Page | 1

Ewoud van Velzen Curriculum Vitae

1. PERSONAL DETAILS Address

Phone numbers

Email Website

D.O.B.

Oranjelaan 12, 3135 ZN, Vlaardingen, The Netherlands +31(0)104743497 +31(0)610805411 velzene@gmail.com www.velzene.nl 01 June 1968

2. EDUCTION 2007-2010

1991-1994

1987-1991

1981-1986

University of Amsterdam (UvA), Faculty of Science, Amsterdam, The Netherlands PhD in Biosystems Data Analysis Dissertation: "Nutrikinetics" Promotor: Prof. Dr. A.K. Smilde Rijkshogeschool IJselland Polytechnics, Deventer, The Netherlands BSc in Analytical Chemistry Hogeschool Gelderland, Arnhem Intermediate Vocational Education in Analytical Chemistry Combined School Oost-Betuwe, Bemmel Higher General Secondary Education

3. EMPLOYMENT HISTORY 2012-present

2011-2012

2007-2010

2003-2011

Unilever Research and Development, Vlaardingen, The Netherlands Scientist Spectroscopy and Data Modelling. Expertise areas: chemometrics, sensometrics, (quantitative) NMR, hyperspectral image analysis. Unilever Research and Development, Vlaardingen, The Netherlands Assistant manager Spectroscopy and Data Modelling. Expertise areas: chemometrics, (quantitative) NMR, spectroscopic image analysis. University of Amsterdam (UvA), Faculty of Science, Amsterdam, The Netherlands Doctoral Research in Biosystems Data Analysis. Expertise area's: metabolomics, data analysis (multivariate data analysis, multilevel analysis, pharmacokinetics/nutrikinetics, data pre-processing of analytical data). Unilever Research and Development, Vlaardingen, The Netherlands Researcher in Analytical Chemistry (NMR Spectroscopy). Expertise area's: metabolomics, polyphenols, gut metabolism, NMR in foods.

Page | 2

1998-2003

1995-1998

1994-1995

1993-1994

1992-1993

Seasonal employment in 1992 and 1993

1990-1991

Unilever Research and Development, Vlaardingen, The Netherlands Researcher in Analytical Chemistry (Vibrational and Optical Spectroscopy). Expertise area's: mid-infrared spectroscopy (FTIR), near-infrared spectroscopy (NIR), infrared imaging and image analysis (IA), optical spectroscopy (UV-VIS spectroscopy, circular dichroïsm spectroscopy (CD), fluorescence spectroscopy, chemical analysis in foods (including bakery products) and detergents systems (including bleach catalysts). Unilever Research and Development, Vlaardingen, The Netherlands Researcher in Analytical Chemistry (Elemental Analysis). Expertise area's: Graphite Furnace Atomic Absorption Spectroscopy (GF-AAS), Plasma Emission Spectroscopy (PES), X-Ray Fluorescence Spectroscopy (XRF), chemical analysis in foods and detergents systems. Cap Gemini, Utrecht, The Netherlands COBOL software engineer in ING bank, Amsterdam. Project: upgrading monetary transaction software from COBOL/I to COBOL/II programming language. University of Twente, Enschede, The Netherlands Analytical chemist in Chemical Analysis Department. Project: development of a GC-MS based method for determining the age of oil spills in soil. University of Twente, Enschede, The Netherlands NMR trainee in Chemical Analysis Department. BSc traineeship project: NMR conformational studies on calixarenes. Conex B.V., Ede, The Netherlands Analytical chemist in commercial food analysis laboratory Job description: wet chemical analysis of food constituents, e.g. fat (extraction), phosphorus, nitrogen (Kjeldahl), sulphite, and COD. AkzoNobel Research, Deventer, The Netherlands Trainee in Analytical Department. Traineeship project: chromatographic (GC-MS) and wet chemical analysis (thermal titrimetry) of organic peroxides (QC).

4. EXTERNAL COLLABORATIONS 2008-2010

2006-2010

Netherlands Metabolomics Centre NMC is part of the national genomics strategy implemented through the Netherlands Genomics Initiative (NGI) and is its Technology Centre of Excellence for Metabolomics. Participants: (1) Leiden University, (2) University Medical Centre Utrecht, (3) Merck, (4) University of Amsterdam, (5) DSM, (6) TNO, (7) Wageningen University, and (8) Unilever. GUTSYSTEM (EU Research project) Marie Curie Host Fellowship for the Transfer of Knowledge (ToK) Industry-Academia Partnership Scheme (Marie Curie Actions). Participants: (1) L’Institut National de la Recherche Agronomique (INRA, French National Institute for Agricultural Research), France, (2) BioSystems Data Analysis, University of Amsterdam (UvA), The Netherlands, (3) Laboratory of Microbial Ecology and Technology (LabMET), Gent University, Belgium, (4) Unilever Research and Development, The Netherlands.

Page | 3

5. SCIENTIFIC PUBLICATIONS 5.1

5.2

5.3

5.4

5.5

5.6

5.7

5.8

5.9

5.10

5.11

5.12

Janssen, R.G., Verboom, W., Duynhoven van, J.P.M., Velzen van, E.J.J., Reinhoudt, D.N. (1994). Cryptocalix[6]arenes; molecules with a large cavity. Tetrahedron Letters, 35 (35), 6555-6558. Maliepaard, M., Mol de, N.J., Tomasz, M., Gargiulo, D., Janssen, L.H.M., Duynhoven van, J.P.M., Velzen van, E.J.J., Verboom, W., Reinhoudt, D.N. (1997). Mitosene-DNA adducts. Characterization of two major DNA monoadducts formed by 1,10-bis(acetoxy)-7-methoxymitosene upon reductive activation. Biochemistry, 36 (30), 9211-9220. van Velzen, E.J.J., van Duynhoven, J.P.M., Pudney, P., Weegels, P.L., & van der Maas, J.H. (2003). Factors associated with dough stickiness as sensed by attenuated total reflectance infrared spectroscopy. Cereal Chemistry, 80(4), 378-382. van Duynhoven, J. P. M., Haiduc, A., van Dorsten, F., van Velzen, E.J.J. (2007), NMR in foods: The industrial perspective. Royal Society of Chemistry, 310, 1-11. van Duynhoven, J.P.M, van Velzen, E.J.J., Jacobs, D.M., van Dorsten, F.A. (2007). NMR-based Nutritional Metabonomics. GIT Laboratory journal, 11(5-6), 35-37. Grun, C.H., van Dorsten, F.A., Jacobs, D.M., Le Belleguic, M., van Velzen, E.J.J., Bingham, M.O., Janssen, H.G., van Duynhoven, J.P.M. (2008). GC-MS methods for metabolic profiling of microbial fermentation products of dietary polyphenols in human and in vitro intervention studies. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 871(2), 212-219. Jacobs, D.M., Deltimple, N., van Velzen, E.J.J., van Dorsten, F.A., Bingham, M., Vaughan, E.E., van Duynhoven, J. (2008). 1H NMR metabolite profiling of feces as a tool to assess the impact of nutrition on the human microbiome. NMR in Biomedicine, 21(6), 615-626. Westerhuis, J.A., Hoefsloot, H.C.J., Smit, S., Vis, D.J., Smilde, A.K., van Velzen, E.J.J., van Duynhoven, J.P.M., van Dorsten, F.A. (2008). Assessment of PLSDA cross validation. Metabolomics, 4(1), 81-89. Westerhuis, J.A., van Velzen, E.J.J., Hoefsloot, H.C.J., Smilde, A.K. (2008). Discriminant Q2 (DQ2) for improved discrimination in PLSDA models. Metabolomics, 4(4), 293-296. van Velzen, E.J.J., Westerhuis, J.A., van Duynhoven, J.P.M., van Dorsten, F.A., Hoefsloot, H.C.J., Jacobs, D.M., Smit, S., Draijer, R., Kroner, C.I., Smilde, A.K. (2008). Multilevel data analysis of a crossover designed human nutritional intervention study. Journal of Proteome Research, 7(10), 4483-4491. Peters, S., van Velzen, E.J.J., Janssen, H.G. (2009). Parameter selection for peak alignment in chromatographic sample profiling: objective quality indicators and use of control samples. Analytical and Bioanalytical Chemistry, 394(5), 1273-1281. van Duynhoven, J.P.M., van Velzen, E.J.J., Gross, G., van Dorsten, F.A., Jacobs, D.M., Bingham, M., Draijer, R., Mulder, T.P., Koning, M.M.G., Vaughan, E.E., van der Wiele, T., Westerhuis, J.A., Smilde, A.K. (2009). NMR-

Page | 4

5.13

5.14

5.15

5.16

5.17

5.18

5.19

5.20

5.21

5.22

5.23

Based Metabonomics Approaches for the Assessment of the Metabolic Impact of Dietary Polyphenols on Humans. Magnetic Resonance in Food Science: Challenges in A Changing World, Royal Society of Chemistry, 20-28. van Velzen, E.J.J., Westerhuis, J.A., van Duynhoven, J.P.M., van Dorsten, F.A., Grun, C.H., Jacobs, D.M., Duchateau, G.S.M.J., Vis, D.J., & Smilde, A.K. (2009). Phenotyping Tea Consumers by Nutrikinetic Analysis of Polyphenolic End-Metabolites. Journal of Proteome Research, 8(7), 3317-3330. van Velzen, E.J.J., Westerhuis, J.A., Hoefsloot, H.C.J., Smilde, A.K. (2009). Data analysis strategies in nutritional metabolomics. GIT laboratory journal, 13(1-2), 17-19. van Dorsten, F.A., Grun, C.H., van Velzen, E.J.J., Jacobs, D.M., Draijer, R., van Duynhoven, J.P.M. (2010). The metabolic fate of red wine and grape juice polyphenols in humans assessed by metabolomics. Molecular Nutrition & Food Research, 54(7), 897-908. van Velzen, E.J.J. (2010). Nutrikinetics. Thesis. http://dare.uva.nl/dissertaties. Witek, M., Weglarz, W.P., de Jong, L., van Dalen, G., Blonk, J.C.G., Heussen, P., van Velzen, E.J.J., Van As, H., & van Duynhoven, J. (2010). The structural and hydration properties of heat-treated rice studied at multiple length scales. Food Chemistry, 120(4), 1031-1040. Westerhuis, J.A. 1, van Velzen, E.J.J.1, Hoefsloot, H.C.J., Smilde, A.K. (2010). Multivariate paired data analysis: multilevel PLSDA versus OPLSDA. Metabolomics, 6(1), 119-128. 1 Contributed equally to this work. van Duynhoven, J.P.M., Vaughan, E.E., Jacobs, M., Kemperman, A., van Velzen, E.J.J., Gross, G., Roger, L.C., Possemiers, S., Smilde, A.K., Dore, J., Westerhuis, J.A., van de Wiele, T. (2011). Metabolic fate of polyphenols in the human superorganism. Proceedings of the National Academy of Sciences, 108 (Suppl.1), 4531-4538. van Duynhoven, J.P.M., van Velzen, E.J.J., Westerhuis, J.A., Smilde, A.K. (2012). Nutrikinetics: concept, technologies, applications, perspectives. Trends in Food Science and Technology, 26(1), 4-13. Jacobs, D.M., Führmann, J.C., van Dorsten, F.A., Rein, D., Peters, S., van Velzen, E.J.J., Hollebrands, B., Draijer, R., van Duynhoven, J.P.M., Garczarek, U. (2012). Impact of Short-Term Intake of Red Wine and Grape Polyphenol Extract on the Human Metabolome. Journal of Agricultural and Food Chemistry, 60(12), 3078-3085. Szymanska, E., van Dorsten, F.A., Troost, J., Paliukhovich, I., van Velzen, E.J.J., Hendriks, M., Trautwein, E.A., van Duynhoven, J.P.M., Vreeken, R.J., Smilde, A.K. (2012). A lipidomic analysis approach to evaluate the response to cholesterol-lowering food intake. Metabolomics, 8(5), 894-906. Jacobs, D.M., Spiesser, L., Garnier, M., de Roo, N., van Dorsten, F.A., Hollebrands, B., van Velzen, E.J.J., Draijer, R., van Duynhoven, J.P.M. (2012). SPE-NMR metabolite sub-profiling of urine. Analytical and Bioanalytical Chemistry, 404(8), 2349-2361.

Page | 5

5.24

5.25

5.26

5.27

5.28

5.29

5.30

5.31

5.32

5.33

van Duynhoven, J.P.M., van Velzen, E.J.J., Jacobs, D.M. (2013). Quantification of complex mixtures by NMR. Annual Reports on NMR Spectroscopy, 181-236. DOI: 10.1016/B978-0-12-408097-3.00003-2. Jacobs,D.M., van Velzen, E.J.J., Mihaleva,V.(2013). Evaluation of approaches for quantitative targeted profiling of complex compositions using 1D 1H NMR spectroscopy. Proceedings of the 11th International Conference on the Application of Magnetic Resonance in Food Science, Wageningen, June 27-29, 2012. Magnetic Resonance in Food Science; Food for Thought, 3-13. van Velzen, E.J.J., de Roo, N., Poort, R., van Adrichem, L., Brunt, K., Schols, H., Westphal, Y., Mariani, L., Grün, C., van Duynhoven, J.P.M. (2013). Identification and semi-quantification of polysaccharides in complex food matrices by NMR. Proceedings of the 11th International Conference on the Application of Magnetic Resonance in Food Science, Wageningen, June 27-29, 2012. Magnetic Resonance in Food Science; Food for Thought, 156-163. van Duynhoven, J.P.M., van Velzen, E.J.J., Jacobs, D.M. (2013). Quantification of complex mixtures by NMR. Annual Reports on NMR Spectroscopy, 181-236. van Velzen, E.J.J., Westerhuis, J.A., Grün, C.H., van Duynhoven, J.P.M., Jacobs, D.M., Eilers, P.H.C., Mulder, T.P., Foltz, M., Garczarek, U., Kemperman, R. , Vaughan, E.E. Smilde, A.K. (2014). Population based nutrikinetics of dietary polyphenols in humans. Metabolomics, 10, 6, 1059-1073. van Velzen, E.J.J., Dauwan, S., de Roo, N., Grün, C.H., Westphal, Y., van Duynhoven, J.P.M. (2014). Quantitative NMR assessment of polysaccharides in complex food matrices. Magnetic Resonance in Food Science, 39-48. Westerhuis, J.A., van Velzen, E.J.J., Jansen, J.J., Hoefsloot, H.C.J., Smilde, A.K. (2015). Analysis of High-dimensional Data from Designed Metabolomics Studies. Metabolic Profiling: Disease and Xenobiotics, 117-136. Grün, C.H., Sanders, P., van der Burg, M., Schuurbiers, E., van Adrichem, L., van Velzen, E.J.J., de Roo, N., Brunt, K., Westphal, Y., Schols, H.A. (2015). Strategy to identify and quantify polysaccharide gums in gelled food concentrates. Food Chemistry, 166, 42-49. Jacobs, D.M., van Velzen, E.J.J., van Duynhoven, J.P.M., Nutrikinetic assessment of polyphenol exposure (2017). Current Opinion in Food Science, submitted. van Dalen, G., van Velzen, E.J.J., Heussen, P., Sovago, M., van Malssen, K., van Duynhoven, J.P.M. (2017), Raman hyperspectral imaging and analysis of fat spreads, Journal of Raman Spectroscopy, submitted.

6. LECTURES

6.1

6.2

BioRad Usersclub meeting De Hooge Vuursche, Baarn, The Netherlands (March 2, 2000) "FT-IR Spectroscopy at Unilever Research Vlaardingen" 59th Infrared en Raman Discussion Group (IRDG) Day Unilever Research Vlaardingen, The Netherlands (November 16, 2000) "Infrared spectroscopy on textile and detergents"

Page | 6

6.3

6.4

6.5

6.6

6.7

6.8

6.9

6.10

6.11

6.12

6.13

6.14

Four City's Metabolomics Meeting Leiden University, Leiden, The Netherlands (May 25, 2007) "Dietary Polyphenols, Gut Microbes and Human Health" Biological Multivariate Data Analysis (BIO-MVA) Meeting TNO, Zeist, The Netherlands (October 23, 2008) "Bioconversion and nutrikinetics of grape and black tea polyphenols in humans: methodology and biological trends" 5th International Metabolomics Society Conference Crowne Plaza, Edmonton, Alberta, Canada (August 31, 2009) "Nutrikinetics of dietary polyphenols" Annual meeting of the NWO/CW study group Analytical Chemistry and the Dutch Society for Mass Spectrometry (NVMS) De Werelt, Lunteren, The Netherlands (November 3, 2009) "Nutrikinetics of dietary polyphenols" Metabolomics & More Congress HelmHoltz Centre, Munchen, Germany (March 12, 2010) "Nutrikinetics of dietary polyphenols" Netherlands Metabolomics Centre (NMC); Diet-Gut interactions: Effect of Food Formats De Werelt, Lunteren, The Netherlands, (December 6, 2010) "Nutrikinetics of dietary polyphenols" Unilever Exchange Meeting Unilever Research Vlaardingen, The Netherlands (October 24, 2011) “Nutrikinetics of Polyphenols” Swammerdam Institute for Life Sciences (SILS) 1st SILS-Seminar Universiteit van Amsterdam, Amsterdam, The Netherlands (January 12, 2012) “Nutrikinetics” 11th International Conference on the Application of Magnetic Resonance in Food Science Hof van Wageningen, Wageningen, The Netherlands (June 26, 2012) Workshop “Spectral Deconvolution for Metabolite Quantification” 11th International Conference on the Application of Magnetic Resonance in Food Science Hof van Wageningen, Wageningen, The Netherlands (June 29, 2012) “Identification and semi-quantification of polysaccharides in complex food matrices by NMR” Small Molecule NMR conference (SMASH) Hotel Araguaney, Santiago de Compostela, Spain (September 22-25, 2013) “qNMR Targeted Profiling of Food Compounds” 12th International Conference on the Application of Magnetic Resonance in Food Science Teatro Verdi, Cesena, Italy (May 22, 2014) “Quantitative NMR assessment of polysaccharides in complex food matrices”

Page | 7

6.15

6.16

6.17

6.18

6.19

6.20

6.21

MSc COAST Course: Applications of Magnetic Resonance in Food and Nutrition Wageningen University, the Netherlands (June 13, 2015) “Data-analysis: phenotyping based on the urine metabolome” Practical Applications of NMR in Industry (PANIC) San Diego Marriot La Jolla, USA (February 9-12, 2015) “Quantitative NMR assessment of polysaccharides in complex food matrices” Workshop Practical Applications of NMR in Industry (PANIC) San Diego Marriot La Jolla, USA (February 9-12, 2015) “Analytical quality assurance in qNMR” MKS User Meeting Scandic Triangeln, Malmö, Sweden (April 13, 2016) “Predictive modeling and variable selection in food Sensoromics” XVI Chemometrics in Analytical Chemistry (CAC) World Trade Centre, Barcelona, Spain (June 10, 2016) “Robustness: A key parameter in the validation of multivariate sensory regression models” 30th Annual Chemometrics Symposium “Chemometrics in Action” Soeterbeeck, Ravenstein, the Netherlands (October 13, 2016) “Robustness: A key parameter in the validation of multivariate sensory regression models” MSc COAST Course: Applications of Magnetic Resonance in Food and Nutrition Wageningen University, the Netherlands (May 20, 2017) “Data-analysis: phenotyping based on the urine metabolome”

7. PATENTS 7.1 A method for identifying a textile parameter from a soiled textile article

Smit-Kingma, I.E., van Velzen, E.J.J., Warmoeskerken, M.M., US Patent Application No. 2004/0119,972 (June 24, 2004).

8. POSTERS

8.1

8.2

8.3

Intrinsic stability of a Llama antibody fragment as determined by CD, NMR and Mass Spectrometry Perez, J.M.J, Prompers, J.J., Renisio, J.G., van Velzen, E.J.J., ten Haaft, M., Platerink, C., Cambilau, Darbon, H., Frenken, L.G.J. 14th International Conference on Magnetic Resonance in Biological Systems, Florence, Italy (August 20-25, 2000) 1H NMR spectroscopy based fingerprinting of grape extracts van Velzen E.J.J., Draijer, R., van Duynhoven, J.P.M., Frenken, L.G.J. NMR Discussion Group (NMR-DG) Day, Groningen University, The Netherlands (October 24, 2003) Age-associated changes in plasma metabolic profiles as assessed by NMR-based metabonomics van Dorsten, F.A., van Velzen, E.J.J., Post, J.A., Bluyssen, H.R., Braam, B., van Duynhoven, J.P.M.

Page | 8

8.4

8.5

8.6

8.7

8.8

8.9

8.10

EUCHEM conference CHAMPS: CHemometrics Applied to Metabonomics, Proteomics and SAR, Lund, Sweden (September, 2004) NMR-based Metabolomics Analysis of Vascular Endothelial Cells during Stress-Induced Premature Senescence Authors: van Dorsten, F., Koop, I., Regan-Klapisz, E., van Velzen, E.J.J., Post, J.A., van Duynhoven, J.P.M. (I) 1st International Metabolomics Society Conference, Tsuruoka City, Japan (June 20-23, 2005) (II) Small Molecule NMR Conference (SMASH), Verona, Italy (September 25-28, 2005) (III) First Maga Circe Conference on Metabolic Systems Analysis, Sabaudia, Italy (March 26-29, 2006) (IV) NMR Discussion Group (NMR-DG) Day, NV Organon, Oss, The Netherlands (October 13, 2006) Assessment of the metabolic impact of flavonoid intake on humans van Duynhoven, J.P.M., van Velzen, E.J.J., van Dorsten, F.A., Bingham, M., Draijer, R., Daykin, C.A., Mulder, T.P., Kroner, C.I. NMR Discussion Group (NMR-DG) Day, NV Organon, Oss, The Netherlands (October 13, 2006) The metabolic impact of grape/wine intake in humans studied by NMR and GC-MS-based metabolomics van Dorsten, F.A., Grün, C., van Velzen, E.J.J., Draijer, R., van Duynhoven, J.P.M. 3rd International Metabolomics Society Conference, Manchester, UK (June 11-14, 2007) Rapid assessment of grape extract compositions by 1H NMR van Velzen, E.J.J., Klinkenberg, M.F.H., Draijer, R., van Duynhoven, J.P.M. Small Molecule NMR Conference (SMASH), Chamonix, France (July 16-19, 2007) 1H NMR metabolite profiling of faeces as a tool to assess the impact of nutrition on the human microbiome Jacobs, D.M., Deltimple, N., van Velzen, E.J.J., Bingham, M., van Duynhoven, J.P.M. 3rd International Metabolomics Society Conference, Manchester, UK (June 11-14, 2007) Multilevel data analysis of a human nutritional crossover designed study van Velzen, E.J.J., Westerhuis, J.A., van Duynhoven, J.P.M., van Dorsten, F.A., Hoefsloot, H.C.J., Smit, S., Draijer, R., Kroner, C.I., Smilde, A.K. (I) 3rd International Metabolomics Society Conference, Manchester, UK (June 11-14, 2007) (II) SILS Research Day, University of Amsterdam, Faculty of Science, Amsterdam, The Netherlands (June 21, 2007) (III) Meeting of the NWO/CW study group Analytical Chemistry, Lunteren, The Netherlands (November 5-6, 2007) (IV) 11th Conference on Chemometrics in Analytical Chemistry, Montpellier, France (June 30 - July 4, 2008) Pharmaco-metabolomics investigation of black tea metabolization van Velzen, E.J.J., Westerhuis, J.A., van Duynhoven, J.P.M., van Dorsten, F.A., Grün, C., Jacobs, D.M., Duchateau, G.S.M.J.E., Mulder, T.P., Vis, D.J., Draijer, R., Koning, M.M.G., Smilde, A.K.

Page | 9

8.11

8.12

8.13

8.14

8.15

8.16

8.17

8.18

Metabomeeting, Ecole Normale Supérieure de Lyon, Lyon, France (April 28-29, 2008) Parameter selection for peak alignment in chromatographic sample profiling: objective quality indicators and use of control samples Peters, S., van Velzen, E.J.J., Janssen, H.G. Meeting of the NWO/CW study group Analytical Chemistry, Lunteren, The Netherlands (November 3-4, 2008) Pharmacokinetics and metabolism of tea flavonoids after ingestion of black tea by humans Grün, C., Hollebrands, B., van Velzen, E.J.J., van Dorsten, F.A., Mulder, T.P., Janssen, H.G. Meeting of the Netherlands and Belgium Societies for Mass Spectroscopy (NVMS-BSMS), Rolduc, Kerkrade, The Netherlands (March 26-27, 2009) Diet-Gut interactions: effects of food formats van Duynhoven, J.P.M., Jacobs, D.M., van Velzen, E.J.J., van Tilborg, M., Bendik, I., Hall, R., de Vos, R., Smilde, A.K., Westerhuis, J.A. Kick-off meeting Netherlands Metabolomics Centre (NMC), Zeist, The Netherlands (February 5-6, 2009) An NMR and GC-MS Metabolomics approach to determine the metabolic fate of red wine and grape juice polyphenols in humans van Dorsten, F.A., Grün, C., van Velzen, E.J.J., Jacobs, D.M., Draijer, R., van Duynhoven, J.P.M. Metabomeeting, NBI Conference Centre, Norwich, UK (July 5-8, 2009) Nutrikinetics of polyphenol metabolites in humans after consuming black tea and red grapes van Velzen, E.J.J., Westerhuis, J.A., van Duynhoven, J.P.M., van Dorsten, F.A., Grün, C., Jacobs, D.M., Duchateau, G.S.M.J.E., Mulder, T.P., Smilde, A.K (I) Metabomeeting, NBI Conference Centre, Norwich, UK (July 5-8, 2009) (II) 5th International Metabolomics Society Conference, Edmonton, Alberta, Canada (August 31, 2009) NMR-based nutrikinetic approach for the assessment of inter-individual variation in the bioconversion of dietary polyphenols in humans van Duynhoven, J.P.M., van Velzen, E.J.J., van Dorsten, F.A., Kemperman, R., Vaughan, E.E., Smilde, A.K., Jacobs, D.M., Westerhuis, J.A. Small Molecule NMR Conference (SMASH), Chamonix, France (September 20-23, 2009) Plasma kinetics of selected black tea and grape juice/red polyphenols are not source-depended in humans van Velzen, E.J.J., Westerhuis, J.A., van Duynhoven, Mulder, T.P., Grün, C., F.A., Foltz, M., Smilde, A.K. 4th International Conference on Polyphenols and Health (ICPH), Leeds, UK (December 7-11, 2009) Difference in metabolic phenotype and urinary kinetics of flavonoid metabolites in humans after a black tea and grape juice/red wine intervention van Velzen, E.J.J., Westerhuis, J.A., van Duynhoven, J.P.M., Jacobs, D.M., van Dorsten, F.A., Foltz, M., Smilde, A.K. 4th International Conference on Polyphenols and Health (ICPH), Leeds, UK (December 7-11, 2009)

Page | 10

8.19

8.20

8.21

8.22

8.23

8.24

8.25

8.26

Impact of short-term intake of wine and grape polyphenols on human metabolism Jacobs, D.M., Führmann, J.C., Rein, D., van Dorsten, F.A., van Velzen, E.J.J., Draijer, R., van Duynhoven, J.P.M., Garczarek, U. 6th International Metabolomics Society Conference, Amsterdam, The Netherlands (June 28 - July 1, 2010) Gut metagenomic library screening for identification of polyphenol bioconversion activity Roger, L., Kemperman, R., Philippe, C., Leclerc, M., van Velzen, E.J.J., Vaughan, E.E., Doré, J. Research Prize innovation fair, Unilever Research and Development, Vlaardingen, The Netherlands (November 23, 2010) Dietary polyphenols, gut microbes and human health: a systems biology approach Kemperman, R., van Velzen, E.J.J., Roger, L., van Dorsten, F.A., Gross, G., Vaughan, E.E., van Duynhoven, J.P.M., Jacobs, D.M. Research Prize innovation fair, Unilever Research and Development, Vlaardingen, The Netherlands (November 23, 2010) Nutrikinetics of dietary polyphenols in humans using mixed-effects models van Velzen, E.J.J., Westerhuis, J.A., van Duynhoven, J.P.M., Grün, C., Jacobs, D.M., van Dorsten, F.A., Foltz, M., Smilde, A.K. (I) Chemometrics symposium, Utrecht, The Netherlands (May 20, 2010) (II) Internal meeting Netherlands Metabolomics Centre (NMC), Lunteren, The Netherlands (December 6-7, 2010) Examples of experimental design in time-resolved metabolomics studies Smit, S., Zwanenburg, G., Reijmers, T.H., Westerhuis, J.A., Zha Ying, Punt P.J., van Velzen, E.J.J., van Duynhoven, J.P.M., de Graaf, A.A., Smilde, A.K. Netherlands Metabolomics Centre (NMC) Meeting, Lunteren, The Netherlands (May 30-31, 2011) QNMR in food systems van Velzen, E.J.J., de Roo, N., van Geffen, P., Hoos, P.B., van Dorsten, F.A., van Duynhoven, J.P.M. (I) Small Molecule NMR conference (SMASH), Chamonix, France (September 18-21, 2011) (II) NMR Discussion Group (NMR-DG) Day, DSM Delft/The Hague, The Netherlands (October 28, 2011) (III) 11th International Conference on the Application of Magnetic Resonance in Food Science, Wageningen, The Netherlands (June 29, 2012) Identification and semi-quantification of polysaccharides in complex food matrices by NMR van Velzen, E.J.J., de Roo, N., Mariani, L., Poort, R., van Adrichem, L., Brunt, K., Schols, H.A., Westphal, Y., Grun, C.H., van Duynhoven, J.P.M. 11th International Conference on the Application of Magnetic Resonance in Food Science, Wageningen, The Netherlands (June 29, 2012) QNMR Targeted Profiling of Food Compounds van Velzen, E.J.J., de Roo, N., van Dorsten, F.A., Devys, C., Mariani, L., Hoos, P.B., van Duynhoven, J.P.M. (I) Small Molecule NMR conference (SMASH), Santiago de Compostela, Spain (September 22-25, 2013) (II) 48th NMRDG meeting, Eindhoven, the Netherlands (November 8, 2013)

Page | 11

8.27

8.28

8.29

8.30

QNMR Approaches for Polar Low Molecular Weight Compounds in Complex Food Samples, a Case Study de Roo, N., van Velzen, E.J.J., Mihaleva, V., Mariani, L., van Duynhoven, J.P.M., van Dorsten, F.A., Hoos, P.B. (I) Small Molecule NMR conference (SMASH), Santiago de Compostela, Spain (September 22-25, 2013) (II) 48th NMRDG meeting, Eindhoven, the Netherlands (November 8, 2013) Molecular localization of lipids in emulsions using Vibrational Micro-Spectroscopy Sovago, M., Voda, A., van Velzen, E.J.J., Heussen, P.C.M., van Duynhoven, J.P.M. (I) XXIV International conference on Raman Spectroscopy (ICORS), Jena, Germany (August 10-15, 2014) (II) Focus on Microscopy, Göttingen, Germany (March 29- April 1, 2015) Quantitative assessment of polysaccharide mixtures by NMR Merkx, D., van Velzen, E.J.J., Dauwan, S., Westphall, Y., van Duynhoven, J.P.M. 49th NMRDG meeting, Oss, the Netherlands (October 31, 2014) Raman hyperspectral imaging and analysis of food emulsions van Dalen, G., van Velzen, E.J.J., Heussen, P.C.M., Sovago, M., van Malssen K.F., van Duynhoven, J.P.M. 6th Conference in spectral imaging, IASIM, Chamonix, France (July 3-6, 2016)

9. AWARDS

9.1

9.2

9.3

9.4

9.5

Winner poster prize ICPH 2009 Conferred at: 4th International Conference on Polyphenols and Health (ICPH), Leeds, UK (December 7-11, 2009) Title: Difference in metabolic phenotype and urinary kinetics of flavonoid metabolites in humans after a black tea and grape juice/red wine intervention van Velzen, E.J.J., Westerhuis, J.A., van Duynhoven, J.P.M., Jacobs, D.M., van Dorsten, F.A., Foltz, M., Smilde, A.K. Winner URDV Team Award 2011 Conferred by: Unilever Research and Development, Vlaardingen, The Netherlands (October 6, 2011) Winner of the Team Award 2011 in the category Outstanding Contributions. Winner I.M. Kolthoffprijs 2011 Conferred by: Royal Dutch Society of Chemistry (KNCV) and Section Analytical Chemistry (SAC) (October 13, 2011) Award for outstanding scientific research in the field of analytical chemistry (PhD thesis). Winner Best Paper Award Pre-2013 Metabolomics Society’s Publication Awards 2013 Westerhuis, J.A., Hoefsloot, H.C.J., Smit, S., Vis, D.J., Smilde, A.K., van Velzen, E.J.J., van Duynhoven, J.P.M., van Dorsten, F.A., Assessment of PLSDA cross validation, DOI: 10.1007/s11306-007-0099-6 Winner Highest Download Award 2013 Metabolomics Society’s Publication Awards 2013

Page | 12

9.6

Westerhuis, J.A., van Velzen, E.J.J., Hoefsloot, H.C.J., Smilde, A.K., Multivariate paired data analysis: multilevel PLSDA versus OPLSDA, DOI: 10.1007/s11306-009-0185-z Winner VOPAK Sportstimuleringsprijs (non-professional) TOG table tennis Masterclass 2013-2014 van Velzen, E.J.J., Hendriks, J., Breevaart, D. Maassluis sportgala (Februari 14, 2014)

10. EXTRACURRICULAR ACTIVITIES

1979-Present

1991-1993

2004-2006

2010-Present

2011-Present

2014-Present

Table tennis player Played at the national level: level C (juniors) and 3rd division (adults) Table tennis trainer/coach Torenstad Zutphen, juniors. Table tennis trainer TOG Maassluis, adults. Table tennis trainer/coach TOG Maassluis, juniors. Alexandria’66 Rotterdam, juniors. Board Membership General Junior Activities Table Tennis club TOG Maassluis. Board Membership tournament commission Nederlandse Tafeltennis Bond (NTTB) district West