cowden syndrome: case report

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PE-090 - CONSEQUENCES OF NONADHERENCE TO TREATMENT FOR SQUAMOUS CELL CARCINOMA: CASE REPORT. GUSTAVO GOMES AGRIPINO, ODAILMA DA SILVA LIMA, SANDRA APARECIDO MARINHO, DMITRY JOSÉ DE SANTANA SARMENTO, SÉRGIO HENRIQUE GONÇALVES DE CARVALHO, TATIANA STUART HOLMES, MANUEL ANTONIO GORDON- NÚÑEZ. UNIVERSIDADE ESTADUAL DA PARAÍBA. Patient cooperation and adherence to treatment are essential to improving the prognosis of malignant tumors with a late diagnosis. Woman, 89, was sent to the UEPB, Araruna/PB, with an extensive labial tumor. Clinical examination revealed an ul- cerative, scabby tumor on the upper lip and in the oropharynx. The diagnosis was well-differentiated squamous cell carcinoma- T4N0M0. The patient was sent for cancer treatment, which was planned to include surgical removal of the labial tumor and radiotherapy for the intraoral lesions. The patient permitted the surgical removal of the labial tumor, but refused to undergo radiotherapy. After 9 months, even with a submandibular lymph node metastasis, the patient continued to refuse treatment, which resulted in growth of the tumor and ulceration of the sublingual lymph node, followed by death 12 months after the diagnosis. The patients refusal of treatment adversely affected her survival. PE-091 - CONSERVATIVE MANAGEMENT OF LARGE- SIZED MANDIBULAR ODONTOGENIC MYXOMA: CASE REPORT. DESIREE CAVALCANTI, ANDRE CAROLI ROCHA. ORAL SPECIALTIES CENTER OF SUZANO, HOSPITAL OF THE FACULTY OF MEDICINE, UNIVER- SITY OF SÃO PAULO. Odontogenic myxoma (OM) is a locally aggressive benign tumor found exclusively in the jaws. The radiographic and clinical features are variable, as is the biological behavior, making it difcult to di- agnose in the early stages. Large lesions may cause tooth displacement and cortical bone expansion, which are the main symptoms bringing patients to seek diagnosis. Treatment is surgical excision by enucle- ation, curettage, or en bloc resection. Young man, 17, had OM located in the mandible. To avoid segmental resection, the patient received conservative management (curettage and supercial osteotomy), performed via intraoral access, which preserved a narrow residual cortical segment of the mandible. The patient has been followed up for 5 years and shows signicant growth of the mandibular bone, cortical bone remodeling, and a harmonious facial contour. Rehabilitation included a conventional removable partial denture. PE-092 - CONTRIBUTION OF THE DENTAL EXAMI- NATION IN THE EARLY DIAGNOSIS OF IDIOPATHIC THROMBOCYTOPENIC PURPURA. LUZIA HERMINIA TEIXEIRA DE SOUSA, RODRIGO RODRIGUES RODRIGUES, FRANCISCO SAMUEL RODRIGUES CARVALHO, FILIPE NOBRE CHAVES, THYCIANA RODRIGUES RIBEIRO, KARUZA MARIA ALVES PEREIRA, FÁBIO WILDSON GURGEL COSTA. UNI- VERSIDADE FEDERAL DO CEARÁeUFC. Idiopathic thrombocytopenic purpura (ITP) is dened as isolated thrombocytopenia, with a platelet count less than 100 109/L and no identiable and specic precipitants. ITP in adults has an insidious onset and normally follows a chronic course. Blind man, 56, came to the stomatology clinic for a routine visit. Extraoral examination revealed reddish spots, widespread bruises over the region of the scalp and chest, and petechiae in the n- gers. Intraoral examination showed hemorrhagic blisters in the lower lip and buccal mucosa on the left side, petechiae on the palate, and spontaneous gingival bleeding. Based on these clinical ndings, the patient was transferred to the medical service and ITP was diagnosed. It is important to remember that the oral mucosa may be a primary site of involvement in ITP. PE-093 - CONVENTIONAL CHONDROSARCOMA OF MANDIBLE IN YOUNG PATIENT: CASE REPORT. ALISSON CARDOSO ALVES, FRANCISCO JADSON LIMA, HIARLES BARRETO SAMPAIO BRITO, DALIANA QUEIROGA CASTRO GOMES, CASSIANO FRANCISCO WEEGE NONAKA, GUSTAVO PINA GODOY, POLLIANNA MUNIZ ALVES. UEPB. Chondrosarcomas (CS) are rare malignant tumors charac- terized by cartilage production. Only 3% of CS occurs in the head and neck region. CS usually affects patients beyond the fth decade of life. Histologically, CS tumors are classied as con- ventional, clear cell, myxoid, dedifferentiated, and mesenchymal. Woman, 36, complained of rapidly developing swelling in the posterior mandible. Panoramic radiograph demonstrated a radi- opaque area; computed tomography showed poorly demarcated hyperdense foci next to tooth #46. The proposed diagnosis was bro-osseous lesion. An incisional biopsy and microscopic ex- amination revealed a malignant neoplasm exhibiting extensive areas of hyaline cartilage matrix with mild cellularity. Individu- ally, malignant cells exhibited pleomorphism and hyper- chromatism with bone invasion. The denitive diagnosis was conventional chondrosarcoma. The patient underwent radical surgery and is receiving radiotherapy. It is important to detect CS early to prevent metastases and provide a better quality of life. PE-094 - COWDEN SYNDROME: CASE REPORT. LIANA PRETO WEBBER, SIVANDRO CARLOS TRASEL, VINICIUS COELHO CARRARD, CRISTINA BRINCKMANN OLIVEIRA NETTO, MARCO ANTONIO TREVIZANI MARTINS, MANOELA DOMINGUES MARTINS, MARIA CRISTINA MUNERATO. UFRGS/ HCPA. Cowdens syndrome (multiple hamartoma syndrome) is a rare autosomal-dominant inherited disorder. Clinical features include cutaneous manifestations such as trichilemomma, acral and palmoplantar keratosis, and multiple oral papules. Woman, 37, was referred with a chief complaint of gingival overgrowth and lesions on the upper lip. The patient reported a history of follicular thyroid carcinoma and duodenal polyps. Extraoral ex- amination revealed papules on the vermilion border of the upper lip and keratotic lesions on the face and back of the hands. Intraoral examination found multiple papular lesions involving the lips, tongue, and gums. The initial diagnosis was Heck dis- ease. An incisional biopsy was performed, and the histopatho- logical results suggested broepithelial polyp. The medical history and clinical ndings related to oral lesions supported the diagnosis of Cowden syndrome. It should be emphasized that it is important for dental practitioners to recognize the clinical mani- festation of this disease, allowing for its early diagnosis. PE-095 - COWDEN’S SYNDROME DIAGNOSIS BASED ON ORAL MANIFESTATIONS. THAYS TEIXEIRA DE SOUZA, BRUNA LAVINAS SAYED PICCIANI, GABRIELLA MUNDIM ROCHA DE OLIVEIRA, GERALDO DE OLIVEIRA SILVA-JUNIOR, RUTH TRAMONTANI RAMOS, MARILIA HEFFER CANTISANO, FABIO RAMOA PIRES. UNIVERSIDADE DO ESTADO DO RIO DE JANEIRO. ORAL AND MAXILLOFACIAL PATHOLOGY OOOO e150 Abstracts February 2014

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Page 1: Cowden Syndrome: Case Report

ORAL AND MAXILLOFACIAL PATHOLOGY OOOO

e150 Abstracts February 2014

PE-090 - CONSEQUENCES OF NONADHERENCE TOTREATMENT FOR SQUAMOUS CELL CARCINOMA:CASE REPORT. GUSTAVO GOMES AGRIPINO, ODAILMADA SILVA LIMA, SANDRA APARECIDO MARINHO,DMITRY JOSÉ DE SANTANA SARMENTO, SÉRGIOHENRIQUE GONÇALVES DE CARVALHO, TATIANASTUART HOLMES, MANUEL ANTONIO GORDON-NÚÑEZ. UNIVERSIDADE ESTADUAL DA PARAÍBA.

Patient cooperation and adherence to treatment are essentialto improving the prognosis of malignant tumors with a latediagnosis. Woman, 89, was sent to the UEPB, Araruna/PB, withan extensive labial tumor. Clinical examination revealed an ul-cerative, scabby tumor on the upper lip and in the oropharynx.The diagnosis was well-differentiated squamous cell carcinoma-T4N0M0. The patient was sent for cancer treatment, which wasplanned to include surgical removal of the labial tumor andradiotherapy for the intraoral lesions. The patient permitted thesurgical removal of the labial tumor, but refused to undergoradiotherapy. After 9 months, even with a submandibular lymphnode metastasis, the patient continued to refuse treatment, whichresulted in growth of the tumor and ulceration of the sublinguallymph node, followed by death 12 months after the diagnosis.The patient’s refusal of treatment adversely affected her survival.

PE-091 - CONSERVATIVE MANAGEMENT OF LARGE-SIZED MANDIBULAR ODONTOGENIC MYXOMA:CASE REPORT. DESIREE CAVALCANTI, ANDRE CAROLIROCHA. ORAL SPECIALTIES CENTER OF SUZANO,HOSPITAL OF THE FACULTY OF MEDICINE, UNIVER-SITY OF SÃO PAULO.

Odontogenicmyxoma (OM) is a locally aggressive benign tumorfound exclusively in the jaws. The radiographic and clinical featuresare variable, as is the biological behavior, making it difficult to di-agnose in the early stages.Large lesionsmay cause toothdisplacementand cortical bone expansion, which are the main symptoms bringingpatients to seek diagnosis. Treatment is surgical excision by enucle-ation, curettage, or en bloc resection.Youngman, 17, hadOM locatedin the mandible. To avoid segmental resection, the patient receivedconservative management (curettage and superficial osteotomy),performed via intraoral access, which preserved a narrow residualcortical segment of themandible. The patient has been followedup for5 years and shows significant growth of themandibular bone, corticalbone remodeling, and a harmonious facial contour. Rehabilitationincluded a conventional removable partial denture.

PE-092 - CONTRIBUTION OF THE DENTAL EXAMI-NATION IN THE EARLY DIAGNOSIS OF IDIOPATHICTHROMBOCYTOPENIC PURPURA. LUZIA HERMINIATEIXEIRA DE SOUSA, RODRIGO RODRIGUESRODRIGUES, FRANCISCO SAMUEL RODRIGUESCARVALHO, FILIPE NOBRE CHAVES, THYCIANARODRIGUES RIBEIRO, KARUZA MARIA ALVESPEREIRA, FÁBIO WILDSON GURGEL COSTA. UNI-VERSIDADE FEDERAL DO CEARÁeUFC.

Idiopathic thrombocytopenic purpura (ITP) is defined asisolated thrombocytopenia, with a platelet count less than 100 �109/L and no identifiable and specific precipitants. ITP in adultshas an insidious onset and normally follows a chronic course.Blind man, 56, came to the stomatology clinic for a routine visit.Extraoral examination revealed reddish spots, widespread bruisesover the region of the scalp and chest, and petechiae in the fin-gers. Intraoral examination showed hemorrhagic blisters in the

lower lip and buccal mucosa on the left side, petechiae on thepalate, and spontaneous gingival bleeding. Based on these clinicalfindings, the patient was transferred to the medical service andITP was diagnosed. It is important to remember that the oralmucosa may be a primary site of involvement in ITP.

PE-093 - CONVENTIONAL CHONDROSARCOMA OFMANDIBLE IN YOUNG PATIENT: CASE REPORT.ALISSON CARDOSO ALVES, FRANCISCO JADSON LIMA,HIARLES BARRETO SAMPAIO BRITO, DALIANAQUEIROGA CASTRO GOMES, CASSIANO FRANCISCOWEEGE NONAKA, GUSTAVO PINA GODOY,POLLIANNA MUNIZ ALVES. UEPB.

Chondrosarcomas (CS) are rare malignant tumors charac-terized by cartilage production. Only 3% of CS occurs in the headand neck region. CS usually affects patients beyond the fifthdecade of life. Histologically, CS tumors are classified as con-ventional, clear cell, myxoid, dedifferentiated, and mesenchymal.Woman, 36, complained of rapidly developing swelling in theposterior mandible. Panoramic radiograph demonstrated a radi-opaque area; computed tomography showed poorly demarcatedhyperdense foci next to tooth #46. The proposed diagnosis wasfibro-osseous lesion. An incisional biopsy and microscopic ex-amination revealed a malignant neoplasm exhibiting extensiveareas of hyaline cartilage matrix with mild cellularity. Individu-ally, malignant cells exhibited pleomorphism and hyper-chromatism with bone invasion. The definitive diagnosis wasconventional chondrosarcoma. The patient underwent radicalsurgery and is receiving radiotherapy. It is important to detect CSearly to prevent metastases and provide a better quality of life.

PE-094 - COWDEN SYNDROME: CASE REPORT. LIANAPRETO WEBBER, SIVANDRO CARLOS TRASEL, VINICIUSCOELHO CARRARD, CRISTINA BRINCKMANN OLIVEIRANETTO, MARCO ANTONIO TREVIZANI MARTINS,MANOELA DOMINGUES MARTINS, MARIA CRISTINAMUNERATO. UFRGS/ HCPA.

Cowden’s syndrome (multiple hamartoma syndrome) is arare autosomal-dominant inherited disorder. Clinical featuresinclude cutaneous manifestations such as trichilemomma, acraland palmoplantar keratosis, and multiple oral papules. Woman,37, was referred with a chief complaint of gingival overgrowthand lesions on the upper lip. The patient reported a history offollicular thyroid carcinoma and duodenal polyps. Extraoral ex-amination revealed papules on the vermilion border of the upperlip and keratotic lesions on the face and back of the hands.Intraoral examination found multiple papular lesions involvingthe lips, tongue, and gums. The initial diagnosis was Heck dis-ease. An incisional biopsy was performed, and the histopatho-logical results suggested fibroepithelial polyp. The medicalhistory and clinical findings related to oral lesions supported thediagnosis of Cowden syndrome. It should be emphasized that it isimportant for dental practitioners to recognize the clinical mani-festation of this disease, allowing for its early diagnosis.

PE-095 - COWDEN’S SYNDROME DIAGNOSIS BASEDON ORAL MANIFESTATIONS. THAYS TEIXEIRA DESOUZA, BRUNA LAVINAS SAYED PICCIANI, GABRIELLAMUNDIM ROCHA DE OLIVEIRA, GERALDO DEOLIVEIRA SILVA-JUNIOR, RUTH TRAMONTANI RAMOS,MARILIA HEFFER CANTISANO, FABIO RAMOA PIRES.UNIVERSIDADE DO ESTADO DO RIO DE JANEIRO.