Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

Fig. 8.2 Frameshift Mutation As a Result of Base AdditionSlide number 1

A—

Translation Translation—G

—C

—C G—

—A

—T

—G C—

—C

—A

—A U—

—T

—T

—T

—C

mRNADNAWild type

Aminoacid

Directionof

transcriptionand

translation5'

3'

—G

—C

—C

—A

—T

—G

—C

—C

—A

—A U—

—T

—T

—T

mRNADNAMutant

Aminoacid

5' 3' 5' 3'

3' 5' 3' 5'

Frameshift

G—

C—

U—

G—

U—

A—

A—

A—

G—

Nucleotideadded-C

A—

Arg

Tyr

Val

Lys

Arg

Tyr

Gly

Chaintermination

U—

G—

A—

A—

A—

U—

G—

G—

C—

G—

C—

Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

Fig. 8.2 Frameshift Mutation As a Result of Base AdditionSlide number 2

Translation—G

—C

—C G—

—A

—T A—

—G C—

—C

—A

—A U—

—T

—T

—T

—C

mRNADNA Aminoacid

Directionof

transcriptionand

translation5'

3'

5' 3'

3' 5'

G—

C—

U—

G—

U—

A—

A—

A—

G—

Arg

Tyr

Val

Lys

Wild type

Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

Fig. 8.2 Frameshift Mutation As a Result of Base AdditionSlide number 3

Translation—G

—C

—C G—

—A

—T A—

—G C—

—C

—A

—A U—

—T

—T

—T

—C

mRNADNA Aminoacid

Directionof

transcriptionand

translation5'

3'

—G

—C

—C

—A

—T

—G

—C

—C

—A

—A

—T

—T

—T

DNA

5' 3' 5'

3' 5' 3'

G—

C—

U—

G—

U—

A—

A—

A—

G—

Arg

Tyr

Val

Lys

Frameshift

Wild type Mutant

Nucleotideadded-C

Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

Fig. 8.2 Frameshift Mutation As a Result of Base AdditionSlide number 4

Translation—G

—C

—C G—

—A

—T A—

—G C—

—C

—A

—A U—

—T

—T

—T

—C

mRNADNA Aminoacid

Directionof

transcriptionand

translation5'

3'

—G

—C

—C

—A

—T

—G

—C

—C

—A

—A U—

—T

—T

—T

mRNADNA

5' 3' 5' 3'

3' 5' 3' 5'

G—

C—

U—

G—

U—

A—

A—

A—

G—

A—

Arg

Tyr

Val

Lys

U—

G—

A—

A—

A—

U—

G—

G—

C—

G—

C—

Frameshift

Wild type Mutant

Nucleotideadded-C

Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

Fig. 8.2 Frameshift Mutation As a Result of Base AdditionSlide number 5

Translation Translation—G

—C

—C G—

—A

—T A—

—G C—

—C

—A

—A U—

—T

—T

—T

—C

mRNADNA Aminoacid

Directionof

transcriptionand

translation5'

3'

—G

—C

—C

—A

—T

—G

—C

—C

—A

—A U—

—T

—T

—T

mRNADNA Aminoacid

5' 3' 5' 3'

3' 5' 3' 5'

G—

C—

U—

G—

U—

A—

A—

A—

G—

Nucleotideadded-C

A—

Arg

Tyr

Val

Lys

Arg

Tyr

Gly

Chaintermination

U—

G—

A—

A—

A—

U—

G—

G—

C—

G—

C—

Frameshift

Wild type Mutant