curriculum vitae - aupn.org - cv greenfield uchc.pdfcurriculum vitae personal data updated 2/11/2019...

CURRICULUM VITAE

PERSONAL DATA Updated 2/11/2019

Name: L. John Greenfield, Jr., M.D., Ph.D. Address: Home: 11 Talcott Mountain Rd. Simsbury, CT 06070 Office: Department of Neurology UConn Health 263 Farmington Ave., Farmington, CT 06030-5357 Phone: Home: (860) 413-2766 Mobile: (419) 346-5453 Office: (860) 679-3186 Fax: (860) 679-6555 Email: [email protected] EDUCATION High School: St. Christopher's School, Richmond, Va. 1974-1976

Diploma, (Valedictorian), 1976

Undergraduate: Yale University, New Haven, Ct., 1976- 1980 B.A. summa cum laude, History, the Arts and Letters, 1980

Graduate: University of Virginia, Charlottesville, Va., 1984-1988

Ph.D., Neuroscience, 1988 Professional: University of Virginia, Charlottesville, Va., 1981-1989 M.D., 1989 POSTDOCTORAL TRAINING

University of Virginia, Charlottesville, Va., 1/1/89 – 6/30/89

Physiology Department (Laboratory of John Hackett, Ph.D.) RESIDENCY AND FELLOWSHIP TRAINING

Internship: University of Michigan Hospitals, Ann Arbor, Michigan Department of Internal Medicine, 7/1/89 – 6/30/90

Residency University of Michigan Hospitals, Ann Arbor, Michigan

Department of Neurology, 7/1/90 – 6/30/93

Fellowship University of Michigan Medical Center, Ann Arbor, Michigan EEG and Epilepsy, Department of Neurology, 7/1/97 – 6/30/98

L. John Greenfield, Jr., M.D., Ph.D.

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OTHER TRAINING EXPERIENCE 2012 AAMC Executive Development Course for Associate Deans and Department

Chairs, Wellesley, MA, September 27-October 1, 2012. Palatucci Advocacy Leadership Forum, May 18 - 21, 2017 ACADEMIC AND ADMINISTRATIVE APPOINTMENTS

Assistant Professor, Dept. of Neurology, 7/1/93 – 5/31//99 University of Michigan, Ann Arbor, Michigan

Assistant Professor of Neurology and Pharmacology, 6/1/99 − 12/31/02

Medical College of Ohio, Toledo, OH

Associate Professor of Neurology and Pharmacology, 1/1/03 − 6/30/06 Medical University of Ohio, Toledo, OH Vice Chair for Research, Department of Neurology, 9/1/05 − 6/30/06 Medical University of Ohio, Toledo, OH Director, M.D./Ph.D. Training Program, 7/1/05 – 6/30/06 Medical University of Ohio, Toledo, OH Associate Professor of Neurology and Pharmacology, 7/1/06 − University of Toledo College of Medicine, Toledo, OH Vice Chair for Research, Department of Neurology, 7/1/06 − 6/30/10 University of Toledo College of Medicine, Toledo, OH Director, M.D./Ph.D. Training Program, 7/1/06 – 6/30/10 University of Toledo College of Medicine, Toledo, OH Professor with tenure, Dept. of Neurology, 1/1/09 - 6/30/10 University of Toledo College of Medicine, Toledo, OH Professor with tenure, Dept. of Physiology and Pharmacology, 1/1/09 - 6/30/10 University of Toledo College of Medicine, Toledo, OH Professor and Chairman, with tenure, Dept. of Neurology, 7/1/10 – 8/31/16 University of Arkansas for Medical Sciences, Little Rock, AR Professor, Dept. of Neurobiology and Developmental Science, 7/1/10 – 8/31/16 University of Arkansas for Medical Sciences, Little Rock, AR Professor and Chair, Dept. of Neurology, 9/2/16 - present University of Connecticut Health Center, Farmington, CT

MEDICAL STAFF PRIVILEGES

Medical College Hospital, Toledo, Ohio, 6/1/99 – 6/30/05

University Hospital, Toledo, Ohio, 7/1/05 - 6/30/10

St. Vincent Mercy Medical Center, Toledo, Ohio, 9/1/99 - 6/30/06


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The Toledo Hospital, Toledo, Ohio, 5/1/03 - 6/30/07 Flower Hospital, Sylvania, Ohio, 5/1/03 - 6/30/07 University of Arkansas Medical Center 7/1/10 – 8/31/16 UConn John Dempsey Hospital, 9/2/16 – present Hartford Hospital, Hartford, CT, 12/1/2017 - present LICENSURE Physician License, State of Michigan, # 4301055022, 7/1/91 - 2010 Physician License, State of Ohio, # 76214, 6/1/99 – 6/30/2010

Physician License, State of Arkansas, # E-6501, 6/4/10 – 8/31/16 Physician License, State of Connecticut, # 055487 7/18/16 - present Drug Enforcement Agency License, # BG2812952, 10/1/91 – present Connecticut State Controlled Substance Registration: CSP.0063563 UPIN F55467 NPI 1841286994; Medicaid: 1841286994 Medicare: GR0877351 IDX: 27193

BOARD CERTIFICATION American Board of Psychiatry and Neurology, Diplomate in Neurology, 1995-2005 Recertification, 2005 − 2015, 2015 - 2025

American Board of Clinical Neurophysiology, Epilepsy Monitoring Track, 2000 - 2010 American Board of Psychiatry and Neurology,

Subspecialty Certification in Clinical Neurophysiology, 2001 – 2011 Recertified 2015 - 2025

HONORS AND AWARDS AFS Summer Program Exchange Student in Bombay, India, 1976 Phi Beta Kappa, Yale University, 1979 Seymour Prize in Humanities, Berkeley College, Yale University, 1980 Honors in History, the Arts and Letters, Yale University, 1980

Medical Scientist Training Program, University of Virginia, 1981-88 Single Channel Methods Course, Cold Spring Harbor Labs (stipend), 1985

Oral Presentation, 2nd Aspen MSTP National Meeting (honorarium), 1987 Alpha Omega Alpha, University of Virginia, 1987 Whitfield Randolph Scholarship in Neuroscience, Univ. of Virginia, 1989 American Academy of Neurology Research Fellowship in Neuropharmacology 1993-96

American Epilepsy Society Junior Investigator Award (Grant) 1998-99 Epilepsy Center of Northwest Ohio Robert Wilson Award, 2004 Lamplighter Award, Epilepsy Center of Northwest Ohio, 2009 Elected to American Neurological Association 2010; Fellow status in 2012 Fellow of the American Association of Neurology, 2014 Castle Connolly Top Doctor, 2015, 2016, 2017 Faculty of the Year (Resident Teaching) Award, Department of Neurology, UAMS, 2016 Fellow of the American Epilepsy Society, 2016 Palatucci Advocacy Leadership Forum Graduate, 2017


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MEMBERSHIPS IN PROFESSIONAL SOCIETIES American Academy of Neurology, 1992 – present Fellow, 2014 - present American Association for the Advancement of Science, 1993 - present American Epilepsy Society, 1994 – present; Fellow, 2016 - present Society for Neuroscience, 1985 - present Toledo Neurological Association, 1999 – 2010 American Association of University Professors, 2005 − 2006 American Neurological Association, 2010 - present Fellow, 2012 - present Association of University Professors of Neurology, 2010 – present Councilor, 2014 – present Program Committee 2014 – present (Chair 2016 – present) Dennis Lucy Arkansas Neurological Society, 2010 – 2016 COMMITTEE AND ADMINISTRATIVE SERVICE University of Virginia Student Member, Human Research Committee (IRB), 1988-89 University of Michigan Resident Education Committee, Department of Neurology, 1990-99 House Officers Association, 1991-93 Executive Board Member, 1991-92 Vice President, 1992-93 Faculty Recruitment Committee, Department of Neurology, 1994 -95 Medical College of Ohio / University of Toledo College of Medicine

Faculty Senate Alternate, 1999 − 2007

Member, Credentials Committee, 1999 −

Chairman, 2003 −

Member, Dean’s Ad-Hoc Committee on M.D./Ph.D. Program Requirements, 1999

Deputy Chief of Neurology Service, 2000 − 2010

Member, Internal Residency Review Committee, 2000 − 2002

Review of Orthopedic Surgery Training Program, 2000

Review of Cardiology Training Program, 2002

Member, Institutional Animal Care and Use Committee, 2000 − 2001

Member, M.D./Ph.D. Committee, 2000 – 2010

Vice Chair, 2004 −2005

Chair, 2005 − 2010

Medical Director, Neurology Clinic, 2001 − 2005

Associate Director, Comprehensive Epilepsy Center, 2001 − 2010

Member, Cellular and Molecular Neurobiology Steering Committee, 2003 − 2007

Member, Medical Staff Executive Committee, 2003 – 2010

Member, President’s Research Advisory Basic Science Subcommittee, 2003 – 2004

Member, OB-Gyn Chair Search Committee, 2003 – 2004

Member, Dean of School of Medicine Search Committee, 2004 – 2005

Chair, Neuroscience Dept. Chair Search Committee, 2004 − 2005


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Member, Board of Directors, Medical College of Ohio Clinical Faculty 2004-2008

Member, Continuing Medical Education Advisory Committee, 2004 – 2010

Member, ISAC Academic Subcommittee, 2004 − 2010

Member, Medical Student Research Committee, 2005 − 2010

President, Delta Chapter of Ohio of Alpha Omega Alpha, 2005 – 2006

Councilor, Delta Chapter of Ohio of Alpha Omega Alpha, 2006 - 2009

Chair, Biomedical Sciences Graduate Executive Committee, 2006- 2010

Member, Neuroscience Department Chair Search Committee, 2007

Member, Biomedical Engineering Graduate Program Committee, 2007 – 2010

Member, UTHSC Strategic Planning Committee, 2007 - 2008

Member, Bridge Funding Grant Review Committee, UTCOM, 2008 - 2010

Member, Neurology Resident Education Committee, 2007 – 2010

Member, UT Conflict of Interest Committee, 2008 - 2010

Member, Dean’s Research Advisory Committee, 2008 – 2010

Member, UT College of Graduate Studies Dean Search Committee, 2008

Member, College of Medicine Council Constitution Committee, 2009

Co-ordinating Author of Council Bylaws

Member, University of Toledo Reaccreditation Self-Study Committee – Criterion 4, 2010

University of Arkansas for Medical Sciences

CORE Transplantation Committee (2010 - 2016)

Leadership Committee

Faculty Group Practice Board (2010 – 2016)

Best Practices Subcommittee (2010 – 2012)

External Communications Subcommittee (2010 – 2012)

Compliance Committee (2010 - 2016)

Council of Department Chairs (2010 – 2016)

PACE Committee (VA Liaison) (2010 – 2016)

Hospital Medical Board (2010 – 2016)

MD/PhD Advisory Committee (2012 - 2016)

Uconnect (Epic EMR Implementation) Committee (2012 - 2014)

Inpatient Access Committee (2015 - 2016)

UConn Health

Clinical Council (2016 - present

Clinical Chairs and Center Directors (Dean’s Round Table) (2016 - .

EVP’s Clinical Cabinet (2016 -

Neuroscience Chair Search Committee (2016 – 2017)

Academic Merit Plan Review Committee (2017 -

NATIONAL COMMITTEE/BOARD SERVICE

American Epilepsy Society Member, Investigator’s Workshop Committee, 1999 − 2001 Member. Scientific Program Committee, 2004 – 2006, 2009 – 2011 Member, Basic Science Committee, 2009 – 2011, 2013 − 14


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Member, Finance Committee, 2011 – 2015 Member, Merrit Putnam Symposium Planning Committee 2017 - American Association of Medical Colleges GREAT Medical School Representative, 2005 − 2010 Voting member, GREAT MD/PhD Section, 2005 – 2010 American Neurological Association Membership Evaluation Committee, 2011 – 2014 Abstract Review Committee, 2012 – 2014 Neurology Practice-Based Research Network Board of Directors 2016 - Amercan Board of Psychiatry and Neurology Research Award Committee, 2016 – present American Brain Coalition Board of Directors, 2017 - COMMUNITY SERVICE

Presentations on Neurology/Neuroscience to 1st and 2nd grade classes, Estabrook/New Horizons School, Ypsilanti, 1994-95

Coach, Pittsfield Township T-Ball team, 1994 Den Leader, Cub Scout Webelos, Pack 283, Ypsilanti, MI, 1998 Lectures (2 h) to Ottawa Hills Junior High School – “Neurology”, 2002 Professional Advisory Board, Epilepsy Center of NW Ohio, 2001 – 2010 Member, Board of Trustees, Epilepsy Center of Northwest Ohio, 2004-2010

Executive Director Search Committee, 2004, 2007 Chair, Professional Advisory Committee, 2005- 2010 Vice President, 2004-2006 President, 2006-2010 Foil and Epee Assistant Coach, Toledo Blades Fencing Club, 2006 – 2007 Member, Musica Antigua de Toledo early music performance group, 2006 – 2010 Medieval, renaissance and baroque lutes, viola da gamba, recorder, voice Arkansas Symphony Orchestra Board of Advisors, member, 2012 - 2016 TEACHING ACTIVITIES Invited Lectures (Selected):

4/97, 4/98 Basic Neurophysiology and Neurotransmitters (invited lecture, Dept. of Psychiatry Neurology Review Day)

5/11/98 Grand Rounds, University of Louisville: “Molecular mechanisms of antiepileptic drugs: studies of human and recombinant channels.”

5/19/98 Grand Rounds, University of Florida, Gainesville: “Molecular mechanisms of antiepileptic drugs”

10/8/98 Grand Rounds, Medical College of Ohio, Toledo, OH: “Molecular mechanisms of antiepileptic drugs”

12/16/98 Grand Rounds, University of Michigan: “Out of the Blue” (Status epilepticus due to cortical dysplasia)

12/22/98 Grand Rounds, University of Oklahoma, Oklahoma City, OK: “Molecular


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Mechanisms of antiepileptic drugs: Lessons from human and recombinant channels”

9/23/99 Grand Rounds, MCO: “The Status of Status (Epilepticus)” 11/4/00 “Neurologic Exam: Focus on the Shoulder” for 8th annual Spine

Symposium, Dept. of Orthopedics, MCO 12/18/02 “Hypoxia-induced regulation of GABAA receptor expression – a

mechanism of myoclonus?” Epilepsy Conference, Case Western Reserve University, Cleveland, OH

5/6/03 “Update on Epilepsy” for MCO Family Practice Didactic Conference 3/26/04 “Myoclonus:From Bedside to Bench and Back” at 8th Annual Hot Topics

in Neurology Symposium, MCO 6/3/05 Epilepsy Grand Rounds, Cleveland Clinic Foundation: “Post-Hypoxic

Regulation of Inhibitory Receptors.” 9/20/05 “Epilepsy in Women,” OBGyn Grand Rounds, Medical Univ. of Ohio 2/9/06 “Hypoxic Regulation of GABAA receptors.” University of Toledo College

of Pharmacy Seminar Series. 4/4/07 “Epilepsy Update”, Firelands Medical Center “Meet the Professor”,

Sandusky, OH 11/1/07 “Psychiatric Comorbidity of Epilepsy” Psychiatry Grand Rounds,

University of Toledo College of Medicine 1/5/09 “Hypoxia, Seizures and the GABA-A Receptor” Dept. of Neurology,

University of Mississippi, Jackson, MS 9/25/09 “Hypoxia, Seizures and the GABA-A Receptor” Dept of Neurology,

University of Arkansas for Medical Sciences, Little Rock, AR 12/2/10 “Lean Thinking in Healthcare” – presentation to Leadership Book Club,

UAMS 12/15/10 “Epilepsy in the Elderly.” Geriatrics Grand Rounds, Donald W. Reynolds

Institute on Aging, UAMS 2/18/11 “Epilepsy in the Elderly.” Neurology Grand Rounds, UAMS 3/24/11 “Psychiatric Issues in Epilepsy” Neurology Grand Rounds, University of

Toledo College of Medicine 4/7/11 “Hypoxia, Seizures and the GABA-A Receptor” Neuroscience Seminar

Series, Texas A&M University, College Station, TX 5/5 /11 “Hypoxia, Seizures and GABA-A Receptor” Neuroscience Research

Interest Group, UAMS 5/23/11 “Psychiatric Issues In Epilepsy” Neurology Grand Rounds, UAMS 9/30 /11 “Quality and Efficiency in Neurology Clinic” Neurology Grand Rounds,

UAMS 11/7/11 “Brave New World: Toward a Cell Therapy for Epilepsy” Keynote

Research Address, Arkansas Chapter of Society for Neuroscience Annual Meeting.

1/4/13 “Brain, Mind and the Paranormal” Neurology Grand Rounds, UAMS 3/5/13 “Psychiatric Issues In Epilepsy” AHEC Jonesboro Grand Rounds 5/7/13 “Epilepsy Update” UAMS Center for Rural Health Teleconference 7/12/13 “That Sinking Feeling: Seizures, Syncope and SUDEP” Neurology Grand

Rounds, UAMS 8/22/13 “That Sinking Feeling: Seizures, Syncope and SUDEP” Medicine Grand

Rounds, UAMS 1/3/14 “Teaching Professionalism to Neurology Residents and Students” UAMS

Neurology Grand Rounds 6/7/14 “Epileptic and Non-epileptic Seizures: A whole lot of Shaking going

on…” Neurology Update 2014 CME Symposium, UAMS 10/24/14 “Altered States: Causes of Confusion” Neurology Grand Rounds, UAMS


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1/23/15 “Up in Smoke: Cannabinoids for Epilepsy” Neurology Grand Rounds, UAMS

4/6/15 “Psychiatric Issues in Epilepsy.” Neurology Update 2015 CME Symposium, UAMS

9/16/15 “Brain Death: A Neurologist’s Perspective.” Neuroscience Nursing Didactic Conference, UAMS

2/26/16 “Reflex Epilepsies” UAMS Neurology Grand Rounds 6/10/16 “The Status of Status: An Update on Status Epilepticus” UAMS

Neurology Grand Rounds 10/6/16 “The Status of Status: an update on Status Epilepticus” Grand Rounds,

Hartford Hospital, Hartford, CT 10/25/16 “The Status of Status: An update on Status Epilepticus” Neurocritical

Care Lecture Series, UConn John Dempsey Hospital, Farmington, CT 11/17/16 “Up in Smoke: Cannabinoids for Epilepsy” Grand Rounds, Hartford

Hospital, Hartford, CT 2/3/17 “High Frequency Oscillations in Epilepsy” University of Arkansas for

Medical Sciences Neurology Grand Rounds, Little Rock, AR 10/5/17 “Eating Epilepsy: What the Reflex Epilepsies Teach Us About Seizures”

UConn/Hartford Hospital Neurology Grand Rounds 1/10/18 “Altered States: Causes of Confusion” UConn Internal Medicine CME

course lecture, Farmington CT 1/12/18 “Driving and Epilepsy” Epilepsy Foundation of Connecticut Webinar 10/21/18 “Faculty Wellness and Burnout” American Neurological

Association/AUPN Chair’s Course 11/8/18 “High Frequency Oscillations in Epilepsy” Neurology Grand Rounds,

Hartford Hospital, Hartford, CT

Medical Student Lectures (at University of Toledo): Transient Loss of Awareness (1 hr monthly to each clerkship group), 1999 – 2010 Antiepileptic Drugs (2 hrs annually to 2nd Year Systems Course), 1999 - 2010 Introduction to Seizures and Epilepsy (2 hrs annually, Systems Course), 2000-2001

Cranial Nerves (4 hrs annually to 1st Year Neuroscience Course), 2002 -2010 Hippocampus (1 hr annually, Neuroscience Course), 2000 - 2010 Introduction to EEG (Neuroscience Course, 1 h) 2010 Introduction to Sleep and its Disorders (Neuroscience Course, 1 h) 2010 Medical Student Lectures (University of Arkansas for Medical Sciences) Alzheimer’s Disease and other Dementias (2011 - 2016) Case Presentations (3 in 2011) Antiepileptic Drugs (2012 - 2015) Neurologic Examination (2013 - 2016) Resident Lectures (at University of Toledo, given in a two-year schedule, 1999 - 2010) Status Epilepticus Mechanisms of Epileptogenesis Antiepileptic Drugs

Pediatric Epilepsy Syndromes NeuroOtology Neurodevelopmental Disorders Diseases of the Cerebellum Excessive Daytime Somnolence

Parasomnias


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Neurotrauma Introduction to EEG Hypoxic/Ischemic Encephalopathy

Anatomical Basis for Disorders of Memory Neurological Examination Neuropharmacology I: Neurons, Membranes and Channels (2007 - 2010) Neuropharmacology II: Synaptic Transmission and Neurotransmitter Systems (2007-10) Alzheimer’s Disease and Other Dementias (2007 - 2010) Resident Lectures/Teaching (University of Arkansas for Medical Sciences) Morning Report (5 days per week, July 2010 – November 2011) EEG Waveforms and Generators (2010 - 2016) EEG Instrumentation and Montages (2010 - 2016) Cranial Nerves V, VII-XII (2011 - 2014) Fundamentals of Drug Therapy for Neurology (1/3/11) Epilepsy Therapy (1/17/12, 1/20/12) The Neurologic Method (September 2012) Hypothalamus and CSF analysis (February 2013) Graduate Student Lectures (at University of Toledo): Modeling the Kinetics of Ion Channels (2 hr, annually, 2000 - 2006) Metabotropic Neurotransmitter Receptors (2 h) (2007 - 2010) Electrophysiology II: Patch Clamp Recording and Analysis (2 h) (2007 - 2010) Epilepsy (Pathophysiology Graduate Course, 2 h, 2007 - 2010) Graduate Student Lectures (UAMS) Epilepsy for Basic Scientists (2 h annually, 2012 – 2016) Other Didactic Sessions: (at University of Toledo)

Neurology Journal Club (annually 1999-2010) Localization Rounds (2-3 hrs annually, 1999-2010) Greenfield/Tietz joint lab meeting (weekly, 1999 - 2010) Other lectures (selected):

Medicine Core Curriculum Lecture: Status Epilepticus (annual 2001-2009)

Neurology Grand Rounds: Mechanisms of Myoclonus, 1/17/02

Neurotrauma, given at Hot Topics Conference (unscheduled). 3/22/02

Epilepsy Lecture I for Psychiatry Residents (1 hr) 3/14/02

Epilepsy Lecture II for Psychiatry Residents (1 hr) 4/17/02

Epilepsy Summer Camp lecture for parents, Defiance, OH, 1 h, August 2002 Epilepsy Summer Camp lecture for parents, Defiance, OH, 1 h, August 2006 Epilepsy Update for Psychiatry Residents, 6/7/07 “Ask the Neurologist: Epilepsy Q and A,” Epilepsy Center of NW Ohio, 11/13/07 “Ask the Neurologist: Epilepsy Q and A,” Sylvania Public Library, 4/29/08

Epilepsy Summer Camp lecture for parents, Defiance, OH, 2 h, 8/4/2009 Program Director/Organizer: First Annual Neurology Research Day, 3/10/01 Sixth Annual Hot Topics in Neurology, “Emergency Neurology”, 3/22/02 Third Annual Neurology Research Day, 2/6/04 20th Annual MCO Graduate Student Research Forum, 4/21-22//05, Faculty Advisor Fourth Annual Neuroscience Research Day, 12/14/05


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10th Annual Hot Topics in Neurology, “Emergency Neurology”, 5/5/06 Medical Student Research Day/AOA Visiting Professorship, 9/18/06 Fifth Annual Neuroscience Research Day, 2/16/07 AOA Visiting Professorship for Dr. Kathleen Franco, 2/19/08

Sixth Annual Neuroscience Research Day, 3/14/08 Seventh Annual Neuroscience Research Day, 2/20/09 AOA visiting Professorship for Dr. Tom Wakefield, 3/4/09 AOA visiting Professorship for Dr. John Billi, 3/24/10

MENTORSHIP: Undergraduate Research Opportunity Program Students, University of Michigan: Ali Bydon - General Laboratory Techniques, 1/94 - 6/94 Jennifer Lassig - Subcloning of gfp gene into pCMVneo, 9/94 - 3/95 Leigh Ramos - Lab techniques, GABAA receptor fusion protein phosphorylation studies. Honors Biology research. 9/94 - 5/96 Matthew Germak - Lab techniques, GABAA receptor desensitization, 9/96-5/97. Medical Student Elective, University of Michigan: Susie Jun, senior medical student - Withdrawal seizure chart review, 11/96

Graduate Student Dissertation Committees, University of Michigan: Torben Neelands: Characterization of human NT2 cell GABAA receptors:

Regulation during differentiation and properties of novel isoforms, 1998.

Medical Student Research Elective, Medical University of Ohio:

Scott Lilly: Benzodiazepine regulation of AKAP in Hippocampal CA1 neurons. 2006

Summer Undergraduate Research Program, Medical College of Ohio/University of Toledo

Karen Karcher, Duke University: Synthesis and characterization of a GFP-2L GABAA receptor subunit fusion construct in a mammalian expression vector. 6-8/01, 5-7/02

Meghan Doyle, Case Western Reserve University: Effects of chronic benzodiazepines on GABAA and NMDA receptor subunit expression. 5-7/2003

Niraj Shah, University of Toledo: Effects of nifedipine on hypoxia-induced changes in GABAA receptor subunit expression, 5-7/2004

Brie Williford, Smith University: Regulation of NT2-N signaling by allopregnanolone assessed by focused microarray, 5-7/2005

Amy Ravindra, Wake Forest University. Hypoxic regulation of GABA subunit expression in NT2-N cells – role of transcription repressors 5-8/2006

Adnan Pirzada, University of Michigan. Regulation of calcineurin activity by hypoxia. 5-8/2007

Saumitra Thakur, Amherst College. A Novel Hypoxia - Seizure Rat Model. 6-8/2008 Leah Nagel, Middlebury College: Development of Hypoxia/hypoglycemia rat model

6-8/2009 Summer Medical Student Research Program, Medical College of Ohio /University of Toledo Matthew Rudloff: Effect of GHB on GABAA receptors in NT2N cells, 6-8/2000

Rebecca Pierson: Effect of steroid hormones on GABAA receptor expression and function in NT2N cells, 5-8/2001

Richard Barger: Effects of transfection of HIF-1 into NT2-N cells, 5-8/2003


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Adam Bobbey: Hypoxic regulation of NT2-N calcium signaling assessed by focused microarray, 5-8/2005

Bill Kotchkowski: Transcriptional repressors in hypoxic regulation of NT2-N cells, 5-8/2006

Sarah Reuss: Induction of HIF by lithium-pilocarpine induced status epilepticus 5-8/2007 Gregory Tomc: A novel hypoxia/hypoglycemia rat seizure model 6 - 8/2008

Undergraduate Volunteer, University of Toledo Hamid Sheiki, Amplification and purification of GABAA receptor subunit plasmids, 1-5/03 Niraj Shah, RT-PCR of NMDAR subunit changes after hypoxia. 11/03 – 3/04 Samina Bhumbra, Patch clamp recording in hippocampal neurons 5-8/2008 Other Volunteer:

Leah Nagel, 6/2006 and 11/2006, Maumee Valley Country Day School “Winterim” research project, 11/06 Emilie Lavenant, 8/08, Pharmacy Ph.D. student, Universite de Lyon Ryan Ariss, 10/08, Maumee Valley Country Day School “Winterim” research project, 10-11/08 Arjun Reddy, 10/08, Maumee Valley Country Day School “Winterim” research project, 10-11/08 Colin Yu, 11/09, Maumee Valley Countr Day School “Winterim” research project, 11/09

Graduate Student Required Laboratory Rotations, MCO/MUO/UTCOM: Lei Gao, Fall 2000

Kun Xiang, Fall 2001 Charles Pluto, Summer 2002

Adrianne Sumner, Fall 2002 Christine Willey, Fall 2002 Guofu Shen, Spring 2004 Selwyn Jayakar, Spring 2004 Liping Wang, Fall 2004

Huilin Shi, Fall 2004 Rudel Saunders, Spring 2005 Cynthia Kenmuir, Summer 2005 Damien Earl, Summer 2006 Tanuj Gulati, Fall 2006 Trisha Dwyer, Spring 2007 Laura Halpin, Summer 2008 Saurab Sharma, Fall 2008 Heng Shou, Fall 2008 Jian Wu, Spring 2009

Graduate Student Dissertation Committees, MCO/MUO/UTCOM: Qiang Nai (lab of Dr. Joseph Margiotta), 2000 − 2002 Bradley Van Sickle (lab of Dr. Elizabeth Tietz), 2000 − 2004 Yu Dong, (lab of Dr. Howard Rosenberg), 2001 − 2003

Scott Lilly (lab of Dr. Elizabeth Tietz), 2000 – 2006 Irene Wolfe (lab of Dr. Edwin Sanchez) 2005 − 2007 Kun Xiang (lab of Dr. Elizabeth Tietz) 2005 − 2007 Guofu Shen (lab of Dr. Elizabeth Tietz) 2005 – 2009 Jun Song (lab of Dr. Elizabeth Tietz) 2005 – 2007 Christine Brink (lab of Dr. David Giovannucci) 2006 - 2007


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Damien Earl (lab of Dr, Elizabeth Tietz) 2008 – 2010

Graduate Student Dissertation Major Advisor, Medical College of Ohio/University of Toledo Lei Gao, Cellular and Molecular Neurobiology Program, 2001 − 2005 Rebecca Pierson, Cell & Molecular Neurobiology and M.D./ Ph.D. program, 2002 - 2009 Liping Wang, Cellular & Molecular Neurobiology Program, 2005 – 2009 Trisha Dwyer, Neuroscience and Neurological Disorders Track, 2007 – 2011 (MS) Saurabh Sharma, Neuroscience and Neurological Disorders Track, 2009 – 2010 Graduate Student Dissertation Committees, UAMS Curtis Lowery, Biomedical Sciences Program, 2013 - 2014 Major Advisor, MSBS Program Students, University of Toledo College of Medicine Atul Ramesh, 2007. Comorbidity of Depression and Excessive Somnolence in Epilepsy. Ayesha Zaheer, 2008. Efficacy of Long Term Epilepsy Monitoring. Andrew Friedman, 2009 Development of a rat hypoxic/hypoglycemic seizure model Victor Kapoor, 2009 Clinical features of Non-epileptic seizures Kavit Shah, 2010. Behavioral analysis of epileptic and non-epileptic seizures Major Advisor, MS in Biomedical Sciences, UAMS Maryam Bashiri, 2013. Neurology Patient Telemedicine Interest in Arkansas. Post-Doctoral Trainees: Guangju Luo, MD, 2002 – 2004

Current position: Pathology resident, Univ. of Cincinnati Nathalie Boulineau, Ph.D., 2006 – 2008 Current Position: (Pharmaceutical Industry, France) Kun Xiang, MD, PhD, 2007 – 2008 Current Position: Cardiology Fellow, Dept. of Int. Medicine, Univ. of Toledo Sylvia Skalska, MD, PhD, 2009 Current Position: unknown Guofu Shen, M.D., Ph.D.: 2010 Current Position, Post-doc, University of Houston Maxim Kozhumyakin, DVM, PhD: 2011 – 2014 Current Position: Post-doctoral Researcher, University of Utah Undergraduate Lab Trainees, UAMS Clayton Davis (UNC), Summer 2012 Medical Student Lab Trainees, UAMS Be He, Summer 2011 M. Phillip Feijleh, Summer 2011 Medical Student Senior Advisees, UAMS John Cannatelli: Senior Advisor, 2013-14 Mark Farrenburg: Sleep Behavior Analysis Questionnaire, 2014 – 16 Advance Practice Nurse Preceptor Irish Grant, RN, fall 2014 Neurology Resident Mentees, UAMS Anand Patel, MD, 2010 – 2013 Shadi Yaghi, MD, 2011 – 2013 Aline Herlopian, MD, 2012 – 2013


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Eugene Achi, MD, 2012 – 2014 Undergraduate Research Volunteer, UConn Health Madeline Gregory, summer 2017: “Driving and Epilepsy Survey” UConn Medical Student Summer Research Mentees: Kristin Bumsch, 2018: “Effect of Seizure Auras on Mood in Epilepsy” SCIENTIFIC ACTIVITIES Ad-hoc reviewer:

Epilepsy Research, 1994 - present Neuropharmacology, 1995- present Journal of the American Pharmaceutical Society, 2000

Biochemical Pharmacology, 2003 Brain Research, 2004 − present Molecular Brain Research, 2004 - Journal of Pharmacology and Experimental Therapeutics, 2004 − present European Journal of Medicinal Chemistry, 2005 Molecular Pharmacology, 2005 − present Behavioral Brain Research, 2005 Experimental Neurology, 2006 − present Neuroscience, 2006 - present European Journal of Neuroscience, 2006 – present Neuroscience Letters, 2006 – present Gene Expression, 2007 Journal of Cellular Physiology, 2012 – Journal of Experimental Medicine 2012- Psychopharmacology 2013 Journal of Clinical Psychopharmacology, 2013 - Journal of Neurosciences in Rural Practice, 2013 Children, 2017

Editorial Board: Hypoxic Signalling, 2013 - Grant review panels:

Virginia Center on Aging, Alzheimer’s and Related Diseases Grant, 2001 HOP-T-29 Special Emphasis Panel: Diversity Fellowships, NIH

Ad Hoc Reviewer, March 2007 Ad Hoc Reviewer, November 2007 US Civilian Research & Development Foundation

Ad Hoc Reviewer, November 2007

Clinical Neuroscience and Disease (CND) Study Section, NIH Ad Hoc Reviewer, February 2008 Ad Hoc Reviewer, June 2008 Acute Neural Injury and Epilepsy (ANIE) Study Section, NIH Ad Hoc Reviewer, October 2008 Ad Hoc Reviewer, February 2009 Ad Hoc Reviewer , June 2009


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Acute Neural Injury and Epilepsy (ANIE) Study Section, NIH Charter Member, July 2009 – June 2015 Meetings Attended: 10/09, 2/10, 10/10, 1/11, 6/11, 2/12, 2/13, 6/13, 2/14, 6/14, 10/14, 2/15, 6/15; Scoring Validation Study 4/16. UTCOM Bridge Funding Panel:

February 2008, April 2008, December 2008

Citizens United for Research in Epilepsy (CURE) Taking Flight Awards November 2013 Arkansas Children’s Hospital Research Grant review committee: 2014-16. American Board of Psychiatry and Neurology Research Award

2016, 2017 – (annual) Extramural Reviewer, University of Illinois Department of Neurology,

January 23, 2019

Clinical Research Trials: Sub-or Co-investigator in the following trials: 1. A long term, open label, multicenter study of the safety and efficacy of ucb L059

(levitiracetam) 500 mg tablets at individualized oral doses ranging from 1000 mg/day to 4000 mg/day in the treatment of epilepsy. UCBPharma, Inc., protocol # RPCE96A2201.

2. Safety and Efficacy of High versus low dose oxcarbamazepine monotherapy in

patients with inadequately controlled partial onset seizures – Protocol 47680-02-028, CIBA Pharmaceuticals.

3. A double-blind, placebo-controlled, parallel study to evaluate the efficacy of

TOPAMAX (topiramate) compared to valproate as add-on therapy to carbamazepine with special emphasis on cognitive function in subjects with partial-onset seizures. Ortho-McNeil Pharmaceutical, Protocol CAPSS-027.

4. Gabapentin monotherapy trial: A 4-month, double-blind, dose-controlled, parallel-

group, multicenter study to determine the efficacy and safety of gabapentin in newly diagnosed patients with partial epilepsy. Parke-Davis, Protocol # 945-213-004.

5. Long-term safety and efficacy evaluation of zonisamide in the treatment of seizures in

medically refractory patients and efficacy evaluation of zonisamide monotherapy including amendment 2 (extension of treatment). Protocol #810-921.

6. A double-blind, placebo-controlled study to evaluate the safety, tolerability, and

antiepileptic activity of ganaxolone in patients undergoing evaluation to determiine suitability for surgical treatment of complex partial seizures. Protocol #1042-0104.13.

7. An open-label extension study of tiagabine HCl in the treatment of patients with

partial seizures. Protocol M91-604.

8. Clinical experience and use of Sabril in patients with partial seizures (Protocol VGPR0098) Study VGST 1235.


15

9. Safety and efficacy of high versus low dose oxcarbazepine monotherapy in patients with uncontrolled partial onset seizures (Protocol #47680-02-026). Multicenter, long-term extension phase of oxcarbazepine trial #47680-02-026 in patients with uncontrolled partial-onset seizures (Protocol #47680-02-026E).

10. A comparator dose-controlled, ascending multiple dose safety and tolerability study of

remacemide hydrochloride as an adjunctive therapy in refractory patients with epilepsy (Protocol #134) Astra Merck, Inc.

11. Safety and efficacy of high versus low dose rufinamide monotherapy in patients with

inadequately controlled partial seizures (Protocol # 3310101016) Novartis.

12. A multicenter, double-blind, placebo-controlled, randomized, stratified, parallel-group trial of rufinamide as adjunctive therapy in patients with inadequately primary generalized tonic-clonic seizures (Protocol # 3310101018) Novartis.

13. A multicenter, double-blind, placebo-controlled, randomized, stratified, parallel-

group trial of rufinamide as adjunctive therapy in children and adults with inadequately controlled partial seizures (Protocol # 3310101021, Novartis; E2080-A001-302 Eisai).

14. Keppra Epilepsy Evaluation of Patient Time to Response (KEEPER) trial. (Protocol

# RPCE00A1201). UCB Pharma.

15. Pregabalin BID Add-on Titration Trial: A randomized, double-blind, placebo-controlled, parallel-group, multicenter study in patients with partial seizures. (Protocol # 1008-145-002) Warner Lambert.

16. A multicenter, open label pilot study of lamotrigine as adjunctive therapy and

monotherapy in patients with epilepsy and comorbid depressive symptoms. (Protocol # LAM40117) Glaxo Smith Kline.

17. A multicenter, double-blind, randomized, placebo controlled, parallel-group trial to

investigate the efficacy and safety of SPM 927 (400 and 600mg/day) as adjunctive therapy in subjects with partial seizures with or without secondary generalization. (Trial # SP754, SP902, SP904). Schwartz Biosciencees.

18. Randomized, parallel group comparison of treatment with pharmacotherapy or

adjunctive vagus nerve stimulation therapy for pharmacoresistent partial seizures in patients who are not candidates for resective epilepsy surgery: A large simple effectiveness trial. (Protocol E21) Cyberonics.

19. A randomized, double blind placebo-controlled multicenter parallel group phase 3

trail to determine the efficacy and safety of Retigabine (1200 mg/d) used as adjunctive therapy in refractory epilepsy patients with partion-onset seizures. (VRX-RET-E22-301) Valeant Pharmaceuticals.

20. A 52-week, open label, randomized, parallel group, multicenter trial comparing the

efficacy, safety and tolerability of levetiracetam monotherapy vs. phenytoin monotherapy when used to treat patients with newly or recently diagnosed partial or generalized epilepsy. UCB Pharma N01195, N01280, N01281.


16

21. A double-blind, placebo-controlled, dose escalation, parallel group study to evaluate the efficacy and safety of E2007 (Perampanel) given as adjunctive therapy in subjects with refractory partial seizures. E2007-G000-307-01 Eisai.

22. A randomized, double-blind, parallel-group, multicenter study to evaluate the

retention rate, efficacy, safety, and tolerability of carisbamate, topiramate and levetiracetam as adjunctive therapy in subjects with partial onset seizures. (CARISEPY3007) Ortho-McNeil Janssen

At University of Arkansas for Medical Sciences:

23. An Open-Label Extension Phase of the Double-Blind, Placebo-Controlled, Dose-

Escalation, Parallel- Group Study of E2007 (perampanel) as an Adjunctive Therapy in Patients with Refractory Partial Seizures. Funded by Eisai Inc., (Study # E2007-A001-207). Role: Sub-investigator. Dates: July 2010 – July 2016

24. A Historical-controlled, Multicenter, Double-blind, Randomized Trial to Assess the Efficacy and Safety of Conversion to Lacosamide 400mg/day Monotherapy in Subjects with Partial-onset Seizures. Funded by SCHWARZ BIOSCIENCES, (Study # SP902). Role: Site Principal Investigator. Dates: September 2011 – July 2016. (Subinvestigator from 7/1/2010 – 8/21/2011).

25. A Multicenter, Open-label Extension Trial to Assess the Long-term Use of Lacosamide Monotherapy and Safety of Lacosamide Monotherapy and Adjunctive Therapy in Subjects with Partial-onset Seizures. Funded by SCHWARZ BIOSCIENCES, (Study # SP904). Role: Site Principal Investigator. Dates: September 2011 – Present. (Subinvestigator from 7/1/2010 – 8/21/2011).

26. Multicenter, Double-Blind, Randomized, Placebo-Controlled, Three-Arm, Parallel

Group Study to Evaluate the Efficacy and Safety of Oxcarbazepine Extended-Release (OXC XR) (1200mg/day, and 2400mg/day) as Adjunctive Therapy in Subjects with Refractory Partial Seizures due to Epilepsy on up to Two Concomitant Antiepileptic Medications. Funded by Supernus Pharmecuetical, Inc., (Study # 804P301). Role: Subinvestigator, 7/1/2010 – 8/31/2011.

27. Multicenter, Open-Label Extension Study to Evaluate the Long-Term Safety and Tolerability of Oxcarbazepine Extended-Release (OXC XR) as Adjunctive Therapy in Subjects with Refractory Partial Epilepsy on up to Two Concomitant Antiepileptic Medications. Funded by Supernus Pharmecuetical, Inc., (Study # 804P302). Role: Subinvestigator. Dates: 7/1/2010 – July 2016.

28. Double-Blind, Randomized, Historical Control Study of the Safety and Efficacy of

Eslicarbazepine Acetate Monotherapy in Subjects with Partial Epilepsy Not Well Controlled by Current Antiepileptic Drugs. Funded by Sunovion, (Study # 093-046). Role: Subinvestigator. Dates: December 2010 – July 2016

29. Long Term Eslicarbazepine Acetate Extension Study. Funded by Sunovion, (Study # 093-050). Role: Subinvestigator. Dates: January 2011 – July 2016.

30. A Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Multi-Center

Trial of Pregabalin Controlled Release Formulation as Adjunctive Therapy in Adults With Partial Onset Seizures. Funded by Pfizer, Inc, (Study # A0081194). Role: Sub-investigator. Dates: February 2011 – July 2016.


17

31. A Double-blind, Randomized, Placebo-controlled, Multicenter, Parallel-group Study

with an Open-label Extension Phase to Evaluate the Efficacy and Safety of Adjunctive Perampanel in Primary Generalized Tonic-Clonic Seizures. Funded by Eisai (Study # E2007-G000-332). Role: Subinvestigator. Dates: October 2011 – July 2016.

32. A Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Efficacy

of Intranasal Midazolam (USL261) in the Outpatient Treatment of Subjects with Seizure Clusters. ARTEMIS- I: Acute Rescue Therapy in Epilepsy with Midazolam Intranasal Spray-I. Role: Site Principal Investigator. Dates: February 2013 – July 2016.

At UConn Health:

33. SEP093-701: Efficacy and Safety of Eslicarbazepine Acetate as First Add-on to

Levetiracetam or Lamotrigine Monotherapy or as Later Adjunctive Treatment for

Subjects with Uncontrolled Partial-onset Seizures: A Multicenter, Open-label, Non-

randomized Trial. Sunovion. Role: Site PI. May 2018 - .

34. Detection of Biomarkers of Mild, Moderate and Severe Traumatic Brain Injury.

Perseus Science Group LLC. Role: Site PI. In development.

GRANT SUPPORT

Regulation of Cloned GABAA Receptors by Phosphorylation, Clinical Investigator Development Award (NINDS 1K08 NS 01654). Mentor: Dr. Robert L. Macdonald.

Total costs: $432,000. July 1, 1993 - June 30, 1998; no-cost extension through 5/31/99.

Effects of Phosphorylation on GABAA Receptor Pharmacology and Channel Function.

American Academy of Neurology Neuropharmacology Fellowship Award. $82,000.

July 1, 1993 – June 30,1996.

Regulation of Enteric GABAA Receptors by Protein Kinases. GI Peptide Research Center

Pilot Grant: $15,000. September 1, 1996 - August 31, 1997

Anticonvulsant Drug Actions on GABAA Receptors and Sodium Channels of Human

Clonal NT2-N Neurons. Epilepsy Foundation of America Junior Investigator Grant.

$40,000. July 1, 1998–June 30, 1999.

Post-hypoxic changes in GABAA receptor function and subunit expression in human NT-

2 neurons in vitro. Myoclonus Research Foundation, $65,500, July 1, 2001 – June 30,

2002. Second year funding: $70,000, July 1, 2002 – June 30, 2003. Third Year funding

$94,800, July 1, 2003 – June 30, 2004.

Research Fellowship for Guangju Luo. Pfizer, Inc. Unrestricted Educational Grant

$10,800. 10/1/02 – 9/30/03.


18

Effects of Levetiracetam on GABAA Receptors in Human NT2-N Neurons. UCB

Pharma Research Grant. Total costs: $ 78,281, July 1, 2004 - June 30, 2005.

Regulation of GABA-A Receptors by Gonadal Steroids in NT2-N Cells. Epilepsy

Foundation of America Predoctoral Grant to Rebecca Pierson (Greenfield as Mentor).

Total costs: $20,000. July 1, 2005 – June 30, 2006.

Benzodiazepine-induced Glutamate Receptor Plasticity. R01-DA018342-01A1

(Elizabeth Tietz, P.I., Greenfield 5% effort) NIDA: Direct costs $200,000 annually.

4/1/05 – 3/31/10 Post-Hypoxic Regulation of GABA-A Receptor Function. R01-NS049389-01A1. NINDS, (priority score 121, 0.9 percentile). Total costs: $266,940 annually (Direct costs: $180,000 annually). 1/1/06 – 12/31/2010, No cost extension through

12/31/12.

Neurosteroid Mechanisms in Catamenial Epilepsy. Translational Research Stimulation Award, University of Toledo College of Medicine. Total costs: $50,000 annually. 1/1/07 – 12/31/08. Telehealth Equipment Grant: Center for Distance Health, University of Arkansas for Medical Sciences, awarded January 2012. Unit value: approx.. $30,000. RII Track-2 FEC- Probing and Understanding the Brain: Micro and Macro Dynamics of Seizure and Memory Networks. August 1, 2016 – August 31, 2016 NSF EPSCoR grant (L. Iassemides, primary site PI at Louisiana Tech, Greenfield site PI at UAMS). Direct costs to all institutions $1M annually; local contract $173,000. Relinquished due to move to UConn Health.

BIBLIOGRAPHY Peer-Reviewed Papers

1. Stringer JT, Greenfield LJ, Hackett JT, Guyenet PG. Blockade of long-term potentiation by

phencyclidine and sigma opiates in the hippocampus in vivo and in vitro, Brain Research

1983; 280:127-138.

2. Hackett JT, Greenfield LJ.: The behavioral role of the Mauthner neuron impulse, Brain

Behav Science 1986; 9:729-731.

3. Hackett JT, Cochran SL, Greenfield LJJ. Quantal transmission at Mauthner axon target

synapses in the goldfish brainstem. Neuroscience 1989; 32:49-64.

4. Hackett JT, Cochran SL, Greenfield LJJ, Brosius DC, Ueda, T. Synapsin I injected

presynaptically into the goldfish Mauthner axon reduces quantal synaptic transmission. J

Neurophysiol 1990; 63:701-706.


19

5. Greenfield LJJ, Linden J, Hackett JT. Xenopus oocyte K+ current:I. FSH and adenosine

stimulate follicle cell-dependent currents. Am J Phys (Cell Physiol) 1990; 259:C775-C783.

6. Greenfield LJJ, Linden J, Hackett JT. Xenopus oocyte K+ current:II. Adenylyl cyclase-

linked receptors on follicle cells. Am J Phys (Cell Physiol) 1990; 259:C784-C791.

7. Greenfield LJJ, Hackett JT, Linden JT. Xenopus oocyte K+ current: III. Phorbol esters and

pH regulate current at gap junctions. Am J Phys (Cell Physiol) 1990; 259:C792-C800.

8. Weiss DJ, Greenfield LJ, O'Rourke K, McCune J. Systemic cytomegalovirus infection

mimicking an exacerbation of Wegener's granulomatosis. J Rheumatol 1993; 20:155-157.

9. Greenfield LJJ, Chimowitz MI, Quint, D, Wakefield TW. Contralateral reperfusion injury

after carotid endarterectomy. J Stroke Cerebrovasc Dis 1994; 4:203-6.

10. Kume A, Greenfield LJJ, Macdonald RL, Albin RL. Felbamate inhibits [3H]t-butylbicyclo-

orthobenzoate binding and enhances Cl- current at the −aminobutyric acidA receptor. J

Pharmacol Exp Therap 1996; 277(3):1-9.

11. Greenfield LJJ, Macdonald RL. Whole cell and single channel S GABAA receptor

currents elicited by a “multipuffer” drug application device. Pflüger’s Archiv 1996;

432:1080-1090.

12. Greenfield LJJ, Sun F, Neelands TR, Burgard EC, Donnelly JL, Macdonald RL. Expression

of functional GABAA receptors in transfected L929 cells isolated by immunomagnetic bead

separation. Neuropharmacol 1997; 36(1):63-73.

13. Neelands TR, Greenfield LJJ, Zhang J, Turner RS, Macdonald RL. GABAA receptor

pharmacology and subtype mRNA expression in human neuronal NT2-N cells. J Neurosci

1998; 18(13):4993-5007.

14. Greenfield LJJ, Blaivas M, Drury I. De novo status epilepticus due to multiple cerebral

hamartomas. Neurology 1999 53:53-54.

15. Greenfield LJJ, Zaman SH, Sutherland ML, Lummis S, Niemeyer MI, Barnard EA,

Macdonald RL. Mutation of the invariant proline in the M1 transmembrane segment of the

GABAA receptor subunit increases GABA affinity and reduces barbiturate enhancement.

Neuropharmacology 2002, 42:502-521.

16. Van Sickle BJ, Cox AS, Schak, K, Greenfield LJJ, Tietz EI. Chronic benzodiazepine

administration alters hippocampal CA1 neuron excitability: NMDA receptor function and

expression. Neuropharmacology 2002, 43:595-606.


20

17. Gao L, Lyons, AR, Greenfield LJJ. Hypoxia alters GABAA receptor function and subunit

expression in NT2-N neurons. Neuropharmacology 2004, 46:318-330.

18. Gao L, Greenfield LJ. Activation of protein kinase C reduces benzodiazepine potency at

GABAA receptors in NT2-N neurons. Neuropharmacology 2005, 48:333-342.

19. Pierson RC, Lyons AR, Greenfield LJ. Gonadal steroids regulate GABAA receptor subunit

mRNA expression in NT2-N neurons. Molecular Brain Research, 2005, 138:105-115.

20. Koffman BM, Greenfield LJ Jr, Ali II, Pirzada NA. Neurological complications after

surgery for obesity. Muscle and Nerve, 33:166-176, 2006.

21. Song J, Shen G, Greenfield LJ Jr, and Tietz EI Benzodiazepine withdrawal-induced

glutamatergic plasticity involves upregulation of GluR1-containing AMPA Receptors in

hippocampal CA1 Neurons. J Pharmacol Exp Ther 2007, 322(2):569-81.

22. Xiang K, Earl D, Davis KM, Giovannucci DR, Greenfield LJ Jr, Tietz EI. Chronic

benzodiazepine administration potentiates high voltage-activated calcium currents in

hippocampal CA1 neurons. J Pharmacol Exp Ther 2008, 327:1–12.

23. Wang L, Greenfield LJ Jr. Post-hypoxic changes in rat cortical neuron GABAA receptor

function require L-type voltage-gated calcium channel activation. Neuropharmacology

2009, 56:198-207.

24. Phelan KD, Mock MM, Kretz O, Shwe UT, Kozhemyakin M, Greenfield LJ, Dietrich A,

Birnbaumer L, Freichel M, Flockerzi V, Zheng F. Heteromeric TRPC1/TRPC4 channels

play a critical role in epileptiform burst firing and seizure-induced neurodegeneration. Mol

Pharmacol 2012, 81:384-392.

25. Xiang K, Behrle BL, Elizabeth I. Tietz EI, Greenfield LJ. Hypoxia enhances high-voltage-

activated calcium currents in rat primary cortical neurons via calcineurin. Epilepsy Research

2012, 99:293-305.

26. He Z, He B, Behrle BL, Fejleh MPC, Cui L, Paule MG, Greenfield LJ. Ischemia-induced

increase in microvascular phosphodiesterase 4D expression in rat hippocampus associated

with blood brain barrier permeability: Effect of age. ACS Chemical Neuroscience 2012 Jun

20;3(6):428-32.

27. He Z, Ferguson SA, Cui L, Greenfield, Jr. LJ, Paule MG. Role of neural stem cell activity in

postweaning development of the sexually dimorphic nucleus of the preoptic area in rats.

PLOS One 2013, 8(1): e54927. doi:10.1371/journal.pone.0054927.

28. He Z, Ferguson SA, Cui L, Greenfield LJ, Paule MG. Development of the sexually

dimorphic nucleus of the preoptic area and the influence of estrogen-like compounds.

Neural Regen Res. 2013 Oct 15;8(29):2763-74..


21

29. Shihabuddin BS, Herlopian AS, Greenfield LJ Jr. Ictal asystole in epilepsy patients

undergoing inpatient video-EEG monitoring. Neurosciences (Riyadh). 2014 Oct;19(4):317-

21.

30. Phelan, KD, Shweb UT, Williams DK, Greenfield LJ, Zheng F: Pilocarpine-induced Status

Epilepticus in Mice: A comparison of spectral analysis of electroencephalogram and

behavioral grading using the Racine scale. Epilepsy Research 2015, 117:90-6, DOI:

10.1016/j.eplepsyres.2015.09.008

31. Bashiri M, Greenfield, LJ, Oliveto A. Telemedicine interest for routine follow-up care

among neurology patients in Arkansas. Telemedicine and e-Health, 2016 Jun;22(6):514-8.

32. Kang Y-J, Lewis HES, Young MW, Govindaiah G, Greenfield Jr LJ, Garcia-Rill E, Lee SH.

Cell type-specific intrinsic subthreshold oscillations in hippocampal GABAergic

interneurons. Neuroscience 2018, in press.

33. Govindaiah G, Kang Y-J, Smashey-Lewis HE, Chung L, Greenfield Jr LJ, Garcia-Rill E,

Sang-Hun Lee S-H. Group I metabotropic glutamate receptors generate two types of

intrinsic membrane oscillations in hippocampal O-LM interneurons. Neuropharmacology

2018, in press.

Chapters, Reviews, Letters and Commentary

1. Greenfield LJJ, Brumbach B. Rabies. For Kids Sake 1986; 4(2):2.

2. Greenfield LJJ, Brumbach B. Snake bite. For Kids Sake 1986; 4(2):2.

3. Greenfield LJJ, Albers JA. Nitric oxide-induced motor neuron disease. (Letter) New Engl J

Med 1995; 333(8): 522-3.

4. Macdonald RL, Greenfield LJJ. Mechanisms of action of new antiepileptic drugs. Curr

Opin Neurol 1997; 10 (2):121-128.

5. Greenfield LJJ. Basic Neurophysiology. In: Labanowski M, ed, Neurology Pearls of

Wisdom. Boston, MA: Boston Medical Publishing 1998, pp 10-20.

6. Greenfield LJJ. Contributing author, Neurology Pearls. In Lenhardt R, Adler J, Plantz S,

Zevitz M, eds. Critical Care Pearls of Wisdom. Boston, MA: Boston Medical Publishing

1998, pp. 188-208.

7. Greenfield LJJ. Contributing author, Neurology Pearls. In Zevitz M, Plantz SH, Adler J, eds.

Internal Medicine Medical Student Pearls of Wisdom, USMLE parts II and III. Boston, MA:

Boston Medical Publishing 1998, pp. 147-166.


22

8. Greenfield LJJ. Contributing author, Internal Medicine Pearls: Neurology. In Zevitz M,

Plantz S, Adler J, eds. Internal Medicine Pearls of Wisdom. Boston, MA: Boston Medical

Publishing 1998, pp. 129-155.

9. Greenfield LJJ. Slow Codes (Letter). New Engl J Med 1998; 333(26):1921-22.

10. Greenfield LJJ. New drugs and therapies for epilepsy. Epilepsy Center of Northwest Ohio

Torchlight 2000, 13(2):9-10.

11. Greenfield LJJ, Rosenberg HC. “Short-Acting and Other Benzodiazepines” in Shorvon, et

al., eds. The Treatment of Epilepsy, 2nd Ed. London: Blackwell Science Ltd. 2003, pp.

374-390.

12. Greenfield LJJ, Rosenberg HC, Homan RW. “Benzodiazepines” in Wyllie E., ed., The

Treatment of Epilepsy: Principles and Practice, 4th Ed. Philadelphia: Lippincott, Williams

and Wilkins. 2006, pp. 829-854.

13. Greenfield LJJ. “Barbiturates” in Drugs and Society, vol 1. London: Marshall Cavendish,

2006, pp 118-122.

14. Greenfield LJJ. “Pharmacokinetics” in Drugs and Society, vol 3. London: Marshall

Cavendish, 2006, pp 669-675.

15. Greenfield LJJ. “Pentobarbital” in Drugs and Society, vol 3. London: Marshall Cavendish,

2006, pp 664-665.

16: Greenfield LJJ. “Secobarbital” in Drugs and Society, vol 3. London: Marshall Cavendish,

2006, pp. 770-771.

17. Greenfield LJJ. “Epilepsy surgery: when drugs aren’t enough.” Epilepsy Center of

Northwest Ohio Torchlight, Winter 2005, p. 7.

19. Greenfield LJJ. “Epilepsy program at MUO certified by JCAHO.” Epilepsy Center of

Northwest Ohio Torchlight, Summer 2005.

20. Greenfield LJ. “Recording the EEG” in Greenfield, LJ, Geyer, J, Carney P. “Reading

EEGs: A Practical Approach.” Lippincott Williams Wilkins, 2009.

21. Greenfield LJ. “Approaching the EEG” in Greenfield, LJ, Geyer, J, Carney P. “Reading

EEGs: A Practical Approach.” Lippincott Williams Wilkins, 2009.

22. Kaplan, P.W. and Greenfield, LJ “Status Epilepticus EEG Patterns in Adults.” in

Greenfield, LJ, Geyer, J, Carney P. “Reading EEGs: A Practical Approach.” Lippincott

Williams Wilkins, 2009.


23

23. Misulis KE, Greenfield LJJr “Evoked Potentials” in Greenfield, LJ, Geyer, J, Carney P.

“Reading EEGs: A Practical Approach.” Lippincott Williams Wilkins, 2009.

24. Greenfield LJJ, Rosenberg HC, Tietz, E.I.. “Benzodiazepines” in Wyllie E., ed., The

Treatment of Epilepsy: Principles and Practice, 5th Ed. Philadelphia: Lippincott, Williams

and Wilkins. 2011, pp. 668-689.

25. Greenfield Jr LJ. “Molecular Mechanisms of Antiseizure Drugs at GABAA Receptors.”

Seizure, Seizure. 2013 May 14. doi:pii: S1059-1311(13)00114-3.10.1016/ j.seizure.

2013.04.015..

26. Greenfield LJJ, Sahaya K, Shihabuddin B, Tietz, EI, Rosenberg HC. “Benzodiazepines” in

Wyllie E., ed., The Treatment of Epilepsy: Principles and Practice, 6th Ed. Philadelphia:

Lippincott, Williams and Wilkins. 2015, pp 593-615.

27. Greenfield, LJ. “Commentary: Topiramate for epilepsy in a rural population.” J Neurosci

Rural Pract. 2014 Apr;5(2):149-50.

28. Greenfield LJ, Synowiec A. “Commentary: Forced thinking about hypercognitive seizures.”

Epilepsy Research 2017, 134:62, 05-Jun-2017 DOI information:

10.1016/j.eplepsyres.2017.02.014

29. Greenfield Jr. LJ, Lee SH. “Physiologic Basis of Epileptic EEG Patterns” in Epilepsy

Diagnosis and Management: State of the Art. Spanaki-Varelas M, Wasade V., eds.

Submitted.

30. Greenfield LJJ, Sahaya K, Shihabuddin B, Tietz, EI, Rosenberg HC. “Benzodiazepines” in

Wyllie E., ed., The Treatment of Epilepsy: Principles and Practice, 7th Ed. Philadelphia:

Lippincott, Williams and Wilkins. 2018, pp. In preparation.

Books Authored or Edited

Greenfield, LJ, Geyer, J, Carney P, eds. “Reading EEGs: A Practical Approach.” Lippincott

Williams Wilkins, 2009.

Greenfield, LJ, Geyer, J, Carney P, eds. “Reading EEGs: A Practical Approach, 2nd Edition”

Wolters-Kluwer, 2019, in preparation.

Abstracts, Preliminary Communications, Panel Discussions

1. Hackett JT, Greenfield LJJ. Mauthner axon-evoked inhibition of an identifiable follower

neuron requiring an unusual synaptic mechanism. Soc Neurosci Abstr 1985; 11:148.


24

2. Greenfield LJJ, Hackett JT, Williams EH. Biochemical correlates of serotonin receptors

induced by brain mRNA in Xenopus oocytes, J Cell Biol 101:133, 1985.

3. Greenfield LJJ, Williams EH, Vandenberg SR, Hackett JT. Serotonin receptors induced by

brain mRNA in Xenopus oocytes are pharmacologically distinct from muscarinic and

dopamine receptors. Soc Neurosci Abstr 1986; 12:424.

4. Hackett JT, Cochran SL, Greenfield LJJ. Quantal features at Mauthner axon synapses in the

goldfish. Soc Neurosci Abstr 1986; 12:29a.

5. Hackett JT, Cochran SL, Greenfield LJJ, Ueda T. Decrease in available quanta by

dephosphosynapsin I injected presynaptically into the goldfish Mauthner axon. Soc Neurosci

Abstr 1987; 13:1239.

6. Greenfield LJJ, Lynch KR, Hackett JT. Functional angiotensin receptors induced in Xenopus

oocytes by injected mRNA. Soc Neurosci Abstr 1987; 13:1022.

7. Greenfield LJJ, Linden J, Hackett JT. Localization of adenosine, beta adrenergic and FSH

receptors of Xenopus "oocytes" to follicle cells, Fed Proc 1987; 46:1133a.

8. Greenfield LJJ, Hackett JT, Linden J. The Xenopus oocyte as a model for interactions

between adenylate cyclase- and phosphatidyl inositide- linked receptors. Second Annual

M.D./Ph.D. Student Conference, Aspen, Colo, 1987.

9. Greenfield LJJ, Glanzman R, Siegel GS. Multiple intracranial mass lesions in a migrant

farm worker: a case report. Michigan Neurological Association Annual Meeting, 1990.

10. Weiss DJ, Greenfield LJ, O'Rourke K, McCune J. Systemic cytomegalovirus infection

mimicking a flare of Wegener's granulomatosis. American College of Physicians Michigan

Regional Meeting, 1991.

11. Lin YF, Greenfield LJJ, Browning MD, Macdonald RL. Protein kinase C inhibits rundown

of GABAA receptor currents in mouse cortical neurons and transfected L929 cells. Soc

Neurosci Abstr 1992; 18:1161.

12. Greenfield LJJ, Browning MD, Macdonald RL. Protein kinase C decreases rundown of

GABAA receptor currents in cultured mouse cortical neurons. Neurology 1993; 43:A365.

13. Kapur J, Greenfield LJJ, Macdonald RL. Anticonvulsant effects on dentate granule cell

GABAA receptor currents. Epilepsia 1994; 35(Suppl.8): 44.

14. Greenfield LJJ, Uhler MK, Macdonald RL. Cyclic GMP-dependent protein kinase II

regulates recombinant GABAA receptor currents in L929 cells. Soc Neurosci Abstr 1994;

20:203.


25

15. Greenfield LJJ, Sutherland ML, Barnard EA, Macdonald RL. A point mutation in the

GABAA receptor subunit confers resistance to barbiturates. Neurology 1995; 45 (4

Suppl.):A360-61.

16. Saxena NC, Neelands TR, Burgard EC, Greenfield LJJ, Macdonald RL. Effects of the

divalent cations, zinc and cadmium, on recombinant GABAA receptors. Soc. Neurosci Abstr

1995; 21:27.

17. Greenfield LJJ, Kume A, Albin RL, Macdonald RL. Felbamate inhibits [3H]t-

butylbicycloorthobenzoate (TBOB) binding and enhances chloride current at the GABAA

receptor. Epilepsia 1995; 36(Suppl. 4):48.

18. Greenfield LJJ, Neelands TR, Zhang J, Turner RS, Macdonald RL. Human teratocarcinoma-

derived neuronal NT2-N cells express functional GABAA receptors and mRNA encoding

GABAA receptor subunits. Soc Neurosci Abstr 1996; 22:1941.

19. Greenfield LJ, Neelands TR, Turner RS, Macdonald RL. Human teratocarcinoma-derived

neuronal NT2-N cells express functional GABAA receptors regulated by convulsant and

anticonvulsant agents. Epilepsia 1996; 37:42.

20. Greenfield LJJ, Turner RS, Macdonald RL. Human clonal NT2-N neurons express voltage-

gated sodium currents sensitive to anticonvulsants. Soc Neurosci Abstr 1997; 23:1477.

21. Greenfield LJJ, Turner RS, Macdonald RL. Carbamazepine and phenytoin regulate voltage-

gated sodium currents in human NT2-N neurons. Epilepsia 1997; 38(Suppl. 8): 45.

22. Neelands TR, Zhang J, Greenfield J, Turner RS, Macdonald RL. GABAA receptors

expressed in human teratocarcinoma NT2 stem cells differ from those expressed by

differentiated neuronal NT2-N cells. Soc Neurosci Abstr 1997; 23:957.

23. Selwa LM, Greenfield LJJ, Fromes G, Drury I, Henry T, Passaro E, Ross D. Distinguishing

features of refractory partial epilepsy patients not offered resection after intracranial

monitoring. Epilepsia 1998; 39(Suppl. 6):83.

24. Greenfield LJJ, Nasreddine W, Kothary S, Beydoun A. Long-term efficacy of new

antiepileptic drugs: Meta-analysis of multiple open label investigative drug trials. Epilepsia

1998; 39(Suppl. 6):60.

25. Hershberg I, Oh PD, Greenfield LJJ, Macdonald RL, Isom LL. Alteration of gating

properties of dimeric type IIA Na+ channels by co-expression of 2 subunits. Soc

Neurosci Abstr 1998; 24:1324.

26. Stetzer A, Nicholls PJ, Greenfield LJ, Macdonald RL, Isom LL. Characterization of voltage-

gated sodium channel localization in NT2 cells. Soc. Neurosci. Abstr. 1998, 25:1731.


26

27. Greenfield LJJ., Selwa LM, Fromes GA, Buchtel HA, Ross DA, Drury IJ, Henry TR.

Presurgical IQ does not predict seizure outcome of temporal lobectomy after intracranial

long-term monitoring. Epilepsia 1999, 40(Suppl.7):212.

28. Greenfield LJJ. Chronic diazepam exposure alters GABAA receptor function in human NT2-

N cells. Soc. Neurosci. Abstr. 2000, 27: 500.9.

29. Greenfield LJJ, Lyons AR, Gao L. Chronic benzodiazepine treatment alters GABAA

receptor subunit expression in human NT2-N cells Soc. Neurosci. Abstr. 2001, 28: 263.12

30. Tietz EI., Van Sickle BJ, Greenfield LJ. NMDA receptor-mediated currents in acutely

dissociated hippocampal CA1 neurons after 1 week benzodiazepine treatment. Soc.

Neurosci. Abstr. 2001, 28: 262.3.

31. Ali II., Greenblatt D, Malik F, Wahl J, Greenfield LJJ. Prevalence of EEG abnormalities in

children with psychiatric disease. Epilepsia 2001, 42(Suppl. 7):24.

32. Ali II, Herial NA, Stojic AS, Koffman B, Greenfield LJ, Pirzada NA. Clinical features of

non-epileptic seizures: A video-EEG study. Epilepsy 2002: 43 (Suppl. 7):39.

33. Tietz EI, Greenfield LJJ, Grounds K, Lyons A , Ferguson C, Homanics GE. Benzodiazepine

(BZ) tolerance studies in GABA-A receptor (GABAR) alpha-1 subunit knock-out mice.

Program No. 39.3. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for

Neuroscience, 2002. Online

34. Pierson RC, Lyons AR, Greenfield LJ. Regulation of NT2-N cell GABAA receptor subunit

expression by steroid hormones. Program No. 739.13. 2002 Abstract Viewer/Itinerary

Planner. Washington, DC: Society for Neuroscience, 2002. Online.

35. Gao L, Lyons AR, Greenfield LJ. Hypoxia-induced changes in GABAA receptor function and

subunit expression in human NT2-N cells. Program No. 433.2. 2002 Abstract

Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2002. Online.

36. Gao L, Lyons AR, Greenfield LJ. Protein Kinase C activation reduces diazepam potency for

enhancing GABAA receptor currents in NT2-N cells. Program No. 47.14. 2003 Abstract


37. Pierson RC, Lyons AR, Greenfield LJ. Regulation of NT2-N cell GABAA receptor subunit

expression by allopregnanolone. Program No. 684.8. 2003 Abstract Viewer/Itinerary

Planner. Washington, DC: Society for Neuroscience, 2003. Online.

38. Gao L, Greenfield LJ. Cobalt induces HIF-1 accumulation and alters GABAA receptor

function and expression in NT2-N neurons. Program No. 47.14. 2003 Abstract



27

39. Luo G, Li Y, Greenfield LJ. Effects of hypoxia on strychine-sensitive glycine receptors in

NT2-N neurons. Program No. 161.3. 2004 Abstract Viewer/Itinerary Planner. Washington,

DC: Society for Neuroscience, 2004. Online.

40. Pierson RC, Greenfield LJ. Allopregnanolone exposure and withdrawal alter GABAA

receptor subunit expression in NT2-N neurons. Program No. 392.8. 2004 Abstract


41. Pierson RC, Greenfield LJ. Allopregnanolone exposure and withdrawal alter GABAA

receptor subunit expression in NT2-N neurons. Epilepsia 2004, 45(Suppl.7): 197.

42. Pierson RC, Fountain A, Greenfield LJ. . Microarray exploration of signaling pathways

involved in regulation of GABAA receptor subunit expression by allopregnanolone

withdrawal. Epilepsia 2005, 46(Suppl.8): 119 (abstract 2.083).

43. Ali II, Herial NA, Pirzada NA, Kaplish N, Greenfield LJ. Non-convulsive status epilepticus

in patients with hypoxic-ischemic encephalopathy: Electroencephalographic features and

outcome. Epilepsia 2005, 46(Suppl.8):131 (abstract 2.120).

44. Gao L, Luo G, Pierson R, Lyons A, Fountain A, Greenfield LJ. Opposite regulation of

GABAA and glycine receptors by hypoxia. Gordon Research Conference: Inihibition in the

CNS. Colby-Sawyer College, July 3-8, 2005.

45. Xiang K, Giovanucci DR, Greenfield LJ, Tietz EI. Enhanced calcium entry through L-type

voltage-gated calcium channels contributes to AMPA receptor plasticity in hippocampal CA1

neurons after chronic benzodiazepine treatment. Program No. 131.12. 2006 Neuroscience

Meeting Planner. Atlanta, GA: Society for Neuroscience, 2006. Online.

46. Das P, Greenfield LJ, Tietz EI. Effects of chronic flurazepam treatment on GABAA receptor

single-channel currents. Program No. 528.12. 2006 Neuroscience Meeting Planner. Atlanta,

GA: Society for Neuroscience, 2006. Online.

47. Pierson RC, Greenfield LJ. Signaling pathways activated by allopregnanolone withdrawal in

NT2-N neurons. Program No. 528.11. 2006 Neuroscience Meeting Planner. Atlanta, GA:

Society for Neuroscience, 2006. Online.

48. Wang L, Gao L, Greenfield LJ. Hypoxia alters GABAA receptor currents in primary cortical

neurons. Program No. 528.10. 2006 Neuroscience Meeting Planner. Atlanta, GA: Society for

Neuroscience, 2006. Online.

49. Boulineau N, Dwyer T, Williford B, Gao L, Luo G, Warner J, Kotchkoski W, Ravindra A,

Greenfield LJ. Differential effects on GABAA receptor function by hypoxic and chemical

stimulation of HIF-1 and calcineurin in NT2-N neurons. Program No. 463.4. 2007

Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2007. Online.


28

50. Wang L, Greenfield LJ. Hypoxia regulates GABAA receptor pharmacology in primary

cortical neurons. Program No. 463.2. 2007 Neuroscience Meeting Planner. San Diego, CA:

Society for Neuroscience, 2007. Online.

51. Greenfield, LJ, Ramesh AK, Burghardt T, Herial N, Cole K, Ali II. Effect of Comorbid

Conditions on Quality of Life in Persons with Epilepsy. Epilepsia 2007, 48 (Suppl.6 ): 106,

Abst. 1.291.

52. Greenfield, LJ, Ramesh AK, Burghardt T, Herial N, Cole K, Ali II. Effect of Comorbid

Conditions on Quality of Life in Persons with Epilepsy. Neurology 2008 70(Suppl. 1): A70.

53. Giovannucci D, Brink C, Pierson R, Tietz EI, Greenfield LJ. .Allopregnanolone and GABA

evoke calcium currents in cortical neurons. Program No. 865.21/MM22. 2008 Neuroscience

Meeting Planner. Washington, DC: Society for Neuroscience, 2008. Online.

54. Greenfield LJ, Xiang K, Tietz EI,. Calcineurin mediates enhanced high-voltage-activated

calcium currents in rat primary cortical neurons after acute hypoxia. Program No. 146.2/W7. 2008 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2008. Online.

55. Wang L, Behrle BL, Greenfield LJ. Post-hypoxic changes in rat cortical neuron GABAA

receptor function require L-type voltage-gated calcium channel activation. Program No. 146.3/W8. 2008 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2008. Online.

56. Boulineau N, Pettee K,. Oyarce AM, Seal R, Tietz EI, Greenfield LJ. Prolonged seizures

affect Hypoxia-Inducible Factor signaling components in vivo. Program No. 146.1/W6. 2008 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2008. Online.

57. Cole K, Herial N, Ramesh AK, Greenfield LJ, Ali II. Screening for folate use in women of

childbearing potential with epilepsy. Neurology 2008 70(Suppl. 1): 36, Prog. 1.081. 58. Das P, Greenfield LJJ, Tietz EI. CaMKII inhibition reverses benzodiazepine-induced

reduction of GABA sensitivity at single GABAA receptor channels. Program No. 531.18/D19. 2008 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2008. Online.

59. Giovannucci D, Brink C, Pierson R, Greenfield LJ. .Allopregnanolone and GABA evoke

calcium currents in cortical neurons. Epilepsia, 2008. 49 (suppl.7):343, Prog. 3.014. 60. Xiang K, Tietz EI, Greenfield LJ. Calcineurin mediates enhanced high-voltage-activated

calcium currents in rat primary cortical neurons after acute hypoxia. Epilepsia, 2008, 49 (suppl.7):336, Prog. IW.73.

61. Wang L, Greenfield LJ. Post-hypoxic changes in rat cortical neuron GABAA receptor

function require L-type voltage-gated calcium channel activation. Epilepsia, 2008. 49 (suppl.7):335, Prog. IW.69.


29

62. Boulineau N, Pettee K, Oyarce AM, Seal R, Tietz EI, Greenfield LJ. Prolonged seizures affect Hypoxia-Inducible Factor signaling components in vivo. Epilepsia, 2008. 49 (suppl.7):339, Prog. 3.004.

63. Zaheer A, Patel B, Herial N, Cole K, Ali II, Ramsey-Williams V, Greenfield Jr. LJ.

Diagnostic Utility of Long Term Epilepsy Monitoring. Epilepsia, 2008. 49 (suppl.7):40, Prog. 1.090.

64. Dwyer, T.A., Behrle, B.L., Greenfield Jr., L.J. Combined hypoxia and hypoglycemia induce

seizures in rats. Program No. 151.5/J4 2010 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience 2010. Online..

65. James, E., Bollineni, A., Ong, A., Li, H., & Greenfield, L. J. (2010). Visual Hallucination and

Charles Bonnet Syndrome. Paper presented at the 17th Annual University of Toledo, Bowling Green State University Symposium on Research.

66. Greenfield, LJ., Shah K, Khubchandani J. Utility of the “Stuffed Animal Sign” and other

circumstantial and behavioral features in the diagnosis of epileptic and non-epileptic seizures. (2011) Neurology 76 (Suppl. 4): A117, P02.102.

67. Greenfield LJ, Ramsey-Williams V, Marshall T, Koffman B. Improved scores on the

American Academy of Neurology Resident Inservice Training Examination (RITE) after lecture curriculum intervention. American Neurological Association, 2011, Poster S404, Annals of Neurology.

68. Cui, L, Behrle BL, M.P.C. Fejleh MPC, He B, He Z, Greenfield, LJJr. Semi-quantitative

detection of intracellular calcium elevation by channelrhodopsin-2 using a microplate fluorescence reader. Program No. 106.02/YY11. 2011 Neuroscience Meeting Planner. Washington DC: Society for Neuroscience 2011. Online.

69. Cui L, Behrle, BL, He B, He Z, Paule MG, Greenfield, Jr LJ. Bio-engineered NT2N cells

express glutamic acid decarboxylases and channelrhodopsin-2. Program No. . 2012 Neuroscience Meeting Planner. Washington DC: Society for Neuroscience 2012. Online.

70. Kozhumyakin M, Behrle B, Cui L, Greenfield Jr. LJ. Hypoxia and hypoglycemia

hypoglycemia suppress GABAergic synaptic transmission via pre- and post-synaptic mechanisms. Program No. . 2012 Neuroscience Meeting Planner. Washington DC: Society for Neuroscience 2012. Online.

71. He Z, Ferguson SA, Cui L, Greenfield, Jr. LJ 2, Paule MG. Stem cell activity may partially

account for postweaning development of the sexually dimorphic nucleus of the preoptic area in rats. Program No. . 2012 Neuroscience Meeting Planner. Washington DC: Society for Neuroscience 2012. Online.

72. Cui L, He Z, He B, Fejleh MPC, Behrle BL, Paule MG, Greenfield Jr LJ. Neuronal death

following transient global ischemia in rats is associated with microvascular PDE4D expression and is delayed in aged animals. 2013 Neuroscience Meeting Planner. Washington DC: Society for Neuroscience 2013. Online.

73. Cui L, Kozhemyakin M, Behrle BL, He B, Fejleh MPC, He Z, Paule MG, Greenfield Jr LJ.


30

Transfected NT2N cells express channelrhodopsin-2 after grafting into organotypic hippocampal slices. 2013 Neuroscience Meeting Planner. Washington DC: Society for Neuroscience 2013. Online.

74. Kozhemyakin M, Cui L, Behrle BL, Greenfield Jr LJ. Electrophysiological properties of channelrhodopsin2 channels differ when expressed in NT2 neurons and HEK293 cells. 2013 Neuroscience Meeting Planner. Washington DC: Society for Neuroscience 2013. Online.

75. Chen YT, Sahaya K, Lee R, Hinkle J, Greenfield, Jr LJ. Eating epilepsy, a rare and under-recognized reflex epilepsy. American Academy of Neurology 2016: Session 32, P1.298

76. Chauhan N, Shukla V, Greenfield Jr., LJ. HSV-2 Transverse Myelitis after Spinal Cord Contusion. American Academy of Neurology 2016: Session 249, P6.347.

77. Benchaya S, Eugene M, Montes-Rivera J, Gregory M, Greenfield LJ. Impact of Driving Restriction on People with Epilepsy (IDRoPS). American Epilepsy Society Annual Meeting, December, 2017. Poster # 3.246.

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