controlli di qualità degli mrna (surveillance systems)
TRANSCRIPT
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Controlli di qualitàdegli mRNA
(surveillance systems)
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AUG UAG
mGppp AAAAAAAAAAAAAAAA
PTC
NMD (Nonsense Mediated Decay)
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Lewin, IL GENE VIII, Zanichelli editore S.p.A. Copyright © 2006
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Non-sense Mediated Decay (NMD): complesso EJC
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Non-sense Mediated Decay (NMD)
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Non-Stop Mediated Decay (NSMD)
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Ruolo del tmRNA
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Ruolo del tmRNA
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Regolazione della traduzione
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Transcriptional control
gene
mRNA
protein
Translational control
•Slow•Lasting•Transcription-dependent
•Rapid•Short-lived•Transcription-independent
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Regolazione della traduzione
•generale
•specifica
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Lewin, IL GENE VIII, Zanichelli editore S.p.A. Copyright © 2006
![Page 14: Controlli di qualità degli mRNA (surveillance systems)](https://reader036.vdocuments.mx/reader036/viewer/2022062701/5542eb58497959361e8c3c6b/html5/thumbnails/14.jpg)
Regolazione generale della traduzione nei proarioti
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Lewin, IL GENE VIII, Zanichelli editore S.p.A. Copyright © 2006
![Page 16: Controlli di qualità degli mRNA (surveillance systems)](https://reader036.vdocuments.mx/reader036/viewer/2022062701/5542eb58497959361e8c3c6b/html5/thumbnails/16.jpg)
Regolazione della traduzione
•generale
•specifica
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Lewin, IL GENE VIII, Zanichelli editore S.p.A. Copyright © 2006
![Page 18: Controlli di qualità degli mRNA (surveillance systems)](https://reader036.vdocuments.mx/reader036/viewer/2022062701/5542eb58497959361e8c3c6b/html5/thumbnails/18.jpg)
Lewin, IL GENE VIII, Zanichelli editore S.p.A. Copyright © 2006
![Page 19: Controlli di qualità degli mRNA (surveillance systems)](https://reader036.vdocuments.mx/reader036/viewer/2022062701/5542eb58497959361e8c3c6b/html5/thumbnails/19.jpg)
Lewin, IL GENE VIII, Zanichelli editore S.p.A. Copyright © 2006
![Page 20: Controlli di qualità degli mRNA (surveillance systems)](https://reader036.vdocuments.mx/reader036/viewer/2022062701/5542eb58497959361e8c3c6b/html5/thumbnails/20.jpg)
Regolazione della traduzione mediata da un sRNA regolatore
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Regolazione autogena mediante riboswitch
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Riboswitch(metabolita)
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Riboswitch(temperatura)
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Lewin, IL GENE VIII, Zanichelli editore S.p.A. Copyright © 2006
![Page 25: Controlli di qualità degli mRNA (surveillance systems)](https://reader036.vdocuments.mx/reader036/viewer/2022062701/5542eb58497959361e8c3c6b/html5/thumbnails/25.jpg)
Regolazione della traduzione autogena nei procarioti
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Lewin, IL GENE VIII, Zanichelli editore S.p.A. Copyright © 2006
![Page 27: Controlli di qualità degli mRNA (surveillance systems)](https://reader036.vdocuments.mx/reader036/viewer/2022062701/5542eb58497959361e8c3c6b/html5/thumbnails/27.jpg)
Lewin, IL GENE VIII, Zanichelli editore S.p.A. Copyright © 2006
![Page 28: Controlli di qualità degli mRNA (surveillance systems)](https://reader036.vdocuments.mx/reader036/viewer/2022062701/5542eb58497959361e8c3c6b/html5/thumbnails/28.jpg)
Lewin, IL GENE VIII, Zanichelli editore S.p.A. Copyright © 2006
![Page 29: Controlli di qualità degli mRNA (surveillance systems)](https://reader036.vdocuments.mx/reader036/viewer/2022062701/5542eb58497959361e8c3c6b/html5/thumbnails/29.jpg)
Regolazione della
traduzione delle r-proteine nei procarioti
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Lewin, IL GENE VIII, Zanichelli editore S.p.A. Copyright © 2006
![Page 31: Controlli di qualità degli mRNA (surveillance systems)](https://reader036.vdocuments.mx/reader036/viewer/2022062701/5542eb58497959361e8c3c6b/html5/thumbnails/31.jpg)
Lewin, IL GENE VIII, Zanichelli editore S.p.A. Copyright © 2006