corneal degenerations 1. age-related arcus senilis vogt white limbal girdle 2. lipid keratopathy...
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CORNEAL DEGENERATIONS
1. Age-related• Arcus senilis• Vogt white limbal girdle
2. Lipid keratopathy
• Crocodile shagreen • Cornea guttata
• Primary• Secondary
3. Band keratopathy4. Spheroidal degeneration5. Salzmann nodular degeneration
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Arcus senilis• Innocuous and extremely common in elderly• Occasionally associated with hyperlipoproteinaemia
• Bilateral, circumferential bands of lipid deposits• Diffuse central and sharp peripheral border
• Peripheral border separated from limbus by clear zone
• Clear zone may be thinned ( senile furrow)
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Vogt white limbal girdle• Innocuous and very common in elderly• Bilateral
• White, crescentic line along nasal and temporal limbus• Type 1 - separated from limbus by clear zone• Type 2 - not separated by clear zone
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Crocodile shagreen• Uncommon and innocuous• Usually bilateral
• Polygonal stromal opacities separated by clear space
• Most frequently involve anterior stroma (anterior crocodile shagreen)• Occasionally involve posterior stroma (posterior crocodile shagreen)
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Cornea guttata• Common, bilateral and usually innocuous• Rarely progression to Fuchs dystrophy
• Tiny dark spots on central endothelium• Similar peripheral lesions are Hassell-Henle bodies
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Lipid keratopathy
• Usually unilateral stromal deposits without vascularization
• Rare, occurs spontaneously in avascular cornea
• Unilateral stromal deposits with vascularization
• Common, secondary to previous disciform keratitis
Treatment - coagulation of feeder vessels and/or keratoplasty Treatment - keratoplasty, if severe
Primary Secondary
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Band keratopathy
• Interpalpebral limbal opacification
• Common, unilateral or bilateral depending on cause• Subepithelial calcification
• Central spread of calcification• Small holes within calcified area• Separated by clear zone
Progression
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Causes of Band Keratopathy
1. Ocular (common)
• Silicone oil in anterior chamber
• Increased serum calcium and phosphorus
• Chronic iridocyclitis, particularly in children
• Hyperuricaemia
• Associated with phthisis bulbi
3. Hereditary (rare)
• Chronic renal failure
• Familial band keratopathy• Hereditary ichthyosis
2. Metabolic (rare)
4. Age-related (uncommon)
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Removal of corneal epithelium Application of sodium versenate
Chelation of band keratopathy
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Spheroidal degeneration
Treatment
Central spread, coalescence and opacification
Advanced lesions become nodular and elevated
• Rare, typically affects outdoor workers• Starts with peripheral, interpalpebral, small amber-coloured granules in superficial stroma
• Debridement or superficial keratotomy if mild• Keratoplasty if severe
Progression
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Salzmann nodular degeneration• Uncommon, unilateral or bilateral• Secondary to chronic keratitis
• Discrete superficial stromal opacities and nodules• Base of nodule may be surrounded by iron deposits
Treatment - similar to spheroid degeneration