crystallization & solid state - rise - research institutes ... · crystallization & solid...
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Crystallization & Solid State
Your Solid – from Calculations to Process
Solid State Investigations Crystallization Development Crystallization Scale-Up
In-Silico Studies Analysis of Solid Materials Troubleshooting
Pycnometry, Tap Density
Gas Adsorption
Bulk Properties
Particle Size Distribution
Porosity
Specific Surface Area
Crystal Habit
Density & Bulk Density
Dissolution Rate
Hydrofilicity & Hydrophobicity
Gravimetric Vapour Sorption
Bulk Property Calculations
Scanning Electron Microscopy, Light Microscopy
Sieving, Laser Diffraction
Gas Adsorption
SXRD*
PLM*
Calorimetry, DSC*, TGA,* Hot-Stage PLM*
GVS*
XRPD*, FTIR*, FT-Raman
Crystal Structure Determination
Structure Informatics
Crystal Growth
Solubility & Phase Diagrams
Solid Form Screening
Chirality
Optical Properties
PROTEUS*
Salts, Co-Crystals, Polymorphs, Solvates
Crystallization Design & Scale-Up
Molecular Properties
Solid Phase Identity
Solid - Solvent Interactions
Thermal Properties
Crystallinity & Amorphicity
PLM*, XRPD*, GVS*, Calorimetry
Eidothea*
DSC = Differential Scanning Calorimetry, Eidothea = Automated Solubility = f(temperature), GVS = Gravimetric Vapour Sorption, PLM = Polarized Light Microscopy, PROTEUS = Automated Crystallization Screening Robot, SXRD = Single Crystal X-ray Diffraction, TGA = Thermogravimetric Analysis, XRPD = Powder X-Ray Diffraction.