corticale surrenalica - autistici - presentazioni... · corticale surrenalica . cellule cresta...
TRANSCRIPT
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Corticale surrenalica
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Cellule Cresta
genitale SF1
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SF1
Desmolasi Cyt P450 scc
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GR1 = MR
GR2
Aldosterone
HSD2
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Asse HPA
CRH 41aa
CRHR1 Chr17
CRHR2 Chr 7
14 esoni
4 forme splicing
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Urocortina e urotensina
Endorfine
SS
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POMC
Ipofisi Ipotalamo sistema immunitario --> derma
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Lipotrofina e endorfina
Gs Gi
δ σ ε µ
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MSH
αMSH 14aa (13aa)--> pigmentazione
βMSH 22aa --> controllo alimentare animali da letargo pars intermedia
γMSH 12aa
MCR1 --> pigmentazione
MCR2 -->lega ACTH
MCR3 -->
MCR4 --> controllo alimentare (agonista inverso AgRP)
MCR5
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ACTH
CRF ANP- BNP (urodilatina)
<---CRF
Urocortina Urotensina
GIP IL-1 Il-6 INF
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ACTH recettore
MCR2 (ACTHRecpt) Chr18
1 singolo esone coding region
(MCR1 bassa affinità)
Gs Gq (βγ)
Corticale surrenalica
Gastroenterico
Immunitario
Isole pancreatiche
Midollare surrenalica
SNC
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Gs
Gq DAG PI3 Fattori di crescita IGF1
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Recettori GR
GR1 = MR Chr4
MR-α
MR-β
10 esoni splice HSD2 Reni
Ghiand sudoripare
Ghiand salivari
SNC
GR2 Chr5
GR-α lungo
GR-β corto inibitore
GR-P
Splice varianti
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Effetti generali
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GR-a GR-b
Favorisce memoria l’apprendimento
Ansia e depressione
Coinvolto in numerose patologie neurologiche e disordini psichiatrici
MR/GR1
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Effetti metabolici
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Effetto sul tessuto osseo
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Cortisolo e sistema immunitario
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Effetti sistema immunitario
A2 Lipocortina annessina
apoptosi
Diminuita secrezione sostanze chemiotattiche istamina BK SP Diminuita vasodilatazione e permeabilità capillare Diminuita fagocitosi
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Midollare del surrene
vMAT
vMAT
?
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Adrenalina e metabolismo
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Neuro-endocrino-immunoregolazione
GH Prolattina Leptina ACTH TSH PTH Cortisolo T3 D3
IL-1 IL-6 TNF INF
NGF CNTF BDNF NT3
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Stress
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