Topiccurrent updates on protein protein interactions

presented by Ifrah IshaqUniversity of the punjab,lahore

Define protein protein interactions?The specific physical contacts established between two or more proteins as a result of biochemical events and electrostatic forces.Proteins associate physically to create macromolecular structures of various complexities and heterogeneities.

Importance Of PPIs

Signal TransductionTransport Across MembranesCell MetabolismMuscle Contraction

Types Of PPIsFollowing types of PPIs:

Homo-oligomers Vs. Hetero-oligomers

Stable Interactions Vs. Transient Interactions

Covalent Vs. Non-covalent

Methods to PPIsThere are following methods to detect PPIs:

Two Hybrid System

Affinity Chromatography

Co Immunoprecipitations

Two hybrid system

Affinity Chromatography

Co Immunoprecipitations

Current updates on PPIs

Protein-DNA Interaction Disruptions Protein Misfolding New Undesired Protein Interactions Pathogen-host Protein Interactions 

Discovery Of A Gene's Biological Function Schizophrenia 1 Huntington’s disease

PPIs used to explore the differences between healthy and diseased states

Protein–protein Interaction As Therapeutic Targets

PPI as putative therapeutic targets for the development of new treatments is particularly evident in cancer, with several ongoing clinical trials within this area. The consensus among these promising targets is, nonetheless, denoted in the already available drugs on the market to treat a multitude of diseases.

WORK IN PAKISTAN

Center Of Excellence Molecular Biology University Of Agriculture, Faisalabad University Of Karachi Quaid-e-Azam University, Islamabad

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