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CRISPR Immunity Relies on the Consecutive Binding and Degradation of Negatively Supercoiled Invader DNA by Cascade and Cas3 Edze R. Westra, Paul B.G. van Erp, Tim Künne, Shi Pey Wong, Raymond H.J. Staals, Christel L.C. Seegers, Sander Bollen, Matthijs M. Jore, Ekaterina Semenova, Konstantin Severinov, Willem M. de Vos, Remus T. Dame, Renko de Vries, Stan J.J. Brouns, John van der Oost Molecular Cell Volume 46, Issue 5, Pages 595-605 (June 2012) DOI: 10.1016/j.molcel.2012.03.018 Copyright © 2012 Elsevier Inc. Terms and Conditions

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Page 1: CRISPR Immunity Relies on the Consecutive Binding and Degradation of Negatively Supercoiled Invader DNA by Cascade and Cas3 Edze R. Westra, Paul B.G. van

CRISPR Immunity Relies on the Consecutive Binding and Degradation of Negatively Supercoiled Invader DNA by Cascade and Cas3 

Edze R. Westra, Paul B.G. van Erp, Tim Künne, Shi Pey Wong, Raymond H.J. Staals, Christel L.C. Seegers, Sander Bollen, Matthijs M. Jore, Ekaterina Semenova, Konstantin Severinov, Willem M. de Vos, Remus T. Dame, Renko de Vries, Stan J.J. Brouns, John

van der Oost 

Molecular Cell Volume 46, Issue 5, Pages 595-605 (June 2012)

DOI: 10.1016/j.molcel.2012.03.018

Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 2: CRISPR Immunity Relies on the Consecutive Binding and Degradation of Negatively Supercoiled Invader DNA by Cascade and Cas3 Edze R. Westra, Paul B.G. van

Figure 1

Molecular Cell 2012 46, 595-605DOI: (10.1016/j.molcel.2012.03.018) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 3: CRISPR Immunity Relies on the Consecutive Binding and Degradation of Negatively Supercoiled Invader DNA by Cascade and Cas3 Edze R. Westra, Paul B.G. van

Figure 2

Molecular Cell 2012 46, 595-605DOI: (10.1016/j.molcel.2012.03.018) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 4: CRISPR Immunity Relies on the Consecutive Binding and Degradation of Negatively Supercoiled Invader DNA by Cascade and Cas3 Edze R. Westra, Paul B.G. van

Figure 3

Molecular Cell 2012 46, 595-605DOI: (10.1016/j.molcel.2012.03.018) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 5: CRISPR Immunity Relies on the Consecutive Binding and Degradation of Negatively Supercoiled Invader DNA by Cascade and Cas3 Edze R. Westra, Paul B.G. van

Figure 4

Molecular Cell 2012 46, 595-605DOI: (10.1016/j.molcel.2012.03.018) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 6: CRISPR Immunity Relies on the Consecutive Binding and Degradation of Negatively Supercoiled Invader DNA by Cascade and Cas3 Edze R. Westra, Paul B.G. van

Figure 5

Molecular Cell 2012 46, 595-605DOI: (10.1016/j.molcel.2012.03.018) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 7: CRISPR Immunity Relies on the Consecutive Binding and Degradation of Negatively Supercoiled Invader DNA by Cascade and Cas3 Edze R. Westra, Paul B.G. van

Figure 6

Molecular Cell 2012 46, 595-605DOI: (10.1016/j.molcel.2012.03.018) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 8: CRISPR Immunity Relies on the Consecutive Binding and Degradation of Negatively Supercoiled Invader DNA by Cascade and Cas3 Edze R. Westra, Paul B.G. van

Figure 7

Molecular Cell 2012 46, 595-605DOI: (10.1016/j.molcel.2012.03.018) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions

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