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CURRICULUM VITAE

Joel Bernard Mason, B.S., M.D.

updated: December 2015

CURRENT TITLES Professor of Medicine, Tufts University School of Medicine Professor of Nutrition, Tufts University School of Nutritional Science and Policy Senior Scientist, U.S.D.A. Human Nutrition Research Center on Aging at Tufts University Director, Vitamins and Carcinogenesis Laboratory, USDA Human Nutrition Research Center on Aging at Tufts University Staff, Division of Clinical Nutrition, Tufts University School of Medicine Staff, Division of Gastroenterology, Tufts University School of Medicine Representative for nutrition and cancer, Research Executive Committee, Tufts Cancer Center OFFICE ADDRESS Human Nutrition Research Center at Tufts University Vitamins and Carcinogenesis Laboratory 711 Washington Street Boston, MA 02111 OFFICE PHONE NUMBER (617) 556-3194 E-MAIL ADDRESS joel.mason@tufts.edu OFFICE FAX (617) 556-3234 EDUCATION

Undergraduate: 1977 B.S., Magna Cum Laude University of Illinois, Urbana, IL

Medical School: 1981 M.D. University of Chicago Pritzker School of

Medicine, Chicago, IL POSTDOCTORAL TRAINING Internship and Residency:

1981-1984 Internal Medicine University of Iowa Hospitals and Clinics, Iowa City, IA

Fellowship: 1984-1987 Gastroenterology, Nutrition University of Chicago Hospitals and

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Clinics, Chicago, IL LICENSURE AND CERTIFICATION

Licenses: 1987-present Board of Registration in Medicine MA, #57484

Certifications: 1982 National Board of Medical Examiners, I-III ID #242294 1984 American Board of Internal Medicine

1987 American Board of Nutrition

1987 American Board of Gastroenterology 2001 American Board of Physician Nutrition Specialists

ACADEMIC APPOINTMENTS March 1987-June 1987, Research Associate, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University

1987-1988, Scientist III, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University

1987-1988, Instructor Tufts University School of Medicine 1988-1996, Scientist II, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University

1996-2010, Scientist I, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University

1988-1997, Assistant Professor, Tufts University School of Medicine

1994-2007, Assistant Professor, Tufts University School of Nutritional Science and Policy

1996-2003, Chief, Division of Clinical Nutrition, Department of Internal Medicine, Tufts University School of Medicine

1997-2010, Associate Professor, Tufts University School of Medicine

2000-2010, Director, Postdoctoral Fellowship, Program in Human Nutrition and Metabolism

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1998-2002, Director, Vitamins and Carcinogenesis Program, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University

2002-present, Director, Vitamins and Carcinogenesis, Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University 2010-present, Senior Scientist, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University 2010-present, Professor, Tufts University School of Nutritional Science and Policy

2010-present, Professor, Tufts University School of Medicine HOSPITAL APPOINTMENTS

1987-present, Staff Physician, Divisions of Clinical Nutrition and Gastroenterology, Tufts Medical Center

1987-2003, Director, Adult Nutrition Support Service, Tufts Medical Center

1996-2003, Chief, Division of Clinical Nutrition, Tufts Medical Center

2005-present, Associate Director, Tufts Cancer Center 2005-present, Program co-Director, Nutrition and Cancer Program, Tufts Cancer Center

AWARDS AND HONORS 1976, Phi Beta Kappa, University of Illinois-Urbana 1977, Bronze Tablet, University of Illinois-Urbana (top 3% of graduating class)

1981, Kraftco award for research in clinical nutrition, University of Chicago School of Medicine 1989, 1992 Outstanding Teaching Contributions to Gastroenterology Training for Tufts and Boston University Fellows at the Boston VA Medical Center

1990, Future Leader in Nutrition, International Life Science Institute Award (ILSI)

1991, SmithKline/Beecham American Gastroenterological Award for Clinical Research

1999, Co-chair, Fourth Nestle′ International Clinical Nutrition Conference, Nutrition and Cancer, Kuala Lampur, Malaysia

2000, Oliver Smith Award, Tufts Medical Center

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2004-2007, Most highly cited paper in the Journal of Nutrition (Choi SW, Mason JB. J Nutr. 2000;130:129-32)

2008, Most highly cited paper in Cancer Epidemiology, Biomarkers, and Prevention (Mason JB et al. Cancer Epidemiol Biomarkers Prevent 2007;16:1325-9)

2005, ’06, ’07, ’08, ’09, ‘10,’11, ‘12 Top Doctors in the US, (top 1% of all physicians), Castle Connolly Limited 2005, ’06, ’07, ’08, ’09, ’10,’11, ‘12 Top Cancer Doctors in the US, Castle Connolly Limited

2008, ’09, ’10, ’11, ’12, ’13, ‘14 Top Gastroenterologists in Greater Boston, Boston Magazine

2011, ‘12 U.S. News & World Report, top 1% of gastroenterologists in U.S.

2009, Invited expert on folate and cancer risk, European Food Safety Authority, Meeting on “Folic Acid: an update on scientific development,” Uppsala, Sweden 2009, Invited consultant on folate consumption and cancer, U.S. Dietary Guidelines Committee 2010, Mary Swartz Rose Senior Investigator Award, American Society for Nutrition 2010, Fellow, American Gastroenterological Association 2014, E.V. McCullom Award, American Society for Nutrition 2015, Top U.S. Doctors for Cancer, Newsweek magazine

HOSPITAL, HNRCA, MEDICAL SCHOOL, & UNIVERSITY COMMITTEE ASSIGNMENTS: 1996, Chairperson, NEMCH Clinical Nutrition Working Group 1997-2002, Chairperson, NEMCH Nutrition Committee (member 1987-present) 1995-present, Member, School of Medicine Nutrition Education Committee 1998-2011, Member, School of Nutritional Science and Policy Committee on Promotions and Appointments

2003, Member, HNRCA Tissue Bank Committee 2003-present, Member, HNRCA Animal User’s Committee 2004, Member, HNRCA Front Lobby Utilization Committee

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2005-2013, Member, Executive Committee, Tufts Cancer Center 2010, Member, HNRCA Joint Advisory Committee 2012, Member, Tufts University Impact on Society Committee 2013-present, HNRCA Committee on Corporate and Foundation Relations 2014, Chair, HNRCA Pilot Grant Review Committee 2014-present, Member, Executive Steering Committee for Research, Tufts Cancer Center

TRAINING OR GRADUATE STUDENTS/POST DOCTORAL (this list includes only those trainees for whom Mason was the primary mentor) Past:

Postdoctoral Research Fellow: Marilia Cravo, MD. 1989-1991. Present position: Staff gastroenterologist and Assoc. Director of Research, Portuguese Institute of Oncology, Lisbon, PORTUGAL.

Postdoctoral Research Fellow: Young-in Kim, MD. 1993-1995. Present position: Professor, Faculty of Medicine, University of Toronto, Toronto, CANADA.

Postdoctoral Research Fellow: Aminah Jatoi, MD. 1996-1997. Present position: Professor of Medicine, Mayo Clinic and School of Medicine, Rochester, MN.

Visiting Scientist, Jean Mayer USDA HNRCA at Tufts University: Hyun Wook Baik, Ph.D., MD. 1996-1997. Present position: Director, Digestive Disease Center, Boondang-Jaesaeng Hospital (affiliate of Seoul National University), Seongnam City, SOUTH KOREA.

MPH Candidate, Tufts University School of Medicine: Kristina Antonsson, BS. 1997-1998. Present position: medical student, International University of Beer-sheva, ISRAEL.

PhD Student, Tufts University School of Nutritional Science and Policy: Farah Esfandiari, M.S. 1995-1999. Present position: Research Assistant Professor, Univ. of California-Davis.

Visiting Scientist, Jean Mayer USDA HNRCA at Tufts University: Sang-Woon Choi, MD. 1994-1999. Present position: Adjunct Scientist I(=Associate Professor), Vitamins & Carcinogenesis Laboratory, HNRCA.

Doctoral Candidate, Tufts University School of Nutritional Science and Policy: Lonelle Ball, M.S. 1999-2000. Present position: Research Associate, Univ. of California, San Francisco, Dept of Surgery.

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Postdoctoral Fellow, Rachel Zand, PhD (Univ. of Toronto). 2000-2002. Present position: Director, Office of Research Ethics, University of Toronto. Postdoctoral Fellow, Jimmy Crott, PhD. (Univ. of Adelaide, AUST) 2001-2004. Present position: Scientist I (=Associate Professor), Vitamins & Carcinogenesis Laboratory, HNRCA. Postdoctoral Fellow, Helen Gabriel D.D.S. (Harvard Univ.), 2001-2003. Present position: mother of twin infants. Medical Student, Aaron Dickstein (Tufts University), summer 2006. Present position: Gastroenterology Fellow, Tufts Medical Center. Post-doctoral fellow, Zhenhua Liu, Ph.D. (Auburn Univ.), 2004-2007. Present position: Assistant Professor, University of Massachusetts-Amherst. Postdoctoral Fellow, Aurelie Chanson, Ph.D. (Auvergne University School of Medicine, FRANCE), 2006-2009. Present position: Senior Scientific Review Officer, V.A.B.-Nutrition Postdoctoral Fellow, Susan Kim, M.D. (Temple University), 2009-2011. Present position: oncologist in private practice Doctoral Student, Eric Ciappio, M.S. (University of Massachusetts, Amherst), 2008-2011. Present position: Scientific Leader for Nutritionals, DSM Nutritional Products Postdoctoral Fellow, Keith Leung, M.D. (University of Michigan), 2011-2013. Present Position: oncologist in private practice. Present: Doctoral student, Anna Pfalzer, B.A.(Grinnell College, IA), 2012-present

TEACHING RESPONSIBILITIES

1988-present, Nutrition and Medicine, Tufts University School of Medicine 1992-present, Lecturer, “Topics in Surgical Nutrition” (Department of Surgery Seminar Series for 3rd Year medical students, Tufts University School of Medicine)

1995-present, Lecturer, “Clinical Applications of B-vitamin Metabolism” and “Nutrition Support and Acute Illness,” Clinical Nutrition course, Frances Stern M.S.R.D. Students, Friedman School of Nutritional Science and Policy

1994-2000, Pathophysiology in Gastrointestinal Disease, Tufts University School of Medicine

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1994-present, Nutritional Biochemistry, Tufts University School of Nutritional Science and Policy

1995-present, Clinical Nutrition in Health and Disease, Tufts University School of Nutritional Science and Policy 1996-1999, Lecturer on ‘Malabsorption’ and ‘Malnutrition’ for Massachussetts College of Pharmacy’s Degree Program for Physician Assistants 1998-present, Geriatric Dentistry, Tufts University School of Dentistry 1998-present, Science of Clinical Nutrition Seminar Series, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University 2008-present, Nutrition, Tufts University School of Medicine (Tufts University MBS Program)

PROFESSIONAL SOCIETIES

• Member, American Society of Nutrition • Fellow, American Gastroenterological Association • Member, American Association for Cancer Research

OFFICE AND COMMITTEE ASSIGNMENTS IN PROFESSIONAL SOCIETIES

1993, ‘94, ‘96, ‘97 American Society of Parenteral Abstract Committee and Enteral Nutrition for Annual Meeting

1995, 2001 American Society for Clinical Nutrition Annual Meeting Steering Committee

1998-2001 American Society for Clinical Nutrition Professional

Nutrition Education Committee

2001-2003 American Society for Clinical Nutrition Award Committee, Physician Nutrition Specialist

2001-3 National Institutes of Health member, NCI Scientific Review Group, Subcommittee G

2002 National Institutes of Health member, NCI special

emphasis panel: ‘Molecular Targets of Nutrients in Prostate

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Cancer Prevention’

2003-2008 National Institutes of Health member, NCI Scientific Review Group, Subcommittee J

2004-08 Am Society for Nutrition member, Nominating

Committee

2006 National Institute of Environmental member, Special Em- Sciences phasis Panel:

‘Environmental influ- ences on epigenetic regulation’

2007-present Am Gastroenterological Association member, Nominating Committee, Section on Nutrition & Obesity

2008-2012 Am Society for Nutrition member, Committee on Continuing Medical Education

(Chairperson 2010- 2012)

2009, 2010 National Cancer Institute ad hoc member,

CDP Scientific Review Group

2011, ‘12 National Cancer Institute Chairperson, NIH Special Emphasis Panel. The Role of Microbial Metabolites in Cancer Prevention and Etiology, PAR-10-208

2013 National Cancer Institute Special Emphasis Panel, L30 loan repayment program 2014 American Institute for Cancer Annual Meeting Research Steering Committee

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2014,’15 American Society for Nutrition Co-chair, Advances and Controversies in Clinical Nutrition 2014-‘16 American Soc. Nutrition member-at-large, Medical Nutrition Council 2015 National Institutes of Health member, NIH Expert Panel on ‘Identifying Research Needs for Assessing Safe Use of High Intakes of Folic Acid’ 2015-‘17 American Soc. Nutrition Director-at-large, ASN Board of Directors

MAJOR RESEARCH INTERESTS My long standing research interest has been basic and applied issues pertaining to the intestinal metabolism of the B vitamin, folate. Over the past two decades, this interest has largely been focused on the question of how alterations in folate status modulate the process of carcinogenesis in the colorectum. My research program encompasses cell culture studies, animal models of carcinogenesis, as well as studies in human subjects. Much of my work has pursued the identification of the molecular mechanism(s) by which this effect is mediated. I have also emphasized the conduct of translational studies to determine the applicability of these mechanistic issues in humans. These human studies have examined both the effects of dietary folate deprivation and folic acid supplementation on biochemical and molecular features of the colon. Consequentially, I have been drawn deeply into the field of biochemical and molecular markers of colon cancer, as well as into issues pertaining to the conduct of large, multi-center trials. More recently this work has extended into examinations of the issue in other organs such as the lung, breast, and oral cavity, and I have also extended our work to include other biochemically related nutrients such as vitamins B-2, B-6, and B-12. Over the past two years my laboratory has also devoted increasing energies towards defining the mechanistic basis of how obesity enhances colorectal carcinogenesis. We are performing animal studies as well as translational studies in human subjects. RESEARCH SUPPORT *all monies reflect annual direct funds unless specified otherwise

Current: Combination regimen to prevent obesity-promoted colon cancer: animal studies ‘Tufts Collaborates’ grants program $50,000 9/01/15-08/31/16

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Principle Investigator Nutrition and Cancer Prevention U.S. Department of Agriculture, 1950-5100-074-01S $271,000 10/01/2004-09/30/2014 (renewed annually, peer-reviewed every 5 years) Principle Investigator Folate and PSMA Interact to Regulate DNA Methylation and Prostate Carcinogenesis NIH, 1 RO1 CA138444-01A2 $219,962 04/01/2010-01/31/2015 Consultant (PI: O’Keefe, DS)

Obesity, inflammation, and colon carcinogenesis Prevent Cancer Foundation $80,000 02/14/2013-02/14/2015 Principle Investigator Translational study of TNF-α-mediated Wnt-signaling as a molecular mechanism for obesity-associated colorectal carcinogenesis HNRCA Pilot Program $50,000 04/01/11-09/30/14 (NCE) Principle Investigator Dietary and genetic inhibitions of TNF-a suppresses obesity-associated intestinal

tumorigenesis via diminishing Wnt signaling (PI: Liu, Zhenhua) U.S.D.A. Agriculture and Food Research Initiative (AFRI) program $160,000 02/01/14-01/31/18 Co-Investigator Evaluation of Glycemic Index to Assess Diet-Associated Chronic Disease Risk NIH, R01 DK073321-04 (PI: Lichtenstein AH) 09/01/07-08/31/14 (NCE) Study Physician

Past Ten Years: Defining the promoting effect of folate on colorectal cancer in a novel animal model NIH, R21CA150118-01A1 $275,000 02/01/2011-01/31/2013 Principle Investigator

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Interaction between one-carbon nutrient status and polymorphisms in uracil repair genes in determining DNA stability U.S. Department of Agriculture/CSREES Award $100,000.00 12/01/2008-11/30/2010

Principal Investigator Doctoral Program in Human Nutrition and Metabolism NIDDK, 5 T32 DK 007651 $245,000.00 07/01/98-06/30/2010 Principal Investigator *This grant is used to support stipends and training related expenses for research fellows The MTHFR C677T SNP exerts bipolar effects on colorectal cancer risk through the Wnt pathway NCI 1R21ES019102 $205,125 09/30/2009-06/30/2011 (NCE through 6/30/12) Effects of aging and folate on colonic carcinogenesis NIA, 5 RO1 AG025834 $803,600 03/01/2007-02/28/2012 Co-Investigator (PI: Choi, S-W) Folate 1-carbon nutrients, gene variants, and colon cancer NCI, U54 CA100971 $134,591.37 (for Mason's Project) 09/01/2003-08/31/2009 (NCE) Project Director for Animal Studies One-carbon vitamin depletion enhances throughput through the Wnt-signaling pathway: a mechanism for colorectal tumorigenesis Prevent Cancer Foundation $80,000.00 01/15/2008-01/14/2010 Co-Investigator (PI: Liu, Z)

Modulation of Colorectal Carcinogenesis by Dietary Folate Tufts Medical Center Cancer Center, Pilot Study Grant $40,000.00 06/01/2008-05/31/2009 Co-Principal Investigator (Co-PI: Hung, K, Tufts Medical Center)

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Folate concentrations in the human colon U.S. Department of Agriculture/Agriculture Research Service $62,994.00 10/01/2006-03/31/2009 Principal Investigator Effect of folate status on genetic/epigenetic stability and tumorigenicity U.S. Department of Agriculture National Research Initiative Grant $365,040.00 08/2006-08/2009 (NCE) Collaborator (PI: Crott, JW)

Folate, DNA methylation, and carcinogenesis in the bowel NCI, R01 CA59005-S1 Mason Lab: $301,790.00 11/1998-10/2004 (NCE) Co-Investigator (PI: Baron, J, Dartmouth Medical School) One-carbon nutrients in cancer prevention NCI, K05 CA100048 $613,079.00 (total direct costs) 09/2003-02/2009 (NCE)

Principal Investigator

Phase 1 Clinical pharmacodynamic study of folate NCI, N01 CN35111 Mason Subcontract: $71,680.00 09/01/2005-08/31/2007. Co-Investigator (PI: Marshall J, Roswell Park Cancer Institute) Mitochondrial and nuclear DNA damage in folate-depleted colonic cells Cancer Research & Prevention Foundation $70,000.00 07/2004-06/2006 Principal Investigator Brief description of earlier grant history: My success in securing NIH grants began during my fellowship, when I obtained an individual F32 training grant to study intestinal folate absorption (1986-88) and it continued into my years as a junior faculty member, when I secured a U-01 from the NCI (1994-98) to serve as the P.I. for the Eastern Cooperative Oncology Group's very first cancer chemoprevention trial. Interspersed amongst these NIH grants have been those secured from other non-profit granting agencies for which I have been the P.I.: the American Gastroenterological Association; the International Life Science Institute; and the American Institute for Cancer Research.

EDITORIAL BOARDS AND ACTIVITY

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Editorial advisor, Human Pathology, 1988-2000

Member, editorial board, Journal of Parenteral and Enteral Nutrition, 1991-2005 Member, editorial board, Nutrition in Clinical Care, 1997-2006

Co-editor, Nutrition & Cancer: Prevention and Treatment, JB Mason; G Nitenberg, eds, Nestle Nutrition Workshop Series Clinical & Performance Programme, vol 4, Nestec Ltd.; (Vevey, Switzerland), S. Karger AG, 2000 Guest editor, Nutrition and Clinical Care, December 2004 issue Member, editorial board, Journal of Nutrition and Metabolism, 2009-2014 Member, Editorial Board, Frontiers in Nutrigenomics, 2010-present Member, Editorial Board, Tufts Health and Nutrition Newsletter, 2011-present

EXTRAMURAL INVITED LECTURESHIPS (since 2005) National Folate Awareness Week, 2005 folate in the prevention National Press Club, Washington of chronic disease D.C.

CME Conference on Geriatric 2005 Nutrition and aging Medicine, Harvard Medical School, Boston

Conference on Nutrition and 2005 Nutrition in Aging, Dartmouth Medical School the elderly Hanover, NH

4th International Homocysteine Conference, 2005 One-carbon nutrients as Milan, ITALY modulators of carcinogenesis

Epithelial Carcinogenesis Seminar, 2005 folate and cancer Rockefeller University, NYC

Annual AACR Frontiers in Cancer 2006 One-carbon nutrients and Prevention Research Conference, Boston cancer prevention

Urological Cancers Research Seminar 2007 One-carbon nutrients in University of Pittsburgh, Pittsburgh, PA cancer prevention

Debate on folate content of multivitamins, 2007 folate and cancer Wyeth Home Pharmaceuticals, NJ

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Epigenetics and Cancer, NIH Conference, 2007 One-carbon nutrients and Bethesda, MD epigenetics

Nutrition in the Practice of Gastroenter- 2007 1. Nutritional management of ology, American Gastroenterological the cancer patient Association Postgraduate Education 2. Nutrition in the elderly Course, Chicago, IL

Office of Dietary Supplements, NIH, 2007 folic acid fortification and Research Conference, Bethesda, MD supplements: effects on

colorectal cancer risk

New York Review Course for 2008 topics in Clinical Nutrition the Board Exam in Gastroenterology, for gastroenterologists NJ

Plenary Session, Annual Meeting of 2008 folate and cancer the American Institute for Cancer Research (AICR), Washington D.C.

GTC 2nd Annual Conference on 2008 folate and cancer Rediscovering Biomarkers, Boston, MA

3rd Annual Friedman School of Nutrition 2008 folate and colon cancer Symposium: ‘Nutrition Agenda 2008 & Beyond’, Boston, MA

Pathobiology Seminar, University of 2009 folate and cancer Connecticut, Storrs, CT

Annual Nutracon Meeting, (an 2009 folate and cancer international consortium of industries that manufacture nutritional products), Anaheim, CA

Hebrew University School of Nutrition, 2009 folate and cancer 40th Year Anniversary Symposium,

Keynote Speaker, Jerusalem, ISRAEL American College of Nutrition, 2009 folate and cancer Annual Meeting, Keynote Speaker, Orlando, FL

Université Clermonte-Ferrand, 2009 folate and cancer Clermont-Ferrand, FRANCE

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Longwood Seminar on Clinical Nutrition, 2009 folate and cancer Harvard Medical School, Boston, MA

FASEB Summer Conference on B12, 2010 folate and cancer Folate and One-carbon Metabolism, Carefree, AZ American Society of Nutrition, Advances 2011 folate and cancer And Controversies in Clinical Nutrition, San Francisco, CA

Symposium on Folic Acid: An update 2011 folate and cancer Universitas Bio-Medica di Roma, Rome, ITALY Guest lecturer in ‘Scientific Basis 2011 folate and cancer of Human Nutrition’, Boston University, Boston, MA Seminars in Cell Biology, Cleveland Clinic 2011 folate and cancer Lerner Research Institute, Cleveland, OH Medical Grand Rounds, Boston University 2012 folate and cancer Medical Center, Boston, MA

Molecular Medicine Institute, Univ of CT 2012 folate and cancer Farmington, CT

Advances and Controversies in B-vitamins 2012 folate and cancer

and Choline, Leipzig, GERMANY Nutrition and Exercise in the Management 2012 Chairperson of meeting and of Outpatients: Important Advances You 3 lectures Need to Know, Boston MA Medical Grand Rounds, Robert Wood 2013 nutrition in cancer Johnson Medical School, New Brunswick, NJ prevention Guest lecturer in ‘Scientific Basis 2013 folate and cancer of Human Nutrition’, Boston University, Boston, MA Visiting Professor, University of 2013 obesity and carcinogenesis Pittsburgh Cancer Center, Pittsburgh, PA Medical Grand Rounds, Lawrence 2014 probiotics in clinical care

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Memorial Hospital, Medford, MA Guest lecturer in ‘Scientific Basis 2014 folate and cancer of Human Nutrition’, Boston University, Boston, MA American Institute for Cancer 2014 folate and cancer Research, annual meeting, Washington D.C. (Chairperson of Plenary session) Advances and Controversies in Clinical 2014 micronutrients in cancer Nutrition (Am. Soc. Nutr), Nat’l Harbor, MD prevention (Co-Chairperson of Conference) European Society of Parenteral and 2015 pathways by which obesity Enteral Nutrition, Annual Meeting promotes cancer (Lisbon, Portugal) BIBLIOGRAPHY Original Research: 1. Campbell C, Mason JB, Wieler J. Continuous infusion of subcutaneous morphine in

reducing the pain of terminal malignancy. Ann Int Med 1983;98: 51-2. 2. Percy W, Roberts R, Mason JB, Christensen J. Substrate dependence and oxygen sensitivity

of tone and of spontaneous and evoked contractions of the distal colonic muscularis mucosae of oppossum. Gastroenterology 1986;91: 570-5.

3. Mason JB, Selhub J. Folate-binding protein and the small intestinal absorption of folic acid in the neonatal rat. Am J Clin Nutr 1988;48: 620-5.

4. Mason JB, Shoda R, Haskell M, Selhub J, Rosenberg IH. Carrier affinity as a mechanism for the pH-dependence of folate transport in the small intestine. Biochim Biophys Acta 1990;1024: 331-5.

5. Shoda R, Mason JB, Selhub J, Rosenberg IH. Folate binding in intestinal brush border membranes: evidence for the presence of two activities. J Nutr Biochem 1990;1: 257-71.

6. Mason JB, Zimmerman J, Otradovec CL, Selhub J, Rosenberg IH. Chronic diuretic therapy with moderate doses of the folate antagonist, triamterene, is not associated with folate deficiency. J Lab Clin Med 1991;117: 365-9.

7. Cravo M, Mason JB, Selhub J, Rosenberg IH. Use of deoxyuridine suppression test to evaluate localized folate deficiency in rat colonic epithelium. Am J Clin Nutr 1991;53: 1450-54.

8. Kowdley K, Mason JB, Meydani S, Cornwall S, Grand R. Vitamin E deficiency and impaired cellular immunity related to fat malabsorption. Gastroenterology 1992;102: 2139-42.

9. Cravo M, Mason JB, Dayal Y, Hutchinson M, Smith D, Selhub J, Rosenberg IH. Folate deficiency enhances the development of colonic neoplasia in dimethylhydrazine-treated rats. Cancer Res 1992;52: 5002-6.

10. Lennon C, Davidson K, Sadowski J, Mason JB. The vitamin K content of intravenous lipid emulsions. J Parent Ent Nutr 1993;17: 142-144.

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11. Zheng J, Mason JB, Rosenberg IH, Wood R. Measurement of zinc bioavailability from beef and a ready-to-eat high fiber breakfast cereal in humans: application of a whole gut lavage technique. Am J Clin Nutr 1993;58: 902-7.

12. Kim Y, Giuliano A, Hatch K, Schneider A, Nour M, Dallal G, Selhub J, Mason JB. Global DNA hypomethylation increases progressively in cervical dysplasia and carcinoma. Cancer 1994;74: 893-9.

13. Kim Y, Miller J, da Costa K, Nadeau M, Smith D, Selhub J, Zeisel S, Mason JB. Folate deficiency causes secondary depletion of choline and phosphocholine in rat liver. J Nutr 1994;124: 2197-203.

14. Cravo M, Fidalgo P, Pereira A, Gouveia-Olivera A, Chaves P, Selhub J, Mason JB, Mira F, Leitao C. DNA methylation as an intermediate biomarker in colorectal carcinogenesis: modulation by folic acid. Euro J Cancer Prevent 1994; 3:473-9.

15. Kim Y-I, Christman J, Fleet J, Cravo M, Saloman R, Smith D, Ordovas J, Selhub J, Mason JB. Moderate folate deficiency does not cause global hypomethylation of hepatic and colonic DNA or c-myc specific hypomethylation of colonic DNA in rats. Am J Clin Nutr 1995;61: 1083-90.

16. Kim Y-I, Logan J, Mason JB, Roubenoff R. DNA hypomethylation in inflammatory arthritis: reversal with methotrexate. J Lab Clin Med 1996;128: 165-72.

17. Camilo E, Zimmerman J, Mason JB, Golner B, Russell R, Selhub J, Rosenberg IH. Folate synthesized by bacteria in the upper small intestine of the human is assimilated by the host. Gastroenterology 1996;110: 991-8.

18. Kim Y-I, Pogribny I, Salomon R, Choi S, Smith D, James SJ, Mason JB. DNA hypomethylation of the p53 gene of rat colon induced by dimethylhydrazine: modulation by dietary folate. Am J Pathol 1996;149: 1129-37.

19. Kim Y-I, Salomon R, Graeme-Cook F, Choi S, Smith D, Nadeau M, Dallal G, Mason JB. Dietary folate protects against the development of macroscopic colonic neoplasms in a dose responsive manner in the dimethylhydrazine rat model. Gut 1996;39: 732-40.

20. Zhu S-S, Hu Y-B, Shi Y, Mason JB, Xiao S-D. Reversion of precancerous lesions of gastric cancer with some vitamins: preliminary clinical observations. Chinese J Gastro 1996; 1:70-4.

21. Kim Y-I, Pogribny I, Basnakian A, Miller J, Selhub J, James SJ, Mason JB. Folate deficiency in the rat induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene. Am J Clin Nutr 1997; 65: 46-52.

22. Jatoi A, Hansjosten K, Ross E, Mason JB. A prospective survey for central line skin-site colonization by the pathogen, M. furfur, among hospitalized adults receiving total parenteral nutrition. J Parent Ent Nutr 1997; 21:230-2.

23. Camilo E, Jatoi A, O’Brien M, Davidson K, Sokoll L, Sadowski J, Mason JB. Bioavailability of phylloquinone from an intravenous lipid emulsion. Am J Clin Nutr 1998;67: 716-21.

24. Choi S, Kim Y-I, Weitzel J, Mason JB. Folate depletion impairs DNA excision repair in the colon of the rat. Gut 1998;43: 93-99.

25. Kim Y-I, Fawaz K, Knox T, Lee Y-M, Norton R, Arora S, Paiva L, Mason JB. Colonic mucosal concentrations of folate correlate well with blood measurements of folate status in individuals who harbor colorectal polyps. Am J Clin Nutr 1998;68: 866-72.

26. Jatoi A, Daly B, Kramer G, Mason JB. A cross-sectional study of vitamin intake in post-operative non-small cell lung cancer patients. J Surg Oncol 1998;68: 231-6.

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27. Homocysteine Lowering Trialist’s Collaboration. Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. Br Med J 1998;316: 894-8.

28. Jatoi A, Lennon C, Davidson K, Sadowski J, Mason JB. Protein-calorie malnutrition does not predict subtle vitamin K depletion in hospitalized patients. Eur J Clin Nutr 1998;52: 984-7.

29. Yeum K-J, Lee-Kim Y, Zhu S, Xiao S, Mason JB, Russell R. Serum concentrations of antioxidant nutrients in American, Chinese and Korean healthy adults. Asia Pacific J Clin Nutr 1999;8: 4-8.

30. Choi S-W, Stickel F, Baik H, Kim Y-I, Seitz H, Mason JB. Chronic alcohol consumption induces genomic, but not p53-specific, DNA hypomethylation in rat colon. J Nutr 1999;129: 1945-50.

31. Sohn K-J, Puchyr M, Salomon R, Graeme-Cook F, Fung L, Choi S-W, Mason JB, Medline A, Kim Y-I. The effect of dietary folate on apc and p53 mutations in the DMH rat model of colorectal cancer. Carcinogenesis 1999;20: 2345-50.

32. Kim Y-I, Shirwadkar S, Choi S-W, Puchyr M, Wang Y, Mason JB. Effects of dietary folate on DNA strand breaks within mutation-prone exons of the p53 gene in rat colon. Gastroenterology 2000;119: 151-61.

33. Stickel F, Choi SW, Kim Y-I, Bagley P, Seitz H, Russell R, Selhub J, Mason JB. Effect of chronic alcohol consumption on total plasma homocysteine level in rats. Alcoholism: Clin Exp Res 2000;24: 259-64.

34. Lathrop-Stern L, Mason JB, Selhub J, Choi S-W. Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene. Cancer Epidemiol Biomarkers Prevent 2000;9: 849-53.

35. Song J, Medline A, Mason JB, Gallinger S, Kim YI. Effects of dietary folate on intestinal tumorigenesis in the apcmin mouse. Cancer Res 2000;60: 5434-40.

36. Woodson K, Mason J, Choi SW, Taylor PR, Virtamo J, and Albanes D. Hypomethylation of p53 in peripheral blood DNA is associated with the development of lung cancer. Cancer Epidemiol Biomarkers Prevent 2001;10: 69-74.

37. Kim Y-I, Baik H, Fawaz K, Knox T, Lee Y-M, Norton R, Libby E, Mason JB. Effects of folate supplementation on two provisional molecular markers of colon cancer: a prospective, randomized trial. Am J Gastro 2001;96: 184-95.

38. Kim Y-I, Fawaz K, Knox T, Lee Y-M, Norton R, Libby E, Mason JB. Colonic mucosal concentrations of folate are accurately predicted by blood measurements of folate status among individuals ingesting physiologic quantities of folate. Cancer Epidemiol Biomarkers Prevent 2001;10: 715-9.

39. Jatoi A, Daly B, Kramer G, Mason JB. Folate status among patients with non-small cell cancer: a case-control study. J Surg Oncol 2001;77: 247-52.

40. Friso S, Choi SW, Girelli D, Mason JB, Dolnikowski G, Bagley P, Olivieri O, Jacques P, Rosenberg IH, Corrocher R, Selhub J. A common mutation in the 5,10 methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proceed Natl Acad Sci USA 2002;99: 5606-11.

41. Kim Y-I, Hayek M, Mason JB, Meydani S. The effect of folate deficiency on natural killer cell-mediated cytotoxicity. J Nutr 2002;132: 1361-7. \

42. Ghandour H, Lin B-F, Choi S-W, Mason JB, Selhub J. Folate status and age affect the accumulation of L-isoaspartyl residues in rat liver proteins. J Nutr 2002;132: 1357-60.

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43. Sohn K-J, Stempak JM, Reid S, Shirwadkar S, Mason JB, Kim Y-I. The effect of dietary folate on genomic and p53-specific DNA methylation in rat colon. Carcinogenesis 2003;24: 81-90.

44. Choi S-W, Friso S, Dolnikowski G, Bagley P, Edmondson A, Nadeau M, Smith D, Mason JB. Biochemical and molecular aberrations in the rat colon due to folate depletion are age-specific. J Nutr 2003;133: 1206–12.

45. Chung H, Wu D, Han SN, Gay R, Goldin B, Bronson R, Mason JB, Smith D, Meydani S. Vitamin E supplementation does not alter azoxymethane-induced colonic aberrant crypt foci formation in young or old mice. J Nutr 2003;133: 528-32.

46. Zhu S, Mason J, Shi Y, Hu Y, Li R, Wahg M, Zhou Y, Jin G, Xie Y, Wu G, Xia D, Qian Z, Sohg H, Zhang L, Russell R, Xiao S. The effect of folic acid on the development of stomach and other gastrointestinal cancers. Chinese Med J (Engl). 2003;116: 15-9.

47. Chung H, Wu D, Gay R, Han S-N, Goldin B, Bronson R, Mason J, Smith DE, Meydani S. Effect of Age on Susceptibility to Azoxymethane-Induced Colonic Aberrant Crypt Foci Formation in C57BL/6JNIA mice. J Gerontol A Biological Sci Med Sci 2003;58: B400-5.

48. Crott JW, Choi SW, Orodovas JM, Ditelberg JS, Mason JB. Effects of dietary folate and aging on gene expression in the colonic mucosa of rats: implications for carcinogenesis. Carcinogenesis 2004;25: 69-76.

49. Waly M, Olteanu H, Banerjee R, Choi S-W, Mason JB, Parker B, Sukumar S, Shim S, Sharma A, Benzecry1 J, Power-Charnitsky V-A, Deth R. Activation of Methionine Synthase by Insulin-like Growth Factor-1 and Dopamine: A Target for Neurodevelopmental Toxins and Thimerosal. Molec Psychiatr 2004;9: 358-70.

50. Choi S-W, Friso S, Ghandour H, Bagley P, Selhub J, Mason JB. Vitamin B12 deficiency induces anomalies of base substitution and methylation in the DNA of rat colonic epithelium. J Nutr 2004;134: 750-5.

51. Crott JW, Choi S-W, Branda RF, Mason JB. Accumulation of mitochondrial DNA deletions is age, tissue and folate-dependent in rats. Mutation Research 2005;570: 63-70.

52. Moxon D, Raza M, Kenney R, Ewing R, Arozullah A, Mason JB, Carroll R. Aging and tobacco use are linked to the development of aberrant crypt foci (ACF) in a predominately African-American population. Clin Gastroenterol and Hepatol 2005;3: 271-8.

53. Choi S-W, Friso S, Keyes MK, Mason JB. Folate supplementation increases genomic DNA methylation in the liver of elder rats. Br J Nutrition 2005;93: 31-5.

54. Homocysteine Lowering Trialist’s Collaboration. Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials. Am J Clin Nutr 2005;82: 806-812.

55. Gabriel HE, Crott JW, Ghandour H, Dallal GE, Choi S-W, Keyes MK, Jang H, Liu Z, Nadeau

M, Johnston A, Mager D, Mason JB. Chronic cigarette smoking is associated with diminished folate status, altered folate form distribution and increased genetic damage in the buccal mucosa of healthy adults. Am J Clin Nutr 2006;83: 835-41.

56. Yang A, Doshi K, Choi S-W, Mason JB, Mannari R, Gharybian V, Shen L, Estecio M, Garcia-Manero G, Kantarjian H, Issa J-P. Methylation changes in leukemia patients treated with 5-aza-2'-deoxycytidine (Decitabine). Cancer Res 2006;66: 5495-503.

57. Gabriel H, Liu Z, Crott J, Choi S-W, Song B, Mason JB, Johnson EJ. A comparison of carotenoids, retinoids and tocopherols in the serum and buccal mucosa of chronic cigarette smokers versus non-smokers. Cancer Epidemiol Biomarkers Prevent 2006;15: 993-9.

58. Crott J, Liu Z, Mason JB. Folate depletion in human lymphocytes up-regulates p53

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expression despite marked induction of strand breaks in exons 5–8 of the gene. Mutation Res 2007;626: 171-9.

59. Keyes MK, Jang H, Mason JB, Liu Z, Crott J, Smith D, Friso S, Choi S-W. Elder age and dietary folate are determinants of genomic and p16-specific DNA methylation in the mouse colon. J Nutr 2007;137: 1713-7.

60. Mason JB, Dickstein A, Jacques P, Haggarty P, Selhub J, Dallal G, Rosenberg IH. A temporal association between folic acid fortification and a rise in colorectal cancer rates may be illuminating important biological principles: a hypothesis. Cancer Epidemiol Biomarkers Prevent 2007;16: 1-5

61. van den Donk M, Pellis L, Crott J, van Engeland M, Friederich P, Vallei Ede G, Y. de Boer S, Nagengast F, Mason JB, Kok F, Keijer J, Kampman E. Supplementation with folic acid in combination with vitamin B-12 does not favorably influence uracil incorporation and promotor methylation in rectal mucosa DNA among those with previous colorectal adenomas. J Nutr 2007;137: 2114-20.

62. Liu Z, Choi S-W, Crott JW, Keyes MK, Jang H, Smith D, Kim M, Laird PW, Bronson R, Mason JB. Mild Depletion of Dietary Folate Combined with Other B-vitamins Alters Multiple Components of the Wnt Pathway in Mouse Colon. J Nutr 2007;137: 2701-8.

63. Keyes MK, Jang H, Mason JB, Liu Z, Crott JW, Smith D, Friso S, Choi S-W. Elder age and dietary folate are determinants of genomic and p16-specific DNA methylation in mouse colon. J Nutr 2007;131(7):1713-7.

64. Liu Z, Choi S-W, Crott JW, Smith D, Mason JB. 2008. Multiple B-vitamin inadequacy amplifies alterations induced by folate depletion in p53 expression and its downstream effector MDM2. Int J Canc 2008 123(3):519-25. NIHMSID: NIHMS146703.

65. DeVos L, Chanson A, Liu Z, Ciappio ED, Parnell LD, Mason JB, Tucker KL, Crott JW. Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrations. Am J Clin Nutr 2008;88: 1149-58. NIHMSID: NIHMS103704.

66. Crott JW, Liu Z, Keyes MK, Choi SW, Jang H, Moyer MP, Mason JB. Moderate folate depletion modulates the expression of selected genes involved in cell cycle, intracellular signaling, and folate uptake in human colonic epithelial cell lines. Journal of Nutr Biochem 2008;19(5): 328-35. PMCID: PMC2759072.

67. Chanson A, Parnell LD, Ciappio ED, Liu Z, Crott JW, Tucker KL, Mason JB. Polymorphisms in uracil-processing genes, but not one-carbon nutrients, are associated with altered DNA uracil concentrations in an urban Puerto Rican population. Am J Clin Nutr 2009;89 [ePub ahead of print April 29, 2009 as doi: 10.3945/ajcn.2009.27429].

68. Heseker HB, Mason JB, Selhub J, Rosenberg IH, Jacques PF. Not all cases of neural-tube defect can be prevented by increasing the intake of folic acid. Br J Nutr. 2009 Jul;102(2):173-80. PMID: 19079944

69. Sauer J, Jang H, Zimmerly EM, Kim KC, Liu Z, Chanson A, Smith DE, Mason JB, Friso S, Choi S-W. Ageing, chronic alcohol consumption and folate are determinants of genomic DNA methylation, p16 promoter methylation and the expression of p16 in the mouse colon. Br J Nutr. 2010:1-7. PMID: 20205967

70. Flood A, Mason JB, Zhenhua L, Cash BD, Schatzkin A, Schoenfeld PS, Cross AJ. Concentration of folate in colorectal tissue biopsies predicts prevalence of adenomatous polyps. Gut. 2011; 60: 66-72.

71. Protiva P, Mason JB, Liu Z, Hopkins ME, Nelson C, Marshall JR, Lambrecht RW, Pendyala S, Kopelovich L, Kim M, Laird PW, Lipkin M, Holt PR. Altered folate availability modifies

21

the molecular environment of the human colon: implications for colorectal carcinogenesis. Cancer Prev Res (Phila). 2011;4: 530-43.

72. Tomaszewski JJ, Cummings JL, Parwani AV, Dhir R, Mason JB, Nelson JB, Bacich DJ, O’Keefe DS. Increased cancer cell proliferation in prostate cancer patients with high levels of serum folate. Prostate. 2011;71: 1287-93. Epub 2011 Feb 9.

73. Ciappio ED, Liu Z, Brooks RS, Mason JB, Bronson RT, Crott JW. Maternal B vitamin supplementation from preconception through weaning suppresses intestinal tumorigenesis in Apc1638N mouse offspring. Gut. 2011;60: 1695-702. PMID: 21659408

74. Liu Z, Ciappio ED, Crott JW, Brooks RS, Nesvet J, Smith DE, Choi S-W, Mason JB. Combined inadequacies of multiple B vitamins amplify colonic Wnt signaling and promote intestinal tumorigenesis in BAT-LacZxApc1638N mice. FASEB J. 2011;25: 3136-45. PMID: 21646397

75. Marian C, Tao M, Mason JB, Goerlitz DS, Nie J, Chanson A, Freudenheim JL, Shields PG. Single nucleotide polymorphisms in uracil-processing genes, intake of one-carbon nutrients and breast cancer risk. Eur J Clin Nutr. 2011;65: 683-9. Epub 2011 Mar 23. PMID: 21427733

76. Tao MH, Mason JB, Marian C, McCann SE, Platek ME, Millen A, Ambrosone C, Edge SB, Krishnan SS, Trevisan M, Shields PG, Freudenheim JL. Promoter methylation of E-cadherin, p16, and RAR-β(2) genes in breast tumors and dietary intake of nutrients important in one-carbon metabolism. Nutr Cancer. 2011;63: 1143-50.

77. Liu Z, Brooks RS, Ciappio ED, Kim SJ, Crott JW, Bennett G, Greenberg AS, Mason JB. Diet-induced obesity elevates colonic TNF-α in mice and is accompanied by an activation of Wnt signaling: a mechanism for obesity-associated colorectal cancer. J Nutr Biochem. 2012;23: 1207-13.

78. Selhub J, Byun A, Liu Z, Mason JB, Bronson R, Crott J. Dietary Vitamin B6 intake modulates colonic inflammation in the IL10−/− model of inflammatory bowel disease. J Nutr Biochem 2013;24: 2138-43.

79. Byun A, Hung K, Fleet J, Bronson R, Mason JB, Garcia P, Crott J. Colon-specific tumorigenesis in mice driven by cre-mediated inactivation of Apc and activation of mutant k-ras. Cancer Letters, 2014;347: 191-5.

80. Bird J, Ronnenberg A, Choi S-W, Du F, Mason JB, Liu Z. Obesity Is Associated with Increased Red Blood Cell Folate Despite Lower Dietary Intakes and Serum Concentrations. J Nutr 2014;145: 79–86.

81. Llanos A, Dumitrescu R, Brasky T, Liu Z, Mason JB, Marian C, Makambi K, Spear S, Kallakury B, Freudenheim J, Shields PB. Relationships among folate, alcohol consumption, gene variants in one-carbon metabolism and p16INK4a methylation and expression in healthy breast tissues. Carcinogenesis 2015; 36:60-7.

82. Llanos A, Marian C, Brasky T, Dumitrescu R, Liu Z, Mason JB, Makambi K, Spear S, Kallakury B, Freudenheim J, Shields P. Associations between genetic variation in one-carbon metabolism and LINE-1 DNA methylation in histologically normal breast tissues. Epigenetics 2015;10(8):727-35.

83. Sabet J, Park L, Iyer LK, Tai A, Mason JB, Liu Z, Byun A, Parnell L, Crott J. Diet- and genetically-induced obesity differentially affect the fecal microbiome and metabolome in Apc1638N mice. PLoS One, 2015, 2015 Aug 18;10(8):e0135758

Book Chapters/Reviews:

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1. Rosenberg IH, Mason JB. Hepatobiliary Influences on the Skeletal System. In: Arias, I. The Liver: Biology and Pathobiology, 2nd edition. New York: Raven Press. 1988. pp. 1063-71.

2. Mason JB. Folate, Colitis, Dysplasia, and Cancer. Nutr Rev 1989;47: 314-7. 3. Mason JB, Rosenberg IH. Total Parenteral Nutrition in the Management of Inflammatory

Bowel Disease. In: Zimmerman J, Rachmilewitz D Inflammatory Bowel Diseases. Dordrecht: Kluwer Academic Publishers.1990. pp. 159-166.

4. Mason JB, Rosenberg IH. Nutritional Management of Inflammatory Bowel Disease. In: Allan R et al. Inflammatory Bowel Diseases, 2nd edition. London, England: Churchill Livingstone. 1990. pp. 411-20.

5. Mason JB, Rosenberg IH. Protein-Energy Malnutrition. In: Wilson J et al. Harrison's Principles of Internal Medicine, 12th ed. New York: McGraw-Hill. 1990. pp. 406-11.

6. Mason JB. Intestinal Transport of Monoglutamyl Folates in Mammalian Systems. In: Picciano MF, Gregory JF, Stokstad ELR. Folic Acid Metabolism in Health and Disease. New York: Alan R. Liss, Inc.1990. pp. 47-63.

7. Mason JB, Rosenberg IH. Folate and Vitamin B12. In: Mahmoud, A and Warren, KS. Tropical and Geographic Medicine, 2nd ed. New York: McGraw-Hill. 1990. pp. 1040-50.

8. Rosenberg IH, Mason JB, Knowles J. The Spectrum of Metabolic Bone Disease in Illnesses of the Small Bowel. In: Gasbarrini G et al Attualita. Gastroenterologia vol. 16. Bologna, Italy: Editrice Compositori, Bologna. 1991. pp. 41-6.

9. Saltzman J, Mason JB. Nutrition and the Elderly. Current Opinions in Gastroenterology, 1992; 8:307-13.

10. Mason JB, Miller J. The Effects of Vitamins B12, B6 and Folate on Blood Homocysteine Levels. In: Sauberlich H, Machlin L. Beyond Deficiency: New Views on the Function and Health Effects of Vitamins. Annals of the New York Academy of Sciences, vol. 669. 1992. pp. 197-204.

11. Mason JB. New Advances in the Chemoprevention of Colon Cancer: Folate and Colon Cancer. In: Jiang S, Xiao S. Proceedings of the 1992 Shanghai International Symposium on Gastroenterology. Shanghai: Shanghai Scientific and Technical Literature Publishers.1992. pp. 294-7.

12. Mason JB, Russell R. Parenteral Nutrition in the Elderly Individual. In: Rombeau J and Caldwell M. Clinical Nutrition, vol II: Parenteral Nutrition, 2nd ed. Philadelphia, PA: WB Saunders Co. 1993. pp. 737-47.

13. Rosenberg IH, Mason JB. Inflammatory Bowel Disease. In: Shils M, Young V. Modern Nutrition in Health and Disease, 8th ed. Philadelphia, PA: Lea and Febiger, 1994. pp. 1043-49.

14. Mason JB, Rosenberg IH. Protein-Energy Malnutrition. In: Wilson J et al. Harrison's Principles of Internal Medicine, 13th ed. New York: McGraw-Hill. 1994. pp. 440-46.

15. Mason JB, Rosenberg IH. Hepatobiliary Influences on the Skeletal System. In: ed. by Arias, I; The Liver: Biology and Pathobiology, 3rd edition. New York: Raven Press. 1994. pp.1257-66.

16. Mason JB, Rosenberg IH. Intestinal Absorption of Folate. In: Johnson L. Physiology of the Gastrointestinal Tract, 3rd edition. New York: Raven Press. 1994. pp. 1979-96.

17. Mason JB. Folate and Colonic Carcinogenesis: searching for a mechanistic understanding. J Nutr Biochem 1994; 5:170-5.

18. Mason JB. Vitamin and Mineral Supplementation in Inflammatory Bowel Disease. Practical

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Gastroenterology 1994;18: 18A-18H. 19. Mason, JB. Folate Status: Effects on Carcinogenesis. In: Bailey L. Folate in Health and

Disease. New York: Marcel Dekker, Inc. 1995, pp. 361-78. 20. Kim Y-I, Mason JB. Folate, Epithelial Dysplasia, and Colon Cancer. Proceed Assoc Am

Phys 1995;107: 218-27. 21. Saltzman E, Mason JB. Enteral Nutrition in the Elderly. In: Rombeau J and Caldwell M;

Clinical Nutrition, vol I: Enteral Nutrition, 3rd ed. Philadelphia, PA: WB Saunders Co. 1997, pp. 385-402.

22. Mason JB. Consequences of Altered Micronutrient Status. In: Bennett JC, Plum F. Cecil Textbook of Medicine, 20th ed. New York: WB Saunders Co.1996. pp. 1144-50.

23. Mason JB. The Modulation of Colorectal Carcinogenesis by Alterations in Folate Status: Epidemiology and Pathobiology. In: Mato J, Cabellaro A. Third International Workshop on Methionine Metabolism. Madrid, Spain: Consejo Superior de Investigaciones Cientificas.1996. pp. 96-109.

24. Kim Y-I, Mason JB. Nutritional Chemoprevention of Gastrointestinal Cancers. The Gastroenterologist 1996;4(suppl 1): S84-S106.

25. Mason JB, Levesque T. Folate: Effects on Carcinogenesis and the Potential for Cancer Chemoprevention. Oncology 1996;10: 1727-43.

26. Kim Y-I, Mason JB. Nutrition Chemoprevention of Gastrointestinal Cancers: a Critical Review. Nutrition Reviews 1996;54: 259-79.

27. Mason JB. Folate Status: Modulation of Colorectal Carcinogenesis. In: Graham I, Refsum H, Rosenberg IH, Ueland P. Homocysteine Metabolism: from Basic Science to Clinical Medicine. Norwell, MA: Kluwer Academic Publishers. 1997. pp. 167-76.

28. Mason JB. Folic acid and colon cancer: a potential for chemoprevention. Spanish J Community Nutr 1997;3(suppl): 57-61.

29. Choi S-W, Mason JB. Chemoprevention of colorectal cancer. Curr Opinions in Gastroenterology 1998;14: 173-8.

30. Jatoi A, Mason JB. An Approach to Nutritional Assessment. In: Brandt L. Clinical Practice of Gastroenterology. Philadelphia, PA: Current Medicine. 1999. pp.1557-66.

31. Mason JB, Selhub J. Disease prevention: broadening the definition of folate nutrition. Nutr Clin Care 1999;2: 82-6.

32. Mason JB, Kim Y-I. Nutritional strategies in the prevention of colorectal cancer. Curr Gastroenterology Reports 1999;1: 341-53.

33. Booth S, Nelson M, Mason JB, Angelo G, Meydani S. Dietary supplements for peri- and early postmenopausal women; a quantitative proposal based on disparities between recommendations and dietary intakes. Nutr Clin Care. 1999;2: 361-71.

34. Mason JB. Consequences of Altered Micronutrient Status. In: Bennett JC, Plum F. Cecil Textbook of Medicine, 21st edition. New York: WB Saunders Co. 2000. pp. 1170-78.

35. Choi S-W, Mason JB. Folate and carcinogenesis: an integrated scheme. J Nutr 2000;130: 129-32.

36. Mason JB. The Mechanisms by Which Folate Depletion Enhances Colorectal Carcinogenesis: a unified scheme. In: G Nitenberg, JB Mason. Nutrition and Cancer: Prevention and Treatment. Nestle Nutrition Workshop Series Clinical & Performance Programme, vol 4. Vevy, Switzerland: Nestec Ltd/ Basel Switzerland: S. Karger AG. 2000. pp. 87-102.

37. Mason JB, Choi S-W. Folate and carcinogenesis: developing a unifying hypothesis. Adv

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Enzyme Regul 2000;40: 127-41. 38. Choi S-W, Mason JB. Nutritional chemoprevention of colorectal cancer. Clin Perspectives

in Gastroenterology. 2000;3: 259-66. 39. Mason JB, Rasmussen H. Folate in the prevention of cancer. Nutrition & the M.D. 27(8):

1-4. 40. Mason JB. Vitamins and Trace Elements in the Critically Ill Patient. In: Shikora S,

Schwaitzberg S. Nutritional Considerations in the Intensive Care Unit. Dubuque, IA: Kendall-Hunt. 2002. pp. 61-78.

41. Gastrointestinal Cancer: Nutritional Support. Mason JB, Choi S-W. In: Kelsen D, Daly J, Kern S, Levin B, Tepper J. Principles and Practice of Gastrointestinal Oncology. Philadelphia, PA: Lippincott Williams & Wilkins. 2002. pp. 127-142.

42. Mason JB. Diet, folate and colon cancer. Current Op Gastroenterology 2002;18: 229-34. 43. Mason JB. Nutritional chemoprevention of colon cancer. Seminars Gastrointestinal Dis

2002;13: 143-53. 44. Choi S-W, Mason JB. Folate status: effects on pathways to colorectal carcinogenesis. J Nutr

2002;132: 2413S-2418S. 45. Mason JB. Biomarkers of nutrient exposure and status in one-carbon (methyl) metabolism.

J Nutr. 2003; 133: 941S-9417S. 46. Choi S-W, Mason JB. Nutrition and colon cancer. In: Caballero B. Trugo L, Finglas P.

Encyclopedia of Food Sciences and Nutrition. London, England: Elsevier Science Ltd. 2003. pp. 1543-50.

47. Mason JB, Choi S-W. Nutritional assessment and management of the cancer patient. In: Bronner F. Nutritional Aspects and Clinical Management of Chronic Disorders and Diseases. Boca Raton, FL: CRC Press. 2003. pp. 197-224.

48. Mason JB. Consequences of Altered Micronutrient Status. In: Goldman L, Ausiello D. Cecil Textbook of Medicine, 22nd edition. Philadelphia, PA: WB Saunders Co. 2004. pp. 1326-35.

49. Crott J, Mason JB. MTHFR Polymorphisms and Colorectal Neoplasia. In Ueland P, Rozen R. MTHFR Polymorphisms and Disease. Georgetown, TX: Landes Bioscience. 2005. pp. 179-96.

50. Mason JB, Choi SW. The effects of alcohol on folate metabolism: implications for carcinogenesis. Alcohol 2005;35: 235-41.

51. Jang H, Mason JB, Choi SW. Genetic and Epigenetic Interactions between Folate and Aging in Carcinogenesis. J Nutr. 2005;135: 2967S-71S.

52. Mason JB. Nutritional Assessment and Management of the Malnourished Patient. In: Feldman M, Friedman L, Brandt L. Sleisinger and Fordtran’s Gastrointestinal and Liver Disease, 8th ed. Philadelphia, PA: Elsevier. 2006. pp. 319-56.

53. Neff L, Mason JB. Nutrition in the Elderly. In: Clinical Nutrition in Gastrointestinal Disease. ed. Buchman AL. Thorofare, NJ: Slack Inc. 2006. pp.165-82.

54. Mason JB. Principles and Practice of Gastrointestinal Cancer: Nutritional Support. In: Kelsen DP. Principles and Practice of Gastrointestinal Oncology. 2nd Edition. Lippincott Williams & Wilkins. 2007. pp. 87-101.

55. Mason JB. Vitamins, Trace Minerals, and Other Micronutrients. In: Goldman L, Ausiello D. Cecil Textbook of Medicine 23rd Edition. Philadelphia, PA: Saunders Elsevier. 2007. pp. 1626-39.

56. Mason, JB. Choi SW, Liu Z. Other 1-carbon micronutrients and age modulate the effects of folate on colorectal carcinogenesis. Nutrition Reviews 2008;66 Suppl 1: S15-7.

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57. Mason JB. Folate, cancer risk, and the greek god, Proteus: a tale of two chameleons. Nutrition Reviews 2009;67(4):206–212. NIHMSID: NIHMS144632.

58. Mason JB. Nutritional Assessment and Management of the Malnourished Patient. In: Sleisinger and Fordtran’s Gastrointestinal and Liver Disease, 9th ed. eds Feldman M, Friedman L, Brandt L. Elsevier. Philadelphia, PA. 2009. pp. 47-75.

59. Ciappio E, Mason JB. Folate and Cancer: mechanisms. In: Folate in Health and Disease, 2nd ed. ed. Bailey L. Taylor & Francis Group. 2009. pp. 235-262.

60. Sauer J, Mason JB, Choi SW. Too much folate: a risk factor for cancer and cardiovascular disease? Curr Opin Clin Nutr Metab Care. 2009 Jan;12(1):30-6 PMCID: PMC2790187

61. Christensen KE, Mason JB, Rozen R. Folate and Cancer Risk. In: Herrmann W, Obeid R. Vitamins in the Prevention of Human Diseases. Walter de Gruyter 2011, pp. 166-186.

62. Mason JB, Kim S. Revisiting the Goldilocks phenomenon: Folate and Colorectal Cancer Risk. Amer J Gastro 2010; 105:1914-1916.

63. Ciappio ED, Mason JB, Crott JW. Maternal one-carbon nutrient intake and cancer risk in offspring. Nutr Rev. 2011;69: 561-71.

64. Mason JB. Unraveling the complex relationship between folate and cancer risk. Biofactors. 2011;37: 253-60.

65. Mason JB. Vitamins, Trace Minerals, and Other Micronutrients. In: Goldman L, Ausiello D. Cecil Textbook of Medicine, 24th ed. Philadelphia, PA: Saunders Elsevier. 2012, pp. 1397-1405.

66. Mason JB. Mechanisms of Nutrient Absorption and Malabsorption, in: Up-To-Date, the most widely used web-based physician reference in the world. http://www.uptodate.com/contents/search, updated yearly.

67. Mason JB, Milovic V. Overview of the Treatment of Malabsorption, in: Up-To-Date, the most widely used web-based physician reference in the world. http://www.uptodate.com/contents/search, updated yearly.

68. Mason JB, Milovic V. Clinical Features and Diagnosis of Malabsorption, in: Up-To-Date, the most widely used web-based physician reference in the world. http://www.uptodate.com/contents/search, updated yearly.

69. Mason JB. Nutritional Principles and Assessment of the Gastroenterology Patient. In: Feldman M, Friedman L, Brandt L. Sleisinger and Fordtran’s Gastrointestinal and Liver Disease, 9th ed. Philadelphia, PA: Saunders Elsevier. 2016, pp. 57-82.

70. Mason JB. Vitamins, Trace Minerals, and Other Micronutrients. In: Goldman L, Ausiello D. Cecil Textbook of Medicine 24th Edition. Philadelphia, PA: Saunders Elsevier. 2015, pp. 1445-54.

71. Dickstein A, Mason JB. Nutrition and Gastrointestinal Cancer. In: Buchman A. Nutritional Care of the Patient with Gastrointestinal Disease. New York, NY: Taylor & Francis. 2015, in press.

Editorials/book reviews/letters: 1. Rosenberg IH, Mason JB. Folate, Dysplasia and Cancer. Gastroenterology 1989; 97: 502-3

[editorial]. 2. Mason JB, Roubenoff R. The unbearable lightness of being...a cirrhotic. Gastroenterology

1993; 105: 1911-4 [editorial]. 3. Mason JB. A clinical nutritionist's search for meaning: why should we bother to feed the

acutely ill, hospitalized patient? Nutrition 1996; 12: 279-81[editorial].

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4. Mason JB. The pervasive nature of nutritional issues: the need for increased awareness. The Gerontologist 1997; 37: 277-9 [book review & editorial].

5. Mason JB. Handbook of Nutrition in the Aged, 2nd edition. Am J Clin Nutr 1997; 65: 1904 [book review].

6. Mason JB. Folate and colon cancer: a fascinating puzzle we have yet to complete. Clinical Nutr 1998;17: 41-3 [editorial].

7. Choi S-W, Mason JB. Folate and colorectal carcinogenesis: is DNA repair the missing link? Am J Gastroenterology 1998;93: 2013-6 [editorial].

8. Roubenoff R, Lennon C, Mason JB, Rosenberg IH, Saltzman E. Total parenteral nutrition in the critically ill patient. J Am Med Assoc 1999; 282; 1424-5 [letter].

9. Mason JB. The relationship between nutrition and cancer: clearly important but far from understood. Nutr Clinical Care 2000; 3: 1-2 [editorial].

10. Mason JB. Nutrition and gastroenterology: a mutually supportive partnership. Nutr Clin Care. 2004;7: 91 [editorial].

11. Mason JB, Cole BF, Baron JA, Kim Y-I, Smith AD. Folic acid fortification and cancer risk: plea for objective evaluation of the evidence. Lancet 2008;371:1335-6 [letter].

12. Mason JB, Baron JA. Effects of Folic Acid Plus Vitamin B12 vs Placebo in Myocardial Infarction Survivors. J Am Med Assoc 2010; 304(16):1783 [letter].

13. Mason JB. Folate consumption and cancer risk: a confirmation and some reassurance, but we're not out of the woods quite yet. Am J Clin Nutr. 2011;94: 965-6.