Bionanotechnology and Nanomedicin

Introduction of this course

Course Description This course will cover the physics and chemistry relevant to the

design, synthesis, and characterization of bionanotechnology. Topics include nanoparticle synthesis, functionalization, surface engineering, and applications in diagnostics and therapeutics. The properties of semiconductor quantum dots and magnetic nanoparticles will be reviewed along with techniques for nanoparticle manipulation, particle tracking and their applications in drug delivery.

Patterning tools including soft lithography, optical lithography, e-beam lithography, and template lithography will be discussed. Electron and scanning probe microscopy will be reviewed.

Strategies for functionalization of biosensors are covered with focus on methods for attaching biomolecules. Bio-nanosensors functionalized with biologically-active molecules, genes, antibodies or other proteins, will be used to probe cell function and to develop methods to enhance our ability to deliver bio-active molecules to cells and tissues. The discussions covered will be on areas of human cancers and nanotechnology and include the latest developments from studies of model organisms.

This course allows students the opportunity last week to review and present on special research topics related to nanobiotechnology.

Instructors

1. Prof. Dr. Guang Yang Her current research interest focuses on

Biochemical engineering, Bionic nano-composite, Polymer physics & chemistry, involving in study on nano-assembly of ordered eco-friendly materials and their structures & properties, proceeding control and optimization of bio-refining, design and fabrication of novel nano-drug transporter, tissue engineering scaffold materials for biomedical applications, etc.

Instructors

2. Prof Glyn.O.PhillipsProfessor Phillips' research interests have

centered upon carbohydrate and biomaterial systems, particularly on food hydrocolloids and medically-related biopolymers of connective tissue. He has been a collaborator with Dr Endre A. Balazs since 1963, lately with Biomatrix Inc, (now incorporated into Genzyme Inc) which produced HYLAN, an FDA approved product, which was used for the replacement for synovial fluid damaged by osteoarthritis ( “SYNVISC” ).

Instructors

3. Prof. Mario Gauthier Anionic polymerization: Arborescent

and other graft polymers, telechelic polymers, block copolymers. Stable free-radical polymerization reactions. Emulsion polymerization. Ion-containing polymers: Ionomers, polyelectrolytes. Copolymerization and post-polymerization modification reactions. Polymer characterization: Applications of laser light scattering techniques, size-exclusion chromatography. Rheological properties and mechanical testing. Solution properties.

Instructors

TA. S.Morteza Zendehbad Current research interests are

nanotechnology and nanobiotechnology, biomedical optoelectronic devices. Multi-walled Nano Carbon Tubes and Bacterial Cellulose (MWNCTs & BC); Electrically Conductive Bacterial Cellulose by Incorporation of Carbon Nanotubes; Signal Processing via MATLAB; Renewable Energy

Subjects

Fundamental Physics & Chemistry of bio and nanomaterials

Principle of Electron Microscopy

Surface functionalization – structure polypeptides- naturals biological assembly- self-assembly of bio inspired nanomaterial

History – Terminologies- Principles and methodology - biology application – classification : SEM,TEMAdvance investigation of tools – classification: SPM ,AFM

Subjects Molecular Nanotechnology

Nanoparticles

Nano drug delivery

Collagen, cell, biomolecules ,cytoskeleton, …Biomolecular design and biotechnology

Classification, physical and chemical biological synthesis – QDs –carbon nanotubes, polymers Cancer therapy , Gene technology – florescent detection

History, classification – drug targeting – nanoparticles – BC – liposome…

Subjects Bio-Nano imaging and Diagnostic

Biosensor and biomolecular Electronics

Micro and Nano machining

Classification – MRI – DNA and Protein microarrays- Biomedical Robot for Surgery- Transdermal Patches

History – Terminologies - concept and future prospects –Principle –Classification – controlled release -nanowire - Optical fiber …

MEMS –NEMS – BIOMEMS- biology application –Biochips

References

BioNanotechnology, Elisabeth S. Papazoglou, Aravind Parthasarathy, 2007

Nanobiotechnology, C. M. Niemeyer and C. A. Mirkin, 2004

BIONANOTECHNOLOGY- Lessons from Nature; David S. Goodsell, 2004

NANOTECHNOLOGY IN BIOLOGY AND MEDICINE (Methods, Devices, and Applications), Tuan Vo-Dinh, 2007

TimeEach Week : 2 times and 4 hours 8 hours per weekRegularly : Tuesday and Friday BUT ….

Examination

Presentation Subject: According to several topics of this course Time: 20-25 min for each student Date: 21th and 24th May

Essay Subject: Cover your presentation Submit: Hard and soft version (paper and MS Word) Deadline : 30th May