CURRICULUM VITAE Daniel Frederick Klessig Boyce Thompson Institute for Plant Research –Professor, past President and CEO Cornell University – Adjunct Professor in Department of Plant Pathology and Plant-Microbe Biology Tower Road Ithaca, NY 14853 (607) 254-4560 Education: B.S. 1971 Biochemistry (Summa cum laude) University of Wisconsin Madison, Wisconsin Honours B.Sc. 1973 Molecular Biology (1st Class) University of Edinburgh Edinburgh, Scotland, UK Ph.D. 1978 Biochemistry and Molecular Biology Harvard University Cambridge, Massachusetts Research Training: 1970-1971 Undergraduate work with Professor J. E. Dahlberg. Senior Thesis entitled, "Development of improved methods in

RNA sequencing". University of Wisconsin, Department of Physiological Chemistry.

1971-1973 Student research projects in the MRC Molecular Genetic Unit at Edinburgh University.

1974-1977 Graduate work with Drs. J. D. Watson and R. Gesteland. Ph.D. Thesis entitled, "Control of gene expression in human adenovirus serotype 2." Cold Spring Harbor (CSH) Laboratory.

1978 Postdoctoral work with Dr. J. Sambrook, CSH Lab. Professional Positions Held: Staff Scientist, 1979-1980, Cold Spring Harbor Laboratory Assistant Professor, 1980-1983, Department of Cellular, Viral and Molecular

Biology, University of Utah Associate Professor, 1983-1985, Department of Cellular, Viral and Molecular

Biology, University of Utah Professor, 1985-1991, Waksman Institute, Rutgers University Professor II, 1991-2000, Waksman Institute, Rutgers University Associate Director, 1985-2000, Waksman Institute, Rutgers University President & CEO, 2000-2004, Boyce Thompson Institute for Plant Research Adjunct Professor, 2000-present, Department of Plant Pathology and Plant-

Microbe Biology, Cornell University Professor, 2004-present, Boyce Thompson Institute for Plant Research Awards/Honors: Phi Kappa Phi, Alpha Zeta, Phi Lambda Upsilon and Gamma Sigma Delta

Honorary Fraternities Danforth Leadership Scholarship, 1968 Marshall Scholar to the United Kingdom, 1971-1973 Searle Scholar, 1982-1985 McKnight Scholar, 1983-1986

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Faculty Research Award from American Cancer Society, 1984-1988 Japan Society for Promotion of Science Fellow, 1997 Fellow of the American Academy of Microbiology, 2001 Noel T. Keen Award for Research Excellence in Molecular Plant

Pathology, 2011 Fellow of the American Association for Advancement of Science, 2012

Member: American Association for the Advancement of Science American Society of Plant Biologists (Physiologists) International Society for Plant Molecular Biology International Society for Molecular Plant-Microbe Interaction American Phytopathological Society American Society for Microbiology Editorial Boards: Plant Signaling and Behavior, 2005- 2012 Molecular Plant Pathology, 2000- 2005 Virology, 1985-1998 Plant Physiology, 1996-1997 Journal of Virology, 1989-1995 Molecular and Cellular Biology, 1987-1994 Virus Research, 1983-1989 Journal of Molecular and Applied Genetics, 1981-1984 Teaching: 1973-1974, Head Teaching Fellow for a course in introductory biology, Harvard

University 1981, Course on mRNA metabolism in eukaryotes for graduate students – Univ. of

Utah 1982-1985, Course on gene regulation in prokaryotes and eukaryotes and an

introduction to animal viruses for medical students – Univ. of Utah 1983, Plant molecular biology mini-course, organized together with Raymond

Gesteland – Univ. of Utah 1991 and 1992, Organizer of Cold Spring Harbor Lab course on Molecular and

Developmental Biology of Plants 1986-1994, Director, advanced recombinant DNA techniques course for graduate

students – Rutgers University 1993-2000, Biochemistry and Molecular Biology course for undergraduate and

graduate students – Rutgers University 2008, Current Papers in Plant Biology 2004-present, Problems in Plant Cell & Mol. Biol.

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Grants: (Current grants are highlighted) Institute-wide grants obtained for BTI: “Molecular and Chemical Ecology Program” 1/1/02-12/31/06 $3,994,000* Atlantic Philanthropies, Inc. *shared equally with Cornell University and co-authored with T. Eisner and J.

Meinwald “Plants and Human Health” 1/1/04-12/31/07 $1,000,000 Triad Foundation 4/1/03-3/31//04 $250,000 Triad Foundation 4/1/02-3/31/03 $250,000 Park Foundation Plant Research: “Characterization & utilization of nematode ascaroside (NA)-induced plant immunity” 4/1/2017 – 3/31/20 $474,072 USDA “The Arabidopsis salicylic acid signaling network: A paradigm for phytohormone

signaling” – Creativity-based Supplement 6/1/14 – 5/30/17 $200,000 “Reducing losses to potato and tomato late blight by monitoring pathogen populations,

improved resistant plants, education and, extension” 3/1/2011 – 2/28/2016 $9,000,000 USDA (one of 22 co-IPs) “The Arabidopsis salicylic acid signaling network: A paradigm for phytohormone

signaling” 6/1/09 - 5/31/14 $2,279,000 NSF 2010 (w/several co-PIs) “NO synthase and NO-mediated signaling in plant defense” 7/1/03 - 6/30/08 $1,083,000 NIH "Characterization of salicylic acid binding proteins in plant defense responses" 8/1/05 - 7/31/09 $668,000 NSF 8/15/03 - 8/14/05 $288,000 NSF 9/1/01 - 8/31/02 $100,000 NSF 9/1/99 - 8/31/01 $220,000 NSF "Involvement of salicylic acid inhibition of catalase and ascorbate peroxidase in plant

defense responses" 9/1/96 - 8/31/99 $300,000 NSF "Salicylic acid binding proteins" 9/1/93 - 8/31/95 $133,000 CIBA-Geigy 9/1/90 - 8/31/93 $158,000 CIBA-Geigy "Characterization of the salicylic acid binding protein" 9/15/92 - 9/14/94 $105,000 USDA "Characterization of the salicylic acid signal transduction pathway in plant defense

responses" 9/1/01 - 8/31/05 $600,000 NSF 10/1/97 - 9/30/01 $600,000 NSF 8/1/93 - 7/31/97 $535,000 NSF "Pathogenesis-related proteins of Nicotiana" 8/1/90 - 7/31/93 $412,000 NSF 7/1/87 - 6/30/90 $300,000 NSF 10/1/85 - 9/30/87 $110,000 USDA "Characterization of the Arabidopsis HRT gene, which confers resistance to turnip

crinkle virus" 5/1/07 – 3/31/11 $680,000 NSF (with Co-PI Pradeep

Kachroo) 7/1/03 - 6/30/06 $300,000 USDA 9/1/99 - 8/3/02 $225,000 USDA

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9/1/97 - 8/31/99 $120,000 USDA "Tobacco SIPK-encoded MAP kinase associated with defense responses to pathogens" 9/1/98 - 8/31/01 $190,000 USDA "Control of ribulose 1,5-bisphosphate carboxylase gene expression in

amaranth/posttranscriptional regulation of chloroplast gene expression" 8/1/89 - 7/31/91 $150,000 NSF 3/1/86 - 8/31/89 $208,000 NSF 11/1/82 - 2/28/86 $189,000 NSF "Photoinduction and coordinate expression of ribulose 1,5-bisphosphate carboxylase

gene in grain amaranth" 3/1/83 - 2/28/86 $105,000 McKnight Scholarship Animal DNA Tumor Virus Research: "The multi-functional adenovirus DNA binding protein" 9/1/90 - 8/31/95 $1,507,000 NIH 9/1/85 - 8/31/90 $1,003,000 NIH 7/1/80 - 8/31/85 $636,000 NIH "Abortive infection of monkey cells by human adenoviruses" 7/1/88 - 6/30/90 $160,000 ACS 1/1/84 - 6/30/87 $282,000 NIH 1/1/83 - 12/31/83 $82,000 ACS 1/1/81 - 12/31/82 $150,000 ACS (American Cancer Society) "Regulation of gene expression in eukaryotes" 1/1/84 - 12/31/88 $155,000 ACS Faculty Research Award "Control of gene expression in eukaryotes" 10/1/82 - 2/28/86 $155,000 Searle Scholarship Invited Lectures at Scientific Meetings:

Keynote at Drug Discovery & Therapies World Congress 2016 and Global Biotechnology Congress, Boston, MA 2016 Keynote at Mid Atlantic Plant Molecular Biology Society meeting, College Park MD 2015 Keynote on SA and its plant and human targets at PR-IR Workshop, Aachen, Germany 2015 Second lecture on induction of plant immunity by nematode ascarosides at PR-IR Workshop, Aachen, Germany 2015 Keynote at Chilean Plant Molecular Biology Meeting, Valdivia, Chile 2015

XVI Int’l Symposium on Molecular Plant- Microbe Interaction Rhodes, Greece 2014 Keynote Lecture Korean Society of Plant Pathology Annual Meeting, Suncheon, Korea 2013 R. R. Nelson Memorial Lecture in Plant Pathology, Penn. State University, State College, PA 2012

3rd Sophia Antipolis Workshop on Compatibility Mechanisms in Plant-Microbe Interactions Sophia, France 2011 PR-Proteins and Induced Resistance Against Pathogens and Insects 2011 – Neuchatel,

Switzerland 2011 Conference on “The Contributions of Plant Biotechnology in Confronting Climate

Change” – Tunis, Tunisia 2010 Int’l Conference on Plant Vascular Biology 2010 – Columbus, OH Mol. & Envir. Plant Sciences Symposium – Texas A&M 2010

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Keynote: IV Annual Chilean Plant Biology Meeting, LaSerna, Chile – 2009 XII Buenos Aires Plant Biology Lectures – Argentina 2009 Pathogenesis-related Proteins and Induced Resistance Workshop – Doorn,

Netherlands 2007 XIII Int’l Congress on Molecular Plant-Microbe Interactions, Sorrento, Italy 2007 4th Tri-national Arabidopsis Meeting, Vienna, Austria 2007 Roy C. Anderson Memorial Lecture in Parasitology, University of Guelph, Guelph,

Canada 2007 ASPB-Southern section symposium – Daytona, FL 2006 (Keynote Speaker) Iowa State University Plant Receptor Signaling Symposium – Ames, IA 2006 American Phytopathology Society / Canadian Phytopathology Society Meeting –

Quebec City, Canada 2006 Symposium on “Non-specific and specific innate and acquired plant resistance” –

Budapest, Hungary 2006 Canadian Society of Plant Physiologists – Eastern region meeting – Hamilton,

Canada 2006 (Keynote Speaker) XII Int’l Congress on Molecular Plant-Microbe Interactions – Cancun, Mexico

2005 American Society for Virology 24th Annual Meeting;Plant Virology Club Satellite

Symposium – State College, PA 2005 Plant Molecular Biology Gordon Research Conference – Plymouth, NH 2004 Juan March Foundation Workshop on Disease Resistance and Related Signaling

Mechanisms in Plants – Madrid, Spain, 2004 International Joint Workshop on PR Proteins and Induced Resistance – Denmark,

2004 Colloquium on Entrepreneurship and Biotechnology: The Coming Revolution”,

Elkhorn, Montana, 2004 Annual Meeting of American Society of Plant Biologists – Orlando, FL, 2004,

Dhirendra Kumar substituted for Dan due to health Annual Meeting of American Phytopathology Society – Anaheim, CA, 2004,

Dhirendra Kumar substituted for Dan due to health NATO Advanced Research Workshop on Cell Biology and Instrumentation: UV

Radiation, Nitric Oxide and Cell Death – Yalta, Ukraine, 2004 David Wendehenne substituted for Dan due to health

Iowa State University Symposium – Ames, IA, 2004, Meena Chandok substituted for Dan due to health

15th International Conference on Arabidopsis Research – Berlin, Germany, 2004, Declined due to health

International Conference on Plant Growth Substances – Canberra, Australia, 2004, Declined due to health

3rd International Conference on Biology, Chemistry, and Therapeutic Applications of Nitric Oxide – Nara, Japan, 2004, Declined due to health

8th International Congress on Plant Pathology – Keynote Address – Christchurch, New Zealand, 2003

7th International Congress of Plant Molecular Biology – Barcelona, Spain, 2003 11th International Congress on Molecular Plant-Microbe Interactions – Plenary

Lecture – St. Petersburg, Russia, 2003 Symposium honoring J. D. Watson and the 50th Anniversary of the discovery of the

double-helical structure of DNA – Cold Spring Harbor, NY, 2003 MidAtlantic Plant Molecular Biology Conference – Keynote Address, Beltsville,

MD, 2002 Annual Meeting of Canadian Society of Plant Physiologists, Calgary, Canada, 2002

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European Flying Fellowship in Plant Molecular Biology, Cologne, Germany; Ghent, Belgium; Wageningen, Netherlands; and Gif-sur-Yvette, France, 2002

Annual Meeting of American Phytopathological Society, 2001 10th Congress of the International Society of Molecular Plant-Microbe Interactions,

2001 Annual Meeting of American Society of Plant Biologists, 2001 27th Meeting of FEBS and Pan-American Association of Biochemistry and

Molecular Biology, Lisbon, Portugal, 2001 17th International Conference on Plant Growth Substances, Brno, Czech Republic,

2001 6th International Workshop on Pathogenesis-Related Proteins in Plants, Spa,

Belgium, 2001 Commemorative Symposium of the Center for Plant Molecular Genetics and

Breeding Research, Seoul National University, Korea, 2000 First International Symposium on Induced Resistance to Plant Diseases, Corfu,

Greece, 2000 International Symposium on Plant Signaling 2000, Penn State, 2000 Gatsby Fellow Lecture Series, Sainsbury Laboratory, John Innes Centre, Norwich,

UK, 2000 Keystone Symposium on Signals and Signal Perception in Biotic Interactions in

Plants, 2000 9th International Congress of Molecular Plant-Microbe Interactions, Amsterdam,

Netherlands, 1999 Annual Meeting of the American Society of Virology, 1999 International Symposium on Plant Signal Transduction, New Delhi, India, 1999 U.S. National Academy of Sciences Colloquium on Virulence and Defense in

Host-Pathogen Interactions: Common Features between Plants and Animals, 1999

Cell Death in Plants: Functions and Mechanisms, Banbury Center Meeting, Cold Spring Harbor Laboratories, 1999

American Society of Pharmacognosy, Association Française pour l'Enseignement et la Recherche en Pharmacognosie, Gesellschaft für Arzneipflanzenforschung and the Phytochemical Society of Europe sponsored Symposium on 2000 Years of Natural Products Research - Past, Present and Future. Amsterdam, The Netherlands, 1999

University of Missouri Spring Symposium on Plant Hormones: Signaling and Gene Expression, 1999

Gordon Research Conference on Antimicrobial Peptides, Barga, Italy, 1999 Juan March Foundation sponsored Meeting on Novel Approaches to Study Plant

Growth Factors, Madrid, Spain, 1998 International Symposium of the Polyphenols Group, Lille, France, 1998 7th International Congress of Plant Pathology, Edinburgh, UK, 1998 International Symposium on Recent Advances and Future Perspectives in Life

Science, Gyeongsang, South Korea, 1998 5th International Workshop on Pathogenesis-Related Proteins in Plants, Aussois,

France, 1998 5th International Congress of Plant Molecular Biology, Singapore, Malaysia, 1997 Congress on In Vitro Biology, Washington, DC, 1997 Joint Meeting of Phytochemical Society of Europe and Phytochemical Society of

North America, Noordwijkerhout, Netherlands, 1997 Keystone Symposium on Metabolic Engineering in Transgenic Plants, 1997

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Spring Symposium on Information Processing Systems in Plants, University of California, Davis, 1997

8th International Symposium on Molecular Plant-Microbe Interactions, 1996 15th International Conference on Plant Growth Substances, 1995 4th International Workshop on Pathogenesis-Related Proteins in Plants, Kloster

Irsee, Germany, 1995 Workshop on Molecular Biology of Disease Resistance Genes in Plants, Banbury

Center, Cold Spring Harbor Laboratories, 1995 COE Symposium on Defense Responses in Plants, Tsukuba, Japan, 1995 Keystone Symposium on Signal Transduction in Plants, 1995 U. S. National Acad. of Science Colloquium on Self-Defense by Plants, 1994 German Botanical Society Biannual Meeting, Bayreuth, Germany, 1994 Annual Meeting of Society of Industrial Microbiologist, 1994 Annual National Meeting of ASPP, 1994 7th International Symposium of Molecular Plant-Microbe Interaction, Edinburgh,

UK, 1994 4th International Congress on Plant Molecular Biology, Amsterdam, Netherlands,

1994 Clusius Symposium, Leiden, Netherlands, 1994 Annual Meeting of the Washington Area Section of the ASPP, 1994 Merck Symposium on Antifungal Discovery for Crop Protection, 1994 American Phytopathology Society Symposium, 1993 Gordon Research Conference on Plant Molecular Biology, 1993 British Biochemical Society Annual Symposium, Leeds, UK, 1993 Annual European Federation of Plant Pathologists, Strasbourg, France, 1992 3rd International Workshop on Pathogenesis-Related Proteins in Plants, Arolla,

Switzerland, 1992 Annual Meeting of Northeast Section of the ASPP, 1992 Gordon Research Conference on Plant Molecular Biology, 1991 Annual Meeting of American Phytopathological Society, 1990 Gordon Research Conference on Plant Molecular Biology, 1990 Conference on Approaches to Genetic Manipulations in Biology and Medicine,

Vienna, Austria, 1990 2nd International Workshop on Pathogenesis-Related Proteins in Plants, Valencia,

Spain, 1989 52nd Annual Meeting of the Northeastern Section of the American Society of Plant

Physiologists (ASPP), 1988 Second Annual ASM Conference on Biotechnology, 1987 FASEB Summer Research Conference on Plant Gene Expression, 1987 International Workshop on RUBISCO 87 - Genes, Proteins and the Regulation of

Activity, 1987 Gordon Research Conference on Plant Molecular Biology, 1987 Gordon Research Conference on Plant Molecular Biology, 1986 Viruses as Models for Eukaryotic Gene Expression: ICN-UCI Symposium, 1986 Translational Regulation Meeting at CSH Lab, 1985 DNA Tumor Viruses: Control of Gene Expression and Replication Meeting at CSH

Lab, 1985 Chairperson of Adenovirus Transcription Session - Annual SV40, Polysoma,

Adenovirus Meeting at CSH Lab, 1982 Symposium on RNA Splicing - ASM Annual Meeting, 1978

Peer Review

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Committees: Member of Advisory Panel for Eukaryotic Genetics of NSF, 1988-1996 Member of Advisory Panel for Science and Technology Center for NSF, 1989 Basic Research Advisory Group for the New Jersey Commission on Cancer

Research, 1987 - 1995 Ad hoc member of Virology Study Section of NIH, 1983 Peer Review Member, Boyce Thompson Institute, 1998 Review Committee for Life Sciences at Brookhaven National Laboratory, 2000 Several site visit teams University of Utah Committees: Biochemistry Chairperson Search Committee, 1982-1983 Steering Committee for the B.S. - M.S. Program in Molecular Biology and

Genetic Engineering, 1982-1983 Departmental Seminar Chairperson, 1980-1983 Genetics Postdoctoral Fellowship Committee, 1981-1985 Rutgers University Committees: Faculty Senate, 1990-1993 Executive Committee for the Graduate School, 1992-1994 University Appointments and Promotion Committee, 1996-1998 Ad hoc Committee for Consolidation of Graduate Programs in the Biological

Sciences, 1993-1994 Search Committee for Dean of Faculty of Arts and Sciences, 1990 Government Relationship Committee, 1988-1989 University Advisory Committee for the J & J Discovery Research Fund, 1988-1990 Executive Committee of Biochemistry Graduate Program, 1990-1993 Executive Committee of Biochemistry and Molecular Biology Graduate Program,

1987-1990 Recruitment Committee of Microbiology and Molecular Genetics Graduate

Program,1989-1992 Faculty Search Committee for the Center for Advanced Biotechnology and

Medicine, 1986-1990 Molecular Biology and Biochemistry Chairperson Search Committee, 1986-1987 Molecular Biology and Biochemistry Faculty Search Committee, 1990-1992 Molecular Biology and Biochemistry Planning and Policy Committee, 1990-2000 Chair of Appointments and Promotion Committee for Waksman Institute, 1994-2000 Appointments and Promotion Committee for Waksman Institute 1986-1988 1991-1994 Chairman of Faculty Search Committee for Waksman Institute 1986-1987 1989-1990 1992-1994 Chair, Busch Fund and Fellowship Committee for Waksman Institute, 1988-1991 Busch Funds Committee for Waksman Institute, 1986-1988 Lectures and Seminars Committee for Waksman Institute, 1986-1988

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Cornell University Committees: Provost’s Life Science Advisory Counsel, 2000-2003 Governing Board of Center for the Environment, 2000-2002 Environmental Sustainability Committee, 2001 Lab Personnel: Postdoctoral Fellows:

Kevin Anderson 1980-1984 Robert Boone 1981-1983 Basil Nikolau 1983-1985 Jeffrey Johnston 1984-1985 Karl Voelkerding 1984-1986 Guo-shun He 1986-1987 James Berry 1982-1988 Fumio Tashiro 1986-1988 Nathalie Morin 1986-1989 Claude Delsert 1986-1989 John Carr 1984-1989 Mary Metzler 1988-1989 David Breiding 1985-1990 Ralph Dewey 1987-1990 John Cutt 1986-1991 Jacek Hennig 1990-1992 John Martyn 1992-1993 Paloma Sanchez-Casas 1992-1993 Joseph Ricigliano 1989-1993 Kristin Wobbe 1991-1994 John Tonkyn 1992-1995 Andrew Bendall 1993-1995 Uwe Conrath 1993-1995 Hideki Takahashi 1994-1995 Zhixiang Chen* 1990-1995 Marc Anderson 1995-1996 Ailan Guo 1993-1997 Sudam Pathirana 1994-1997 Yinong Yang 1994-1997 Ismael Rodrigo 1996-1998 David Wendehenne 1996-1998 Jyoti Shah 1992-1998 Jörg Durner* 1994-1998

Shuqun Zhang 1995-1998 He Du 1995-1998 Jihad Attieh 1998 Michael Cooley* 1996-1999 Robert Noad 1998-1999 Gaza Salih 1998-1999 Susan Rasmussen 1999-2000 Youssef Trifa 1999-2000 Yanhong Liu 1997-2001 Roy Navarre 1997-2001 Shashi Sharma 1998-2001 David Slaymaker 1999-2001 Pradeep Kachroo* 1997-2002 Yumiko Shirano 1998-2002 Hui-Ju Wu 1998-2002 Frank Menke 1999-2002 Jeong Mee Park 2000-2002 Joseph Kuhl 2000-2002 Keiko Yoshioka* 1998-2003 Wolfgang Möder 2000-2003 Meena Chandok* 2000-2004 Dhirendra Kumar* 1998-2005 Jitae Kim 2003-2005 Fasong Zhou* 2001-2005 Corina Vlot 2003-2006 Miaoying Tian 2005-2006 Yongzeng Wang 2004-2007 Evans Kaimoyo 2005-2007 Hong-Gu Kang* 2000-2011 Magali Moreau* 2005-2013 Patricia Manosalva* 2007-2014 Po-Pu Liu* 2007-2012 Caroline von Dahl 2007-2011

Gyu In Lee 2003-2008 Miaoying Tian* 2009-2013 Sang Wook Park 2004-2008 Hyong-Woo Choi* 2011-present Katarzyna Lorenc-Kukula 2011-2012

Murli Manohar* 2012-present Lei Wang 2017

* promoted to Research Associate or Senior Research Associate

Graduate Students:

Steve Rice 1980-1985 Lauren Silverman 1984-1989 David Dixon 1984-1991

Vaughn Cleghon 1986-1991 Pat Eagle 1988-1991 Douglas Brough 1986-1992

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Jocelyn Malamy 1988-1993 Younggyu Kim 1992-1995 D'Maris Dempsey 1987-1996

Herman Silva 1993-1998 Jun Ma Zhou 1997-2001 Daniel Clark 1999-2003

Publications: 1. Klessig, D.F. and Anderson, C.W. (1975) Block to multiplication of adenovirus serotype 2 in

monkey cell. J. Virol. 16: 1650-1668. 2. Klessig, D.F. (1977) Isolation of a variant of human adenovirus serotype 2 that multiplies

efficiently on monkey cells. J. Virol. 21: 1243-1246. 3. Klessig, D.F. (1977) Two adenovirus mRNAs have a common 5' terminal leader sequence

encoded at least 10 kb upstream from their main coding regions. Cell 12: 9-21. 4. Klessig, D.F. and Hassell, J.A. (1978) Characterization of a variant of human adenovirus type 2

which multiplies efficiently in simian cells. J. Virol. 28: 945-956. 5. Gelinas, R.E., Chow, L.T., Roberts, R.J., Broker, T.R. and Klessig, D.F. (1978) The structure of

late adenovirus type 2 messenger RNAs. Brookhaven Symp. 29: 345-347. 6. Broker, T.R., Chow, L.T., Dunn, A.R., Gelinas, R.E., Hassell, J.A., Klessig, D.F., Lewis, J.B.,

Roberts, R.J. and Zain, S.D. (1978) Adenovirus 2 messengers - an example of baroque molecular architecture. Cold Spring Harbor Symp. Quant. Biol. 42: 531-553.

7. Klessig, D.F. and Grodzicker, T. (1979) Mutants that allow human Ad2 and Ad5 to express late genes in monkey cells map in the viral gene encoding the 72K DNA binding protein. Cell 17: 957-966.

8. Klessig, D.F. and Chow, L.T. (1980) Incomplete splicing and deficient accumulation of the fiber messenger RNA in monkey cells infected by human adenovirus type 2. J. Mol. Biol. 139: 221-242.

9. Alestrom, P., Akusjarvi, G., Perricaudet, M., Mathews, M.B., Klessig, D.F. and Pettersson, U. (1980) The gene for polypeptide IX of adenovirus type 2 and its unspliced messenger RNA. Cell 19: 671-681.

10. Grodzicker, T. and Klessig, D.F. (1980) Expression of unselected adenovirus genes in human cells co-transformed with HSV-1 tk gene and adenovirus 2 DNA. Cell 21: 453-463.

11. Klessig, D.F., Quinlan, M.P. and Grodzicker, T. (1982) Proteins containing only half the coding information of early region 1b of adenovirus are functional in human cells transformed with HSV-1 tk gene and adenovirus DNA. J. Virol. 41: 423-434.

12. Anderson, K.P. and Klessig, D.F. (1982) Synthesis of human adenovirus early RNA species is similar in productive and abortive infections of monkey and human cells. J. Virol. 42: 748-754.

13. Klessig, D.F. and Quinlan, M.P. (1982) Genetic evidence for separate functional domains on the human adenovirus specified 72 kd, DNA binding protein. J. Mol. Appl. Genet. 1: 263-272.

14. Klessig, D.F. and Quinlan, M.P. (1982) Normal translation of human adenovirus mRNA in cell-free systems prepared from abortively as well as productively infected monkey cells. J. Virol. 44: 426-430.

15. Anderson, K.P. and Klessig, D.F. (1983) Posttranscriptional block to synthesis of a human adenovirus capsid protein in abortively infected monkey cells. J. Mol. Appl. Genet. 2: 31-44.

16. Anderson, C.W., Hardy, M.M., Dunn, J.J. and Klessig, D.F. (1983) Independent, spontaneous mutants of Ad2+ND3 that grow efficiently in monkey cells possess identical mutations in the adenovirus 2 DNA binding protein gene. J. Virol. 48: 31-39.

17. Klessig, D.F. and Berry, J.O. (1983) Improved filter hybridization method for detection of single copy sequences in large eukaryotic genomes. Plant Mol. Biol. Reporter 1: 12-18.

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18. Rice, S.A. and Klessig, D.F. (1984) The function(s) provided by the adenovirus specified, DNA binding protein required for viral late gene expression is independent of the protein's role in viral DNA replication. J. Virol. 49: 35-49.

19. Klessig, D.F., Grodzicker, T. and Cleghon, V. (1984) Construction of human cell lines which contain and express the adenovirus DNA binding protein gene by co-transformation with HSV-1 tk gene. Virus Res. 1: 169-188.

20. Anderson, K.P. and Klessig, D.F. (1984) Altered mRNA splicing in monkey cells abortively infected with human adenovirus may be responsible for inefficient synthesis of the virion fiber polypeptide. Proc. Natl. Acad. Sci. USA 81: 4023-4027.

21. Klessig, D.F., Brough, D.E. and Cleghon, V. (1984) Introduction, stable integration, and controlled expression of a chimeric adenovirus gene whose product is toxic to the recipient human cell. Mol. Cell. Biol. 4: 1354-1362.

22. Brough, D.E., Rice, S.A., Sell, S. and Klessig, D.F. (1985) Restricted changes in the adenovirus DNA binding protein leading to extended host range or temperature sensitive phenotypes. J. Virol. 55: 206-212.

23. Silverman, L. Anderson, K.P. and Klessig, D.F. (1985) Synthesis of the Ad2+ND5 specified 42K protein is regulated posttranscriptionally in abortively infected monkey cells. J. Virol. 56: 814-820.

24. Klockmann, U., Klessig, D.F. and Deppert W. (1985) Similar regulation of the synthesis of the human adenovirus fiber protein and of the simian virus 40 specific proteins encoded by the helper defective Ad2+SV40 hybrid viruses Ad2+ND5 and Ad2+ND4del. J. Virol. 56: 821-829.

25. Anderson, K.P., Wong, E.A. and Klessig, D.F. (1985) Microinjection of mRNA enhances the translational efficiency of human adenovirus fiber message in monkey cells. Mol. Cell. Biol. 5: 2870-2873.

26. Johnston, J. Anderson, K.P. and Klessig, D.F. (1985) Partial block to transcription of human adenovirus late genes in abortively infected monkey cells. J. Virol. 58: 378-385.

27. Rice, S.A. and Klessig, D.F. (1985) Isolation and analysis of adenovirus type 5 mutants containing deletions in the gene encoding the DNA binding protein. J. Virol. 56: 767-778.

28. Berry, J.O., Nikolau, B.J., Carr, J.P. and Klessig, D.F. (1985) Transcriptional and post-transcriptional regulation of ribulose 1,5-bisphosphate carboxylase gene expression in light and dark grown amaranthus cotyledons. Mol. Cell. Biol. 5: 2238-2246.

29. Carr, J.P., Dixon, D.C. and Klessig, D.F. (1985) The synthesis of pathogenesis-related proteins in tobacco is regulated at the level of mRNA accumulation and occurs on membrane-bound polysomes. Proc. Natl. Acad. Sci. USA 82: 7999-8003.

30. Berry, J.O., Nikolau, B.J., Carr, J.P. and Klessig, D.F. (1986) Translational regulation of light-induced ribulose 1,5-bisphosphate carboxylase gene expression of amaranth. Mol. Cell. Biol. 6: 2347-2353.

31. Klessig, D.F., Rice, S.A., Cleghon, V., Brough, D.E., Williams, J.F. and Voelkerding, K. (1986) Studies on the adenovirus DNA binding protein. In: Cancer Cells: DNA Tumor Viruses: Control of Gene Expression and Replication. Eds. T. Grodzicker, M. Botchan and P. Sharp. Cold Spring Harbor Lab. Press, Cold Spring Harbor, New York, pp. 485-496.

32. Voelkerding, K.V. and Klessig, D.F. (1986) Identification of two nuclear subclasses of the adenovirus type 5 encoded DNA binding protein. J. Virol. 60: 353-362.

33. Cleghon, V.G. and Klessig, D.F. (1986) Association of the adenovirus DNA binding protein with RNA both in vitro and in vivo. Proc. Natl. Acad. Sci. USA 83: 8 947-951.

34. Klessig, D.F., Nikolau, B.J., Carr, J.P. and Berry, J.O. (1986) Translational regulation of light-induced ribulose 1,5-bisphosphate carboxylase gene expression in amaranth. In: Translational Control. Edited by M. Mathews. Cold Spring Harbor Lab. Press, Cold Spring Harbor, New York, pp. 178-184.

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35. Rice, S.A., Klessig, D.F. and Williams, J. (1987) Multiple effects of the 72 kilodalton, Adenovirus-specified DNA binding protein on the efficiency of cellular transformation. Virol. 156: 366-376.

36. Carr, J.P., Dixon, D.C., Nikolau, B.J., Voelkerding, K.V. and Klessig, D.F. (1987) Synthesis and localization of pathogenesis-related proteins in tobacco. Mol. Cell. Biol. 7: 580-583.

37. Berry, J.O., Carr, J.P. and Klessig, D.F. (1987) Translational regulation of light- induced ribulose 1,5-bisphosphate carboxylase gene expression in amaranth. In: Progress in Photosynthesis Research, Vol. 4 . Ed. J. Biggers. Martinus Nijhoff Publishers, Dordrecht, Netherlands, pp. 565-568.

38. Nikolau, B.J. and Klessig, D.F. (1987) Coordinate, organ-specific and developmental regulation of ribulose 1,5-bisphosphate carboxylase gene expression in Amaranthus hypochondriacus. Plant Physiol. 85: 167-173.

39. Berry, J.O., Carr, J.P. and Klessig, D.F. (1988) mRNAs encoding ribulose 1,5-bisphosphate carboxylase remain bound to polysomes but are not translated in amaranth seedlings transferred to darkness. Proc. Natl. Acad. Sci. USA 85: 4190-4194.

40. Cutt, J.R., Dixon, D.C., Carr, J.P. and Klessig, D.F. (1988) Isolation and nucleotide sequence of cDNA clones for the pathogenesis-related proteins PR1a, PR1b and PR1c of Nicotiana tabacum cv. xanthi-nc induced by TMV infection. Nucl. Acids Res. 16: 9861.

41. Carr, J.P., Beachy, R.N. and Klessig, D.F. (1989) Are the PR1 proteins of tobacco involved in genetically engineered resistance to TMV? Virol. 169: 470-473.

42. Cleghon, V., Voelkerding, K., Morin, N., Delsert, C. and Klessig, D.F. (1989) Isolation and characterization of a viable adenovirus mutant defective in nuclear transport of the DNA binding protein. J. Virol. 63: 2289-2299.

43. Cutt, J.R., Harpster, M.H., Dixon, D.C., Carr, J.P., Dunsmuir, P. and Klessig, D.F. (1989) Disease response to tobacco mosaic virus in transgenic tobacco plants that constitutively express the pathogenesis-related protein PR1b. Virol. 173: 89-97.

44. Delsert, C., Morin, N. and Klessig, D.F. (1989) Cis-acting elements and a trans-acting factor affecting alternative splicing of adenovirus L1 transcripts. Mol. Cell. Biol. 9: 4364-4371.

45. Morin, N., Delsert, C. and Klessig, D.F. (1989) Nuclear localization of the adenovirus DNA binding protein: requirement for two signals and complementation during viral infection. Mol. Cell. Biol. 9: 4372-4380.

46. Morin, N., Delsert, C. and Klessig, D.F. (1989) Mutations that affect the phosphorylation of the adenovirus DNA binding protein alters its ability to enhance its own synthesis. J. Virol. 63: 5228-5237.

47. Silverman, L. and Klessig, D.F. (1989) Characterization of translational defect to fiber synthesis in monkey cells abortively infected with human adenovirus: role of ancillary leaders. J. Virol. 63: 4376-4385.

48. Silverman, L., Cleghon, V. and Klessig, D.F. (1989) Increased permissivity of monkey cells to human adenovirus multiplication is affected by culturing conditions and correlates with both synthesis of virion fiber protein and altered splicing of its mRNA. Virol. 173: 109-119.

49. Vos, H.L., Brough, D.E., van der Lee, F.M., Hoeben, R.C., Verheijden, G.F.M., Dooijes, D., Klessig, D.F. and Sussenbach, J.S. (1989) Characterization of adenovirus type 5 insertion and deletion mutants encoding altered DNA binding proteins. Virol. 172: 634-642.

50. Berry, J.O., Breiding, D.E. and Klessig, D.F. (1990) Light-mediated control of translational initiation of ribulose 1,5-bisphosphate carboxylase in Amaranth cotyledons. Plant Cell 2: 795-803.

51. Michalowski, C.B., Bohnert, H.J., Klessig, D.F. and Berry, J.O. (1990) Nucleotide sequence of rbcL from Amaranthus hypochondriacus chloroplasts. Nucl. Acid Res. 18: 2187.

52. Klessig, D.F., Cutt, J.R., Dixon, D.C., Carr, J.P., Malamy, J., Metzler, M., Harpster, M.H., Dunsmuir, P., Beachy, R.N. and Raskin, I. (1990) The PR-1 proteins - their synthesis,

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location and possible function. Workshop on Pathogenesis-Related Proteins in Plants, University Series 247. Juan March Foundation, Madrid, pp. 61-62.

53. Malamy, J., Carr, J.P., Klessig, D.F. and Raskin, I. (1990) Salicylic acid - a likely endogenous signal in the resistance response of tobacco to tobacco mosaic virus infection. Science 250: 1002-1004.

54. Coté, F., Cutt, J.R., Asselin, A. and Klessig, D.F. (1991) The pathogenesis-related acidic β-1,3-glucanase genes of tobacco are regulated by both stress and developmental signals. Mol. Plant Microbe Interact. 4: 173-181.

55. Dixon, D.C., Cutt, J.R. and Klessig, D.F. (1991) Differential targeting of the tobacco PR-1 pathogenesis-related proteins to the extracellular space and vacuoles of crystal idioblasts. EMBO J. 10: 1317-1324.

56. Metzler, M.C., Cutt, J.R. and Klessig, D.F. (1991) Isolation and characterization of a gene encoding a PR-1 like protein from Arabidopsis thaliana. Plant Physiol. 96: 346-348.

57. Chen, Z. and Klessig, D.F. (1991) Identification of a soluble salicylic acid-binding protein that may function in signal transduction in the plant disease-resistance response. Proc. Natl. Acad. Sci. USA. 88: 8179-8183.

58. Wang, J.L., Klessig, D.F. and Berry, J.O. (1992) Regulation of C4 gene expression in developing Amaranth leaves. Plant Cell 4: 173-184.

59. Eagle, P. and Klessig, D.F. (1992) A zinc binding motif located between a.a. 273-286 in the adenovirus DNA-binding protein is necessary for ssDNA binding. Virol. 187: 777-787.

60. Malamy, J., Hennig, J. and Klessig, D.F. (1992) Temperature dependent induction of salicylic acid and its conjugates during the resistance response to tobacco mosaic virus infection. Plant Cell 4: 359-365.

61. Cleghon, V. and Klessig, D.F. (1992) Characterization of the adenovirus DNA-binding protein's nucleic acid binding region by partial proteolysis and photochemical cross-linking. J. Biol. Chem. 267: 17872-17881.

62. Brough, D.E., Cleghon, V. and Klessig, D.F. (1992) Construction, characterization, and utilization of cell lines which inducibly express the adenovirus DNA-binding protein. Virol. 190: 624-634.

63. Carter, B.J., Antoni, B.A. and Klessig, D.F. (1992) Adenovirus containing a deletion of the early region 2A gene allows growth of adeno-associated virus with decreased efficiency. Virol. 191: 473-476.

64. Klessig, D. F., Malamy, J., Hennig, J., Chen, Z. and Sánchez-Casas, P. (1993) Induction, modification, and reception of the salicylic acid signal in plant defense. In: Mechanisms of Plant Defense Responses: Developments in Plant Pathology, Proceedings of the 2nd EFPP Conference, Vol. 2. Eds. B. Fritig and M. Legrand. Kluwer Academic Publishers, Dordrecht, The Netherlands, pp. 185-195.

65. Brough, D.E., Droguett, G., Horwitz, M.S. and Klessig, D.F. (1993) Multiple functions of the adenovirus DNA-binding protein are required for efficient viral DNA synthesis. Virol. 196: 269-281.

66. Cleghon, V., Piderit, A., Brough, D. and Klessig, D.F. (1993) Phosphorylation of the adenovirus DNA-binding protein and epitope mapping of monoclonal antibodies against it. Virol. 197: 564-575.

67. Hennig, J., Dewey, R.E., Cutt, J.R. and Klessig, D.F. (1993) Pathogen, salicylic acid and developmental dependent expression of a b-1,3-glucanase/GUS gene fusion in transgenic tobacco plant. Plant J. 4: 481-493.

68. Hennig, J., Malamy, J., Grynkiewicz, G., Indulski, J. and Klessig, D.F. (1993) Interconversion of the salicylic acid signal and its glucoside in tobacco. Plant J. 4: 593-600.

69. Dempsey, D.A., Wobbe, K.K. and Klessig, D.F. (1993) Resistance and susceptible responses of Arabidopsis thaliana to turnip crinkle virus. Phytopathology 83: 1021-1029.

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70. Grynkiewicz, G., Achmatowicz, O., Hennig, J., Indulski, J. and Klessig, D.F. (1993) Synthesis and characterization of the salicylic acid b-D-glucopyranoside. Pol. J. Chem. 67: 1251-1254.

71. Chen, Z., Ricigliano, J. and Klessig, D.F. (1993) Purification and characterization of a soluble salicylic acid binding protein from tobacco. Proc. Natl. Acad. Sci. USA. 90: 9533-9537.

72. Chen, Z., Silva, H. and Klessig, D.F. (1993) Active oxygen species in the induction of plant systemic acquired resistance by salicylic acid. Science 262: 1883-1886.

73. Malamy, J., Hennig, J., Sánchez-Casas, P., Grynkiewicz, G., Indulski, J. and Klessig, D.F. (1993) Role of salicylic acid in systemic acquired resistance. In: Plant Signals in Interactions with Other Organisms - Current Topics in Plant Physiology, Series 11. American Society of Plant Physiologists, Rockville, MD, pp. 230-232.

74. Klessig, D.F., Malamy, J., Hennig, J., Sánchez-Casas, P., Indulski, J., Grynkiewicz, G. and Chen, Z. (1994) Induction, modification, and perception of the salicylic acid signal in plant defense. British Biochem. Soc. Symp. 60: 219-229.

75. Ricigliano, J.W., Brough, D.E. and Klessig, D.F. (1994) Identification of a high molecular weight cellular protein complex containing the adenovirus DNA binding protein. Virol. 202: 715-723.

76. Greenberg, J.T., Guo, A., Klessig, D.F. and Ausubel, F.M. (1994) Programmed cell death in plants: a pathogen-triggered response activated coordinately with multiple defense functions. Cell 77: 551-563.

77. Sánchez-Casas, P. and Klessig, D.F. (1994) A salicylic acid-binding activity and a salicylic acid-inhibitable catalase activity are present in a variety of plant species. Plant Physiol. 106: 1675-1679.

78. Chen, Z., Malamy, J., Hennig, J., Conrath, U., Sánchez-Casas, P., Ricigliano, J., Silva, H. and Klessig, D.F. (1994) "The salicylic acid signal for activation of plant defenses is mediated by active oxygen species." In: Advances in Molecular Genetics of Plant-Microbe Interactions, Vol. 3. Eds. M. J. Daniels, J. A. Downie, and A. E. Osbourn. Kluwer Academic Publishers, The Netherlands, pp. 349-354.

79. Bowling, S.A., Guo, A., Cao, H., Gordon, A.S., Klessig, D.F. and Dong, X. (1994) A mutation in Arabidopsis that leads to constitutive expression of systemic acquired resistance. Plant Cell 6: 1845-1857.

80. Chen, Z., Malamy, J., Hennig, J., Conrath, U., Sánchez-Casas, P., Silva, H., Ricigliano, J. and Klessig, D.F. (1995) Induction, modification, and transduction of the salicylic acid signal in plant defense responses. Proc. Natl. Acad. Sci. USA. 92: 4134-4137.

81. Conrath, U., Chen, Z., Ricigliano, J.R. and Klessig, D.F. (1995) Two inducers of plant defense responses, 2,6-dichloroisonicotinic acid and salicylic acid, inhibit catalase activity in tobacco. Proc. Natl. Acad. Sci. USA 92: 7143-7147.

82. Durner, J. and Klessig, D.F. (1995) Inhibition of ascorbate peroxidase by salicylic acid and 2,6-dichloroisonicotinic acid, two inducers of plant defense responses. Proc. Natl. Acad. Sci. USA. 92: 11312-11316.

83. Conrath, U., Chen, Z., Malamy, J., Durner, J., Hennig, J., Sánchez-Casas, P., Silva, H., Ricigliano, J.W. and Klessig, D.F. (1995) The salicylic acid signal for the activation of plant disease resistance: induction, modification, perception and transduction. In: Modern Fungicides and Antifungal Compounds, 11th International Symposium, Reinhardsbrunn. Eds. H. Lyr, P.E. Russell and H.D. Sisler, Intercept Ltd. andover, UK, pp. 467-473.

84. Malamy, J., Sánchez-Casas, P., Hennig, J., Guo, A. and Klessig, D.F. (1996) Dissection of the salicylic acid signalling pathway for defense responses in tobacco. Mol. Plant-Microbe Interactions 9: 474-482.

85. Klessig, D.F., Durner, J., Chen, Z., Anderson, M., Du, H., Guo, A., Liu, Y., Shah, J. Silva, H., Takahashi, H. and Yang, Y. (1996) Studies of the salicylic acid signal transduction pathway. In: Advances in Molecular Genetics of Plant-Microbe Interactions, Vol. 4. Eds. G. Stacey, B. Mullin and P.M. Gresshoff. Kluwer Academic Publishers, The Netherlands, pp. 33-38.

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86. Shah, J. and Klessig, D.F. (1996) Identification of a salicylic acid-responsive element in the promoter of the tobacco pathogenesis-related b-1,3-glucanase gene, PR-2d. Plant J. 10: 1089-1101.

87. Yang, Y. and Klessig, D.F. (1996) Isolation and characterization of a TMV-inducible myb oncogene homologue from tobacco. Proc. Natl. Acad. Sci. USA 93: 14972-14977.

88. Durner, J. and Klessig, D.F. (1996) Salicylic acid is a modulator of tobacco and mammalian catalases. J. Biol. Chem. 271: 28492-28501.

89. Shah, J., Tsui, F. and Klessig, D.F. (1997) Characterization of a salicylic acid-insensitive mutant (sai1) of Arabidopsis thaliana, identified in a selective screen utilizing the SA-inducible expression of the tms2 gene. Mol. Plant-Microbe Interact. 10: 69-78.

90. Conrath, U., Silva, H. and Klessig, D.F. (1997) Protein dephosphorylation mediates salicylic acid-induced expression of PR-1 genes in tobacco. Plant J. 11: 747-757.

91. Dempsey, D., Pathirana, M.S., Wobbe, K.K. and Klessig, D.F. (1997) Identification of an Arabidopsis locus required for resistance to turnip crinkle virus. Plant J. 11: 301-311.

92. Du, H. and Klessig, D.F. (1997) Identification of a soluble, high affinity salicylic acid-binding protein from tobacco. Plant Physiol. 113: 1319-1327.

93. Zhang, S. and Klessig, D.F. (1997) Salicylic acid activates a 48-kD MAP kinase in tobacco. Plant Cell 9: 809-824.

94. Chen, Z., Iyer, S., Caplan, A., Klessig, D.F. and Fan, B. (1997) Differential accumulation of salicylic acid and salicylic acid-sensitive catalase in different rice tissues. Plant Physiol. 114: 193-201.

95. Takahashi, H., Chen, Z., Du, H., Liu, Y. and Klessig, D.F. (1997) Development of necrosis and activation of disease resistance in transgenic tobacco plants with severely reduced catalase levels. Plant J. 11: 993-1005.

96. Yu, D., Liu, Y., Xie, Z., Fan, B., Klessig, D.F. and Chen, Z. (1997) Is the high basal level of salicylic acid important for disease resistance in potato? Plant Physiol. 115: 343-349.

97. Du, H. and Klessig, D.F. (1997) Role of salicylic acid in the activation of defense responses in catalase-deficient transgenic tobacco. Mol. Plant-Microbe Interact. 10: 922-925.

98. Bowling, S., Clarke, J.D., Liu, Y., Klessig, D.F. and Dong, X. (1997) The cpr5 mutant of Arabidopsis expresses both salicylic acid-dependent and salicylic acid-independent resistance. Plant Cell 9: 1573-1584.

99. Wendehenne, D., Durner, J., Chen, Z. and Klessig, D.F. (1998) Benzothiadiazole, an inducer of plant defenses, inhibits catalase and ascorbate peroxidase. Phytochemistry 47: 651-657.

100. Anderson, M., Chen, Z. and Klessig, D.F. (1998) Possible involvement of lipid peroxidation in salicylic acid-mediated induction of PR-1 gene expression. Phytochemistry 47: 555-566.

101. Zhang, S., Du, H. and Klessig, D.F. (1998) Activation of the tobacco SIP kinase by both a cell wall-derived carbohydrate elicitor and purified proteinaceous elicitins from Phytophthora spp. Plant Cell 10: 435-449.

102. Zhang, S. and Klessig, D.F. (1998) The tobacco wounding-activated mitogen-activated protein kinase is encoded by SIPK. Proc. Natl. Acad. Sci. USA 95: 7225-7230.

103. Zhang, S. and Klessig, D.F. (1998) Resistance gene N-mediated de novo synthesis and activation of a tobacco mitogen-activated protein kinase by tobacco mosaic virus infection. Proc. Natl. Acad. Sci. USA 95: 7433-7438.

104. Clarke, J.D., Liu, Y., Klessig, D.F. and Dong, X. (1998) Uncoupling PR gene expression from NPR1 and bacterial resistance: The story of the dominant cpr6 mutant in Arabidopsis. Plant Cell 10: 557-569.

105. Wobbe, K.K., Akgoz, M., Dempsey, D.A. and Klessig, D.F. (1998) A single amino acid change in turnip crinkle virus movement protein p8 affects RNA binding and virulence on Arabidopsis thaliana. J. Virol. 72: 6247-6250.

106. Zhou, N., Tootle, T.L., Tsui, F., Klessig, D.F. and Glazebrook, J. (1998) PAD4 functions upstream from salicylic acid to control defense responses in Arabidopisis. Plant Cell 10: 1021-1030.

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107. Durner, J., Wendehenne, D. and Klessig, D.F. (1998) Defense gene induction in tobacco by nitric oxide, cyclic GMP and cyclic ADP ribose. Proc. Natl. Acad. Sci. USA 95: 10328-10333.

108. Guo, A., Durner, J. and Klessig, D.F. (1998) Characterization of a tobacco epoxide hydrolase gene induced during the resistance response to TMV. Plant J. 15: 647-656.

109. Conrath, U., Klessig, D.F. and Bachmair, A. (1998) Tobacco plants perturbed in the ubiquitin-dependent protein degradation system accumulate callose, salicylic acid, and pathogenesis-related protein. Plant Cell Reports 17: 876-880.

110. Citovsky, V., Ghoshroy, S., Tsui, F. and Klessig, D.F. (1998) Non-toxic concentrations of cadmium inhibit systemic movement of turnip vein clearing virus by salicylic acid-independent mechanism. Plant J. 16: 13-20.

111. Shah, J., Kachroo, P. and Klessig, D.F. (1999) The Arabidopsis ssi1 mutation restores pathogenesis-related gene expression in npr1 plants and renders defensin gene expression SA dependent. Plant Cell 11: 191-206.

112. Romeis, T., Piedras, P., Zhang, S., Klessig, D.F., Hirt, H. and Jones, J.D.G. (1999) Rapid, Avr9- and Cf-9-dependent activation of MAP kinases in tobacco cell cultures and leaves: Convergence in resistance gene, elicitor, wound and salicylate responses. Plant Cell 11: 273-287.

113. Tang, X., Xie, M., Kim., Y. J., Zhou, J., Klessig, D.F. and Martin, G.B. (1999) Overexpression of Pto activates defense responses and confers broad resistance. Plant Cell 11: 15-29.

114. Corey, A.C., Dempsey, D.A., Klessig, D.F. and Berry, J.O. (1999) Three RbcS cDNAs (Accession Nos. AF150665, AF150666, AF150667) from the C4 dicotyledonous plant Amaranthus hypochondriacus. Plant Physiol. Gene Register: #PGR99-101.

115. Silva, H., Yoshioka, K., Dooner, H.K. and Klessig, D.F. (1999) Characterization of a new Arabidopsis mutant exhibiting enhanced disease resistance. Mol. Plant-Microbe Interact. 12: 1053-1063.

116. Cooley, M., Pathirana, M.S., Wu, H.-J., Kachroo, P. and Klessig, D.F. (2000) Members of the Arabidopsis HRT/RPP8 family of resistance genes confer resistance to both viral and oomycete pathogens. Plant Cell 12: 663-676.

117. Kachroo, P., Yoshioka, K., Shah, J., Dooner, H.K. and Klessig, D.F. (2000) Resistance to turnip crinkle virus in Arabidopsis is regulated by two host genes, is salicylic acid dependent but NPR1, ethylene and jasmonate independent. Plant Cell 12: 677-690.

118. Zhao, Y., DelGrosso, L., Yigit, E., Dempsey, D.A., Klessig, D.F. and Wobbe, K.K. (2000) The amino-terminus of the turnip crinkle virus coat protein is the Avr factor recognized by resistant Arabidopsis. Mol. Plant-Microbe Interact. 13: 1015-1018.

119. Klessig, D.F., Durner, J., Zhou, J.M., Kumar, D., Navarre, R., Zhang, S., Shah, J., Wendehenne, D., Trifa, Y., Noad, R., Kachroo, P., Pontier, D., Lam, E. and Silva, H. (2000) NO and salicylic acid signaling in plant defense. Proc. Natl. Acad. Sci. USA. 97: 8849-8855.

120. Guo, A., Salih, G. and Klessig, D.F. (2000) Activation of a diverse set of genes during the tobacco resistance response to TMV is independent of salicylic acid; induction of a subset is also ethylene independent. Plant J. 21: 409-418.

121. Navarre, D., Wendehenne, D., Durner, J., Noad, R. and Klessig, D.F. (2000) Nitric oxide modulates the activity of tobacco aconitase. Plant Physiol. 122: 573-582.

122. Clark, D., Durner, J., Navarre, D.A. and Klessig, D.F. (2000) Nitric oxide inhibition of tobacco catalase and ascorbate peroxidase. Mol. Plant-Microbe Interact. 13: 1380-1384.

123. Kumar, D. and Klessig, D.F. (2000) Differential induction of tobacco MAP kinases by the defense signals nitric oxide, salicylic acid, ethylene and jasmonic acid. Mol. Plant Microbe Interact. 13: 347-351.

124. Zhang, S., Liu, Y. and Klessig, D.F. (2000) Multiple levels of tobacco WIPK activation during induction of cell death by fungal elicitins. Plant J. 23: 339-347.

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125. Petersen, M., Brodersen, P., Næsted, H., Mattsson, O., Nielsen, H.B., Lacy, M., Austin, M.J., Parker, J.E., Sharma, S.B., Klessig, D.F., Martienssen, R., Jensen, A.B. and Mundy, J. (2000) Arabidopsis MAP kinase 4 regulates systemic acquired resistance. Cell. 103: 1111-1120.

126. Mikolajczyk, M., Awotunde, O.S., Muszynska, G., Klessig, D.F. and Dobrowolska G. (2000) Osmotic stress induces rapid activation of SIP kinase and a novel 42 kD protein kinase in tobacco cells. Plant Cell 12: 165-178.

127. Liu, Y., Zhang, S. and Klessig, D.F. (2000) Molecular cloning and characterization of a tobacco MAP kinase kinase that interacts with SIPK. Mol. Plant-Microbe Interact. 13: 118-124.

128. Zhou, J.M., Trifa, Y., Silva, H., Pontier, D., Lam, E., Shah, J. and Klessig, D.F. (2000) NPR1 differentially interacts with members of TGA/OBF family of transcription factors which bind an element of the PR-1 gene required for induction by salicylic acid. Mol. Plant-Microbe Interact. 13: 191-202.

129. Klessig, D.F., Kumar, D., Navarre, R., Zhou., J.M., Shah, J., Durner, J., Zhang, S., Wendehenne, D., Kachroo, P., Trifa, Y., Silva, H., Pontier, D., Lam, E. and Noad, R. (2000) Salicylic acid- and nitric oxide-mediated signal transduction in plant disease resistance. In: Biology of Plant-Microbe Interactions 2: 13-18. Edited by P. de Witt., T. Bisseling and W. Stiekema. Kluwer Academic Publishers, The Netherlands.

130. Klessig, D.F., Navarre, R., Kumar, D., Zhou, J.M., Shah, J., Durner, J., Zhang, S., Wendehenne, D., Kachroo, P., Trifa, Y., Silva, H., Pontier, D., Lam, E. and Noad, R. (2000) Salicylic acid- and nitric oxide-mediated signaling in plant-microorganism interactions. In: 2000 Years of Natural Products Research; Past, Present and Future. Edited by T.J.C. Luijendijk, Phtoconsult, Leiden, The Netherlands, pp. 105-118.

131. Shah, J., Kachroo, P., Nandi, A. and Klessig, D.F. (2001) A recessive mutation in the Arabidopsis SSI2 gene confers SA- and NPR1-independent expression of resistance against bacterial and oomycete pathogens. Plant J. 25: 563-574.

132. Yoshioka, K., Nakashita, H., Klessig, D.F. and Yamaguchi, I. (2001) Probenazole induces systemic acquired resistance in Arabidopsis with a novel type of action. Plant J. 25: 149-157.

133. Yoshioka, K., Kachroo, P., Tsui, F., Sharma, S.B., Shah, J. and Klessig, D.F. (2001) Environmentally-sensitive, SA-dependent defense response in the cpr22 mutant of Arabidopsis. Plant J. 26: 447-459.

134. Lee, J., Klessig, D.F. and Nürnberger, T. (2001) A harpin binding site in tobacco plasma membranes mediates activation of the pathogenesis-related gene HIN1 independent of extracellular calcium but dependent on mitogen-activated protein kinase activity. Plant Cell 13: 1079-1093.

135. Kloek, A.P., Verbsky, M.L., Sharma, S.B., Schoelz, J.E., Vogel, J., Klessig, D.F. and Kunkel, B.N. (2001) Resistance to Pseudomonas syringae conferred by an Arabidopsis thaliana coronatine insensitive (coi1) mutation occurs through two distinct mechanisms. Plant J. 26: 509-522.

136. Kachroo, P., Shanklin, J., Shah, J., Whittle, E.J. and Klessig, D.F. (2001) A fatty acid desaturase modulates the activation of defense signaling pathways in plants. Proc. Natl. Acad. Sci. USA. 98: 9448-9453.

137. Klessig, D.F., Durner, J., Navarre, R., Kumar, D., Shah, J., Zhou, J.M., Zhang, S., Wendehenne, D., Kachroo, P., Silva, H., Yoshioka, K., Trifa, Y., Pontier, D., Lam, E., Chen, Z. Anderson, M. and Du, H. (2001) Salicylic acid- and nitric oxide-mediated signal transduction in disease resistance. In: Signal Transduction in Plants: Current Advances. Edited by S.K. Sopory, R. Oelmüller and S.C. Maheshwari. Kluwer Academic Plenum Publishers, The Netherlands. pp. 201-207.

138. Klessig, D.F., Kachroo, P., Slaymaker, D., Yoshioka, K., Navarre, D.A., Clark, D., Kumar, D. and Shah, J. (2001) SA- and NO-mediated signaling in plant disease resistance. Bioloy of Plant-Microbe Interactions. Eds. S.A. Long, C. Allen and W.W. Triplett. Int’l Soc. Mol. Plant-Microbe Interactions, St. Paul, MN, pp. 78-82.

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139. Slaymaker, D.H., Navarre, D.A. Clark, D., del Pozo, O., Martin, G.B. and Klessig, D.F. (2002) The tobacco salicylic acid-binding protein (SABP) 3 is the chloroplast carbonic anhydrase, which exhibits antioxidant activity and plays a role in the hypersensitive defense response. Proc. Natl Acad. Sci. USA. 99: 11640-11645.

140. Shirano, Y., Kachroo, P., Shah, J. and Klessig, D.F. (2002) A gain-of-function mutation in an Arabidopsis TIR-NBS-LRR type R gene triggers defense responses and results in enhanced disease resistance. Plant Cell 14: 3149-3162.

141. Pontier, D., Privat, I., Trifa, Y., Zhou, J-M., Klessig, D.F. and Lam, E. (2002) Post-transcriptional control of specific TGA transcription factors are differentially regulated via the proteosome pathway. Plant J. 32: 641-653.

142. Nandi, A., Kachroo, P., Fukushige, H., Hildebrand, D., Klessig, D.F. and Shah, J. (2003) Ethylene and jasmonic acid signaling affect the NPR1-independent expression of defense genes without impacting resistance to Pseudomonas syringae and Peronospora parasitica in the Arabidopsis ssi1 mutant. Mol. Plant-Microbe Interact. 16: 588-599.

143. Atkinson, R.C., Beachy, R.N., Conway, G., Cordova, F.A., Fox, M.A., Holbrook, K.A., Klessig, D.F., McCormick, R.L., McPherson, P.M., Rawlings III, H.R., Rapson, R., Vanderhoef, L.N., Wiley, J.D. and Young, C.E. (2003) Intellectual property rights: Public sector collaboration for agricultural IP management. Science 301: 174-175.

144. Kumar, D. and Klessig, D.F. (2003) The high affinity salicylic acid binding protein 2 is required for plant innate immunity and has SA-stimulated lipase activity. Proc. Natl. Acad. Sci. USA. 100: 16101-16106.

145. Kachroo, P., Kachroo, A., Lapchyk, L., Hildebrand, D. and Klessig, DF. (2003) Restoration of defective cross talk in ssi2 mutants: role of salicylic acid, jasmonic acid, and fatty acid in SSI2-mediated signaling. Mol. Plant-Microbe Interact. 16: 1022-1029.

146. Kachroo, A., Lapchyk, L., Fukushigae, H., Hildebrand, D., Klessig, D.F. and Kachroo, P. (2003) Plastidal fatty acid signaling modulates salicylic acid- and jasmonic acid-mediated defense pathways in the Arabidopsis ssi2 mutant. Plant Cell. 15: 2952-2965

147. Menke, F.L.H., van Pelt, J.A., Pieterse, C.M.J. and Klessig, D.F. (2004) Silencing of the mitogen-activated protein kinase MPK6 compromises disease resistance in Arabidopsis. Plant Cell. 16: 897-907.

148. Clark, D., Rowlett, R.S., Coleman, J.R. and Klessig, D.F. (2004) Complementation of the yeast deletion mutant DNCE103 by members of the b class of carbonic anhydrases is dependent on carbonic anhydrase activity rather than on antioxidant activity. Biochem. J. 379: 609-615.

149. Chen, Z., Kloek, A., Cuzick, A., Moeder, W., Tang, D., Innes, R., Klessig, D.F., McDowell, J., Kunkel, B. (2004) The Pseudomonas syringae type III effector AvrRpt2 funtions downstream or independently of SA to promote virulence on Arabidopsis thaliana. Plant J. 40: 494-504.

150. Jurkowski, G.I., Smith, Jr., R.K., Yu, I-c, Ham, J.H., Sharma, S.B., Klessig, D.F., Fengler, K.A. and Bent, A.F. (2004) Arabidopsis DND2, a second cyclic nucleotide-gated ion channel gene for which mutation causes the “Defense, No Death” phenotype. Mol. Plant-Microbe Interact. 17: 511-520.

151. Barth, C., Moeder, W., Klessig, D.F. and Conklin, P.L. (2004) The timing of senescence and response to pathogens is altered in the ascorbate-deficient Arabidopsis mutant vtc1. Plant Physiol. 134: 1784-1792

152. Zhou, F., Menke, F.L.H., Yoshioka, K., Moder, W., Shirano, Y. and Klessig, D.F. (2004) High humidity suppresses ssi4-mediated cell death and disease resistance upstream of MAP kinase activation, H2O2 production and defence gene expression. Plant J. 39: 920-932.

153. Chandra-Sekar, A.C., Navarre, R., Kachroo, A., Kang, H.G., Klessig, D.F. and Kachroo, P. (2004) Signaling requirements and role of salicylic acid in HRT-mediated hypersensitive response and HRT- and rrt-mediated resistance to turnip crinkle virus in Arabidopsis. Plant J. 40: 647-659

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154. Forouhar, F., Yang, Y., Kumar, D., Chen, Y., Fridman, E., Park, S.W., Chiang, Y., Acton, T.B., Montelione, G. T., Pichersky, E., Klessig, D.F. and Tong, L. (2005) Crystal structure and biochemical studies identify tobacco SABP2 as a methyl salicylate esterase and further implicate it in plant innate immunity. Proc. Nat’l. Acad. Sci. USA. 102:1773-1778.

155. Kang, H. G. and Klessig, D. F. (2005) Salicylic acid - inducible Arabidopsis CK2-like activity phosphorylates TGA2. Plant Mol. Biol. 57:541-557.

156. Moeder, W., Yoshioka, K and. Klessig, D.F. (2005) Involvement of the small GTPase Rac in the defense responses of tobacco to pathogens. Mol. Plant-Microbe Interact. 18:116-124.

157. Menke, F.L.H., Kang, H.G., Chen, Z., Park, J.K., Kumar, D., and Klessig, D.F. (2005) Transcription factor NtWRKY1 is phosphorylated by the MAP kinase SIPK and mediates HR-like cell death in tobacco. Mol. Plant-Microbe Interact. 18:1027-1034.

158. Nandi, A., Moeder, W., Kachroo, P., Klessig, D.F., and Shah, J. (2005) Arabidopsis ssi2 - conferred susceptibility to Botrytis cinerea is dependent on EDS5 and PAD4. Mol. Plant-Microbe Interact. 18:363-370.

159. Kumar, D., Gustafsson, C., and Klessig, D. F. (2006) Validation of RNAi silencing specificity using synthetic genes: salicylic acid-binding protein 2 is required for plant innate immunity. Plant J. 45:863-868.

160. Yoshioka, K., Moeder, W., Kang, H.-G., Kachroo, P., Masmoudi, K., Berkowitz, G. and Klessig, D.F. (2006) The chimeric cyclic nucleotide-gated ion channel AtCNGC11/12 activates multiple pathogen resistance responses. Plant Cell 18:747-763.

161. Chandra-Shekara, A. C., Gupte, M., Navarre, D., Raina, S., Raina, R, Klessig, D. F. and Kachroo, P. (2006) Light-dependent hypersensitive response and resistance signaling to turnip crinkle virus in Arabidopsis. Plant J. 45:320-334.

162. Klessig, D.F., Kumar, D., Forouhar, F., Tong,L., Yang,Y., Pichersky, E., Montelione, G.T., Chen,Y., Park, S.-W., Vlot, A.C., and Shulaev,V. (2007) Salicylic acid-binding protein(SABP)2 and systemic acquired resistance. Biology of Plant-Microbe Interactions, Eds. F. Sanchez, C. Quinto, I. M. Lopez-Lara and O. Geiger, Int’l Soc. for Molecular Plant-Microbe Interactions, St. Paul, MN. 5:176-181.

163. Moeder, W., del Pozo, O., Navarre, D. A., Martin, G. B. and Klessig, D. F. (2007) Aconitase plays a role in regulating resistance to oxidative stress and cell death in Arabidopsis and Nicotiana benthamiana. Plant Mol. Biol. 63:273-287.

164. Zheng, Z., Mosher, S. L., Fan, B., Klessig, D.F., and Chen, Z. (2007) Functional analysis of Arabidopsis WRKY25 transcription factors in plant defense against Pseudomonas syringae. BMC Plant Biology 7:2.

165. Jagadeeswaran, G., Raina, S., Acharya, B., Maqbool, S., Mosher, S., Appel, H., Schultz, J., Klessig, D., and Raina, R. (2007) Arabidopsis GH3-LIKE DEFENSE GENE 1 is required for accumulation of salicylic acid, activation of defense responses and resistance to Pseudomonas syringae. Plant J. 51:234-246.

166. Acharya, B., Raina, Sl, Maqbool, S., Jagadeeswaran, G., Mosher, S., Appel, H., Schultz, J., Klessig, D.F., and Raina, R. (2007) CRK13, an Arabidopsis cysteines-rich receptor-like kinase positively regulates cell death and resistance against pathogens. Plant J. 50:488-499.

167. Park, S.-W., Kaiyomo, E., Kumar, D., Mosher, S.L., and Klessig, D.F. (2007) Methyl salicylate is a critical mobile signal for plant systemic acquired resistance. Science 318:113-116.

168. Forouhar, F., Kuzin, A., Seetharaman, J., Lee, I., Zhou, W., Abashidze, M., Chen, Y., Yong, W., Janjua, H., Fang, Y., Wang, D., Cunningham, K., Xiao, R., Acton, T.B., Pichersky, E., Klessig, D.F., Porter, C.W., Montelione, G.T., and Tong, L. (2007) Functional insights from structural genomics. J. Struct and Funct Genomics. 8:37-44.

169. Zhou, F., Mosher, S., Tian, M., Sassi, G., Parker, J., and Klessig, D. F. (2008) The Arabidopsis gain-of-function mutant ssi4 requires RAR1 and SGT1b differentially for defense activation and morphological alterations. Mol. Plant-Microbe Interact. 21:40-49.

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170. Kang, H.-G., Kuhl, J. C., Kachroo, P., and Klessig, D. F. (2008) CRT1, an Arabidopsis ATPase that interacts with diverse resistance proteins and modulates disease resistance to Turnip Crinkle Virus. Cell Host & Microbe. 3:48-57.

171. Vlot, A.C., Liu, P.P., Cameron, R.K., Park, S.W., Yang, Y., Kumar, D., Zhou, F., Padukkavidana, T., Gustafsson, C., Pichersky, E., and Klessig, D.F. (2008) Identification of likely orthologs of tobacco salicylic acid-binding protein 2 and their role in systemic resistance in Arabidopsis thaliana. Plant J. 56:445-456.

172. Yang, Y., Xu, R., Ma,C-J., Vlot, A. C., Klessig, D. F., and Pichersky, E. (2008) Inactive methyl indole-3-acetic acid ester can be hydrolyzed and activated by several esterases belonging to the AtMES esterase family of Arabidopsis. Plant Physiol. 147:1034-1045.

173. Moreau, M., Lee, G.-I., Wong, Y., Crane, B.R., and Klessig, D.F. (2008) AtNOS/A1 is a functional Arabidopsis thaliana cGTPase and not a nitric oxide synthase. J. Biol. Chem. 283:32957-32967.

174. Sudhamsu, J., Lee, G.-I., Klessig, D.F., and Crane, B.R. (2008) The structure of YqeH: An AtNOS1/AtNOA1 ortholog that couples GTP hydrolysis to molecular recognition. J. Biol. Chem. 283:32968-32976.

175. Kang, H.G. and Klessig, D.F. (2008) The involvement of the Arabidopsis CRT1 ATPase family in disease resistance protein-mediated signaling. Plant Signaling & Behav. 3:689-690.

176. Kumar, D. and Klessig, D.F. (2008) The search for the salicylic acid receptor led to discovery of the SAR signal receptor. Plant Signaling & Behav. 3:691-692.

177. Jeong, R.-D., Chandra-Shekara, A. C., Kachroo, A., Klessig, D. F., and Kachroo, P. (2008) HRT-mediated hypersensitive response and resistance to Turnip crinkle virus in Arabidopsis does not require the function of TIP, the presumed guardee protein. Mol. Plant-Microbe Interact. 21:1316-1324.

178. Sekine, K.-T., Kawakami, S., Hase, S., Kubota, M., Ichinose, Y., Shat, J., Kang, H.G., Klessig, D.F., and Takahashi, H. (2008) High-level expression of a virus resistance gene, RCY1, confers extreme resistance to Cucumber mosaic virus in Arabidopsis thaliana. Mol. Plant-Microbe Interact. 21:1398-1407.

179. Park, S.-W., Liu, P.-P., Forouhar, F., Vlot, A.C., Tong, L., Tietjen, K., and Klessig, D.F. (2009) Use of a synthetic salicylic acid analog to investigate the roles of methyl salicylate and its esterases in plant disease resistance. J. Biol. Chem. 284:7307-7317.

180. Kawamura, Y., Takenaka, S., Hase, S., Kubota, M., Ichinose, y., Kanayama, Y., Nakaho, K., Klessig, D. F., and Takahashi, H. (2009) Enhanced defense responses in Arabidopsis induced by the cell wall protein fractions from Pythium oligandrum require SGT1, RAR1, NPR1 and JAR1. Plant Cell Physiol. 50:924-934.

181. Liu, P.-P., Bhattacharjee, S., Klessig, D.F., and Moffett, P. (2010) Systemic acquired resistance is induced by R gene-mediated responses independent of cell death. Mol. Plant Pathol. 11:155-160.

182. Liu, P.-P., Yang, Y., Pichersky, E., and Klessig, D.F. (2010) Altering expression of Benzoic Acid/Salicylic Acid Carboxyl Methyltransferase 1 compromises systemic acquired resistance and PAMP-triggered immunity in Arabidopsis. Mol. Plant-Microbe Interact. 23:82-90.

183. Kang, H.-G., Oh, C.-S., Sato, M., Katagiri, F., Glazebrook, J., Takahashi, H., Kachroo, P., Martin, G., and Klessig, D. F. (2010) Endosome-associated CRT1 functions early in resistance gene-mediated defense signaling in Arabidopsis and Tobacco. Plant Cell, 22:918-936.

184. Manosalva, P.M., Park, S.W., Forouhar, F., Tong, L., Fry, W.E., and Klessig, D.F. 2010. Methyl esterase 1 (StMES1) is required for systemic acquired resistance in potato. Mol. Plant-Microbe Interact. 23:1153-1163.

185. Mosher, S., Moeder, W., Nishimura, N., Jikumaru, Y., Joo, S.-H., Urquhart, W., Klessig, D. F., Kim, S.-K., Nambara, E., and Yoshioka, K. (2010) The lesion-mimic mutant cpr22 shows alterations in abscisic acid signaling and abscisic acid insensitivity in a salicylic acid-dependent manner. Plant Physiol. 152:1901-1913.

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186. Jeong, R.-D., Chandra-Shekara, A. C., Barman, S. R., Navarre, D., Klessig, D. F., Kachroo, A., and Kachroo, P. (2010) Blue-light photoreceptors are required for the stability and function of a resistance protein-mediating viral defense. Proc. Natl. Acad. Sci. USA. 107:13538-13543.

187. Liu, P.-P., von Dahl, C. C., Park, S.-W., and Klessig, D. F. (2011) Interconnection between methyl salicylate and lipid-based long-distance signaling during systemic acquired resistance in Arabidopsis and tobacco. Plant Physiol. 155:1762-1768.

188. Liu, P.-P., von Dahl, C. C., and Klessig, D. F. (2011) The extent to which methyl salicylate is required for signaling systemic acquired resistance is dependent on exposure to light after infection. Plant Physiol. 157:2216-2226.

189. Tian, M., von Dahl, C. C., Liu, P.-P., Friso, G., van Wijk, K. J., and Klessig, D. F. (2012) The combined use of photoaffinity labeling and surface plasmon resonance-based technology identifies multiple salicylic acid-binding proteins. Plant J. 72:1027-1038.

190. Kang, H.-G., Choi, H. W., von Einem, S., Manosalva, P., Ehlers, K., Liu, P.-P., Buxa, S. V., Moreau, M., Mang, H.-G., Kachroo, P., Kogel, K.-H., and Klessig, D. F. (2012) CRT1 is a nuclear-translocated MORC endonuclease that participates in multiple levels of plant immunity. Nature Comm. 3:1297 (DOI: 10.1030?ncomms2279)

191. Moreau, M., Tian, M., and Klessig, D. F. (2012) Salicylic acid binds NPR3 and NPR4 to regulate NPR1-dependent defense responses. Cell Research 22:193.

192. Mang, H.-G., Qian, W., Zhu, Y., Qian, J., Kang, H.-G., Klessig, D. F., and Hua, J. (2012) ABA deficiency antagonizes high temperature inhibition of disease resistance through enhancing nuclear accumulation of R proteins SNC1 and RPS4. Plant Cell 24:1271-1284.

193. Zheng, X.-Y., Spivey, N.W., Zeng, W., Liu, P.-P., Fu, Z.Q., Klessig, D.F., He, S.Y., and Dong, X. (2012) Coronatine promotes Pseudomonas syringae virulence in plants by activating a signaling cascade that inhibits salicylic acid accumulation. Cell Host & Microbe 11:587-596.

194. Zhu, S., Jeong, R.-D., Lim, G.-H., Yu, K., Chandra-Shekara, A. C., Navarre, D., Klessig, D. F., Kachroo, A., and Kachroo P. (2013) Double-Stranded RNA-Binding Protein 4 is required for resistance protein-mediated signaling against viral and bacterial pathogens. Cell Reports 4:1168-1184.

195. Langen, G., von Einem, S., Koch A., Imani J., Pai S. B., Manohar M., Ehlers K., Choi H. W., Mang H.-G., Bordiya Y., Stein N., Kang H.-G., Klessig D. F., and Kogel K.-H. (2014) The CRT1 subfamily of MORC ATPases Regulates Disease Resistance in Barley to Biotrophic and Necrotrophic Pathogens Plant Physiol. 164:866-878.

196. Wang, R., Rajagopalan, K., Sadre-Bazzaz, K., Moreau, M., Klessig, D.F., and Tong, L. (2014) Crystal structure of the Arabidopsis thaliana TOP2 oligopeptidase Acta Cryst F70:555-559.

197. Liao, Y., Tian, M., Zhang, H., Li, X., Xiaojian Xia, X., Zhou, J., Zhou, Y., Yu1, J., Shi K., and Klessig, D. F. (2014) Salicylic acid binding of mitochondrial alpha-ketoglutarate dehydrogenase E2, which interacts with the downstream mitochondrial electron transport chain, plays a crucial role in basal defense against TMV in tomato. New Phytologist, DOI: 10.1111/nph.13137.

198. Tian, M., Sasvari, Z., Friso, G., Rowland, E., Liu, X.-M., van Wijk, K., Nagy, P. D., and Klessig, D. F. (2015) Salicylic acid inhibits the replication of Tomato Bushy Stunt Virus by directly targeting a host component in the replication complex. Mol Plant Microbe Inter 28:379-386. DOI: 10.1094/MPMI-09-14-0259-R

199. Manohar, M., Tian, M., Moreau, M., Park, S-W., Choi, H.W., Fei, Z., Friso, G., Asif, M., Manosalva, P., von Dahl, C.C., Shi, K., Ma, S., Dinesh-Kumar, S.P., O’Doherty, I., Schroeder, F.C., van Wijk, K.J., and Klessig, D. F. (2015) Identification of multiple salicylic acid-binding proteins using two high throughput screens. Frontiers Plant Sci 5:777 DOI: 10.3389/fpls.2014.00777

200. Manosalva, P., Manohar, M., Kogel, K-H., Kang, H-G., and Klessig, D.F. (2015) The GHKL ATPase MORC1 modulates species-specific plant immunity in Solanaceae. Mol Plant Microbe Inter 28:927-942.

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201. Manosalva, P., Manohar, M., von Reuss, S.H., Chen, S., Micikas, R.J., Koch, A., Choe, A., Kaplan, F., Xiaohong Wang, X., Kogel, K-H., Sternberg, P.W., Williamson, V. M., Schroeder, F.C., and Klessig, D.F. (2015) Conserved nematode signaling molecules elicit plant defenses and pathogen resistance Nature Comm 6:7795/DOI: 10.1038/ncomms8795.

202. Choi, H.W., Tian, M., Song, F., Venereau, E., Preti, A., Park, S.-W., Hamilton, K., Swapna, G.V.T., Manohar, M., Moreau, M., Agresti, A., Gorzanelli, A., De Marchis, F., Wang, H., Antonyak, M., Micikas, R., Gentile, D.R., Cerione, R.A., Schroeder, F.C., Montelione, G.T., Bianchi, M.E., and Klessig, D.F. (2015) Aspirin's Active Metabolite Salicylic Acid Targets Human High Mobility Group Box 1 to Modulate Inflammatory Responses. Mol Med 21:526-535. DOI:10.2119/molmed.2015.00148

203. Choi, H.W., Tian, M., Manohar, M., Harraz, M.M., Park, S.-W., Schroeder, F.C., Snyder, S.H., and Klessig, D.F. (2015) Human GAPDH is a target of aspirin’s primary metabolite salicylic acid and its derivatives. PLOS ONE 10:e0143447. DOI: 10.1371/journal.pone.0143447.

204. Choi, H.W., Manohar1, M., Manosalva, P., Tian, M., Moreau, M., and Klessig, D.F. (2016) Activation of Plant Innate Immunity by Extracellular High Mobility Group Box 3 and Its Inhibition by Salicylic Acid. PLoS Pathog 12: e1005518. DOI: 10.1371/journal.ppat.1005518.

205. Bordiya, Y., Zheng, Y., Nam, J-C., Bonnard, A.C., Choi, H.W., Lee, B-K., Kim, J., Klessig, D.F., Fei, Z., and Kang, H-G. (2016) Pseudomonas infection of Arabidopsis enhances accessibility to transposon-associated chromatin, which displays physical association with MORC1. Mol Plant Microbe Inter 29:674-687.

206. Manohar, M., Choi, H.W., Manosalva, P., Austin, C.A., Peters, J.E., and Klessig, D.K. (2017) Plant and human MORC proteins have DNA modifying activities similar to type II topoisomerases, but require additional factor(s) for full activity. Mol Plant Microbe Inter 30:87-100.

Book Chapters and Reviews: Klessig, D.F. (1984) Adenovirus-Simian Virus 40 Interactions. In: The Adenoviruses. Ed. H.S. Ginsberg.

Plenum Press, New York and London, pp. 399-449. Carr, J.P. and Klessig, D.F. (1989) The Pathogenesis-Related Proteins of Plants. In: Genetic Engineering,

Principles and Methods, Vol. 11. Ed. J. K. Setlow. Plenum Press, New York, pp. 65-109. Cutt, J.R. and Klessig, D.F. (1992) Pathogenesis-Related Proteins. In: Plant Gene Research, Genes

Involved In Plant Defense. Eds. T. Boller and F. Meins Jr. Springer-Verlag, Wien and New York, pp. 209-243.

Cutt, J.R. and Klessig, D.F. (1992) Salicylic Acid, A Changing Perspective. In: Pharmaceutical Technology, Vol. 16. pp. 26-34.

Malamy, J. and Klessig, D.F. (1992) Salicylic Acid and Plant Disease Resistance. Plant J. 2: 643-654. Klessig, D.F. and Malamy, J. (1994) The Salicylic Acid Signal in Plants. Plant Mol. Biol. 26: 1439-1458. Dempsey, D.A. and Klessig, D.F. (1994) Salicylic Acid, Active Oxygen Species and Systemic Acquired

Resistance in Plants. Trends in Cell Biol. 4: 334-338. Dixon, D.C. and Klessig, D.F. (1995) Immunolocalization of Proteins in Fixed and Embedded Plant

Tissues. In: Methods in Plant Molecular Biology: A Laboratory Manual. Eds. P. Maliga, D. Klessig, A. Cashmore, W. Gruissem, and J. Varner. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, pp. 95-110.

Dixon, D.C., Cutt, J.R. and Klessig, D.F. (1995) In Situ Hybridization for the Detection of RNA in Plant Tissues. In: Methods in Plant Molecular Biology: A Laboratory Manual. Eds. P. Maliga, D. Klessig, A. Cashmore, W. Gruissem, and J. Varner. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, pp. 111-139.

Dempsey, D.A. and Klessig, D.F. (1995) Signals in Plant Disease Resistance. Bulletin de l'Institut Pasteur 93: 167-186.

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Wobbe, K.K. and Klessig, D.F. (1996) Salicylic Acid-an Important Signal in Plants. In: Signal Transduction in Plant Growth and Development . Ed. D.P.S. Verma. Springer, Wien and New York, pp. 167-196.

Durner, J., Shah, J. and Klessig, D.F. (1997) Salicylic Acid and Disease Resistance in Plants. Trends in Plant Sci. 2: 266-274.

Yang, Y., Shah, J. and Klessig, D.F. (1997) Signal Perception and Transduction in Plant Defense Responses. Genes and Dev. 11: 1621-1639.

Dempsey, D., Silva, H. and Klessig, D.F. (1998) Engineering Disease and Pest Resistance in Plants. Trends in Microbiol. 6: 54-61.

Klessig, D.F., Durner, J., Shah, J. and Yang, Y. (1998) Salicylic Acid-Mediated Signal Transduction in Plant Disease Resistance. In: Recent Advances in Phytochemistry. Eds. J. Romeo, K. Downum, and R. Verpoorte. Plenum Press, New York, pp. 119-137.

Shah, J. and Klessig, D.F. (1999) Salicylic Acid: Signal Perception and Transduction. In: Biochemistry and Molecular Biology of Plant Hormones. Eds. P.P.J. Hooykaas, M.A. Hall, and K.R. Libbenga. Elsevier, New York, pp. 513-541.

Dempsey, D., Shah, J. and Klessig, D.F. (1999) Salicylic acid and disease resistance in plants." Critical Reviews in Plant Sciences 18: 547-575.

Durner, J. and Klessig, D.F. (1999) NO as a signal in plants. Curr. Opin. in Plant Biol. 2: 369-374. Zhang, S. and Klessig, D.F. (2000) Pathogen-Induced MAP Kinases in Tobacco. In: MAP Kinases in

Plant Signal Transduction. Ed. H. Hirt. Springer-Verlag, Heidelberg, pp. 65-84. Wendehenne, D., Pugin, A., Klessig, D.F, and Durner, J. (2001) Nitric oxide: comparative synthesis and

signaling in animal and plant cells. Trends in Plant Sci. 4:177-183. Zhang, S. and Klessig, D.F. (2001) MAPK cascades in plant defense signaling Trends in Plant Sci. 6:520-

527. Ichimura, K., Shinozaki, K., Tena, G., Sheen, J., Henry, Y., Champion, A., Kreis, M., Zhang, S., Hirt, H.,

Wilson, C., Heberle-Bors, E., Ellis, B.E., Morris, P.C., Innes, R.W., Ecker, J.R., Scheel, D., Klessig, D.F., Machida, Y., Mundy, J., Ohashi, Y. and Walker, J.C. (2002) Mitogen-activated protein kinase cascades in plants: a new nomenclature. Trends in Plant Sci. 7: 301-308.

Dempsey, D.A. and Klessig, D.F. (2003) Salicylic Acid. In: Encyclopedia of Hormones, Elsevier Science (USA), pp. 321-329.

Wendehenne, D., Durner, J. and Klessig, D.F. (2004) Nitric oxide: A new player in plant signaling and defense responses. In. Curr. Opin. in Plant Biol. 7:449-455.

Kachroo, P., Chandra-Shekara, A. C. and Klessig, D. F. (2006) Plant signal transduction and defense against viral pathogens. Advances in Virus Research, Eds. K. Maramorosch and A. Shatkin Elsevier/Academic Press Vol. 66, pp.161-191.

Hanel, L.P., Nicole, M.C., Sritubtim, S., Morency, M.J., Ellis M., Ehlting, J., Beaudoin, N., Barbazuk, B., Klessig, D., Lee, J., Martin, G., Mundy, J., Ohashi, Y., Scheel, D., Sheen, J., Xing, T., Zhang, S., Seguin, A. and Ellis, B.E. (2006) Ancient signals: comparative genomics of plant MAPK and MAPKK gene families. Trends Plant Sci. 11:192-198.

Moffett, P. and Klessig, D.F. (2008) Plant resistance to viruses: Natural resistance associated with dominant genes. In Encyclopedia of Virology, 3rd Edit. (BWJ Mahy & MHV Van Regenmortel Editors), pp.170-177 Oxford: Elsevier.

Vlot, A.C., Klessig, D.F., and Park, S.W. (2008) Systemic acquired resistance: the elusive signal(s). Curr. Opin. Plant Biol. 11:436-442.

Vlot, A.C., Dempsey, D.A., and Klessig, D.F. (2009) Salicylic acid, a multifaceted hormone to combat disease. Ann. Rev. Phytopathol. 47:177-206.

Moreau, M., Lindermayr, C., Durner, J., and Klessig, D.F. (2010) NO synthesis and signaling in plants – where do we stand? Physiologia Plantarum 138:372-383.

Dempsey, D. A., Vlot, A. C., Wildermuth, M. C., and Klessig, D. F. (2011) Salicylic acid biosynthesis and metabolism. The Arabidopsis Book 9: e0156. doi: 10.1199/tab.0156

Dempsey, D. A. and Klessig, D. F. (2012) SOS – too many signals for systemic acquired resistance? Trends Plant Sci. 17:538-545.

Klessig, D. F, (2016) Newly identified targets of aspirin and its primary metabolite, salicylic acid.

Daniel F. Klessig

- 24 - 8/23/2017

DNA Cell Biol 35:1-4 doi: 10.108/dna.2016.3260 Klessig, D. F., Tian, M., and Choi H.W. (2016) Multiple targets of salicylic acid and its derivatives in plants and animals. Front. Immunol. 7:1-10 doi: 10.3389/fimmu.2016.00206. Choi, H.W. and Klessig, D.F. (2016) DAMPs, MAMPs, and NAMPs in plant innate immunity. BMC Plant Biol 16:232 doi: 10.1186/s12870-016-0921-2. Klessig, D. F. (2017) How does aspirin work in plants and humans? Frontiers for Young Minds doi: 10:3389/frym.2017.00014. Dempsey, D. A. and Klessig, D.F. (2017) How does the multifaceted plant hormone salicyle acid come disease in plants and are similar mechanisms utilized in humans? BioMed Central Biology 15:23 doi 10.1186/s12915-017-0364-8.