeliger, F. Hofmann, U. Albrecht. “cGMP-dependent protein kinase II alters mPer1 and mPer2 gene induction and influences phase shifts of the circadian clock”. Curr. Biol., 13, 725-733, 2003.

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34. H. Oster, S. Baeriswyl, G.T.J. van der Horst, U. Albrecht. “Loss of circadian rhythmicity in aging mPer1-/-mCry2-/- mutant mice”. Genes Dev., 17, 1366-1379, 2003.

35. H. Oster, G.T.J. van der Horst, U. Albrecht. “Daily variation of clock output gene activation in behaviorally arrhythmic mPer/mCry triple mutant mice”. Chronobiol. Int., 20, 683-695, 2003.

36. U. Abraham, U. Albrecht, R. Brandstätter. “Hypothalamic circadian organization in birds. II clock gene expression”. Chronobiol. Int., 20, 657-669, 2003.

37. A.Avivi, H. Oster, A. Joel, A. Beiles, U. Albrecht, and E. Nevo. “Circadian Genes in a Blind Subterranean Mammal III: Molecular Cloning and Circadian Regulation of Cryptochrome Genes in the Blind Subterranean Mole Rat, Spalax ehrenbergi Superspecies”. J. Biol. Rhythms, 19, 22-34, 2004.

38. K.Spoelstra, U. Albrecht, G. T. J. van der Horst, V. Brauer and S.Daan. ‘Phase responses to light pulses in mice lacking functional per or cry genes’. J. Biol. Rhythms, 19, 518-529, 2004.

39. M.C. Magnone, B. Jacobmeier, C. Bertolucci, A. Foà and U. Albrecht. ‘Circadian expression of the clock gene Per2 is altered in the ruin lizard (Podarcis sicula) when temperature changes’. Mol. Brain Res., 133: 281-285, 2005.

40. R. Spanagel, G. Pendyala, C. Abarca, T. Zghoul, C. Sanchis-Segura, M. C. Magnone, J. Lascorz, M. Depner, D. Holzberg, M. Soyka, S. Schreiber, F. Matsuda, M. Lathrop, G. Schumann and U. Albrecht. ‘The clock gene Period2 influences the glutamatergic system and thereby modulates alcohol consumption’. Nat. Med., 11: 35-42, 2005. F1000

41. M. J. Vansteensel, M. C. Magnone, F. van Oosterhout, S. Baeriswyl, U. Albrecht, H. Albus, A. Dahan, and J. H. Meijer. ‘The opioid fentanyl affects light input, electrical activity and Per gene expression in the hamster suprachiasmatic nuclei’ Eur. J. Neurosci., 21: 2958-2966, 2005. F1000

42. M.Zueger, A. Urani, S. Chourbaji, C. Zacher, H.P. Lipp, U. Albrecht, R. Spanagel, D.P. Wolfer and P. Gass. ‘mPer1 and mPer2 mutant mice show regular spatial and contextual learning in standardized tests for hippocampus-dependent learning’. J. Neural Transm., 113: 347-356 , 2006.

43. S.A. Brown, F. Fleury-Olela, E. Nagoshi, C. Hauser, C. Juge, C.A. Meier, R. Chicheportiche, J.-M. Dayer, U. Albrecht, U. Schibler. ‘The period length of fibroblast circadian gene expression varies widely among human individuals’ PLoS Biol., 3 (10), e338, 2005.

44. C. Cajochen, C. Jud, M. Münch, S. Kobialka, A. Wirz-Justice, U. Albrecht. “Evening exposure to blue light stimulates the expression of the clock gene PER2 in humans”. Eur. J. Neurosci., 23: 1082-1086, 2006.

45. C. Jud and U. Albrecht. “Circadian rhythms in murine pups develop in absence of a functional maternal circadian clock”. J. Biol. Rhythms, 21, 149-154, 2006.

46. R. Dallmann, C. Touma, R. Palme, U. Albrecht, S. Steinlechner. “Impaired daily glucocorticoid rhythm in Per1Brd and Per2Brd mice”. J. Comp. Physiol. A, 192, 769-775, 2006.

47. D. Abraham, R. Dallmann, S. Steinlechner, U. Albrecht, G. Eichele, H. Oster. “Restoration of circadian rhythmicity in circadian clock deficient mice in constant light”. J. Biol. Rhythms, 21, 169-176, 2006.

48. S.V. Yelamanchili, G. Pendyala, I. Brunk, M. Darna, U. Albrecht and G. Ahnert-Hilger. “Differential sorting of the vesicular glutamate transporter 1 into a defined vesicular pool is regulated by light signaling involving the clock gene Period 2”. J. Biol. Chem., 281: 15671-15679, 2006. F1000

49. C.A. Feillet, J. Ripperger, M.C. Magnone, A. Dulloo, U. Albrecht and E. Challet. “Lack of food anticipation in Per2 mutant mice”. Curr. Biol., 16, 2016-2022, 2006. Commented in Nat. Rev. Neurosci. 7, 908, 2006 F1000

50. T. Zghoul, C. Abarca, C. Sanchis-Segura, U. Albrecht, G. Schumann, R. Spanagel. “Ethanol Self-Administration and Reinstatement of Ethanol-Seeking Behavior in Per1Brdm1

Mutant Mice”. Psychopharmacology, 190, 13-19, 2007.

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51. M.A. Farré-Castany, B. Schwaller, P. Gregory, J. Barski, C. Mariethoz, J. Erikson, I.V. Tetko, D. Wolfer, I. Schmutz, U. Albrecht and A. E. P. Villa. “Differences in locomotor behavior revealed in mice deficient for the calcium-binding proteins parvalbumin, calbindin-D28k or both.” Behav. Brain Res., 178, 250-261, 2007.

52. H. Viswambharan, J. M. Carvas, V. Antic, A. Marecic, C. Jud, C. Zaugg, X.-F.Ming, J.-P. Montani, U. Albrecht and Z. Yang. “Disruption of the circadian Per2 gene alters vascular endothelial function”. Circulation, 115, 2188-2195, 2007.

53. X. M. Li, B. Claustrat, M. H. Hastings, U. Albrecht, F. Levi. “Interactions between clock gene mutation, circadian phenotype and tumor growth in mice”. Pathol. Biol. (Paris), 55, 194-197, 2007.

54. C.A. Feillet, J. Mendoza, U. Albrecht, P. Pevet, E. Challet. “Forebrain oscillators ticking with different clock hands”. Mol. Cell. Neurosci., 37, 209-221, 2008.

55. G. Hampp, J. A. Ripperger, T. Houben, I. Schmutz, C. Blex, S. Perrau-Lenz, I. Brunk, R. Spanagel, G. Ahnert-Hilger, J. Meijer, U. Albrecht. “Regulation of the murine monoamine oxidase A gene by circadian clock components implies clock influence on mood”. Curr. Biol., 18, 678-683, 2008. Commented in Science, 320, 719, 2008 F1000

56. S. Langmesser, T. Tallone, A. Bordon, S. Rusconi, U. Albrecht. “Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK”. BMC Mol. Biol., 9: 41, 2008. Highly accessed

57. J. Zhang, Z. Fang, C. Jud, M. J. Vansteensel, K. Kaasik, C. C. Lee, U. Albrecht, F. Tamanini, J. H. Meijer, B. A. Oostra, D. L. Nelson. “Fragile X related proteins regulate mammalian circadian behavioral rhythms”. Am. J. Hum. Genet., 83: 43-52, 2008.

58. S. Langmesser, P. Franken, S. Feil, Y. Emmenegger, U. Albrecht and R. Feil. “cGMP-dependent protein kinase type I is implicated in the regulation of the timing and quality of sleep and wakefulness”. PLoS One, 4: 1, e4238, 2009.

59. M. Darna, I. Schmutz, K. Richter, S. V. Yelamanchili, G. Pendyala, M. Höltje, U. Albrecht, and G. Ahnert-Hilger. “Time-of-day dependent sorting of vesicular glutamate transporter to the plasma membrane”. J. Biol. Chem., 284, 4300-4307, 2009.

60. L. Borgs, P. Beukelaers, R. Vandenbosch, L. Nguyen, G. Moonen, P. Maquet, U. Albrecht, S. Belachew and B. Malgrange. “Period 2 regulates neural stem/progenitor cell proliferation in the adult hippocampus”. BMC Neurosci., 10: 30, 2009. Highly accessed

61. C. Jud, S. Chappuis, V. L.Revell, T. L. Sletten, D.-J. Saaltink, C. Cajochen, D. J. Skeene and U. Albrecht. “Age-dependent alterations in human PER2 levels after early morning blue light exposure”. Chronobiol. Int., 26: 1462-1469, 2009.

62. F. Stadler, I. Schmutz, B. Schwaller and U. Albrecht. “Lack of calbindin-D28K alters response of the murine circadian clock to light”. Chronobiol. Int., 27: 68-82, 2010.

63. I. Schmutz, J.A. Ripperger, S. Baeriswyl-Aebischer and U. Albrecht. "The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors". Genes Dev., 24: 345-357, 2010. F1000

64. A. Vukolic, V. Antic, B. Van Vliet, Z. Yang, U. Albrecht, and J.-P. Montani."Role of Mutation of the Circadian Clock Gene Per2 in Cardiovascular Circadian Rhythms". Am. J. Physiol. Regul. Integr. Comp. Physiol., 298: R627-R634, 2010.

65. J. Mendoza, U. Albrecht, E. Challet. "Behavioral food-anticipation in clock gene deficient mice: confirming old phenotypes, describing new phenotypes". Genes Brain Behav., 9: 467-77, 2010.

66. A. Dollet, U. Albrecht, H. M. Cooper, O. Dkhissi-Benyahya. "Cones are required for normal temporal responses to light of phase shifts and clock gene expression". Chronobiol Int., 27: 768-781, 2010.

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67. E. Maronde, A. Schilling, S. Seitz, T. Schinke, I. Schmutz, G. van der Horst, M. Amling and U. Albrecht. "The clock genes Period 2 and Cryptochrome 2 differentially balance bone formation". PLoS One, 5: 7, e11527, 2010.

68. C. Jud, A. Hayoz and U. Albrecht. "High amplitude phase resetting in Rev-erbα/Per1 double mutant mice". PLoS One, 5: 9, e12540, 2010.

69. S. Daan, K. Spoelstra, U. Albrecht, I. Schmutz, M. Daan, B. Daan, F. Rienks, I. Poletaeva, G. dell'Omo, A. Vyssotski, H.-P. Lipp. "Lab mice in the field: unorthodox daily activity and effects of a dysfunctional circadian clock allele." J. Biol. Rhythms, 26: 118-129, 2011. F1000

70. L. Dong, A. Bilbao, M. Laucht, R. Henriksson, T. Yakovleva, M. Ridinger, S. Desrivieres, T. Clark, A. Lourdusamy, M.N. Smolka, S. Cichon, D. Blomeyer, J. Treutlein, S. Perreau-Lenz, S. Witt, F. Leonardi-Essmann, N. Wodarz, P. Zill, M. Soyka, U. Albrecht, M. Rietschel, M. Lathrop, G. Bakalkin, R. Spanagel, G. Schumann. "The circadian rhythm gene Period1 is associated with psychological stress-induced alcohol drinking". Am. J. Psychiatry, 168: 1090-1098, 2011.

71. I. Schmutz, S. Wendt, A. Schnell, A. Kramer, I. M. Mansuy, U. Albrecht. "Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock". PLoS One, 6: 6, e21325, 2011.

72. P. Janich, G. Pascual, A. Merlos, E. Batlle, J. Ripperger, U. Albrecht, H.M. Cheng, K. Obrietan, L. Di Croce, and S. Aznar Benitah. "The circadian molecular clock creates epidermal stem cell heterogeneity". Nature, 480: 209-214, 2011. F1000

73. D. Jeyaraj, S.M. Haldar, X. Wan, M.D. McCauley, J.A. Ripperger, K. Hu, Y. Lu, B.L. Eapen, N. Sharma, E. Ficker, M.J. Cutler, J. Gulick, A. Sanbe, J. Robbins, S. Demolombe, R.V. Kondratov, S.A. Shea, U. Albrecht, X.H.T. Wehrens, D.S. Rosenbaum, M.K. Jain. "Circadian rhythms govern cardiac repolarization and arrhythmogenesis". Nature, 483: 96-99, 2012. F1000

74. D. Jeyaraj, F.A.J.L. Scheer, J.A. Ripperger, S.M. Haldar, Y.Lu, D.A. Prosdocimo, S.J. Eapen, Y. Cui, G.H. Mahabeleshwar, G. Casadesus, E.M. Mintz, H. Sun, Y. Wang, K.M. Ramsey, J. Bass, S.A. Shea, U. Albrecht, M.K. Jain. "Circadian clock regulation of mammalian nitrogen homeostasis". Cell Metabol., 15: 311-323, 2012.

75. J.M. Carvas, A. Vukolic, G. Yepuri, Y. Xiong, K. Popp, I. Schmutz, S. Chappuis, U. Albrecht, X.F. Ming, J.P. Montani, Z. Yang. “Period2 gene mutant mice show compromised insulin-mediated endothelial nitric oxide release and altered glucose homeostasis”. Front. Physiol., 3: 337, 2012.

76. E. Kowalska, J.A. Ripperger, D.C. Hoegger, P. Bruegger, T. Buch, T. Birchler, A. Mueller, U. Albrecht, C. Contaldo, S.A. Brown. “NONO couples the circadian clock to the cell cycle”. Proc. Natl. Acad. Sci. USA, 110: 1592-1599, 2013. F1000

77. A. Erzberger, G. Hampp, A. Granada, U. Albrecht, H. Herzel. “Genetic redundancy strengthens the circadian clock leading to a narrow entrainment range”. J. R. Soc. Interface, 10: 20130221, 2013.

78. S. Chappuis, J.A. Ripperger, A. Schnell, G. Rando, C. Jud, W. Wahli, U. Albrecht. “Role of the circadian clock gene Per2 in adaptation to cold temperature”. Mol. Metab., 2: 184-193, 2013.

79. F. Zani, L. Breasson, B. Becattini, A. Vukolic, J.P. Montani, U. Albrecht, A. Provenzani, J.A. Ripperger and G. Solinas. “PER2 promotes glucose storage to liver glycogen during feeding and acute fasting by inducing Gys2, PTG and GL expression”. Mol. Metab., 2: 292-305, 2013.

80. M. Aramendy, S. Seibert, P. Treppmann, K. Richter, G. Ahnert-Hilger and U. Albrecht. “Synaptophysin is involved in resetting of the mammalian circadian clock”. J. Circ. Rhythms, 11: 11, 2013.

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81. A. Schnell, S. Chappuis, I. Schmutz, E. Brai, J.A. Ripperger, O. Schaad, H. Welzl, P. Descombes, L. Alberi and U. Albrecht. "The nuclear receptor REV-ERBα regulates Fabp7 and modulates adult hippocampal neurogenesis". PLoS One, 9: 6, e99883, 2014.

82. I. Schmutz, R. Chavan, J.A. Ripperger, E.S. Maywood, N. Langwieser, A. Jurik, A. Stauffer, J.E. Delorme, S. Moosmang, M.H. Hastings, F. Hofmann and U. Albrecht. "A specific role for the REV-ERBa controlled L-type voltage gated calcium channel Cav1.2 in resetting the circadian clock in the late night". J. Biol. Rhythms, 29: 288-298, 2014.

83. M.C. Magnone, S. Langmesser, A. Bezdek, T. Tallone, S. Rusconi, and U. Albrecht. “The mammalian circadian clock gene Per2 modulates cell death in response to oxidative stress”. Front. Neurol., 5: 289, 2015.

84. L. Bee, S. Marini, G. Pontarin, P. Ferraro, R. Costa, U. Albrecht and L. Celotti. “Nucleotide excision repair efficiency in quiescent human fibroblasts is under control of the circadian clock”. Nucl. Acids. Res., in press, 2015.

Reviews 1. U. Albrecht “Circadian rhythms: A fine c(l)ocktail”. Curr. Biol., 11, R517-R519, 2001 2. U. Albrecht “Regulation of mammalian circadian clock genes”. J. Appl. Physiol., 92, 1348-

1355, 2002 3. H. Oster, E. Maronde, U. Albrecht. "The circadian clock as a calendar?". Chronobiol. Int., 19,

507-516, 2002 4. D. Holzberg and U. Albrecht. "The circadian clock: A manager of biochemical processes

within the organism". J. Neuroendocrinol., 15, 339-343, 2003. 5. U. Albrecht and G. Eichele. “The circadian clock”. Curr. Opin. Gen. Dev., 13, 271-277, 2003 6. U. Albrecht “Molecular basis of circadian rhythm and behavior” Neuroendocrinol. Lett., 24

(Suppl 1), 188-191, 2003. 7. U. Albrecht “The mammalian circadian clock: a network of gene expression”. Front. Biosci., 9,

48-55, 2004. 8. U. Albrecht “Human molecular chronotyping in sight?”. Genome Biol., 5, 246, 2004. 9. G. Pendyala and U. Albrecht. “Circadian rhythms, glutamate and behavior”. Proc. Indian Natl.

Sci. Acad., B71, 207-218. 10. S. Langmesser and U. Albrecht “Life time – circadian clocks, mitochondria and metabolism”

Chronobiol. Int., 23: 151-157, 2006. 11. U. Albrecht “Molecular orchestration of the hepatic circadian symphony”. Genome Biol., 7,

234, 2006. 12. C.A. Feillet, U. Albrecht and E. Challet . “Feeding time for the brain : a matter of clocks”. J.

Physiol. (Paris), 100, 252-260, 2006. 13. U. Albrecht “Orchestration of Gene Expression and Physiology by the Circadian Clock”. J.

Physiol. (Paris), 100, 243-251, 2006. 14. U. Albrecht, A. Bordon, I. Schmutz and J. Ripperger. “The multiple facets of Per2”. Cold

Spring Harbor Symposia on Quantitative Biology, Volume 72, 95-104, 2007. 15. C. Dibner, U. Schibler and U. Albrecht. "The mammalian circadian timing system:

organization and coordination of central and peripheral clocks". Annu. Rev. Physiol., 72, 517-549, 2010.

16. U. Albrecht. "Circadian clocks in mood related behaviors". Ann. Med., 42, 241-251, 2010. 17. J.A. Ripperger, C. Jud and U. Albrecht. "The daily rhythm of mice". FEBS Lett., 585, 1384-

1392, 2011. 18. U. Albrecht. "The Circadian Clock, Reward and Memory". Front. Mol. Neurosci., 4: 41, 2011.

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19. I. Schmutz, U. Albrecht and J. Ripperger. "The role of clock genes and rhythmicity in the liver". Mol. Cell. Endocrinol., 349, 38-44, 2012.

20. U. Albrecht. "Circadian Rhythms and Sleep - The Metabolic Connection". Pflugers Arch. - Eur. J. Physiol., 463, 23-30, 2012.

21. U. Albrecht. “Timing to perfection: The biology of central and peripheral circadian clocks”. Neuron, 74, 246-260, 2012.

22. A. Schnell, U. Albrecht and F. Sandrelli. "Rhythm and Mood: Relationship Between the Circadian Clock and Mood-Related Behavior". Behav. Neurosci., 128: 326-343, 2014.

Comments 1. U. Albrecht News & Views: “Per2 has time on its side”. Nat. Chem. Biol., 3, 139-140, 2007. 2. G. Hampp and U. Albrecht. “The circadian clock and mood-related behavior”. Comm. Int.

Biol., 1, 1-3, 2008. 3. R. Feil, S. M. Hölter, K. Weindl, W. Wurst, S. Langmesser, A. Gerling, S. Feil and U.

Albrecht. “cGMP-dependent protein kinase I, the circadian clock, sleep and learning”. Comm. Int. Biol., 2, 4, 2009.

4. J. Ripperger, I. Schmutz and U. Albrecht. "PERsuading nuclear receptors to dance the circadian rhythm". Cell Cycle, 9, 2515-2521, 2010.

5. J.A. Ripperger and U. Albrecht. “REV-ERB-erating nuclear receptor functions in circadian metabolism and physiology”. Cell Research, 22: 1319-1321, 2012.

Methods and Book chapters 1. U. Albrecht, G. Eichele, J.A. Helms and H.-C. Lu. “Visualization of gene expression patterns

by in situ hybridization”. In: Molecular and Cellular Methods in Developmental Toxicology, Ed. G.P. Daston, CRC Press Inc., Boca Raton, pp. 23-48, 1997.

2. U. Albrecht, H.-C. Lu, J. P. Revelli, X.-C. Xu, R. Lotan and G.Eichele. “Studying gene expression on tissue sections using in situ hybridization”. In: Human Genome Methods, Ed. K.W. Adolph, CRC Press Inc., Boca Raton, 93-120, 1998.

3. U. Albrecht and R.G. Foster. "Placing ocular mutants into a functional context: a chronobiological approach". Methods, 28, 465-477, 2002.

4. C. Jud, I. Schmutz, G. Hampp, H. Oster and U. Albrecht. “A guideline for analyzing circadian wheel-running behavior in rodents under different lighting conditions”. Biol. Proced. Online, 7, 101-116, 2005.

5. U. Albrecht and J. A. Ripperger. Clock Genes. In: Binder, M.D, Hirokawa, N, Windhorst, U (eds). Encyclopedia of Neuroscience. Springer, Berlin Heidelberg New York, Part 3, pp 759-762, 2009.

6. J. A. Ripperger and U. Albrecht. Clock-Controlled Genes. In: Binder, M.D, Hirokawa, N, Windhorst, U (eds). Encyclopedia of Neuroscience. Springer, Berlin Heidelberg New York, Part 3, pp 752-757, 2009.

7. C.A. Feillet and U. Albrecht. "Clocks, Brain Function and Dysfunction" in The Circadian Clock, U. Albrecht (Ed.), Springer, Berlin, Heidelberg, New York, Protein Reviews Series, Volume 12, 229-282, 2010.

8. J. A. Ripperger and U. Albrecht. “The circadian clock component PERIOD2: From molecular to cerebral functions”. Eds. A. Kalsbeek, M. Merrow, T. Roenneberg and R.G. Foster. Prog. Brain Res., 199, 233-245, 2012.

9. U. Albrecht. “Circadian clocks and mood related behaviors”. Handbook of Exp. Pharmacol 217, 227-239, 2013.

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10. U. Albrecht. "Circadian clock, reward and addictive behavior". In: Circadian Medicine. Whiley and Sons Inc., in press, 2014.

Book Edited U. Albrecht (Editor), The Circadian Clock, Springer Berlin, Heidelberg, New York, Protein Reviews Series, Volume 12, 2010 ISBN: 978-1-4419-1261-9. Tutorials 1. U. Albrecht “Oszillierenden Systemen auf der Spur: Molekulare Zahnräder der inneren Uhr”.

MedReport, Organ für ärztliche Fortbildungskongresse, Nr. 25 / 25. Jahrgang, Blackwell Wissenschaft, Berlin, August 2001

2. U. Albrecht "Die innere Uhr: Gene und Verhalten". Bull. Soc. Frib. Sc. Nat., 91, 65-72, 2002 3. U. Albrecht Gazette des Anciens AAEMUF, Numero 8, Septembre 2005 4. U. Albrecht Unsere innere Uhr, Vitaswiss Magazin bisch zwäg, 98. Jg., 12-15, Mai 2006 5. S. Langmesser and U. Albrecht “Circadian clocks – it’s all about energy”, Bioforum, 11, 7-8,

pp 30-31, 2007. 6. U. Albrecht "Wenn die innere Uhr aus dem Lot gerät", Universitas, Dezember 2011, 02. 7. U. Albrecht “Light, circadian clocks and cancer”, Jahresbericht Universität Fribourg, 2011. 8. U. Albrecht “Hat die Umstellung auf Winterzeit oder Sommerzeit einen Einfluss auf unsere

innere Uhr?”, Unireflets 2, November 2012. Interview: Interview by Catherine Cormier on www.scivee.tv