cronic hepatitis, cirrhosis, hepatic failure assoc. prof. dr. ingrid miron
TRANSCRIPT
![Page 1: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/1.jpg)
CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE
ASSOC. PROF. DR. INGRID MIRON
![Page 2: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/2.jpg)
What is Viral Hepatitis ?
• Viral hepatitis is a systemic disease with primary inflammation of the liver by any one of a heterogenous group of hepatotropic viruses
2
![Page 3: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/3.jpg)
Hepatitis Terms
• Acute Hepatitis: Short-term hepatitis.– Body’s immune system clears the virus from
the body within 6 months• Chronic Hepatitis: Long-term hepatitis.
– Infection lasts longer than 6 months because the body’s immune system cannot clear the virus from the body
![Page 4: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/4.jpg)
HEPATITIS VIRUSES
• Hepatitis A (HAV) Picornaviridae (1973)
• Hepatitis B (HBV) Hepadnaviridae (1970)
• Hepatitis C (HCV) Flaviviridae (1988)
• Hepatitis D (HDV) ? (1977)
• Hepatitis E (HEV) (Caliciviridae) (1983), Hepeviridae
• Hepatitis F – Not separate entity – Mutant of B Virus.
• Hepatitis G (HGV) Flaviviridae (1995)
4
![Page 5: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/5.jpg)
Viral Hepatitis - Historical Perspectives
“Infectious”
5
A
Viral hepatitis NA:NB
EEntericallytransmitted
“Serum” B D CParenterallytransmitted
F- MutantOf B
G
![Page 6: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/6.jpg)
Type of Hepatitis
A B C D E
Source ofvirus
Feces BloodBlood derived
Body fluids
BloodBlood derived
Body fluids
BloodBlood derived
Body fluids
Feces
Route ofTransmission
Feco-oral PercutaneousPermucosal
PercutaneousPermucosal
PercutaneousPermucosal
Feco-oral
ChronicInfection
No Yes Yes Yes No
Prevention Pre PostExposure
Immunization
Pre PostExposure
ImmunizationBlood donor
screening
Blood donor screening
Pre PostExposure
Immunization
EnsureSafe
Drinkingwater
6
![Page 7: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/7.jpg)
7
Hepatitis B Virus
![Page 8: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/8.jpg)
4、 Epidemiology
• 350,000,000 carriers worldwide
• 120,000,000 carriers in China
- the carrier rate can exceed 10%
-15 to 25% of chronically infected patients will die from chronic liver disease
• 500,000 deaths/year in China
• 50% of children born from mothers with chronic HBV in the US are Asian American
8
![Page 9: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/9.jpg)
Geographic Distribution of Chronic HBV Infection
HBsAg Prevalence
8% - High
2-7% - Intermediate
<2% - Low
![Page 10: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/10.jpg)
Whom to screen • Patients with elevated liver enzymes • Patients with HCC, Cirrhosis ,liver fibrosis• Immigrants from areas of high HBV prevalence• Families , household members and sexual contacts of HBV +
person• Patients in psychiatric institutions, residents of welfare
institutions and mentally disabled • Homo/Bisexuals and person having multiple sexual partners • Active and ex drug user • Dialysis patients
![Page 11: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/11.jpg)
11
Parenteral - IV drug abusers, health workers are at increased risk.
Sexual - sex workers and homosexuals are particular at risk.
Perinatal (Vertical) –mother (HBeAg+)→infant.
HBV: Modes of Transmission
![Page 12: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/12.jpg)
Properties of HBV
• a member of the hepadnavirus group• Circular partially double-stranded DNA viruses • Replication involves a reverse transcriptase.
12
![Page 13: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/13.jpg)
HBV : Structure
• Virion also referred to as Dane particle (d-stranded DNA) • 42nm enveloped virus • Core antigens located in the center (nucleocapsid)
* Core antigen (HBcAg) * e antigen (HBeAg)- an indicator of transmissibility (minor
component of the core- antigenically distinct from HBcAg) • 22nm spheres and filaments other forms- no DNA in these
forms so they are not infectious (composed of surface antigen)- these forms outnumber the actual virions
13
![Page 14: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/14.jpg)
HBV Structure & Antigens
14
Dane particle
HBsAg = surface (coat) protein ( 4 phenotypes : adw, adr, ayw and ayr)
HBcAg = inner core protein (a single serotype)
HBeAg = secreted protein; function unknown
![Page 15: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/15.jpg)
Serology
• Antigen Detection- HBsAg,HBcAg,HBeAg• Antibody Detection-Anti HBc, Anti-HBe, Anti-
HBs• DNA Detection- HBV DNA
![Page 16: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/16.jpg)
Diagnosis
![Page 17: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/17.jpg)
Clinical FeaturesIncubation period: Average 60-90 days Range 45-180 daysInsidious onset of symptoms. Tends to cause a more severe disease than Hepatitis A.Clinical illness (jaundice): <5 yrs, <10%
≥ 5 yrs, 30%-50% 1/3 adults-no symptomsClinical Illness at presentation 10 - 15%
Acute case-fatality rate: 0.5%-1% Chronic infection: < 5 yrs, 30%-90%
≥ 5 yrs, 2%-10%
More likely in asymptomatic infections Premature mortality from
chronic liver disease: 15%-25%
![Page 18: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/18.jpg)
Hepatitis B-Signs and Symptoms
– Nausea– Loss of appetite– Vomiting– Fatigue– Fever
– Dark urine– Pale stool– Jaundice– Stomach pain– Side pain– Itchy skin– Hepatitis B virus has
been linked to the development of Membranous glomerulonephritis (MGN).
![Page 19: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/19.jpg)
Diagnosis• A battery of serological tests are used for the diagnosis of
acute and chronic hepatitis B infection.• HBsAg - used as a general marker of infection.• HBsAb - used to document recovery and/or immunity to
HBV infection. • anti-HBc IgM - marker of acute infection.• anti-HBcIgG - past or chronic infection.• HBeAg - indicates active replication of virus and therefore
infectiveness.• Anti-Hbe - virus no longer replicating. However, the
patient can still be positive for HBsAg which is made by integrated HBV.
• HBV-DNA - indicates active replication of virus, more accurate than HBeAg especially in cases of escape mutants. Used mainly for monitoring response to therapy.
![Page 20: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/20.jpg)
HBsAg negative
antiHBc negative susceptible
antiHBs negative
HBsAg negativeantiHBc positive immune due to natural infectionantiHBs positive
HBsAg negativeantiHBc negative immune due to vaccineantiHBs positive
HBsAg positiveantiHBc ( total ) positive acutely infectedIgM antiHBc positiveantiHBs negative
HBsAg positiveantiHBc ( IgG) positive chronicallyIgM antiHBc negative infectedantiHBs negativeHBsAg negativeantiHBc ( IgG) positiveantiHBs negative
Interpretation of Hepatitis B Panel
1.resolution of chronic infection2. “window period” infection3. false-positive anti-HBc4. active infection with waning HBsAg
![Page 21: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/21.jpg)
Differential diagnosis• - Acute icteric hepatitis
– The jaundice caused by another disease• Hemolytic jaundice • Extrahepatic obstructive jaundice
– Hepatitis caused by another reasons • Toxic hepatitis • Infective toxic hepatitis • Mononucleosis • Alcohol hepatic disease • Schistosomiosis • Wilson disease
![Page 22: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/22.jpg)
Phases of Chronic HBV Infection
![Page 23: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/23.jpg)
Immune tolerant
• HBsAg and HBeAg detectable • Biopsy not generally indicated• HBV DNA >20,000 IU/mL (>105 copies/mL) • Antiviral therapies are generally ineffective• ALT normal Risk of drug resistance if treated with
nucleos(t)ide analogs• Absent or minimal liver inflammation and fibrosis • Continued monitoring recommended
![Page 24: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/24.jpg)
HBeAg+ immune active
• HBsAg and HBeAg remain detectable Most children still show no signs or symptoms of disease
• HBV DNA >20,000 IU/mL (>105 copies/mL) Biopsy indicated
• ALT persistently elevated: Appropriate testing should be considered to rule out other liver diseases
• Liver inflammation and fibrosis can develop Treatment should be considered
![Page 25: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/25.jpg)
Inactive HBsAg ‘‘carrier’’
• HBsAg present • Age at seroconversion appears to be influenced by HBV
genotype• HBeAg undetectable, anti-HBe present . Risk of
developing cirrhosis declines• HBV DNA <2000 IU/mL (<104 copies/mL)• or undetectable . Risk of developing HCC• ALT normal . Biopsy generally not indicated• Absent or minimal liver inflammation, fibrosis will
regress over time. Continued monitoring recommended
![Page 26: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/26.jpg)
Reactivation or HBeAg-negativeimmune active
• HBsAg present occurs in 20-30% of patients• HBeAg remains negative and anti-HBe positive Called ‘‘e-
antigen-negative’’ hepatitis B• HBV DNA levels >2000 IU/mL (>104 copies/mL) Usually
due to basal core promoter or precore mutation• ALT normal or elevated Liver biopsy indicated, especially if
ALT abnormal• Active liver inflammation and fibrosis :Treatment should be
considered if moderate or severe inflammation or fibrosis present.Treatment with nucleos(t)ide analogs may be long-term
![Page 27: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/27.jpg)
Possible Outcomes of HBV Infection
Acute hepatitis B infection
Chronic HBV infection
3-5% of adult-acquired infections
95% of infant-acquired infections
Cirrhosis
Chronic hepatitis
12-25% in 5 years
Liver failure Hepatocellular carcinoma
Liver transplant
6-15% in 5 years 20-23% in 5 years
DeathDeath
![Page 28: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/28.jpg)
A liver biopsy is indicated in the following scenarios:
• HBeAg-negative and HBV DNA ≥ 20,000 IU/ml and ALT < 2x ULN
• HBeAg-negative and HBV DNA = 2,000–19,999 IU/ml
• HBeAg-positive and HBV DNA ≥ 20,000 IU/ml and ALT < 2x ULN and age ≥ 40
![Page 29: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/29.jpg)
Treatment
![Page 30: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/30.jpg)
Goals of HBV Therapy
• HBV infection cannot eliminated or “cured” • The clinical goal of HBV treatment (primary
goal )Prevention or reversal of complications
/deaths suppress HBV replication and achieve a target
HBV DNA <10-15 IU/mL Can allow biochemical remission and prevent further
liver injury
![Page 31: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/31.jpg)
Goals of HBV Therapy
In HBeAg-positive patients (cont)HBeAg loss and seroconversion
In HBeAg-positive and HBeAg-negative patients HBsAg loss and seroconversion is ultimate form of
HBV treatment success Best predictor of durable viral suppression Strongest indicator of best longterm outcome, lowest risk
of cirrhosis and liver cancerNot achieved by the majority of patients
Histological Improvement
![Page 32: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/32.jpg)
Options in treatment
![Page 33: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/33.jpg)
Interferon alfa-2b
Lamivudine
Adefovir
Peginterferon alfa-2a
Telbivudine
Tenofovir
1990 1998 2002 2005 2006 2008
Entecavir
1990 1998 2002 2005 2006 2008
Evolution of Approved HBV Therapy Over Time
![Page 34: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/34.jpg)
Treatment• Interferon - for HBeAg +ve carriers with chronic active hepatitis.
Response rate is 30 to 40%.– alpha-interferon 2b (original)– alpha-interferon 2a (newer, claims to be more efficacious
and efficient)• Lamivudine - a nucleoside analogue reverse transcriptase
inhibitor. Well tolerated, most patients will respond favorably. However, tendency to relapse on cessation of treatment. Another problem is the rapid emergence of drug resistance.
• Adefovir – less likely to develop resistance than Lamivudine and may be used to treat Lamivudine resistance HBV. However more expensive and toxic
• Entecavir – most powerful antiviral known, similar to Adefovir• Successful response to treatment will result in the
disappearance of HBsAg, HBV-DNA, and seroconversion to HBeAg.
![Page 35: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/35.jpg)
• Interferon-Alfa• IFN-alfa-2b has been used for the treatment of chronic HBV infection
in children for more than a decade.
• Lamivudine is now considered first-line therapy. Lamivudine is labeled for treatment of chronic HBV infection in children of age 3 and older. Discontinue lamivudine only when repeated assays demonstrate HBeAg loss or seroconversion to HBeAb
• Adefovir Dipivoxil. Adefovir is labeled for use in children age 12 years and older, and is the preferred oral treatment option for children ages 12-15
• Entecavir and Tenofovir - adolescent
![Page 36: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/36.jpg)
Prevention• Vaccination - highly effective recombinant vaccines are now
available. Vaccine can be given to those who are at increased risk of HBV infection such as health care workers. It is also given routinely to neonates as universal vaccination in many countries.
• Hepatitis B Immunoglobulin - HBIG may be used to protect persons who are exposed to hepatitis B. It is particular efficacious within 48 hours of the incident. It may also be given to neonates who are at increased risk of contracting hepatitis B i.e. whose mothers are HBsAg and HBeAg positive.
• Other measures - screening of blood donors, blood and body fluid precautions.
![Page 37: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/37.jpg)
Hepatitis B Vaccine
• Infants: several options that depend on status of the mother – If mother HBsAg negative: birth, 1-2m,6-18m – If mother HBsAg positive: vaccine and Hep B immune
globulin within 12 hours of birth, 1-2m, <6m • Adults * 0,1, 6 months • Vaccine recommended in
– All those aged 0-18 – Those at high risk
37
![Page 38: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/38.jpg)
AASLD 2007[1] US Algorithm 2008[2] EASL 2009[3]
HBV DNA, IU/mL > 20,000 > 20,000 ≥ 2,000
ALT, x ULN* > 2 > 1 > 1
Disease stage/gradeModerate/severe necroinflammation
and/or significant fibrosis
First-line therapyADV,† ETV,
pegIFN ETV, TDF,
pegIFNETV, TDF,
pegIFN
Criteria for HBV DNA, ALT and disease stage/grade must all be met
– If not, guidelines recommend monitoring and consideration of treatment based on individual’s age, health status, and stage of infection/disease
1. Lok A, et al. Hepatology. 2007;45:507-539. 2. Keeffe EB, et al. Clin Gastroenterol Hepatol. 2008;6:1315-1341. 3. EASL HBV Guidelines. J Hepatology. 2009;50:227-242.
Recommendations for Treatment Initiation in HBeAg-Positive Patients
![Page 39: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/39.jpg)
AASLD 2007[1] US Algorithm 2008[2] EASL 2009[3]
HBV DNA, IU/mL > 20,000‡ > 2000 ≥ 2000
ALT, x ULN* 1 to > 2 > 1 > 1
Disease stage/gradeModerate/severe necroinflammation
and/or significant fibrosis
First-line therapyADV,† ETV,
pegIFN ETV, TDF,
pegIFNETV, TDF,
pegIFN
Criteria for HBV DNA, ALT and disease stage/grade must all be met
– If not, guidelines recommend monitoring and consideration of treatment based on individual’s age, health status, and stage of infection/disease
1. Lok A, et al. Hepatology. 2007;45:507-539. 2. Keeffe EB, et al. Clin Gastroenterol Hepatol. 2008;6:1315-1341. 3. EASL HBV Guidelines. Journal of Hepatology. 2009;50:227-242.
Recommendations for Treatment Initiation in HBeAg-Negative Patients
![Page 40: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/40.jpg)
Selecting an Interferon-Based Initial HBV Treatment
![Page 41: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/41.jpg)
Factors Associated With Choosing Interferon for Initial Therapy
Favorable predictors of responseGenotype A or B > C or D
Low HBV DNA (baseline and on treatment)
High ALT (baseline)
Specific patient demographicsYounger people
Young woman wanting future pregnancyPatient preference
No coinfection with HIV
Concomitant HCV infection
![Page 42: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/42.jpg)
Months
Depression
Fatigue
Flu-like symptoms
Anxiety
1 2 3 40
Incr
ease
in
Inci
denc
e/Se
verit
y
Keeffe EB, et al. Clin Gastroenterol Hepatol. 2008;6:1315-1341.
Patients should be carefully monitored for adverse eventsMost common adverse events: flu-like symptoms (fever, chills, headache,
malaise, and myalgia) as well as psychological impairment
PegIFN Treatment-Associated Adverse Effects
![Page 43: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/43.jpg)
On interferon alpha therapy:
• Primary non-response is defined as • less than 1 log10 IU/ml decrease in HBV DNA level from• baseline at 3 months of therapy.
• Virological response is defined as an HBV DNAconcentration of less than 2000 IU/ml at 24 weeksof therapy.
• Serological response is defined by HBe seroconversionin patients with HBeAg-positive CHB.
![Page 44: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/44.jpg)
![Page 45: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/45.jpg)
Monitor HBV patients who are not in treatment
• HBeAg(+) and treatment not indicated:
• ALT every 3–6 months if WNL; ALT every 1–3 months if 1–2x ULN.• HBV DNA viral load every 6–12 months.• Liver biopsy if ALT ≥ 2x ULN for 6 months, or if ALT 1–2x ULN for 6
months and age ≥ 40
• HBeAg(–) and treatment not indicated:
• ALT every 3 months for 1 year; then every 6–12 months.• HBV DNA viral load if ALT > 1–2x ULN.• Liver biopsy if persistent ALT elevation or HBV DNA ≥ 2,000 IU/ml.
![Page 46: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/46.jpg)
.
Monitoring schedule for Nucleos(t)ide Analogues:
ALT and AST levels every 3–6 months
HBeAg every 3–6 months (in patients who are HBeAg(+) at start of treatment)
HBsAg every 6–12 months (in patients who are HBeAg(–) at start of treatment)
HBV DNA viral load every 3 months during first year of therapy; then every 6 months
Serum creatinine every 12 weeks while taking adefovir or tenofovir
Monitoring schedule for Interferon alfa:
Monitor patients on treatment
![Page 47: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/47.jpg)
Monitor patients on treatment• Monitoring schedule for Nucleos(t)ide Analogues:• ALT and AST levels every 3–6 months
• HBeAg every 3–6 months (in patients who are HBeAg(+) at start of treatment)
• HBsAg every 6–12 months (in patients who are HBeAg(–) at start of treatment)
• HBV DNA viral load every 3 months during first year of therapy; then every 6 months
• Serum creatinine every 12 weeks while taking adefovir or tenofovir
• Monitoring schedule for Interferon alfa:
![Page 48: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/48.jpg)
Hepatitis C
![Page 49: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/49.jpg)
HEPATITIS C VIRION: spherical, icosahedral,NUCLEIC ACID: ss (+) RNA
![Page 50: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/50.jpg)
hypervariableregion
capsid envelopeprotein
protease/ helicase RNA-dependentRNA polymerase
c22
5’
core
E1 E2 NS2
NS3
33c
NS4
c-100
NS5
3’
Hepatitis C Virus
![Page 51: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/51.jpg)
Hepatitis C VirusGenome resembled that of a flavivirus
positive stranded RNA genome of around 10,000 bases1 single reading frame, structural genes at the 5' end, the non-
structural genes at the 3' end. enveloped virus, virion thought to 30-60nm in diameter
morphological structure remains unknownHCV has been classified into a total of six genotypes (type 1
to 6) on the basis of phylogenetic analysisGenotype 1 and 4 has a poorer prognosis and response to
interferon therapyIn Hong Kong, genotype 1 accounts for around 67% of cases
and genotype 6 around 25%.
![Page 52: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/52.jpg)
HCV replicates exclusively in the cytoplasmvia an RNA intermediate
Nucleus
Viral entry & uncoating
Translation & processing(+)
(+)
(-)
(+)
HCV RNAreplicationVirus particle
assembly Replicativeintermediate
![Page 53: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/53.jpg)
Clinical Features of HCV Infectionin Children
• Acute infection is rarely symptomatic• Chronic infection is rarely symptomatic
– chronic fatigue may be difficult to assess– extrahepatic manifestations are much less
common than in adults
![Page 54: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/54.jpg)
Incubation period:Range 2-26 wks Average
6-7 wks
Clinical illness (jaundice): 30-40% (20-30%)
Chronic hepatitis: 70%
Persistent infection: 85-100%
Immunity: No protective
antibody
response identified
Hepatitis C - Clinical Features
![Page 55: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/55.jpg)
Hepatitis C
– Nausea– Loss of appetite– Vomiting– Fatigue– Fever– flu-like symptoms– muscle pain– joint pain
– Dark urine– Pale stool– Jaundice– Stomach pain– Side pain– cognitive changes– depression,– headaches, – and mood swings.
• Symptoms
3 out of 4 persons have no symptoms and can infect others without knowing it
![Page 56: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/56.jpg)
Laboratory examination
Liver function Serum transaminase
• ALT(alanine transferase) ↑• AST(aspartase transferase) ↑• ALP (Alkaline phosphatase) ↑• in chronic hepatitis LDH (Lactate dehydrogenase) ↑
Serum protein • Albumin ↓• In chronic hepatitis Ig ↑↑• The ratio of A/G ↓
Bilirubin • Urobilinogen ↑in early stage of AIH
![Page 57: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/57.jpg)
Hepatitis A • Serologic marker
– Anti-HAVIgM: recent infection
– Anti-HAVIgG: past infection
• Marker of feces – HAV particles may be
detected by RIA or IEM
– Isolation of HAV may use tissue culture or animal inoculation
Hepatitis B• Sero-immunologic marker
– HBsAg anti-HBs– HBcAg anti-HBc– HBeAg anti-Hbe
• Molecular biological marker – DNAp– HBV DNA– Immune tissue chemistry
examination
Detection of the markers of hepatitis virus:
![Page 58: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/58.jpg)
Hepatitis C• Serological marker
– Anti-HCVIgM– Anti-HCVIgG
• Molecular biologic marker– HCV RNA may be detective
by RT-PCR 1-2 weeks after infection of HCV
– Quality of HCV RNA– Immune tissue chemistry
method detect HCAg within liver cells
Hepatitis D• HDAg anti-HDV• HDV RNA
Hepatitis E• Anti-HEVIgG,Anti-HEVIgm• RT-PCR• HEV particais: IF IEM
![Page 59: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/59.jpg)
Hepatitis C
• Long term pathogenesis– Over time progressive liver damage may occur– 20 -30 % of those infected will develop cirrhosis
over 10 - 30 years – Of those with cirrhosis 25-30% (5% of overall) will
develop end-stage liver disease or liver cancer– Many live without symptoms for decades– Others experience mild symptoms --intermittent
fatigue, nausea, joint, muscle aches, skin allergies
![Page 60: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/60.jpg)
60
Symptoms
anti-HCV
ALT
Normal
0 1 2 3 4 5 6 1 2 3 4
Hepatitis C Virus InfectionTypical Serologic Course
Titre
Months Years
Time after Exposure
![Page 61: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/61.jpg)
• Because HCV immunoglobulin G antibodies can cross the placenta, it is not useful to test neonates for potential mother-to-infant transmission until the infant is 18 months of age; at this time, the initial test should be for anti-HCV immunoglobulin G If this test is positive, then HCV RNA levels should be measured.
• Screening for HCV should be considered for children born to mothers who have HCV or use intravenous drugs, children with human immunodeficiency virus, illicit drug users, patients with a history of incarceration or other high-risk behaviors, international adoptees or immigrants from high-prevalence areas (e.g., Africa and Asia), individuals with unexplained or prolonged serum transaminase elevations, and patients with needle stick injuries.
![Page 62: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/62.jpg)
62
Laboratory Diagnosis• HCV antibody - generally used to diagnose hepatitis C
infection. Not useful in the acute phase as it takes at least 4 weeks after infection before antibody appears.
• HCV-RNA - various techniques are available e.g. PCR and branched DNA. May be used to diagnose HCV infection in the acute phase. However, its main use is in monitoring the response to antiviral therapy.
• HCV-antigen - an EIA for HCV antigen is available. It is used in the same capacity as HCV-RNA tests but is much easier to carry out.
![Page 63: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/63.jpg)
63
HCV RNA (PCR testing)
Virus load Lower detection limit can be 10-615 IU/ml
NOT a predictor of disease severity: a high viralload does not mean the liver disease is moresevere, and a low viral load does not mean thepatient is ok and does not need therapy!
Helps predict response rate to treatment (lowermeans a higher chance of cure with therapy)
Used to monitor response during treatment
![Page 64: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/64.jpg)
64
Prognostic Tests• Genotyping – genotype 1 and 4 have a worse
prognosis overall and respond poorly to interferon therapy. A number of commercial and in-house assays are available.
– Genotypic methods – DNA sequencing, PCR-hybridization e.g. INNO-LIPA.
– Serotyping – particularly useful when the patient does not have detectable RNA.
• Viral Load – patients with high viral load are thought to have a poorer prognosis. Viral load is also used for monitoring response to IFN therapy.
![Page 65: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/65.jpg)
TREATMENT
• Although adults with genotype 1 CHC have a range of treatment options, including direct-acting antivirals (DAAs), these drugs have not been approved for use in children, nor have they been tested in the pediatric population. Instead, the mainstay of treatment for children is the Food and Drug Administration approved combination of PEG-IFN and ribavirin (RBV).
• At the same time, the decision to treat children can still be challenging because the disease progresses slowly in childhood, serious complications from CHC are rare during childhood, and side effects from treatment are common -
![Page 66: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/66.jpg)
66
TreatmentCHILDREN
• INTERFERON –
• . The response rate is around 50% but 50% of responders will relapse upon withdrawal of treatment.
• RIBAVIRIN a combination of interferon and ribavirin is more effective than interferon alone.
ADULTS
• TELAPREVIR/BOCEPREVIR ( not for naive genotype 1), SOFOSBUVIR, SIMEPREVIR
• NEW TREATMENTS INTERFERON-FREE
![Page 67: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/67.jpg)
Recommendations for adults
• Genotype 1• Recommended regimen for treatment-naive patients with HCV genotype 1
who are eligible to receive IFN.• Daily sofosbuvir (400 mg) and weight-based RBV (1000 mg [<75 kg] to
1200 mg [>75 kg]) plus weekly PEG for 12 weeks is recommended for IFN-eligible persons with HCV genotype 1 infection, regardless of subtype.
• Rating: Class I, Level A• Sofosbuvir is a prodrug of a nucleotide analogue inhibitor of the HCV NS5B
RNA-dependent RNA polymerase.
![Page 68: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/68.jpg)
Recommendations for adults
• Recommended regimen for treatment-naive patients with HCV genotype 1 who are not eligible to receive IFN.
• Daily sofosbuvir (400 mg) plus simeprevir (150 mg), with or without weight-based RBV (1000 mg [<75 kg] to 1200 mg [>75 kg] for 12 weeks is recommended for IFN-ineligible patients with HCV genotype 1 infection, regardless of subtype.
• Rating: Class I, Level B
![Page 69: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/69.jpg)
Recommendations for adults
• Alternative regimens for treatment-naive patients with HCV genotype 1 who are eligible to receive IFN.
• Daily simeprevir (150 mg) for 12 weeks and weight-based RBV (1000 mg [<75 kg] to 1200 mg [>75 kg]) plus weekly PEG for 24 weeks is an acceptable regimen for IFN-eligible persons with either
• HCV genotype 1b or• HCV genotype 1a infection in whom the Q80K polymorphism
is not detected prior to treatment.• Rating: Class IIa, Level A
![Page 70: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/70.jpg)
Recommendations for adults
• Alternative regimens for treatment-naive patients with HCV genotype 1 who are not eligible to receive IFN.
• Daily sofosbuvir (400 mg) and weight-based RBV (1000 mg [<75 kg] to 1200 mg [>75 kg]) for 24 weeks is an acceptable regimen for IFN-ineligiblepersons with HCV genotype 1 infection, regardless of subtype; however, preliminary data suggest that this regimen may be less effective than daily sofosbuvir (400 mg) plus simeprevir (150 mg), particularly among patients with cirrhosis.
• Rating: Class IIb, Level B
![Page 71: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/71.jpg)
Recommendations for adults
• Recommended regimen for treatment-naive patients with HCV genotype 2, regardless of eligibility for IFN therapy:
• Daily sofosbuvir (400 mg) and weight-based RBV (1000 mg [<75 kg] to 1200 mg [>75 kg]) for 12 weeks is recommended for treatment-naive patients with HCV genotype 2 infection.
• Rating: Class I, Level A
![Page 72: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/72.jpg)
Recommendations for adults
• Recommended regimen for treatment-naive patients with HCV genotype 3, regardless of eligibility for IFN therapy:
• Daily sofosbuvir (400 mg) and weight-based RBV (1000 mg [<75 kg] to 1200 mg [>75 kg]) for 24 weeks is recommended for treatment-naive patients with HCV genotype 3 infection.
• Rating: Class I, Level B
![Page 73: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/73.jpg)
Recommendations for adults
• Alternative regimens for treatment-naive patients with genotype 3 who are eligible to receive IFN.
• Daily sofosbuvir (400 mg) and weight-based RBV (1000 mg [<75 kg] to 1200 mg [>75 kg]) plus weekly PEG for 12 weeks is an acceptable regimen for IFN-eligible persons with HCV genotype 3.
![Page 74: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/74.jpg)
74
OUTCOMES of HCV hepatitis
![Page 75: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/75.jpg)
75
Screening of blood, organ, tissue donors
High-risk behavior modification
Blood and body fluid precautions
Prevention of Hepatitis C
![Page 76: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/76.jpg)
76
HEPATITIS D VIRUS(HDV, DELTA AGENT)
VIRION: spherical, 36-38 nm,HBV capsid, HDV nucleoproteinNUCLEIC ACID: (-) ss RNA, circularSatellite virus : replicates onlyin the presence of HBV
![Page 77: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/77.jpg)
77
Hepatitis D Virus• The delta agent is a defective virus which
shows similarities with the viroids in plants.
• The agent consists of a particle 35 nm in diameter consisting of the delta antigen surrounded by an outer coat of HBsAg.
• The genome of the virus is very small and consists of a single-stranded RNA
![Page 78: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/78.jpg)
78
– .–Coinfection– severe acute disease low risk of chronic
infection.
Superinfection–usually develop chronic HDV infection.–high risk of severe chronic liver disease.–may present as an acute hepatitis.
Hepatitis D - Clinical Features
![Page 79: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/79.jpg)
Consequences of hepatitis B and delta virus
infection
![Page 80: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/80.jpg)
80
Percutaneous exposures
injecting drug use
Permucosal exposuressex contact
Hepatitis D Virus Modes of
Transmission
![Page 81: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/81.jpg)
CIRRHOSIS OF LIVER
![Page 82: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/82.jpg)
Etiology of child’s cirrhosis• Hepatitis B and C• Autoimmune hepatitis• Inherited diseases:
– Glycogen storage disease– Tyrosinemia– Wilson disease– Alpha1-antitrypsin deficiency– Cystic fibrosis
• Bile duct diseases:– Biliary artresia– Sclerosing cholangitis– Congenital hepatic fibrosis– Choledochal cysts
• Drugs and toxins: – Isoniazid– Methotrexate– Excess vitamin A
• Fatty liver disease
![Page 83: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/83.jpg)
CirrhosisDefinition: It is the end stage of liver disease characterized
by
Bridging fibrous septa in the form of delicate bands or broad scar linking portal tracts with one another and portal tracts with terminal hepatic vein
Parenchymal nodules containing hepatocytes encircled by fibrosis
Disruption of architecture entire of liver
![Page 84: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/84.jpg)
Normal Liver
![Page 85: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/85.jpg)
Normal Liver Histology
CV
PT
![Page 86: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/86.jpg)
• Histological classificationMicronodular Cirrhosis :Thick regular
septa and regenerating small nodules varying little in size and involvement of every lobule, mainly seen in alcoholic cirrhosis.
Size of the nodule is less than 1cm
![Page 87: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/87.jpg)
Histological classification
Micronodular Cirrhosis
![Page 88: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/88.jpg)
Histological classification
Macronodular Cirrhosis :Septa and nodules of variable size and normal lobules in larger nodules, mainly seen in post necrotic cirrhosis.
Size of the nodule is more than 1cm
![Page 89: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/89.jpg)
Liver Biopsy – Cirrhosis
![Page 90: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/90.jpg)
Liver Biopsy – Cirrhosis:
![Page 91: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/91.jpg)
![Page 92: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/92.jpg)
Clinical Feature of cirrhosisSigns:
Jaundice
Fetor hepaticus
Pedal oedema
Generalized wasting
Hands: Leuconychia, clubbing, Jaundice, Flapping tremor, palmar erythema, dupuytren’s contructure
![Page 93: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/93.jpg)
Clinical Feature of cirrhosis
Parotid enlargement Loss of secondary sexual hair, axillary and pubicGynaecomastia in boys and breast atrophy in
females.Testicular atrophy in males.skin: spider naevi in the upper limbs and chest,
generalized pigmentation, purpura, bruising
![Page 94: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/94.jpg)
Clinical Feature of cirrhosis
Abdomen :
Dilated abdominal vessels, caput medusa
Ascitis
Splenomegaly
Hepatomegaly
Haemorrhoid
• Ascites is suggested by the following findings on physical examination:
• Abdominal distention• Bulging flanks• Shifting dullness• Elicitation of a "puddle
sign" in patients in the knee-elbow position
![Page 95: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/95.jpg)
Palmar erythema
![Page 96: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/96.jpg)
Ascitis in Cirrhosis
![Page 97: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/97.jpg)
Porta-systemic anastomosis: Prominent abdominal veins.
![Page 98: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/98.jpg)
Splenomegaly in cirrhosis
![Page 99: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/99.jpg)
Grade 0 - Subclinical; normal mental status but minimal changes in memory, concentration, intellectual function, coordinationGrade 1 - Mild confusion, euphoria or depression, decreased attention, slowing of ability to perform mental tasks, irritability, disorder of sleep pattern (ie, inverted sleep cycle)Grade 2 - Drowsiness, lethargy, gross deficits in ability to perform mental tasks, obvious personality changes, inappropriate behavior, intermittent disorientation (usually with regard to time)
Grade 3 - Somnolent, but arousable, state; inability to perform mental tasks; disorientation with regard to time and place; marked confusion; amnesia; occasional fits of rage; speech is present but incomprehensibleGrade 4 - Coma, with or without response to painful stimuli
![Page 100: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/100.jpg)
Lab investigations
Liver function: serum albumin and prothrombin are the best indicator of liver functions. o Albumin is less than 28 g/loProthrombin time increase according to the
severity of the diseaseoSerum bilirubin is elevated
Liver biochemistry: this can be normal depending on the severity of the cirrhosisoALP is elevatedoALT is elevated
![Page 101: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/101.jpg)
Lab investigations
Serum electrolytes: A low sodium indicate severe disease due to defect in the free water clearance or excess diuretic therapy.
Serum Creatinine: An elevation concentration of more than 130micromol/l indicate worse prognosis
In addition Alpha feto protein more than 200ng/ml strongly suggest that hepato cellular carcinoma
![Page 102: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/102.jpg)
Lab investigations Other test to identify the cause
Viral marker : HBsAg,Anti HCV
Alpha-1 antitripsin
Serum copper, Caeruloplasmin
Serum immunoglobulin
Auto antibody
Iron indices,ferritin
![Page 103: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/103.jpg)
Imaging
• Ultrasonogram examinition:– Liver may show coarse ecotexture– Dilated portal veins– Splenomegaly– Ascitis
• CT scan may show hepatosplenomegaly and dilated collaterals are seen in chronic liver disease
• Upper GI endoscopy: Oesophageal varices may seen • Liver stiffness measurement in children using FibroScan• LIVER BIOPSY IS CONFIRMATORY
![Page 104: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/104.jpg)
Prognosis of CirrhosisPoor prognostic indicator of cirrhosis: Blood tests
low Serum albumin is( <28 g/l) Low Sodium is (<125mmol/l) Prolonged prothrombin time(> 6sec) Serum Creatinine is (> 130micromol/l)
Clinical Persistent jaundice Ascitis Failure of response to therapy Hemorrhage from the varices, particularly with poor liver function
![Page 105: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/105.jpg)
Prognosis of Cirrhosis
• Prognosis can be assessed by using CHILD-PUGH CLASSIFICATION
Parameter
Ascitis None Mild Moderate/ Severe
Encephalopathy None Mild Marked
Bilirubin <2mg/dl 2-3mg/dl >3mg/dl
Albumin >3.5g/dl 2.8-3.5g/dl <2.8g/dl
Prothrombin time <4 4-6 >6
![Page 106: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/106.jpg)
Prognosis of Cirrhosis
• Score 5-6 grade A (well-compensated disease)
• Score 7-9 grade B (Significant functional compromise)
• Score 10-15 grade C (Decompensated disease)
![Page 107: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/107.jpg)
Complication of cirrhosis
1. Ascitis2. Spontaneous bacterial peritonitis3. Heamatemesis4. Encephalopathy5. Hepatocellular carcinoma6. Hepato renal syndrome 7. Increased susceptibility of infection
![Page 108: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/108.jpg)
TREATMENT
- acide ursodesoxycholique 15 mg/kg/jour• Prednisone and azathioprine - For autoimmune
hepatitis• Interferon and other antiviral agents - For hepatitis B
and C• Phlebotomy - For hemochromatosis• Ursodeoxycholic acid - For primary biliary cirrhosis• Trientine and zinc - For Wilson disease• Liver transplantation
![Page 109: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/109.jpg)
FULMINANT HEPATIC FAILURE
![Page 110: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/110.jpg)
Symptoms•Altered mental status and coagulopathy in the
setting of acute hepatic disease•Fulminant considered <8 wks from jaundice to
encephalopathy•Subfulminant <26 weeks• Jaundice•Encephalopathy – stupor , coma•Decreased synthetic function with INR>1.5•New ascites
![Page 111: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/111.jpg)
Differential diagnosis• Vascular: Budd-Chiari (hepatic vein thrombosis), ischemia “shock liver”,
hepatic veno-occlusive dz, portal vein thrombosis, arterial thrombosis• Infectious: Hepatitis A/B, HSV, CMV, EBV, Hemorrhagic fever viruses
(ebola, lhassa, marburg), paramyxoviruses. Toxoplasma, Leptospira, Candida, Brucella, Myobacteria
• Trauma: laceration• Autoimmune/Inflam: Autoimmune hepatitis, Reye syndrome , onset
Still’s dZ• Inherited/Cong: Wilson’s disease, hemachromatosis, alpha-1
antitrypsin def., galactosemia, tyrosinemia, urea cycle disorders (ornithine transcarbamylase def.), fructose intolerance
• Neoplastic: Primary vs metastatic lesions• Drugs/toxins
![Page 112: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/112.jpg)
Differential: Drugs/Toxins
• Acetaminophen• Alcohol (chronic use depletes glutathione
stores)• Antidepressants: amitriptyline, nortriptyline• Oral hypoglycemics: roglitazone, troglitazone• Antiepileptics: phenytoin, valproate• Antibiotics: tetracycline, amox/clav, cipro,
doxy, erythromycin, isoniazid, nitrofurantoin
![Page 113: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/113.jpg)
TOXINS
• Anesthetic agents: halothane• Statins • Immunosuppressants: cyclophosphamide,
methotrexate• Salicylates: Reye syndrome• Gold• Disulfiram• Propylthiouracil
![Page 114: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/114.jpg)
Toxins: continued…
Dose dependent toxin mediatedBacillus cereus toxin Cyanobacteria toxin Organic solvents (eg, carbon tetrachloride) Yellow phosphorus (fireworks)Amanita phalloides mushroom toxinGalerina mushrooms
Illicit DrugsEcstasyCocaine
Herbal SupplementsGinseng Pennyroyal oil Teucrium polium Chaparral or germander tea Kava Kava (kawa kawa)
![Page 115: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/115.jpg)
Epidemiology
• Caucasian (72%) > Hispanic > African American> Asian• Toxin mediated #1 in US
▫ Acetaminophen 42%▫ Idiosyncratic drug 12% ▫ Hepatitis B▫ Autoimmune hepatitis▫ Wilson’s disease▫ Fatty liver dz of pregnancy, HELLP
• Worldwide▫ HBV +/- HDV▫ HEV (particularly in pregnant women in Mexico, Central America, India, SE Asia)▫ Acetaminophen in Europe, Great Britain
![Page 116: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/116.jpg)
Pathology
• Panlobular necrosis common in medication related and virally mediated disease
• Centrilobular necrosis extending along the portal tracts common in acetaminophen toxicity
• Microvesicular steatosis suggests valproate or salicylates as primary injury or acute fatty liver of pregnancy
![Page 117: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/117.jpg)
Laboratory Studies
• Capillary glucose• Ammonia• Chemistry • Liver panel w/albumin• Lipase• Coags (INR >1.5)• Type & screen• CBC • Lactate• Pregnancy test
• Acetaminophen & salicylate level• Toxicology screen• Viral serologies: anti-
– HAV IgM– HBV surf ag/ab, core IgM– HEV
• ANA, ASMA, LKMA, Ig levels• Ceruloplasmin (acute phase rxct)• Serum free copper• HIV• Blood cultures
![Page 118: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/118.jpg)
Radiology
• CT Head: cerebral edema, mass lesions• Liver u/s with dopplers: eval clot, parenchyma• Liver CT vs MRI: delineate anatomy for possible
transplantation• EEG: seizures
![Page 119: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/119.jpg)
Complications
• Coagulopathy • Encephalopathy• Cerebral edema and herniation• Hypoglycemia• Renal failure• Systemic Inflammatory Response Syndrome (SIRS)
low SVR• Sepsis
![Page 120: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/120.jpg)
Cerebral Edema
• Vasogenic and cytotoxic in origin• Ammoniaglutamine which accumulates in
cortical astrocytes• Increased cerebral blood flow via
– NO2– TNF alpha– IL6– IL2– bacterial endotoxin
![Page 121: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/121.jpg)
Initial management
• Labs as indicated• Triage to appropriate service: consider ICU
when grade II encephalopathy is present for freq neuro checks
• N-acetylcysteine• Intubation if GCS <8, grade III encephalopathy • Use short-acting , low dose meds only• Head CT
![Page 122: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/122.jpg)
Encephalopathy
– Grade I• Confused, altered mood
– Grade II: • Inappropriate, drowsy
– Grade 3: • stuporous but arousable, markedly confused
– Grade 4: • Coma, unresponsive to pain
![Page 123: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/123.jpg)
Mangement: AntidotesN-acetylcysteine
• Load 140mg/kg, then 15mg/kg/hr • Pharmacy infusion protocol (call them!)
![Page 124: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/124.jpg)
Management: Antidotes
• Amanita = Penicillin G (mech unknown) 1mg/kg/d +/- activated charcoal
• Silibinin – derivative of milk thistle, antioxidant (proposed but not well studied)
• Inchinko-to – Chinese herbal preparation for cholestatic hepatitis (proposed suppression of TNF-α, inhibition of hepatic apotosis)
![Page 125: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/125.jpg)
Management: Coagulopathy
• Correction of coagulopathy not indicated unless active bleeding is present or procedure– FFP ( fresh frozen plasma) 15ml/kg or 4 units– cryoprecipitate– Factor VIIa for unresponsive bleeding 4mcg/kg
push– Platelet transfusion only <10K or procedure <50K
![Page 126: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/126.jpg)
Management: Renal Failure
• 1/3 of patients will develop oliguric ARF• Fluid resusciation• CVVHD (Continuous veno-venous
hemodialysis) as indicated • Avoid nephrotoxic medications• Avoid NSAIDS
![Page 127: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/127.jpg)
Management: CV and Endocrine
• Fluid resuscitation• Low SVR with normal or increased CO• Dopamine or norepinephrine prn
• Impaired gluconeogenesis• Frequent capillary blood glucose q1/2 • D5/10 containing solution as necessary• Montior potassium, phosphate and
magnesium
![Page 128: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/128.jpg)
Management: Antibiotics
– Empiric antibiotics for • Progressive encephalopathy • Signs of SIRS (temperature, >38ºC or <36ºC; white
blood cell [WBC] count, >12,000/μL or <4000/μL; pulse rate, >90 bpm)
• Persistent hypotension– Zosyn( Piperacillin/tazobactam) and fluconazole
considered initially. In hospital-acquired IV catheter infections, consider vancomycin.
![Page 129: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/129.jpg)
Management: Cerebral edema
• Lactulose via NG to decrease ammonia• Mechanical ventilation to protect airway and hyperventilate
(short-lived)• Head of bed elevated to 30 degrees• Mannitol (0.5 - 1g/kg) goal osm around 320• Hypertonic saline 3% ( goal na 145-155)• Barbituate coma• Hypothermia is under investigation• Seizure control with phenytoin• Call neurology/neurosurgery early• Refractory increased ICP or decreased CPP is a contra-
indication for transplantation in most centers
![Page 130: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/130.jpg)
Prognosis: King’s College Criteria
Acetaminophen toxicity• Arterial lactate >3.5 4 hrs after resuscitation
or• pH <7.30 or lactate >3.0 12 hours after
resuscit. or– Arterial pH <7.3– PT >100 sec– Creatinine >3.4
![Page 131: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/131.jpg)
Non-acetaminophen related toxicity• INR >6.5 (PTT>100) or• Arterial lactate >3.5 4hrs after resuscitation or •3 of 5
▫Age <10 or >40▫INR >3.5▫Idiosyncratic drug rxn▫Jaundice > 1wk ▫Serum bilirubin >17.5mg/dL
![Page 132: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/132.jpg)
MELDModel for End-Stage Liver Disease
•3.78[Ln serum bilirubin (mg/dL)] + 11.2[Ln INR] + 9.57[Ln serum creatinine (mg/dL)] + 6.43
•Utilized to prioritize transplant recipients• In hospitalized patients, the 3 month mortality is:
▫40 or more — 100% mortality ▫30–39 — 83% mortality ▫20–29 — 76% mortality ▫10–19 — 27% mortality ▫<10 — 4% mortality
![Page 133: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/133.jpg)
METAVIR score• Portal (piecemeal necrosis) Lobular activity ACTIVITY GRADE **
• 0 none none or mild A0: no PN or lobular activity
1 focal PN, some tracts at least 1 focus per lobule A1: mild PN (grade 1)
2 diffuse PN some tracts OR multiple foci per lobule OR A2: moderate• PN (grade2)• focal PN all tracts bridging necrosis OR lobular • grade 2
•3 diffuse PN all tracts A3: PN grade 2 & lobular gr 2 • OR severe PN (grade 3)
•Fibrosis •F0 no fibrosis •F1 portal fibrosis without septa •F2 portal fibrosis with rare septa •F3 numerous septa without cirrhosis •F4 cirrhosis•
![Page 134: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/134.jpg)
• C. Ishak (modified Knodell) score• Necroinflammatory score • A 0-4 Periportal or periseptal interface hepatitis (piecemeal necrosis) • B 0-6 Confluent necrosis • C 0-4 Focal (spotty) lytic necrosis, apoptosis, focal inflammation • D 0-4 Portal inflammation • • Fibrosis stage • 0 No fibrosis • 1 fibrous expansion of some portal areas (with or without spurs) • 2 fibrous expansion of most portal areas (with or without spurs) • 3 fibrous expansion of most portal areas with occasional portal-portal linkage • 4 fibrous expansion of portal areas with marked portal-portal and some portal-
central linkage • 5 marked bridging (P-P and P-C) with occasional nodules (incomplete cirrhosis) • 6 cirrhosis
![Page 135: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/135.jpg)
Management: Transplant
• Prior to orthotopic txplt, mortality >80%• 6% of OLT due to fulminant hepatic failure• Mortality now around 20-40% center
dependent
• CALL THE TRANSPLANT TEAM TO DISCUSS THE CASE
![Page 136: CRONIC HEPATITIS, CIRRHOSIS, HEPATIC FAILURE ASSOC. PROF. DR. INGRID MIRON](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649dc75503460f94abcb7b/html5/thumbnails/136.jpg)
REMEMBER:
•Fulminant hepatic failure is incredibly deadly so triage and treat aggressively
•Get other smart people involved quickly•Don’t forget about metabolic disorders causing elevated
ammonia levels (urea cycle)•Look for other causes when the patient doesn’t fit with
expected course▫History▫Review▫History
• Think