coronary stents a stent is a support device for permanent expansion of blood vessel to restore...

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Coronary Stents A stent is a support device for permanent expansion of blood vessel to restore blood flow. Implantation is done with X-ray guidance in a Cathlab, which exposes the patient to ionizing radiation and potentially kidney damaging X-ray contrast agents. After implantation, there is currently no way to show a potential restenosis (re-narrowing) of the blood vessel using non-invasive diagnostic systems. Diagnosis requires another catheterization procedure. Stent Implantat ion Biophan’s technology presents an alternative – using an MRI system for diagnosis of restenosis. MRI diagnosis provides advantages, since it is non-invasive and uses no harmful radiation and no iodine contrast agents.

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Page 1: Coronary Stents A stent is a support device for permanent expansion of blood vessel to restore blood flow. Implantation is done with X-ray guidance

Coronary Stents A stent is a support device for permanent

expansion of blood vessel to restore blood flow.

Implantation is done with X-ray guidance in a Cathlab, which exposes the patient to ionizing radiation and potentially kidney damaging X-ray contrast agents.

After implantation, there is currently no way to show a potential restenosis (re-narrowing) of the blood vessel using non-invasive diagnostic systems. Diagnosis requires another catheterization procedure.

StentImplantation

Biophan’s technology presents an alternative – using an MRI system for diagnosis of restenosis. MRI diagnosis provides advantages, since it is non-invasive and uses no harmful radiation and no iodine contrast agents.

Page 2: Coronary Stents A stent is a support device for permanent expansion of blood vessel to restore blood flow. Implantation is done with X-ray guidance

1.5 Tesla MRI Artifacts of Current Stents

Expanded

StentsOriginal size

Crimped

Stents

Cobalt

316L stainless steel

With existing stent

technology, no useful

images can be obtained from within

common stents using

MRI.

Page 3: Coronary Stents A stent is a support device for permanent expansion of blood vessel to restore blood flow. Implantation is done with X-ray guidance

Imaging of In-Stent Blood Clots Using Biophan Resonator Technology

1 Tesla Philips NT, head coil, TR=300ms, TE=6ms, FA=40°,

transversal

Cross Sectional Schematic of Stent with blood clot

Video

Biophan’s technology enables imaging of the blood clot within the stent

Resonant Stent Blood Clot

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