curriculum vitae executive director creative bio-science · project management platform for...

Av.DelValleNorte857.Oficina102.CiudadEmpresarial.

Huechuraba,Santiago.CHILE.13-ene-17

Curriculumvitae

ManuelGidekelRUT14.645.268-KChileanExecutiveDirectorCreativeBio-ScienceAv.delValleNorte857.Office102Huechuraba,[email protected]:+569-99970216

Objective

Appliedresearch,innovationandtechnologymanagementaremypassionandlifemotif.Spendingsummers in the Antarctic Region has been a source of inspiration and self-criticism about theimpactofourresearchinChileandtheRegion.

Profile

Directorof37scienceandtechnologyapplicationprojectsinChile,hasgenerated28patentsandtrademarksintheU.S.and33ISIpublications.Founderin2001andDirectorofthePhDPrograminAppliedCellularandMolecularBiology,attheUniversityofLaFrontera,Chile(accreditedbytheCNAPin2006).Hasconducted17PhDthesisandcurrentlydirects1Post-doctorates.Creatorandfounder in 2003 of the Consortium for Technology and Health Innovation (CTI CTE-06, PBCT)-CONICYT, sponsored by the World Bank. Founder and director in 2007 of the VentureL@bresearchplatformattheAdolfoIbáñezUniversity.

Education

1986.Agronomist.UniversidadNacionaldeRosario,Argentina.

1996.PhD.Biotechnology.CINVESTAV.Irapuato,México

2000.Agronomist.UniversidaddeChile.Santiago,Chile



WorkExperience

1998March through 2015 December. Vice Rectory of Research and Postgraduate Studies. PhDProgram,mention inAppliedCellular&MolecularBiology.UniversidaddeLaFrontera,Temuco,Chile.

2007March through 2012 July. Executive Director, VentureLab. Business School, Adolfo IbáñezUniversity.Santiago,Chile.

2014.October.AssociateResearch.UniversidadAutonomadeChile.

2015.June.ResearchAssociate.UniversityofCalifornia,Davis.USA

ThesisDirectorof17PhDstudentsand3Masterdegreestudents

Awards

2014.IntellectualPropertyAward.UniversidaddeLaFrontera

2012.SeedProjectMITMISTIChile.Boston.EE.UU.

2012.FellowshipAUTMinTransferTechnology.UniversidaddeEmory.EE.UU.

2009.CYTED-IBEROEKAAwardTechnologicalInnovation.Spain.

2009.AVONNI.InnovationAward"WithoutFrontiers".ChileanMinistryofEconomy.

2007.FirstPrice.PatentsfortheSouthernWorld.

2004.AWARDFORINNOVATIONINTECHNOLOGYCOMPANYBASE.WorldBank-CONICYT.Awardfor outstanding contribution to creativity and technology-based entrepreneurship.BicentennialScienceandTechnologyofChile.

2003.AGRICULTURALINNOVATIONAWARD.(SustainabilityCategory)forin-vitromultiplicationof13copihuecultivars.MinistryofAgricultureofChile

1999. SPANISHSOCIETYAWARDPhytopathology. LatinAmericanAssociationofPhytopathology,Mexico

1995. International Scholarship "Cuauhtemoc" No. 82,035. National Council for Science andTechnology.C.O.N.A.C.Y.T.MEXICO.

1993.InternationalScholarshipattheUniversityoftheUnitedNations.Japan.



1991. Scholarship "Freedom from Hunger." ROTARY INTERNATIONAL. The Rotary Foundation.Evanston,Illinois.U.S.A.

1987. Scholarship Committee for Scientific Research for Agriculture. Campomar Foundation,BuenosAires,Argentina

ResearchProjects(since2000)

1998-2001. Study of sequential expression of adaptive mechanisms responsible for freezingtoleranceinDeschampsiaantarcticaDesv.FONDECYT1000610

2001-2003.StrengtheningthescientificandtechnologicalcapacityoftheUniversityofLaFrontera:Inter-universityDoctorateinPhysiologyandPlantMolecularBiology.AndesFoundation(C-13460-10)

2001-2003.NaturalcomparativestudyofgeneexpressioninDeschampsiaantarcticainlaboratoryandAntarcticconditions.INACH03-01

2001-2004.ElitefrostresistantEucalyptusglobulus.C7FTFDI-011.CORFO

2001-2002. Study of the genes regulation in Deschampsia Antarctica Desv, induced by coldconditions.Isolationandcharacterizationoftheirpromoterregions.FONDECYT2010076.

2002-2004. Developing strategies for mass multiplication of 13 copihues cultivars. Fondo deInnovaciónTecnológica.001-A1-013.INNOVA,BíoBío

2002-2004.TrainingforsmallfarmersandequipmentfororganicproductionofmedicinalplantsinRegionIX.FNDRBIP:20178301-0

2002-2004.IncreasedproductivityinEucalyptusglobulusplantationsinRegionsIXandXtoobtainelitetreesdefoliantsattackstolerantfungi(Mycosphaerellaspp).FDI01CR3-FT01

2002-2003. Isolation and characterization of the gene regulatory regions of tissue specificexpressionincalla(Zantedeschiaspp.).DIUFRO120202

2003-2004.Protocolforin-vitropropagationofseedlingsofArnicamontana,FondodeInnovaciónTecnológica,ProyectoSalusFutacoyan–Vitrogen.SA201-2934

2003-2004. Propagation and cultivation of orchids. A new alternative for the flower industry inChile.FondodeInnovaciónTecnológica01-A11-111.INNOVA,BíoBío.



2004. Undergraduate international Internships in High Technology Centers. 2004. FoundationAndes Foundation (C-13, 840). Flandes, Institute for Biotechnology, Universiteit Gent, Bélgica,Student:AdolfoSalvo.NationalTutor:ManuelGidekel.

2003-2004. Study of gene protein-protein interaction DaRub1 Deschampsia antarctica Desv.DIUFRO120418

2004-2008.DeschampsiaantarcticaDesv.StudyofgenesandUVsunscreenagents for itsuse inthepharmaceuticalindustry.D03I-1079FONDEF

2004-2008.LogisticSupport.FONDEFD03I-1079.ChileanAntarctic Institute.MinistryofExternalAffairs,Chile

2004-2006. NOVAPROTEC. NEOTEC. Ibero-American Ciencia y Tecnología para el Desarrollo(CYTED).Apoteknos-VitroGenSA.Madrid,España

2006-2008.DevelopmentandproductionofhydrolyticenzymesofDeschampsiaantarctica.04-B1-283L1INNOVABíoBío

2006-2013.TechnologyandHealthInnovationConsortium,CTI-SaludS.A.ProgramaBicentenariodeCienciayTecnología.PIACTE-06.WorldBank-CONICYT.$2.999.000.000

2006-2007."Workshopfornewventuredevelopment,ScienceandBusiness"UniversidadAdolfoIbáñez. Second contest to finance management and training In Science, Technology andInnovation.

2006-2010.INNOVA206-5668.ProductionofDeschampsiaantarcticacellsinbioreactors.Usesforcosmeticdermatologyascryoagentsandsunscreens.$404.000.000

2008.ProjectManagementPlatformforscientists.PBCT-BioCash

2008-2010.Antarctica:Sourceofbiological resourcesfornationalbiotechnology. INNOVACHILE,07CN13X-264

2010-2012.Developmentandapplicationof themethodology for the isolationofnewconsortiaand strains of microorganisms as inoculants for bioleaching processes. COPEC Foundation –CatholicUniversity,Chile.Cod6C005.

2009-2012. International intellectual property protection of new products: Deschampsiaantarcticaextractswithantineoplasticactivity.09APPI-6836



2009-2012.Internationalintellectualpropertyprotectionofnewproducts:photoprotectionagentagainstUVA-UVBrays.09APPI-6316.

2010-2011. The dissociation of uterine estrogen responses for therapeutic purposes inphytoestrogensandcancerprevention.PIA-CONICYTADI07ResearchRing2010

2010-2013.Newpsychrophilicbiofertilizer.10ETN-7396.CORFO.$180.000.000

2010 a 2014. Pre-clinical and clinical development of a viral vectors for colorectal cancertreatment.InnovaCORFO10IEI-7541.$310.499.000

2011.Thepreparationofworldclassspecialists intechnologytransferandmarketingofscience-basedtechnology.10AUTM-9003.CORFO

2011-2012. Functional Food Innovation Platform, FIC-R Gobierno Regional de Santiago.$168.000.000

2011-2012.MassmultiplicationtechnologyofYaretanativeplanttodevelopnutraceuticals.PYT-2011-0048.FundaciónparaInnovaciónAgraria.$134.000.000

2011-2013. “Akiles”handicapped rehabilitationdevice for assistedwalk andpatientmovement.INNOVACódigo11ETN-9413.$153.500.000

2011. Vaccine development for pigs and poultry out of a microorganism production platform.IncentivoTributarioCréditoI+D2011.SC0059.$100.000.000

2012-2013. 11OTLI-12096. Open University Platform - Business Technology Commercialization,OfficeofUniversidadAdolfoIbáñez$139.000.000

2012-2013.SyntheticBiologyProjectDesign.MITInternationalScienceandTechnologyInitiatives(MISTI).GlobalSeedFunds.

2012.12IDL1-13276–WoodBio-remediation.

2012-201512IDL2-13648.Newantineoplasicmolecule.UxmalS.A.$175.933.349

2012-2014 12IDL2-13610.New early diagnosis system of pancreatic cancer. CTI Salud S.A.$167.680.000

2016-2017.15ITE2-49635. FarmacomodulacióndeAntartina,nuevoagenteterapéuticodecáncerdecolonmetásticoyotrasenfermedadeshuérfanas.UxmalS.A.$79.100.000.-



Patents

1. 01189221 A1. 2007. Novel Plant Promoter. GIDEKEL, Manuel; GUTIERREZ, Ana; LEAL,Pamela;DESTEFANO-BELTRÁN,Luís;DINAMARCA,Jorge,GUERRAEmilio.Issue

2. PCT/US2008/010964. A novel superoxide dismutase gene and uses thereof. GIDEKEL,Manuel;GUTIERREZ,Ana;SANCHEZ,Jaime,CABRERA,Gustavo,RABERT,Claudia,

3. PCT/US08/12819. New extracts of Deschampsia antarctica Desv. with antineoplasticactivity. GIDEKEL Manuel, WEBER Helga, ANDANA Alejandra, CABRERA Gustavo,GUTIÉRREZ Ana, OSORIO Jennifer, BECERRA José, PODHAJCER Osvaldo, CAFFERATAEduardo,SUNKELCarlosyMIHOVILOVIC.NationalsPhaseinUSA,Canada,Europa(Issue),NewZeeland(Issue),Australia,Brazil&Japan.

4. PCT/US08/05131. US8415271-B2. Formulation of New Psychrophile Biofertilizers,GIDEKEL, Manuel; GUTIERREZ, Ana; CABRERA, Gustavo, BARRIENTOS, Leticia, BERRIOS,Graciela.Nationals Phases inUSA (Issue), Canada (Issue), New Zeeland (Issue), Europa(Issue)AustraliaandJapan.

5. PCT/ES2009-000050.Agentepara la FotoprotecciónCutánea frentea la radiaciónUVA-UVB. GIDEKEL, Manuel; GUTIERREZ, Ana; CABRERA, Gustavo, MOLINA Ramón, SUNKELCarlos. Nationals en USA, Canada, New Zeeland, Australia, Europa, Australia, Brazil &Japan.(Issue)

6. 20110195034.Usodeunacomposiciónquecontieneunextractodeunaplantagramíneaparalaprevencióndelesionescutáneasoriginadasporlaradiaciónultravioleta.GIDEKEL,Manuel;GUTIERREZ,Ana; CABRERA,Gustavo,MOLINARamón, SUNKELCarlos. (Issue) inSpain&USA.

7. 12/316,988 A novel gene and uses thereof. Lipase-sunscreen application. GIDEKEL,Manuel;GUTIERREZ,Ana;RABERT,Claudia,CABRERA,Gustavo,SANCHEZ, Jaime,BRAVO,León.(Issue)

8. 12/317,039.Anovelgeneanduses thereof.Wastewater.GIDEKEL,Manuel;GUTIERREZ,Ana;RABERT,Claudia,CABRERA,Gustavo,SANCHEZ,Jaime,BRAVO,León.(Issue)

9. US 7,485,455 B2. Plant gene and uses thereof. Gidekel, GIDEKEL, Manuel; GUTIERREZ,Ana;RABERT,Claudia,CABRERA,Gustavo,SANCHEZ,Jaime,BRAVO,León.(Issue)

10. C12N5/00 2798/CHE/2009 A. In-Vitro Propagation of Deschampsia antarctica -A FrostResistant Plant. PATELL, VILLOOMORAWALA, JAIN, RENUKA, DANAPUR, VIJAY, BAKHRI,VENUGOPAL,GIDEKIL,MANUEL,OSORIO,JENNIFER

11. CIP/12819.New extracts ofDeschampsia antarctica Desv. with antineoplastic activity.GIDEKELManuel,WEBERHelga, ANDANAAlejandra, CABRERAGustavo, GUTIÉRREZ Ana,OSORIO Jennifer, PODHAJCER Osvaldo, CAFFERATA Eduardo, SUNKEL Carlos &MIHOVILOVIC. Nationals Phases in USA (Issue), Canada, Europe, New Zeeland (Issue),Australia,BrazilyJapan(JPPatentApplicationNo.2010-534045(Issue)



12. Official USPTO Notification: OG Publication Confirmation for Serial Number 85556476.Antartina

13. 61/630,361. 13/694,381. US20140144080-A1. Production of Deschampsia antartica inBioreactors.GidekelManuel,OSORIOJennifer,SUNKELCarlos.(Issue)

14. 61/489885. US 13/506865 Pharmaceutical Kit And Method For Treating Cancer.PODHAJCER Osvaldo, GIDEKEL Manuel, CAFFERATA Eduardo, Helga Weber. (Issue)9056133

15. 2012-00250. Bacterial strains and consortia for bioleaching processes at lowtemperaturesandmethodsfortheiruse.DavorCotorras,PíaTobar,GidekelManuel

16. 61/634832.US20140235466-A1.NewPancreasMarker.GidekelManuel,EspinozaJaime,TeresaCabezón,MazzoliniGuillermo.(Publish)

17. 61/690392.Use CTBP1 siRNA for the treatment of Cancers. Gidekel Manuel, CarolinaBizama,OsvaldoPodhajcer.(Issue)

18. 14/120,777filingdate26/06/2014.61/957,617filingdate07/08/2013.Termiteandotherwood damaging insect control. Gidekel Manuel. Nationals Phases in USA (NotificationAllowance),Canada,Europe,NewZeeland,Australia,MexicoyIsrael.

19. 61/966,641. A novel virus and its manufacture. Osvaldo Podhajcer, Manuel Gidekel,EduardoCafferata,GuillermoMazzolini

20. US62/283,137. Antartina a Therapeutic Molecule. Manuel Gidekel, Julio Alvarez Builla,GuillermoMazzolini

21. 62/284,698. Filing date 10/05/2015. EcoPlus™ Increase Biomass Production. Gidekel Manuel

22. OfficialUSPTONotificationofNoticeofPublication:U.S.TrademarkSN86432454:EAGLEONEPLANTCARE

23. OfficialUSPTONotificationofNoticeofPublication:U.S.TrademarkSN86366436:EAGLEONESOILCARE

24. Official USPTO Notification of Notice of Publication: U.S. Serial Number:85556476ANTARTINA.12June2015

25. USPatentNumber9,491,950.Termiteandotherwooddamaging insectcontrol.GidekelManuel

26. 15/288,703 - Filing date October 7, 2016. Process for repairing damage to wood andrelated cellulosic products caused by Termites and other wood damaging insects.GidekelManuel.

27. 15/289,103filedOctober7,2016.Bio-nematicide.GidekelManuel28. 15/289,139 filedonOctober8, 2016. Insecticidal effect based on amodification of the

bacteriaofthegenusGluconacetobacter.GidekelManuel



ResearchJournalISIIF

1. Effectofwaterstressonplantgrowthandrootproteinpatternofthreecultivarsofrice(Oryzasativa)withdifferentdegreesoftolerance.Pérez-MolpheE.;GidekelM.;Segura-NietoM.;Herrera-EstrellaL.yOchoa-AlejoN.PhysiologiaPlantarum.96:284-290(1996).IF3,067

2. TheFirstIntronoftheGeneCodingfortheElongationFactor1ßofArabidopsisthalianaContainsanEnhancer-LikeElement.GidekelM., JiménezB.andHerrera-EstrellaL.Gene170:201-206.(1996)IF2,341

3. NucleotideSequenceofaTruncatedß1-3GlucanasefromtheGrapeCultivarCarmenere.RaúlHerrera,AnaGutiérrez,TamaraGaray,andManuelGidekel(AccessionNo.AJ245614).PlantPhysiol.121:1384(1998)IF7.054

4. EffectofNaClongrowthandproteinpatternsinthewakeofthreevarietiesofrice(OryzasativaL.)withdifferentdegreesoftolerance.Pérez-MolpheE.;GidekelM.yOchoa-Alejo.ScientiaeNaturae3:5-20(2000).

5. A Subset of Hybrid Eukaryotic Proteins is exported by the Type I Secretion System ofErwiniachrysanthemi. JoséLuisPalacios, IsabelZaror,PatricioMartínez,FranciscoUribe,Patricio Opazo, Teresa Socías, Manuel Gidekel and Alejandro Venegas. J. Bacteriology183:1346-1358.(2001)IF3,726

6. Deschampsia antarctica Desv. One source of genes during cold acclimatation.ManuelGidekel,LuisDestéfano,PatriciaGarcía,MarelyCuba,LorenaMújica,LidaFuentes,MirénAlberdi, León A. Bravo, Luis J. Corcuera, and Ana Gutiérrez. Extremophiles 7:459-469(2003)IF2,16

7. The Role of Photochemical Quenching and Antioxidants in Photoprotection ofDeschampsia antarctica Desv. Eduardo Pérez-Torres, Andrea García, Jorge Dinamarca,MirenAlberdi,AnaGutiérrez,ManuelGidekel,AlexanderG. Ivanov,NormanP.A.Hüner,LuisJ.CorcueraandLeónA.Bravo.FunctionalPlantBiology31:731-741.(2004)IF2,156

8. Micropropagation of Deschampsia antarctica Desv.-A frost-resistant Antarctic plant.Marely Cuba, Ana Gutiérrez-Moraga, Barbara Butendieck andManuel Gidekel. AntarcticScience.17:69-70.(2005)IF1,328

9. Light regulation of sucrose-phosphate synthase activity in the freezing-tolerant grassDeschampsia antarctica. Alejandra Zúñiga-Feest, Donald R. Ort, Ana Gutiérrez, ManuelGidekel,LeónA.Bravo,andLuisJ.Corcuera.PhotosynthesisResearch.83:75-86.(2005).IF2,41

10. Arabidopsis thaliana avoids freezingby supercooling.MarjorieReyes-Díaz,NancyUlloa,AlejandraZúñiga-Feest,AnaGutiérrez,ManuelGidekel,MirenAlberdi,LuisJ.CorcueraandLeónA.Bravo.J.ExperimentalBotany.57:3687-3696(2006).IF4,818



11. DifferentialGeneExpression inCallaLiliesPlants (Zantedeschia spp.).PamelaAlejandraLeal Rojas, Ana Gutiérrez Moraga, Adolfo Andrés Salvo Garrido and Manuel Gidekel.Agrociencia41:141-152(2007).IF0,294

12. Characterization of rhizospheric bacteria isolated from Deschampsia antarctica Desv.BARRIENTOSLeticia,GIDEKELManuelandGUTIÉRREZAna.WorldJournalofMicrobiologyandBiotechnology.24:2289-2296.2008.IF0,365

13. Immunotherapyforlivertumors:presentstatusandfutureprospects.PabloMatar,LauraAlaniz, Viviana Rozados, MarianaMalvicini, Catalina Atorrasgasti, Miguel Rizzo, Jorge B.Aquino, Manuel Gidekel, Marcelo Silva, Graciela Scharovsky and Guillermo Mazzolini.JournalofBiomedicalScience2009.6;16:30.IF1,96

14. Expression of a novel psychrophilic Cu/Zn superoxide dismutase from Deschampsiaantarctica. Sergio A Garcia Echauri, Manuel Gidekel, Ana Gutiérrez Moraga, Leandro GOrdóñez; Ana P Barba de la Rosa; AntonioDe León-Rodríguez. Process Biochemistry 44(2009)969–974.IF3,393

15. Molecular characterization of a cDNA encoding Cu/Zn superoxide dismutase fromDeschampsiaantarctica and its expression regulatedby coldandUV stresses. JaimeR.Sánchez-Venegas,JorgeDinamarcaAnaGutiérrezMoraga,ManuelGidekel.BMCResearchNotes2009,2:198.IF1,39

16. Cloning and constitutive expression of Deschampsia antarctica Cu/Zn superoxidedismutase in Pichia pastoris. Jaime R. Sánchez-Venegas, Alejandro Navarrete, JorgeDinamarca, León A. Bravo Ramírez, Ana Gutiérrez and Manuel Gidekel. BMC ResearchNotes2009,2:207.IF1,39

17. Isolation and characterization of pectic substances from murta (Ugni molinae Turcz)fruits.EdelioTaboada,PatricioFisher,RoryJara,ElisaZúñiga,ManuelGidekel,JuanCarlosCabrera, Eduardo Pereira, Ana Gutiérrez, Reynaldo Villalonga, Gustavo Cabrera. FoodChemistry,123(2010)669–678.IF3,458

18. Reversal of gastrointestinal carcinoma-induced immunosuppression and induction ofantitumoural immunitybyacombinationofcyclophosphamideandgenetransferof IL-12, Mariana Malvicini, Mariana Ingolotti, Flavia Piccioni, Mariana Garcia, Juan Bayo,Catalina Atorrasagasti, Laura Alaniz, Jaime Espinoza, Manuel Gidekel, Graciela O.Scharovsky,PabloMatarandGuillermoMazzolini.MolecularOncology.2011;5(3):242-55.IF4,250

19. Genistein selectively inhibits estrogen-induced cell proliferation and some otherresponsestohormonestimulationintheprepubertalratuterus.TCHERNITCHINAndres,GAETE Leonardo, GIDEKELManuel, CABRERA Gustavo. JMed Food 14 (12) 2011, 1597–1603.IF1,462

20. IsolationandphylogeneticclassificationofcultivablepsychrophilicprokaryotesfromtheCollins glacier in theAntarctica.SergioA.García-Echauri,ManuelGidekelAnaGutiérrez



Moraga,LeticiaSantos,andAntonioDeLeón-Rodríguez.FoliaMicrobiologica,56(3):209-142011.IF0,977

21. Double mutation in photosystem II reaction centers and elevated CO2 grantthermotolerance to mesophilic cyanobacterium. DINAMARCA Jorge, SHLYK-KERNEROksana, KAFTAN David, GIDEKEL Manuel, GUTIERREZ Ana & SCHERZ Avigdor. Plos One20116:12,1-13IF4,411

22. Atumor-stromatargetedoncolyticadenovirusreplicatedinhumanovarycancersamplesand inhibitedgrowthofdisseminatedsolidtumors inmice.M.VeronicaLopez,AngelA.Rivera, Diego L. Viale, Lorena Benedetti, Nicasio Cuneo, Kristopher J.Kimball, MinghuiWang, Joanne T. Douglas, Zeng B. Zhu, Alicia I. Bravo,Manuel Gidekel,RonaldD.Alvarez,DavidT.CurielandOsvaldoL.Podhajcer.MolecularTherapy2012,20:2222-2233.IF.6,873

23. Chemoimmunotherapy for advanced gastrointestinal carcinomas: a successfulcombination of gene therapy and cyclophosphamide.MarianaMalvicini, FlaviaPiccioni,Juan Bayo, Esteban Fiore, Catalina Atorrasagasti, Laura Alaniz, Mariana García, Jorge BAquino,Manuel Gidekel, PabloMatar and GuillermoMazzolini.OncoImmunology 2012;1:1626-1628.IF.6,283

24. CharacterizationofAntarcticPGPRbacterialstrainanditsinteractionwithDeschampsiaantarctica Desv. Graciela Berríos, Gustavo Cabrera, Manuel Gidekel and Ana Gutiérrez.PolarBiology.DOI10.1007/s00300-012-1264-6.IF2,006

25. Differentially expressed genes induced by cold and UV-B in Deschampsia antarctica.Jorge Dinamarca, Alejandra Sandoval,Manuel Gidekel and Ana Gutiérrez. Polar Biology.DOI10.1007/s00300-012-1271-7.IF2,006

26. Daidzein–Estrogen Interaction in theRatUterusand itsEffectonHumanBreastCancerCells Growth. Gaete L, Tchernitchin AN, Bustamante R, Villena J, Lemus I, Gidekel M,CabreraG.AstorgaP.JMedFood15(12)2012,1081–1090.IF1,462

27. Living Architecture. Micro performances of bio fabrication. Sergio Araya, EkaterinaZolotovsky,ManuelGidekel.ECAADE2013,VOL2:PHYSICALDIGITALITY437-448

28. The low-abundance transcriptome reveals novel biomarkers, specific intracellularpathwaysandtargetablegenesassociatedwithadvancedgastriccancer.CarolinaBizama,Felipe Benavente, Edgardo Salvatierra, Ana Gutiérrez, Jaime A. Espinoza, Elmer A.Fernández, Iván Roa, Guillermo Mazzolini, Eduardo A. Sagredo, Manuel Gidekel* andOsvaldoL.Podhajcer*.InternationalJournalofCancerDOI:10.1002/ijc.28405.IF6,198

29. Effects of growth regulators and scanning electron microscopic study in the somaticembryogenesis of Antarctic hair grass (Deschampsia antarctica Desv)." JenniferOsorio,Claudia Calderón, Ana Gutiérrez Moraga and Manuel Gidekel. Polar Biology. Volume37,Issue2,pp217-225.2014.IF2,006



30. ExpressionofaDeschampsiaantarcticaDesv.PolypeptidewithLipaseActivityinaPichiapastoris Vector. Claudia Rabert, Ana Gutiérrez-Moraga, Alejandro Navarrete, DaríoNavarrete-Campos, León A. Bravo, andManuel Gidekel. Int. J.Mol. Sci. 2014, 15, 2359-2367.IF2,464

31. SPARC (Secreted Protein Acidic and Rich in Cysteine) knockdown protects mice fromacute liver injury by reducing vascular endothelial cell damage. Estanislao Peixoto,CatalinaAtorrasagasti,JorgeB.Aquino,RodrigoMilitello,JuanBayo,EstebanFiore,FlaviaPiccioni, Edgardo Salvatierra, Laura Alaniz,Mariana G. García Ramón Bataller, FernandoCorrales, Manuel Gidekel, Osvaldo Podhajcer, María Isabel Colombo and GuillermoMazzolini.GeneTherapy11/2014;2014:1-11.,IF4,321

32. AnovelCDC25Bpromoterbasedoncolyticadenovirusinhibitedgrowthofadisseminatedhuman pancreatic cancer model implanted orthotopically. Helga L. Weber, ManuelGidekel,David T. Curiel, Eduardo G. Cafferata and Osvaldo L. Podhajcer. Clinical CancerResearch,2015.doi:10.1158/1078-0432.CCR-14-2316.IF8,139

33. IL-8, GRO andMCP-1 produced by hepatocellular carcinoma determine the migratorycapacityofhumanmesenchymal stromal cellswithoutaffecting tumoraggressiveness.,Bayo J, Real A, Fiore E, Bolontrade M, Andriani O, Bizama C, Fresno C, Podhajcer O,Fernandez E, Gidekel M, Mazzolini G., Garcia MG. Oncotarget, 2016. DOI:10.18632/oncotarget.10288. IF6,368

Inpreparation

Antarcticabacteriummodulatesrootarchitectureandimprovesproductivity.AmelieGauidin+,Kaisa Kajala+, AnaGutierrez+, Gino Corsini, AddaMora, David Coil, Guillaume Jospin, SiobhanBrady,MichaelParrella,JonathanEisen*andManuelGidekel*

Antartina, a synthetic secondary metabolic from Deschampsia antartica Desv., inhibitscolorectalcarcinomagrowthandlivermetastasisthroughthe inductionofaspecific immuneresponse.MalvicciMariana,AnaGutierrez,LorenaSalazar,LeonorNozal, Antonio Salgado,Marcelo Rodriguez, Jose Luis Novella, Julio Alvarez Builla, Manuel Gidekel* and GuillermoMazzolini*.

Conferences

Morethan100nationals&internationalspresentations

2012.Speaker.Misti.MITSeedFunds.(Boston,14-21July)

2012.Speaker.AUTM.EmoryUniversity,OfficeofTechnologyTransfer(Atlanta,16Juneto6July)



2012.Speaker.StrategiesforinnovationandentrepreneurshipinChile.STRATEGICMANAGEMENTOFINTELLECTUALPROPERTY.WIPOAcademy.March14a16.SantiagodeChile.

2011.Speaker.Workshop.InternationalSymposium:Bio-informaticsfortheDevelopmentofTechnology-BasedFirms.MinisteriodeCienciayTecnología.BuenosAires,Argentina

2011.AcuerdodeColaboración.VentureLabandAlthoUniversityofHelsinki,Finland

2011.AcuerdodeColaboración.VentureLabyTecnológicodeMonterrey,Guadalajara,México

2011.AcuerdodeColaboración.VentureLabandKarolinskaCancerCenter,Stockholm,Sweden

2011.Speaker.OpeningofthePostgraduateSchool.TecnológicodeMonterrey,CampusGuadalajara.México.

2010.Speaker.Colciencias.ValuationofR&Dwithmarketvision.BestPracticesinDesignandManagementofFinancialInstruments,tofosterinnovation.Bogotá,20y21October2010.

2010.Speaker.CollaborationinScienceandTechnology:AustriaandChile,AssociateinScienceandInnovation.ResearchandInnovation:Knowledgeasthekeytosuccessinthemarket.DRICONICYTyEmbassydeAustriaenChile.

Partnerships

VitroGenS.A.Since2000.Director.President

UxmalS.A.Since2006.CEO.

ConsorciodeTecnologíaeInnovaciónparalaSalud-CTISaludS.A.Since2006Founder&COO.Since2016.President

BioFixSpA.SinceJuly2012.Partner&Director

CreativeBioScienceSpA,SinceDecember2013.Partner&Director

Inversion,CienciayTecnologiaSpA,SinceMay2014.President

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