CURRICULUM VITAE Mary Sharon Stack, Ph.D.

Current Address: Director, Harper Cancer Research Institute Professor of Chemistry and Biochemistry University of Notre Dame Harper Cancer Research Institute A200D Harper Hall Notre Dame, IN 46556 574-631-2518 sstack@nd.edu www.stackscientific.com Current Position: Professor of Chemistry and Biochemistry Ann F. Dunne & Elizabeth Riley Director, Harper Cancer Research Institute Education: Bachelor of Science, Biochemistry (l981) - Clemson University, Clemson, SC Fulbright Scholar (1982/3) - Universität Bonn, Bonn, Federal Republic of Germany - Molecular Mechanisms of Biomineralization. G. Krampitz, Ph.D., advisor. Master of Science, Biomedical Sciences/Biochemistry (1985) - East Tennessee State University, Johnson

City, TN; Master’s Thesis: Effects of Ozone on Alpha-1-Proteinase Inhibitor and Alpha-1- Antichymotrypsin Structure and Function: Evidence for Free Radical Involvement. D.A. Johnson Ph.D., thesis advisor

Doctor of Philosophy, Biochemistry (1989) - University of Louisville, Louisville, KY; Doctoral Dissertation: Purification   and   Kinetic   Comparison   of   Synovial   Collagenase   and   Gelatinase. R.D. Gray Ph.D., dissertation advisor

Post-Doctoral Research Associate (1989-91) - Duke University Medical Center, Durham, NC, Department of Pathology, laboratory of S. V. Pizzo, M.D./Ph.D.

Honors and Affiliations: 1978 Alpha Lambda Delta National Freshman Honor Society, Clemson University 1978-80 Delta Phi Alpha National German Honor Society, Clemson University 1980 Badische Award for Distinguished Achievement in German, Clemson University 1982-83 Fulbright Scholarship for Graduate Study Abroad, Bonn, West Germany 1984- Sigma Xi, Scientific Research Society 1985-89 University Fellow, University of Louisville 1989 Graduate Dean’s Citation, University of Louisville 1995 - American Association for Cancer Research 1995 - American Society for Biochemistry and Molecular Biology 1997 - American Association for the Advancement of Science 1999 - International Proteolysis Society (Council Member, 11/01-10/05) 2001 - American Society for Matrix Biology 2002- Metastasis Research Society 2008-11 Mulligan Endowed Professor of Cancer Research, University of Missouri

2011-12 Ann F. Dunne and Elizabeth Riley Science Director, Harper Cancer Research Institute 2012 Fellow of the American Association for the Advancement of Science 2013- Ann F. Dunne and Elizabeth Riley Director, Harper Cancer Research Institute 2013 Vice-Chair of Matrix Metalloproteinases Gordon Research Conference, Il Ciocco, Italy 2014 Provost’s Faculty Recognition Award, September 2014 2015 Chair of Matrix Metalloproteinases Gordon Research Conference, Newry, ME Professional Experience: 1981 Laboratory Technician, Department of Microbiology, Clemson University, Clemson, SC 1984 Laboratory Research Assistant, Department of Biochemistry, East Tennessee State University,

Johnson City, TN 1985 Teaching Assistant, Department of Biochemistry, University of Louisville, Louisville,KY 1987 Instructor, Natural Sciences Department, Indiana University Southeast, New Albany, IN 1989 Post-Doctoral Research Associate, Department of Pathology, Duke University Medical Center,

Durham, NC, (laboratory of S.V. Pizzo) April 1989 - July 1991 1991 Assistant Research Professor, Department of Pathology, Duke University Medical Center,

Durham, NC, August 1991 - September 1994 1994 Assistant Professor, Department of Obstetrics and Gynecology, Division of Gynecologic

Oncology, Northwestern University Medical School, Chicago, IL, October 1994-August 2000 1994 Adjunct Assistant Professor, Department of Cell and Molecular Biology, Northwestern

University Medical School, Chicago, IL, October 1994- August 2000 2000 Associate Professor, Department of Obstetrics and Gynecology, Northwestern University

Medical School, Chicago, IL 2000 Adjunct Associate Professor, Department of Cell and Molecular Biology, Northwestern

University Medical School, Chicago, IL 2001 Associate Professor (tenure), Department of Cell and Molecular Biology, Northwestern

University Medical School, Chicago, IL 2001 Adjunct Associate Professor, Department of Obstetrics and Gynecology, Northwestern University

Medical School, Chicago, IL 2006 Professor, Department of Cell and Molecular Biology, Northwestern University Feinberg Medical

School, Chicago, IL 2007 Professor and Vice-Chair for Research, Department of Pathology and Anatomical Sciences,

University of Missouri School of Medicine, Columbia, MO 2007 Adjunct Professor of Medical Pharmacology and Physiology, University of Missouri School of

Medicine, Columbia, MO 2007-‘10 Adjunct Professor of Cell and Molecular Biology, Northwestern University Feinberg Medical

School, Chicago, IL 2011 Professor of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 2011-‘12 Science Director, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN 2011-‘14 Adjunct Professor of Pathology and Anatomical Sciences, University of Missouri School of

Medicine, Columbia, MO 2012 Adjunct Professor, Indiana University School of Medicine, Indianapolis, IN 2013- Director, Harper Cancer Research Institute

Grant  Review  Service:    National  Research  Mentoring  Network  (NMRN)  Pilot  Award  Review  Panel  -­‐  (NMRN  funds  projects  to     enhance  the  training  and  career  development  of  underrepresented  individuals),  05/15  Department   of   Defense   Ovarian   Cancer   Research   Program   Integration   Panel   -­‐   Gynecologic   Cancer  Center  of     Excellence  Programmatic  Review  -­‐  03/15  National Institutes of Dental and Craniofacial Research Special Emphasis Panel ZDE1 U01 Grant Review Panel 11/14 National Institutes of Health, Tumor Progression and Metastasis Study Section, AdHoc reviewer 03/14 Department of Defense Ovarian Cancer Research Program Integration Panel, 2012-2015 Department of Defense Ovarian Cancer Research Program Vision Setting Panel, 2012-2014 National Institute of Dental and Craniofacial Research DSR Study Section, June 2012; June 2013 National Institute of Biomedical Imaging and Bioengineering Conference Grant Review Panel, July 2013 National Institutes of Health, Research Answers to NCI’s Provocative Questions review panel, ZCA1-SRLB- D; ZCA1-SRLB-9, 2012 Rivkin Foundation for Ovarian Cancer Research, 2008-2011 National Institutes of Health, Tumor Progression and Metastasis Study Section, AdHoc reviewer 02/08 National Institutes of Health, Tumor Microenvironment Study Section, AdHoc reviewer 10/07 Marsha Rivkin Center for Ovarian Cancer Research, Reviewer, 2007 - 2011 National Institutes of Health, Member Tumor Progression and Metastasis Study Section (TPM, formerly

Pathology B), 2003-2006 National Institutes of Health, Member Pathology B Study Section 2002-‘03, (Ad Hoc 2000-1) National Institute of Dental and Craniofacial Research Special Study Section on Proteomics in Head & Neck

Cancer, Special Emphasis Panels, 2003-7 National Institutes of Health/National Cancer Institute Program Project Review Panels, 1995-2002 National Institutes of Health, Ad Hoc Reviewer (R13 grants), 1996 - 1997 National Institutes of Health, Ad Hoc Reviewer, Lung Biology and Pathology Study Section, 1999 National Institutes of Health, Ad Hoc Reviewer, Metabolic Pathology Study Section, 1999 U.S. Army Medical Research and Materiel Command Breast Cancer Research Program (Department of

Defense); Cell &Tissue Biology and Pathobiology Review Panels; 1994-2004, 2008-8 U.S. Army Medical Research and Materiel Command (Department of Defense) Prostate Cancer Research

Program; Pathobiology Review Panel, 1998-2004 U.S. Army Medical Research and Materiel Command (Department of Defense) Ovarian Cancer Research

Program; Cell Biology Review Panel, 1998-2005 U.S. Army Medical Research and Materiel Command Breast Cancer Research Program Knowledge Harvest;

Subject Matter Expert, 1998-1999 National Science Foundation, Ad Hoc Reviewer in Molecular Biochemistry, March, 1995 International Human Frontier Science Program, Reviewer, 1995 - 2000 Breast Cancer Research Program, Univ. of California, Tumor Biology and Pathogenesis Study Sections,

1996-2002; 2005-8 Israel Science Foundation, Reviewer, 1997, 2002 Veterans Administration Career Development Award Reviewer, 1999-2000 U.S. Civilian Research and Development Foundation for the Independent States of the Former Soviet Union

(funded by US State Dept., NIH and NSF), Reviewer, 2000 Natural Sciences and Engineering Research Council of Canada (NSERC) and the Canadian Institutes of

Health Research (CIHR) Collaborative Health Research Projects (CHRP) Program grant reviewer, 2010 Journal Review Service:

Editorial Boards: Cancer Research, 2001 – present Journal of Biological Chemistry, 2003 - 2008 Biochemical Journal, 2005 - 2011 Current Drug Targets, 2013 - present

Reviewer: Nature, Journal of Biological Chemistry, Biochemistry, Biochemical Journal, Cancer Research, Clinical Cancer Research, Journal of Cell Biology, Journal of Cell Science, International Journal of Cancer, Biochemica et Biophysica Acta, Journal of the National Cancer Institute, Journal of Cellular Physiology, Journal of Pathology, Journal of Dental Research, Clinical and Experimental Metastasis, Matrix Biology, Gynecologic Oncology, American Journal of Pathology, Cancer Detection and Prevention, International Journal of Biochemistry and Cell Biology, Gene, Connective Tissue Research, American Journal of Obstetrics and Gynecology, Oncogene, Science Translational Medicine, Journal of Microscopy Other Service: Board Member - RiverBend Cancer Services, South Bend, IN, 2014 - present Board Member - Northern Indiana Cancer Research Consortium, Mishawaka, IN, 2014 - present Department of Defense Ovarian Cancer Research Program Integration Panel, 2012-2015 Department of Defense Ovarian Cancer Research Program Vision Setting Panel, 2012-2014 Internal Advisory Board Member, Indiana University Simon Cancer Center, 2013 - present External Advisory Board - “Prostate Cancer Bone Metastasis: Biology and Targeting”, PO1 CA098912,

Leland Chung, Principal Investigator, Cedars-Sinai Medical Center, Los Angeles, CA, 2013 - present External Advisory Board - Karmanos Cancer Institute and the Meyer L. Prentis Comprehensive Cancer

Center at Wayne State University, 2003 - present International Scientific Committee, VIIIth International Workshop on the Molecular and Cellular Biology of

Plasminogen Activation, Jackson Hole, WY, Sept. 2001 Scientific Advisory Board, Angiomics Corp., Research Triangle Park, NC, 2000-2002 National Cancer Institute Gynocologic Oncology Program - Progress Review Group, June 2001 External Advisory Board - Walther Cancer Research Center, University of Notre Dame - 2000 International Proteolysis Society - elected to Council November 2001 - November 2005 American Association for Cancer Research Special Conference on Proteolysis, Extracellular Matrix and

Cancer (Oct. 2002, Hilton Head, SC) - Organizing Committee Current Research Grant Support: National Institutes of Health Research Grant R01 CA086984, “Regulation of Ovarian Cancer

Proteinases”; M. Sharon Stack, Principal Investigator. July 2005 - June 2015 National Cancer Institute RO1 CA109545, “Receptor Cross-Talk in Early Ovarian Cancer Metastatic

Dissemination”, M. Sharon Stack, Principal Investigator. July 2007 - May 2016 Walther Cancer Foundation/Harper Cancer Research Institute Advancing Basic Cancer (ABC) Research

Grant II “Nanomembrane-Based Nucleic Acid Sensing for Simultaneous Detection of Human Papillomavirus (HPV) and HPV-Induced MicroRNAs in Oropharyngeal Cancers” HC Chang, Principal Investigator, M. Sharon Stack Co-Investigator. July 2012 - June 2014 ($200,000 DC)

Leo and Anne Albert Charitable Trust, “Microenvironmental Regulation of Epithelial Ovarian Cancer Metastatic Success”, M. Sharon Stack, Principal Investigator. October 2013 - Sept 2016. ($450,000 DC)

Loyola-Notre Dame Research Collaboration, “Macrophage Stimulating Protein Ligand/RON Pathway is a Potential Therapeutic Target in Ovarian Cancer”, Maureen Drakes, Principal Investigator, M. Sharon Stack, Co-Investigator. October 2013- October 2014 ($50,000 DC)

National Institutes of Health/National Center for Advancing Translational Sciences UL1 TR001108, “Indiana Clinical and Translational Sciences Institute (CTSI), A. Shekhar, Principal Investigator. M. Sharon Stack, Co-Investigator: Director of CTSI TL1 Postodoctoral Training Program (5% effort). September 2013 - April 2018.

National Institutes of Health/National Center for Advancing Translational Sciences UL1 TR001108, “Indiana Clinical and Translational Sciences Institute (CTSI), A. Shekhar, Principal Investigator. M. Sharon Stack, Co-Investigator: Project Development Team (10% effort). September 2013 - April 2018.

Institutional Grant Support (for Harper Cancer Research Institute): Walther Cancer Foundation “Director’s Award” 2010 ($50,000) (used to purchase tissue microarrayer for

HCRI Tissue Biorepository) Walther Cancer Foundation “Director’s Award” 2011 ($50,000) (used to support Aperio Scanscope in HCRI

Tissue Biorepository) Walther Cancer Foundation “Director’s Award” 2012 ($50,000) (used to purchase laser for FACSARIA

facility) Walther Cancer Foundation “Director’s Award” 2013 ($50,000) (used to purchase centrifuge for Harper

Hall) Walther Cancer Foundation “Harper Cancer Research Institute Advancing Basic Cancer (ABC) Research

Grant” 2011-2013 ($400,000) Walther Cancer Foundation “Harper Cancer Research Institute Advancing Basic Cancer (ABC) Research

Grant II” 2012-2014 ($400,000) Walther Cancer Foundation “Harper Cancer Research Institute In Vivo Imaging Equipment Acquisition”

2012 ($189,000) Walther Cancer Foundation “Harper Cancer Research Institute Seeding Research in Cancer (Src) Pilot

Grants” 2012 ($180,000) Indiana Clinical Translational Science Institute Conference Grant for “Indiana-Illinois End Ovarian Cancer

Coalition (IIEEOCC)” June 2011 ($1500) Indiana University Simon Cancer Center, Tumor Microenvironment & Metastasis Program Conference

Grant for “Indiana-Illinois End Ovarian Cancer Coalition (IIEEOCC)” June 2011 ($1500) Walther Cancer Foundation “Harper Cancer Research Institute Advancing Basic Cancer Research Grant I

(ABC-I)” renewal 2013-2015 ($400,000) Walther Cancer Foundation “Global Partnerships for Discovery – Gene Expression Profiling of a Unique

Population of Breast Cancer Patients to Identify Novel Molecular Signatures” 2013 ($53,500) Walther Cancer Foundation “Harper Cancer Research Institute Biosample Repository: A Unique Tissue

Acquisition and Distribution Resource for Northern Indiana” 2013-2015 ($245,000) Walther Cancer Foundation “Simon-Harper Inter-Institutional Research Team (SHIRT) Grants” 2013

($200,000) Walther Cancer Foundation “The ENSCCII Training Project: Engineering Novel Solutions to Cancer’s

Challenges at the Inter-disciplinary Interface” 2013-2016 ($481,026) Walther Cancer Foundation “Harper Cancer Research Institute Campaign Support” 2013 ($36,898) St. Joseph’s Regional Medical Center “Seeding Research In Cancer (SRC)” Seed Grant 2012-2013; awarded

to Ryan Roeder for “Contrast-Enhanced X-Ray Detection of Breast Microcalcifications in a Murine Model of Radiographically Dense Mammary Tissue” ($25,000)

St. Joseph’s Regional Medical Center “Seeding Research in Cancer (SRC)” Seed Grant 2013-2014; awarded to Laurie Littlepage for “Gene Expression Profiling of a Unique Population of Breast Cancer Patients to Identify Novel Molecular Signatures in African-American Women” ($25,000)

Walther Cancer Foundation “Harper Cancer Research Institute Advancing Basic Cancer (ABC) Research Grant II” renewal 2014-2016 ($400,000)

Walther Cancer Foundation “The ENSCCII Training Project: Engineering Novel Solutions to Cancer’s Challenges at the Inter-disciplinary Interface -II” 2014-2017 ($487,932)

Walther Cancer Foundation “Harper Cancer Research Institute Seeding Research in Cancer (Src) Pilot Grants” 2014 ($100,000) (plus $40,000 cost share from College of Science and College of Engineering for a total of $140,000)

Walther Cancer Foundation “Mutational Evolution in Patients from Northern Indiana” 2014 ($71,245) - in collaboration with South Bend Medical Foundation

Walther Cancer Foundation “Fluorescence Microscopy for HCRI Tissue Biorepository” 2014 ($67,699) Walther Cancer Foundation “Global Partnerships for Discovery - II” 2014 ($50,000) - to support Dr. Laurie

Littlepage’s project on mutational profiling of Kenyan breast tumors Walther Cancer Foundation “Sequenom Mutational Profiling for Diagnostics, Biobanking and Research”

2014-2016 ($301,195 from WCF with $550,715 cost share from HCRI, South Bend Medical Foundation, St. Joseph Regional Medical Center, Memorial Hospital/Beacon) - to support clinical testing for cancer patients in the South Bend area, provide molecular barcoding for tissue bank, and enable research on mutational evolution

American Cancer Society IRG-126762 “Institutional Research Grant for Harper Cancer Research Institute” 2014-2017 ($300,000)

Pending Research Grant Support: National Institutes of Health RO1 (RO1DE025004) “Kallikreins, Cleavage and Cohesion in Oral Cancer”

M. Sharon Stack, Principal Investigator, April 2015 - March 2020. National Institutes of Health RO1 “A multiplexed, integrated microRNA screening platform for HPV-

associated oral cancer”, July 2015 - June 2020, HC Chang, Principal Investigator, M. Sharon Stack, Co-Investigator

Mentor on Trainee Grants: National Institutes of Health K08 CA94877, “Cadherin-Mediated Regulation of MMPs in Oral Cancer”,

H.G. Munshi, Principal Investigator; M. Sharon Stack, Mentor. September 2003 – August 2008. National Institutes of Health Research Supplements to Promote Diversity, RO1 CA86984-07S1, “Regulation

of Ovarian Cancer Proteinases” to support pre-doctoral training of Natalie M. Moss. M. Sharon Stack - Mentor. September 2007 – April 2010.

Illinois Department of Public Health/Penny Severns Breast, Cervical and Ovarian Cancer Research Fund Post-Doctoral Award “Epigenetic Regulation of Ovarian Cancer Metastasis”, Maria V. Barbolina, Principal Investigator; M. Sharon Stack, Mentor. September 2005 – June 2006.

Ovarian Cancer Research Foundation Program of Excellence Award “Epigenetic Regulation of Metastasis-Associated Gene Expression in EOC”, Maria V. Barbolina, Principal Investigator; M. Sharon Stack, Mentor. December 2006 – December 2007

Illinois Department of Public Health/Penny Severns Breast, Cervical and Ovarian Cancer Research Fund Post-Doctoral Award “Mechanisms of Invasion and Survival in Metastatic Ovarian Cancer”, Maria V. Barbolina, Principal Investigator; M. Sharon Stack, Mentor. July 2007 – June 2008.

National Institutes of Health Research Supplements to Promote Diversity, RO1CA086984-11S1 “Regulation of Ovarian Cancer Proteinases” to support pre-doctoral training of Rebecca J Burkhalter. M. Sharon Stack, Mentor. Oct. 2010 – Sept. 2013.

National Institutes of Health Ruth L. Kirschstein National Research Service Award for Individual Predoctoral Fellowship to Promote Diversity in Health-Related Research F31CA159804, Lana Bruney, pre-doctoral fellow “Integrin-Linked Kinase and Ovarian Cancer Metastasis”. M. Sharon Stack, Mentor, Sept. 2011 – March 2014.  

Indiana Careers at Notre Dame Summer Research Internship award, Matthew Metzinger, undergraduate student “Introduction to Cancer Research”. M. Sharon Stack, Mentor, June 2012 - Aug 2012.

National Institutes of Health Ruth L. Kirschstein National Research Service Award for Individual Pre- doctoral Fellowship F31 DE021926, Daniel Miller, pre-doctoral (MD/PhD) fellow “MicroRNA Profiling and Tumor Progression in HPV+ Oropharyngeal Cancer”. M. Sharon Stack, Mentor, July 2011 - June 2014. National Science Foundation Graduate Research Fellowship Program DGE1313583, Elizabeth Loughran, pre-doctoral fellow. M. Sharon Stack, Mentor. Sept. 2014 - Sept. 2017. Previous Research Grant Support: National Institutes of Health Individual National Research Service Award # 1F32 HL08382,

“Plasminogen Interactions with the Extracellular Matrix”, M. Sharon Stack, P.I., S.V. Pizzo, Mentor, Oct. l990 - Apr. l992

Armstrong Fellow in Cancer Research, Duke University Comprehensive Cancer Center, Sept. 1991-1992 National Institutes of Health Supplement to Duke University Cancer Center Core Grant #CA 14236,

“Matrix Regulation of Ovarian Carcinoma-Associated Proteinase Secretion and Activity”, M. Sharon Stack, P.I. Oct. 1992 - Sept. 1993

National Institutes of Health Shannon Award for Research Grant #CA58900, “Matrix Regulation of Metastasis-Associated Proteinases”, M. Sharon Stack, Principal Investigator. Oct. 1993- May 1993

National Institutes of Health Research Grant #RO1 CA58900, “Matrix Regulation of Metastasis-Associated Proteinases”, M. Sharon Stack, P.I. June 1994 - Sept. 1999

National Institutes of Health Research Grant #RO1 CA71875, “Plasminogen-Angiostatin Converting Enzyme”, G.A. Soff, Principal Investigator; M.S. Stack, Co-Investigator. Apr.1997- Mar. 2001

National Institute of Dental Research Oral Cancer Center Pilot Grant from #P50 CA11921, “Multifunctional Interaction of uPA/R and Integrins in Oral Cancer”, M.S. Stack, P.I. Dec. 1999 - Nov.2001

National Cancer Institute #U01 CA85133 “National Ovarian Cancer Early Detection Program”, D.A. Fishman, PI, M.S. Stack Co-Investigator. September 1999 - August 2004

National Institute of Dental Research Grant # PO1 DE12328, “Junctions, Cytoskeleton & Matrix of the Oral Epithelium”, J.C.R. Jones, Principal Investigator; M.S. Stack, Project 2 Leader. July 1997 - May 2007

National Institutes of Health Research Grant #R01 CA 86984, “Regulation of Ovarian Cancer Proteinases”; M.Sharon Stack, Principal Investigator. July 2000 - June 2005

National  Institutes  of  Health  Research  Grant  #  RO1  CA85870,  “  Interaction  of  uPA/R  and  Integrins  in  Oral  Cancer”,  M.  Sharo7n  Stack,  Principal    Investigator.    July  2001  -­‐  August  2005

National Institutes of Health "Research Supplement to Promote Diversity in Health-Related Research" awarded to 2RO1 CA86984 to support graduate training of Natalie M. Moss, July 2006 - April 2010.

National  Institutes  of  Health  Research  Grant  #RO1CA90492  “Contributions  of  Activated  EGF  Receptor  to  Ovarian  Cancer  Metastasis”,  Laurie  Hudson  -­‐  Principal  Investigator,  M.S.  Stack,  Co-­Investigator.    August  2002  -­‐  July  2007    

Mizzou Advantage Network Grant “Symposium and Faculty Workshop on Integrin Signaling in Physiology and Disease”, A. Chandrasekhar, Principal Investigator, M. Sharon Stack, Co-Investigator, April – Oct. 2010

National   Institutes  of  Health  Research  Grant  RO1  CA085870,  “   Interaction  of  uPA/R  and  Integrins   in  Oral  Cancer”,  M.  Sharon  Stack,  Principal    Investigator.  July  2001  -­‐  Feb  2013    

Indiana Clinical Translational Science Institute Core Pilot grant “A Murine Model of Early Events in Epithelial Ovarian Cancer Metastasis”, M. Sharon Stack, Principal Investigator, August 2012-July 2014 ($10,000 DC)

Patents    Jones,  J.C.R.,  Stack,  M.S.  and  Goldfinger,  L.E.  Methods  and  Materials  for  Making  and  Using  Laminin-­‐5,            US  6,294,356  B1  Moser,  T.L.,  Pizzo,  S.V.,  and  Stack,  Mary  S.    Angiostatin  Receptor,  US  6,444,431  B1 Stack, M.S. and Miller, D.L. MicroRNA profile characteristic of HPV-associated throat cancers.

Provisional patent #61/867,380; file date 8/19/2013. Stack, M.S. and Miller, D.L. Method and Composition for Detection of Oncogenic HPV. Serial number

PCT/US14/51692; file date 08/19/2014.

Local  Administrative  Experience  (Northwestern  University):  1.     Program   Leader,   R.H.   Lurie   Comprehensive   Cancer   Center   Basic   Science   Program   on   Tumor  Invasion,  Metastasis  and  Angiogenesis,  1999-­‐2007 2. Leadership Committee, R. H. Lurie Comprehensive Cancer Center, 9/99-01/07  3.   Subgroup   Leader   -­‐   Angiogenesis   Group;   R.H.   Lurie   Comprehensive   Cancer   Center   Basic   Science            Research  Division;  Adhesion,  Motility  and  Angiogenesis  Group;  9/97-­‐9/99  4.    Co-­‐Leader  Gynecologic  Oncology  Research  Program;  R.H.  Lurie  Comprehensive  Cancer  Center    ‘98-­‐00  5.    Organizer,  Gynecologic  Malignancies  Working  Group,  ‘97-­‐‘00  6.    Co-­‐Organizer,  Schweppe  Basic  Science  Colloquium  “The  Basic  Science  Underlying  Anti-­‐Angiogenic  Therapies”  5/98  7.    Co-­‐Chair,  Bea  Schriesheim  Ovarian  Cancer  Research  Symposium  "The  Power  of  New  Discoveries:    The  Pathway  for  Understanding  Ovarian  Cancer",  09/05  and  11/06.   Local Administrative Experience (University of Missouri): 1. Vice-Chair for Research, Department of Pathology & Anatomical Science (PAS), 01/07 - 05/2011 2. Organizer, Introduction to PAS Research Symposium, March 2007, May 2008 3. Organizer, Cell Adhesion Coalition seminar/discussion series, September 2007 – 2009 4. Co-Organizer, Integrin Signaling in Physiology and Disease symposium, October 2010, supported by a Mizzou Advantage Grant Local Administrative Experience (University of Notre Dame): 1. Ann F. Dunne and Elizabeth Riley Science Director, Harper Cancer Research Institute, 05/11 - 12/12 2. Ann F. Dune and Elizabeth Riley Director, Harper Cancer Research Institute, 01/13 - present 3. Internal Advisory Committee, Indiana University Simon Cancer Center 01/12 - 4. Co-Organizer Harper Cancer Research Institute Research Day poster session and symposium, April 2012

5. Organizer, inaugural meeting of Indiana-Illinois End Epithelial Ovarian Cancer Coalition workshop, 06/12 6. Co-Organizer Harper Cancer Research Institute Research Day poster session and symposium, April 2013 7. Co-Organizer Joint Loyola-Notre Dame Cancer Retreat, Chicago, IL, July 2013 8. Co-Organizer Walther Cancer Foundation Research Symposium, October 2013 9. Co-Organizer Joint MD Anderson Cancer Center-Notre Dame Collaboration Meeting, December 2013 10. Co-Organizer Joint Loyola-Notre Dame Cancer Retreat, South Bend, IN, April 2014 11. Co-Organizer Harper Cancer Research Institute Research Day poster session and symposium, April 2014 12. Co-Organizer, Second Indiana-Illinois End Epithelial Ovarian Cancer Coalition workshop, June 2014 13. Co-Organizer Joint MD Anderson Cancer Center-Notre Dame Collaboration Meeting, July 2014 Teaching Experience (Northwestern): A. Graduate/Post-Graduate: 1. Cell Biology - Extracellular Matrix 2.    Tumor  Cell  Biology  -­‐  Adhesion,  Proteolysis,  Invasion,  Metastasis  and  Angiogenesis 3. Carcinogenesis - Integrins, Proteinases, Metastasis, and Angiogenesis 4. Integrated Graduate Program Rotation Students:

Vy Do (‘95), Shawn Ellerbroek (‘97), Shane Oram (‘98), Yi Wu (‘99), Jennifer Sosnowski (‘00), Xiaoguang Guo (‘01), Jamie Symcowicz (‘02), Yvonne Wu (‘03), Natalie Moss (’05), Mike Rabin (’05)

5. Masters in Biotechnology Internship Students: Tom Kazmierczak (‘95), Zac Piper (‘96/97), Denny Sarlis (97/98) 5. Ph.D. Mentor: Timothy Young (‘91-‘95), Dissertation: “Proteolysis and Its Regulation in Ovarian Carcinoma”

Shawn Ellerbroek (‘97-‘00), Dissertation:“Regulation of Membrane Associated Matrix Metalloproteinases Involved in Ovarian Cancer Cell Metastasis: Role for Type I Collagen And Epidermal Growth Factor”

Yi Wu (‘99-’04), Dissertation: “Dynamic Regulation of Membrane Type 1 Matrix Metalloproteinase” Jaime Symcowicz (’02 - ‘07), Dissertation: “Microenvironment Regulation of Proteinase Expression

and E-Cadherin Ectodomain Generation in Ovarian Cancer” Natalie Moss (‘05-‘09), Dissertation:

6. Post-Doctoral Mentor: Supurna  Ghosh  (‘98-­‐‘03)  H.G.  Munshi  (‘00-­‐‘03)  Edgardo  Ariztia  (‘01-­‐‘03)  Subhendu  Mukhopadhyay (‘01-’04) Maria Barbolina (‘04-‘06) Zonggao Shi (’07-‘10)

7. External Examiner - University of New South Wales, Sydney, Australia, dissertation committee of Paul Stathakis (Phil Hogg, mentor)

B. Medical/Dental: 1. Dental Biochemistry - Connective Tissue and Biomineralization 2. Medical Student Research Elective: Susan Larsh (‘95), Amy Hegg (‘96)

3. Medical Student Research Program - Penny Matthews‘95, Danielle Wallace ‘00 4. Medical Scientist Training Program - Kara Gleason (’05) 5. Post-Doctoral Mentor H. G. Munshi, M.D. (Hematology/Oncology Research Fellow) (‘00-‘03) (Received KO8 award) 6. Medical Student Freshman Class - Structure/Function - Connective Tissue Histology ('05) C. Undergraduate

1. C99 Research Elective - Alicia Kearns (9/94-6/95), Honors Thesis won award from Northwestern Biology Department 2. CURE program mentor (Continuing Umbrella of Research Experience; summer internship training in research for minority undergraduates (yearly for summer session, ‘00-present)

 Teaching  Experience  (University  of  Missouri)        A.    Graduate/Post-­‐Graduate                  1.    Advanced  Oncology  (School  of  Veterinary  Medicine)                  2.    Rotation  Students                              Rebecca  Burkhalter  (MPP,  ’07);  Kim  Ingersoll  (MD/PhD,  ’10);  Daniel  Miller  (MD/PhD,  ’10)                  3.    Masters  in  Pathology  Students                            Rong  Jiang  (’08-­‐‘10);  Thesis:    “Role  of  Multiple  Kallikreins  (KLK5,  7,  8,  and  9)  in  Human  Oral             Squamous  Cell  Carcinoma”       Yuliya  Klymenko  (Fulbright  Fellow;  ’09-­‐‘11);  Thesis:        4.    Post-­‐Sophmore  Pathology  Fellows,  Research  Mentor:        Jason  Pettus  (’08);  Dan  Miller  (’10)                  5.    Ph.  D.  Mentor:        Rebecca  Burkhalter  (’08-­‐‘13,  Univ.  of  Missouri)  Research  Supplement  to  Promote  Diversity,             CA086984-­‐S1  2008  -­‐  2011.    Dissertation:  “Microenvironmental Regulation of Ovarian Cancer Dissemination Via Activation Of The Wnt Signaling Pathway”  

Lana  Bruney  (’09-­‐present,  Univ.  of  Missouri)    Individual  NRSA  F31CA159804  Integrin-­Linked         Kinase  and  Ovarian  Cancer  Metastasis,  2011  -­‐  2014;  Dissertation  title:    “Regulation  of           Adhesion  and  Proteolysis  in  Ovarian  Cancer”  

     6.    M.D./Ph.D.  Mentor    Daniel  Miller   (’10-­‐’14   (PhD),  Univ.   of  Missouri)   Individual  NRSA  F31  DE021926,   2011-­‐2013,     “MicroRNA  Profiling  and  Tumor  Progression   in  HPV+  Oropharyngeal  Cancer”.    Dissertation:       “Comprehensive  Profiling  of  MicroRNA  in  Squamous  Cell  Carcinoma  of  the  Head  and  Neck”  

Awards: 2014 Outstanding Graduate Student Teaching Award; Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine; 2014 - 1st place, team business plan competition (NanDio a microRNA based diagnostic platform for oropharyngeal carcinomas), Cardinal Challenge, University of Louisville College of Business; 2014 - 3rd place, Postdoctoral and Graduate student poster competition, Organismal Biology Category, Missouri Life Sciences Week, University of Missouri; 2013 - 1st place, Medical student poster competition, Health Sciences Research Day, Institute for Clinical and Translational Science, University of Missouri School of Medicine; 2014 Outstanding Graduate Student Teaching Award; Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine; 2012 - 2nd place, Graduate-Professional Council research competition (oral presentation), University of Missouri   7.    Post-­‐Doctoral  Mentor:                            Zonggao  Shi  (’07-­‐‘09);  Suzy  Westfall  (’07-­‐‘11);  Natalie  Moss  (’09);  Anna  Sluzarz  (’10-­‐‘11)        8.  Research  Asst.  Professor  Mentor:  

    Zonggao  Shi  (’10  –  present)        B.    Medical                1.    Medical  Student  Research                            Jason  Pettus  (’08)       Dan  Miller  (’10)       Kim  Ingersoll  (’10)       Sarah  Bradley  (’10)        C.    Undergraduate                  1.    Life  Sciences  Undergraduate  Research  Opportunity  Program  (LS  UROP)                            Kim  Chaffin  (summer  ’07,  ’08)        2.    EXPRESS  Program  Minority  Undergraduate  Student            Maisia  Reid  (’09-­‐‘10)    D.    High  School     1.     CALEB   Summer   Science   program   for  minority   high   school   students   (lecture   on   “Metastasis”)  (’10)      Teaching  Experience  (University  of  Notre  Dame)  

 A.  Graduate/Post-­‐graduate  

1. MS  Mentor  Brian  Kaltenecker,  MS   in  Global  Health   (’12   -­‐   ‘13) Thesis: “HPV Vaccination in Honduras:

Exploring the implementation, vaccination coverage and cost-analysis of a school based delivery model”. Thesis earned the “Outstanding Pass” distinction.

Patrick Rice, ESTEEM Master’s Program (’13 -14) Thesis: “Nanomembrane-Based Nucleic Acid Sensing Platform for Portable Diagnostics Used for the Early Detection of Human Papillomavirus-Associated Oral Cancer” Marcy Kreimer, Master of Science in Patent Law (’13 -14) Thesis: “A Method and Composition for Detection of Oncogenic HPV” Raymond Kim, MS in Global Health (’14-pres)

2. Ph.D.Mentor     Yuliya  Klymenko  (’11-­‐present)     Elizabeth  Loughran  (’14-­‐present);  NSF  Graduate  Research  Fellowship  2014-­‐2017  3.    Medical  Student     Stephanie  Cripps  (summer  ’14),  Univ  of  Toledo  College  of  Medicine  -­‐  Immunohistochemical     Analysis  of  Ovarian  Tumor  Proliferation  4.    Post-­‐doctoral  Fellow  Mentor     Jing  Yang  (’13  -­‐  ‘15)     Tyvette  Hilliard  (’15-­‐)  5.    Research  Specialist     Jing  Yang  (’15  -­‐  present)  6.    Research  Asst.  Professor  Mentor     Zonggao  Shi  (’10-­‐present)     Jun  Peng  (’11  –‘13)  7.  Courses:    CHEM  90628  Signal  Transduction  (winter  2012)            CHEM  60534  Biochemical  Methods  (winter  2013,  2014,2015)  

         CHEM  60680    Biomedical  Research  Ethics  (fall  2013)      

B.    Undergraduate  1.     Kaitlyn   Conley-­‐   Chemistry/Biochemistry   (’11   -­‐   ‘14)   Identification   of   Wnt   pathway  

components  in  Epithelial  Ovarian  Cancer,  summer  research  fellowship  2013  2.     Emily   Spulak   -­‐   Biological   Sciences   (’11   -­‐   12)  Epithelial-­Mesenchymal   Transition   in   Equine  

Laminitis  3.    Jill  Guinco  -­‐  Science  Business  (’11  -­‐  12)  Epithelial-­Mesenchymal  Transition  in  Equine  Laminitis  4.  Matthew  Metzinger  -­‐  Science  Preprofessional  (’12-­‐‘15)  Obesity  and  Ovarian  Cancer  Metastatic  

Success;   winner   of   “Indiana   Careers   at   Notre   Dame”   award   to   support   summer   research,  summer   2012;   winner   of   College   of   Science   Undergraduate   Research   Fellowship   (COS-­‐SURF)   to   support   summer   research   2013;   3rd   Place   Undergraduate   Poster   Prize,   Harper  Cancer  Research  Institute  Second  Annual  Research  Day,  April  2013;  Baten  Fellow  summer  2013;  2nd  Place  Undergraduate  Poster  Prize,  Harper  Cancer  Research  Institute  Third  Annual  Research  Day,  April  2014;  MD  Anderson  Comprehensive  Cancer  Center  “Cancer  Prevention  and  Research  Institute  of  Texas  (CPRIT)”  summer  fellowship  awardee  2014.  

5.    Kyle  Lewellen  -­‐  Biochemistry  (’13-­‐‘15)  In  vivo  Models  of  Ovarian  Cancer  Metastasis;  winner  of  Indiana  Clinical  Translational   Science   Institute   (iCTSI)   summer   research   fellowship  2013;  MD  Anderson  Comprehensive  Cancer  Center  “Cancer  Prevention  and  Research  Institute  of  Texas  (CPRIT)”  summer  fellowship  awardee  2014  

6.   Ryan   Huhn   -­‐   Science   Preprofessional   (’13-­‐‘15)   Collection   of   Oral   Rinse   Samples   for   HPV  Analysis;   team   member   of   NanDio   business   plan   team   -­‐   winner   of   business   plan  competitions  Cardinal  Challenge  (Louisville,  KY  March  2014)  and  McCloskey  Business  Plan  Competition  (Notre  Dame,  IN,  April  2014)  

7.    Conor  Kirol  (’13)  Genome  Editing  in  Oral  Cancer,  summer  research  fellowship  2013  8.    Marissa  Guo  (’13)  Ovarian  Cancer  Metastatic  Success  9.    Krystal  Quispe  (’13-­‐‘15)  Regulation  of  Ovarian  Cancer  Metastasis  10.   Russell   Williams   (’13-­‐   ‘14)   Indiana   University   South   Bend   undergraduate,   Cadherin  

Expression   in   HPV+   Oral   Cancer;   NSF   REU   Integrated   Cell   &   Molecular   Biology   Program  summer   2014   (Stack   lab)   -­‐  Kallikreins   in   Oral   Cancer,  REU   Research   Presentation   Poster  Prize  winner  August  2014  

11.    Elizabeth  Harper  (summer  ’14,  Earlham  College)  -­  Immunohistochemical  Analysis  of  Murine  Tumors  

12.     Kyle   Carey   (’14-­‐   present)   -­   Immunohistochemical   Analysis   of   Vessel   Density   in   Ovarian  Tumors,  College  of  Science  Summer  Undergraduate  Research  Fellow  2015  

13.    Marielle  Blumenthaler  (’14-­‐‘15)    Effects  of  Aging  on  Peritoneal  Microarchitecture  14.   Eric   Lee   (’14-­‐   present)   -­   Obesity   and   Liver   Fibrosis,   Harper   Cancer   Research   Institute  

Summer  Undergraduate  Research  Fellow  2015  15.  William  Kasberg  (’14-­‐  present)  -­  MT1MMP  in  Ovarian  Cancer  16.   Anne   Grisoli   (’14-­‐   present)   -­   Intra-­peritoneal   Immune   Cells,   College   of   Science   Summer  

Undergraduate  Research  Fellow  2015  17.    Brandi  Bos  (’14-­‐present)  -­  Multicellular  Aggregates  in  Ovarian  Cancer  Metastasis  18.     Ryan   Phan   (’14-­‐present)   -­‐   Ageing   and   Intraperitoneal   Ovarian   Cancer   Metastasis,   Glynn  

Family  Honors  Program  Summer  Research  Fellow  2015  19.    Nalani  Olguin  (’15)  MicroRNA  Targets  in  Oral  Cancer,  University  of  Hawaii  undergraduate,  

NSF  NEU  Integrated  Cell  &  Molecular  Biology  Program  summer  2015  20.    Annemarie  Leonard  (’15-­‐present)  Parity  and  Ovarian  Cancer  Metastasis  21.    Courses:  

  BIOS  46490 Senior Honors Seminar (2012)     CHEM  23202  Biochemistry  of  Cancer  seminar  (winter  semester  2012)     SCPP23100  Seminar  in  Preprofessional  Studies  (03/20/12)     CHEM  23212    Biochemistry  seminar  (10/30/12,  12/13,  10/14)     SC/SCS  33902  Science  Policy  Ethics  (02/25/13,  02/14)     BIOS  46490 Senior Honors Seminar (10/08/13) SCPP 23100 Seminar in Preprofessional Studies (02/17/15)    

  C.    High  School       1.     Brianne   Flanagan   -­‐   Berrien   County   Mathematics   and   Science   Center/Edwardsburg   High  School         (2013)   -­‐  Evaluation   of   Fat   Content   in   Tissues   of  Western   Diet  Mice;   “Finalist”,   Intel  International         Science  &    Engineering  Fair  2013.       2.    Eric  Lee  -­‐  Penn  High  School,  Granger  IN  (2013)  -­‐  Examination  of  Protein  Expression  in             Premalignant  Oral  Lesions       3.    Ashley  Jean-­‐Pierre  -­‐  Penn  High  School,  Granger  IN  (2014)  -­  Quantitation  of  Liver  Adipositiy  in         Three  Mouse  Models  Fed  Control  vs  Western  Diet       4.    Theresa  Rice  -­‐  Marian  High  School,  South  Bend,  IN  (2014-­‐2015)  -­  p16,  PAP,  and  Keratin           Staining  in  Cells  from  Oral  Rinse          Local  Committee  Service  (Northwestern): 1. Integrated Graduate Program, Program Committee, Head, Molecular Biology and Genetics Track, ‘98-’99 2. Integrated Graduate Program, Program Committee Head - Cancer Biology Track, ‘99-‘02 3. Integrated Graduate Program Qualifying Exam Committees - ‘95- present 4. Integrated Graduate Program, Head of “Cancer Biology” track qualifying exam - ‘04 5. Integrated Graduate Program Dissertation Committees: Laura Viise (Gardiner, Pathology) ‘95-’98 Lisa McCawley (Hudson, Molecular Pharmacology) ‘95-’98 Amy Wagers (Kansas, Microbiology/Immunology) ‘95-’99 Jennifer MacGregor (Jordan, Microbiology/Immunology) ‘96 - ‘01 Sharon Sintich (Lee, Urology) ‘96-’99 Larry Goldfinger (Jones, Cell & Molecular Biology) ‘96 - ‘99 Leslie Bannon (Green, Pathology) ‘96 - ‘01 Shawn Ellerbroek (Stack, Cell & Molecular Biology) ‘97-‘01 Mahesh Alur (Wang, Urology) ‘97 - '06 Greg de Hart (Jones, Cell & Molecular Biology) ‘99 -‘03 Yi Wu (Stack, Cell & Molecular Biology) ‘99 - ‘04 Marcie Vana (Leis, Microbiology/Immunology) ‘00 - ‘04 Luisa Hiller (Haldar, Pathology) ‘00 - '05 Debra Dossing (Stern, Molecular Pharmacology) ‘01- '05 Taofei Yin (Green, Pathology) ‘01 - '05

Nick Giafis (Platanias, Hematology/Oncology) ‘04 - '06 Jamie Symowicz (Stack, Cell & Molecular Biology) ‘03 – ‘07 Jennifer Hobbs (Soff, Hematology/Oncology) ‘03 – ‘06 Derek Applewhite (Borisy, Cell&Molecular Biology) ‘04 - Yvonne Wu (Jones, Cell & Molecular Biology) ‘05 - Clarissa Schumacher (Bergan, Urology) ‘05 – ‘07 Krista Toriello (Borisy, Cell & Molecular Biology) ‘05 - Ramona Bhattacharya (MSTP) (Jones, Cell & Molecular Biology) ‘05 -

Jane Maduram (MSTP) (Jones, Cell & Molecular Biology) ‘05 - Natalie Moss (Stack, Cell & Molecular Biology) '05 - Amanda Redig (MSTP) (Platanias, Hematology/Oncology) '06 - 6. Lectures in the Life Sciences Program Committee ‘98/99 7. Institutional Review Board - Panel B ‘96 - ‘99 8. Department of Pathology Basic Science Endowed Professor Search Committee ‘99 9. Search Committee for Dean of the Northwestern University Medical School and Vice President for Medical Affairs, August 1999-February 2000. 10. Search Committee for Chair of Obstetrics and Gynecology, September 2000-2001 11. Radiation Oncology Search Committee Chair, 2001-2002 12. Search Committee for Cancer basic science faculty, 12/03 - 12/04 13. Pathology Department Internal Review Committee, 12/04 - 06/05 Local Committee Service (University of Missouri): 1. Chair, School of Medicine Faculty Appointment, Promotions and Tenure (FAPT) Committee – ‘08 –’09 (member ’07-’10) 2. Chair, School of Medicine Faculty Research Council – ’09-’10 (member ’07-’11) 3. School of Medicine Scientific Peer Review Committee (Vice Chair)– 01/08 - ‘11 4. University of Missouri Research Board grant reviewer – 2007 - present 5. American Association of Medical Colleges Group on Women in Medical Sciences (GWMIS-AAMC), University of Missouri representative, ’09-‘11 6. Department of Pathology & Anatomical Sciences Promotion and Tenure Committee –‘07 – ‘11 7. Graduate Student Thesis/Dissertation Committees: Julie Weaver (Animal Science, Timms) ’07- ‘10 Rong Jiang (Pathology Master’s Program, Stack) ’08 – ‘10 Rebecca Burkhalter (Medical Physiology Pharmacology, Stack) ’08 – ‘12 Lana Bruney (Medical Physiology Pharmacology, Stack) ’09 – present Yuliya Klymenko (Pathology Master’s Program, Stack) ’09 – ‘12 Rong Hu (Interdisciplinary Neuroscience Program, Gu) ’09 – ‘10 Daniel Miller (MD/PhD Pathobiology Area Program, Stack) ’10-‘14 8. School of Medicine Research Administrators Council – 06/07 -05/08 9. School of Medicine Faculty Orientation and Retention Committee – ’08-‘09 Local Committee Service (University of Notre Dame):

1. Department of Chemistry & Biochemistry Safety Committee ’11-present 2. Graduate Student Thesis/Dissertation Committees:

a. Yuliya Klymenko (Biological Sciences, Stack) – ’11 – b. Alissa Schunter (Chemistry/Biochemistry, Hummon) – ’11 – c. Katrina Gellerman (Chemistry/Biochemistry MS, Cowden-Dahl) - ’12 - ‘13 d. Brian Kaltenecker (Global Health MS, Stack) - ’12- ‘13 e. Tiffany Snow (Chemistry/Biochemistry, Castellino) - ’13 - f. Chao Yang (Chemistry/Biochemistry, Littlepage) - ’13 -‘14 g. Patrick Rice (ESTEEM, Stack) -’13-‘14 h. Marcy Krimeir (Master of Science in Patent Law, Stack) - ’13-‘14 i. Victoria Zellmer (Biological Sciences, Zhang) - ’14 - j. Patricia Skallos (Biological Sciences, Zhang) - ’14 -

k. Elizabeth Loughran (Integrated Biomedical Sciences, Stack) -’14 - l. Beth Facchine (Chemistry/Biochemistry, Littlepage) - ’14 - m. Katelyn Ludwig (Chemistry/Biochemistry, Hummon) - ’14 - n. Wendy Alvarez-Barrios (Biological Sciences, Zhang) - ‘14- o. Ricardo Romero Moreno (Chemistry/Biochemistry, Littlepage) - ’14 - p. Charissa Quinlin (Integrated Biomedical Sciences, Bilgicer) - ’14 -

3. Indiana University School of Medicine-South Bend Primary Committee - ’11 - ‘13 4. Department of Chemistry & Biochemistry Vision Committee ’12 - present 5. Chair, Interdisciplinary Faculty Search Committee, Harper Cancer Research Institute - 02/11 -

present 6. Harper Cancer Research Institute Executive Committee - 01/12 - 7. Indiana Clinical Translational Science Institute internal grant reviewer ’12, ’13, ‘14 8. Faculty Mentoring Committee

a. Siyuan Zhang (Biological Sciences) - ’12 - b. Reginald Hill (Biological Sciences) - ’12 - c. Karen Cowden-Dahl (Indiana University School of Medicine South Bend) - ’11 - d. Jeni Prosperi (Indiana University School of Medicine South Bend) - ’13 - e. Laurie Littlepage (Chemistry & Biochemistry) - ’13 -

9. Member, Provost’s Blue Ribbon Committee on faculty experience at Notre Dame - 12/13 - 08/14 10. Member, Steering Committee, Advanced Diagnostics & Therapeutics - ’15 -

Outreach (University of Notre Dame)

1. Speaker, Pink Zone Luncheon , sponsored by College of Science and Women’s Basketball team,

Feb. 14, 2011 2. IUSOM-SB Oncology Advisory Board Meeting, Sept. 7, 2011 3. Saturday Science Exploration Series “Introducing Harper Cancer Research Institute”, Sept. 17, 2011. 4. IUSOM-SB Women’s Health Initiative “Ovarian Cancer”, Sept. 26, 2011. 5. Susan B. Komen for the Cure Luncheon “Harper Cancer Research Institute”, Oct. 6, 2011. 6. Kelly Cares Foundation Post Signing Day Dinner, Feb. 2012 7. Relay 4 Life Opening Ceremony, Notre Dame Stadium, April 2012 8. Notre Dame President’s Circle, November 2012 9. Speaker, Pink Zone Luncheon, sponsored by College of Science and Women’s Basketball team, Feb.

2, 2013 10. Edwardsburg Middle School Career Day “Consider a Career in Cancer”, Feb. 25, 2013 11. RiverBend Cancer Services “In the Pipeline, Around the Bend” presentation to cancer survivors and

their families, April 2013. 12. Building Bridges, “How To Conduct Research” panel discussion with minority pre-professional

students, April 2013. 13. Relay 4 Life Opening Ceremony, Notre Dame Compton Family Ice Arena (interview by Digger

Phelps w/ UND undergraduate Matthew Metzinger), April 2013 14. Memorial Hospital Inservice “The Harper Cancer Research Institute Tissue Biorepository”, April 9-

10, 2013 15. Ovarian Cancer National Alliance Capitol Hill Advocacy Day, July 2013, Washington DC 16. Board Member, River Bend Cancer Services - 01/14 – 17. Gyna Girls (gynecologic cancer support group), “Ovarian Cancer Research at Harper Cancer

Research Institute”, Feb 2014. 18. Edwardsburg Middle School Career Day “Consider a Career in Cancer”, Feb. 2014

19. Dooley Society (Notre Dame medical alumni), “Overview of Harper Cancer Research Institute”, April 2014.

20. Board Member, Northern Indiana Cancer Research Consortium, ’14 - 21. Game Day Saturday Science Lecture “Harper Cancer Research Institute: Changing the Way We

Fight Cancer”, October 2014. 22. Speaker, American Cancer Society Relay for Life Conference, Lakeville, IN, November 2014. 23. Pink Zone Women’s Basketball fundraiser luncheon, Feb. 01, 2015. 24. Speaker, American Cancer Society Lakeshore Division Senior Leadership Team dinner, “Research

Cures Cancer”, Feb. 25, 2015 25. Edwardsburg Middle School Career Day, “Consider a Career in Cancer”, Feb 27, 2015.

Refereed Journal Articles: 1. Gibson, D.M., Stack, S., Krell, K., House, J. (1982) A Comparison of Soybean Agglutinin in Cultivars

Resistant and Susceptible to Phytopthera megaspoerma. Plant Physiol. 70, 560-566. 2. Smith, C., Stack, M.S., Johnson, D.A. (1987) Ozone Effects on Inhibitors of Human Neutrophil

Proteinases. Arch. Biochem. Biophys. 253, 146-155. 3. Stack, M.S., Smith, C., Dean, W.L., and Johnson, D.A. (1987) Bronchial Leukocyte Proteinase

Inhibitor: Hydrodynamic Properties and Interaction with Alpha2-Macroglobulin-Bound Elastase. Arch. Biochem. Biophys. 260, 400-407.

4. Stack, M.S. and Gray, R.D. (1989) Comparison of Vertebrate Collagenase and Gelatinase Using a New Fluorogenic Substrate Peptide. J. Biol. Chem. 264, 4277-4281.

5. Burns, F.R., Stack, M.S., Gray, R.D., Paterson, C.A. (1989) Inhibition of Purified Collagenase from Alkali-Burned Rabbit Corneas. Invest. Opthalmol. Vis. Sci. 30, 1569-1575.

6. Darlak, K., Miller, R.B., Stack, M.S., Spatola, A.R., and Gray, R.D. (l990) Thiol-based Inhibitors of Mammalian Collagenase: Substituted Amide and Peptide Derivatives of the Leucine Analogue, 2-[(R,S)-Mercaptomethyl]-4-methylpentanoic acid. J. Biol. Chem. 265, 5199-5205.

7. Stack, M.S. and Gray, R.D. (1990) The Effect of pH, Temperature and D2O on the Activity of Porcine Synovial Collagenase and Gelatinase. Arch. Biochem. Biophys. 281, 257-263.

8. Stack, M.S., Gonzalez-Gronow, M., Pizzo, S.V. (l990) Regulation of Plasminogen Activation by Components of the Extracellular Matrix. Biochemistry 29, 4966-4970.

9. Stack, M.S., Gonzalez-Gronow, M., Pizzo, S.V. (1991) The Effect of Divalent Cations on the Conformation and Function of Human Plasminogen. Arch. Biochem. Biophys. 284, 58-62.

10. Stack, M.S., Gray, R.D. and Pizzo, S.V. (1991) Modulation of Plasminogen Activation and Type IV Collagenase Activity by a Synthetic Peptide Derived From the Laminin A Chain. Biochemistry 30, 2073-2077.

11. Gonzalez-Gronow, M., Stack, M.S., and Pizzo, S.V. (1991) Plasmin Binding to the Plasminogen Receptor Enhances Catalytic Efficiency and Activates the Receptor for Subsequent Ligand Binding. Arch. Biochem. Biophys. 286, 625-628.

12. Stack, M.S., Emberts, C., and Gray, R.D. (1991) Application of N-Carboxyalkyl Peptides to the Inhibition and Affinity Purification of the Porcine Matrix Metalloproteinases Collagenase, Gelatinase, and Stromelysin. Arch. Biochem. Biophys. 287, 240-249.

13. Stack, M.S., Moser, T., and Pizzo, S.V. (1992) Binding of Human Plasminogen to Basement Membrane (type IV) Collagen. Biochemical Journal 284, 103-108.

14. Stack, M.S., Pizzo, S.V. and Gonzalez-Gronow, M. (1992) Effect of Desialylation on the Biological Properties of Plasminogen. Biochemical Journal 284, 81-86.

15. Young, T.N., Edelberg, J.M., Stack, M.S. and Pizzo, S.V. (1992) Ionic Modulation of the Effects of Heparin on Plasminogen Activation by Tissue Plasminogen Activator. Arch. Biochem. Biophys. 296, 530-538.

16. Stack, M.S., Gray, R.D. and Pizzo, S.V. (1993) Modulation of Murine B16F10 Melanoma Plasminogen Activator Production by a Synthetic Peptide Derived from the Laminin A Chain. Cancer Research 53, 1998-2004.

17. Moser, T.L., Enghild, J.J., Pizzo, S.V. and Stack, M.S. (1993) The Extracellular Matrix Proteins Laminin and Fibronectin Contain Binding Domains for Human Plasminogen and Tissue Plasminogen Activator. J. Biol.Chem. 268, 18917-18923.

18. Stack, M.S. and Pizzo, S.V. (1993) Modulation of Tissue Plasminogen Activator-Catalyzed Plasminogen Activation by Synthetic Peptides Derived from the Amino-Terminal Heparin Binding Domain of Fibronectin. J. Biol. Chem. 268, 18923-18927.

19. Moser, T.L., Young, T.N., Rodriguez, G., Pizzo, S.V., and Stack, M.S. (1994) Secretion of Extracellular Matrix-Degrading Proteinases is Enhanced in Ovarian Epithelial Carcinoma. Int. J. Cancer 56, 552-559.

20. Stack, M.S. and Pizzo, S.V. (1994) The Effect of Substituted Laminin-Derived Peptides on the Conformation and Activation Kinetics of Human Plasminogen. Arch. Biochem. Biophys. 309, 117-122.

21. Stack, M.S. and Johnson, D.A. (1994) Human Mast Cell Tryptase Activates Single Chain Urinary-type Plasminogen Activator (Prourokinase). J. Biol. Chem. 269, 9416-9419.

22. Young, T.N., Rodriguez, G., Moser, T., Bast, R.C., Pizzo, S.V. and Stack, M.S. (1994) Co-ordinate Expression of Urinary-type Plasminogen Activator (u-PA) and its Receptor Accompanies Malignant Transformation of Ovarian Epithelium. Am. J. Obstet. Gynecol. 170, 1285-1296.

23. Young, T.N., Pizzo, S.V. and Stack, M.S. (1995) A Plasma Membrane-Associated Component of Ovarian Adenocarcinoma Cells Enhances the Catalytic Efficiency of Matrix Metalloproteinase-2. J. Biol. Chem. 270, 999-1002.

23. Moser, T.L., Enghild, J.J., Pizzo, S.V. and Stack, M.S. (1995) Specific Binding of Urinary-type Plasminogen Activator (u-PA) to Vitronectin and its Role in Mediating u-PA-Dependent Adhesion of U937 Cells. Biochemical Journal 307, 867-873.

24. Stack, M.S., Rinehart, A. and Pizzo, S.V. (1995) Comparison of Plasminogen Binding and Activation on Extracellular Matrices Derived from Smooth Muscle and Endothelial Cells. European J. Biochem. 226, 937-943.

25. Young, T.N., Rodriguez, G.C., Bast, R.C., Pizzo, S.V.,and Stack, M.S. (1996) Characterization of Gelatinases Linked to Invasion in Ovarian Carcinoma: Purification of Matrix Metalloproteinase 2. Gynecologic Oncology 62, 89-99.

26. Moser, T.L., Pizzo, S.V. Bafetti, L., Fishman, D., and Stack, M.S. (1996) Evidence for Preferential Adhesion of Ovarian Epithelial Carcinoma Cells to Type I Collagen Mediated by the alpha2beta1 Integrin. Int. J. Cancer, 67:695-701.

27. Stack, M.S., Itoh, Y., Young, T.N. and Nagase, H. (1996) Fluorescence Quenching Studies of Matrix Metalloproteinases (MMPs): Evidence for Structural Rearrangement of the proMMP- 2/TIMP-2 Complex upon Mercurial Activation. Arch. Biochem. Biophys. 333:163-169.

28. Gately, S., Twardowski, P., Stack, M.S., Patrick, M. Boggio, L., Cundiff, D.L., Schnaper, H.W., Madison, L., Volpert, O., Bouck, N., Enghild, J., Kwaan, H.C., and Soff, G. (1996) Human Prostate Carcinoma Cells Express Enzymatic Activity that Converts Human Plasminogen to the Angiogenesis Inhibitor Angiostatin. Cancer Research 56:4887-4890.

29. Fishman, D.A., Bafetti, L.M., and Stack, M.S. (1997) Membrane-Type Matrix Metalloproteinase Expression and Matrix Metalloproteinase Activation in Primary Human Ovarian Epithelial Cells. Invasion and Metastasis, 16:150-159.

30. Tolsma, S.S., Stack, M.S. and Bouck, N. (1997) Lumen Formation and Other Angiogenic Activities of Cultured Capillary Endothelial Cells Are Inhibited by Thrombospondin-1. Microvascular Research 54:13-26.

31. Fishman, D.A., Bafetti, L.M., Banionis, S., Kearns, A.S., Chilukuri, K., and Stack, M.S. (1997) Production of Extracellular Matrix Degrading Proteinases by Primary Cultures of Human Epithelial Ovarian Carcinoma Cells. Cancer 80:1457-63.

32. Gately, S. Twardowski, P., Stack, M.S., Cundiff, D.L., Weiss, I., Grella, D., Castellino, F.J., Enghild, J.J., Kwaan, H.C., Lee, F., Kramer, R.A., Volpert, O., Bouck, N., and Soff, G.A. (1997) The Mechanism of Cancer-Mediated Conversion of Plasminogen to the Angiogenesis Inhibitor Angiostatin. Proc. Nat. Acad. Sci., 94: 10868-10872.

33. Fishman, D.A., Chilukuri, K., and Stack, M.S. (1997) Biochemical Characterization of Primary Peritoneal Carcinoma Cell Adhesion, Migration and Proteinase Activity. Gynecologic Oncology, 67:193-199.

34. Xu, F.J., Stack, M.S., Boyer, C., O’Briant, K., Whitaker, R., Mills, G.B., Yu, Y.H., Bast, R.C., Jr. (1997) Heregulin and Agonistic anti-p185 (c-erbB2) Antibodies Inhibit Proliferation but Increase Invasiveness of Breast Cancer Cells That Overexpress p185 c-erbB2: Increased Invasiveness May Contribute to Poor Prognosis. Clin. Can. Res. 3:1629-1634.

35. Bafetti, L.M., Young, T.N., Itoh, Y. and Stack, M.S. (1998) Intact Vitronectin Induces Matrix Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinases-2 Expression and Enhanced Cellular Invasion by Melanoma Cells. J. Biol. Chem.273:143-149.

36. Thomas, V.A., Wheeless, C.J., Stack, M.S., and Johnson, D.A. (1998) Human Mast Cell Tryptase Fibrinogenolysis: Kinetics, Anticoagulation Mechanism and Cell Adhesion Disruption. Biochemistry, 37:2291-2290.

37. Goldfinger, L.E., Stack, M.S., and Jones, J.C.R. (1998) Processing of Laminin-5 and its Physiological Consequences: Role of Plasmin and Tissue-type Plasminogen Activator. J. Cell Biology 141:255-265.

38. Ellerbroek, S.M., Hudson, L.G. and Stack, M.S. (1998) Proteinase Requirements of Epidermal Growth Factor Induced Ovarian Cancer Cell Invasion. Int. J. Cancer 78:331-337.

39. Rao, C.N., Cook, B., Liu, Y., Chilukuri, K., Stack, M.S., Foster, D.C., Kisiel, W., and Woodley, D.T. (1998) HT-1080 Fibrosarcoma Cell Matrix Degradation and Invasion Are Inhibited by the Matrix-Associated Serine Protease Inhibitor TFPI-2/33 kDa MSPI. Int. J. Cancer 76:749-756.

40. Fishman, D.A., Kearns, A.M., Chilikuri, K., Bafetti, L.M., O’Toole, E.A., Georgacopoulos, J., Ravosa, M.J., and Stack, M.S. (1998) Metastatic Dissemination of Human Ovarian Epithelial Carcinoma is Promoted by α2β1 Integrin-Mediated Interaction with Type I Collagen. Invasion and Metastasis 18:15-26.

41. Ellerbroek, S.M., Kearns, A.M., Bafetti, L.M., Fishman, D.A. and Stack, M.S. (1999) Ovarian Carcinoma Regulation of Matrix Metalloproteinase-2 and Membrane Type-1 Matrix Metalloproteinase Through beta1 Integrin. Cancer Research 59: 1635-1641.

42. Moser, T.L., Stack, M.S. , Asplin, I., Enghild, J.J, Hojrup, P., Hubchak, S. Schnaper, H.W. and Pizzo, S.V. (1999) Angiostatin Binds ATP Synthase on the Surface of Human Endothelial Cells.. Proc. Natl. Acad. Sci. USA 96:2811-2816.

43. Stack, M.S., Gately, S., Bafetti, L.M., Enghild, J.J., and Soff, G.A. Angiostatin Inhibits Endothelial and Melanoma Cellular Invasion by Blocking Matrix-Enhanced Plasminogen Activation (1999) Biochem. J. 340: 77-84.

44. Fishman, D.A., Kearns, A., Larsh, S., Enghild, J.J., and Stack, M.S. (1999) Autocrine Regulation of Growth Stimulation in Human Epithelial Ovarian Carcinoma by Serine Proteinase-Catalyzed Release of the Urinary-type Plasminogen Activator Amino Terminal Fragment. Biochem. J. 341:765-769.

45. Liu, Y, Stack,   MS, Lakka, SS, Khan, AJ, Woodley, DT, Rao, JS, and Rao, CN (1999) Matrix Localization of TFPI-2/MSPI Involves Arginine-Mediated Ionic Interactions with Heparin and Dermatan

Sulfate: Heparin Accelerates the Activity of TFPI-2/MSPI Towards Plasmin. Archives Biochem. Biophys. 370:112-118.

46. Ghosh, S., Brown, R., Jones. J.C.R., Ellerbroek, S.M. and Stack,  M.S. (2000) Urinary-Type Plasminogen Activator (uPA) Expression and uPA Receptor Localization Are Regulated by alpha3beta1 Integrin in Oral Keratinocytes. J. Biol. Chem. 275:23869-23876.

47. Goldfinger, L.E., Hopkinson, S.B., Stack,  M.S., and Jones, J.C.R. (2000) Spatial Regulation and Affinity Modulation of Plasmin by High-Affinity Binding to the G Domain of the 3 Subunit of Laminin-5. J. Biol. Chem. 275:34887-93.

48. Rodriguez, G.C., Haisley, C., Hurteau, J. Moser, T.L., Whitaker, R., Bast, R.C., Jr. and Stack,  M.S. (2000) Regulation of Invasion of Epithelial Ovarian Cancer by Transforming Growth Factor Beta. Gynecologic Oncology 80:245-253.

49. Rao, C.N., Reddy, P., Reeder, D.J., Liu, Y., Stack, S., Kisiel, W., and Woodley, D.T. (2000) Prokaryotic Expression, Purification, and Reconstitution of Biological Activities (Antiprotease, Antitumor, and Heparin-Binding) for Tissue Factor Pathway Inhibitor-2. Biochem. Biophys. Res. Commun. 276: 1286-1294.

50. Ellerbroek, S.M., Halbleib, J., Benevidez, M., Wattenbeg, E.V., Stack, M.S. and Hudson, L.G. (2001) Requirement for Phosphatidylinositol 3-Kinase Activity in Epidermal Growth Factor-Stimulated Matrix Metalloproteinase (MMP)-9 Production and Cell Surface Association. Cancer Research 61: 1855-1861.

51. Fishman, D.A., Liu, Y., Ellerbroek, S.M. and Stack,   M.S. (2001) Lysophosphatidic Acid Promotes Matrix Metalloproteinase Processing and MMP-Dependent Invasion in Ovarian Carcinoma Cells. Cancer Research 61, 3194-3199.

52. Ellerbroek, SM, Wu, Y.I., and Stack,   M.S.   (2001)   Type I Collagen Stabilization of Matrix Metalloproteinase-2. Arch. Biochem. Biophys. 390:51-56

53. Ellerbroek, S.M., Wu, Y., Overall, C.M. and Stack,  M.S. (2001) Functional Interplay Between Type I Collagen and Cell Surface Matrix Metalloproteinase Activity. J. Biol. Chem. 276:24833-42.

54. Bannon, L.J., Stack,  M.S., and Green, K.J. (2001) Limitation of Comparative Detection of Proteins via Epitope Tagging. Anal. Biochem.  293:139-­‐42.  

55. Bannon, L.J., Cabrera, B.L., Stack, M. S. and Green, K.J. (2001) Isoform-Specific Differences in the Size of Desmosomal Cadherin/Catenin Complexes. J. Invest. Derm. 117:1302-1306.

56. Mauceri, H.J., Seetharam, S., Beckett, M.A., Lee, J.Y., Gately, S., Stack,  M.S.,  Brown C.K., Swedberg, K., Gupta, V.K., Kufe, D.W., and Weichselbaum, R.R. (2002) Tumor Production of Angiostatin is Enhanced After Exposure to TNF-alpha . Int. J. Cancer 97:410-415.

57.  Ghosh,  S.,  Munshi,  H.G.,  Sen,  R.,  Linz-­‐McGillem,  L.A.,  Goldman,  R.D.,  Lorch,  J.,  Green,  K.J.,  Jones,  J.C.R.  and  Stack,  M.S.   (2002)  Loss  of  Adhesion-­‐Regulated  Proteinase  Expression  in  Oral  Squamous  Cell  Carcinoma.    Cancer  95:2524-­‐2533.  

58. Munshi, H.G., Ghosh, S., Mukhopadhyay, S., Wu, Y.I., Sen, R., Green, K.G., and Stack, M.S. (2002) Proteinase Suppression   by   E-­‐Cadherin-­‐Mediated   Cell-­‐Cell   Attachment   in   Premalignant   Oral  Keratinocytes.    J.  Biol.  Chem.,  277:38159-­‐38167.  

59.    Tam,  E.,  Wu,  Y.I.,  Butler,  G.S.,  Stack,  M.S.  and  Overall,  C.M.    (2002)  Collagen  Binding  Properties  of  the  MT1-­‐MMP  Hemopexin   C   Domain:   The   Ectodomain   of   the   44   kDa   Autocatalytic   Fragment   of  MT1-­‐MMP   Inhibits   Cell   Invasion   by   Disrupting   Native   Type   I   Collagen   Cleavage.     J.   Biol.   Chem.  277:39005-­‐39014.  

60.   Munshi,   H.G.,   Wu,   Y.I.,   Ariztia,   E.A.   and   Stack,   M.S.   (2002)   Calcium   Regulation   of   Matrix  Metalloproteinase-­‐2-­‐Mediated   Migration   in   Oral   Squamous   Cell   Carcinoma.     J.   Biol.   Chem.   277:  41480-­‐41488.  

61.  Lauer-­‐Fields,  J.L.,  Sritharan,  T.,  Stack,  M.S.,  Nagase,  H.,  and  Fields,  G.B.    (2003)  Selective  Hydrolysis  of  Triple-­‐Helical  Substrates  by  Matrix  Metalloproteinase-­‐2  and  -­‐9.    J.  Biol.  Chem.  278:18140-­‐18145.      

62.   Wu,   Y.I.,   Munshi,   H.G.,   Sen,   R.,   Snipas,   S.J.,   Salvesen,   G.S.,   Fridman,   R.,   and   Stack,   M.S.     (2004)  Glycosylation  Broadens  the  Substrate  Profile  of  Membrane  Type  1-­‐Matrix  Metalloproteinase  (MT1-­‐MMP)  J.  Biol.  Chem.  279:8278-­‐8289.  

63.   Tam,   E.M.,   Morrison,   C.J.,   Wu,   Y.I.,   Stack,   M.S.,   and   Overall,   C.M.   (2004)   Membrane   Protease  Proteomics:   Isotope  Coded  Affinity  Tag/Tandem  Mass  Spectrometry  Identification  of  Novel  MT1-­‐MMP  Substrates.    Proc.  Nat.  Acad.  Sci.  101:6917-­‐6921.  

64.  Mukhopadhyay,   S.M.,  Munshi,   H.G.,   Kambhampati,   S.,   Sassano,   A.,   Platanias,   L.C.   and   Stack,  M.S.    (2004)  Calcium  Induced  Matrix  Metalloproteinase-­‐9  Gene  Expression  is  Differentially  Regulated  by  ERK1/2  and  p38  MAPK  in  Oral  Squamous  Cell  Carcinoma.  J.  Biol.  Chem.,  279:33139-­‐33146.  

65.  Lorch,  J.H.,  Park,  J.K,  Klessner,  J.,  Getsios,  S.,  Stack,  M.S.  and  Green,  K.J.    (2004)  Epidermal  Growth  Factor   Receptor   Inhibition   Promotes   Desmosome   Assembly   and   Strengthens   Intercellular  Adhesion  in  Squamous  Carcinoma  Cells.    J.  Biol.  Chem.279:37191-­‐37200.  

66.   Munshi,   H.G.,   Wu   Y.I.,   Mukhopadhyay   S.,   Koblinski,   J.,   Platanias   L.C.,   and   Stack   M.S.     (2004)  Transforming   Growth   Factor   Beta1-­‐Induced   Pericellular   Collagenolysis   is   Controlled   Through  Differential   Regulation   of   Membrane-­‐Type   1   Matrix   Metalloproteinase   Activity   by   Extracellular  Signal-­‐Regulated  Kinase  1-­‐2  and  p38  Mitogen-­‐Activated  Protein  Kinase.   J.  Biol.  Chem.279:39042-­‐39050.  

67.  Graves,  L.E.,  Ariztia,  E.V.,  Navari,  J.R.,  Matzel,  H.J.,  Stack,  M.  S.  and  Fishman,  D.A.  (2004)    Proinvasive  Properties  of  Ovarian  Cancer  Ascites-­‐Derived  Membrane  Vesicles.    Cancer  Research  64:7045-­‐7049.  

68.   Symowicz,   J.,   Adley,   B.P.,   Woo,   M.   M.,   Auersperg,   N.,   Hudson,   L.G.,   and   Stack,   M.S.     (2005)  Cyclooxygenase-­‐2   Functions   as   a   Downstream   Mediator   of   Lysophosphatidic   Acid   to   Promote  Aggressive  Behavior  in  Ovarian  Carcinoma  Cells.    Cancer  Research  65:2234-­‐42.    

69.    Ning,  Y.,  Zeineldin,  R.,  Liu,  Y.,  Stack,  M.S.,  and  Hudson,  L.G.  (2005)    Downregulation  of  Integrin  α2  Surface  Expression  by  Mutant  Epidermal  Growth  Factor  Receptor  (EGFRvIII)  Induces  Aberrant  Cell  Spreading  and  Focal  Adhesion  Formation.    Cancer  Research  65:9280-­‐6.  

70.     Zeineldin   R.,   Rosenberg  M.,   Ortega   D.,   Chavez  M.G.,  Stack,  M.S.,   Kusewitt   D.F.   and  Hudson   L.G.  (2006)     Mesenchymal   Transformation   in   Epithelial   Ovarian   Tumor   Cells   Expressing   Epidermal  Growth  Factor  Receptor  Variant  III.    Molecular  Carcinogenesis  45:851-­‐60.  

 71.     Ghosh,   S.,   Johnson   J.J.,   Sen,   R.,  Mukhopadhyay   S.,   Liu,   Y.,   Zhang,   F.,  Wei,   Y.,   Chapman,  H.A.,   and  Stack,  M.S.    (2006)  Functional  Relevance  of  Urinary-­‐type  Plasminogen  Activator  Receptor  (uPAR)-­‐alpha3beta1  Integrin  Association  in  Proteinase  Regulatory  Pathways.    J.  Biol.  Chem.281:13021-­‐9.  

72. Ravosa, M.J., Kunwar, R., Nicholson, E.K., Klopp, E.B., Pinchoff, J., Stock, S.R., Stack, M.S. & Hamrick, M.W. (2006) Adaptive plasticity in mammalian masticatory joints. Developments in X-Ray Tomography V. 5th Proceedings of SPIE-Int. Soc. Optical Engineering 6318:1-9.

73. Ravosa, M.J., Kunwar, R., Stock, S.R. & Stack, M.S. (2007) Pushing the limit: Masticatory stress and adaptive plasticity in mammalian craniomandibular joints. J. Exp. Biol. 210:628-41. 74.   Barbolina,   M.V.,   Ariztia,   E.V.,   Adley,   B.P.,   Liu,   Y.,   and   Stack,   M.S.     (2007)   Microenvironmental  

Regulation   of   Membrane   Type   1   Matrix   Metalloproteinase   (MT1-­‐MMP)   Activity   in   Ovarian  Carcinoma  Cells  via  Collagen-­‐Induced  Egr-­‐1  Expression.  J.  Biol.  Chem.  282:4924-­‐31.  

75.    Symowicz,  J.E.,  Adley,  B.P.,  Gleason,  K.,  Fishman,  D.A.,  Hudson,  L.G.  and  Stack,  M.S.    (2007)  Integrin  Engagement   Promotes   Proteinase-­‐Dependent   E-­‐Cadherin   Ectodomain   Shedding   in   Ovarian  Carcinoma  Cells.    Cancer  Research  67:  2030-­‐9.  

76.    Do,  T.V.,   Symowicz   J.C.,  Berman  D.M.,  Liotta  L.A.,  Petricoin  E.F.  3rd,  Stack  M.S.   and  Fishman  D.A.  (2007)   Lysophosphatidic   Acid   Down-­‐Regulates   Stress   Fibers   and   Up-­‐regulates   Pro-­‐Matrix  Metalloproteinase-­‐2  Activation  in  Ovarian  Cancer  Cells.    Molecular  Cancer  Research  5:121-­‐131.  

77.    Wolf,  K.,  Wu,  Y.I.,  Liu,  Y.,  Tam,  E.,  Geiger  J.,  Brocker  E.B.,  Overall  C.,  Stack  M.  S.  and  Friedl  P.  (2007)  High  resolution  topography  and  outcome  of  pericellular  proteolysis:  belt-­‐cleavage,  path  generation  and  invasive  tumor  cell  patterning  .    Nature  Cell  Biology  9:893-­‐904.  

78.    Wu,  Y.I.,  Munshi,  H.G.,  Snipas,  S.J.,  Salvesen,  G.S.,  Fridman,  R.,  and  Stack,  M.S.   (2007)  Activation-­‐Coupled   Membrane   Type   1   Matrix   Metalloproteinase   Membrane   Trafficking.     Biochemical   J.  407:171-­‐7.  

79.    Barbolina, M.V., Adley, B.P., and Stack, M.S. (2008) Wilms’ Tumor Gene Protein 1 is Associated with Ovarian Cancer Metastasis and Modulates Cell Invasion. Cancer 112: 1632-41. NIHMSID127561 80.    Norton,  J.T.,  Witschi  M.A.,  Luong  L.,  Kawamura  A.,  Ghosh  S.,  Stack,  M.S.,  Sim  E.,  Avram  M.J.,  Appella  

D.H.,   Huang   S.   (2008)     Synthesis   and   Anticancer   Activities   of   6-­‐amino   Amonafide   Derivatives.    Anticancer  Drugs  19:23-­‐36.    

81. Cowden-Dahl, K., Symowicz, J., Ning, Y., Gutierrez, E., Fishman, D.A., Adley, B.P., Stack, M. S. and Hudson, L.G. (2008) Matrix Metalloproteinase-9 is a Mediator of Epidermal Growth Factor-Dependent E-cadherin Loss in Ovarian Carcinoma Cells. Cancer Research 68:4606-13. NIHMSID#127554

82. Barbolina, M.V., Adley B.P., Kelly D.L., Fought A.J., Scholtens D., Shea L.D., and Stack, M.S. (2008) Motility Related Actinin Alpha-4 Is Associated with Advanced and Metastatic Ovarian Carcinoma. Laboratory Investigation 88:602-614. PMCID: PMC2849305

83. Wang C., Norton J.T., Ghosh S., Kim J.J., Fushimi K., Wu J.Y., Stack M.S. and Huang S. (2008) PTB Differentially Affects Malignancy in a Cell Line Dependent Manner. J. Biol. Chem. 283: 20277-87.

84. Ravosa, M.J., López, E.K., Menegaz, R.A., Stock, S.R., Stack, M.S. & Hamrick, M.W. (2008) Using “Mighty Mouse” to understand masticatory plasticity: Myostatin-deficient mice and musculoskeletal function. Int. Comp. Biol. 48:345-359. (Invited Symposium Volume on Building a Better Organismal Model: The Role of the Mouse)

84. Pettus, J., Johnson, J.J., Shi, Z., Davis, J.W., Koblinski, J.K., Ghosh, S., Liu, Y., Ravosa, M.J., Frazier, S. and Stack, M.S. (2009) Multiple Kallikrein (5, 7, 8, and 10) Expression in Squamous Cell Carcinoma of the Oral Cavity. Histology & Histopathology 24:197-207. PMCID: PMC2835693

85.    Adley,  B.P.,  Gleason  K.,  Yang,  X.  J.,  and  Stack,  M.S.    (2009)  Expression  of  Membrane  Type  1  Matrix  Metalloproteinase   (MMP-­‐14)   in   Epithelial   Ovarian   Cancer:     High   Level   Expression   in   Clear   Cell  Carcinoma.    Gynecologic  Oncology  112:  319-­‐324.  PMCID:  PMC2663392  

86. Woo, M., Salamanca C., Symowicz, J., Stack, M.S., Leung P., Gilks B., and Auersperg N. (2008) SV40 Early Genes Promote Neoplastic Progression of Serous Borderline Ovarian Tumors. Gynecologic Oncology,111: 125-131.

87. Moss, N.M., Liu, Y., Johnson, J.J., Debiase P., Jones J., Hudson, L.G., Munshi H.G., and Stack, M.S. (2009) Epidermal Growth Factor Receptor-Mediated Membrane Type 1 Matrix Metalloproteinase Endocytosis Regulates the Transition Between Invasive and Expansive Growth in Three-Dimensional Collagen. Molecular Cancer Research 7:809-820. PMCID: PMC2843416.

88. Moss, N.M., Wu Y.I., Liu Y, Munshi H.G. and Stack M.S. (2009) Modulation of the Membrane Type 1 Matrix Metalloproteinase Cytoplasmic Tail Enhances Invasion and Proliferation in Three-Dimensional Collagen Matrices. J. Biol. Chem. 284: 19791-9. PMCID: PMC2740404

89. Ghosh, S., Koblinski, J., Johnson, J., Liu, Y., Frazier, S., Ericcson, A., Shi, Z., Ravosa, M.J., Crawford, S., and Stack, M.S. (2010) Urinary-Type Plasminogen Activator Receptor (uPA/R)/α3β1 Integrin Signaling and Oral Tumor Progression. Mol. Can. Res. 8: 145-158. PMCID: PMC2825738

90. Barbolina M.V., Adley B.P., Kelly D.L., Shepard J., Fought A.J., Scholtens D., Penzes P., Shea L.D. and Stack, M.S. (2009) Downregulation of Connective Tissue Growth Factor by Three-Dimensional Matrix Enhances Ovarian Carcinoma Cell Invasion. Int. J. Cancer 125:816-25. PMC2849282

91. Moss N.M., Barbolina M.V., Liu Y., Sun L., Munshi H.G., and Stack, M.S. (2009) Ovarian Carcinoma Cell Detachment and Multi-cellular Aggregate Formation are Regulated by MT1-MMP: A Potential Role in Intra-Peritoneal Metastatic Dissemination. Cancer Research 69: 7121-9. PMCID: PMC2737080

92. Barbolina M. V., Kim M., Liu Y., Shepard J. Belmadani A., Miller R.J., Shea L.D. and Stack M.S. (2010) Microenvironmental Regulation of Chemokine (C-X-C-motif) Receptor 4 in Ovarian Carcinoma. Molecular Cancer Research 8:653-64. PMC2883461

93. Ravosa, M.J., Ning, J., Costley, D.B., Daniel, A.N., Stock, S.R. & Stack, M.S. (2010) Masticatory biomechanics and masseter fiber-type plasticity. J. Musculoskeletal Neuronal Interactions 10:46-55. (Special Issue on Muscle-Bone Interactions)

94. Jašarević, E., Ning, J., Daniel, A.N., Menegaz, R.A., Johnson, J.J., Stack, M.S. & Ravosa, M.J. (2010) Masticatory loading, function and plasticity: A microanatomical analysis of mammalian circumorbital soft-tissue structures. Anat. Record 293A:642-50. (Special Issue on Experimental Approaches to Primate Morphology)

95. Ravosa M.J., Ning J., Liu Y., and Stack, M.S. (2010) Bisphosphonate Effects on the Behavior of Oral Epithelial Cells and Oral Fibroblasts. Arch. Oral Biol. 56: 491-498. PMID21146154

96. Jiang R, Shi Z., Johnson J.J., Liu Y. and Stack, M.S. (2011) Kallikrein-5 Promotes Cleavage of Desmoglein-1 and Loss of Cell-Cell Cohesion in Oral Squamous Cell Carcinoma. J Biol. Chem, 286:9127-35. PMC3059049

97. Burkhalter R., Symowicz J., Hudson L.G., Gottardi C.J., and Stack M.S. (2011) Integrin Regulation of β-catenin Signaling in Ovarian Carcinoma. J. Biol. Chem. 286: 23467-75. PMC3123110

98. Shi Z., Johnson J., Liu Y., Stack M.S. (2011) Urinary-type plasminogen activator receptor (uPAR) modulates oral cancer cell behavior with alteration in p130cas. Mol. Cell. Biochem. 357: 151-161.

99. Rodriguez G.C., Turbov J.M., Berchuck A., Stack, M.S., Hurteau J.A., Thaete L.G., Barry C.P. (2012) Non-Steroidal Anti-inflammatory Drugs and Progestins Synergistically Enhance Cell Death in Ovarian Epithelial Cells. Am J Obstet Gynecol, 206; e1-9.

100. Liu Y., Burkhalter R., Symowicz J., Chaffin K., Ellerbroek S. and Stack M.S. (2012) Lysophosphatidic Acid Disrupts Junctional Integrity and Epithelial Cohesion in Ovarian Cancer Cells. J Oncol., epub 501492. PMC3346998

101. Dong Y., He Y., deBoer L, Stack M.S., Lumley J.W., Clements J.A., and Hooper J.D. (2012) Disruption of the Cell Surface Glycoprotein CUB Domain Containing Protein 1 (CDCP1) Contributes to Epidermal Growth Factor Receptor-Mediated Cell Migration. J. Biol. Chem., 287(13):9792-803.

102. Shi Z., Johnson J.J., Stack, M.S. (2012) Fluorescence in situ Hybridization for microRNA Detection in Archived Oral Cancer Tissues. J. Oncol: epub 903581. PMC3359729

103. Barbolina M.V., Liu, Y., Gurler, H., Kim M., Kajdacsy-Balla A.A., Rooper L., Shepard J., Weiss M., Shea L.D., Penzes P., Ravosa M.J., and Stack M.S. (2013) Matrix Rigidity Activates Wnt Signaling Through Downregulation of Dickkopf-1. J. Biol. Chem 288:141-151. PMC3537008

104. Wang, L., Pawlak, E., Johnson, P.L., Belknap J.K., Stack, S., Cousin, H., and Black S.M. Impact of Laminitis on the Canonical Wnt Signaling Pathway in Basal Epithelial Cells of Equine Digital Laminae PLoS One. 2013;8(2):e56025. doi: 10.1371/journal.pone.0056025. Epub 2013 Feb 6. PMID: 23405249

105. Xu, H., Liu, Y., Stack, M.S., Ptasinska S. (2013) Treatment of Oral Cancer Cells with Nitrogen Atmospheric Pressure Plasma Jets. Appl. Phys. Letters, 102:233703-5.

106. Lengyel, E., Burdette, J., Kenny, H., Matei, D., Pilrose, J., Haluska, P., Nephew, K.P., Hales, D. B., and Stack, M.S. (2013) Epithelial Ovarian Cancer Experimental Models. Oncogene, Aug 12 doi: 1038/onc.2013.321 . PMC3990646

107. Shi, Z., Johnson, J.J., and Stack, M.S. (2013) Detecting microRNA in Human Cancer Tissues with Fluorescence in situ Hybridization. Methods Mol. Biol. 1039: 19-27.

108. Johnson, J.J., Shi, Z., Liu, Y., and Stack, M. S. (2014) Inhibitors of Nf-kappaB Reverse Cellular Invasion and Target Gene Upregulation in an Experimental Model of Aggressive Oral Squamous Cell Carcinoma. Oral Oncology 50: 468-477. NIHMSID: 572471. PMC4001858.

109. Bruney, L., Conley, K.C., Liu Y., Stack, M.S. (2014) MT1-MMP-Dependent Shedding of Muc16 (CA125) on Ovarian Cancer Cells Modulates Mesothelial Adhesion. Biological Chemistry 395:1221-31.

110. Senapati, S., Slouka, Z., Shah, S.S., Behura, S.K., Shi, Z., Stack, M.S., Severson, D.W. and Chang, H.-C. (2014) An ion-exchange nanomembrane sensor for detection of nucleic acids using a surface charge inversion phenomenon. Biosens Bioelectron. 60C: 92-100 doi: 10.1016/j.bios.2014.04.008.

111. Metzinger, M., Miramontes, B., Zhou P., Liu, Y., Peng, J., Chapman, S., Sun, L., Sasser, T.A., Duffield, G.E., Stack, M.S., Leevy, W.M. (2014) Correlation of X-Ray Computed Tomography with Quantitative Nuclear Magnetic Resonance Methods for Pre-Clinical Measurement of Adipose and Lean Tissues in Living Mice. Sensors 14:18526-18542.

112. Xu, H., Liu, Y., Stack, M.S., Ptasinska, S. (2014) 3D Mapping of Plasma Effective Areas via Detection of Cancer Cell Damage Induced by Atmospheric Pressure Plasma Jets. Journal of Physics: Conference Series 565: 012011, 1-6.

113. Miller, D.M., Davis, J.W., Taylor, K.H., Johnson, J., Shi, Z., Williams, R., Atasoy, U., Lewis, J.S., and Stack, M.S. (2015) Identification of an Oncogenic microRNA Panel in Human Oropharyngeal Squamous Cell Carcinoma Validated by Bioinformatics Analysis of The Cancer Genome Atlas (TCGA). Amer. J. Pathol. 185: 679-692.

114. Burkhalter, R.J., Westfall, S.D., Liu, Y., and Stack, M.S. Lysophosphatidic Acid Initiates Epithelial to Mesenchymal Transition and Induces beta-Catenin-Mediated Transcription in Epithelial Ovarian Carcinoma (in revision)

115. Shi, Z., Johnson, J.J., Jiang, R., Liu, Y., and Stack, M.S. Decreased miR-146a is associated with aggressive human oral squamous cell carcinoma (in revision)

116. Lewellen K., Metzinger M., Liu, Y. and Stack M.S. Quantitation of Intra-Peritoneal Ovarian Cancer Metastasis (in revision).

117. Liu, Y., Yang, J., Metzinger, M., Lewellen, K., Conley, K.C., Leevy, M., Flanagan, B., Jean-Pierre, A., Sluzarz, A., Klymenko, Y., Johnson, Y., Shi, Z., Bruney, L., Liang, Z., Loughran, E. and Stack, M.S. Does Obesity Impact Ovarian Cancer Metastatic Success? (in review)

118. Slouka, Z., Senapati, S., Shah, S., Lawler, R., Shi, Z., Stack, M.S., and Chang, H.-C. Integrated, DC voltage-driven nucleic acid diagnostic platform for real sample analysis: detection of oral cancer (in review)

119. Mitra A., Davis D., Tomar, S., Roy, L., Gurler, H., Xie J., Lantvit, D.D., Cardenas, H., Fang, F., Liu, Y., Loughran, E., Yang, J., Stack, M.S., Emerson, R.E., Cowden Dahl, K., Barbolina, M., Nephew, K.P., Matei D., Burdette, J.E. (2015) In vivo Tumor Growth of High-Grade Serous Ovarian Cancer Cell Lines. Gyn. Oncology (in press)

119. Johnson, J.J., Shi, Z., Stack, M.S. Proteinase-Activated Receptor-2 (PAR2) Activation Modulates microRNA Expression in Oral Cancer (in prep)

120. Liu, Y., Loughran, E., Stack, M.S. Microanatomy of Peritoneal Structures in Murine Models of Obesity (in prep)

121. Klymenko, Y., Liu, Y., Yang, J., Stack, M.S. Lysophosphatidic Acid Modulates Ovarian Cancer Multi-Cellular Aggregate Dynamics (in prep)

Book Chapters and Invited Reviews: 1. Stack, M.S., Madison, E.L., and Pizzo, S.V. (1995) Tissue-Type Plasminogen Activator, in Molecular

Basis of Thrombosis and Hemostasis, Roberts, H.R. and High, K.A., eds., Marcel Dekker Inc., pp. 479-494

2. Stack, M.S., Ellerbroek, S.M. and Fishman, D.A. (1998) The Role of Proteolytic Enzymes in the Pathology of Ovarian Carcinoma (Review), Int. J. Oncology 12: 569-576.

3. Ellerbroek, S.M. and Stack,   M.S. Membrane-Associated Matrix Metalloproteinases in Metastasis (Review) (1999) Bioessays 21: 940-949.

4. Ghosh, S., Wu, Y., Ellerbroek, S.M., and Stack,   M.S. (2000) Tumor Cell Mediated Proteolysis: Regulatory Mechanisms and Functional Consequences. Fibrinolysis and Proteolysis 14:87-97.

5. Ghosh, S. and Stack,  M.S. (2000) Structural and Functional Modifications of Laminins by Proteolytic Cleavage. Microscopy Research and Technique 51:238-246.

6. Ghosh,  S.,  Wu,  Y.,  and  Stack,  M.S. (2001) Ovarian Cancer-Associated Proteinases, in. Cancer Treatment and Research: Ovarian Cancer, Stack, M.S. and Fishman, D.A., Editors Kluwer Academic Publishers, pp.331-351.

7. Mills, G.B., Eder, A, Fang, X., Hasegawa, Y., Mao, M., Lu, Y., Tanyi, J., Tabassam, F.H., Wiener, J., Lapushin, R., Yu, S., Parrott, J.A., Compton, T., Tribley, W., Fishman, D., Stack, M.S., Gaudette, D., Jaffe, R., Furui, T., Aoki, J., Erickson, J.R. (2001) Critical Role of Lysophospholipids in the Pathophysiology, Diagnosis, and Management of Ovarian Cancer, in Cancer Treatment and Research: Ovarian Cancer, Stack, M.S. and Fishman, D.A., Editors Kluwer Academic Publishers, pp 259-284.

8. Stack, M.S. (2001) Matrix Metalloproteinases, in Cancer: An Encyclopedic Reference, Springer Verlag, in press.

9. Ellerbroek, S.M., Wu, Y., and Stack,  M.S. (2002) Regulatory Mechanisms for Proteinase Activity, in Proteinase and Peptidase Inhibition: Recent Potential Targets for Drug Development, Smith, H.J. and Simons, C. eds., Taylor and Francis, London, pp. 21-34

10. Moser, T.L., Stack,  M.S., Wahl, M.L., and Pizzo, S.V. (2002) The Mechanism of Action of Angiostatin, Thrombosis and Haemostasis 87:394-401.

11. H.G. Munshi and M. Sharon Stack (2002) Analysis of Matrix Degradation in Methods in Cell Biology 69: 195-205, Methods in Cell-Matrix Adhesion, Academic Press, San Diego.

12. DeClerck,   Y.A.,   Mercurio,   A.M.,   Stack,   M.S.,   Chapman,   H.A.,   Zutter,   M.M.,   Muschel,   R.J.,   Raz,   A.,  Matrisian,   L.M.,   Sloane,   B.F.,   Noel,   A.,   Hendrix,   M.J.,   Coussens,   L.,   and   Padarathsingh,   M.   (2004)  Proteases,  Extracellular  Matrix,  and  Cancer:  a  workshop  of  the  path  B  study  section.    Am.  J.  Pathol.  164:1131-­‐1139.  

13.  Munshi,  H.G.  and  Stack,  M.S.    (2006)  Reciprocal  Interactions  Between  Adhesion  Receptor  Signaling  and  MMP  Regulation,  for  Cancer  Metastasis  Reviews    25:  45-­‐56.

14. Shi, Z., and Stack, M.S. (2007) Urinary-Type Plasminogen Activator (uPA) and its Receptor (uPAR) in Oral Squamous Cell Carcinoma of the Oral Cavity. Biochemical Journal 407: 153-9. 15. Ravosa, M.J., López, E.K., Menegaz, R.A., Stock, S.R., Stack, M.S. & Hamrick, M.W. (2008) Adaptive

plasticity in the mammalian masticatory complex: You are what, and how, you eat. C.J. Vinyard, M.J. Ravosa & C.E. Wall (Eds.): Primate Craniofacial Biology and Function. New York: Springer Academic Publishers, pp. 293-328.

16. Barbolina, M. and Stack, M.S. (2008) Membrane Type-1 Matrix Metalloproteinase: Substrate Diversity in Pericellular Proteolysis. W. Parks, Ed. Seminars in Cell and Develop. Biol., 19:24-33. PMCID: PMC2685078 17. Hudson, L.G., Zeineldin, R., and Stack, M.S. (2008) Phenotypic Plasticity of Neoplastic Ovarian

Epithelium: Unique Cadherin Profiles in Tumor Progression. Clin. Exp. Metastasis, 25: 643-55. PMCID: PMC2836537

18. Barbolina, M.V., Moss, N.M., Westfall, S.D., Liu Y., Burkhalter, R.J., Marga, F., Forgacs, G., Hudson, L.G. and Stack, M.S. (2009) Microenvironmental Regulation of Ovarian Cancer Metastasis, in Ovarian Cancer; Stack M.S. and Fishman, D.A., Editors. Springer, 319-334.

19. Hudson, L.G., Zeineldin, R., Silberberg, M. and Stack, M.S. (2009) Activated EGF Receptor in Ovarian Cancer; in Ovarian Cancer; Stack M.S. and Fishman, D.A., Editors. Springer, 203-228.

20. Hudson, L.G., Moss, N.M., and Stack, M. S. (2009) Epidermal Growth Factor Receptor Regulation of Matrix Metalloproteinases in Epithelial Ovarian Carcinoma. Future Oncology 5:323-38. PMCID: PMC2709955

21. Shi Z and Stack, M.S. (2010) Molecules of Cell Adhesion and Extracellular Matrix Proteolysis in Oral Squamous Cell Carcinoma. Histology Histopathology 25:917-932.

22. Zeineldin, R., Muller C.Y., Stack M.S. and Hudson L.G. (2010) Targeting the EGF Receptor for Ovarian Cancer Therapy. J Oncology 2010:414676. PMCID: PMC2801454

23. Hudson, L.G. and Stack, M.S. Integrins and Cancer. Chapter 24 in The Tumor Microenvironment, Springer, Boston, pp 509-529.

24. Munshi, H.G. and Stack, M.S. (2010) Understanding Epithelial-Mesenchymal Transition May Reveal Novel Therapeutic Targets for Oral Squamous Cell Carcinoma, Current Cancer Therapy Reviews 6.

25. Barbolina M.V., Burkhalter R.J. and Stack M.S. (2011) Diverse Mechanisms for Activation of Wnt Signaling in the Ovarian Tumor Microenvironment. Biochemical Journal 437, 1-12. PMC3133882

26. Miller D.L., Puricelli M.D., and Stack M.S. (2012) Virology and Molecular Pathogenesis of HPV-Associated Oropharyngeal Squamous Cell Carcinoma. Biochemical Journal 443:339-353.

27. Jiang, R., Shi, Z., Johnson, J. and Stack, M.S. (2012) Pathophysiology of Kallikrein Proteases in Head and Neck Cancer, in Kallikrein Related Peptidases, V. Magdolen and C. Sommerhof, eds., de Gruyter Press, 45-60.

28. Miller, D.M. and Stack, M.S. (2015) Human Papillomavirus-Associated Oropharyngeal Cancer, Springer Press (edited volume in press)

29. Miller, D.M. and Stack, M.S. (2015) MicroRNA Profiles of HPV-Associated Oropharyngeal Squamous Cell Carcinoma (OPSCC), in Human Papillomavirus-Associated Oropharyngeal Cancer; Miller, D.M. and Stack, M.S., eds., Springer Press (in press)

30. Crawford, H.C., and Stack, M.S. (2015) Matrix degradation, Signaling and Compliance in From Biological Mechanisms to Therapeutic Opportunities, J Gaffney and I Sagi, Editors. Wiley. (in press)

31. Shi, Z., and Stack, M.S. (2015) An Update on Immunohistochemistry in Translational Cancer Research. Cancer Translational Science (in press).

Oral Presentations at National and International Symposia: 1. Stack, M.S., Gonzalez-Gronow, M., and Pizzo, S.V. (l990) Protein Components of the Extracellular

Matrix Stimulate Plasminogen Activation. International Congress on Fibrinolysis; Indianapolis, IN. Fibrinolysis 4 (suppl.3), 81.

2. Stack, M.S., Moser, T.L, and Pizzo, S.V. (1991) Extracellular Matrix Regulation of Thrombolysis. FASEB, Atlanta, GA. FASEB Journal, 5, A515.

3. Stack, M.S., Moser, T.L., and Pizzo, S.V. (1991) Regulation of Tissue Plasminogen Activator-Catalyzed Plasminogen Activation by Extracellular Matrix Proteins. XIIIth International Congress on Thrombosis and Haemostasis, Amsterdam, The Netherlands. Thrombosis and Haemostasis 65, 722.

4. Stack, M.S., Moser, T.L. and Pizzo, S.V. (1992) Intact and Degraded Matrix Proteins Regulate Plasminogen Activation. Eleventh International Congress on Fibrinolysis, Copenhagen, Denmark. Fibrinolysis 6 (suppl. 2), 257.

5. Stack, M.S. and Pizzo, S.V. (1994) The Effect of Substituted Laminin A Chain-Derived Peptides on the Activation Kinetics and Zymogen Conformation of Plasminogen. XIIth International Congress on Fibrinolysis, Leuven, Belgium. Fibrinolysis 8, suppl. 1, 1.

6. Stack, M.S., Young, T.N., Moser, T.L. and Pizzo, S.V. (1995) Extracellular Matrix Regulation of Metastasis-Associated Proteinases. Amer. Assoc. for Cancer Research, Toronto, Ontaria, Canada. Proceedings of the AACR 36, 709-710.

7. Stack, M.S., Moser, T.L., Bafetti, L.M., Pizzo, S.V., and Fishman, D.A. (1996) Role of Adhesion and Proteolysis in Epithelial Ovarian Carcinoma Dissemination. XIIIth International Congress on Fibrinolysis, Barcelona, Spain. Fibrinolysis 10, suppl. 3, 26.

8. Bafetti, LM, Young, TN, Itoh, Y, and Stack,   MS (1996) Intact Vitronectin Induces Coordinate Expression of Matrix Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinases-2 by Melanoma Cells. Inhibitors of Metalloproteinases Conference, Banff, Alberta, Canada.

9. Bafetti, LM and Stack,   MS (1996) Intact Vitronectin Induces Coordinate Expression of Matrix Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinases-2 in Melanoma Cells. Midwest Connective Tissue Workshop, Rush University Medical School, Chicago, IL.

10.     Stack, M.S., Goldfinger, L.E., and Jones, J.C.R. (1997) Post-translational Plasmin Proteolysis of Laminin-5 Regulates Hemidesmosome Assembly and Cell Motility. VIth International Workshop on

the Molecular and Cellular Biology of Plasminogen Activation, San Diego, CA. Fibrinolysis & Proteolysis 11, suppl.3, 11.

11. Moser, T.L., Pizzo, S.V., Enghild, J.J., Hubchak, S., and Stack, M.S. (1997) Isolation of an Angiostatin Receptor from the Membranes of Human Umbilical Vein Endothelial Cells. VIth International Workshop on the Molecular and Cellular Biology of Plasminogen Activation, San Diego, CA. Fibrinolysis & Proteolysis 11, suppl. 3, 39.

12. Gately, S., Twardowski, P., Stack, M.S., Cundiff, D.L., Grella, D, Castellino, F.J., Enghild, J., Kwaan, H.C., Lee, F., Kramer, R.A. and Soff, G.A. (1997) The Mechanism of Cancer-Mediated Conversion of Plasminogen to the Angiogenesis Inhibitor Angiostatin. VIth International Workshop on the Molecular and Cellular Biology of Plasminogen Activation, San Diego, CA. Fibrinolysis & Proteolysis 11, suppl. 3, 39.

13. Bafetti, LM, Ellerbroek, SM and Stack,   MS (1997)A Functional Link Between Adhesion and Proteolysis. Gordon Research Conference on Matrix Metalloproteinases, Plymouth, NH.

14. Stack,   MS (1998) Angiostatin in Matrix Remodeling. 5th International Meeting of the European Vascular Biology Association, Leuven, Belgium.

15.   Ellerbroek,   SM,  Wu,   Y,   and   Stack,  MS   (1999)   Cellular   Regulation   of  Matrix  Metalloproteinase-­‐2  Processing.  (MS  Stack, Session Leader, Cellular Regulation Session) Gordon Research Conference on Matrix Metalloproteinases, New London, NH.

16. Ghosh, S., Brown, R. and Stack,  M.S. (1999) A Functional Link between 1 Integrin Aggregation, uPA Expression and uPAR Localization in Premalignant Oral Epithelial Cells. International Protease Society, Mackinac Island, MI.

17. Ghosh, S. and Stack,  M.S. (2000) Integrin Regulation of PA and MMP Expression (MS Stack, Session Leader, Metalloproteinases and Plasminogen Activators in Physiology and Pathology) Thrombolysis Gordon Research Conference, Ventura, CA.

18. Ellerbroek, S.M., Ghosh, S., Fishman, D.A. and Stack,  M.S. (2000) uPA Regulation in Ovarian Cancer. 15th International Congress on Fibrinolysis and Proteolysis, Hamamatsu, Japan.

19. Ghosh, S., Wu, Y., Ellerbroek, S.M., and Stack,  M.S. (2000) State   of   the   Art   Lecture “Tumor Cell Mediated Proteolysis: Regulatory Mechanisms and Functional Consequences”. 15th International Congress on Fibrinolysis and Proteolysis, Hamamatsu, Japan

20. Ellerbroek, S.M., Ghosh, S., Fishman, D.A., and Stack,  M.S. (2000) uPA Regulation in Ovarian Cancer. Satellite Symposium, 15th International Congress on Fibrinolysis and Proteolysis, Hamamatsu, Japan

21. Stack,   M.S. (2000) Matrix Metalloproteinase Regulation in Ovarian Metastasis. Society for Gynecologic Investigation, Chicago, IL

22. Ghosh, S., Munshi, H.G., Sen, R., Green, K.G. and Stack, M.S. (2001) Proteinase Suppression  by  E-­‐Cadherin-­‐Mediated   Cell-­‐Cell   Attachment   in   Premalignant  Oral   Keratinocytes. VIIIth International Workshop on Molecular and Cellular Biology of Plasminogen Activation, Jackson Hole, WY.

23. Wu, Y.I., Ariztia, E., Munshi, H.G., Snipas, S., Salvesen, G.S. and Stack, M.S. (2001) Pondering Proteolytic Potential. 2nd General Meeting of the International Proteolysis Society, Freising, Germany.

24. Stack, M.S. (2002) The Basic Biology of Angiostatin. at Cancer, Angiogenesis and Thrombosis Symposium, Asheville, NC.

25. Stack, M. S., S. Ghosh, H.G. Munshi, S. Mukhopadhyay, R. Sen and Y. Liu. (2002) Cellular Control of Proteolytic Potential via Differential Engagement of Adhesion Receptors. American Association for Cancer Research Special Symposium on Proteases, Extracellular Matrix, and Cancer. Hilton Head, SC.

26. Wu Y.I., Munshi H.G. and Stack, M.S. (2003)   Post-­‐Translational   Processing   Broadens   the  Substrate   Profile   of   MT1-­‐MMP.   Gordon   Research   Conference   on  Matrix   Metalloproteinases   (M.S.  Stack,  Session  Leader,  Collagenolysis  Session),  Big  Sky  Valley,  MT.    

27. Ghosh, S., Munshi, H.G., and Stack, M.S. (2004) Adhesion Regulated Proteinase Activity. Gordon Research Conference on Plasminogen and Extracellular Proteolysis (M. S. Stack, Session Chair), Ventura, CA.

28. Stack, M.S. (2005) Pondering the Proteolytic Potential of MT1-MMP. Pacific Coast Protease Workshop, Half Moon Bay, CA, April 2005.

29. Stack, M.S. (2005) American Society for Biochemistry and Molecular Biology Delegation to China (Beijing, Guangzhou, Shanghai). Proteinase Regulation in the Tumor Microenvironment; June 2005.

30. Stack, M.S. (2005) Mechanisms of Metastasis. Bea Schriesheim Ovarian Cancer Research Symposium, Chicago, IL, September 2005.

31. Ghosh, S., Johnson, J. and Stack, M.S. (2006) Functional Relevance of uPAR/Integrin Interactions in Proteinase Regulatory Pathways. Gordon Research Conference on Plasminogen and Extracellular Proteolysis, Ventura, CA.

32. Symowicz, J., Barbolina, M., Liu, Y., and Stack, M.S. (2006) Proteinase Regulation in the Ovarian Tumor Microenvironment. 18th International Congress on Fibrinolysis and Proteolysis: Proteolysis in the Postgenomic Era, San Diego CA.

33. Stack, M.S. (2008) Adhesion-Regulated Proteolysis in Ovarian Carcinoma. Gordon Research Conference on Plasminogen Activation and Extracellular Proteolysis, Ventura, CA.

34. Stack, M.S. (2008) Proteinase Regulation in the Ovarian Tumor Microenvironment. Gordon Research Conference on Proteinases and Inhibitors, New London, NH.

35. Johnson J.J., Shi Z., Frazier S., Jiang R., and Stack M.S. (2009) Functional Alteration of Oral Squamous Cell Carcinoma Aggressive Behavior Through uPAR-Associated Changes in Gene Expression. Second World Congress of the International Academy of Oral Oncology, Toronto, Ontario, July 2009 (oral presenter and session co-chair).

36. Johnson J.J., Shi Z., Frazier S., Jiang R., and Stack M.S. (2010) uPAR/Integrin Association and Altered microRNA Regulation in Oral Cancer. Gordon Research Conference on Plasminogen Activation and Extracellular Proteolysis, Ventura, CA, Feb. 2010 (oral presenter and session chair).

37. Moss, N.M., Liu Y., Wu Y.I. and Stack, M.S. (2010) Regulation of Ovarian Cancer Metastasis by Protease Cytoplasmic Tail Phosphorylation. Gordon Research Conference on Proteolytic Enzymes and Their Inhibitors, Il Ciocco, Italy, May 2010 (oral presenter and session chair)

38. Stack, M.S. (2011) Pondering (a few years of) Proteolytic Poetntial. Gordan-Keenan Research Symposium on Matrix Metalloproteinases, Smithfield, RI, August 2011 (keynote speaker)

39. Burkhalter, R.J., Barbolina, M.V., Symowicz, J., Liu, Y., and Stack, M.S. Mechanisms of Wnt Regulation in the Ovarian Tumor Microenvironment. Gordon Conference on Matrix Metalloproteinases, Smithfield, RI, August 2011 (oral presenter, elected Vice Chair for next Gordon Conference)

40. Jiang R, Shi Z, Johnson JJ, Liu Y, Stack MS. Kallikreins, Cleavage, and Cohesion in Oral Cancer. 7th General Meeting of the International Proteolysis Society, Oct. 16-20, 2011, San Diego, CA.

41. Stack, M.S., Burkhalter RJ and Barbolina JV. Cell/Matrix Adhesion and Wnt/β-Catenin Signaling in Ovarian Cancer. 13 Internal Union of Biochemistry and Molecular Biology Cell Signaling Networks Meeting, Oct. 22-27, 2011, Merida, Yucatan, Mexico.

42. Stack, M.S. Aberrant Proteinase Regulation in Epithelial Cancer. Plasminogen Activation and Extracellular Proteolysis Gordon Conference, Ventura, CA, Feb 12-17, 2012. (oral presenter, session chair)

43. Stack, M.S. Epithelial Cell Regulation of Adhesion and Proteolysis. Havemeyer Equine Laminitis Workshop II, Key Largo, FL, April 29-May 2, 2012 (oral presentation).

44. Johnson, J.J., Jiang, R., Shi Z. and Stack, M.S. Kallikreins, Cleavage and Cohesion in Oral Squamous Cell Carcinoma. 1st Symposium on Head and Neck Cancer Stem Cells, Ann Arbor, MI, May 10-11, 2012. 45. Stack, M.S., Burkhalter, R., Barbolina, M.V. Role of Intra-peritoneal Mechanobiology in Mutation- Independent Activation of Wnt Signaling in Ovarian Carcinoma. Workshop on Physical Approaches to Studying the Cytoskeleton and Cell Motility, Chicago, IL, March 2013. 46. Stack, M.S., and Genua, M., Session Chairs for Protease Systems and Receptors in Cancer. XIVth International Workshop on the Molecular and Cellular Biology of Plasminogen Activation, June 2013.

47. Stack, M.S., Liu, Y., Bruney, L., Klymenko, Y., Yang, J. Protease Pathways in Cancer Progression: Intra-peritoneal Mechanobiology and Ovarian Cancer Metastatic Success. 8th General Meeting of the International Proteolysis Society, Capetown, South Africa, October 2013. 48. Stack, M.S. Partnerships in Biobanking: Biobanking Opportunities for Patients in the Community Hospital Setting. 5th International Leaders in Biobanking Congress 2013, Indianapolis, IN, Oct 2013. 49. Stack, M.S. Serine Protease Regulation in Invasive Oral Cancer. Plasminogen Activation and Extracellular Proteolysis Gordon Research Conference, Ventura, CA, Feb. 2014. 50. Stack, M.S. You May Ask Yourself, How Did I Get Here? Plasminogen Activation and Extracellular Proteolysis Gordon Research Seminar, Ventura, CA, Feb 2014. Invited Seminars: May 1990; East Tennessee State University, Johnson City, TN, Department of Biology, “Interaction of

Plasminogen with Basement Membrane Proteins”. May 1990; East Tennessee State University College of Medicine, Johnson City, TN, Department of

Biochemistry, “Novel Regulatory Mechanisms in Fibrinolysis”. February 1991; University of Louisville, Louisville, KY, Department of Biochemistry, “Novel Regulatory

Mechanisms in Fibrinolysis”. February 1992; Wright State Univeristy, Dayton, OH, Department of Biochemistry, “Novel Regulatory

Mechanisms in Fibrinolysis”. March 1992, University of Chicago, Chicago, IL, Department of Pathology, “Interaction of Plasminogen and

Plasminogen Activators with the Basement Membrane”. April 1993, Northwestern University, Chicago, IL, Department of Oral Biology, “Regulation of Plasminogen

Activation by Components of the Extracellular Matrix”. August 1993, University of Kentucky, Lexington, KY, Department of Biochemistry, “Extracellular Matrix

Regulation of Metastasis-Associated Proteinases”. October 1993, Vanderbilt University, Nashville, TN, Department of Pathology, “Extracellular Matrix

Regulation of Metastasis-Associated Proteinases”. December 1993, Northwestern University, Chicago, IL, Department of Obstetrics and Gynecology,

“Extracellular Matrix Regulation of Melanoma and Ovarian Carcinoma-Associated Proteinases”. May 1994, East Tennessee State University College of Medicine, Johnson City, TN, Department of

Biochemistry, “Extracellular Matrix Regulation of Metastasis-Associated Proteinases”. May 1994, National Institutes of Health Institute of Dental Research, Bethesda, MD, “Extracellular Matrix

Regulation of Metastasis-Associated Proteinases”. March 1995 Northwestern University, Chicago, IL, Adhesion, Motility and Angiogenesis Group, “Surface

Regulation of Metastasis- Associated Proteinases”. April 1995, Keynote Speaker, 11th Annual Student Research Forum, East Tennessee State University,

Johnson City, TN “Adhesion and Proteolysis in Epithelial Ovarian Carcinoma”. April 1995, East Tennessee State University College of Medicine, Department of Biochemistry, Johnson

City, TN, “Surface Regulation of Tumor Cell-associated Proteinase Activity”. April 1995, American Association for Cancer Research, Toronto, Ontario, “Extracellular Matrix Regulation

of Metastasis-Associated Proteinases”. May 1995, Duke University Medical Center, Durham, NC, Department of Cell Biology Seminar Series on

the Molecular Basis of Cell Migration, “Proteolysis in Invasion”. October 1995, Upjohn Co., Kalamazoo, MI, “Surface Regulation of Metastasis-Associated Proteinases” February 1996, University of Kansas Medical School, Kansas City, KS, Department of Biochemistry,

“Surface Regulation of Metastasis-Associated Proteinases” February 1996, Abbott Laboratories Distinguished Lecture Series, Abbott Park, IL, “Surface Regulation of

Metastasis-Associated Proteinases”

March 1996, University of Illinois Dental School, Chicago, IL, Department of Oral Biology, “Surface Regulation of Metastasis-Associated Proteinases”

November 1996, University of Louisville, Louisville, KY, Department of Biochemistry, “Surface Regulation of Metastasis-Associated Proteinases”

December 1996, Northwestern University, Chicago, IL, Tumor Cell Biology Lecture Series, “Surface Regulation of Metastasis-Associated Proteinases”

January 1997, Monsanto Corp., St. Louis, MO, “Surface Regulation of Metastasis-Associated Proteinases” August 1997, Matrix Metalloproteinase Gordon Conference, Plymouth, NH, “A Functional Link Between

Adhesion and Proteolysis” December 1997, Abbott Laboratories, Abbott Park, IL, “Angiostatin and Proteolysis” March 1998, Harvard University, Cambridge, MA, “Angiostatin and Proteolysis” March 1998, SUNY, Stony Brook, NY, “Matrix Regulation of Metastasis-Associated Proteinases” April 1998, Northwestern University, Chicago, IL, Reproductive Genetics Series, “Regulation of Ovarian

Carcinoma Metastasis” April 1998, Ontario Cancer Institute, Toronto, Ontario, “Matrix Regulation of Metastasis-Associated

Proteinases” May 1998, 5th Annual Meeting of the European Vascular Biology Association, Leuven, Belgium,

“Angiostatin in Matrix Remodeling” May 1998, University of East Anglia, Norfolk, England, “Matrix Regulation of Metastasis-Associated

Proteinases” December 1998, Northwestern University Cancer Center, Chicago, IL “Tumor Cell-Mediated Proteolysis:

Regulatory Mechanisms and Functional Consequences”. February 1999, Northwestern University Pathology Department, Chicago, IL “Regulation of Ovarian

Carcinoma Metastasis” August 1999, Matrix Metalloproteinase Gordon Conference, New London, NH, (Session Chair) Cellular Regulation Session, “Cellular Regulation of Matrix Metalloproteinase-2 Processing” November 1999, Monsanto, St. Louis, MO, “Integrin Regulation of Metastasis-Associated Proteinases December 1999, Arkansas Cancer Research Forum, Little Rock, AK, “Tumor Cell Mediated Proteolysis:

Regulatory Mechanisms and Functional Consequences” January 2000, Gordon Research Conference on Thrombolysis, Ventura, CA, “Integrin Regulation of PA and

MMP Expression” (Session Chair) April 2000, Notre Dame University, Notre Dame, IN, “Matrix Regulation of Metastasis-Associated

Proteinases” April 2000, University of North Carolina, Chapel Hill, NC, “Tumor Cell-Mediated Proteolysis: Regulatory

Mechanisms and Functional Consequences” April 2000, Duke University, Durham, NC, “Tumor Cell-Mediated Proteolysis: Regulatory Mechanisms and

Functional Consequences” February 2002, Wake Forest University, Winston-Salem, NC, “Pondering Proteolytic Potential” March 2002, Wayne State University Medical Center, Detroit, MI, “Pondering Proteolytic Potential” April 2002, University of Minnesota Medical School, Minneapolis, MN, “Pondering Proteolytic Potential” June 2002, Yale University Medical School, New Haven, CT, “Pondering Proteolytic Potential” September 2002, M.D. Anderson Comprehensive Cancer Center, University of Texas, Houston, TX,

“Pondering Proteolytic Potential” March 2003, Florida State University, Tallahassee, FL, “Pondering Proteolytic Potential” August 2003, Gordon Research Conference on Matrix Metalloproteinases, Big Sky Valley, MT, “Post-

Translational Processing by Glycosylation Broadens the Substrate Profile of MT1-MMP” (Session Chair)

November 2003, University of Illinois, Department of Pharmacology, Chicago, IL, “Adhesion Regulated Proteinase Activity”

December 2003, Fox Chase Comprehensive Cancer Center, Philadelphia, PA, “Proteinase Regulation in the Ovarian Tumor Microenvironment”

February 2004, Gordon Research Conference on Plasminogen and Extracellular Proteolysis, Ventura, CA, “Adhesion Regulated Proteinase Activity” (Session Chair)

June 2004, Duke University, Department of Pathology, Durham, NC, “Pondering Proteolytic Potential” (in Symposium “D-Dimer and Beyond” in honor of S.V. Pizzo)

December 2004, University of Illinois, Chicago, IL, “Proteinase Regulation in Oral Cancer” January 2005, Evanston/Northwestern Healthcare, Evanston, IL, “Proteinase Regulation in the Ovarian

Tumor Microenvironment” January 2005, University of North Carolina, Chapel Hill, NC “Proteinase Regulation in Oral Squamous Cell

Carcinoma” March 2005, University College London Kennedy Institute of Rheumatology, London, UK, “Proteinase

Regulation in the Tumor Microenvironment” May 2005, Rush University Medical Center, Chicago, IL, “Proteinase Regulation in the Tumor

Microenvironment” May 2005, Medical University of SC, Charleston, SC, “Proteinase Regulation in the Tumor

Microenvironment” September 2005, University of Missouri, Columbia, MO, "Proteinase Regulation in the Tumor

Microenvironment December 2005, Medical College of Georgia, Augusta, GA "Proteinase Regulation in the Tumor

Microenvironment" December 2005, Wake Forest University, Winston-Salem, NC, "Proteinase Regulation in the Tumor

Microenvironment" January 2006, Evanston Northwestern Healthcare, Evanston, IL "Proteinase Regulation in the Ovarian

Tumor Microenvironment" February 2006, University of New Mexico, Albuquerque, NM "Proteinase Regulation in the Ovarian Tumor

Microenvironment" April 2006, Loyola University, Chicago, IL "Proteinase Regulation in the Tumor Microenvironment" May 2006, University of Illinois, Champagne-Urbana, IL "Proteinase Regulation in the Tumor

Microenvironment" April 2007, University of Maryland, Baltimore, MD “Proteinase Regulation in the Ovarian Tumor

Microenvironment” May 2007, University of Missouri, School of Veterinary Medicine, “Proteinase Regulation in the Ovarian

Tumor Microenvironment” May 2007, University of Missouri, School of Medicine, Department of Dermatology Research In Progress

Seminars, “Proteinase Regulation in Oral Squamous Cell Carcinoma” January 2008, University of Illinois, Chicago, Oral Cancer Center, “Adhesion-Regulated Proteolysis in Oral

Squamous Cell Carcinoma” February 2008, Barts and The London School of Medicine and Dentistry, Centre for Cancer and

Inflammation, “Proteinase Regulation in the Ovarian Tumor Microenvironment” April 2008, Appalachain Student Research Forum (Keynote Speaker), Johnson City, TN, “Proteinase

Regulation in the Ovarian Tumor Microenvironment” April 2008, East Tennessee State University, Department of Biochemistry, Johnson City, TN, “Adhesion

Regulated Proteolysis in Oral Squamous Cell Carcinoma” November 2008, MD Anderson Cancer Center, University of Texas, Houston, TX, Department of Cancer

Biology, “Proteinase Regulation in the Ovarian Tumor Microenvironment” February 2009, Meharry Medical College, Nashville, TN, Departments of Cancer Biology and

Neurobiology/Neurotoxicology, “Proteinase Regulation in the Ovarian Tumor Microenvironment”

February 2009, University of Missouri, Columbia, MO, Cardiovascular Day, “Proteinase Regulation in the Ovarian Tumor Microenvironment”

April 2010, University of Missouri Post-Doctoral Association discussion group, Columbia, MO “When and How to Say NO”

May 2010, University of Notre Dame, Notre Dame, IN “Regulation of Adhesion and Proteolysis in the Tumor Microenvironment”

January 2011, University of Illinois, Chicago, IL, Department of Biopharmaceutical Sciences, “Regulation of Adhesion and Proteolysis in the Tumor Microenvironment”

January 2011, Northwestern University, Chicago, IL, Epithelial Group Seminar, “Regulation of Adhesion and Proteolysis in the Tumor Microenvironment”

April 2011, Dyax Corp., Cambridge, MA, “Proteinase Regulation in the Tumor Microenvironment” August 2011, University of Louisville, Department of Biochemistry and Molecular Biology Research

Retreat, Louisville, KY “Pondering (a few years) of Proteolytic Potential” October 2011, Indiana University Simon Cancer Center, Indianapolis, IN “Unique Complexities of the

Ovarian Tumor Microenvironment” October 2011, Eli Lilly and Company, Indianapolis, IN “Introducing Harper Cancer Research Institute” March 2012, University of Illinois, Chicago, IL “Kallikreins, Cleavage and Cohesion in Oral Cancer” June 2012, University of Notre Dame, Biochemistry Retreat, “Modeling Epithelial Ovarian Cancer

Metastasis” Apri1 2013, Indiana University School of Medicine, HPV Working Group “HPV-Associated Oropharyngeal

Cancer” May 2013, Memorial Hospital of South Bend Surgery Inservice “The Harper Cancer Research Institute

Tissue Biorepository” October 2013, Notre Dame Institute for Advanced Study “Partnerships in Biobanking” November 2013, Indiana University Bloomington, “Regulation of Ovarian Cancer Metastasis” January 2013, Harper Cancer Research Institute, “Regulation of Ovarian Cancer Metastasis” April 2014, Dooley Society, University of Notre Dame, “Introducing Harper Cancer Research Institute” May 2014, Washington State University, Pullman, WA, “Regulation of Ovarian Cancer Metastasis” May 2014, National Institute of Dental and Craniofacial Research, “Serine Proteinase Regulation in Invasive

Oral Squamous Cell Carcinoma” June 2014, Indiana-Illinois End Epithelial Ovarian Cancer Coalition (IIEEOCC) Workshop, South Bend, IN,

“Does Obesity Impact Ovarian Cancer Metastatic Success?” November 2014, Purdue Center for Cancer Research, “A Tale of Two Tumors: Research in Ovarian and

Oral Cancers”